Document e7Jn0Qgyb71E4vEqQmXD6Zq8g

ETH YL C O R PO R A T IO N Ma n u f a c t u r in g De p a h t m e n t J u ly TT, T968 ' PL EASE AOORESS REPLY T O : - BOX 3At BATON ROUGE. LA. 7 0 S2 t Robert A . Kehoe, M .D ., Professor Emeritus o f O ccupational University of Cincinnati Eden and Bethesda Avenues C in c in n a ti, O hio 452T9 M edicine Dear D r. Kehoe: D r. Bock has asked me to furnish you w ith the inform ation requested in your le tte r of June 21, T968. In reference to the case of the gasoline "s n iffe r" re ce n tly reported in the J . A . /V i. A . , the most appropriate source o f inform ation would seem to be the a n a ly ti cal values reported for men who have been placed on lead re s tric tio n . A lis t covering the blood (and simultaneously - obtained urin) values for all individuals a t the Baton Rouge p lant who have been restricted a t any tim e from T944 u n til the present date is enclosed. Values for specimens obtained during the 3 -4 months prior to restriction and after restoral are included in this lis t. There are a few scattered lead values in this lis t that are w ith in the range reported for the patient in the J . A . M . A . a rtic le , but none o f the restricted workers have shown persistently elevated blood lead values comparable to those reported for the gasoline "s n iffe r". In reference to the possible relationship between the concentration o f lead in the urine and that in the blood, the above lis t furnishes some d a ta . A listin g o f a ll determinations on coupled blood and urine specimens recorded for my long-term group o f workmen is also enclosed. A third source o f inform ation w hich m ight have some bearing on this point consists o f the Q u a rte rly Reports: A copy of the pertinent portion o f each Report from T944 through the firs t quarter o f this year is enclosed. M uch of this inform ation is grouped, o f course. The in d ivid u a l values from w hich the Q u a rte rly Reports were com piled cannot be recovered from the records kept in the M edical departm ent. A ll three lists overlap to a greater or lesser extent, o f . course. ' As a q u ic k , rough check o f a possible constant relationship between the concentration of lead in the urine and in the blood, I have plotted the distribution of the "ratios" obtained by dividing the milligrams of lead per lite r of urine by the m illigram s of lead per TOO grams o f (a simultaneously obtained sample of) blood for Robert A . Kehoe, M .D ., J u ly TT, T968 Page 2__________________ those groups in w hich in d ivid u a l values are shown. The distributions so obtained are diown in the graphs attached to the back of the lis t of each such group, I recog nize that a true ratio would necessitate conversion o f values to a common denominator, but the re la tive relationships should not be in great error from the omission of this additional step. Considering the vagaries o f relationships in time o f sampling to portion of work day and work week, the range/exposure conditions involved, and the problems inherent in the random sampling o f u rin e , I was surprised that the values obtained by the above evalua tion were as closely grouped as they proved to b e . It was also interesting that, in my long-term study group, the results were sim ilar for "pure" organic lead exposures and for "m ixed" organ ic-in org anic lead (furnaces, m elt pot, a llo y) exposures. A very hurried rough calculation of weighted values for the an a lytica l results shown in the Q u a rte rly Reports indicates the mean " r a tio " (as previously defined) is about 2 .2 ; this is q u ite close to the means of the other groups. I la ck the tim e to attem pt a more d e fin itiv e analysis o f these data, but, to me, further study would appear to be in d ic a te d . U n fo rtu n a te ly, I have no p ra ctica l experience in matters o f this nature to guide my judgm ent. I shall be most interested to hear whether or not you consider further evalua tion along these lines to be warranted and to learn the results o f any such study that you m ight undertake. If I can provide further inform ation or assistance, please le t me know . Sincerely, TRR/hc A ttach. Theodore R. Robinson, M . D . , I . M . D . 0004963 ^ w X S I Z F 'HESIffifrERMINATIONS o f l e a d i n c o u pl e d 13 - n o\o URINE AND BLOOD SAMPLES OCT 22 TEL Operators with 20 or more years o f continuous service-- working in furnaces, a llo y or melt pot a t time samples taken. Records from 1955 through 1967. Forty in d iv id u a ls. One hundred ^ovu^een pairs o f urine-^lood deter^iipgtions. Uu Badge # 120 155 69 27 448 29 260 178 189 251 261 498 490 239 293 457 ; 24 217 206 Date Urine, m g./l. Blood. mg./lOO gm Ratio 4/28/60 3/24/58 3/12/58 6/11/59 3/18/65 11/7/57 3/4/59 4/6/61 9/18/67 1/5/56 4/23/57 11/ 2/ 60 3/9/61 5/9/62 6/13/62 9/11/63 2/2/54 . 9/9/63 10/29/64 10/7/57 9/8/55 4/29/60 9/23/64 7/3/57 2/6/58 4/14/59 7/24/62 10/20/64` 12/4/58 6/9/66 11/20/58 4/7/60 8/22/61 11/2/61 9/9/63 12/8/64 6/4/62 9/17/62 9/18/64 3/2/66 10/22/65 9/12/60 9/11/63 12/14/64 10/20/65 --/o .o s i- \^>57 wi045 . - V02" ^121 V>P8T' ~^06? V044n. ^<093 v^082' ^sj374 \ju033 V052- .148 \*l5 \iP97 - -85 -045 K. 082 .188, ,024s.242 .089.150 .113 s .257^ .113- . x . 090%.- 097\ .082.041^ ; .079 ' . .077'- .070 . . .081 x ,154>. \ .083 ^ .190n^ : v^030 / ^ K7025 ^015 ^<0 13.. ^<033 v^047 - n^ 7 w 0 3 1 -' v J349 \J563 vW n s jQ46-^ \J334^ V036 "v04lv/031 -- 037 v>924 v^25 ^P37 ->^128' .024> .0 3 8 .034. .056 .060.058' .032vO50' -037 .027; ,028u .028. .026' .035 .030 .039 ' *033 , - .038'. v . 033^ V .049c^ / 2.7 2.3 3.0 3.5 2.3 2.0 3.8 0.8 0.4 2.5 2.0 1.1 1.8 1.0 3.1 2.4 2.7 0.9 1.3 4.8 2.8 4.0 4.3 5.0 5.2 3.4 4.9 . 0.7 4.3 1*5 2.6 3.5 5.1 3.0 3.3 3.5 2.9 1.6 2.3 2.6 1.8 2.5 4.0 2.5 3.9 Comments . . . ' KF 0004364 N 7204.01 9 1 Atte # Date 72 1/18/58 2 /1 7 /5 9 3 /1 2 /5 9 3 /2 0 /5 9 10/ 31/61 ` 9/25/63 1 1 /6 /6 4 99 8/19/64 139 6/15/59 6 / 8/60 240 11/ 7/60 2 76 6 /15/59 6 / 8/60 9/18/63 386 12/18/53 5 /2 3 /5 6 -25 10/ 3/61 9 /2 5 /6 3 8 /2 4 /6 5 1 2 /1 /6 5 6 / 8/66 360 7/13/59 6 / 8/61 7/27/61 2 /2 0 /6 3 7 /7 /6 4 416 3/13/61 10/ 11/62 1 /5 /6 5 414 5 4-765 290 4/7/58 8 / 11/61 9/25/62 8 /2 8 /6 3 5/10/67 353 5/19/58 406 4/24/58 4 /2 9 /6 0 9/20/61 10/ 9/61 305 10/23/59 9/20/61 4 /5 /6 2 5/14/62 10/30/67 11/20/67 73 9/19/58 5 /2 4 /6 1 5 / 30/61 8 /1 4 /6 1 7 /2 /6 4 77 8/2/65 8 5/ 31/60 3 /1 /6 1 \u 7/ 11/66 86 3/12/58 1 / 1 3 /6 0 0004965 U rine, m g ./l. 0 .1 2 2 .3 0 8 .319 ' .3 0 0 .0 5 0 .042 .121 .189 .093 .1 0 2 .0 57 .038 . 068. .0 7 0 .117 .101 .232 ill6 .2 1 0 .148 .150 064 . .052 .088 .097 *069 .118 .125 *152 .0 8 3 .097 .121 .174 .1 2 0 .185 .076 .0 5 0 .065 .057 ' .051 .146 .136 .132 .125 . 23^ .283 .104 .166 .1 6 8 .089 .150 .081 .247 .0 7 8 .161 . .034 .086 ' B lo o d , mft./lOO m S' 0.049 .053 . 058' .059.0 3 2 .0 5 0 .063 .0 2 7 .054 .035 .035 .031 ^035 .029 .053 .040 .0 7 6 - .0 4 7 '. .0 3 8 .066 .049- .037.0 8 8 .055 .048 .032 .059 .046 r037 051 .*038 .037 .057 .049 .0 6 1 - .0 3 6 .0 2 0 .047.1 6 0 *045 .054 .046 .048 .050 .069 .085 .052 .017 .046 'COAM . .041 .062 .0 7 6 .054 .054 .040 .056 R atio 2 .5 5 .8 ' 5.5 5 .1 1 .6 0.8 1 .9 7 .0 1 .7 2 .9 1.6 1 .2 1 .9 2 .4 2 .2 2 .5 3 .0 2 .5 5 .5 2.2 3 .1 1 .7 0 .6 1 .6 2 .0 2.2 2 .0 2 .7 4.1 1 .6 2 .6 3 .3 3 .0 2 .4 3 .0 2 .1 2 .5 1 .4 0 .4 1.1 2 .7 '3.0 2.8 2 .5 3 .4 3 .3 2 .0 9 .8 3 .6 1 .7 3 .6 1 .3 3 .2 1 .4 3 .0 0 .8 1 .5 Comments ' # 94 219 282 % - 3- Date 5 /1 5 /5 7 1 1 /2 5 /5 7 8 / 22/58 6 /1 /5 9 9 /2 0 /6 1 1 1 /3 /6 1 9 /3 /6 4 2 /1 /6 5 10/14/65 8 /2 4 /6 1 1 1 /2 0 /6 4 U rine, m R ./l. ' 0.120' .125- .148 .1 1 8 / .059 .1 1 8 .189 .073 .103 .096 .045 B lo o d , msc./lOO gm. 0.046 .045 .054 .0 5 0 .054 .042 .053 - .046 ' .049 .025 .036 .. R atio 2 .6 2 .8 2 .7 2 .4 1.1 2.8 3 .6 1.6 2.1 3 .8 1.2 Comments K 0004968 X. RUINATIONS OF LEAD IN COUPLED URINE AND BLOOD SAMFLES 'C C -rl ~X'U s'p rvr-^y. TEL O perators wMith' mZOAr more y e a r s o f co n tin u o u s s e r v i c e -- n o t w orking i n fu r n a c e s , a llo y or m elt pot a t tim e sam ples taken ( i . e . , exposure presumably p rim arily to organic le a d .compounds. R ecords from 1955 th rou gh 1 9 6 7 . S i x t y - s i x i n d i v i d u a l s . One hundred th ir ty -n in e p a irs o f u rin e-b lood determ inations. - . Badge # D ate U r in e , m g . / l . ;-. i: B lo o d , m g ./l0 0 gm..-Sa: 286 1/7/66 . 0.074 * 333 4 /1 2 /6 7 142 401 1/12/66 126 164 3/9/61 ~*033 3 /1 4 /6 1 W Z34 3 /1 6 /6 1 ^065 3 /2 0 /6 1 ^ .061- 3/ 22/61 4 /6 /6 1 \_*O l6' ^054- 5 /2 4 /6 1 W045' 6 /1 0 /6 6 ^ .151\ 51 9/2 8 /6 1 V .028 46 9 /2 0 /6 1 \^~. 046" 2 /2 0 /6 4 A ^.136 1 /7 /6 5 ^ .091 159 8 /1 9 /6 4 V .127 28 1 /1 1 /6 7 ^X042 157 9 /2 0 /6 1 V `101 3 10/23/64 .102 7 /2 0 /6 6 ^ .118 2 /2 0 /6 7 ^ -.090 1 2 /1 9 /6 7 v"i201 63 1 / 31/66 v/.'052 509 10/20/64 u .1 6 4 1 /2 0 /6 7 w .1 4 5 215 10/17/61 ^ ..0 7 8 6 /4 /6 4 11/12/65 u -1 7 5 v ,.186 7 /1 1 /6 6 v^.182 148 9 /1 3 /6 1 ^r074 243 - 6 /1 /6 0 ^ .-0 5 0 1 0 /1 6 /6 2 ^ .261 1 0 /2 4 /6 2 v^.097 1 0 /2 9 /6 4 V' 98 334 4 /2 8 /6 5 %-<122 185 7/30/62 \ .113 2 /5 /6 4 v .1 8 5 1 0 /1 /6 4 w .084 202 9 /1 9 /6 1 ^ i088 443 1 2 /2 9 /5 8 V-035 5 /2 7 /5 9 J -.0 7 7 10/23/61 W .095 4 1 0 /1 1 /6 1 VA 062 278 10/18/61 .084 ^ O.3 O ^ , 034' ' ,, .043 ^ 35 U-'P39 w 025 WO3O V ip30 ^029 v__ .0 2 8 w . 042 'vA . 029 V -O 38 V i 042 W .025 -.0 2 7 \^ o z 5 W -.043 v - .037 '-- . 0 5 4 ' v^ .0 5 8 A* 056 ^<031. w .042 U - . 0 3 2 '. w.036 w .0 4 2 v .045v^047>. w 037 v .044' V-. ,066-i '-- . 0 1 6 w .045 .026 N .054^ ^ .0 3 9 W .051 v^-,047 V...041 v^ .037 w 039 ^ .0 4 2 \ A .034 2 .5 4 .2 2 .9 0 .9 6 .0 2 .6 2 .0 0 .5 1 .9 1 .6 3 .6 . 1 .0 1 .2 3 .2 3 .6 4 .7 1 .7 2 .3 2 .8 2 .2 1 .6 3 .6 1 .7 3 .9 4 .5 31.2 4 .2 4 .1 3 .9 2 .0 1 .1 4 .0 6 .1 2 .2 4 .7 " 2.1 4 .7 1 .6 1 .9 0 .8 2 .1 2 .4 1 .5 2 .5 Acute exposure. Acute exposure. KE K 0004969 Badge # Date 47 10/9/61 311 6 /8 /6 0 41 10/9/61 355 5/27/59 1 0 /2 /6 1 429 10/28/61 3 /2 /6 6 9 /2 5 /6 7 56 10/18/61 67 9/21/61 109 9/22/61 420 5/27/59 8 /2 5 /6 1 1 0 /4 /6 1 1 /2 3 /6 ? 20 10/17/61 10/23/64 138 10/16/61 174 9/ 16/66 10/26/66 304 12/ 16/60 8/21/63 8/16/66 366 9/29/61 10/10/61 1/11/62 371 10/30/61 1 0 /1 2 /6 4 146 5/28/59 385 5/31/60 7 /2 5 /6 1 9 /2 1 /6 1 7/30/62 9 /1 7 /6 4 5 /2 /6 6 256 . 10/3/61 393 8/25/61 9/11/61 1 0 /3 /6 1 1 0 /8 /6 5 396 9/18/61 332 9/21/61 2 /2 6 /6 4 * 10/1/64 8 /2 2 /6 7 216 9/12/61 254 12/22/65 1 /1 1 /6 6 389 10/9/61 405 10/18/61 10/14/64 10/11/65 280 9/29/61 452 9/28/61 U rine, m g ./l. ^ 0.038 .014 - .096 . .106 . .090 v .101 v .086 >>137 v .090 , .132 . .118 ..0 3 9 _ \ 8 6 . .060 .'.0 9 1 L..-132 w .195 U-.095: ,-.0 7 0 v^ i24 V,r.ll6 \, 9 5 v. .1 5 0 >093 v. .112 U -055 ^ ,117 vxC-58 -.033 V- .3 2 6 v^ .1 7 0 x .141 ^ .194 `^ 0 7 7 v_.084 >>074 u ^102 o-159 \JJ06 ^68 \ . 065 ,.126 ,1 6 3 - . ,"1 1 & " >H 9 ..076^ ' W 226; C..I2 3 >017 >100 ` .056 ^ B lo o d , mg.,/ i o n gm. > 0.029 0 .018 . .096 , . .032 \ .034 v.'*35 x .036 v .047.v .0 3 0 > .0 5 7 , .040 u-.037 ^ .113 -.0 9 7 ,.0 4 7 0 O6I . .042 >040 '.,0 9 4 o052 v .0 5 3 t.0 4 9 > .052 -- .078 .041 ^ .046 > .0 4 6 w 037 - .039 ' -.057 ^ .0 6 3 o 062 _040 >042 : .027 . * >026 W 092 >049 >037 .040 .034 ^035 W 041 l .0 4 0 vJ329 ^062 66' o& o- * p 27 u.030 0336- R a tio Comments 1 .3 0 .8 1 .0 3 .3 2 .6 2 .9 2 .4 2 .9 3 .0 2 .3 3 .0 1 .0 0 .8 0 .6 1 .9 2 .2 4 .6 2 .4 0 .7 2 .4 2 .2 1 .9 2 .9 1 .2 2 .7 1 .2 Acute exposure 2 .5 1 .6 0 .8 5 .7 Acute exposure 2 .7 `2 .3 4 .8 1 .8 3.1 i. s 3 .9 1 .7 2 .2 4 .5 1 .6 3 .7 4 .6 4 .0 3 .0 4 .1 2 .8 . 3 .4 3 .1 5 .1 2 .4 3 .3 . 1 .6 Badge # Date U rine, m g ./l. 460 ' 6/4/59 10/18/61 1 1 /5 /6 2 199 7/19/60 r 9 /2 / 6 0 43 8/25/61 10/30/61 462 10/9/61 9/19/61 277 10/2/61 848 9/19/61 1 0 /9 /6 1 3 /1 7 /6 4 375 9/17/64 1 1 /6 /6 4 5 /1 9 /6 5 430 8/23/61 1 0 /2 /6 1 9 /2 5 /6 2 8 /1 9 /6 4 106 4/26/60 8/15/66 6 10/17/61 33 8/25/61 1 1 /1 /6 1 108 7 / 22/60 149 9/12/61 226 10/18/61 230 9/20/61 284 2/22/61 9 /2 0 /6 1 1 1 /6 /6 1 1 1 /1 9 /6 4 1 /2 7 /6 7 2 /3 /6 7 258 10/ 26/66 346 9/28/61 1 2 /1 6 /6 4 5 /2 4 /6 6 226(con td )l2/l6/65 1 /3 /6 6 U .057 v -< * 7 ^064 UO83 V073 V/.113* u089> V'-026 v ' 057 V.1 5 0 .088- 1-147 v^ l50 u ^ l4 4 w l2 7 v * l62 v~L-24 V.127 \^ 1 2 7 :.l-24 U140 ^165 -rl20 C 078 .1 0 3 142- U33 \yU80 -.073\.1 1 9 ,0 6 4 .112 .094 .098 .172 *004" .117" \sJ.42^3 .'2 0 J *090 . ' B lo o d , mg./lOO gm. L-032 U.-.042-. V .03I v068 . u.0 5 9 < v^.040 L-.051 V .097 '...,.038 .1 6 ^ W 036 > ,,.0 2 4 Us-060 >*047 .035 u,.039 1.034. ' W052- v.0 3 0 *.037 . .037 v-< 043 , - . 0 57 - 044 .040 .061- ..039 ..038 ,, - . 043 `.0 3 6 ' .035 \ . 029 '.045 vG49 .039 .0 4 7 - V029 - .063 >058 .046 R atio 1 .8 1 .1 2 .1 1 .2 i/r 1 .9 2.2 0.5 0 .6 3 .9 0 .5 3.1 6.1 2 .5 3.1 3 .6 4 .2 3 .6 2 .4 4.2 3A 3.& 3 .8 2 .1 1 .8 2 .6 2 .3 3 .4 2 .1 1 .7 3 .3 1 .8 3 .9 2 .1 2 .0 4 .4 1 .8 4 .0 2 .2 3 .5 2 .0 Comments K 0004970