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September 24, 2001
Karen Lannon U.S. EPA, OPPTS Document Control Center 401M Street, S.W. (TS-7407) Washington, DC 20460
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Reference: AR266
Dear Ms. Lannon:
I have once again prepared authentic sanitized copies of the two presentations we gave on February 21,2001. A paper copy of each presentation is enclosed for the public record.
These presentations are as follows:
"DuPont Research Program Update and Status Report" - February 21, 2001
and
`Telomer Research Program Update and Status Report" - February 21, 2001.
Each of these reports has been company sanitized. They do not contain TSCA CBI. Each and every chart that has had CBI removed has been marked with the following note: "CBI Information has been redacted."
Please let me know if you have any additional questions on these two documents. You
can reach me via phone on (302)992-3672 or fax on (302)892-1135. My email address is
stephen.h.korzeniowski@usa.dupont.com.
^
With regards,
SHK/klo
Attachment
Stephen H. Korzeniowski Market & Business Manager v?
Company Sanitized
21 Feb. 2001
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Company sanitiz,
Presented to U.S. EPA, OPPT 21 February, 2001
(BUSH Chemical Solutions Enterprise
"Company Sanitized. Does Not Contain TSCA CBI."
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Agenda
Overview Toxicology & Descriptive Biology Environmental Fate Environmental Effects Summary & Path Forward
Chemical Solutions Enterprise
"Company Sanitized. Does Not Contain TSCA CBI."
DuPont Effort Overview
21 Feb. 2001
rCeBdaIcItnefdormation has been
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DInutPeromntedFilautoerso, tSeulormfaecrtaPnrtso,dPuocltyGmreorusps:
1) Intermediates
CF2=CF2 (TFE)
Sales Products
21 Feb. 2001
F(CF2CF2)nI (Telomer A)
n = 2-8
T
F(CF2CF2)nCH2CH2I (Telomer B)
2) Su rfAancitoannicts- P/h"oMspohaletec. uClaerbso"xylate, Sulfonate
Nonionic - Ethoxvlate Betaine
F(CF2CF2)nCH2CH2OH (Telomer BA)
Straight Chain Alkyl
F(CF2CF2)nCH2CH20C(0)C(R)=CH2
3) Po lAyEmsctreyerlrics
Amide
Urethane Urea
Zonyl TM (r=ch3) ; Zonyl TAN (r=h)
m m Chemical Solutions Enterprise
"Company Sanitized. Does Not Contain
rTSCA CBI."
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Toxicity Database :
High Production Volume Chemicals
Acute Toxicity Oral, Inhalation Eye, Skin Irritation Skin Sensitization
Repeat Dose Toxicity Oral, Dermal Inhalation (AEL)
Genetic Toxicity
Developmental Toxicity
Reproductive Toxicity
Eco-toxicity Aquatic Toxicity
Environmental Fate & Effects
UR.eSq.uIeTsCts#45,46
21 Feb. 2001
ChemicalSolutions Enterprise
"Company Sanitized. Does Not Contain TSCA CBI."
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TOXICITY DATABASE - DuPont Fluorotelomers
21 Feb. 2001
Acute Toxicity Oral Dermal Absorption Inhalation Irritation - Eye Irritation - Skin Skin Sensitization
Intermediates Surfactants Polymers
CBI Information has been redacted
Repeated Dose Toxicity Oral Dermal Inhalation
m m ChemicalSolutions Enterprise
"Company Sanitized. Does Not Contain TSCA CBI."
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TOXICITY DATABASE - DuPont Fluorotelomers
21 Feb. 2001
Intermediates Surfactants Polymers
Genotoxicity Gene Mutation Ames Others
Chromosome Aberration In Vitro (CHO) In Vivo
rCeBdaIcItnefdormation has been
Developmental Toxicitv Rodent Non-Rodent
Reproductive Toxicitv Structural Evaluation Functional Evaluation
Chemical Solutions Enterprise
"Company Sanitized. Does Not Contain TSCA CBI."
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TOXICITY DATABASE - DuPont Fluorotelomers
Intermediates Surfactants Polymers
Ecotoxicity Aquatic Tox. Fish Daphnia Algae
Environmental Fate Log Kow Biodegradation Accumulation Persistence
rCeBdaIcItnefdormation has been
Chemical Solutions Enterprise
"Company Sanitized. Does Not Contain TSCA CBI."
DuPont Toxicology Studies Timeline rCeBdaIcItnefdormation has been
21 Feb. 2001
COPQjii ChemicalSolutions Enterprise
"Company Sanitized. Does Not Contain TSCA CBI."
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Toxicology Studies : ZonylXXX
21 Feb. 2001
Repeated Dose Toxicity:
Genetic Toxicity:
Developmental Toxicity: CB, Infomlation has been
Reproductive Toxicity:
redacted
Biopersistence: 10 day oral rat
Environmental Toxicity:
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"Company Sanitized. Does Not Contain TSCA CBI."
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Zonyl XXX Studies : Update
90 Day Oral Gavage, One-Generation Reproduction
CBI Information has been redacted
Chemical Solutions Enterprise
"Company Sanitized. Does Not Contain TSCA CBI."
Zonyl XXX Studies : Update
Present Findings 90-day
Reproduction
rCeBdaIcItnefdormation has been
21 Feb. 2001
Chemical Solutions Enterprise
"Company Sanitized. Does Not Contain TSCA CBI."
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Zonyl XXX Studies : Update
Developmental Toxicity
Genetic Toxicity: Aquatic Bioconcentration Screen:
CBI Information has been redacted
Chemical Solutions Enterprise
"Company Sanitized. Does Not Contain TSCA CBI."
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21 Feb. 2001
DuPont Toxicology Studies : Timeline
CBI Information has been redacted
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ZonyPXX Kinetics
CBI Information has been redacted
Chemical Solutions Enterprise
"Company Sanitized. Does Not Contain TSCA CBI."
Ki^netAics
21 Feb. 2001
CBI Information has been redacted
Chemical Solutions Enterprise
Company Sanitized. Does Not Contain TSCA CBI."
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Radiolabeled Telomers
F(CF2)8-CH2CH2-X
Neededfor Pharmacokinetics & Environmental Fate Studies
CBI Information has been redacted
21 Feb. 2001
<m m Chemical Solutions Enterprise
Company Sanitized. Does Not Contain TSCA CBI."
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Radiolabeled : Synthesis Route "A"
21 Feb. 2001
CBI Information has been redacted
(ffllEjSii Chemical Solutions Enterprise
Company Sanitized. Does Not Contain TSCA CBI."
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Environmental Compartments based on emissions assessment
21 Feb. 2001
rCeBdaIcItnefdormation has been
Chemical Solutions Enterprise
"Company Sanitized. Does Not Contain TSCA CBI."
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21 Feb. 2001
Environmental Fate & Effects Work Plan
r
Physical Properties
UV/Visible Spectrum Water Solubility Adsorption to Glass Air-Water Partition
Coefficient
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Environmental Fate : Abiotic
Hydrolysis Adsorption / Desorption Indirect Photolysis in Air
Environmental F a te : Biotic
Anaerobic Biodegradation* Aerobic Biodegradation*
(* Radiolabeled Material)
bCeBeInIrnefdoarcmteadtion has
Chemical Solutions Enterprise
Environmental Effects
Bioconcentration Factor 90 Day Early Life Stage Study -
Rainbow Trout ^ *21 Day Invertebrate Daphnia Study
"Company Sanitized. Does Not Contain TSCA CBI."
Xi
21 Feb. 2001
DuPont Environmental Fate & Effects Studies
Focus o n :
- Acute Aquatic Toxicity (Daphnia, Algae, Fish) - Adsorption / Desorption - Biodegradation - Chronic Aquatic Toxicity (Daphnia, Trout) - Bioconcentration Screening
CBI Information has been redacted
i Chemical Solutions Enterprise
"Company Sanitized. Does Not Contain TSCA CBI."
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Zonyf TEL-X
F(CF,CF2)nCH2CH,X n=3-6
21 Feb. 2001
CBI Information has been redacted
i Chemical Solutions Enterprise
"Company Sanitized. Does Not Contain TSCA CBI."
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21 Feb. 2001
DuPont Environmental Fate & Effects Timeline
CBI Information has been redacted
H K >. Chemical Solutions Enterprise
"Company Sanitized. Does Not Contain TSCA CBI."
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BCF Screening Protocol
Objective: To compare the uptake and depuration in fathead minnow for a
series of fluorotelomer intermediate, surfactant and polymeric products.
Method: uptake (14 days continuous exposure) and depuration (14 days) phases analytical confirmation of test concentrations and tissue residues analysis by total organic fluorine on a dose-normalized basis
Results: Whole fish bioconcentration factors for the series of test materials
<0LLEI!tQi ChemicalSolutions Enterprise
"Company Sanitized. Does Not Contain TSCA CBI."
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DuPont Path Forward Items
Toxicology & Descriptive Biology Environmental Fate Environmental Effects Summary & Path Forward
21 Feb. 2001
l Chemical Solutions Enterprise
"Company Sanitized. Does Not Contain TSCA CBI."
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