Document e5ybrXMjZMrpD4daY3wKBnM3g

August 21: 2000 Document Processing Center (`7407) Office of Pollution, Prevention and Toxics U.S. Environmental Protection Agency 401 M Street! S.W. \,/Vash:ngton, DC 20460 Attenilon: Section 8(e) Coordinator Re: TSCA Section 8(e) Supplemental Submissions: Docket Nos. 8EHQ-1'180-373 and 8EHQ-1180-374 Dear Sir/Madam: .+a." 3M Company ("3M") requests that EPA redesignate: to the TSCA Section 8(e) docket, thirty studies which 3M previously submitted to EPA and are presentiy contained in "For Your Information" (FYI) docket number 1378. These studies and information supplement 3M's previous 8(e) submissions in Docket Numbers BEHQ1180-373 and SEHQ-1180-374. Attachment One lists the studies for which 3M requests redesianation. We have endeavored to include sufficient identifying information to faciiit.ate:he redesignation! including date of study submission; study title: study date; studv type; and chemical. These studies consist of health and environmental effects data, environmental fate information: and human and environmental exposure data on various fluorochemicals; these data are consistent with information already inciucied in the TSCA Section 8(e) docket for these or related compounds, but 3M has concluded these date may not be, strictly speaking, "corroborative" of previously reported or published information as defined in EPA's reporting guidance. 3M appreciates EPA's attention to this matter. Please do not hesitate to contact the undersi,gned if you have any questions or require further information regarding this sub&&ion.. Very truly yours &.JAwq Q. I&.& iq.34 Dr. Katherine E. Re.ed, Ph.D Executive Director 3M Environmental Technology And Safety Services Submission Date C. 04/21/2000 Ch emicaV Product Name St&v Title K PFOS Orel (Stomach Tube) Developmental Toxicity Study of PFOS in Rabbits Laboratq} Argus Research fiL/aqbo"r"a&torqies, ingc.9 u4/21:2ooc) -- K PFOS; T-6246: K-95 PFOS: PFi-S: PFOA NEtFOSAA; FOSA; N-MeFOSEP\; PFOSAA M570; M556 Single Dose Intravenous Pharamacokinetic Study of T6246 in Rabbits. 3M Environmental Laboratory Study #AMDT-042095.1 3M Technical &..& `- cq yg Fluorochemical Exposure Assessmen: of Decatur Chemical and Film Plant Empioyees Medical Department. 3M Company up&- Q "pn Study No. 418-012 AJvlDT- 042095.1 EP1-0006 Srudy Date Study Type 01/11/1999 Health Effects: Developmental Toxicity 1 l/11/1995 Health Effects: -Pharmacokinetic & Metabolism Studies 08/I l/l 999 Human Data & incidents: Medical Surveys, Clinical Studies, Reports or Allegations of Worker or Consumer Effects 35/04i2000 DEA PFOS; FC-99 New iomwle: T- 2509CoC Two Week Oral Rangefinding Toxicity Study aiT-2509 CoC in Rats Riker Laboratories, Inc. 4-8 2,`$.. qJ-7 179RRO23 ,' 02/2511980 Health Effects: Acute Toxicity 05/04/2000 c5J0412000 0510412000 C904R000 -- ~~05/04/2009 K PFOS K PFOS K Pf OS: T-6295 K PFOS; T-6295 K PFOS; T-6295; Telomer Alcohol: Telomer Actylate; PFB8 PFHS Acute Oral Toxicity (LD50) Study in Rats PFOS: A Dietary LC50 Study with the Northern Bobwhite 104 Week Dietary Chronic Toxicity and Carcinogenicity Study with PFOS Fotassium Salt in Rats International Research and Development Corporation i 37-083 /fA &$. 04x3 Wildlife International &&Z?Q-(3 ?X.> 454-103 .Covance __Laboratories. Al;: `2 20 I- Inc. e? $S 6 632%i63 26 Week Cepsule Toxicity Covance Study with PFOS: T-6295 in Laboratories, Inc. Cynomolgus Mcnkays (Volume I and Ii) /q.!Q 2 2 & r-p 6 &?L 6329-223 8 $xploratory 28Day Oral Toxicity Study with Telomer Alcohol, Telomer Acrylate, PFBS. PFHS, and PFOS (positive control) 3y Daily Gavage In The Rat Followed by a 14128 D2y Recovery Period 3M Environmental Laboratory (FACT) p71,tq 2 2&... 7.H FACT-TOX- 120.3 05/31/1978 Health Effects: Acute Toxicity 04/26/2000 Environmental Fate & Toxicity Data: Avien & Other Wildlife Health Effects: Carcinogenic&y ,..`Studies . 04/i2/2000 Health Effects: Chemical-Tissue Observations 0611111999 Health Effects: Subchronic Toxicity 05/C4/2000 Peffluoroethylcyclo hexyl sulfonate DEA Salt; FC-90: T-2960 CoC Acute Ocular Irritation Test with T-2960 CoC in Albino Rabbits Safety Evaluation Laboratories, Riker Labora!ias, Inc. 0880EB0598 02/18/1981 Health Effects: DermaWEye Irritation Pugeliof3 , ' J ). El'44 Submksion Dgare ChemicaU Product Name Stu@ Title Laboratory stufiy Stu@ No. Date 05/0412500 051042000 05!04/2cf00 PFOS Fluorochemical (FC) Levels in KaYve Rats - Further Investigation of Rat Chow 3M fi/q2.2& 2,. ' y&3 TiiBl6.9; DT21 PFOS. PFCS; PFHS: PFDS: PFOA PFOSAA: M566; M670; M463: M6:3 Fluorochemical (FC) Levels in Na'ive Rats, T-6316.9 ffjq 2 z&+3 Analysis of FCs ,in Sempies of Children's Sera j& 2 `z&.- q1;1 3M Medkzl Department, Toxicology Services 3M Envimnmentai Technology & Services T-6316.9 FACT-GEN011 Fotassium pemuoroethylcycto hexyl sulfonate: G-96; T-2308 CoC Acute inhalation Toxicity Stuoy of T-2308 CCC in ttte Rat Bioidynamics. Inc. 75-7187 05/14/l 9QQ Environmental Fate 6 Toxicity Data: Other Environmenta! Information 05/14/l 999 Health Effects: Pharmacokinetic 8 Nietaboiism Studies 05/21/l 999 Human Data & Incidents: Medical Surveys, Clinica! Studies, Reports or Allegations of Worker or Consumer Effects 04/:2/1979 Health Effects: Acute Toxicity 05/?8/2000 5\ OW 6123X 05/l 8/2000 ow 0:2000 ., PFOS; FOSA: PFOA: PFHS Quantitative Analysis of FCs in Environmental Samples /j.<#? 2-z.& /%-+I& 2-. 3M Environmental Laboratory (FACT) FACT Get-021 ( Gen024, GenO30, Gen033 FOSA: T-3421 Acute Oral Toxicity Screen with T-342; in Albino Rats Riker Laboratories, 0883ARO287 N-WOSA N-EtFOSA A Developmental Toxicity Study of 37 3401 in Rats Primary Eye irritation WIL Research Laboratories, Inc. . `. Product Safety Labs 157016 387'1 N-EtF0S.A; N- EtFOSE Alcohol; N-MeFOSE Alcohol Eicaccumuietion of FC in Tennessee River Fish 3M Environmental 76-2740 Laboratory dig 2 2 6 ._ cy y +./ 06/10/2000 Environmental Fate & Toxicity Data: General OlMi/1984 Health Effects: Acute 05/30/l 997 Health Effects: Deveiopmental Toxicity 11to31 995 `Health Effects: DennaVEye Irritation 05/22/l 979 Environmental Fate ~~~~ZZZ%Pers~ 05!18:2003 -G5ilEY2000 05/l 6i2000 Puge 2 of3 N-EtFCSE AJc~hol +bsorption and -8iotrancformation cf N-ethyl FOSE and Tissue Distribution and Elimination of Carbon 14 after Administration of N-ethyl FOSEt 4C in Feed Riker Laboratories, Inc. ./I) R 2.2 I&- 0 ?d 5 N-EtFOSE AIcohol Oral (Gavage) Developmental Toxicity Study of NEtFOSE in Rats A/f 2a&.- iq El TTE; N-E!FOSE Alcohol Ora! (Stomach Tube) Developmental Toxicity Study of N-EtFOSE in Rabbits Argus Research Laboratories, Inc. /L'1r.f 2 a 6 .* 0 (7 & y- ~18-010; 6316.8 PQ 01/29/1983 Health Effects: Pharmacokinetic & Metabolism Studies 121?711998 Health Effects: Developmental Toxicity 01/11~1999 Health Effects: Developmental Toxicity -I___ EP.4 Submission Daze ChemicaV Product Name Study Title Laboratory StucQ No. StUdJ) Date Stuify Type 05116l2000 N-EffOSE Alcohol: FM-3422 @5!i Sl2OGG N-W OSE Alcohol; T-5674 Evaluation of the Bioconcentration Potential of FM 3422 3M Environmental Lsboratoly (FACT) &k22 &-fj qyo 9970612623 Determination of the NOTOX _ 12i275 Partition Coefficient (n- octanoliwarer) of T-5874 by high performance liquid chromatography (.HPLC) . . 0811611978 04/07/1994 ,Environmental Fate 8 Toxicity Data: BioaccumulationlPersi stence Environmental Fate & Toxicity Data: BioaccumulationlPersi stence N-ElFOSEA N-EtFOSEA: T- 6322 Determinstion of PhysicoChemical Properties of ~~~D;l&we. 0 7 :f-j Twenty-eight-&y Repeated DOSE Oral Toxicity Sfudy of Sample D-T in Rats, T-6322 Mitsubishi Chemikd Safety institute, Ltd. Bio-Medical Research Laboratories 48223.48227 02/14/1996 BMR lil3C 02%`1993 j$l;`.az &-. t?:$ c .y Environmental Fate & Toxicity Dats: BioaccumulstiordPersi stence Hearth -Effects: Subchronic Toxicity 0511E.'2000 V-MeFOSE Alcohol: FM-3925 Distrioution Coeficient of FM3926 in N-Octanol Water /qg 22.&T.*. "3:.p 3M Envircnmenta! Laboratcry (FACT) 997001,?6QO, .0. 1/10/1979 ". _I ; Environmental F&e & Toxicity Data: BioaccumulationlPersi stence 05/18!2003 N-MeFOSEA: T- 5869 Determination of the Pollution Coefficient (noctanoliwater) of T-5869.4 by high performance liquid chromatography (HPLC) NOTOX T-5069.4 .; 04/07/l 994 .. .. Environmental Fate & Toxicity Qata: -BioacGmulation/Persi stence , 35l50.`%3OC -- 05i25i2000 05!2512000 PFOSAA T-329:! cot NH4 PFOA; T- 3974; K-126 PFOA emu!sifier, T-6564; FC-1015 ACUtE Orai Toxicity Screer, with T-3290 CoC in Albino . Rabbits Riker ispors:ories, Inc. Ftimary Eye Irritation In Rabbits, T-3974 ' Hazelton Laborstories Primary Eye Irritation/Corrosion Study of T-6564 in Rabbits (OECD Guidelines) Cornins Hszelton inc. 0882ARO362 1,1105/1982 Health Efiects: &Uie Toxicity 61005209 CI-fiN 60504574 .. 01114/1987 . Health Effects: DermaWEye irritation :; `.' 0910511996 Health ,Effects: DermaUEye Irritation . . .