Document e5vYX1NGBxa1BxRNJBa5Okqe

bees D. R. Pogue - LOS ANGELES April 2S, 1968 Hies Elnor Perry, R. M. McCulloch Corporation 6101 West Century Bled. Los Angeles, California 90045 Dear Miss Perry. Mr. Pogue, of our Los Angelea Offioa, has asked ms to forward toxicity and safe handling information relative to our fireresistant hydraulic fluid, Pydraul 312. The oral toxicity of Pydraul 312 shews an LDsn to rats of 6500 mg/kg and it is classified as 'practically non-toxic" fron the acute oral point of view. When applied to the skin undiluted and allowed to remain over night, a barely perceptible redness occurred, giving a maximum score of 1.3/8.0, which was classed as e slight irritant. The material proved capable of being absorbed through the skin in high doses when allowed to remain on the rabbit under a cuff. The mininum lethal does was somewhere over 2000 and under 3000 mgAg. This would fall into the "slightly toxic" range. The material is a alight aye irritant when applied undiluted to the rabbits' eyes and there was adld discomfort and alight redness. The maximum score waa 13/110 and the eye had returned to normal within three days. Rats survived six-hour Inhalation exposure to the vapors evolved at ambient temperatures following the passage of air through the material. No systemic effects were noted. We conclude from the above that accidental ingestion on the part of humans is not a particular hasard in view of the high oral lethal dose in rate. Similarly, single massive skin exposures should not be immediately hasardoue. The lethal dose obtained in skin penetration studies is such, however, that prolonged and repeated skin contact should be avoided because of possible systemic effects. In addition, prolonged and repeated skin con tact may lead to skin irritation. MQNS 090951 Miaa Elnor Parry -I- April 25, 1968 We alao feel that vapor Inhalation ahould be avoided whan the fluid ia heated to elevated teaiperaturea. Such exposure again relataa to prolonged or repeated exposures rather than short-term maaaive or acute exposurea. In the case of the latter, workmen would not voluntarily expose themselves to concentrations that are hasardous because of irritation of the respiratory tract. I have enclosed a copy of a summary of our interpretation of the data for Pydraul 312. If I can be of any further help, please let ms know. Sincerely, wj/ln anc. M. N. Johnson, M. D. Assistant Medical Director MONS 090952