Document e1mjkZw4ZB14ZDoQX7Y4gvQp4

Sn&utlu<il CIO -TEST JahovUvueA, Stic. 1010 FRONTAGE ROAD NORTHBROOK, ILLINOIS 60062 AMA COOC >1 TttIPHONC ?-f0)0 September 9, 1968 fSPlJI ia Mr. Elmer P. Wheeler Monsanto Company 800 N. Lindbergh Blvd. St. Louis, Missouri 63166 , C, Dear Mr. Wheeler: I am submitting a collection of protocols for studies with Aroclors. The studies proposed, with prices, are as follows: ' I. Rat Tissue Study Aroclor I 2 levels Aroclor II 2 levels Aroclor III 2 levels Toxaphene 2 levels Controls Total $2,700 tv Additional reference materials could be included for $600 per material (2 levels). This price is exclusive of analyses. If you choose for us to do all or part of the analytical work, we could work on a cost plus basis or we could pro vide you with a quotation after we have run through the method. We found no really useful information in our scan of the literature on the metabolism of chlorinated pesticides. I feel that wc can get much informa tion from analysis for tissue residues and from study of urine and feces collected from treated animals. It is not possible to quote for such studies in the absence of fore-knowledge of findings. This could be set up on a cost plus basis with provision to review after the expenditure of a defined sum. One should be able to at least define the problem on a budget of $5,000. HONS 091213 I Mr. Elmer P. Wheeler September 9, 1968 Page 2 II. Chicken Toxicity. Reproduction and Meat and Egg Residue Study Three Aroclors with common controls Exclusive of uvalytlcal costs $15,000 III. Mallard Duck Study-- ............. - _ . Three Aroclors with common controls Exclusive of analytical .costs $5,000 IV. 3-Generation Reproduction Study in Rats Three Aroclors with common controls $35,000 V. 2-Year Chronic Toxicity Study in Rats Three Aroclors with common controls $57,500. VI. 2-Year Chronic Toxicity Study in Dogs Three Aroclors with common controls $85,000 VII. Subacute Fish Toxicity Study We have not done such a study but we have built one apparatus which allows investigation of as many as five concentrations of one material plus controls simultaneously for extended periods ol time, starting with fingerlings and continuing through a reproduction cycle if this is desired. ' If one wanted only to measure the accumulation of test materials over a 90-day period, the cost, using 5 concentrations, would be ap proximately $1,500 per species for one material, exclusive of analyses. Extending the study through a reproduction cycle would cost an addition al $3,500. In any of these studies, material (urine, feces or tissues) could be retained for analysis to determine species differences relative to accumulation and metabolism. MONS 091214 r Mr. Elmer P. Wlicoler September 9, 1968 Page 3 The cumulative cost of the defined studies, exclusive of analytical costs and fish studies, amounts to $200,200. As Dr. Calandra has told you, biliings could be arranged to accommodate to your budgetary needs. -------------------- .Your comments on this program will be welcome and-should further per-. sonal discussions seem desirable, we will be glad to meet with you either here or in St. Louis. . ' Sincerely yours. Otis E. Fancher, Ph. D. Director OEF:DMS enc. MUNS 091215