Document dnM4REOpZwzZ7kOLj6EG2VVXR

June 22, 1953 Mr. B.Turner Ethyl Corporation 100 Park Avenue New York 17, New York Dear Bynum: f I am sending you herewith a brief memorandum with some financial data that, to me, seems pertinent to the matter which I discussed with you briefly on the 27th. Incidentally, I was kept so busy in California that I had no chance to prepare anything for your use at the June meeting of the Board of Directors of the Corporation, and I considered it unwise and unfair to send you a hasty and illconsidered letter. I have tried to be brief and to the point in the memorandum and to support my request of the Board, through you, with statements of fact and supporting data. I have taken for granted your familiarity with the general activities and functions of the Laboratory, as well as its place in the sun in the field of Occupational Medicine, both in research and professional training. More could be said, no doubt, but I do not like the idea of blowing our own horn , for among friends and associates in an enterprise of this sort, an elaborate memorandum, setting forth the details of our activities, would have some such sound. On the other hand, I send to you, as a supplement to the memorandum, for your own information (if you have time to read it) and for any other use that it may be to you, a fairly brief historical statement, in which are set forth the main facts of the background and activities of the Laboratory. I appreciate very much indeed your expression of your personal approval of my proposal, and I hope it will be looked on favorably by your associates on the Board. In connection with the possible feeling on the part of the Board that this activity may continue indefinitely to make demands upon them, I think Z might point out that this is not so much the expansion of our activities, but the modification of them:to meet the specific requirements of industry in certain directions. In effect, it is the rounding out oi activi ties in which we have been too little represented in the past. Moreover, with this extension of our building, we have acquired just about all of the space that can be granted to us in this medical center. There is, in fact, no space remaining. life have planned with great care, therefore. N9863 Mr. B. Turner 2.- ' June 22, 1959 to make as effective use of it as possible. This, Z think, covers the situation as well as X can, and I put the matter in your hands. Sincerely yours. Robert A. Kehoe, M. D. RAK:ss Enclosure .r 0003347 BRIEF SUMMARY OF MEMORANDUM X. Since 1949 need has developed for further facilities because of: 1. New technological trends in industry, among which those concerned with nuclear radiation have considerable importance, requiring .f us the creation of a division of biophysical research 2. Intensification of industrial chemical development and production, together with tightening of regulatory mechanisms, requiring a great increase in the scope, and fairly radical change in the procedures of toxicological research* 3. Requirements of collaboration in work of local government. The provision of facilities for forensic medicine (pathology and toxicology) as the armamentarium of the Coroner of Hamilton County, at the expense of Hamilton County for rental of a space for at least ten years, has been implemented by an appropriation of $200,OCX) toward the cost of these facilities, these to be owned, however, by the University of Cincinnati. II. The requirements of Ethyl Corporation during the past two years has put some strain on the Laboratory and threatens to occupy an undue proportion of the toxicological facilities. If; is believed that these requirements will continue for years to come, and that the ability of the Laboratory to meet some reasonable proportion of the needs of other industrial sponsors (and so to broaden the bases of both research and financial support thereof) depends upon the early enlargement of the facilities. N9863.01 0008348 Additional facilities designed to meet present and anticipated needs are estimated to cost approximately $1,200,000. These involve an additional space of approximately 40,000 square feet at a cost, together with basic, fixed equipment, of $30.00 per square feet. The share of Ethyl Corporation toward the provision of these additional facilities, by themselves, could be estimated at $340,000 in terms of the projected and probable share of the Corporation in their use for research and for housing the Medical Department. In view of tlie previous history of the Laboratory, and the contribution of financial, technical and moral support made by Ethyl Corporation over the years, toward its development, it is suggested that a contribution of $175,000 might be equitable. On the basis of the composite of sums which may reasonably be set opposite the names of other industrial sponsors, and which, in some part, have met with favorable con sideration, it is believed that the necessary funds can be obtained in rough accordance with our estimates. If Ethyl Corporation should believe it wise, in its own interest, to limit somewhat the breadth of the base of general industrial participation in this project, no objection in principle is offered at this time to a contribution beyond the sum suggested. Indeed the suggestion is intended merely as indication of one view of the matter, and not on a policy of the University of Cincinnati. The officials of the University, as well as, and in particular, the Director of the Kettering Laboratory, have only the highest respect for -3- the policies of Lthyl Corporation, in tta relations with the University, as they have been expressed ana carried cut over the years. Jane 22, 1Q59 Kofoert A, Kahue, M.D. Director. The Kettering Laboratory 000 0.!.)U asaoaVNDUM ON NEED FOR ADDITIONAL SPACE AND FACILITIES IN THE KETTERING LiBaSATOK? During the period uince 1040, when the last prior najor addition to the Laboratory was completed, there have been several developments which Ixave added to the need for further facilities and have created new demands. Indeed, with the completion of the new wins i 1949, the requirements for space, which had continued to develop during World War II but could not then be net, had reached such a point that when new apace had been provided it ms fully occupied ut once. Nothing of significance, by my of space available for anticipated developments, remained, unoccupied. This, has not, until recently, been a serious handicap, for it necessitated the 'msst cccaozaical use of the space and other facilities, and prevented any trend in the direction of extravagance. This point is referred to thus early in this memo for the good reason that the recent sharp increase iu attention paid to occupational health within industry and in other universities has provided a degree of "competition'1 in the field of research utd graduate Instruction, which has not been once mitered previously by The Kettering Laboratory. It is clear,from this and other reasons, that ita operations must be conducted with efficiency and economy, as well as with the productivity which, wo believe, it has shown in the past. The principal developments which have influenced our activities and have called for additional facilities, are the following:- 1. Hew technological trends in industry. The applications of new types of energy in industrial production have created new haaAv&tf elucidation and control of which are in the realm of biophysics. At the same time, the use of physical tools (radioisotopes etc) in the laboratory has developed to a point that makes mandatory their further use in the N9863.02 )-* 0008351 -2- elucidation of biochemical and toxicological problems. The laboratory has found it necessary, therefore, to establish and implement a division -'A' biophysics, within which the physical and biological techniques concerned with noise, high frequency radiation, atosiic radiation, can be applied with safety and increased scope. 2. Intensification of old technological trends, with modification. Through further ra>Ac strides in industrial chemistry, isany new materials unci ..recesses have come into existence. These, in themselves, multiply occupational and public hazards, and require extensive facilities for toxicological investigation. In addition, the concern of our informed people (and some uninformed, or insufficiently informed people, as well) aoout the threats offered by modern technological dovelopaentc to the health of both the working and the genera1 population, has undergone a great increase in recent years. This has intensified the demand for research, and has altered its quality,with both beneficial and detrimental effects. On the one hand, the need for improvements in the practice of industrial medicine and hygiene has required that the scope and depth of research in industrial toxicology be increased. The mechanisms of action of injurious agents, both chemical and physical, mat be explored and elucidated, ;uia not merely cataloged by their capacity to cause injury and death. Get the other hand, the powers and responsibilities of curtain governmental agencies, notably the Food and Drug Administration, have been expanded greatly by legislation, and this expansion of responsibility has been translated into an elaborate set of specifications for the investigation of the hazards which reside in the additives to food cr to the contaminants of food. That some such development was inevitable is somewhat beside the point of these remarks. The fact is that the present detailed Epccifi- the cations of F.D.A. increase eixonsously/deraand for facilities for toxicological 3 investigations, and greatly multiply the expense of industrial operations in relation to the production, preservation, processing, packaging and distribution of food in the U.S.A. We are caught in this situation, and despite the relatively unproductive nature of these investigations, pursued as they now must be, without either imagination or real scientific incentive, we must be prepared to meet some of the needs of our industrial sponsors. The demand for facilities in this phase of our work is great, in that elaborate feeding experiments carried out with large (prescribed) numbers of animals, tie up expensive space (which must be meticulously sanitary and well air-conditioned) for two or more years at a time. 3. Adaptations to other needs of the local community. Some years ago, certain of the facilities of The Kettering Laboratory were made available to the government of Hamilton County. The chief of the division of pathology, at the request of the County Coroner, became the Coroner's pathologist, and the toxicological facilities, including those concerned with analytical determinations, were put at the disposal (within contractual J.imits) of the Coroner and the County Prosecutor. This feature of our work, which has served to eliminate the amateurish and political flavor of this type of forensic medicine in Hamilton County, has met with favor, and the County Commissioners have desired to establish adequate physical facilities (morgue, necropsy rooms and Instruments, separate, legally privileged facilities for toxicological investigation, and administrative offices) in the Kettering laboratory at their expense (the capitcl sum of *2C0,000.00 in lieu of rental for 10 years, has been made available to the University of Cincinnati,whose property these facilities will be.) 4 The developments referred to above have created an immediate need for additional facilities, which have been worked out with an architect, in collaboration with responsible representatives of the University of Cincinnati. The north-south wing of the present building is to be extended southward for an additional 140 ft. Five floors (approxissately 40,OCXS sq.ft) in harmony with the present structure of the laboratory (but with certain economical features) will bo built at an estimated cost of $30.00 per cq.it., including the cost of air conditioning equipment and certain other ttciss of fixed, operating equipment. (Since all space (west of 3 floors) cot aside for animals uid for experiments involving animals must ho ucjaymu to main tain very nearly ideal environmental conditions, all of the space, with- the exception of certain specific technological 2<> horntori, vdll be airconditioned.) With specific reference to the situation of Ethyl Corporation in f-a-i 3 development, certain facta and svggc-f.'ti-.,ns -re incorporated in <-;u a- iho attached sheets of financial data. An additional point nay be naan, ft that the requirements of Ethyl eurocratIon, in connection with the ccvclopuent :> new products nnd the exploitation of curtain others, Jmve put a heavy burden on the Laboratory during the past two years, .nod especially in 159, The work now in progress could bo expanded or expedited to absorb isoot of the personnel and facilities of the toxicological division. This, obviously, would not be wise, but if it is to be avoided now and in tfco future, wc- must have some margin of resources that will enable us to respond to the sudden or unforeseen requirements of our sponsors. There stews little likelihood that ouch demands on the part of Ethyl Corporation will diminish during the next ten years or more, .if the history of these developments repeats itself or follows any sort of comnar.'.ule trend, Basic information as to the rolo of /!, 0008354 5 certain metallic elements and compounds discharged into the atmosphere frea various types of fuel-burning equipment will b required as background for the public safety in connection with the use of these materials. In addition the continuing search for new aheadcal products, oast the development of these products will Ueep ua (ar some other investigative group) occupied to a wry considerable extent. 'A'e might anticipate that no less than cne-fcurth of the facilities of the Laboratory would be engaged in work for ethyl Corporation for yearn to come, and that approximately one-fourth of its budget would derive fron that nourco. On this basic, on might believe that one-fourth of ths cent of the j.dditicn-ai f.-cils.ilua should bo allocated to 'Ethyl Corporation. It is nor through ony v/inh or :iavd oon the part of tho Sirector of Clio Kettering Lib oratory (or on the part of the 'Juivoroity Sffieiais) to avoid any undue influence on the scope of tho activities of The Laboratory vsfelch might be eaorciscti by tfcyl Corporation, that the suggestion his been made that Sthyl*3 chare in -ho :`iranging ox th further facilities .oxy well be significantly less than vno-fourth, ..other. It in because of the- recognition of the beneficial r---.lt th,,t ethyl Corporation has played in the past, that it has seemed e^uitable- to broaden che ease of the financial support derived from industry, end to lighten somewhat, tho proportional burden mi Lthyl Corporation at this time. If ethyl's officials should fool that this la unnecessary, or that the Corporation would prefer' not to diiainish its atahe in the Laboratory ( and perhaps its right to call upon the Laboratory, in need, although, it does rot follow that this right would be diminished), no possible- exception could >>r would be taken to their '/.tew and its implementation. . The suggestion which has Loon offered as to the allocation of cost to the present sponsor of The Laboratory would b 0008355 -6- totally uncalled for were it not that some basis for allocation is required for our own purposes in assembling the funds which would appear to us to be required to accomplish our purpose. Jane 22, 1959 Robert A. Kehoe, M. D. Director of The Kettering Laboratory I6Z, 0008 85 & MEMORANDUM OK NEED FOR ADDITIONAL SPACE AND FACILITIES IN THE KETTERING LABORATORY During the period since 1949# when the last prior major addition to the Laboratory was completed, there have been several developments which have added to the need for further facilities and have created new demands. Indeed, with the completion of the new wing in 1949, the requirements for space, which had continued to develop during World War II but could not then be met, had reached such a point that when new space had been provided it was fully occupied at once* Nothing of significance, by way of space available for anticipated developments, remained unoccupied. This, has not, until recently, been a serious handicap, for it necessitated the most economical use of the space and other facilities, and prevented any trend in the direction of extravagance; This point is referred to thus early in this memo for the good reason that the recent sharp increase in attention paid to occupational health within industry and in other universities has provided a degree of ncompetition" In the field of research and graduate instruction, which has not been encountered previously by The Kettering Laboratory. It is clear, from this and other reasons, that Its operations must be conducted with efficiency and economy, as well as with the productivity which, w believe, it has shown in the past. The principal developments which have influenced our activities and have called for additional facilities, are the followingj - 1; New technological trends in industry. The applications of new types of energy in Industrial production have created new hazards, the elucidation and control of which are in the realm of biophysics. N9863.03 0008357 - 2- At the same time, the use of physical tools (radioisotopes etc) in the Laboratory has developed to a point that makes mandatory their further use in the elucidation of biochemical and toxi cological problems; The Laboratory has found It necessary, therefore, to establish and implement a division of biophysics, within which the physical and biological techniques concerned with noise, high frequency radiation, atomic radiation, can be applied with safety and increased scope; 2. Intensification of old technological trends, with modification Through further rapid strides in industrial chemistry, many new materials and processes have come into existence. These, in tneraselves, multiply occupational and public hazards, and require extensive facilities for toxicological investigation; In addition, the concern of our informed people (and some uninformed, or insufficiently in formed people, as well) about the threats offered by modern tech nological developments to the health of both the working and the general population, has undergone a great "intiretase in recent years. This has intensified the demand for research, and has altered its quality, with both beneficial and detrimental effects. On the one hand, the need for improvements in the practice of industrial medi cine and hygiene has required that the scope and depth of research in industrial toxicology be increased; The mechanisms of action of injurious agents, both chemical and physical, must be explored and elucidated, and not merely cataloged by their capacity to cause injury and death. On the other hand, the powers and responsibilities of certain governmental agencies, notably the Pood and Drug Administration, have been expanded greatly by legislation, and thi3 expansion of jfl, 0008358 3 responsibility has been translated Into an elaborate set of specifications for the Investigation of the hazards which reside in the additives to food or to the contaminants of food; That 30me such development was inevitable is somewhat beside the point of these remarks; The fact is that the present detailed specifi cations of F; D;A; increase enormously the demand for facilities for toxicological investigations, and greatly multiply the expense of industrial operations in relation to the production, preservation, processing, packaging and distribution of food in the U.S.A. We are caught in this situation, and despite the relatively unproductive nature of these investigations, pursued as they now must be, vrithout either imagination or real scientific incentive, we must be prepared to meet some of the needs of our industrial sponsors. The demand for facilities in this phase of our work is great, in that elaborate feeding experiments carried out with large (prescribed) numbers of animals, tie up expensive space (which must be meticulously sanitary and well air-conditioned) for two or more years at a time. 3. adaptations to other needs of the local community. Some years ago, certain of the facilities of The Kettering Laboratory were made available to the government of Hamilton County; The chief of the division of pathology, at the request of the County Coroner, became the Coroner's pathologist, and the toxicological facilities, including those concerned with analytical determinations, were put at the disposal (within contractual limits) of the Coroner and the County Prosecutor; This feature of our work, which has served to eliminate the amateurish and political flavor of this type of forensic 0003859 medicine in Hamilton County, has met with favor, and the County Commissioners have desired to establish adequate physical facilities (morgue, necropsy rooms and Instruments, separate, legally privileged facilities for toxicological investigation, and administrative offices) in The Kettering Laboratory at their expense (the capital sum of $200,000.00 in lieu of rental for 10 years, has been made available to the University of Cincinnati, whose property these facilities will be). The developments referred to above have created an immediate need for additional facilities, which have been worked out with an architect, in collaboration with responsible representatives of the University of Cincinnati. The north-south wing of the present building is to be extended southward for an additional 140 ft. Five floors (approximately 40,000 sq;ft) in harmony with the present structur of the Laboratory (but with certain economical features) will be built at an estimated cost of $50*00 per sq.ft., including the cost of air conditioning equipment and certain other items of fixed, operating equipment. (Since all space (most of 5 floors) set aside for animals and for experiments involving animals, must be designed to maintain very nearly ideal environmental conditions, all of the space, with the exception of certain specific technological laboratories, will be alr&onditioned.) June 22, 1959