Document dn0eERezYv2aJjDzOpVE8aeB5

*> AR226-2835 Copies to: E. I. du Pont d j Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine HASKELL LABORATORY REPORT NO Haskell No. 7942 PRIMARY SKIN IRRITATION AND SENSITIZATION TESTS ON GUINEA p t o c S r ~ S 2 S - ^ d2 i S l 2 ' ^ -- -- - _ _ Organic emicals Department, Jackson Laboratory . * <~o.05, f test material in distilled ,,.ter. F,,ll,,,,i,,g . t ,, o -Lek re.freii^d ^ * 1 f ' " ! f a l-W w l M i o n (,,t/vol) sensitization by applying, and lightly rubbing in 1 dron AuO i animals were challenged for material in distilled water on thf shaved intfct should s k L I in " * Slution < * 1 ) off test received similar applications at the time of challenee to nrmHHo Sa?UP ^ 10 Prevl-ously unexposed guinea pigs on skin of similar age. challenge to provide a direct comparison of the challenge reactions Results: Concentration in distilled water Primary Irritation Test 257. 107. 257. 107. 24 Hours 48 Hours Challenge Test 10 Neg. 10 Neg. lu Neg. 10 Neg. 24 Hours 48 Hourr Nether ofAnimals Sensitized** SummaryT T tJ B B - 10 Neg. 10 Neg. ----- 10 Neg. 10 Neg. \0Jf/J1.U0 10 Neg. 10 Neg. 10 Neg. 10 Neg. 25U and d i ^ e d Uaer! irrltatin or M i t i g a t i o n when tested on guine'a pig skin at" concentrationsof Company Sanitized. Does not contain TSCA CBI 2 ** d i " l d ' moderate strong erythema; +-H-+ = erythema plus edema: +++++ = necrosis Sensitization is defined as a two-step score increase (-H-) at challenge over the response expected from same amount applied initially or on the concurrent controls P exPected from the NB E3281 p. 50 OLD/ smw Date: May 8, 1973 Report by: 0. Louis Dashiell Approved by:_____ Charles F. Reinhardt Assistant Director Qofqpany Sanitized. Does not contain T S C A C B l