Document daapop62GKQD5Q5OXrqyZJZQG

Z 6T 000 et b r i ' W W CONFIDENTIAL MEMO TO: F, E. FRENCH, FROM : B. C. MC KOSICE DISCUSSION OF FtOOBQCHEMICALS WITH 3M On July 20, S. N. Boyd, G. L. Kennedy, F. J. Marascia, B. C. McKuaick, R. E. Read, and. R. D. Richardson of Du Pont net in Chicago with F. D. Griffith, L. C- Kxogh, R. A. Prokop, and F. A, Obel of 3M. Richardson described measurementa of organic fluorochemicals in blood of flucfcosurfactant production employees at Chambers Works*, In contrast to experience at 3H, concentrations are normal, A retroactive study of medical records found no adverse health effects. The blood analysis program has been discontinued. Kennedy described Haskell's subacute toxicity studies of CD&P fluoxochemicals*. They are consistent with 3M animal data. Prokop of 3M dgacrihsd*a gas chromatographic method to determine perfluoroBctanplc acld(jHHB|jLs blood, urine, liver, and other biological materials. It can measure as little as 1.5 ppb. A paper has been pre pared (copy attached) that should appear in about six months. Ubel, the 3M medical director, said that no advers|^liveg^effects or other health effects have been found among employees ln|MMHP|n>eratlons. Blood levels of ozganofluorlne In employees have changed little despite steps to lessen exposure. Blood levels of employees moved to locations outside the fluorochemical area have dropped only slightly, although measurable amounts of organic fluorine is excreted. This was illus trated by data on an employee mho bad been in the fluorocheulcal area for 15 years and bad the highest blood level of any (Table I). (''Transparencies attached to copies of French, Simmons, & Reinhardt.) B E T T E T H IN G S EOFt B E T T E R LIVING . . . T H ftO U O H C H S M I S T & V Company D m notcontainTSCA CBI 000193 MEMO TO: F. E. FRENCH, JR. -2- TAttT.K T July 23, 1979 ORGANOFLPORIHE Of ORE EMPLOYEE Date July 76i Oct 77 Apr 78 May 78 Blood Coccentxation. ppm BF J L l . V M P I 39 0.05 40 .03 71 67 53 Urine Cone., itg/24 hr. KF (At this point, he was transferred to another area) June 6, 78 June 13, 78 July 78 Aug 78 Oct 78 Jan 79 Apr 79 66 71 66 55 59 45 47 484 272 160 175 160 220 3M got blood samples from 8 peasants In a Chinese village 30 miles from Canton. The ogrsnic fluorine was siginficantly lower (0.004-0.017 ppm), than values fpund in developed countries (e.g., 3M found 0.002-0.13 in 106 members of the general U.S. population). tlbel said that a University of Minnesota professor is doing an epidemiology study of 4000-5000 employees mho have worked at the oldest and biggest 3K plant manufacturing fluorochemicals. Nothing noteworthy has shown up, but the study has a long way to go. a A year ago all employees in fluorochemical manufacture were told the results of the blood study. 3M recently told theta about it again. About 60 employees In the fluorochemlcal area have had blood organic fluorine measured. All who have been found to have elevated organic fluorine blood levels have been informed of the fact and told that 3M doas not know what It means, but chat no adverse health effects have been related to it, the employees have taken the information calmly. `lfffth, 3M manager of toxicology, reported deca on 90-dy studies of [in rets and monkeys (see attachment). The effects were similar to what : saw with similar materials. Thus, the liver was the mein target organ. There was no significant difference in effects between male and female rats, but males retained about 100 times m o r e f j n M Q Griffith said he would send me details on this. Compmy Sanitized. D m coniato TSCA CBf 000194 'v> * MEMO TO: F. E. FRENCH, JR. -3- July 43, 1979 3M will start a matabgj.ism stggy of radiolabeled 40 rats soon This may show w b e r e ^ B y ^ igjbeing stored la the body. Studies ofA k j M d u s t on animal skin Indicates It dess not penetrate the skin easily. 3M indicated interest in another review in about a year or whenever one company has interesting results. BCM/bjd I i I t i 1 tsicaear 00l9s