Document daZQNLOV9jyEvqwNOXw6o8pw0

2pco 3M @-33 SKaatheVriinsePEr.esRiedcentt, PhD. 3nMd ESnuvlilryonSmeervnitcaels Technology gGH-R 1102-00373 LEH - 9B0ui0ldBiunsgh4A2.v3e6n.e36 S Raansr ss me Ge343L CERTIFIED MAIL October 30, 2002 AR 26_ 1/38 Contain NO CB) o 5 Document Processing Center (7407M) OEfPfAiceEaofsPt--olRloutoimon6P4r2e8veAntttin:onSaencdtiToonx8i(ccs) U12S00EPPeAnnsylvania Ave, NW Washington, DC 20460-0001 son =o ih i=S uh 5 `TSCA (E) SUBSTANTIAL RISK NOTICE ON: Reference SEHQ ~1180-373, 374 Perfluorohexane sulfonate potassium salt Dear Sir: R3eMprroedcuecnttliyves/pDoenvseolroepdmaennt"aOlraTlox(iGcaivtaygSec)reCeonmibnignTeedstR"eSpteuadtyedofDpoesreflTuooxriocihteyxawniethsutlhfeonate Lpaobtoarsastiourmiessa,ltH(oPrsHhSa)m,, TP-e7n7n0s6y.lvTanhiea.stuTdhyewparselciomnidnuacrtyeddraafttArregsuusltReisncelaurdceh cCehratrailnesfiRnidvienrgs that appear appropriate for TSCA section 8(e) submission. Parental male rats were dosed for at least 42 days. Parental females were dosed for approximately 60 days. adverse effects noted in No PFHS related effects were observed in the parental male rats exposed to PFHS included: parental females. (a) an increased The arbastooluftore bloivtehr twheei3ghatndan10inmc/rkega/seddaylidvoesre-st;o-(bb)oddye-cwreeiagshetdraavteo;raagnedvaaliuveesr-ftoor-cbhroaliens-tweerioglhitn t(dh)e m0i3n,im1a,3l atondmo1d0emragt/ekge/ndlaayrgdeomseenst; o(fc)cdeenctrrielaosbeudlatrrihgelpyacteroicdyetsesininthtehe103 magn/dkg10/dmagy/kdgos/ed;ay dtohseetsh;yraonidd(gl)ainndcsroefasmeadliensciindetnhceeo3fantdhy1ro0imdgf/oklgli/cdualayrdcoeslelss.hyTpheerrterowpehryeannod shiygpnesrpolfasia in neurological, developmental or reproductive effects. 55 = oom 2 0.23 2 22 zEt 20 == a A copy of this study report will be sent to EPA when received Aothperrevcioomupsoluynrdesp,ordteemdoEnxsptlroartaetdorsyo2m8e-odfatyheOsraelsTaomxeicaidtvyeSrtsuedeyffcecotnsd. ucSteed LweitttherPfFrHoSm,3aMmotno g 8(e) Docket, August 21, 2000 (requesting the SEHQ 1180-373, 374 dockel). this and other studies to be moved from AR-226 to fun 000811850N 1 OfficeofPollution Prevention and Toxics Page No.2 October 30, 2002 Please contact Dr. John Butenhoff, 3M Corporate Toxicology and Regulatory Services, 651-733-1962, for further information. ) Lets 2 od Katherine E. Reed StaffVice President, Environmental Technology and Safety Services &