Document daVDDoaJgMvXq1qdrZ6g2a9JG

FILE NAME: Texaco (TEX) DATE: 2003 DOC#: TEX027 DOCUMENT DESCRIPTION: Tables of Contents & 1 Article by Heuper found in Texaco Library r I V E D i! !.^ >ij JLj 1 2 OCT17 2003 3 P A4GtE-1 4 5 6 7 SUPERIOR COURT OF WASHINGTON FOR SKAGIT COUNTY 8 VIRGINIA JAMESON, Individually and as Personal Representative o f the Estate o f No. 02-2-01069-8 9 RAY JAMESON DECLARATION OF 10 Plaintiffs, MIKE CHASE 11 V. 12 TEXACO, INC. e t al. 13 Defendants. 14 15 I, MIKE CHASE, declare and state as follows: 16 1. I am over the age o f eighteen and make this statement based upon peisonal 17 knowledge. 18 2. I am an investigator in Beaumont, Texas. 19 3. Recently, I w ent to the library o f the Lamar University in Beaumont, Texas to 20 look for volumes from industrial hygiene journals purported to have been donated by the Texas 21 Company to Lamar University. 22 4. In the course o f m y research I was able to locate several volumes dating from the 23 early 1950s o f the journal called Archives ofIndustrial Hygiene and Occupational Medicine. DECLARATION OF MIKE CHASE. -1 caowmmmwa t utrci KidomiPmD-PB: opHucflCrtNSB.* Bergman S enn Pageler s F kockt .O . BOX 2010, 11530 Vittimi Hjranu 6H vmnoh, WA 96070 TKtiEMW* 206.463.440B FaCbJkZLS: 2 0 6 .4 6 3 .4 4 7 0 1 According to the title page o f each volume, this particularjournal was published by the 2 American M edical Association. 3 5. In the volumes, the title pages and, in some instances, the table o f content pages, 4 contained the following information appearing to be in the form o f an ink stamp: "THE TEXAS 5 COMPANY LIBRARY RESEARCH LABORATORY PORT ARTHUR TEXAS." 6 6. Attached to this declaration are true and correct copies o f title pages and table o f 7 contents pages o f five volumes o f die Archives O fIndustrial Hygiene and Occupational 8 Medicine spanning the years 1951 to 1955. I personally located and had copied these pages 9 directly from volumes that were on the shelves in the Lamar University library, a public 10 institution in Beaumont, Texas. 11 7. I declare that the foregoing is true and correct under penalty o f perjury. 12 DATED this 17th day o f October, 2003 at Beaumont, Texas. 13 14 fl/ljJ i' ___________________ MIKE CHASE 15 16 17 18 19 20 21 22 23 DECLARATION OF MIKE CHASE. - 2 Bergman Sen Pageusr t Frock? P.O. BOX 2 010, 17530 VXsHoh SW VXflBOM, HA 90070 TsumONEt 200.(03.4408 E M nm st 200.403.4(70 . A.# A# a r c h iv e s of Industrial Hygiene and Occupational Medicine e d it o r ia l bo ard PHUTI* MUNHEH, CHW 011 S S U tt * .Street. PorHo I t TUBO)IIIHG r . BATCH, lAilsibuiAh. MMKitT a. aojos, cinerontai IBUf PUOIJR. Oleato), CIH. ruAHK t w u i vautt SHILNK A, fA ITTi U*W#i WILLIAM A. \WTBH, *AcO *r. N, T, JAME) It. BTBSWJfH. Tludiokr, . Y. ' MCHATID I. PLUNKCTI, M.D., CblMSA Muiutg lUr Volume 3 1951 FUBUSnEBB AHE&IGOI MKUICAL ASSOCIATION CHICAGO ID, ILL. CONTENTS OF VOLUME 3 JA N U A R Y 1951. N U M B E R 1 ttioerim ental Studies of Asbestosis. A rthur J. Vorwald, Ph.D.(J ^ 5 D urkan and Philip C. P ra tt, M .D , Saranac Lake, N . Y>. PACE A ir Pollution in Pittsburgh, Sumner B. B y , S.B,, P ittsburgh................................................ 44 Toxicologic Studios of Compounds Investigated for Use as Inhibitors of Biologic Processes. Anthony M. Ambrose, F b -D , Albany. Calif.: I I I . Toxicity of Propylene Glycol Dipropionate........ ..................... .......... ................. 48 IV , Toxicity of l^-Dim thyl4,6-Bxs(Chlorom ethyl) Benzene............... ................. 52 investigation of Occupational Dermatoses in tfs Citrus F ru it Canning Industry. Donald J. lnV p tS J w rh**, l T j P au l C. Campbell J r , H D .} H a iry N . Doyle, B .S , Washington, D . C , and J . M. hfeDonuld, M .D , Jacksonville, F la...................... . . . . . . . . . . . . . . . . . . S7 A' Study of W orkers Exposed to the Insecticides Chlordan, Aidrin, Dieldrin. Frank Princi, M JD, Cincinnati, and George H . Spurbcek, M J 5 , Pierre, S. D.................................. . 64 An Analysis of Existing Types of Small-PJant Health Services in Northeastern United . States. R. B, O'Connor, M .D , B o s to n ..........................................................- ..................... 73 Experimental Beryllium Granulomas of the Skin. F ran k R. D utra, M .D , Cinckmati.......... 81 Meteorological Technics in A ir Pollution Surveys. M erril Eisenbud and W . B. H arris, New Y ork................................................................................. ................................................... #> New Instruments and Technics: A Modified A ir Sam pler Employing Fiberglas-* F . W . Schl and B. J . Havens J r , . Hartford, Conn.......................... 98 Abstracts from C urrent L iterature......................................................................... 101 News and Comment.......... ............................ ..................................................................................... 115 Book Reviews................................................................................................................................ 120 F E B R U A R Y 1951. N U M B E R 2 A Rapid X -Ray Diffraction Method for the Determination of Q uartz in Industrial Dusts. Lawrence L. Sehmelzcr, B .S , Berkeley, C a lif............................................ ............. 121 Significance o f the Exercise Tolerance T est. W illiam F . R outer, M .D , Baltimore................ 129 A Study of Nitrogen Oxide Concentrations D uring Arc Welding. Leslie Silverman, Sc,D. (Indust. H yg.) and S. 1. H usain, S .M , Boston.............................................................. . 155 Symposium on the Dynamics o f Industrial H ygiene; Presentation of an Unidentified Occupational Case H istory. Robert J . Hasterlik, M iD , Chicago..........................; ................... ....................................................................... 147 Surveying the P lant, D . J . Lauer, M .D , Cincinnati............................................................. 150 Studying the Environment. F . E . Adley, Richland. W a s h . . . . . . .................................. 153 Chemical Analysis. Francis R . Holden, Ph,D.(Chem.), San Francisco........................... 159 Maximum Allowable Concentrations. H . H . Hudson, M JD , Nashville, T a m ................... lfii Medical Control. Robert A . Kehoe. M D , O o c m n a ti.,.............. .................... ............... ifi$. The Engineering Control of an Occupational Health H azard, B. F, Postman, M ,E, New Y ork......................................... ............................... ......................................... . ..7 7 . 159 Hi CONTENTS OF VOLUME 3 FEBR U A R Y --Continued PACE Symposium on How Industrial Medicine Can Meet the Needs of the American W orker: T h e Viewpoint of the Personnel Administrator. H iram S. H all, A .B , LL.B ,, New Y ork 173 T he Viewpoint of the Sociologist Relnhard Bendix, Ph.D ., Berkeley, Calif................... 177 T he Viewpoint of the Psychiatrist. K arl M. Bowman, M -D , S an Francisco............... . 181 T h e Viewpoint o f the Physician in Industry. H enry H . Kessler, M.D-, Newark, N . J L . 185 The Viewpoint of die Union. H a rry Read, W ashington, D. C ................... ................. 188 T he Viewpoint of Religion. Richard Henry, B.D., Knoxville, T enn............... ................192 New Instruments and Technics : A Lightweight Pow er Supply for an Electrostatic Precipitator. John K . Brown, B.S. (Chem. E ngr.) ; Andrew D. Hosey, B.S.(Cftcro, E n g r,), and H erbert H . Jones, ' B ,S ,(C E .), O n clm u ti.............. ......................................... -,............... ......... - .............. 198 Abstracts from C urrent L iterature.......... ...................... ........................................................... 204 News and Comment........ , .................................. 1 . . . . ............. ......................................................... 224 1 Book R e v ie w s ....,,........................................................ .................................... ............................. 226 MARCH 51. NUMBER 3 Effects of Noise on Human Behavior and Communication. H allawell Davis, M .D,, St. Louis 227 Noise In Industry: Report of a Conference H eld D uring the T enth Annual Congress on Industrial Health, of die American Medical Association, in N ew York, Feb. 20,,t 1950. ' James H . Sterner, hf-D., Rochester, N . Y , and Stacey R . Guild, P h .D , Baltimore, Co-Chairmen .................................................................................................. 232 Physical Medical and Rehabilitation Therapy of H and Injuries. H erm an J . Flax, M .D , San Juan, Puerto Rico........................................................................ *............................. 236 Occurrence of D D T In Human F a t and Milk. Edwin P . Laug, P h J> .; Frieda M. Kunze, B .S , and C, S. Priekett, M .S., W ashington, D. C................. *............... .............................. 245 Hydrogen Sulfide Poisoning m Shale Oil Industry. Gunnar Ahlborg, M -D , Stockholm, Sweden ............... 24? Treatment of Lead Poisoning with Sodium C itrate: Report of F our Cases. H arriet L. Hardy, M .D , Boston; Ronald C. Bishop, M .D , Roxbury, M ass, and Clarence C Mai oof, M .D , Boston............................................................................................................ 267 A Pilot Program for Cancer Detection in Industry. Benjamin N . Berg, M .D , New Y o rk .. 279 Toxic Effects of Exposure to Vapors of Aliphatic Amines. H einrich Bricgcr, M .D , and W illiam A_ Hodes, A .B , Philadelphia....................... ......... ....... . . . . . . . . . . . . . . . . . . . . . . . . 287 Compensation Aspects of Myocardial Infarction in Industrial Medicine. James H . Thompson, M .D , San F ra n c is c o -............... .................................................................. 292 Report on Industrial Hygiene in the W estern Zone of Germany. Irving R. Tabershaw, M .D , New Y ork...................... 298 New Instruments and Technics: A Smalt Self-Contained Laboratory for Radioisotope Studies hi Experimental Animals. Reidar F . Sognnacs, D.M JO, F b .D , and James H . Shaw, P h .D , Boston................. 316 Abstracts from Current L iterature.............................................................................. ...................323 News and Comment................................................................................................ 338 Book R e v ie w s........................... 338 A P R IL 1951. N U M B E R 4 Report on a Country-Wide Study of Silicosis in the Metal Minci of Japan, Mikio Yama moto, M T ), Tokyo, J a p a n ,...................................................................................................... 339 Present Condition of W orkmen's Compensation Laws, and Possible Changes. Marshall Dawson. Washington, D . C . ....................................................................................................350 On the R Traci Effects O eatioi Belle Value an Arth' Evalua tin Ah In Health ai ingto Rose Abstract! News a r Book R e Fatalit. Jack A Toxi Sha Crit Aiding i Air Fio Ser Pio Chroqic Ph. A lt Activlti Wa Cadmiti Investii Da Abstrai News : Chroni T Case H; Five C im W ChronSpenti tu J TAGS irk 173 ... m . . . 181 ... IBS . . . 188 . . . 192 B.S. 198 *fte 204 224 22$ Louis 227 ** on 1950. more, ........ .2 3 2 M .D ., ...........236 Kimze, . , ... . 245 f ,i 247 rriet L. Y o rk .. 279 X ), and 287 sues H. fbenhaw, 298 316 323 338 338 loo Yama339 k 'Marshall 350 CONTENTS OP VOLUME 3 v APRIL---Continued PACE n the Retention of Air-Borne Particulate* in the Human Long: II. H . D, Landahl, T . N. Tracewell and W . H . Lassen, Chicago................................................................................. 9 effect* of Employment on th e Course of H eart Disease. T h e Steff o f % W o rk Clmssifi* cation Unit, A dult Cardiac Clinic, T hird (N ew Y ork U niversity) Medical Division, Bellevue Hospital, New Y o jk ...................................................... .......................... .............. 36' Value and Operation of an Industrial Medical Program . M ax N . Howard, M.D., and A rthur E . H oag, M.D* New Y o rk .......................................................................................... 375 Evaluating Trichloroethylene Exposures by Urinalyses for Trichloroacetic A dd. Axel . Ahlmark, MX.. Stockholm, Sweden, and Sven F orem an. M.D,, Tomteboda, S w eden.. 385 Health and Air Pollution: A Study on a Limited Budget, H arry Hermann, M.D,, W ash ' ington, D. C .; W . F. Reindollar. ScX>, Baltimore; Hugh P . Brinton, Ph.D., and Rosedith Sitgreaves, M.A., W ashington, D. C -.................................................................... 399 Abstracts from C urrent L iterature.................................................................................................... 408 New* and Comment............................... - .......................*......................................*...........................44Z Book Reviews................................................. .................................................................................442 M A Y 1951, N U M B ER S Fatalities from Hydrogen Sulfide In W ells. John M. McDonald, M .D , and A . P . McIntosh, . Jacksonville, F la..................... .................................................. *............................................. 445 A Toxicological Study of Some Polypropylene (Polyoxpropylcne) Glycols. C. Boyd Shaffer, Ph.D. (Physiol.); Charles P, Carpenter, Ph.D.(Med. S c.); Frances H. Critchfidd, M .S .; John H . N a lr III, M.S., ana Frederick R . Franks, M .D,, Pittsburgh 448 Aiding the Cardiac P atient In Industry. Edw ard M. Kline, M.D., Nela Park, O ev elan d .. . 454 Air Flow Measurements on Human Subject* W ith and W ithout Respiratory Resistance at Several W ork Rates, Leslie Silverman. S cX .(Indust Hyg.) j George L ee'T h eo d o re PlotWn, A .B .; Leonore Amory Sawyers, A.B., and Anne R . Yancey, A.B., B o sto n ...- 461 Chronic Toxicity of the Mcthylpolysiloxane "D C Antlioam* A " in Dogs. George P . Child, Ph.D., M X .; H enry Osmond Paquin Jr., M.D,, and W illiam B. Deichmann, Ph.D.. Albany, N . Y .......................................... ...................................................................................... 479 Activities of State and Local Agencies in Industrial Health. Victoria M, Trasko, Washington, D. C ...................................................................................................................... 483 Cadmium Poisoning. Lawrence H . Cotter, M.D., and B. H . Cotter, MX)., New Y ork.......... 495 Investigation o f Small, A irborne Charged Particles by an Electrical Method. J. H . Darnel, Sc.D.(Physfcs), and F . S. Brackett, P b X .(P bysics), Bethesda, Md........... 505 Abstracts from C urrent L iterature..................... ......................................................... .................... 520 News and C o m m e n t........................................................................... ............................................ 541 JU N E 1951. N U M B ER 6 STMPOSKIM ON THE TREATMENT or CHRONIC BBYlinW fOISOMING WITH ACTS ANS CORTISONE . . Chronic Pulmonary Interstitial Granulomatosis: Preliminary Report on Two Patients Treated w ith A C T H . Joseph M. De Nardi, M X ., Lorain, O hio......................... ........... 543 Case of Chronic Beryllium Poisoning from Atomic Energy Development, Robert J . Hasterlik; M.D., Chicago........... .............................................................. 547 Five Cases from the Fluorescent Lamp Industry; Treatment of Chronic Beryllium Poison ing with A C T H and Cortisone. Edward M. Kline, M .P .; Scott R. JnWey, M .D , and W hiter H . Pritchard, M X * Cleveland.................................................................................... 549 Chronic Berylliosis in the Neon Sign Industry. 0 . A . Sander, M .D , M ilw aukee,............ 565 Spontaneous Remission of Chronic Beryllium Poisoning from Fluorescent Lamp Manufac turing; R eport of a Case. John W . Cass Jr-, M X ,, Brookline, Mass........................... 569 ' JU N E --Continued PAGE Chronic Beryllium Poisoning, of Long Duration from Fluorescent Lamp M anufacturing; R ep o rt of a Case. George K . Fenn, MJD, Beverly. M ass.............................................. 571 Beryllium Disease "from the Ceramic Industry: Report of a Case. Preston W . Reynolds. M .D , Schenectady, N - Y . . . . ................... ...................................................................................575 Volvmb 3 Metabolic Study of a O we of Chronic Beryllium Poisoning Treated with A C T H . H arriet L- Hardy, M .D .; Frederic C. Bartter, M B , Boston, and Abraham B. Jaffln, M.D., Jersey City, N . J . .......................................................................................................................... 579 Choice of Drugs and Dosage. Howard S. V an Ordstrand, Cleveland.......... ................. . 583 Recognition and P reten tio n of the Complications of A C T H and Cortisone Therapy. Thomas F . Frawley, M D ., Boston ...................................................... .................................................. 587 Information Gained in Pretherapy'and Post-Therapy Pulmonary Function Studies. John M cdem ent, M D , N ew Y ork........ ............................................................................................5 Pulm onary Function in Patients w ith Pulmonary Disease T reated w ith A C T H - , B< G. F erris J r , MJD.; J . & Affddt, M .D.; H . A. Kriete, A JB, and J . L . WWttcnberger, M J > , B o sh * . . . . ............................................... ....................................................................... 603 Interpretation of Rsult of A CTH and Cortisone Therapy In Chronic Beryllium Poison- inert D ata Obtained by Pretherapy and Post-Therapy Studies of Pulm onary Function. G eorge W . W right, M ,D , Trudeau, N . Y ................................................................... .......... 617 Minimum Observations Necessary to Advance Knowledge of the Action of A C T H and Cortisone. Anne Forties, M J ) , Boston....................................... .............. .......... .. 622 Current Research Problems Concerning Pulmonary Granulomatosis in Beryllium W orkera. Friedrich Klemperer, M .D , Trudeau, N . Y ......... ............................... .........................625 General Discussion on the Treatment of Chronic Beryllium Poisoning w ith A C T H and Cortisone ......................................................................................................................................... 629 A5BES A long "uttburnat number ol composed because tl units of r microns 1 stiller ihi yam and H ealth Hazards in the Production and Handling of Vanadium Pentoxide. Sven-G5sta Then A SjSbcrg, M .D , Eskilstuna, Sweden............................................ ........... ...................................631 to the sei N ews and C o m p i e u t - ........................... .............. .........................- .......................... .. 647 common Book Reviews ................ ..................................................................................................... *............... 646 A m pl croridolif Serp< The 2H tO ,w of die T am osite Chiysot composr fibers w massive is trave barely ] across 1 "Froi Thh th an tw was nea report* to time of the A l* M * A l * A B 'C H IV E S OP Industrial Hygiene and Occnpational Medicine E D IT O R IA L BOARD PHILIP DMNHER, Chief Editor 55 S&attcS Street) Boston J5 THEODORE F , BATCH, PttU bnrgh FENN E, POOLS, Glendflle, CUf. ROBERT A. KEHOB, C incinnati FRANK FRlNCI, Denker FRANK A . PATTY, B e tr itt WILLIAM A. SWYER. RocResUr, N. Y. JAMES H. STERNER, Rochetrttr. N, Y. RICHARD 3. PLHNKEJT, HA., ChlOfigo, Monatftng E ditor Volvub 4 1951 PUBLISHERS AMERICA MEDICAL ASSOCIATION CHICAGO 10, tVL. CONTENTS OF VOtUME 4 JU L Y 1951. N U M B E R 1 PAGE A Method of Obtaining Reproducible Breath Radon Samples. John H . Harley, M .S.; Evelyn Jetter, and M crril Elsenbud, New Y ork........ ....................................................... I Industrial and Forensic Applications of Electroencephalography. Joseph L. Fetterman, M JX , and V ictor M , Victoroff, M.D., Cleveland................................................................ 10 Control of D usts by W ater Mists. Kenneth W , Nelson, B ^ d , S alt Lake Q ty .................. 25 Symptomatic Treatment of the'C om m on Cold. Ronald Forbes Buchan, M .D , C M .; Alfred E . Gras, M.D., and F ran k H . David. A .B , A J3 A , Newark, N . J ................... 32 Arsine*. Electrocardiographic Changes Produced in Acute H um an Poisoning. C arl J. Joscphson, M .D .; Sherman S. Pinto, M.D., Denver, and Samuel J. Petrondla, M.D., E ast Chicago, I n d ......................................................................................................................... 43 Toxicity of Carbon Monoxide and Hydrogen Cyanide Gas Mixtures *. A Prelim inary Report. R. H . Moss, C, F . Jackson, and J. Seiberlich, Durham, N . H .......................... ............ . 53 Persistence of Beryllium Oxide in Lungs A fter Inhalation of Dust- F ran k R . Dutra, M i l . ; Edward J. Largent, A .B .; Jacob Cholak, C h ,; Donald M. Hubbard, Ch-E., and James L, Roth, Cincinnati................................................................ ....................................... 65 Study of Eye Irritation Caused by Los Angeles Smog. Richard D . Cadle, Fb.D . (C hcm .), and Paul L . Magill, B .S , Stanford, CalK .........................................; . . . ............................ 24 New Instruments and Technics: Determination of Naphthalene in A ir. M . Cllain Robbins, B.S., Los Alamos, N . M .... 85 Abstracts from C urrent Literature....................................................................... ......................... 88 News and C o m m e n t.............................................................. .............................. ........................ 100 Book Reviews..................................................... 102 A U G U ST 1951. N U M B E R 2 Size of Cuttings Produced by Pneumatic D rilling w ith Different K inds of Detachable Bits. Carlton e . Brown, C h E , Sc,D. (In d u st Hygiene), Frederick, M d ......................103 Range-Finding Toxicity D ata; List IV . H enry F. Smyth JrH F E D .; Charles F. Carpenter, P h D , and Carrol S. Weil, M A , Pittsburgh........................................................................ 119 Epidemiology of Beryllium Intoxication. James H . Sterner, MJX, and M crril Eiseftbud, New Y a r ik .,.................................................................................................................................. 123 Organic Pesticides--New H ealth Hazards. Justus C. W ard, M .S , Washington, D . C . . . . . . 152 Generation of Phosgene During Operation of Trichloroethylene Dcgreaser- Louis W . Spolyar, M .P .; R . N. H arger, P h .D .; J . F . Keppler, Ch.E., and H . E . Bumsted, C h X , Indianapolis................................... .1 5 6 Special R ep o rt; Research on H ealth Education in Industry.............................................................................. 161 Hi >v CONTENTS OF VOLUME 4 AUG UST--Continued Abstrete from Curren Literalure. New and C o m m en t..................... <. Book Reviews..................................... SE P T E M B E R 19S1, N U M B E R 3 Methyl Bromide Fumigation and Control In the Date-Packing Industry. Fred R. Ingram, M .S., Berkeley, C alif................................................................................................. .............. ly j" Arsenic and Cancer: O bsem tions in the Metallurgical Industry. Leonid S, Snegireff, M JD , and Olive M . Lombard, S.M., Boston...................................................... ................... 199; Effect o f Bituminous Coal Dust and Smoke on the Lungs--Animal Experim ents; 1. Effects on Susceptibility to Pneumonia. Frederick J . Vintinner, Sc.D , Concord, N . H-, and A nna M . Baetjer, Sc.D , Baltimore..................... ................................ .................................. j Effect of Aluminum Dust on Susceptibility to Lobar Pneumonia--Animal Experiments. Frederick J, Vintinner, Sc.D , Concord, N . H ....................... ................. ............ i Etiologlc Factors in BroncMogenic Carcinoma, with Spedal Reference to Industrial E xposures: Report of Eight Hundred Fifty-Seven Proved Cases. E rnest L. Wynder, M.D., New York, and Evarts A. Graham, M JD , S t L o n i s . . . . . . ........................... . 221/ Evaluation and Significance of Physical Fitness for Moderate W o rk : A Study of Patients w ith Cardiovascular or Pulmonary Diseases. Robert A. Bruce, M.D,, Seattle; Frank W . Lovejoy J r , M .D .; Paul N. G. Yu, MJD., and Marion E. McDowell, M.D, Rochester, N . Y ..................................................... .............................................................. i Beryllium Excretion in Humans. F. W , Klemperer. M.D.; A. P . Martin, and J. Van Riper, Saranac Lake, N . Y . . . . . . . ............................. ....................................................... i Clinical Observations on the Toxicology of Boron Hydrides. H . M. Roaendnat, M-D, Schenectady, N . Y .................. ................................................................................. ............. - .5 Toxicology of Two Butoxypolypropylene Glycol Fly Repellents. Charles P . Carpenter, P h ,D .; Frances H . Critchfield, M .S.; John H . N air I I I , M .S , and C. Boyd Shaffer, P h JD , Pittsburgh............... ........................................................................................ . 1 Coal W orkers' Pneumoconiosis: Pathological and Etiological Considerations. A. G, Heppleston, M i . , M .R.C.P, Cardiff, W ales................... ................................................. * A bstracts from Current Literature.............. .................................................................................. ^ N ews and C om m ent......................................................................................................................... 20$; O CTO BER 1951. N U M B E R 4 SYMPOSIUM OH A CANCER CONTROL PROGRAM FOR HIGH-BOILING CATALYTICAUY CRACKED OILS Teamwork in Control of Occupational Diseases: An Introductory Statement Robert Collier Page, M -D , New Y ork....................................................................... ......................... 3 Experimental Analysis of the Carcinogenic Activity of Certain Petroleum Products. William B. Smith, MJD.', Douglas A. Sunderland, M .D , and Kanematsu Sugiura, Sc.D, .. New Y ork......................... .............................................. ............. ............................................... 299 - Properties of High-Boiling Petroleum P roducts: Physical and Chemical Properties os Related to Carcinogenic Activity. H . G. M. Fischer, E E .; William Priestley J r , M.S.; L. T . Eby, P h .D .; G. G. Wanless, B .S c, and John Rehner J r , PhJD , Linden, N- J - CONTENTS OF VOLUME 4 v ) OCTOBER--Comtimti _.J PAOB Canttr-Cbntrol Program fo rH Ig h -B o iik g Catalytically Cracked Oils. J. P. H olt, M.D., p|iJ), j N , V. Hendricks, B.E., C h.E.; R. E, Eckardt, M D , Ph.D .; C L, Stanton, JJ.S., and R . C. Page, M .D,, N ew Y o r k . . . ........................................................................ . 325 opertiei of High-Boiling Petroleum Products ^Quantitative Analysis of Tumor-Response B ata Obtained from the Application of Refinery Products to the Skin of Mice. F . H . Blending, M .S.; W . H . K ing Jr., B.S.; W illiam Priestley Jr., M .S, and John Rehncr Jr., P h D.. Linden, N . J .................................................................................................................. 335 f o r Deposition and Retention of Inhaled Insoluble Particulates. H . E. Stoldnger, Ph.D., Cincinnati; L. T . Steadman, P h .D .; H . B. W ilson: G. , Sylvester; S. Dziuba, B.S., and C W . LaBelIeAM A , Rochester, N . Y ... . . -- ........................................................... 346 gdngement of Dust from A ir Jets. C N . Davies, D .S c, F .Inst.P .; M ary Aylward, and Dorothy Lcaccy, London. E ngland............................................................................................ 354 *rtii Reports: Threshold Lim it Values for 1951 Adopted a t the Meeting of the American Conference of Governmental Industrial H ygienists in Atlantic City, N . J , in A pril, 1951.......... 398 tracts from C urrent L i t e r a t u r e . . . . . . . . ..................................................................................401 sws and C o m m e n t................................................................................ ........................................ 414 Mk Reviews........................................................................ ................................................................ 415 N O V E M B E R 1951. N U M B E R 5 eatment of Cyanide Poisoning in Industry. J . H . Wolfsic. M .D- Linden, N . J . , ................417 tof" nd Labor-Saving Devices in the Industrial Dispensary. Jean Spencer Felton, M.D,, f' JRidga, T ens. - IV , Clinical-Record Distribution Box for Physician's O f f ic e ....,..............................426 V. Optical Dispensing U n it................. ....................................................................................................................................................................................432 V L M ultipurpose Central Clerical Desk for Treatment Room............................... .. 437 -Ray Diffraction Study of Sputum in Silicosis. F ran k Meyer, M .S c, and Saul Solomon, ' M .D , New Y o rk ............................................. ......................... .............................. ...................443 w ncteristks of the Suction Soap Film M eter: The Suctionometer--a New Low-Velocity Measuring Device. B ernard D. Bloomfield, S.M., and Leslie Silverman, ScJD, B o sto n ., 446 .ellndnary Observations on Toxicity of. Elemental Selenium. Robert H . H all. P h J ) .; Sidney L askin, A .B .; Paul F rank, A R .; Elliott A. Maynard, Ph.D., and H arold C Hodge, P h.D ., Rochester, N-Y............................................................................................. . 458 W ttx of Rodents to Repeated Inhalation of Vapors o f Tetraethyl OrthoeiKcate. U . C Poizanl, M .S , and C. P . Carpenter, P h D ., Pittsburgh........................................................ 455 *Por Toxicity o f Trichloroethylene Determined by Experiments on Laboratory Animats. E . M. Adams, P h D .: H . C Spencer, PhJD,; V . K . Rowe, M .S.; D. D. McColHster. B R , and D . D . Irish, P h .D , Midland, Mich.......................................................................... 459 por Toxkity of Ethylene Dichloride Determined by Experiments on Laboratory Animals. H . C Spencer, Ph.D.S V . K . Rowe, M S .: E. M. Adams, Fh.D .j D. D. McColileter, B R , and D . D . Irish , P h .D , Midland, Mich,........................................................................482 1* Toxicity o f an Imidaaolin (or Glyoxalidinej. Fungicide, Charles F . Carpenter, PhJD .; Carrol S. W ell. U A , and H enry F - Smyth J r , P h .D , Pittsburgh......................... . 494 vi CONTENTS OF VOLUME 4 KOVRmW -Cmtimtd FACE A bstracts from C urrent lite r a tu re , r .......................................................................................... 504 N ews and Comment.................................................. ......................................................................... 518 . D EC E M B ER 1951. N U M B E R 6 Benzidine (4,4'-Diaminobiphcnyl) and Substituted Benzidines: A Microchemical Screening Technic for Estim ating Level* of Industrial Exposure from U rine and A ir Samples. J. M , Glassman, Fh.D ., Philadelphia, and J. W ister Meigs, M.D., N ew H aven, Conn..-. 519 A Study of Exposure to Benzidine and Substituted Benzidines in a Chemical P la n t; A P re liminary R eport J. W ister Meigs, M .D .; Robert M. Brown, M .P3L, and Lonis J. S d a iia i, PhJD., New Haven, C o n n . . . . , . . , ............................................................................ 533 Rehabilitation of Persons w ith Pulmonary D ust Disease. 0 . A . Sander, M J X M ilw aukee.. 541 Flatinosis'- A Five-Year Study of the Effects of Soluble Platinum Salts on Employees in a P latinum Laboratory and Refinery. A , Eaton Roberts, M .D , Malvern, P a ........... ........... S49 Aldrin Poisoning in M an t Report of a Case, Lieutenant Eugene J . Spiotta, Medical Corps, U nited States A rm y........................................... - ......................... .........................*.................560 T he Chylomicron Count as an Indicator of Phosphorus Poisoning t A Study Utilizing Experimental Animals. R . B. L, Fleming, B.S., M.S,, and 6 . H . Collings Jr., M ,D , M .P 4 L , W ilson Dam (Sheffield P.O .) A l a . . . . . . . . . . ........................................................ 567 Toxicity of Di-(Acetyl Cyanide). Joseph F . Treon, Ph,D .; Frank R . Dutra, M J ) , and John Cappel, B.S., Cincinnati.............. ........................................................... ....................... 573 Absorption and Excretion of Inhaled Fluorides. Gilbcart H . Collings J r,, M.D., M .P .H .; Richard B. L. Fleming, M .S , and Roy May, M .S , W ilson Dam (Sheffield P . 0 . ) , Ala. 585 Occupational Diseases of Dentist*. F ran k J. Orland, D.D.S., Ph.D, (B a c t), Chicago.......... 591 T he Instituto of Occupational H ealth in Helsinki. Leo N oro, M J)., Helsinki, F in lan d ......... 597 Abstract* from C urrent L iterature.................................................................................................602 News and Comment......................... ................................................................................... 618 Book Review*. 621 VoHJMS 4 A i IT IS WIDE individuals accumulates ir based on data occurring amo bone as distitu most of which The radio mate the radi A direct c of gamnu ra RaC). The of tolerance following thi Radium to interpret with conditi The am exhaled bre radium con to indicate From tl Y ork Opera' Present Atiantic CSr 4 1. Hand 19, Z Erar Radium, J . 3. M ar and Hahdli 4, He* the Hmnar of Radium 102.1947. A. M. A. A B C H I V E S OF Industrial Hygiene and Occupational Medicine E D IT O R IA L BOARD PHILIP DRINKER, C hief E ditor SS S hatfoek Street, Boston IS THEODORB F . HATCH, Pittsburgh OSCAR A . SANDER, M ilw aukee PENN B , POOLE, G lendale, C alif. WILLIAM A . SAWYER, R ochester, N . Y . FRANK PR1NCI, C incinnati HERBERT E. STOKINGER, C incinnati JAMES 1, STERNER, R ochester, N . Y. RICHARD J . PLUNKETT, M-D-. Chicago, Managing E ditor V olume 5 1952 P U B L ISH E R S AMERICAN MEDICAL ASSOCIATION CHICAGO 10, ILL. CONTENTS OF VOLUME 5 ' JA N U A R Y 19$Z, N U M B ER 1 PAGE Treatment of Chronic Pulm onag Disease w ithlntcrm itteut Positive Pressure Breathing: 1 JoSffT * tE ralu atlo n by Objective Physiological Measurements. H urley L. Motley, M.D.. and M.D., Philadelphia............................................................................ 1 Tetiyl Toxicity: A Summary oi Ten Years' Experience. Burton B. Bergman, M.D., Newark, N . J ................. ...................................................................................... ...................... 10 Exhaust Ventilation for Machine Tools Used on M aterials of H igh Toxicity. H - F . Schulte, M.S.; E . C. H yatt, B .S , and F . S. Smith J r , B .S , Los Alamos, N . M ex........ . ........... 21 Further Investigations on Chronic Cadmium Poisoning: A Study on Rabbits w ith`Radioactive Cadmium, Lars Friberg, M D ,, Stockholm, Sweden................................................... 30 Plastics: Their Dermatological and Chemical Aspects. George . Morris, M D , B oston......................... ............................................................................... .......... ......... 37 Effects of Dimethyl and Diethyl Paratdtrw hcnyl Thiophosptate on Experimmial Animals. W illiam B. Deichmann, P hD .} W ilfiam Pugliese, A.B., and James Cassidy, B .S , Albany, N, Y .......................................................... ..............,................................................... 44 Physiological Response of Experimental Animals to the Vapor of 2-N itropropw e. Joseph F, Treon, P h D , and F ran k R. Dntra, M.D., Cincinnati......................... ....................... 52 The Spiral Sampler--A N ew Tool for Studying Particulate M atter. Charles D , Yaffe, M .S.; Andrew D. Hosey, B .S , and John T . Chambers J r , B.S., Cincinnati................. 62 Management of the Older Employee with Medical Problems. Rufus Baker Crain, M.D., M .P.H ., Rochester, N . V . ......................................................................................................... 71 Abstracts from Current Literature................................................................................................ 82 News and Comment........................................ .................................................................................. 95 Book Reviews................................. ............................................................................... .................. 96 FEBR U A R Y 1952, N UM BER 2 CONFERENCE ON PROBLEMS OF NOISE IN INDUSTRY Sound and Its Measurement Leo L . Baranek, D.Sc-, Cambridge, Mass................................. 97 Industrial Plant Environmental Study. Charles R. Williams. F h .D , Boston......................... 109 Estimating Percentage Loss of Hearing. H oward A. Carter, M .E , Chicago......................... 113 Noise Safety Criteria, K arl D. K ryter, P h D , Washington, D . C , . ................................. . . .. 1,17 E ar Lesions Caused by Acoustic Trauma. Stacy R. Guild, F h -D , Baltimore......................... 121 Clinical Aspects of the Problems of Noise m Industry. H ow ard F . House, M D , Los Angeles ........................................... .......................................................................................... 124 Noise and Noise Reduction: Control.,Methods Applied. W entworth D. Boynton, B.Eng., ' Baltimore ...................................... ; ......... ............................................................................... 129 The Legal Aspects of Occupational Deafness. Noel S. Symons, B uffalo............................... J38 Medical and Legal Aspects of Noise in Industry: A Discussion of Papers Presented. Gordon D. Hoople, M D , Syracuse, N .Y .................... ....................................................... .............157 Summary of Conference on Problems of Noise In Industry. W alter A . Kosenblith, Ing.Rad-, Cambridge, M a s s . . . . . . . . . . . . .......................................................................... . j HI V V INDUSTRIAL HYGIENE AND OCCUPATIONAL MEDICINE . FEBRU ARY --Ctm/ftWid PAdfi Abstracts from Current L iterature......................... ......................................... .............................. 164 News and Comment........................................................ ..................................................................181 Book Reviews......... *...................... ................................................................. ............................. 183 M ARCH 1952, N UM BER 3 PROCEEDINGS OF THE CANCER PREVENTION COMMITTEE Note and Index of Proceedings........................................... ...........................................................185 Purpose and Program of the Cancer Prevention Committee. William E. Smith. M.D., New Y o rk ..................................... ............................................................................................. 187 T rends In Cancer Mortality. E, C urler Hammond, ScD ., New Y ork................... .......... . 190 Lung Cancer in the Chromate Industry. Frederick Gregorius, M.D., New Y ork..................196 U se of Life Insurance Company Records for Cancer Studies. E . A. Lew, A.M-, F.S.A., New Y ork..................... . . . . . . . . . .............................................................................................T 198 Occupational Cancer H asards in American Industries. W . C. H neper, M.D., Betbesda, Md. 294 L ung Cancer with Special Reference to Experimental Aspects. William E. Smith, M.D., New Y o rk .......................................................................................................................... .. 209 Studies on Lung Cancer in Relation to Smoking. Ernest L. Wynder, MJ., New Y o rk ........218 Industrial Exposure to Chromates in New York State. H erbert S. Dankman, New Y o rk .. 228 Use of the Cytologic Method in Industrial Medicine, with Special Reference to Tumors of the L ung and the Bladder. H enry A. Cromwell, M.D., and George N. Papanicolaou, M.D,, New Y ork.............................................. .......... ............................ ........ , ...................... 232 Bladder. Lesions from Aromatic Amines : Statistical Considerations and Prevention. Mario Barsotti and Enrico C. vigliani, Milan, Italy. Translated by Louis J. Sciarini, Ph.D., New Haven, C o n n ............................ ............................................................................ . 234 Survey of Some Current British and European Studies of Occupational Tumor Problems. W illiam E . Smith, M,D., New Y o r k . . . . . . . . . ................................................... .................242 Chemical Causes of Occupational Cancers: Aromatic Amines Acting on the Bladder. Ren Truhaut, Paris, France. Translated by Rosamond de St, Phalle, New Y o rk ....................264 I W orkm en's Compensation Insurance as a Source of Data on Tumors In Relation to Occu pation. R. N . Gray, M.D., H artford, C o n n . . . . . . . . ........................................................... 274 I1 T he Program of the New York State Occupational Cancer Committee. May R. Mayers. M .D , New Y ork..................................................... ................. .................... . 279 The New Jersey Occupational Cancer Survey. Edwin D. Merrill, M .D , Milford, N. J ___ 284 Comments On Occupational Cancer Surveys in the United States. W . C Huepcr. M D Betbesda, M d....................... ....................................................................................................7 288 A bstracts from Current L iterature....................... ............................................ ........................... 290 News and Comment..................................................................................................., ................... Book Reviews..................................................... .......................................................................... 305 A P R IL 1952. N U M B ER 4 Studies on the Toxicity and Skin Effects of Compounds Used in the Rubber and Plastics industries ; L Accelerators, Activators, and Antioxidants. F. S. Mallette, Akron, Ohio, and E . von Haam, M.D., Columbus, Ohio............................................................" .........' 31J T oxW ty of Sulhiric Acld M k t to Guinea Pigs. M ary O. Amdur, Ph.D .; Ruben Z. Schulz. M .D , and Philip Drinker, Ch.lL, Sc.D., Boston......................................................... . .7 318 Hazards from Thernr P h D .; J<*n D. i ville, V a ...,.< * - Man, Submarines, am London, Com... Patissier's Oceup&tiot Disinfcetive Action Spores. Robert ' Dohrman H . By Influenza-Virus Vac* The Physician ia Im Some Colloidal Prop Concentrations of P i Ch.Et S e D .,1 Special Article: Prophylactic As Abstracts from Cm Books ..................... Evaluating Effects Air Force.-- . Audiometric Data I M.D,, Chicago An Objective Met! M.S., Chicago Progress Report w. Hearing. Hon A Spot Test for Etherington, E Pulmonary Tako* William E. Js Jet Impacto n for Fh-D* and J. Problem of. Astbir A Comparison o f ' Lewis H . Bro cation Unit, , Bellevue Hos Abstracts from C News nnd Comm Books ................. CONTENTS OF VOLUME 5 ' * ATFLL--Continued _ . rACE ,, , <riwn T hennal Decomposition of Motor-Insulaling Materials. Julios Semlroy Jr., H* 1 & 7 o l J ^ W nS j Z * . B e th e a , M d, and Grover C Pitts, P h D , Charlottes- ^ vine, V a............................. .....................: .................................................................................... Man, Submarines, and C arton Dioxide. Commander H arry J. Alvis (M C), U S. N-, Hew ^ London, Conn............................... ....................................................... ................................. Patissier's Occupational Diseases. F. Ronehese, M.D., Providence, R. 1................................. 347 nsrinfcetlve Action o Methyl Bromide, Methanol, and Hydrogen Bromide 0 Anthrax Spores Robert W . Kolb, M .S.; Roy Schneiter, Ph-D.; E arl P. F % d , M.S., and Dohrman H . Byers, M .S , Cincinnati.........................................................................................384 Influenza-Virus Vaccination in Industry. C. F . Yeager, M D ., Bridgeport, Conn............365 t h e Physician in Industry and the "Alcoholic" W orker. Leo J . W ade, M D ., New Y o rk .. 363 Some Colloidal Properties of In ert Dusts. R. F . Hounam, B-Sc., W antage, Berks, England 37S Concentrations of Particulates Found in A ir. Melvin W . F irst, Sc.D,, and Philip Drinker, C h i , S c D , Boston......................................................................................... 387 Special A rticle; , Prophylactic Aspects of the Mental Health of the Physically Disabled............................. 389 Abstracts from Current L iterature....................................................................................................395 Books ............ 4 ,3 MAY 1952. N U M B ER S Evaluating Effects of Industrial Noise on Man. M ajor H orace 0 . Parrack, United States A ir Force........... .......... ................................................................................................................ 415 Audiometric D ata Following Exposure to Low-Frequency-Centered Noise. E. J. Sehowalter, M .D , Chicago................................................................................................................. .............430 An Objective Method of Classifying Industrial Noise Environments. Ralph M. McGrath, M .S, C h icag o ...................................................................................................................... . 4& Progress Report of Committee: Revision of Procedure for Evaluating Percentage Loss of Hearing. Howard A . Carter, M.E,, Chicago..................................................................... 445 A Spot T est for Estimating Concentrations of Boron Hydride Vapors in A ir. T . L. Ethcrington, B.S., C h.E, and L. V . McCarty, P h D , Schenectady, N . Y ..................... 447 Pulmonary T akosis with Involvement of the Stomach and the H e a rt: Report of a Case. William E . Jaques, M.D., and K urt Benlrschkc, M D , Boston........................................ 451 Je t lmpactors for Determining the Partide-Sire Distributions of Aerosols. W . E. Rsnz. P h.D , and J . B, Wong, M .S , Urijana, III........ .......................................... ...................... 464 Problem of Asthma in Industry. W . C Spain, M .D , and V- J . Fontana, M .D , New Y ork 478 A Comparison of W orking and Nonworldng Cardiac Patients. Leonard J . Goldwater, M .D .; Lewis H . Bronstein, M .D , Beatrice Kresky, M D , and the Staff of the W ork Classifi cation Unit, Adult Cardiac Dinlc, Third (N tw Y ork University) Medical Division, Bellevue Hospital, New Y ork..................... *................................ ...................................... . 485 Abstracts from Current L iteratu re............................................ ............................... ...................490 News and Comment.................................................................... ............................... .514 Books ............. ........................ ......................................................... ....................................... 516 vl in d u str ia l h yg iene a n o occupational m ed icine JU N E 1952. N U M B E R 6 PAOS A Rational Approach to Air-Pollution Legislation. George E. Best, B altim ore.................517 Deposition oi Siliceous Dust in the Lungs of the Inhabitants of the Saharan Regions. Quest for a Suspected Industrial Carcinogen. Carrol S. Weil, M A ; H enry F . Smyth Jr., P h D ., Pittsburgh, and Thomas W /N a le , M.D., New Y ork............................................... S35 Organization and Operation of a Study of A ir Pollution in Relation to Experimental Carcinogenesis. Paul Kotin. M .D , Los Angeles.................................................................... 548 Clinical Pulmonary Physiology; I. Evaluation of Function Impairment and Now Develop ments in Therapy of Chronic Pulmonary Disease, Hurley L . Motley, M D ., Philadelphia 554 Vapor Toxicity of Tetrachloroethylene for Laboratory Animals and Human Subjects. V. K . Rowe. M .S.; D. D, McColllster, B .S.: H . C. Spencer, P h D ,; & M. Adams, P h D , and D. D- Irish, P h D , Midland, Mich.....................................................................566 The Environmental Health Program of the United States Public Health Service. Mark D . Hollis, C.E., Washington, D. C. 580 O b ituaries: S ir Leonard H ill.................... 587 Abstracts from Current Literature 589 News and Comment....................... 605 \ pj:' A. M . A . ); A It C H I V B S O F Industrial Hygiene (kenpationa Medicine ED ITO RIA L BOARD ' RH ItlF JDtttKft. C hief Editor . SS Shattuck Street, Boston IS THEODORE F . HATCH, Pttbnr(|h OSCAR A . SANDER, M ilwaukee FENN B. POOLE, G lendale, C alif. . WILUAM A . SAWYER, R ochester, N . Y. FRANK FMNCJ, C incinnati HERBERT E. STOK1KGER, C incinnati JAMES H. STERNER, Rochester, N . Y. Volume 6 1952 ru n u sh er s AMERICAN MEDICAL ASSOCIATION CHICAGO 1, ILL. V , .--I1K*, - , y !> .1 vl'/ l 1* li. tl V V Ifcjr Wt\ &1 &w <e Si. I m cu t*"! ' l ' \ ' ** ' 1 v . * '* .'vi,, v . i ; i 'v i - v ' ' ' ' iv INDUSTRIAL HYGIENE AND OCCUPATIONAL MEM A U G U S T ---CflKntt/rf ;'i| Fatal Exposure to Methylene Chloride Vapor. Samuel Moskowita, Ch.E.. F York) and H arry Shapiro, M.D., Now Rochelle, N . Y ......................... Instruments for Measuring Secondary Radiation, W illard W . Van Allen, B.Sc.fl TM ............................. ......................................................................................... ; - - - k Acrylonitrile: Spectrophotometric Determination, Acute Toxicity, and M eehT Action. Heinrich Bricger, M .D.; Fredric Rieders, Ph.D,, and W illiam AS A.B., P h ilad elp h ia................. ..................................... ..................... H ealth Program a t a Medical Center, J. B. Feldman, M .D , and M. D. Kass Philadelphia ............................................................................ ................ Industrial Medicine and the.G roup Clinic--a Mutually Advantageous Relatonship Spencer Felton, M.D., Oak Ridge, T e n n ..,........ ......................... ........................ Toxicity of Ethylene Dihromide Determined on Experimental Animals.' V . K . R ow | H . C. Spencer, Ph.D .; D. P . McCollister, B .S.; R. L. Hollingsworth, M.S., t u r n - A dana, P h .D , Midland, Mich.............................. ..................................................... O , Anticholinesterase Activity of Tributyl Phosphate. Jean Captain Sabine, M.D., and r N ew ton Hayes, P h -D , Los Alarm s, N . . ..................... .............................................^ Special Reports: T hreshold Limit Values for 19S2............................................ . ............................ . -- A bstracts from Current L i t e r a t u r e ...,,................ .................................... . News and Comment........................................................................ ................ S E P T E M B E R 1952. N U M B E R 3 A ir Pollution by Hydrogen Sulfide in P o ra Rica, M exico: A n Evaluation of the Indd of New. 24, 1950. Louis C, McCabe, P h D ., and George D. Clayton, W ashington, O, Retention, Distribution, and Elimination of Inhaled Particulates with Particular Reference 1 the Evaluation of Radiologic Risk. M erril Eisenbud, New Y o rk .. . Rapid Analytical Method for Air-Pollution Surveys: The Determination of Total P a rti-. culates and the Rapid Scmlqnantitativc Spectrographic Method of Analysis of the M etallic Constituents in High-Volume Samples. R. G. Keenan, M.S., and D. H . Byers, M. S , Cincinnati............................................................... ........ Studies on the Toxicity and Skin Effects of Compounds Used in the Rubber and Plastics Industries, ' J II , Plasticizers. F. S. Mallettc, P h D , Akron, Ohio, and E . von Haem, M .D , `l Columbus, Ohio ....................................................................................................................... 231-. n i . Carcinogenicity of Carbon Black E xtracts, E . von Haam, M .D , Columbus, Ohio, and F . S. Mallotte, P h D , Akron, O hio.............................................................................. 2 # .'>3 Eye H ealth Evaluation and Maintenance. ' A . D . Ruedemann, M .D , D etroit............................................................................................ 243 A rth u r K . Peterson, M .D , Chicago..................... ............................................. .......... . 248 Parathion Exposure and Cholinesterase Response of Quebec Apple Growers. Kingsley Kay. M ,A , P h D .j L . Montanan, B A ; J . P . WtetBeh, B.Sc,; T . Doherty. Ottawa, Canada; J . P ar, M.5c., and C Raclcot, Montreal, C an ad a................................. 252 Pharmacological Studies of Radiogermanium (GE*1) . Commander H . C. Dudley (M SC), U . S. N , and lieutenant (Jg) E . J . W allace (M SC ), U- S, N . R ,......................... 263 A Rapid Micromethod for Electrometric Determination of Red Cell Cholinesterase Activity in W hole Blood. W . E . MacDonald J r , Jacksonville, F la .; C, B- Pollard, and A. H . Gropp, Gainesville, F la.......................................................... ................................................. 2/1 . A bstracts from Current L iteratu re........... ......................................... .............. ........................... 2 ^ News and Comment ............................................................ ............... ...................- ........................ ^ Books .....................................................................................................................................................292 R ubina** Studies on Fat* . j se n . * Ttmporary <3? John B. u i Etiology mcd. H of* Acute 9 * ^ 5 Meigs. M . Chronic O ral ` W ilson Abstracts fn News a l Femes and 1 Sven F* Carbon Mo* Alvls ( Industrial I MD, Counting o Occurrene S. Lie Carbon T Relative ' Chid Be i CONTENTS OF VOLUME 6 v O C T O B E R 1932, N U M B ER 4 ' PAGE Submarine Rescue and Escape. Commander H a rry J, Alvis (M C), U . S. N ................. ,.2 9 3 u-urinn of Sulfuric A d d Mist by Human Subjects. M ary O. Amdur, Ph.D .; Leslie ^ S ilv e r m a n , SeD-, and Philip Drink-, Ch.E., Sc.D., Boston................................................ 305 ,i*. M a Five-Year Investigation of A ir Pollution in Cincinnati. J, Cholak, Ch,E-; ^ L j S e h a C B .S E ., and R. F . H o ff , B.S., Cincinnati.................................................... 314 e..Ain an F ate of Parathion in Rabbits, U sing Radioactive Isotope Techniques- J. A. S j W , B &. ChJE.; W . F . Durham, PH.D., and G. W , Pearce, Ph.D., Savannah, Ga. 326 Temnorarv Changes hi Acuity of the Human E a r Following Exposure to Intense Noise. T |S m B . Gallagher, M.A., and John K Goodwin, Ph.D,, Toronto, Canada.......... . 332 fftklottr of Corundum Smelter's Lung <Bauxite W orker's Lnng, Shaver's Disease), D r. ^ ^ m e d . H orst GSrtner, Saarbrucken, S aarland........................................................ - .............. 339 Carbon Monoxide Poisoning: A n Analysis of One H undred Five Cases, J. W ister ^ Meigs, M D , New Haven, C onn, and J. P . W . Hnghes, M .D , Birmingham, England. 344 Chronic Oral Toxicity of Chlordan to Rats. Lester Ingle, P h .D , Urbana, Hi........................ 3S7 Ahsorotion and Excretion of Inhaled Fluorides: F urther Observations. 0. H- Collings Jr., M jV M .P.H -: R. B. L. Fleming, M .S.; Roy May, M.S., and W . 0 . Bfancom, B .S , W ilson Dan (Sheffield. P . 0 ) . A la........................................................................................ 368 Abstracts from Current L iterature................................................................................................374 News and Comment........................................................ ................................................................... 380 N O V E M B E R 1952. N U M B ER 5 Fumes and Gases in A rc W elding, E rik Thrysm, C h.E.; Gideon Gerhardsson, Ch.E., and Sven Forssman, M .D , Stockholm, Sweden...........................................................................381 Carbon Monoxide Toxicity in Submarine O perations: Report of a Case, Commander H . J . Ahris (M C), U . S. N ., and Chief Hospitaleorps Man G W . Tanner (S S ), U. S. N ... 404 Industrial Medicine in Sweden: Recent Experiences and Future Problems. Sven Forssman, M.D., Stockholm,. Sweden........................................................................................................ 407 Counting of D ust Particle by Phase Microscopy. Germain Crossmon, B .S , Rochester, N . Y. 416 Occurrence of Anthrax Bacilli in the Carpet-W ool Industry in the United States. Robert S. Lloyd, M .S , Cincinnati.................................................................... .................................. 421 Carbon Tetrachloride M ixtures in F ire Fighting. H . H . Fawcett, Schenectady, N . Y . ... 435 Relative Toxicity of Lanthanum. Tantalum, and Thorium Compounds in the Developing Chick Embryo. L. J. Mechlin, M .S .; P. B. Pearson, Ph.D.. and G A. Denton, B.S., Beltsville, M d . ........................................................................................................................... 441 Problems Encountered in Field U se c Thomas Autometer. Paul M , Clever, D etroit.......... 445 Obituaries: . Fenn Eugene Poole, M.D......................... ................................................................... ..............450 Abstracts from C urrent L iterature................... ........................................................................ .. 4S2 News and C om m en t...... ..................................... .................................................................... ........... 464 D EC EM B ER 1952. N U M B ER 6 Industrial Health Experiences in Pennsylvania. How We Began the W ork. Charles-Francis Long, M.Dh Philadelphia................... ... 469 The Trade Organization Fosters In-Plant Industrial H ealth: The Williamsport Experience. C E , Noyes, WlUiamaport. P a . . , . . ...................................................... .................................. 472 The Union Health Center Fosters Employee H ealth : The Philadelphia Experience. Joseph A, Langbord, U JD , P h ila d e lp h ia ................................... ....................................................... 474 i ir p5; : u ?| ; '$ 7 ; ' K;, . f ' b 1 i -?ir. r: ' :'.vii.; S'1 ' i: . j *=.. J . |p 1 ^ IW;- V7|-< W .1 6*. 7)1. n'- r k? * **' '.V. II;' ...u'. ' ' * * " *. '4 . . * . * . * *1 ,* ,' tf'i ' )? Vi INDUSTRIAL HYGIENE AND OCCUPATIONAL MEDICINE DECEMBER--Continued T he Pittsburgh Experience in Undergraduate and Graduate Industrial Medical Education^0., T . Lyle Hazlett. M J)^ P ittsburgh........, .............................................. ............7 .7 ^ 7 TM ' The Industrial Medical Association and Medical D irectors' Club in Pittsburgh. Daniel c . 31 Braun, M.D., Pittsburgh.................................. ...................................................................... 77 4 7?^ ^ Ttcbnfaua of Build-Up of Industrial H ealth in a. Single Community. John D. Harley. ` ` M.D., Williamsport, P a ........................................................................................................... , t ^ a The Technique of die Build-Up of an Individual Industrial Medical Practice. Glenn Everts. M D ., Philadelphia,................................................................................................. .............7 .7 :481 Improved Photometric Determination of Carbon Monoxide by M eans of Palladious Chloride. ' . Eugene W . Rice, P h D ., O m aha..................................... ................................................... qg U rinary E xcrrtlw i of Pa'ranitrophenol Following FaratM on Exposure. Jan Lieben, M .D.: \ Rudolph K , Waldman, D r. Chem7 and Leonard Krause, M.S., H artford, C o n n .,,.... 49) (, Coproporphyrinurta. Sherman S. Pinto, M.D., Denver; Christine Einert. M .D ; Wesley J. ' Roberts, Ch.EL, Berkeley, C alif.; Grant S. W inn, P h .D , and K , W . Nelson, B .E i, S alt Lake City.............. . . . . ; ............................................................................................. .777 496, Retention of Air-Borne Particulates m the Homan Lung; III. H . D. LandahL Ph.D .; . T . N . Tracewetl, B.S., and W . H . Lassen, B.S., Chicago................. ................................. 508 ' Bilateral Lenticular Opacities Occurring in a Technician O perating a Microwave Generator. ' Frederic G. Hirsch, MJD.. and John T. Parker, M.D., Albuquerque, N .*M ex.,............512 Death A fter Repeated Exposures to Refrigerant Gases; Report of a Case. Joseph Mendeloff, IL D ^ Fayetteville, N . C . . . . . ............................................................ .................518. Short-Term Intraperitoneal Toxicity Tests. David W . Fassett, M.D., and Robert L. Roudabush, Fh.D., Rochester, N . Y ................................................................. . 525 Chemical Alopecia; A Unique Case. George E . M orris, M.D., Boston.................................530 Correspondence: ' Impairment of Pulmonary Function in Anthracosilicosw. Prem ysl Petnif, Prague, Czechoslovakia.............................. ............................. ....... ............ SJ2 H urley L. Motley, PhJD., MJD., J-os Angeles............................... ........................... .............532 Obituaries; H erbert George D yktor........................ 534 Abstracts from Current L iterature.....................................................................................................S35 News and Comment...................................................................................................... 554 Books ..................... .................. ......................................................................................................., , 555 A. M . A. a r c h iv e s of Industrial Hygiene and Occupational Medicine E D IT O R IA L BOARD PHILIP DRINKER, C hief Editor $6 Sbattuek Street, B oston 15 RALPH C. LEGGO, Crockett, Cellf. H. H. SCHRENK, Pittofturgh FRANK PRINCI, ClncIniMtl CHARLES F. SHOOK S it, Toledo OSCAR A. SANDER, Milwaukee JAMES H. STERNER, Rochester, N. Y. HERBERT E. STOKlNGER, Cincinnati Volume 7 1953 PUBLISHERS AMERICAN MEDICAL ASSOCIATION CHICAGO 10, IL L . CONTENTS OF VOEUME 7 - JA N U A R Y 19S3. N U M B E R 1 PASS A ir Sampling w ith Membrane Filters. Melv*n W . F irst, Sc.D.', and Leslie Silverman, ScJX, Boston ......................................................................................................................... 1 Occupational Skin Cancer in a Group of T a r W orkers. R. R. W . Fisher, M.B., B.CH-, D .P.H ., D J .H ,, London, England............................................................................................. 12 Behavior of Mercury in the Animal Organism Following Inhalation. William F . Ashe, M.D.J Edward J. Largent, B.A.; Frank R . Dutra, M J3.; Donald M. Hubbard, Ch.E., and M orris Blackstonc, Cincinnati.......... ...................................................... .................... .. 19 Barltosis: R eport of a Case. Eugene P . Pendergrass, M.D., and Roy R. Greening, M.D., Philadelphia ................................................ .................................................................................. 44 Portable Electrostatic Precipitator Operating from 110 Volts A. C. or 6 V olts D . C, Andrew D . Hosey, B.S., and H erbert H . Jones, B.S., Cincinnati................49 Notes on Preparation of D ust' Samples for Microscopic Siaing. Melvin W , F irst, Sc.D., Boston ................................. ............ ............................................................................................ 5$ T oxidty of 2,4-DichJorophenoxyacetic Acid and 2,4,5-Trichlorophenoxyacetlc A cid: A Report on Their Acme and Chronic Toxicity in Dogs. Victor A. Drill, Ph-D,, M JD, and Tomiharu HJratrfea, M.D., D e t r o i t . . . . , . . . . . , . . , .................................................... 61 Abstracts from Current L iterature................................................................................................... fig News and Comment.................... ....................................................................................................... 86 FEBR U A R Y 1953. N U M B F it 2 Historical Relations of Medicine and Engineering. W illiam S. McCann, M.D., Rochester, N . Y ...................... ............................................................................. .......................................... 87 Urinary Excretion of Paranitrophenol Following Exposure to Parathion: Progress Report J a n Lieben, MJD.; Rudolph K . W aldman, D r. Chctn., attd Leonard K rause, M.S., H artford, Conn............. .................... ................................................................... 93 Antimony Poisoning In Industry. Lucian E . R e n , M.S., Little Bock, A rk ......................... 99 Small Radioactive Spheres for Possible U se in Medical or Biological Investigation. L. P . H atch, S .M , Upton, L. I., N- Y ............. ....................................... .................................. . 109 Occupational Health Activities and Objectives of the W orld Health Organization, Milton I . Reenter, MJX, and Oswald* L. D a Costa, M.D., Geneva, Switzerland.......... 1U Toxicology and Safe Handling of CBP-55 (Technical 1-Chloro*3-Bromopropene-1). C H , . Hine, M JD, Ph,D .; H . H . Anderson, M D .j H . D. Moon, MJD.; J. K. Kodama, B.A,j M . Morse, B , San Francisco, and N . W . Jacobsen, B .S , Emeryville, Calif.......... llg Use of Calcium Ethylenediaminetetmcctatc in Treating Heavy-Metal Poisonings Report of a Conference.Held at Massachusetts General H ospital..................... 137 Use of Calcium Ethylenediaminetetmcetate in Cases of Lead Intoxication. H , Foreman, M .D , Los Alamos, N. M e*,; H , L. H ardy, M .D , Boston; T. L. Shipman, M,T> L os Alamos, N . Mex., and E, L. Belknap, M .D , M ilw aukee...................................... 14g Buscopan In Treatm ent of Experimental Poisoning by Parathion, Methyl Parathion, and Systox. W illiam B, Deichmann, FhJD,, and Roman Rakoeay, Dipl. Ing. n ^ , Albany N- Y........... ....................................................................... . `___ ' ieo ; ! ' ' iv INDUSTRIAL HYGIENE AND OCCUPATIONAL MEDICINE FEBRU ARY --Continued FAO Comparative Inhalation Toxicitica of Four Hlogenated Hydrocarbons to R ats and Mice in the Presence of Gasoline Fires: Carbon Tetrachloride, Monochloronionobromomethenc, Difluorodibroroomethaoc, and Trifluororooftobromomethanc. Charles C Comstock and F red W . Oberst, P h .D , Army Chemical Center, M d . . . , , ....................................... 157 tt A bstracts from Current L i t e r a t u r e . . . . . . . . . . . .......................................................... ................... 168 News and Com m ent.'................. ..................................... ................................. .... ..........................186 . M A R CH 1953. N U M B E R 3 Industrial Hygiene in Britain. B, H . Harvey, M.A. (O xon.), Boston.................................. 187 Exposure of Connecticut Tobacco W orkers to Parathion. R. A. Schaefer, B.Cbcm., and G. H . V a n , B .S , H artford, C o t m . . . . . . . . ........................................... ................................ 193 Toxicological and Pharmacological Studies on Chlordano. Anthony M . Ambrose, Ph.D .: H erbert . Christensen, M .S.; Dorothy J. Robbins, B.S., Albany. Calif, and Ldland J. R ather, M D , S an Francisco....................... ............. ......................................................... 197 Evaluation of Long-Term Radiation Exposures. Duncan A. Heladay, M .A , Salt Lake City 211 Agents Diminishing Skeletal Accumulation of Lead. Norman S. MacDonald, P h D .; F lorita E m irlian . A .B.; Patricia Spain, A .B , and Donald E. Rounds, A .B , Los Angeles .............................................................................................................. ............... . 217 Examination of H eat Stress Indices: Usefulness of Such Indices for Predicting Responses of African Mine Laborers. C, H . Wyndham, M .B.; W . van der Merwe Bouwer. B.Sc.; H . F . Paterson, B.Se., and M. G. Devine, B .Sc, Johannesburg, Union of South . A frica ..................................................................................................... .......................... 221 W orking Efficiency of Africans in H e a t: Effect of V arious Saturated A ir Temperatures, W ind Velocities, and Rates of W ork. C- H . Wyndham, M B .; W . van der Merwe Bouwer, B .Sc.; H . F. Paterson. B.Sc., and M, G- Devine, B.Sc,, Johannesburg, Union of South A f r i c a . . . ................................................................................................ . -- . . . 234 Periodic H ealth Examinations- W . Leigh Cook J r , M .D , Pittsburgh........................... . 241 Improvements in the Rapid Screening Method for Lead in Urine. W . W , Woessner, Ph.D , P enns Grove, N . J , and J. Cholak, C incinnati.......................................... .......... ................. 249 Correspondence: A Rational Approach to Air-Pollution Legislation. Thom as C W orts, Pittsburgh............................................................ ........... ......................... 2S5 George E , Bast, B altim ore................................................................ .............. ...................... 257 A bstracts from Current L iterature................................................................................................. 259. Books ....................................................................................... ............ *...................... ...................... 274 .Medical Motion P ic tu re s ............................................ .............. .............................................274 A P R IL 1953. N U M B E R 4 Editorials: ' D eaths D uring the Severs F og In London and Environs, Dec. 5 to 9, 1952. Philip D rinker, Boston.................................................. ..................................... ............................... 275 Rapid Determination of Lead in Old U rine Samples. M ary O . Amdur, P h .D , Boston-- 277 Comparative Toxicity of Synthetic and N atural Glycerin, Charles H . Hinc, M D , P h D .: Hamilton H , Anderson, M D . j H enry D. Moon, M .D .; M ary K . Dunlap, D .V.M , and M argarita S . Morse, B .S , San Francisco........................................... ............................... 282 Observations on Kay, and J. Acute Toxicity Stoking'. 1 Toxicity of B u t Carl G Sr Blood and U rio Leo LaFrai Planning a St' M ethodoloi M .P.H , AntbracosiUco! Correspoadenc Statistical Activity John F . D. O. H i Obituaries; ' Paul A r Abstract frt News and C Distribution PhD ., Design of a Center. Chollnestcn InMCtiC M .D . Jane) Survey at Washb Procedure Hump' N ew M ett Readh Dermatiti: Georg Space an* Labor Abstracts News a n Books . CONTENTS OF VOLUME 7 A PRILr~Cmime& PACE Observations on Toxicity of A ldrin: I. Growth and Estru* in Rats. W . L. Ball; Kingsley Kay, and ] W . Sinclair. Ottawa, Ont., Canada................................................................ . 292 Acute Toxicity of Carnotitc O re Dust. H erbert B. iJVllson, Rochester, N . Y .; H . E. Stokinger, P h D ., Cinclnpati, and George E . Sylvester, Rochester, N, Y ............... . 301 Toxicity of Butyl Stearate. Dibutyl Sebacatc, Dibutyl Phthalate, and Methoxycthyl Oleate. Carl C-. Smith, P h D , Cincinnati............................................................................................. 310 Blood and U rine Changes in Experimental Beryllium Poisoning. C h a rle s). Spiegl, Ph.D<; Leo LaFrance, B.S., and Betty J. Ashworth, B .S , Rochester, N . Y ................................. - SI9 Planning a Study to Determine the Effect* of A ir Polution on H ealth: A Review of Methodology. A rthur F. W . Peart, M.D., D .P.H., and Gordon H. Josie, M .Sc, M .P .H , Ottawa, O n t, Canada................................................................... 326 Anthracosilicosls O ccurring in a Foundry Employee. L. E , Hamlin, M.D., C hicago... 339 Correspondence: . Statistical Analysis of Normal Human Red Blood Cells and Plasma Cholinesterase Activity Values. John F . M archand, M.D,, New Y ork....................... ............................... ........... ................ D. O- Hamblin, M .D , New Y o rk ....................................................................... ..................... Obituaries : Paul Ardeen N eal, M.D......... 353 Abstracts from Current Literature 355 News and C o m m e n t...,.................. 365 MAY 1953. N U M B E R S Distribution and Retention of C arrier-Free Rndloberyllium in the R at. C. D . Van Cleave, Ph.D ,, and C, T , K aylor, P h D , Chapel H ill, N . C . .............................................. ............. 367 Design of a New Five-Stage Cascade lmpactor. James D . Wilcox, B .S, Army Chemical Center, M d ~ . . . ............................................................................................................................* 376 Cholinesterase Response and Symptomatology from Exposure to Organic Phosphorus Insecticides. W . Taylor Sumerford, P h D , Wenatchee, W ash.; Wayland J . Hayes J r , M D , P h D , Savannah, G a.; J. Monte Johnston, M .D .; Kenneth Walker, B .S, and Janet Spillane, B .S , Wenatchee, W ash....................................................................... . 383 Survey of Insecticide Spray Practices Used in- die F ru it Orchards of N orth Central W ashington. Gordon S. Batchelor, M .S , Wenatchee, W a s h ........................................1. 399 Procedure for Weighing Fluted Filters with U se of Aluminum-Foil Envelopes. P aul A. Humphrey, S .B , and Daniel M. Morgan, B .E d , Idaho Falls I d a h o . , . . 402 N ew Method for Monitoring Air-Borne D u st P. F. H olt, P h D , and A. J . Chalk, B .Sc, Reading, E ngland........................................................................................... .............................494 Dermatitis from W ater Glass: Caused by Synergistic Action with an Alkaline D etergent George E . M orris, M D , Boston....................... ............................................. .........................411 Space and Labor-Saving Devices In the Industrial D ispensary: V II. Portable Clinical Laboratory Equipment for Field Use. Jean Spencer Felton, M .D , Oak Ridge, T e n n ... 413 A bstracts from C urrent L ite ra tu re ........................ ............. ..........................................- .............422 N ew s and Comment............................................................................ ...................................... .. 451 Books ................ .................. ............................................................................... ................. 452 { ) . I I I ! | I' : ; i . j : . . vi INDUSTRIAL HYGIENE AND OCCUPATIONAL MEDICINE JU N E 1953- N U M B E R 6 thVt Effect of Modifications of the Surface of Q uarts on Its Fibrogcnle Properties in the Lungs of Rats. E. J , K ing; G. P . Mohanty; G V- H arrison, London, England, and G. N agel' schmidt, Sheffield, England............................................................ ............................. 455 Acute Toxicity of Mineral Dusts. Jean C Dale, and E . J. King, London, E ngland............478 Adsorption of Dyes, Atnino Acids, Proteins, and Metal Hydroxides on. Q uarts. Jean C Dale and E . J . King, London, E n g l a n d . . . . . . . .................................................. ................. 484 Field Equipment for the Collection and E ralnation of Toxic and Radioactive Contaminants. W . B. H arris; H- D. LeVine, and M. Eisenbud, New Y o rk .....................................490 Spwtroehemieal Analysis of Beryllium in Biological Tissue. Janus Y. E llcnW g, Oak Ridge, Tenn., and Louis E. Owen, Lookland, O h io ,................................................................ 503 Radon Inhalation Studies In Rats. S. H. Cohn, P h D ., San Francisco; Lieutenant Com mander R, K . Skow (M .S.C.) U. S. N., and J . K . Gong, B.S., San F ra n c is c o ..,,........ 508 Hyperthermic and Pathologic Effects of Electromagnetic Radiation (350 Me). lieu ten an t Colonel John E Boysen, Medical Corps, United States A ir Force....................................... '516 Acute Narcotic Effects of Monochloromonobromomethane V apor In Rats. Charles C. Comstock; Ralph W . Fogleman, D.V.M., and F red W . Oberst. Ph.D., Army Chemical Center, Md, ................................................................................. ............................................. 326 Control of the Environment In the Prevention of Industrial Accidents. Bryan H - Harvey, M.A. (O xon), Boston.................................................................................................................... 529 Abstracts from Current' L iterature.....................................................................................................537 News and Comment............................ ........................................ ............................. UH . ' ` . . ` ' , ` . Mo l e c u i the colle been know io of the Biologic commercially. During the published desc bacteriology. T A recent Ru and notes thal Union. . The filter pared from 0 (pore volume which are si be controlled dote to 100` T hisfilte charge plays porosity filb away (H A ) Resistance t aration by s The pap* Industrial H t This stud and H arvard represent the 1.FU ten and isopore A . G. Chem! 2.Clark hi Sanitary 3 .S e stti Method, Gis A. A H C H I V E S OF Industrial Hygiene . and Occupational Medicine E D IT O R IA L BOARD P IN U P DR1NKEH. CWef E ditor 55 SM ituck Street) Boetop 15 RALPH C- LEGCO, Croekett, C altr. H . H . SCHRENK, P lttiD orgh FRANK PHlNCI, c in e tn o iti CHARLES F- SHOOK S r , Toledo OSCAR A, SANDER, Mll-wau)<c* JAKES H . STERNER. R ochester. N . T . HERBERT E . STOKINGER, Cincfamatt V olume 8 1953 PUBLISHERS AMERICAN MEDICAL ASSOCIATION CHICAGO 10, ILL. CONTENTS OF VOLUME 8 JU L Y 1953. N U M B E R 1 . m* Uwirlliosi : Sw w nary and Survey of AB Clinical Types Observed in a Twelve-Year Period. Joseph M . DeNardi, t o Lorain. Ohio; H . S. Van O rdstond, M D .; George H . Curti, M .D , and John Zielinski, M D , Cleveland.............................................................. I Industrial Hygiene in L atin America. John J. Bloomfield, B.S. In Eng., Washington, D . C ... 25 Noise and Audiometre H istories Resulting from Cotton Textile Operations. Jerome R. Cox J r , S .M , Boston; Richard H . Mansur, M .S, Augusta, Maine, and Charles R. Williams, Fh-D., Boston..................................................................... .......................... 36 Nickel Poisoning ; I. Experim ental Study of the Effects of A cute and Subacute Exposure to Nickel Carbonyl. J- F . Kincaid, P h D .; James S. Strong, P h D , and F . W illiam Simderroan, M.D.. PhJD, Philadelphia................................................... : ................... 48 Plysfcal Medicine and Rehabilitation as Related to Industrial Health. Frank H . Krusen, . M .D , Rochester, M i n n . . . . . . . . . .............................................................................................. - 61 New Approaches to th e H ealth H a is rd Evaluation of Pesticides. Kingsley Kay, P h D , Ottawa, O n t, C anada......... ............................. .......................................................- ................. 70 Obituaries: Cyril T asker....................................... *.......................................................................................... 76 Abstracts from C urrent L iterature.................................................................................................... 78 News and C o m m e n t........................................................................................................ 92 Books .......................................................................................................................................................... 95 A U G U ST 1953. N U M B E R 2 Role of the Physician in Labor Relations, B. A. Lindbcrg, Ailston, Mass.............................. ... 97 Challenge of Industry to the Medical Profession. W illiam H . Seymour, Boston...................... 102 Relationship Between the Piezoelectric Property and th e Fibrogenic Capacity of Lust. Philip C. P ra tt, M D .; Donald Bailey; Anthony B. Delahant, and A rthur J. Vorwald, M D ., Saranac Lake, N . Y . . . . . . . . . ........................... .......... .............................................. 109 Occurrence of Radon in Nonuranium Mines in Colorado. P . W . Jacoe, Denver........................118 Emanation of Radon in U ranium Mines and Control by Ventilation- E . C Tsivoglou, P h D , and H , E . Ayer, B .S , S alt Lake City........................................................................... 125 Aggravation as a F acto r in Industrial Dermatitis. Bernard Appel, M D , Lynn, Mass........... 133 Nickel Carbonyl Poisoning: R eport of a Case. John L. Carmichael, M D , Birmingham, A la. 143 Kidney Injury A fter Chronic Exposure to Inorganic Mercury. Lara Friberg, M D , Tomteheda, Sweden; Sven HammarstrSm. M D , SnndsvaB, Sweden, and A ke NystrSm, M .D , Stockholm, Sweden........ ............................................................... ........................................ 149 Occupational H asards from Fungi Causing Deep Mycoses. Stanley S. Raphael, M R , and Jan Schwarz, M D , Cincinnati........ ...................................................................................... 154 Cast of Panmyelophthisis A lter Exposure to Chtorophenothane and Benzene Hexachloride. Lars Friberg, M .D , Tomtebods, Sweden, and Johan Martensson, M D , Lund, Sw eden.. 166 Toxicity of 2-Ethylhexyl Diphenyl Phosphate: I. Immediate Toxicity and Effects of Long Term Feeding Experiments. Joseph F. Treon, P h D .; Frank R. Dutra. M D , and Frank P . Cleveland, M .D , Cincinnati..................... .......................................... ................ 170 ili iv INDUSTRIAL HYGIENE AND OCCUPATIONAL MEDICINE ' AU GUST--Continued pace. Fumes And Gtes from Selenium Rectifiers Abused by Gross Overloading. Philip Drinker, Ch-E., SeJD., Boston, and K . W ; Nelson, B.EcL, Salt Lake C ity......................................... Abstracts from Current L iterature.................................................... ! ......... ...................................i$o N ew t and Comment..............................................................................................................................2(R Books ..................................................................................................................................................... 203. S E P T E M B E R 1933. N U M B E R 3 Chronic Bronchopulmonary Disease Due to Inhalation of Sulfuric Acid Fumes. Alfred Goldman, M.D., and W illiam T . Hill, M D -, St, Louis.................................................... . 20$ Current Lines of Attack on the Smoke Problem in Britain. P eter C. G. Isaac, B.Sc. (E ng.)i S.bL, A .M J.C .E., Newcastle upon Tyne, G reat B rita in .. . . . . . . . . . . . . . . . . . . 213 Chronic O ral Toxicity of Di(2-Etbythexyt) Phthalate for R ats, Guinea Pigs, and Dogs, Charles P . Carpenter. Ph.D .; Carrol S. W e ll M.A.. and H enry P . Smyth Jr., Ph.D , Pittsburgh ........................................................................................................... .................... 219 Tetrachlorethylene Exposure in a Small Industry, H . Robert Goler, M.D., M .P.H* and H . R. Rossmiller, M.Dn Cleveland.......................................................................... .. 227 D ust Counting by the Most Probable Number Method. H arlow M. Chapman, B.S., Ch.E., Bethlehem, P a .................. .............................................................................................. ............234 Motivating Employees for Industrial Health. H erbert K. Abrams, M.D., Chicago............... 246 Physical Basis of Hearing Damage and a Tentative Damage Risk Criterion for Steady-State Noise. H ow ard G H ardy, P h D ., C hicago....................................................... ................... 250 Effect of Diet on the Susceptibility of the R at to Poisoning, by 2,4-Dinitrotoluene. Maurice E . Shiis, SeD ., and Leonard J . Goldwatcr, M.D., New Y o rk .................................. ..........262 Toxicity of 2-Ethylhexyl Diphenyl Phosphate i IL Metabolic F ate in M an and Animals. Joseph F . Treon, P h .D .; John Cappel, B.$., and H ow ard Sigmon, Cincinnati,.............. .....................................................................268 IIL Studies of tbc Extraction of Santkizer 141 from Polyvinyl Chloride Films by Food stuffs Under Various Conditions of Storage. J. Clark Koskie, M.$., St. L ouis.. . 281 IV . Skin Sensitization Studies of S antidser 141. Lawrence K . H alpern, M.D., and Richard S- W d ss/M .D ., St. Louis......................................................................... ,2 8 4 Small Chamber fo r Studying T est Atmospheres. C J. Sptegi, P h D .; L. J . Leach. B.S.; K , E Lauterbach, M A .; R. W ilson, B.S., and S , Laskin, B.S., Rochester, N , Y............. 286 Chronic O ral Toxicity of Ethyl Phthalyl Ethyl Glyeniata in R ats and Dogs. Harold G Hodge, P L D .; Elliott A. Maynard, P h D .; Harvey J. Bianchet J r , M D .; Robert E H yatt, M D ., Rochester, N . Y .; V erald K . Rowe, A.B., and H ow ard G Spencer, P h D , Midland, MMi.............................. 289 Special Reports: Threshold Limit Values fo r 1953............ .......... ............. ........................................................ 296 O C TO B ER 1953. N U M B ER 4 Relationship Between the General Practitioner and the Industrial Physldan. E arl F . Lutz, M.D* D etroit.................... 299 Experimental Studies on Cancerigenesis o f Synthetic Liquid Fuels and Petroleum Substi tutes. W . C- Hueper, M.D., Bethesda, M d.............................................. ............................. 30? Methyl Chloride Intoxication: Report of Fifteen Cases. Howard Hansen, M.D.; N . K. Weaver, M.D., and F. S, Venable, M.S., Baton Rouge, La............................................ ....... 328 CONTENTS OF VOLUME $ v ' O CTO BER -^ TAGS . , and H ta lth H azards of Boron H ydrides. Eugene H . Krackow, B A , Chemical T COW jo lte d S:[atei A rrny..........................................................................................................335 /wtnMikm?! Allergic Reactions Among W orkers in a Pcnicillln-M emiacturing p la n t: $taip|e and Inexpensive M ethod of Diagnosis and Treatment. A, Eaton Roberts, M.D,, . Malvern, P a ..................................... ......................................................................................... 340 - ct[on 0 D iaiotirable M etabolites in M an A fter Aniline Exposure. David L, Hill, A.B. Army Chemical Center, M d........................................................................................................ 347 Studies on the Toxicity and Mechanism of Action of Some N ew Insecticidal Thionopho.v (hates. Kenneth P . DuBois, Ph.D .; John Doull, PH D .; Jcre Dtroin, B A , and Oda K, Cummings, M.S., C h ic a g o .................................. ........................................................ . 350 Applications of X-Ray D iffraction Analysis h i the Environmental Field. D . Lennox, B A ,, a d J. Leroux, B A , O ttaw a, Q n t, Canada.............................................................................. 359 Toxicity Studies of Acetone Cyanohydrin and Ethylene Cyanohydrin. F . W illiam Sunderman, M.D., P h D , and John F . Kincaid, Ph.D ., Philadelphia............................................. 371 Toxicity and H azard of Dilsobotyl Ketone V apors. C. P. Carpenter, P h D .; U. C Poizanl, M .S, and C S. W eil, M .A , P ittsb u rg h ................................................................................... 377 Semiportable Air-Sampling System. L. J , Leach, B .S.; R. H . Wilson, B .S.; K . E. Lautcrbach, M A ; C- J. Spiegl, P h D ., and S. Lasldn, B .S , Rochester, N . Y................................ 382 A ttra c ts from Current L iterature.................................................................................................. .. 334 News and Comment.............. ....................................................... ........................... ................389 Books .......................................................................................... *...................................................... 390 N O V E M B E R 1953. N U M B E R 5 Fear, Frustration, and F u tility: T h e'In d u strial Aspect. Rutherford T. Johnstone; M.D., Loe Angeles....................................................................................................................................391 Toxicity of Malathon; Sum m ary of Mammalian Investigations. Lloyd W . Hazleton, P h D , and Emily G. Holland, B .S , Fall* Church, V a ...................................................... .................399 Studies in Vanadium Toxicology: Reduction in the Cystine Content of R at H air. John T. Mountain, M .S.; L ary l Lee Delker, B .S , and H . E . Stokingsr, P h D , Cincinnati......... 406 Absolute Method of Sampling and Measurement of Solid A ir-Borne Particulates; Combined Use of the Molecular F ilter Membrane and Electron Microscopy. David A Fraser, B A Cincinnati................... ...................................................................'....................... 412 SHicotis In Mica Mining in Bihar, India. H arry Heimann, M.D., Washington, D . C,; Samuel Moskowitz, Q lE , P h D , N ew Y o rk ; C. A H arihara Iyer, P h D .; M. N. Gupta, M.B., D .I.H , and N . S. M ankiker, B .S c, B .E , New Delhi, In d ia ...................420 Some Physiological Effects of Disulfur Decafluoride (StFw) A fter Intravenous Injection in Dogs: A Note on Its Toxicity to Rabbits. J: Palm er Saunders, P h D .; Milton Shoshkes, M D ,; Michael R, De Carlo, P k D ., and Ernest C. Brown, M.D., Army Chemical Center, M d.................................................... 43d Dust Sampler W hich Simulates U pper and Lower L ung Deposition. W . B. H arris and Merril Eisenbud, New Y o rk ................................................... ........................................ .. 446 Bneumoeoniosis in the Tungsten.Carbide Tool Industry: Report of Three Cases. Charles W . Miller, M .D.; M artin W . D avis,.M D .; Alfred G oldm an,.M D , and John P . Wyatt, M.D., S t Louis.............................................. 453. Studies of the Acute and Chronic Toxicity of Germanium. lieu ten an t Commander George Kosenfeld (M SC ), U .S .N , and Lieutenant (jg ) A J . W allace (M SC), U .S .N .R , Bethesda. Md.............................................................................................. ................................466 ] K .. P it:! vi INDUSTRIAL HYGIENE AND OCCUPATIONAL MEDICINE N O V EM BER --Cotil*tmi Absence of Toxic Manifestations in W orkers Exposed to Chlordane. W alter C. Alvarez,;: MX)., and Samvel Hyman, MJX, Chicago.......................................................................... Abstracts from Current L iterature............................................................. .............................. N ews and*Comment........................... . ............................................ ................ - .......................... . 4 i| Books ......................... ............. ........................... .......... ............................................................... DECEMBER S3. NUMBER 6 A cute Inhalation Toxicity of Beryllium: IV . Beryllium Fluoride at Exposure Concentra tions of One and T en Milligrams per Cubic Meter. H erbert E . Stokinger, FH.D,; Charles J. Spiegl, F h .D .; R obert E . R oot: Robert H . H all. P h .D .; Luvflle T. Stead man, P h .D .; Catherine A Stroud, M .T .; Jam es K . Scott, M .D ,; Frank A. Smith, Ph.D., and Dwight E . Gardner, B A , Rochester, N. Y ................................. . 493^ Systematic Toxicological Analysis by Spectrophotometric M ethods: I . Nonalkaloidal Organic Compounds. George W . Roche, M.S., and Harold. N. W right, P h-D , Minneapolis........................................................................................... 507'a II . Alkaloidal Poisons. Eleanor Berman, M.S., and H arold N . W right, Ph.D,, Minne 518 apolis ....................... ............................... ..................................................... .. Pharmacological Studies of Radiogermanium (GeT1) : II. Inhalation of Dusts, Commander H . C. Dudley (M S C ), U . S. N ................... .................... ............................ ............................ 528 1H ffl N ote on Mien Dust Inbalation. H arry Hcimann. M,D,, Washington, D, C ; Samuel Mos kowitz, Ch.IL, P h .D , New Y ork; C. R . H arih ara Iyer, P h .D .; M . N . Gupta, M .B, and N. S. Manldker, B .S c, B E ., New Delhi, India................ ........................... 531 Connecticut Program for Safe Aerial Application of Pesticides. Jan J-ieben, M.D., Hartford, Conn. ................................................................................................ ......................................... .. 533 Vinyl P lastics: T heir Dermatological and Chemical Aspects. George E . M orris, M.D,, Boston ............................................ ............................................................................. ............... 535 Synthetic R ubbers: T heir Chemistry and Dermatological Aspects. George E. Morris. M JX, B o s to n ...................................................................... ................................................... .. 540 Neuroses and Compensation: Chronic Psychiatric Disorders Following In ju ry o r Stress in Compensable Situations. I. Review of die Literature. Alex D. Pokoroy, M.D., and Floy J . Moore, MX)., Houston, T exas........................................................ - .................. .. 547 Toxicity of Silica: I. Silica Solutions. Lester D. Scheel; E. Flcisher, and F . W . Klemperer. Trudeau, N . Y .............................................................................................................................. 564 Fluctuations of Breath Radon In Subjects Seated a t Rest. E . J, Martin, M.D., and J . K. W . Ferguson, M.D,, Toronto, C a n a d a ....................................................................- .............. 574 Serious Poisoning by Hexachlorocydohexane: Clinical and Laboratory Observations on Five Cases. E . Danopoulos; K Melisrinos, and G. Katsas, Athens, G reece....................... ... 582 Correspondence: Kidney In ju ry A fter Chronic Exposure to Inorganic Mercury. Leonard J. Goldwater, M.D,, N ew Y o r k ....................... ...................................................................................... . . . 19 . ''9 9'ijH S 9 1 1[ 1 1 1 I 11 ' Abstracts from Current L iteratu re.............................................................................. ................. Books .................................................. ............................................................................................. Arobi VOM* TX Nt in f! w or atU in d in q la< CVl Re by Pe Aw 1:1 i1*i* l A* IME* A* a r c h i v e s of Industrial Hygiene and Occupational Medicine ED ITO R IA L BOARD PHILIP DRINKER, Chir Editor IS Statinole S tm t. Boato IS CHRISTOPHER LUOGO. Crockett Colti. OSCAR A, SANDER. Mllrmnlee# ROBERT O'CONNOR. Restart H. . SCHRENK. PltWjvrgh TRANS TRINCI, Cincinnati CHARLES V- SHOOK SB* Toledo HERBERT E. STOKINGRR, Cincinnati JU L Y 1954 VOLUME 10 NUMBER 1 Section n Index to A . M . A . Archives op Industrial Hygiene and Occupation al Medicine fimi th e P eriod J anuary through J une, 1954 Publidied Monthly by AMERICAN MEDICAL ASSOCIATION 5 NORTH DEARBORN STREET * CHICAGO ID, ILLINOIS E*nt0a,ieUdnudeSr etchoendAdctm<AMKeatrtcehr Tan. 4, is*, at the Foetofllce at Chi* 3, 187?. Annual SnW lptton, R8.0Q CO N T I N T S * U fb u d A tU c le A Studies of Phosphorus Intoxication paos Dorothy / . Buchanan, Ph.D.; Me* V. Sigal Jr., PhD,; C, S. Robinson, PhD,; Katherine Pope, BS.; Mary Mlle Ferguson, BS,, and John B. Thotniton, M.D., Nashville, Term. ............... . . . . ..................... .......................................................................... 1 Comparative Exchange of Calcium, Leod, and Radioactive Lead in Dogs / , Alfred Calhoun, MD.; Regina McLean, A.B.; 1, Cramer Hudson, PhD., and Joseph C. Aub, MD., Boston................................................................................... . . . . . . . . . . . 9 Participation o f a Labor Union in the Study of Problems of Psychiatry in Industry Louis L, Tunen, MU., St. Louis. . . ...................................... - ............ .................... . ........... 23 Toxicity of Silica Lester D, Scheel, PhD.! B. Smith, BS.; J. Van Riper, BS., and E, Fleisher, 8S,, Trudeau, H. V. . ................... . . . . . . .......... . . . . . .............................. ......................... 29 Physiological Responses to Parathion Exposure Rudolph K, Waldman, Dr. Chetn.; Jan Lieben, MD., and Leonard Krause, MDV Hartford, Cam....................................... ................................................ ............................... .. 37 Comparative Toxicity of Two Vinyl-Substituted Phosphates 3 \ i i lyre K. Kodam; Margarita S, Morse; Hamilton H. Anderson-Mary K. Dunlap, and *\ Charles H. M m , San Francisco........ ............................................... ............................... .. 45 5! Two Chambers for Use in Exposing Laboratory Animals to the Inhalation !! of Aerosols ; Edward C. J, Urban, Saronae Lake, N. Y , . . . ...................................................... . 62 j Efficiency Studies o f the Electrostatic Precipitator j Kenneth E. Lauterboch, MA.; Thoms T. Mercer, MA.; Alasfair D. Hayes. MA.. j . __ and Paul E. Morrow,PhD., Rochester, if. ............................................................... 69 } . j fa fu la * S je p & U m e n U j Pj>A bitrqcts from Current L iteratu re.......................................................................... . t 76 i ft- News and Com m ent............ 86 IT - ........................................................................................................ I C i> CONTENTS O riginal A rlk l t Polonium in Uri" of Miners Exposed to Radon rAQ fo r y S u ilser, M S . , m d Jo h n B . H u n k , P h D ., Rochester, N , Y . ...........- .................... 89 Industrial and Laboratory Evaluation of a Silicone Protective Cream R aym ond R . S u t k M , M D ., C incinnati......................................................................... 101 Migration of Inorganic Salts in Bone as Measured By Radioactive Lead and by Alizarin R egina M cLean, A D : ; J . A lfred C a lh o m , M D ,, and Joseph C, A n b , M D ., B oston 113 Skin Penetration by Diamines of th e Benzidine Group I. W itter M eigs, M D .; Lends J. Sciorini, P h D * M m Haven,. C om ., and W aiter A . Van Sandt, MDMV Berkeley, Calif............................ ........................................ . 122 Executive Health Programs George X . Somders, MD., New York........ ............................... ..................................... .. 133 Studies on Phosphorus Intoxication Max V. Sigal Jr* PhD.; Dorothy J. Buchanan, PhD., and C. S. Robhuon, Ph.t)., Noshvifle, Tern............................. ................................ .........................................................142 Dilemma of Official Health Agencies as to Court Appearance William G. Predrick, ScD.. Detroit................................................ ........................................ 148 inatte Hydrocarbons J * I.. fivtenc in the Lat Angele Atmosphere and the Carcinogenicity of Atmospheric Extracts Paul Kotin, M D .; H ans L Folk, P h D .; Pani M oder, P h D ., and M arilyn Thomas, B A * L o s A tig e te t................................... ................................................................... 1S3 II. Fresence la the Fortkaiate Phase of Gowline-Englne Exhausts end the Cerchwgenkity of Eschenst Extracts P aid K otin, M D .; H o n s L . F a lk, P h D , an d M arilyn T hom as, B A * L o t A n g ele s. . . . 164 Regular Deportments Abstracts from Current Literature............................................................. ................... 178 News and Com m ent....... .................................................................................................... 182 TABLE OF CONTI k O RIG INAL ARTICLES Public Health Aspects of Atomic Power Development Shields Warm, M.D., Boston...................................................... ................. 183 -Aouearance of Carcinoma Following Single Exposure to o Refrigeration ^ * PP Ammonia-Oil Mixture uirhAfl B Shimhtn, M X,: A. A. de Lortmkr, MX).; J. Russell Mitchell, MX., and. % Son Francisco........................................................................ 186 Silicone Protective Creams George & Morris, MX., Boston............................................ . ......... ................................... 194 Toxicology of Hydrazine Stephen Krop, PhX., Army Chemical Center. Md............................................................ 199 lead and Coproporphyrin Excretion of Patients Treated with EDTA Beniamin F . W. Ruofolo, MX)., and Hem * B, Enins, Ph.D., Boston..........................205 Irritating and Sensitizing Effects of Two Polymeric Plasticizers F. William Sunderman, N X ., PhD., Philadelphia, tend Harvey B. Haag, M.D., Rich mond, Va.................................................................... ......................*............................ .. 210 ^ t o l y s e c of Biological M aterials as Indices of Exposure to Organic ^ Solvents Hetvey B. Elhint, PhJ)., Boston......................................................................... 212 ^R esponse of Rats to Repeated Inhalation of Ethylnediamine Vapors U, C. Possorn, MS., and C. P. Carpenter, PhJ)., Pittsburgh......................... 223 Toxicological Studies on p-Tertiary-Butyltoluene ' SPECIAL REPORTS Interim Report on Air Pollution ' A, T. Rossano Jrv Boston..................... ......................... Air Pollution and the London Fog of December, 1952 PftBip Drinker, Boston............................................................... 247 Third International Conference of Experts on Pneumoconiosis. Sydney, Australia, 1950 Philip Drinker, Boston............................................................................................... 249 REGULAR DEPARTMENTS Abstracts from Current Literature Hew* ond Comment........................ TABLE OF contents O RIG INAL ARTICLES Deposition of Wind-Boma Particles on Human Skin *; E CabrUlU A w l, MA,, and Doris Pury, BA., A m y Chemical Center, Md........273 Some Reactions Between Inert Dusts and Proteins R. F- Hounam, BjSc., A. Inti. P., Wantage, Berks, England.................................284 Statistical Control of Fluorescent Particle Tracer Studies F, R. Holden, PhD.; F. W. Drtseh, PhD., and R.D. Codie, Ph.D., Stanford, Calif.,. 291 Foundry W orkers' Pneumoconiosis in Switzerland (Anthracosilicosis) /. R. RHilner, MD., Zurich, Switterland............................................................... 297 Observations on Toxicity of Aldrin M, Crtoier, MAc.; IV. L. Ball, Ph.D., and Kingsley Kay, PhD., Ottawa, Canada-- 306 Effect of Cortisone on Experimental Silicosis in Rots Bruno Marenghi, MD., and Lorensa Rota, MD-, Milan, Italy......... . . . . ................ 315 Colorimetric Method for Determination of Red Blood Ceil Cholinesterase Activity* in W hole Blood Joseph H. Fleithtr, MA.PM., and Eleanor J. Pope, AM., Army Chemieol Center, Md., 323 CORRESPONDENCE Redon Inhalation Studies in Rats Sidney Rust, London, England................................................................. 333 Stanton H, Cohn, San Francisco................ . ............................... ....................... 335 % REGULAR DEPARTMENTS Abstracts from Current L iterature........................................................ 335 Hews and Comment.............................. 359 ta ble of c o n t e n t s O RIG INAL ARTICLES SAGE C h t Rocntgenogrophic Study of Employees in a Large Pharmaceutical P lant W.G. C. Mxmrae, M.D., Pomona, N, Y............. .......................................*-*......... . 361 Ozone Toxicity Herbert & Stikinger, PhD., Ctn^wnoK...................................................................................366 . Occupational Arsenic Poisoning May R. Mvytrs, MD,, Neva Yarh.......................................................... ............................- 384 Tone and Fibrosing Action of Submicroscopic Particles of Amorphous Silica A. Policafd, MJ>., PhD., ant A. CaUrt, M.D., Parti......................................................... 389 Bromethymoi Blue Screening Test J, H. Woifiie, MS)., and G. D. Winter, BS., Linden, N .J .................................................. 396 Endocrine Functions in Silicotics Jifi VwkoW, MJD^ Bma, CMchoAevahia.. . . . . . . . ........................... 402 Studies in Vanadium Toxicology N . A, Talvitu, BS., and W. D , Wagner, BS., Chuinnoti................................................ 414 REGULAR DEPARTM ENTS Abstracts from Current L iteratu re............................................ ........ ...........................423 News ond C om m ent........................................................ .......................... ......................445 Bottai. } m m *. v - x ' j p *i ' ^ ' / . \ 1 T A B L E O F C C f N T f e k M - i '> ' * J fxperimentol Lng Cancer ' #<,J>/rt JS. Hr*"'* an<i ED ITO RIALS \ ? / ' T ARTHUV- " PA0* D rin ke r..................... ............................ *.................... 449 O RIG INAL ARTICLES W o rk m e n 's Compensation Under the Federal Laws M orion* IV. G r ig s H C h i c a g o . . . : . : . . . ............................. .......................................... 451 Muscle Spasm in M anual Laborers A Millunen, M .A .; M . I. K am onen, P hJ)., M 3 .; J. K tklberg, M .A ., and R . Lam iniitpf, M A ., H e lsin k i............................................................................. -.................476 Microscopic Observations Correlating Tonicity of Beryllium Oxide with Crystal Structur (!. C. C n n * * , B S .,a n d IV . C. V andeM arh. B S V R ochester, N . Y ........................... 481 Carcinogenic Studies on Adsorbates of Industrially Polluted Raw and Finished W ater Supplies . IV. C. fiuepcr, M J>,, Beihesda, M d ., and C. C. R u ch h o ft, BJ>, Cincinnati............ . 488 Some Practical Aspects of Industrial Noise Measurement ' Louis /. P r o d s J r., S 3 . , H artford, C onn.................... ............................................ 496 Adsorption of Protein on Silica Surfaces . P, P. M olt and J. E . L . B ow eoti, R eading. E n g la n d .............................................. . 503 Dermatitis from W ateriest Hand Cleaners . George E. M orris, M .D ., B osto n.................................................................................... 507 Toxicology of Mono*, Di-, and Tri-Propylene Glycol Methyl Ethers V, K . Rowe, M 3 .; D , D. MeCollister, B 3 ,; H , C. Spencer, PhJ>.; P. O yen; R , L . . H ollingsworth, M 3 ., M idland, M ich., and V , A . D rill, Ph.D -, M .D .. D etro it..............509 Problem Drinking in Industry Thomas H , H ogshead, M 3 . , W tim in g ion, D eL ........., ....... . ............... ................. 526 SPECIAL REPORTS ' Threshold Limit Yalues for 1954.................................. ............................................... 530 REGULAR DEPARTM ENTS 1 Hews and Comment................................................. ............................. .............. ........... 535 ...................................................................... ; ..........................................536 ; *" *1 fI4T 1I1 t a b l e of c o n t e n t s o r ig in a l a r t ic le s Meteorology I" Air-Pollution Engineering FACE Canto B>BAl **>KS-i ^ m r Robintm,. MS-, and Pale S , Hutchison, B.S., Stan- ^ /rtf, Ckif. ........................................................................... *........... .............................. 1 physical Rehabilitation and Reemployment of the Handicapped Frank H. &#, MP., Rochester, Mi...................................................................... 11 Industrial Air-Sampling for Anthrax Bacteria Morris A. Gordon, PhD.; Max D. Moody, PhP.; Arm M. Barton, BS,, and Frank M. Boyd. M.S., Atlanta.......................................... .................. - .............................................. 16 Mineral Content of the Lungs After Exposure to Asbestos Dust F. Knox. MP., and / . Beattie, UP.. Rochdale, England.. ...............................................23 Distribution of Mineral Particles ond fibers in the Lung After Exposure to Asbestos Dust . j,F. Knox, M.B., and J. Beattie, MP,, Rochdale, England............................................... 30 Botch Processing of Film for Radiation Protection of Personnel R. J. MagUl, Berkeley. Calif......................................... . .................................................. 37 "Why Doesn't the W orker's Skin Clear Up?" George B. Morris, MP.r Boston.. . . ........................... ...........................................................>- 43 Problems of Health in th e M arketing of Chemicals . V. K. Rowe, MS^ and E. M. Admte, PhD., Midland, Mich............................................. SO Radon Levels Found in Mines m New York State Saul J. Harris, B S n Hew York................................................................................................ 54 Range-Finding Toxicity D ata Henry P. Smyth Jr,, PhP.; Charles P. Carpenter, PhD.; Carrot S. Weil, MP.,, and Uroano C. Potzani, MS* Pittsburgh,....................... ... . .....................................................61 Gas-Mask Protection Against Decaborano . Wiltim FT. HU!, PAD., and J. L. Svkbriy, PhD., PUtsburgk......................................... 69 SPECIAL ARTICLES Renew of Literature on Health Hazards of M etals Sherman S. PMo, MD., Denver............... .......................... ........................................... 77 . REGULAR DEPARTMENTS . Abstracts from Current L iteratu re................... ...............................................................79 Hews ond Comment............................................................ ............ ............ . 87 Books t a b l e of c o n t e n t s ORIGINAL ARTICLES FACS Smdy of Five Years of Employee Counseling in an Industrial Medical Program Hanld A. Vomchen, MD.; Joseph M. Mason, MS., and Milton H. Kronenberg, . MD,, Peoria, III....................................... 91 Pulmonary Penetration of Particles Administered by Intratracheal Insufflation tiervw Cmber, MS,; Theodore F. Hdteh, S.M.; Joseph A. Watson, MS., and Thoms B, Gmcci, BS., Pittsburgh..................................... 124 /T richloroethylene and Dichloroethylene Poisoning Robert $. MrBtmeg, MD., Flushing, ft. Y ........................... ........................................... 130 /Trichloroethylene Toxicity Morris Kleinfekt, M.D., and Irving R. Tabershaw, MD., Nevi York................................. 134 Hoelth Howards In Tunnel Construction George L. Wilson, B S , and Harvey J. Roberts, BS., Charleston, W. Va....................... 142 / D i r e c t Field Determination of Lead in Air Mary 0, Atndur, PhD., and Leslie Silverman, ScD., Boston............................................. 152 Problems in the Study of Decaborane and Possible Therapy of Its Poisoning Versa V. Cole, PhD,, MD.; David L. Hill, AD., and AHi H. Oikemus, Army Chemical Center, M i.......... .................................... .................................................... ....................... IS Acute and Subacute Toxicity of Cyclethrin C. P. Carpenter, PhD.; C, S. Wed, MA.; V. C. Possenti, M.S., and H. F. Smyth Jr4 PhD., Pittsburgh...... ................................................................................................................ 1<>2 REGULAR DEPARTMENTS Abstracts from Current Literature .........................................................................l $9 "News and Comment................................................................................... .................... 181 Books 181 table of contents ORIGINAL ARTICLES Polarographie Determination of Lead in Blood PAOS AusuoU m n i e r , M.S. (Stockholm), and Carl-Eric HolmqiHsl, Chm. Eng. (StockM m h M J. (Harvard), Tomteboda, Sweden...................................................................... 183 Erythrocytic Inclusion Bodies in tho Blood of Chemical Workers Janm P. Hughes, MD., and Joseph F. Treon, Ph.D,, Cincinnati....................................... 192 ifteosuremertt of Air Pollution . i / : J. Cholok, a j , Cincinnati, .......................................................................................................203 v-fojclcity Studies of Cobalt Carbonyls ^ JohH p Kincaid, PhD.; Jam** S. Strong, PhD., and P, Wliom Sunderman, MD Ph.D\ Philadelphia..................................................................................................................210 Inhalation Toxicology of Tetranitrom ethane . Henry / . Horn, MD., Fails Church, Fa........................................................................ .......... 213 Sickness Absentee Rate in Younger and Older Workers in a Small Manufacturing Plant . Guy H. Fish MD,, Montreal, Canada................................................................................ 223 Experimental Administration of Ertiylenediamme-Tetreacetic Acid in Plutonium Poisoning . Herrs Foreman. MD- Los Alamos, H. M.; Philip A. Fuqua, MD., and William D. Norwood, M.D.., Richland, Wash........................................................................................... 220 Berylliosis if. S. Fan Orddnmd, MD., Cleveland............................................................................... . * 232 Medical Service Program of th e Sidney Hillman Health Center of New York Morris Brand, MD., Hew York.........................- ................................................................... 235 SCIENTIFIC EXHIBITS Rehabilitation of Spinal Cord ln)aries . W. Scott Allan, Boston.............................................. . . ................. ...........................................248 correspondence | / /SHicone Protective Creams: A Clinical Study . C. C. Currie, Midland, Mich..................................................... . ...................................254 George E, Morris, MD^ Boston................. ............................... . ................................... 254 regular departm ents Abstracts from Current Literature.......... ........................................... ........................... 257 News and Comment............................................................................................................270 Books TABLE OF CONTENTS : o r ig in a l a r t ic le s Protection from Aircraft Noise Major Horace 0. Parrack, United State* Air Force... investigation of Air Pollution Paul Kotin, MX)., Lot Angeles............... - ...................... PAGE . 273 . 288 Benign Tin Oxide Pneumoconiosis . Georg* Spencer, M .D ^ and W illiam C. W yeo ff, M X )., P ittsb u rg h.......................... 29$ Acute Toxicity Studies of Decaborane and Pentaborane by inhalation I . L. S vtrb ely, PhX>,, P i t t s b u r g h ..,........................ ................................. .................298 Subacute Toxicity of Decaborane and Pentaborane Yapors J. L. Svkbely, PhJ)., Pittsburgh................................ .....................................30$ Treatment of Organic Lead (Tetraethyl) Intoxication with Edathamil CalciuiptDisodiam Karl V. KitsmEler, MX).; Jacob Cholak, Ch.E., and Robert A. Kehoe, M.D., Cin cinnati .......................-..................................................... .................... 312 Inhalation Toxicity of Ninety Per Cent Hydrogen Peroxide Vapor Fred W. Oberst, Ph.D.; Charles C. Comstock, B,, and Ethel B. Hockley, M.S.,*ecifh the Technical Assistance of Lorraine Lawson, BS-, and Earle Greene, Army Chemi cal Center, M d........................................................................................ 319 X'Radiation from Electronic Power Tubes S. C. Ballard, Boston.................................................................................. 328 Hematological Investigation on Workers Exposed to Manganese Dust Branko Kcsii, MX)., and Vera HSuslcr, DXf., Zagreb, Croatia, Yugoslavia.............. 336 D. D. T. Intoxication In a Family of Southern Taiwan H. C. Hsieh, MX)., CVaa-Chow, Ping-Tong, Taman (Formosa)............................ 344 REGULAR DEPARTAMENTS Abstracts from Current L i t e r a t u r e .......................... ..................................................347 TABLE OF CONTENTS ORIGINAL ARTICLES Ventilation of Uranium Mines E, c Tsivogfou, PkD., Cindnnati, and H. E. Auer, B.S., Salt Lake City, Atmospheric Monitoring for Alpha Emitters Using Molecular Filter Membranes Thomas T. Mercer, BA., Seattle Portable Electrostatic Dust Sampler with Electronic Air Flow 2?, G, Beadle; P. H. Kino,-and P, J. Blignout, Johannesburg, Transvaal, Union of South Africa................................................................................. ........................................... 381 induction with Surgical Talc and Transplantation of Granulation Tissue in Cheek Poach of Golden Hamster George R. Bernard, PhD,; Donald I. Pall, Ph.D., and Rojendra G. Desai, M.D., Boston 390 Occupational Fractures Among Civilian Employees a t a United States Naval Shipyard . ' Warren R, Guild, MD., Boston,..,................. . .............................. .......................................397 Hew Environmental Respiratory Disease (Yokohama Asthma) ' Lieutenant Cohmel Tyrem E. Huber; Major Sheldon W. Joseph; Major Edward Knoblock. Medical Corps, United States Army; Lieutenant PaulL. Redfeam, Medical Sendee Corps, United States Army, and James A. Karakawa. Washington, D iC .... 399 Toxicity of the Oxides of Nitrogen L Introduction mid Apparatus Edward Le B. Gray, PhD,; Stanley B. Goldberg, BA., and Francis M. Patton, BS,, Army Chemical Center, MS.....................................................................................................409 II. A n ti InliafaHsu Toxicity of Nitrogen Dioxide, Rod Faming Nitric Acid, and White Fuming Nitric Arid Edward Le B. Gray, PhD,; Francis M. Potion, BS.; Stanley B. Goldberg, BA., and Eara Kaplan, B.S., Army Chemical Center, Md........... ..........................................................418 lU. effect of Chronic Expoeure to Low Concontratienx of Vapors from Red Fuming Nitric Add E>` ` ' " ~ ~ Stanley B. Goldberg, B A , and Francis M. Patton, BS., SCIENTIFIC EXHIBITS Accident Syndrome--A Clinical Approach Morris S. Schulcinger, MD., Cincinnali,........................... REGULAR DEPARTMENTS Abstracts from Current Literature News and Com m ent...................... ...4 2 6 434 . 452 / 1 K'i TABLE OF CONTENTS - ORIGINAL ARTICLES Iffcets of Inhalation of Low Concentrations o f Sulfur Dioxide upon page Man and Other Mammals Istfof Greemaald, PhD., New Y o r k . . .............................................. ................ 435 Inhalation Toxicity of Hydrazine Vapor Charles C. Comstock; Lorraine H. Ltmoti; Earle A. Greene, and Fred W. Obertf, PhD., Army Chemical Center, Md................. . . . ............................................................. Treatment of Lead Colic with Cortisone and Corticotropin Enrico C. Figlieni, Milan............................................. .................................................... 491 Food Usage a n d Food Habits of Older Workers Charlotte M, Yomg, PhD.; Gordon F. Streib, PhD^ and Betty Jean Greer, M.NS., Ithaca, N. .................................................................................................................................... SOI Foundry W orkers' Pneumoconiosis O . A . S a n d er, M D ., M ilw a u k e e ....... .......................................... .............................512 Health Hazards Involved in Use of Parathion in Fruit Orchards of North Central Washington Gordon S. Batchelor, MS., and Kenneth C. Walker, BS., Wenatchee. Wash............... 322 Treatment of Inorganic Lead Poisoning with Edothamil Calcium-Disodium Elston L. Belknap, MD., and Margaret C. Perry, BA., MA., Milwaukee................. S30 OBITUARIES James Stevens Simmons, M.D.............................................. 548 REGULAR DEPARTMENTS Abstracts from Current Literature.................................................... $50 Hews and Comment.................... .................................... - .............................. . ............. 538 A. M . A. A R C H I V E S OF Industrial Health E D IT O R IA L BOARD PHILIP HRJNKBR. CWaf Editor 55 SMrttw* Street, Boston IS CHRISTOPHER LEGGO, Crockett. Calli. OSCA A. SANBEfi, Milwaukee ROBERT O'CONNOR, Boato H . H . SCHRENK, Plttefcargh CARL M. PETERSON, CMeego CHARLES F . SHOOK, Toledo FRANK PR1NC1, Cincinnati HERBERT E. STOK1NGER, Clnotnnntl AUSTIN SUITS, Editor, A. M, A, Bclrettflc Publications GILBERT S. COOPER, Mantelair Editor, Bpoolaltj Journal Vo l u m e 11 1985 PUBLISHERS , AMERICAN MEDICAL ASSOCIATION CHICAGO 10, DLL. SUBJECT INDEX TO VOLUME 11 Thi following Index contain an alphabetical list of significant subject presented a this , ^ tra c ts are dexed by category under the heading "A n s m c i s . '' Books reviewed V<"Tit alphabetically by title under the heading "Books." Obituaries and death notiees are ^iated under the heading "D eaths," Absenteeism: sickness, * 2 8 5 and .their preventjon; protective eijuiprocnt, 44ft determination of Eir-bomc contaminants, S4, 266, 354, 44ft $36 - s r t f 284 544 industrial toxicology, 79,157, 258. 3S0, 440.,535 legal medicine, 181, 36$, 538 mtdicitK and surgery, 263. SSi, 44$ , occupational diseases and hazards, 13, 174, 253, 349, 436, 5 .; _ physiology and nutrition, 72, 173,435 radioactive substances and x-ray, 181, 268, 356. 449, 539 . ventilating, air conditioning, and engineering control, 85, 181, 267, 538 Accidents meefieri aspects, 453 syndrome, 66 Aerosols: synergistic effects, 297 Air pollution la American cities, 28(1 committee report, 513 Detroti-Wmdsor etudy, pre test of forms nd tech- nwtuei, 47 health b a w d s from, 397 Air sampling of dost, 212 physics of particle-size anal ysis, 431 Of smaii particulates, 422 Amyt nitrate: toxicity of vapor, 290 Amhraeosie, 166, 168 Antimony trfpxMe: toxicologic . study, 473, 479 Asfwstosis tGffcremiatcd from other pneumoconioses, 208 "mehenat a b n o r m a litie s , from, 196 ll^ ' a t and mill workers, Wbology, 185 Asbestosis--Continued roentgenologic aspects, 189 scientific exhibits, 165 Atomic energy: personal pro tection in atomic industry, 42 B B A l: See Dunercaprol Benzene hexachlorido: poison in g from, 457 Benzidines; urinary output estimation, 420 Beryllium intratracheal imection of Be* In rat, 375 pneumoconiosis from, 164 poisoning, 273 Blood: red cell cholinesterase activity, 332 Booxs _ . , A ir Pollution: Bibliography (Davenport and Morgis), A ir Pollution and Com munity Health (M ills), 270 Compressed A ir Illness: Investigation During Con struction of Tyne Tunnel, 1948-50 (Patou and W il der), 87 Flow and F an: Principles of Moving A ir Through Ducts (B erry), 271 Histopathology of 5km, Ed. 2 (Lever), 272 Industrial Dust, Ed, 2 (D rinker ra d H atch), 540 Industrial V en ti la t io n : Manual of Recommended Practice, Ed. 3 (American Conference of Govern mental Industrial Hygientots), 360 Lehrbuch dcr A rbeitsfa-' idene: Band II . SperieUe Bcntfchygicno (Koelsch), 358 Modern Occupational Medi cine (Fleming and others, eds.), 359 Nontuberculous Diseases of Chest (Banyai, td.), 452 Occupational Health and Safety legislation (U. S. Public Health Sendee), 452 Books--Continued Pneumoconiosis Abstracts, Vol. 2 (Middleton, ed.), 451 Radioactive W aste Disposal in Ocean (U. S. D ep't of Commerce), 452 Symposium o n F a t i g u e (Floyd and W dford, eds.), 88 Symposium on Homan F ac tors in Equipment Design (Floyd and Welford, eds,), 270 Toxicologic ties prodults phytophamtaceutiqUM (Fabre and T rubant), 451 Verhandiungen dcr deut schen Geseliechan fur A rbeitssdnita: Band 11 Staube, Gase, DSmpfe (Stidnkopff), 359 W orking Fitness of Older M en (C lark), 451 Books: Council on Industrial Health list, 343 Brass-foundry operations: lead intoxication from, 107 Byssinosis, 164 Calcium ethylencdiamine-tetraacetate; See Edathatnil calcium Cancer: See Carcinogens Carcinogens diesel-engine exhausts, 113 selection of chemicals for carcinogenic s c r e e n in g , 494 C ataract: radiation, 305 Chemicals physically toxic, 315 threshold lim it values for 1955, 521 Cholinesterase: ted cell ac tivity in whole blood, 332 Chromium compounds dermatitis from chrome glue, 368 dermatologic a s p e c ts o f Chromate problem, 361 edatham ii calcium for chrome ulcers, 123 Coat mining pneumoconiosis classification of roentgeno gram s in, 17 epidemiological studies In Great Britain, 2$ ; 5 INDUSTRIAI H D Dbath : Thompson, Lewie Rycrs, 25i . Decaborane 4 acute toxicity studies, 132 effect of repeated doses, 138 Dermatitis; "See also under Chromium compounds contact, under O ntario W orkmen's Compensation Act, 372 Diesel engines amyl nitrate in fuel, toxicity of, 290 aromatic hydrocarbons In exhausts, 113 Dimercaprol: for mercury poisoning, 231 D iptcrex: toxicity and mecha nism, 53 Ditertiarybutyhncthylphenol: toxicity of, 93 D u st; air-borne, sampling of, 212 insecticide*--Continued Systox, 324 toxicity of Hexachlorocydopentadienc, 459 Iron rolling mills: radiation cataract in, 305 L Lead fume, filter papers for samp ling of, 243 intoxication in brass-foundry operations, 107 urinary, effect of edathamil calcium and dimercaprol, 231 Lungs: See also Asbcstosis; Pneumoconiosis; Silicosis occupational diseases, 183; functional abnormalities in fibrosto of, 196 partitional respirometry, 142 thorium effeet, 234 E _ M Fdatharnfl calcium for chrome ulcers of skin, 123 for mercury poisoning, 231 M ercury poisoning; edathamil calcium and dimercaprol for, 231 P F ilter papers: for sampling lead fume, 243 Fluorescent tubes: toxicity of phosphors, 473, 479 Fluoride atmospheric, ion exchange resins m determination of, 61 metaboiism, _urinary excre tion by rabbit after renal tube injury, 2 Food processing: toxicity of ditertiarybutylmethylphenol, 93 Handicapped: employment U. S. government, 450 Hescachlorocyclopentadiene toxicity of, 459 H ydrazine; subacute toxic 413 Hydrocarbons,: aromatic, diesel-engine exhausts, 1 Industrial H ealth, Council on: selected publications list. 343 Insecticides ' benzene hexachloride poison ing, 457 dipterex, toxicity and mecha nism, 53 parathion: ' drifting dust hazard,, 403; spray con centrations and residues, 408 6 N N bws a h p Comment, 101. 120, 217,289,296, 450, 472 Nitromethanc : toxicity of, 102 O Occupational health programs, 393 Organophospborus compounds, P Parathion drifting dust hazard, 403 spray concentrations and residues, 408 Particle-size analysis, 431 Particulates, air-bom : samp lin g technique; 422 Periodicals: Council on Indus trial H ealth list, 343 Petroleum Industry: health of w orker, 126 - Phosphors, calcium halophos phate: toxicologic study, _ 473, 479 . P ho sp h o ru s; toxicity of organophosphorus c o m pounds, 487 . Pneumoconiosis: Sec also As- bestosis; Silicosis classification of roentgeno gram s in, 17 coal miners', epidemiological studies in Great Britain, 2 differential diagnosis, 208 scientific exhibit, 159 Tanning industry; chrott ulcers, edathamil calciu for, 123 Thorium refinery: indtutri hygiene and medical $u vey of, 234 , Threshold limit values f< 19SS, 521 Toxicity, plysical, of icals, 315 U United States Q vil S employment of physl handicapped, 450 United States N avy: physi fitness of executives shipyard, 121 United States Public Hep Service: occupationa health program, 393 U ranium : particle mein it n a/ TTeOe flllfiti V Vanadium : bronchitis from, 505 W W o r k m e n 's compensation: contact dermatitis under O ntario act, 3?2 SUBJECT INDEX TO VOLUME 12 T he following Index contain an alphabetical list of significant subjects presented in this volume. Abstracts are indexed by category under the heading "A bstracts." Books reviewed arc listed alphabetically by title under the heading "B ooks." Obituaries and death notices are Indexed under the heading "Deaths." Occupational health news compiled by the United States H ealth Service is indexed separately under the heading "O ccupational H ea l th N ew s." A A b rin ; lethal Jewelry, 468 Absenteeism: sickness, 592 A bstracts accidents and their preven tion ; protective equipment, 456, 562, 671 determination of air-borne contaminants, 454,559,665 environmental conditions, 453, 558 general, 543 industrial toxicology, 450, 5 5 2 ,6 legal medicine. 671 medicine and surgery, 4S1, 557 occupational diseases and hazards, 545, 657 radioactive substances and x-ray, 456, 672 ventilating, air conditioning, and engineering control, 455, 561,667 A ir pollution (editorial), 583 in Florida, 567 Public H ealth Service com munity program, 462 A ir sampling: photomicrogra phy of air-home particles, 584 Aluminum demonstration in animal tis sues, 218 in silicosis control: in cer amic industry, 247; ex perimental, 229; in foun dry, 221; in gold nntog 250 Ammonia: in air, deternuna-. tlon of, 511 Asbestos t pulmonary disability In workers, 198 B Barium sulfate i radioactive dust, pulmonary effects, 268 Battery workers: edaftamil calcium-disodium for lead poisoning in, 528 Bauxite industry: health survcy in British Guiana community, 539 Beryllium beryllium dust, 675 disability from, 174 Blood vessels: pathology in chest diseases, 7 Books Airborne Contagion and A ir Hygiene (W ells), 564 Dust Is Dangerous (Da vies), Z27 Electroplating Engineering Handbook (Graham and Pinkerton, ids.), 365> Factors Affecting Goats of Hospital G uo (Hayes, ed.), 566 Financing Hospital Caro in the United S tates: VoL XL. Prepayment and the Communlty; VoL IIL For Nonwage and Low-In come Groups (Becker, ed.), 228 Books--Continued Hatogcnated Hydrocarbons; Toxicity and Potential Dangers (von Oettingcn), 369 Handbook of Emergency Toxicology (Kaye), 566 Handbook of Medical Treat ment; Ed, 4 (Chatton and others, eds,), 459 Human Element in Indus trial Accident Prevention (Larson and others), 370 Legal Medicine, Pathology and Toxicology, Ed. 2 (Gonzalez and o th ers),227 I-chrboch der Arbeitshygiane: Band I. AUgemeine Physiologic und Hygiene dcr Arbeit, Ed. 3 (Koclsch), 108 Mortality and Morbidity During London Fog of December, 1952; 564 Fncumokoniosen (W orth and Schiller), 45? Skin (A llen), 458 Staubhingenerkrankungeo: Band I I (J&tten and others, eds.), 227 Textbook of Healthful Liv ing, Ed. 5 (Diehl), 458 W orkmen's Compensation (Somers and Somers), 227 C Calcium silicate dust, hydrous: effect on animat tissues, 348 Carbon monoxide from pas senger ear engines, 678 ids ire are di os: tfed m). ocy 6 eat- and - Xustion 370 logy s ) fcaM dene :>- idity t of , 'orth mi: and U v58 mtioa >,227 j I 1 m s: sues. 4 I pas78 SUBJECT INDEX TO VOLUME 12 Carbon tetrachloride i Hver disease from, $22 Ceramics industry: silicosis control ui) 247 Chest diseases: See also lo n g s ; diseases by name; McIntyre-Saranac confer ence on, 1: papers read at, 1 ff , 109 ff,, 22? ff. Chlorine trifluoride: inhalation toxicology, 515 Cholinesterase: activity levels in normal subjects, 406 Chromium: reaction of com pounds with body tissues, 258 Coal mining: pulmonary dis ability from, 204 Cobalt '' effect on animal lungs, 116 oxide, biological action, 124 particulate metal, biological action, 127 Compensation, disability for pneumoconiosis, 159 Wisconsin Act, physicians and, 427 Correction, editorial: estima tion o f loss of visual effici ency, 527 D Deafness, occupational, 643 D eaths : Peterson, Carl M , 371 D u st: See also substances in volved air-borne, particle count. weight, shape, and rise, 361 control in metal mines, 167 differential susceptibility o animals to , 288 diseases In G reat Britain, 83 ridioactiTe, clearance from lung, 99 E Earths, rare i See Rare earths Edathamil cakmm-disodium: for lead poisoning, $28 Employee problems, 592 Employee sickness and health sendees, costs, 472 Fluorine compounds: Indus* trial uses and cutaneous reaction, 412 Fluoroscopes, time totalizer for, 573 F og: photomicrography of particles, 584 Foundry w orkers: silicosis control in, 221 Glass wool biological action, 280 effects on animal lungs, 276 Gold mining chest diseases in South Africa miners, 33 pneumoconiosis in K olar Gold Field, 73 . pulmonary disability legisla* tion in South Africa, 147 silicosis control in, 250 Great Britain dust diseases in, 83 silicosis in, 86 Guiana, British: health survey in mining community, 539 Gypsum calcined dust, biological ef fects, 329 dust effects on lungs, 209 Hands terminal phalanx contusions, hydrocortisone-neom ycin for, 388 cleaners, waterless, 572 Health examinations; periodic, 420 Hydrazine in air, determination of, 511 in blood, "p y rid y r te st for, 393 methylated derivatives, tox icity of vapors, 609 Hydrocortisone: with neo mycin, for terminal pha langeal contusions, 388 I India: pneumoconiosis in K olar Gold Field, 73 Iro n ; ductile, odor problem, 571 L Labeling program of Manu facturing Chemists' Asso ciation, 378 Lead absorption, urinary porphy rins in, 396 poisoning, caldura-dlsodhim for, 528 Legislation; pulmonary dis ' ability, of South Africa, 147 Liver disease: from industrial poisoning. 522 Lungs: See also diseases a f fecting, by nam e, sub stances injurious to, hy name ' biopsy, value of. 26 blood vessels in disease of, 7 clearance of radioactive dust from , 99 disability legislation of South Africa, 147 effects of rare metals, 116 M M cIntyre Research Founda tion,. 2 M clntyre-Saranae Conference on Occupational Chest Diseases, 1 papers read at, X f f , 109 ff,, 229 ff. Manufacturing Chemists' As sociation labeling pro gram , 378 Metals raining, dust control in, 167 rare, effects on animal lungs, 116 7 A. M. A. ARCHIVES OF INDUSTRIAL HEALTH Mines and mining coal mines: See Coal mining dust control in metal mines, 167 gold mines: Sec Gold min ing health survey in British Guiana mining community, 539 - radon problem in deep-level mining, 163 vanadium, 63S O ccupational H ealth N ew s --Continued Occupational Health Pro gram, advisory committee, 682 Pacific Northwest Industrial H ealth Conference, 688 phosphoric ad d (hot) poi soning, 582 plastics industry, hygiene problems, 470 platinum electrode, rotating, 581 N Naphthenic acids: and their metal salts, toxicity of, 477 Neomycin: w ith hydrocorti sone, for terminal phalanseal contusions, 389 N ews and Comment, 107, 226, 368,461, 642 ' N-Nitrosodimethylamine: tox icology of vapor, 617 Noisc< environmental, 569 radiation survey meter re sponse, $80 research grants in occupa tional health,- 576 solvents, 683; concentration from spray-painting. 569 standard for places of em ployment, 568 telling the story, 575 threshold limit values, 685 uranium mining, 7-state con ference, 465 vanadium d u st 675 O OCCUPATIONAL HEALTH News, 461. 567, 673 abrin, lethal jewelry, 468 a ir pollution: in Florida, 567} Public Health Serv ice community program , 462 beryllium dust, 675 Oxalic a d d : industrial uses and cutaneous reaction, 412 P . Parndichlorobenzene : liver disease from, 522 Petroleum industry: toxicity of naphthenic adds and their metal salts, 477 carbon monoxide from pas senger car engines, 678 dusts, organic, beryllium, and vanadium, 67$ employee sickness and health services, cost, 472 fluoroscopes, time totalizer for, 573 hand ekaners, waterless, 572 industry health plan, 567 iron, duetije, odor problem, 571 micropipette control, home made, 688 noise, environmental, $69 nursing fellowships, 687 occupational health "detec tiv e " 673 Phusphoric a d d (hot) : poi soning, 582 Photomicrography: of air borne particles, 584 Plastics industry, hygiene prob lems, 470 Platinum electrode, rotating, 581 Pneumoconiosis compensation, evaluation of, 159 dust diseases in Great Britain, 83 in K olar Gold Field, 73 talc, 66 Porphyrinst urinary, jq lead absorption, 396 Postgraduate education, 226, 476 Potassium : antagonistic action of $O, 109 '`PyrldyP' test, for blood hy drazine, 393 Q Quartz antagonistic action of K*CO, 109 dost, surface properties: bio chemical, 262; cytobiologkal, 266 R Radiation from barium sulfate dust, 628 clearance of radioactive dust from hmg, 99 estimating Curie content of packaged radioactive wastes, 383 radon: See Radon survey m eter response, 580 Radium-dial industry: external radiation exposure In, 503 Radon acute toxicity of, 435 problem of, in deep-level mining, 163 Rare earths biological action, 301, 306 effects on animal lungs, 297 S Saranac Laboratory, 4 Silicosis ' aluminum prophylaxis and therapy in ceramics Indus try, 247; experimental, 229; in foundry, 221; in gold mining, 250 antagonistic action of SiCh and K & O * 109 . . in Canada, 56, 63 control, in gold mining, 250 epidemiologic Study in U . S., 48 in gold miners of South Africa, 33 I SVBEC * Sllicosis- ' in Gres i pulmn ' tlon i Society n Seal j Solvents, compos 623 concent palm general posit 509 Sonth Ai ehest d in, pnlmor tian, Talc dust,e 317 TH 226, j :o* Mo tto . itili, that it of tire 580 T rai .503 SUBJECT INDEX TO VOLUME 12 Silicons--Continued Talc--Continued Uranium Mining--Continued in Great Britain, 86 pulmonary disability legisla tion in South Africa, 147 mining dust inhalation ef fects, 182 pneumoconiosis, 66 radon problem, 163 radon toxicity, 435 Society new s; American Med ical Association, 642 Solvents, 683 composite, toxicity of vapor, 623 concentration from spray painting, 569 generating vapor with com position of parent solvent, 509 South Africa, Union of chest diseases in gold miners fa, 33 pulmonary disability legisla tion, 147 T... Talc dust, effects on animal tissue, 317 Tantalum oxide biological action, 121 effect on animal lungs, 116 ThiopKospbitca: toxicologic studies on trim ethyl- and triethyltritiuophosphites, 483 Tungsten carbide and carbon; bio logical action, 137; effects on animal lungs, 116 carbide and cobalt; bio logical action, 140; effects on animal lungs, 116 effects on animal lungs, 116 particulate metal, biological action, 134 U Uranium mining on Colorado Plateau, 375 V Vanadium dust, 675 Vanadium ore : health of workers with, 635 Vanadium toxicology; finger nail cystine fa, 494 V apor toxicity; See also sub stances involved of composite solvent, 623 generating vapor w ith com position of parent solvent, 509 V ision; estimation of loss of visual efficiency, 439, 527 W Wisconsin W orkmen's Com pensation A ct; physicians and, 427 306 ,297 and in s. total, t ; fa S iO . ; 250 xs. 90Qtn li' ) OCCUPATIONAL CANCER HAZARDS IN AMERICAN INDUSTRIES W. C. HUEPER, M.D. BETHESDA, MD. MOD ERN industry has brought along a considerable number and variety of carcinogenic agents and, no doubt, will bring ever new ones as it develops new methods of production and new products and applies established methods and agents to new purposes. If we look at the long and ever-growing list of known and suspected occupational carcinogenic agents, if we contemplate their widespread existence as industrial wastes contaminating air,*1 water, and soil of the wastedisposal areas of industries, if we consider their presence in many products of daily consumption, we have the general spectrum of the cancer hazards which originate from our modern industrial development. Control measures must be based on the realization of this wide potential scope of carcinogenic contacts. They must con cern not only workers engaged in the production or the use of carcinogenic agents but also the population living in the environment of plants with carcinogenic hazards, as well as the general public.2 It is well to remember that experience with occupational cancer has demonstrated that, given a carcinogenic agent and proper conditions of exposure, the occurrence of cancer among the exposed individuals is merely a question of time. The incidence rate and the length of the latent period depend mainly on the relative potency of the carcinogenic agent present and the intensity of the exposure. The lack of adequate epidemiologic studies and the usually long latent period of exogenous cancer often obscure the appreciation of causal relations between occupational factors and cancer. . A few illustrations as to the distribution of exogenous carcinogenic hazards of industrial origin may be appropriate. For instance, men engaged in the mining and smelting of copper, zinc, and silver ores are exposed to arsenicals. The makers and users of arsenical pesticides that are employed in the form of sprays or dusts suffer a similar exposure, as do patients who receive arsenical medication. Beyond these rather narrow circles of producers and consumers of arsenicals stands that appre ciable part of the general population that comes in direct or indirect contact with arsenicals released into the atmosphere with smelter flue dusts or as a result of From the National Cancer Institute. Address presented at a meeting of the Cancer Prevention Committee in New York on June IS, 1949. . Dr. Hueper is Chief, Cancerigenic Studies Section, Cancer Control Branch, National Insti tutes of Health, Public Health Service, Federal Security Agency. 1. Hartwell, J. L.: Survey of Compounds Which Have Been Tested for Carcinogenic Activity, U. S. Public Health Service, 1941. (371 pp.) 2. Hueper, W. C.: Environmental and Occupational Cancer, U. S. Public- Health Reports 1948, Supplement 209. (68 pp.). . . 204 HUEPER--OCCUPATIONAL CANCER HAZARDS 205 large-scale dusting of orchards and cotton fields or from the use of sprays in truck gardens. Arsenicals may enter the human body in drinking water that passed as rain water through arsenic-containing slag heaps of smelters. The consumption of fruits, fruit juices, and wines contaminated with arsenical insecticides affords another source. In the field of organic chemistry we meet with bladder cancers among pro ducers and handlers of certain aromatic amines, and find that some of these amines are used in the manufacture of pharmaceuticals and that their derivatives are employed as flotation agents in the mining industry and as antioxidants in the manufacture of rubber. Finally, dust and fumes from aromatic-amine operations that have been improperly conducted as to exhaust ventilation may endanger not only workers in adjacent operations but also th population living in the fume zone of the plant. A similar environmental contact with vaporized aromatic amines may result from the burning of emptied containers on open lots within populated areas. Carcinogenic soot or tar fumes cause cancer of the lungs and skin not only in stokers of coke ovens but also in makers of products for which heated tar and asphalt are used, for example tar paper and asphalt shingles. The possibility must be considered that carcinogenic hydrocarbons of industrial origin may cover as a film the extremely small particles of flue dust and exhausts of petroleum-cracking units. The question has been raised whether a similar hazard exists in concrete factories in which soot-producing diesel engines are used. Carcinogenic soot may also be released into the atmosphere during the manufacture and industrial use of carbon black obtained from oil residues or natural gas or from the burning of waste oils near refineries, causing an occupational and environmental hazard. Carcino genic oil and tar dusts from oiled or tarred roads present a potential hazard, involv ing the general population. Similar considerations apply to other carcinogens, such as metallic and radioactive ores. The recognition of carcinogenic agents and exposures is a prerequisite to a rational and intelligent occupational cancer control. Epidemiologic surveys of plant populations are very important in this respect. Exogenous occupational carcinogens not only excessively increase the cancer incidence rate of one particular organ but may elevate the total cancer incidence rate and primary cancer multiplicity. Like wise, not only workers exposed to aromatic amines show a high liability to bladder uicer, but also workers in gas plants. Thus, specific cancer sites are not neces sarily indicative of any particular type of carcinogenic agent. Several agents may exert synergistic action when acting simultaneously or successively, or may independently produce cancer at a certain site. It may be worth while mentioning here that leukemia may result from lowlevel, prolonged, and diffuse exposure to x-rays, radioactive agents, or benzol. Nasal sinus cancers have been observed in men exposed to a volatile nickel com pound (nickel carbonyl) in the course of nickel refining. Lung cancers have been observed in chromate workers. The use of metals in abrasives and as catalysts in the organic chemical and the petroleum industries as well as the production of metal dusts and mists or vapors in welding, spraying, and polishing operations and in the production of alloys from metal powders may greatly extend the potential scope of occupational metal cancers and may introduce occupational cancer hazards where these are not readily suspected. 206 INDUSTRIAL HYGIENE AND OCCUPATIONAL MEDICINE One of the most important attributes of many exogenous carcinogens is their ambivalent properties; i. e., depending on the intensity of action or the dose, they may produce manifestations either in the degenerative, necrotizing, aplasiogenic range or in the hyperplastic, canceroid, leukemoid, cancerous range. In studying a worker population for the presence of a carcinogenic agent, a wide range of abnormal symptoms may be noted representing a diagnostically significant syn drome which I have termed the environmental-carcinogen pattern. Thus, an individual who develops an occupational carcinoma may exhibit not only various types, of proliferative, precancerous reactions but, preceding or accompanying these hyperplastic reactions, manifestations which are of the degenerative, atrophic, ' necrotizing type. Likewise, various members of a worker population exposed to the same carcinogenic agent at different dose levels may display abnormal reactions representing the entire scale of the environmental-carcinogen pattern. Thus, in a benzol operation some workers may suffer from aplastic anemia, others from moderate anemia and leucopenia, a third group may display hyperleucocytosis and polycythemia, while still others may have leukemoid and leukemic reactions. A similar hematic syndrome may be seen in persons exposed to x-rays. Whenever a plant physician observes even parts of such environmental-cancer patterns, he should become alerted to the possibility of a carcinogenic hazard in the operation in which the affected workers are employed. Other important clues in this respect may be obtained from the demonstration of excessive incidence of cancer in special groups of workers and also from shifts of the sex ratio of cancer incidence. For instance, the male-female ratio of lung cancer incidence is approximately 5:1. Merewether recently reported 31 cancers of the lung associated with asbestosis in a series of 235 cases of asbestosis. There was not only an excessive lung cancer incidence in this group (13.2%), but the male-to-female sex ratio of the cancer cases stood at 2:1. The histologic type of cancer is as a rule of no significance as a clue concerning an occupational or a nonoccupational origin. However, in the case of lung cancers it appears as if an increasing preponderance of squamous cell and anaplastic cancers over adenocarcinomas favors an occupational or exogenous origin or per haps more exactly reflects the action of a respiratory carcinogen. Thus, shifts in the ratio of squamous cell cancers to adenocarcinomas of the lung may have an etiologic significance and may indicate not only that an occupational carcinogen is present in a particular operation but that the injurious agent occurs in the form of a gas, vapor, mist, dust, or fume. It is not likely, on the other hand, that the inhalation of dust or mists might elicit cancers in the nasal sinuses, because the narrow passages leading to these cavities would prevent matter of relatively large particle size penetrating into these cavities. However, gases, vapors, fumes, and colloidal dust of carcinogenic property might enter the nasal sinuses. It is obvious not only that the various types of information mentioned are essential for the discovery of an occupational cancer hazard and for the identifi cation of the causative agent but that they are of utmost importance for the . subsequent development of effective preventive and precautionary measures. The acquisition of these data thus forms a part of any sound control program and in fact represents the foundation of it. HUEPER--OCCUPATIONAL CANCER HAZARDS 207 . While it is not possible to discuss here the full scale of control measures that might or should be applied in the numerous and different carcinogenic operations, it may be advantageous to present general directives and a few specially important considerations. Since we do not know the minimal effective dose of any of the many occupa tional carcinogens, it seems obvious that they should be completely eliminated wherever that is practical. This can be done by using or producing suitable non carcinogenic substitutes; ft is usually feasible without creating serious production difficulties to replace benzol by other organic solvents having similar effectiveness. In the case of the highly hazardous beta-naphthylamine it is possible to eliminate the hazard by starting with a sulfonated beta-naphthol which is later aminated and . which in a sulfonated form is not carcinogenic. A closed system of production in which all hazardous phases are carried out is another effective method of elimi nating cancer hazards in industry. Wherever bulky material is handled, the adoption of a closed system of production may be difficult. Then other means must be found to eliminate or considerably reduce the carcinogenic hazard. The goal may some times be obtained by changing from a dry method having a dust hazard to a wet method. Good housekeeping in plants and personal hygiene of the workers are other ways to reduce hazards. Good exhaust ventilation is essential wherever dust, fume, vapor, mist, or gas hazards exist. However, care should be taken that the carcinogenic material is removed from the exhaust air before the wastes are released into the atmosphere and that none of such wastes are blown into adjacent working places and living quarters. Many of the more recently constructed indus trial plants are built in such a way that the machinery stands either free or in an open-air shelter, so that any injurious gases, fumes, or vapors may be readily dispersed into the surrounding atmosph&re and thereby become harmless through dilution. While such a system may be suitable for some carcinogenic hazards, it seems to be unsuitable for others, especially for those which are due to agents that are not readily decomposed but accumulate on the ground and in the water and thus may gradually reach dangerous concentrations. In instances in which the carcinogenic factor represents only a very small portion of the entire product, as in tar, pitch, petroleum derivatives, and similar products, an attempt should be made to develop either production methods through which the production of carcinogenic contaminants is avoided, or, when this is not possible, to remove or destroy the carcinogenic portion in the hazardous product. Until such measures have been developed other procedures are being utilized. In the case of carcinogenic oils or tars, these procedures consist in diluting the oil or tar with noncarcinogenic material so that the carcinogenic potency is lost or reduced to such a.low degree that any potential cancer resulting from prolonged and repeated contact with such products has a latent period surpassing the average life span of man. While such engineering and technical measures are of utmost importance in the control of occupational cancer, the intelligent and ready cooperation of the workers in observing additional precautionary measures when handling cardnogenic material should be obtained. Unless the handlers are informed of the hazards connected with their work, they cannot be expected to follow rules and regulations ' issued by management. Only when they know and realize the potential risks which f ) 208 INDUSTRIAL HYGIENE AND OCCUPATIONAL MEDICINE carelessness may entail, can they be expected to cooperate intelligently. It seems only fair to industrial users and the general public that a reasonable amount of information about the existence and types of occupational carcinogens is made available to them, so that such hazards cannot be spread or sustained any longer by sheer ignorance of such matters. This does not imply that such information has to make headlines in newspapers, but in a quiet way, preferably, through trade circles, pertinent data on recognized, suspected, and potential carcinogenic agents should be distributed, so that the necessary technical and commercial adjustment processes can be initiated and carried out in an orderly fashion without causing any serious disruptions in the industrial, economic, and social pattern. Without any doubt, a great deal of educational work has to be done in medical circles so that the members of the medical profession become aware of the existence of occupational cancer hazards and learn to discover and evaluate properly pre cancerous conditions and thereby aid industrial management in controlling occu pational canceration effectively from a medical standpoint. While medical efforts are not likely to reduce in any fundamental fashion existing cancerigenic conditions in industrial plants, they can contribute definitely in alleviating the prognosis of the unfortunate victims. While much evidently remains to be done in controlling occupational cancer hazards, I do not believe that mankind will succeed in eliminating them completely. As little as this result was obtained in connection with contagious diseases, all of which to some degree are still with us, so will our best efforts fail of entirely eradicating occupational cancers. These will remain with us as manifestations of our self-created modern industrial environment from which we are unable to escape and which we can modify only within certain limits. Though cancer is one of the risks of living, we doubtless shall succeed in reducing these risks to a considerable degree, particularly where they are excessive, for occupational-industrial reasons. ' (The two works referred to in Footnotes 1 and 2 are available at a cost of $1 and of 20 cents, respectively, -from the Superintendent of Documents, U. S. Government Printing Office, Washington 25, D. C.) ABSTRACT OF DISCUSSION The question was raised as to the feasibility of avoiding the betanaphthylamine hazard by sulfonatioa Dr. Hueper stated that the use of sulfonated beta-naphthol as a starting material is a process developed in Switzerland.* It has not as yet been employed in the United States. Pr. Hueper also stated that he had noted the use of alpha-naphthylamine in the preparation of pharmaceuticals. He pointed out that commercial alpha-naphthylamine always contains some beta-naphthylamine, which apparently has been responsible for the occurrence of bladder cancer among alpha-naphthylamine producers. Radioactive materials were considered with reference to the need of long-range planning . for disposal of radioactive wastes. The problem of latency was discussed. Dr. Hueper stated that the latent period of tumors induced by the following materials increases in the order shown: tar, pitch, shale oil, petroleum. It was the consensus that the employment of elderly rather than young persons should be recommended for tasks involving uncontrolled carcinogenic hazards. The view was that the life span of elderly workers would run out before cancer could be induced by the materials to which they were exposed, 3. Muller, A.: Ueber Blasen- und Nierenschadigungen in der Farbstoffindustrie, Helvet. chir. acta 18:1-41, 1951. .