Document daBDdRdKyypb6LQ1Lq7q08r6
C-- 17-1?
Submitted to:
BICSEARCH,
1!,IC.
p.o. box 8598 philadelph'a,pennsylvania 19101
t e Ie p h o n e (2 15 ) 8 4 8 -4 4 9 9
Project Number 77-1127A
3M Company 3M Center
St. Paul, Minnesota 55101
Material: Sample Received: Date of Report: Test: Object of Test: Method of Test:
Results:
3M Company - T-200ICoC
11/21/77Study Initiated: 11/30/77Study Completed: Ii/6/77
1/6/78
Primary Eye Irritation Study - Rabbits
To determine the degree of irritation, if any, which the subject material may produce when instilled into the eyes of albino rabbits.
The methods employed in the testing, evaluation and in the grading of the test material are those described in Section 1500.42 - Hazardous Substances and Articles, Administration and Enforcement Regula-
tions, Federal Register, V.)I.38. No. 187,P. 27019, 27 September 1973.--
The sample was used as supplied.
Six healthy young adult albino rabbits were used in this study. 0.1 mi of the experimental material was instilled into the right eyes of the test animals while the other eyes remained untreated to serve as controls. The test material was not washed from the eyes.
The treated eyes were examined at 1, 24, 48 & 72 hrs. 5 & 7 days following instillation of the test mater.ial
into the eyes. Interpretationof the results was made in accordance with the grading system outlined in the "Illustrated Guide for Grading Eye Irritation By Hazardous Substances".
See Table 1.
3M Company - T-200lCoC, Primary Eye Irritation Study.
Conclusion:
Based on the accompanying table, the subject
material is not a primary ocular Irritant within the definition of the Act-Reference: Section 1500.42 (b) (1) (2) P. 27019 and requires no cautionary labeling with respect to that section.
Karl L. Gabriel, V.M.D., Ph.D. Director
TABLE I Grades for Ocular Lesions
.'Iatet-i.ii3:M Company
1 hour
24 hours
Rabbit No.
1 2
3 4 5 6
1
2
3 4 5
6
48 hours
3
4
5
6
1
2
72 hours
3
4
5 6
1
2
5 days
3
4
5
6
1
2
7 days
3
4
5
6
T-2001COC, as supplied.
Cornea
Opacit
Area
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
Iris
Conjunct;vae
Rcdness Chenios is
0
1
1
0
2
a
0
2
0
2
2
0
1
2
0
0
0
0
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
.0
0
a
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
a
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
a
0
0
0
0
D ischa ae
3 3
3
2
3
0
1
0 0 0
0
0 0 0 0 0 0
0 0 0
0 0 0
0
0
0 0 0
0
0 0 0
0 0
0