Document dYwggr4armEQvgwXgYGNYE1gG

RICHARD D. G R E E N F IE L D * N IC H O LA S E. C H IM IC L E S C. O LIV E R B U RT, III KENNETH A. JACOBSEN R, BRUCE MCNEW BRENDA M. NELSON PAMELA S. TIK E LLIS MICHAEL J . P U C IL L O " KEVIN M. P R O N G A Y 0* JU D IT H N. DEAN, O F C O UN SEL MICHAEL J . BONI MICHAEL D. DO NO VA N* FRANCIS J . FA RINA * BARBARA M. FRIEND^ J. PAULGJGNAC*" MICHAEL D. G O TTSC H * PATRICK J . G R A N N A N " CAROLYN D. MACK JA M E S R. M ALO NE , JR. MARY KATHERINE MEERMANS DEBRA N. N A T H A N S O N * * TINA BAILER N IE V E S ROBIN RESNICK CHRISTOPHER T . REYNA IRA N E IL R IC H A R D S * MARK C. RIFKIN MILES B. RITTM ASTER O L IS A J. RODRIGUEZ* STEVEN A. SCHWARTZ DENISE DAVIS SC HW ARTZM AN** EDWARD SEGLIAS x * JEFFREY T. SPANGLER J. DAVID STONER" JAMES C. STRUM A WENDY ZOBERMAN** Gr e e n f ie l d &Ch imic l e s At t o r n e y s a t La w One Ha v er f o r d Cent r e 361 West La n c a st er Av en u e, P.O. Box io o Ha v er f o r d , PA 19041-0100 (215) 642-8500 Tel ec o pier : (215) 649-3633 Ca bl e: "WHITEHAT" Ph il a d el ph ia June 21, 1991 VIA FEDERAL EXPRESS Neil T. Leifer, Esq. THORNTON & EARLY 200 Portland Street Boston, Mass. 02114 O n e Ro d n e y Sq u a r e P.O. B o x 1 035 Wil m i n g t o n , DE 1 9 6 9 9 (302) 6 5 6 -2 5 0 0 TELECOPIER: (3 0 2) 6 5 6 -9 0 5 3 O n e Ca l if o r n ia Pl a z a 3 0 0 So u t h Gr a n d Av e n u e Los A n g e l e s , CA 9 0 0 7 1 (213) 6 2 6 -6 1 0 0 TELECOPIER: (213) 6 2 6 -7 9 0 1 ESPERANTE 222 La k e v ie w Av e n u e . Su it e 9 6 0 We s t Pa l m B e a c h , Fl o r i d a 3 3 4 0 1 (407) 8 3 5 *9 4 0 0 TELECOPIER: (4 0 7 ) 8 3 5 -0 3 2 2 * A L S O A DM ITTED T O NY BAR a l s o a d m it t e d t o c a a n d d e b a r s E a l s o a d m it t e d t o o c b a r (a l s o a d m it t e d t o n j b a r A L S O ADM ITTEO t o DC AN D NY BARS 0 ADMITTED t o NY BAR ONLY ^A D M IT T E D T O DE BAR O NLY * ALSO ADMITTEO TO NY AND NJ BARS A L S O ADM ITTED T O NY, N J AND IN BARS * * ALSO ADMITTED TO C A BAR ADM ITTED TO F L BAR ONLY " A L S O ADM ITTED TO F L DC AND T X BARS "ADMITTED TO CA BAR ONLY * * A L S O AOMITTED T O OE BAR ^ A D M IT T E D T O CA. NY AN D N J BARS ONLY Re: Lead Paint Liticration/Kehoe Documents Dear Neil: , Enclosed is the first installment of documents that we selected from Robert Kehoe's papers in Cincinnati. We are expecting others to be copied and sent to us from Cincinnati with the next few weeks. We also plan to return to Cincinnati to complete the review some this summer. We will continue to send you copies of the documents we select, as well as our index and analysis of the documents when they are available. If you have any questions about these documents, please contact Miles Rittmaster of our office who is conducting the document review. Best wishes Sincerely, MKM/as Enclosures - M. ne Meermans 2uu! CP cs .<*j EXPERIMENTAL WORKINPROGRESS in THEKETTERINGLABORATORY Tlie general workof the Laboratory includes the clinical study of specific patients suffering fromdiseases suspected of being occupational inorigin. Sometimes this turns out to be true - sometimes untrue. Some of the work relates also to the investigation of occupational problems in industrial plants, where trouble or the threat of trouble has developed in relation to general or specific hazards. The members of the staff are occupied most of the time, however, in investigations of the nature andextent of the hazards posed by the use in industry of old or newchemical substances or mixtures of substances in 4 old or newindustrial processes. The large proportion of tShese problems, t~ > like those that relate to specific patients and specific industrial plants, , cannot be publicized. That is, they are the medical problems - the illnesses andthe threatened illnesses - of people, whose relationship withthe staff of this Laboratory are like those of private patients with physicians. If ' at these matters are referred tcyall in publications, they must be dealt with in general terms. Ingeneral, we avoid the discussion of specific investigations outside the Laboratory. Certain problems, however, which are nowandhave been under investigation for a long time, the results of whichhave broad applications ina number of industries,can be referred to. 1. One of these relates to the systematic investigation of the behavior x of lead compounds in the animal organism inhealth anddisease. Sometime ago a series of lengthy experiments onthe fate of lead ingested with food by 2. human subjects were completed after some ten years of careful investigation. Somewhat similar experiments were then initiated wherein the fate of lead in finely dividedform inthe atmosphere inhaled byhuman subjects was investi gated. These experiments have been in progress since 1950. They cannot be completed before I960 at the earliest. This work serves to elucidate the physiological mechanisms for the handling of lead compounds inthe human body, and, inaddition,will provide the background of information onwhich standards of safety in relation to human exposure to lead canbe established with precision. Such standards are neededfor the purposes of industrial safety as well as those of public health. The effort to obtainbasic and comprehensive information on the physiologic andhygienic aspects of this metal and its compounds has beeno+ne of the major ac'tivities of this Laboratory since it was.foundyed in 1930. This workbegan in the Physiology Department of the Medical School in 1925. 2. Asecond major experimental problemin which the Laborator been engagedfor many years is that of the behavior of the inorganic compounds of fluorine (andalso some of the organic compounds of fluorine) in the animal organism. This problem relates to the health of industrial employees, primarily, but it also extends into the general community in a number of ways, of whichthe most obvious example is that of the additionof inorganic fluoride to communitywater supplies for the purpose of combatting dental caries by effects exerted principally, but not exclusively, during the early years of childhood. y The workonfluoride has concerned itself primarily with the establish ment of the mechanisms inthe humanbodyfor handling fluorides. Like lead, 3. fluoride is a normal and inevitable constituent of the human dietary, so that it is found inall food andin all humantissues inlow concentration. Illness may result fromthe absorption of excessive quantities of fluoride, and the purpose of the investigation has been mainly to establish clearly the limits which distinguish between normal, safe andhazardous absorption of fluoride. Again, as inthe case of lead, standards for industrial andpublic safety are required, in terms of the quantities of fluoride that may gain entrance into the humanbody by way of ingestion infood andwater, andbyway of inhalation from the atmosphere. 3. Athird field of long-term investigation has involved the study various aspects of the general problemof atmospheric pollution. These investigations, initiated prior to 1940, have concerned themselves with the detection andthe quantitative measurement of many of the contaminants of the atmosphere in various parts of the United States. The most comprehen sive observation have been carried out in Cincinnati, but a score of other industrial centers have been included inleas extensive analytical surveys. One such survey, completed only recently under the financial sponsorship of the American Petroleum Institute, concerned itself withthe concentrations of ozone andthe oxides of nitrogen in a number of American cities. These substances inthe atmosphere appear to be important components of the systemof contaminants of the atmosphere in Los Angeles which react with each other, under appropriate conditions, to yield a compound (perhaps compounds) capable of causing stinging andburning of the eyes with weeping (a lacrimator or a "tear gas'.'). The "Preventive Medicine component" of the Department of Preven- 4. tive Medicine and Industrial Health, of which the Kettering Laboratory is the 'Industrial Health component," is engaged, with some assistance fromthe Laboratory, in afairly extensive effort to develop methods for the investigation of the human response to air pollution. That is, to determine means whereby the effects of air pollutionon humanhealth can be detected andmeasured. This extension and elaboration of the work of the Laboratory inthis field, lias beenfinanced for the past three years byfunds fromthe Division of Grants of the United States Public Health Service. 4. Still another problemof importance to industry inwhichthe Laboratoryhas been active for some years, andwill continue to workfor years to come, is that of occupational cancer. Afairly elaborate programof investigation of the potential hazard of cancer of the skin in the petroleum s industry was initiated under the financial sponsorship of the American Petroleum Industry several years ago. This work was extended to include the coal tar industry in 1954, bymeans of funds supplied by a group of manufacturers anddistributors of coal tar. The concern of the industrial sponsors of these investigations has not been aroused by the outbreak ofs malignant tumors of the skinamong the employees in these industries, but rather by the potentialities which reside in the cancer-inducing substances s ., in petroleumand coal tar andin certain of the products of these industries. There is need to knowwhether these substances are exerting an influence uponthe health of industrial employees, andwhether preventive measures of one kindor another should be developed and applied. The purpose of these investigations, therefore, is primarily one of fact-finding, and secondarily one of preventive medicine. 05 6* 4 Other types of occupational cancer and inparticular, lung cancer, is so far as it may atomfromspecific factors inthe industrial environment are the subject of interest among the groupof investigators whohave been assembled at the Laboratoryfor the investigationof cancer. Some funds are available fromindustrial sources in support of investigative workalong this line andothers are being sought. 5. Inaddition to the foregoing series of long terminvestigations w serve as a firmnucleus for the general work of the Laboratory, a continual streamof industrial products - solvents, insecticides, plastics - are subjected to preliminary, brief or more elaborate toxicological investigation, in accordance withthe practical needs of the situation. Some of these materials find immediate use, while some are under consideration for uses in which their potentialities for harmto people who may handle or use themare factors to be considered. /