Document dYrxE3KzxxbqJoj1E6ZJ5wDke

Rats inhaling benzene [71-43-2] or carbon tetrachloride [56-23-5] vapors at various cor.cns. showed a no. of abnormalities in NERVE-MUSCLE FUNCTION, blood cell compn., and in body wt. and internal organ wt. These symptoms were intensified and new symptoms appeared when the poisoned animals were stressed by bleeding or by administration of ethanol [84-17-5]. ^ J473H Pathogenesis of changes caused by long-term \ exposure to vinylchloride. Basalaev, A. V.; Bazin, A. N.; 1 Kochetkov, a7Tj\ (Med. Inst. im. Kirova, Gorki, USSR). Gig. 1 Tr. Prof. Zabol. 1972, 16(2), 24-7 (Russ). Rats and rabbits M inhaling vinyl chloride [75-01-4] fumes at 0.03-0.04 mg/1. 4 hr a I day for 6 months showed changes in the bioelec, activity of the J hypothalamus, hyperadrenalinemia, resorption of bone tissue, / osteoporosis, and disturbances in the cardiovascular system. The TOXIC SYMPTOMS were apparently caused by abnormal functioning of the hypothalamus. 1474j Excretion of 2,4-dinitrophenol and 2-amino-4-nitrop= henol. Senczuk, Witold; Baer, Wanda; Mlynarczyk, Wieslaw (Inst. Chem. Anal., Akad. Med., Poznan, Pol.). Bromatol. Chem. Toksykol. 1971, 4(4), 453-60 (Pol). A dose-dependent CH JL ^ N02 R&S 025180 no2 I urinary excretion of 2,4-dinitrophenol (I) [51-28-5] and 2-amino-4-nitrophenol [99-57-0] was obsd. after orally treating rats with I (1.5-12 mg/kg). Repeated administration of 3-mg doses of I had no effect on the rate of excretion. I and its metabolite, after extn. from urine samples with ethanol, were paper-chromatographed and then detd. spectrcphotometrically at < ' * .1