Document dYnR4ENbLDDQ2Q5w2QqyNLvVq

AR226-1383 <FRCUECT CONTROL >: S7 \ (INVESTIGATOR): UEF (SPONSORING DEPD: FfO OEfiJtlAEJ3BJEIiyESii tl. TO DETERMINE U)ETHER PREGNANCY OLTTCOfC ttlNG FEMALE UW EMPLOYEES IS CAUSALLY RELATED TO THEIR OCCUPATIONAL EXPOSURE TO C-3. DMF. OR HFA. (2). TO DETERMIIC IKTHER PREGNANCY OUTCOfE AMONG WIVES OF UU EMPLOYEES IS CAUSALLY RELATED TO THEIR HUSBANDS' EXPOSURE TO C-8, DMF. OR HFA. GIliOX-DESiaOL LOCATION: WASHINGTON WORKS TYPE OF STUDY: CROSS-SECTIONAL. STUDY GROUP: ALL MALE AND FEMALE ACTIVE EiffLOYEES AT PLANT; WIVES OF )VL EMPLOYEES. REFERENT GROUP: COMPARISONS BETWEEN EXPOSED AND NGN-EXPOSED WW EMPLOYEES. SPOUSES; COMPARISONS WITH ANOTHER DU PONT PLANT. EXPOSURE DEFINITION: C-8. DMF. PFA; WORK AREA (TEFLON AREA ESPECIALLYI. BLOOD ORGANIC FLUORIDE LEVELS. DATA SOURCES: SELF-ADMINISTERED QUESTIONNAIRES; PERSONNEL RECORDS (WORK HISTORY). OUTCOME VARIABLES: PREGNANCY OUTCXft (EG., ABNORMALITIES IN TIE NEWBORN. ETC.) 04/13/81: 04/15/31: 04/14/81: 04/23/81: 05/08/81: 05/15/81: 04/12/81*. 07/22/81: GIAIUS-OE-ESOJECDl STUDY PROPOSAL WRITTEN AND CIRCULATED AMONG MEDICAL OIV AND PPD. QUESTIOWAIRE DRAFTED. QUESTIONNAIRE APPROVED BY BUK/BNC. MEETING WITH MEDICAL AND PPD (SERENBETZ. RAINES, IICO, IRSCH, NACE, INGALLS, CULPEPPER, FAYERWEATVER). (EET1NG WITH MEDICAL AND PPD (HES. JWR. NJI, ROl, BUK. WEF). UU PREGNANCIES BY YEAR AND PAYaASS PRESENTED*. SAiffLE SIZES FOR STATISTICAL SIGNIFICANCE FRESENTED*. ABNORMAL PREGNANCY CUTCCIE RATES WERE CALCULATED FOR ENTIRE COMPANY, 1979-1980. INFORfED CONSENT AND COffIDENTIALITY OF DATA PACKAGE WERE SENT TO BUK RD INGALLS SUBMITTED PREGNANCY OUTCOME COMMUNICATION PACKAGE TO IRSCH 'FOR ACTION.* UEF OBJECTED TO PACKAGE, SINCE IT INCLUDED A QUESTIONNAIRE THAT HAD NOT BEEN DISCUSSED OR APPROVED BY MEDICAL. THIS OBJECTION WAS BROUGHT TO TIE ATTENTION OF INGALLS, KARRH, m IRSCH. MEETING UITH IEDICAL AM) PPD (HES. BUC. SP.JJG.WEF); )ES SAID THAT STUDY UAS `ON HOLD* UNTIL FTJRDER NOTICE. DATES (HONTH/DAY/YEAR: DATE PROPOSED ... 4/ 4/81 EST COMPLETION DATE ... 0/ 0 / 0 DATE UORK APFROV ... 0/ 0/ 0 DATE UORK COMPLETED ... 0/ 0/ 0 _ 1383 BR000086 EIDI02437 000144