Document dYRXjgoZnqyo2YLED6MMNJ4RQ

The University of Nebraska -Lincoln Department of Chemistry Lincoln, NE 68588 402-472-3501 November 2, 1981 Dr. G ilb e rt Bogen V e tli ne-Hotli ne P.0. Box 216 Highland Park, IL 60035 Dear Dr. Bogen: Thank you for your l e t t e r o f October 23. I have sent a copy to Barclay Shepard of the USVA (see enclosed copy of le tte r to him). The idea of punch biopsy samples may be workable. In f act, we were going to tr y using samples troifTworkers in the~Nitro, West V ir g in ia plant, but_ Support from bPA_has f a l t e r e d. A research project is~ne^rted~tcrvalidate~ the'small"sampTe scheme before beginning. The minimum cost o f a project involving 100 samples inc lu d in g controls would be $52,000. That assumes the method involves large fat samples or has been validated fo r the small sample s iz e s (needle biopsy). Professor The University of Nebraska-Lincoln The University of Nebraska at Omaha The University of Nebraska Medical Center