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CONFIDENTIAL
August 28, 1992
WY.AL.SPHOIWNEGRT,ONM.WD.ORKS * POLYMERS
WASHINGTON WORKS - SURVEILLANCE DATA
MORAT ND CA ANL CERI INCT IDEY NCE
A`ssurrveeqiuleasntceedf,oart1a9c5h6a-1d9f8o9rWaansdhmionngttaoltnyWsourrvkesiallraencreesfuolrt1so95f7c-a1n9c9e1.r iTnhceisdeendcatea. are generated from Du Port's Company-wide epidemiologic survellance program. Tdoesacsrsiipsttiionnyoofutrheinmteetrphroedtaotlioognyanudseevda.luaAtcicoonmopfatnhyeifnigndtihnegss,urIvveeiilniacnlcuedteadblaes is a `summary of the major findings. Hfthes findings inciude a statistically significant `excass(os), futher folow-up may be recommended.
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INTERPRETATION OF EPIDEMIOLOGIC SURVEILLANCE DATA
Enciosedaretablesfor your site showing (1) cancer incidence surveilance from t1h9r5o6utghhro1u9g8h1 1a9m8o9nagmaoctnigveaectmipvleoeymepelsoyaenedspaennsdio(n2)ermso.rtFaolrtyssaucrhvesiplelcainfciecfrcaoumse1,8t5h7e numberof observed cases/deaths (OBS) is compared to the number expected (EXP) based on the experienceofthe entire Company. Comparison is madebytheratioof the observedtothe expected numbers of cases/deaths (OBS/EXP). Accompanying each table is descriptive text which summarizes the major findings.
Soouf SurrveicllaneceDasta
Since 1956,cancercasesthatocouramongactiveemployeesIntheUSS.are
recordedInthe Du Pont Cancer Registry. Through 1988, cases have been reported
tothe Registry primarlly by diagnoses entered on Accident and Health Insurance
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used to ascertain diagnoses of cancer among active employees. Beginning in 1977,
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Deathsthatoccuramong active and pensioned employeesinthe U.S. are recorded inthe Du Pont Mortality Registry thatwas initiated in 1557. Deaths are identiied througn fe insurance claims filed by beneficiaries of deceased employees. Deaths thatoccuramong employeesterminated without pension are not included since there is no uniform mechanism for Identificationofthese deaths.
Methods
To determine expected numbers of cases/deaths for the standarcized analysis, cancer incidenceand mortaltyratesfor Du Pont employees (and pensioners for mortality), specfoirf5-iyeacr age categories, sex and payroll cass (ie. wage or "sTahleanr,ytrhole),Coarmepacnoym-pwuitdeedifnorciedaecnhcec/amuosnealciaytergaotersy asrheomwuntiipnltiheedebnycltohseedcutmaubilaetsi.ve `midyear population of employees (and pensioners, whereapplicable)from each location, specfiorfaigec,sexand payroll class, over the entire study period. The sumoftheproducts overallage Groups stheexpected numberofcases ordeaths. Sntuamnbdearrsdiaznedd aarnealbyasseesdaroenparcetfuearlrepdlabnetcpaoupusleattihoenys.pronviidseolaagtee-dacdajsuesstewdheexrpeected `acourate population cata are not avaliable, proportionate Incidence or mortally analyses are presented.Inthese analyses, the observed distributionof ases/deaths by cause is comparedwith that expected derived from proportionswhich occur
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Testsof Statistical Significance
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ethnic origin, soclosconomic status or genetic factors.
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WASHINGTONWORKS
Cancer incidence
Nostatisticallysignificantexcesswas observedintheoverallcancerexperienceof employees at Washington Works from 1966-1989.
`There was, howsver, a statistically significant excess of cancers of the buccal cavity andpharynxamong malewage (8cases and2.8expected)andallmaleemployees. This elavation was reportedinthe 1956-1887 surveillance and no additional cases have occurred since that time.
Astatisticalysigrificantexcessofkidneyandother urinarycancerswasobserved `amongallmale employees (9 Cases versus 4.5 expected). Thisexcesswas also presentinthe 1956-1387 report, among male salaryaswell asallmaleemployees. One case has been diagnosed during 1988-1969.
A bladder cancer excess reported during 1956-1987 among male wage employees
is no longer statistically significant. No new cases have been reported during 1988
1989.
Theeariier findoifnagn eleviantmuitioplnemyelomaamongallmenisno longer
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statistically significant. No new cases have been reported during 1988-1989.
Anew finding s a statistically significant elevation in leukemia among male wage (7 `cases versus 3.01 expected) and all male employees(9casesversus 4.56expected). ``Twhaigseinecmrpelaoseyereessuistisncferotmhealnasatdrdetpioornta.lA3rceacseenst hcaasvei-ncgonbtereonl dsituadgynoofseldeuakmoenmgiaamtale `Washington Works foundnoassociation betwsen wrk in any area at the plant and development of leukemia.
No statistically significant deficits were observedinthe overall or she-specific cancer experiance of employees at Washington Works uring 1856-189.
Cancer experience among female employees was not unusual.
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Morahy Statisticallysignificant deficitsare again observed in the cverall mortality experience of male wage and all male employeesat WashingtonWorks,for 1857-1991.
Statistically significant deficits are seen for all malignant neoplasms among male `Wage (60 deathsversus78.4expected)andallmaleemployees(99deathsversus 124.8 expected). In addition,malewage employeesshow a statistically significant defictofrespiratorycancer deaths(19deathsversus28.6expected)andal male employees have a significant deficitof digestivecancer deaths (22 daaths varsus 320 expected).
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Asignificant deficits seen among all male employees for suicide (3 observed versus
10.8 expected).
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Among female employses, there is astatistically significant excessof residual causesofdeath (4 deaths versus 1.05expected).
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