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Nominal Concentration
20,000 ppm (ca. 200 mg/L)
Exposure Time
(hrs.)
4
10,000 ppm
4
(ca,, 100 mg/L)
23.4 rag/L
13,9 mg/L
Air Plow
(liters An in,)
1.96
1.98
2.00
2.28
Mortality Ratio
2/4
Clinical Signs of Toxic <ty_
Duri.np Sxpoavre: 40,000 ppm
same as at
After Exposure: 2/4 died 1 day
after exposure; Labored respi
ration and weight loss for
2 days
0/4
During Exposure: labored respi
ration; lacrlmation with pig-i
merited discharge around eyes
and nose
After Exposure: recovery withiin 1 day
"Bottom Fraction'
2/4
During Exposure; discomfort;^
labored respiration; gasping
After Exposure: labored respiration up to 9 days;
weight loss In one survivor
until sacrificed; death of 2/4
at 1 and 9 days
0/4
During Exposure: same as at
23.4 mg/L; irritation of nose,i
mouth and eyes, pigmented dis
charge from eyes, in addition; After Exposure: marked weight
loss first day followed by !
irregular losses and gains; "noisy" respiration for 8 days,
Gross P Nonleth;.! attributab
1<4 days po
Lethal Con
lung damag lung weigh 14 days po
of liver,
testes dep 14 days po Nor. lethal tion of lu pose expo
abscesses
-^
SKIM IRRITATION AND SENSITIZATION TESTS
Procedure: In the tost for primary irritancy, each material was applied undiluted, and as a sol-^i intact anrl abraded skin of 10 male palnea pigs. In the test Co produce skin sehsitization, each m undiluted Co the abraded skiii cf 10 male albino guinea pigs, nine times over a thiee-week period. weeks later, the animals were given challenge cests to intact and abraded skin to see whether they
Results:
Concentration
100% 107,*
24-Hour Observation of Irritation
HHHBBH----------------^^2906^
Mild to severe irritation on intact and abraded sRin Mild irritation on IntacC and abraded skin
100% 107,*
No Irritation on intact or abraded skin No irritation on intact or abraded sktn
100% 10%*
No irritation on intact or abraded skin No Irritation on ii.cact or abraded skin
1007. 107o*
Bo Irritation on intact or abraded skin No irritation on intact or abraded gktn
* 1:1 Acetone-dioxanc containing 13% guinea pig fat
** Higher-boiling liquid fraction only
Summary: Both fractions of the crude i-elomer mixcure have relatively low acute innalation toxic to c'.ie mucous membranes (such as eyes ind nose); at high concentrations, they produce a marked ir the lungs of rats. The "bott ;' fraction".consisting of liquid higher-boiling components, appeare
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p* is more toKic thanT----------~'------------------------
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The liquid fraction of the crude telomer mixture was irritating to the skin of guinea p produce an allergic contact dermatitis.
The other three mixtures were. non-irritating t" ^uinra pig skin; neither of them produc dermatitis,
HS/mfs Date: November 3, 1964
Report by:
/
^ ^ 7Henry
Chief, Oral T
Approved
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by: .^'^',-i'<?^/y . '
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J. V^ley
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