Document dQzb5qBZjReoVypEG4d0yk6YR

k 2-*: c. E . I . d u P o n t d eINCNOHl'eORmHror ou r s & C o m p a n y W il m in g t o n , D e l a w a r e 19898 P O L Y M L R P K O O U C ^ ir. DL ' r r, i r N I ELXPCFIN'rNIAL STATION PERSONAL AKD CONTIDENTIAL cc : A. J. Dahl B. V. Karrh L. J. Papa Pral File I.C. - 353 - NI 1400 - 269 -*&Ztb-l5O July 20, 1981 TO: DR. Y. L. POKER -- PPPDD,, Paarrkkeerrsi burg FROM: S. S. STAFFORD ANALYSIS OF BLOOD SAMPLES FOR FERFLUOROOCTANOATE (Job Ko. 810-578; PRAL Nos. 81-2952-2955; Notebook Nos. E22514,E26238) As requested in your letter of 7/14/81 to L. J. Papa, the 4 blood samples submitted then have been analyzed for perfluorooctanoate (Cg). Results and sample identification are given in the attached table. As noted there, the analyses were done using a gas chromatographic method specific for Cg (Lab Method Number ES-567) but results have been reported as ppm F for comparison with total organic fluorine analyses. Precision is + 10% relative standard deviation over most of the concentration range, somewhat less at the lowest values. The lower limit for quantitation is 0.007 ppm F (0.01 ppm perfluorooctanoic acid), with a detection limit of t 0.004 ppm which can be distinguished from the reagent background but not well quantitated. Please contact me (772-4440) or L. J. Papa (772-2745) if you have any questions regarding the analyses. General questions on blood sampling can be directed to J. K. Raines or L. F. Percival. Attachment j ah Key Kords: Perflurooctanoic Acid Perfluorooctanoate Blood Analysis GC Thc-ff s g w o 'ld o! thin gs re- doing som ething about 000108 EXPO00042 EID713856 co:;_ch;.'iR- TABLE I Sample FRAL No. Date Sampled 81-2952 6/9/81 81-2953 6/12/61 81-2954 6/18/81 81-2955 6/18/81 P.R.No. 4543 VS VS 1581 Name (a)_ GC Analyses____ Date Analyze d I_e o _ 7/14/81 0.61 7/14/81 0.51 7/14/81 1.2 7/14/81 0.15 (a) Analysis as described in Lab Method ES-567 ("Determination of Per fluorooctar.oi Acid in Blood, Gas Chromatographic Method", S. Stafford, 4/3/81), using the packed column GC analysis with perfluoro-n-octanoic acid as calibration stands (b) Although the analysis is specifically for perfluorooctanoate (acid or salts), concentrations are given in ppm fluorine for comparison with the results of total organic fluorine analyses. (ppm F = 0.6S3 x ppm periluorooctar.oic acid) Estimated uncertainty is + 10% relative standard deviation. The lover limit for quantitation is 0.007 pgF/g. The detection limit is 'v 0.004 pgF/g, but concentrations in that range cannot be well quantitated and are reported as < 0.007. None detected (n.d.) is reported for samples with [Cg] < 0.004 ppm. which cannot be distinguished from reagent background. REDACTED* EXP000043 EID713857 000109