Document dQZO6x3p7YmKRoeo07v0jxNk0

,: -O V/M'r 7 h r : ,MATERIAL. RE DR, KEHCH'o COETEMPLATBP PUBLICATION I I' HJTciiE iCCXTERlI:.'G*:HLD1AN* SUBJECTS 'LEAD 'STUDIES I - "" ~~~ ~ ' - `' " ;. . . The Harbsn Lectures, 1960 (Kehoe) The Absorption, Excretion, and Retention of Ingested Lead by Human Experimental Subjects' (P. J. Whitaker, Thesis, 1951} The Fate of Inhaled Particulate Lead Compounds (Kehos -- Sent to Washington, . Feb, 2, 1967) (Subjects JS, LB, till, SS, HR) . .` The Fate. of. Lead in- Human Food (Kehoe, Cholak, Hubbard, Bambach, liclJary, Story - Proceedings of the Sixin Pacific Science Congress, Vol. VI, Held at . Berkeley,.Stanford, and Sen Francisco. July 24-Aiig. 2, 1929, pp. 193-204) (: FA, HD) . . Lord Absorption and Ex-oretion. in Relation to the Diagnosis of Lead Poisoning (Rehoe, Thaihann,-' and Cholak - J. Ind. Iiyg. 15:320-40 (Sept.), 1933) (Subjects OB (Meqro age 45'-' Pb intoxication), JF,_RS, A/J, JG, .AS, E-Ic, E-J, H'A -- tissues, after death(all had exposure to..Pb); WK, PP, W3, .AG. .13, Si', HC, 3./ (child) , H (child), G (child) -- suffered Pb poisoning, etc. An Appraisal of the Lead... Hazards Associated with the Distribution and Use' of- Gasoline Containing Tetraethyl Lead (Kehoe, Thaiaann, C'holak - J. Ind.. Hyg. 36:100-23 (Mar.), .1934), (Filling Station attendants, Tank Wagon .Handlers, Garage Mechanics, Barrel Fillers -- 303. exposed men),' . ' ! . Efhyj. Corporation Inker-Office Correspond p>co: To: Dr. D .G ,. .- :, . -.-.-.-.a G rv Ter 'i:d.r.- . iub;- ;.cL:: .Vibit is Idslooting to Discuss Veto.. i.L-y ]2, LV/3, Detroit) . To discuss witn Dr. S. Gross his progress on eve :. .-.an . of data fro:a Kehce's numerous inhalation'and ingestion exposures to Pb .(17 individuals) ., .Also: To: Mr . Zaven. .From: B.A. Sobel,, ; Sa'payt: i/rocciosing of Kehoe -Experimental Data (May 22, 1975). v . .Memorandum' -cjn;an' Experimental Study of the Metabolism of Tetraethyl Lead in one Human Body (Kehoe, dov. IB, 1952). Lead (Tahoe) . (Distribution of Pb in the earth, its .waters, and its atmosphere; The absorption, excretion, distribution and accumulation of lead by. .nan; The composite patterns of the metabolism of lead in'man; The effects'of the: .'-absorption of excessive quantities of inorganic lead upon mart; The -therapy v .of lead poisoning) , .` . L.:".d ( ; t r - pharma. Therap. 1976, Vol. 10, pp. 000-000. Pergonon Press. ypr iii.ted,`i.a Great Britain Galley proof?). For contents, sea entry', above. .' . :'i>;-ech by Kehoe (af ter retirement is head, of- Department of Environmental health, College of Medicine, University of Cincinnati) -- Statement dealing v.'ith three, j.schas of primary importance on the consideration of the national, international, end local problem of lead ir. 'the air, insofar as such airborne lead is derived . from the emission of lead: compounds fresa autovnobil.es -propelled by fuyi con taining lead -antiknock compounds: 1. The inhibition of deltnaminolavulinic acid '. doriydrase by lead -(ALAD).,. (2) De tervaination of .tolerable concentration.of lead in air in combination with load in food and beverages, (3) 7 gse 'the- conclusion. `Statement Concerning the Hygienic Aspect-- of Lead in the Hainan.Environment by Kehoe, Professor Emeritus of Occupational Medicine, Department qf Environ mental Health, College of Medicine, University of Cincinnati. Purpose: To present and to document the salient facts concerning the hygienic aspects of the occurrence and distribution of Lead in the environment of citizens of the United States of America, with- particular reference to the contri- button made by the use of leaded gasoline. (Includes The Three-City Study, January, 1965; human subject experiments called."balance experiments (1937 ingestion, 1359 --inhalation). Also includes al.l the publications in which, so far, Dr. Kehoe. has given results from the "human experiments.) The Role of Occupational Medicine in Modern Society by Kehoe (this was given to Dr. Bennis). . . - - : ' ' ". ' ' References of Human Subjects to Lead Compounds (Kehoe - Ind. Med. and Surgery . 28:3, 156-9 (Mar.), 1959). This is a progress report on an experimental investigation of factors which influence the responses of human subjects to finely divided lead compounds in the atmosphere. Includes pictures of the respiratory chamber ana a discussion on it, nature of the lead compound used, and results of six experiments. . , Statement on the Potential Hazard to the Public Health Associated with Lead . . in the Atmosphere of American Cities (Kehoe, October 10, 1961, Kettering Laboratory in the Department of Preventive Medicine and Industrial Health, , College of Medicine, University of Cincinnati, Ohio). This is a presenta tion of salient facts concerning hygienic aspects of distribution and use of gasoline containing alkyl compounds of lead, introduced in foxtaulations ' of antiknock compounds. ~ `. M . "oKnv-hia:. Costribebion of Industry to the Health of the Ration {Kehoe -- .' e.K OPr'Pd- d:.-. 10:3-3 (Jan.)., '1363.--- First Rutherford T. Johnstone .L e p t u . r e ) 'B e . Kehoe's introduction was revised b y the;editor.of -the journal without consulting Dr.; Kehoe, thereby omitting, a-necessary'point Iiv Or. ' Kehoe' s purpose. ' -- ' Typewritten.-copy;of the '-above with the original introduction.. _' .Experimental. Studies -on Lead .Absorption and Excretion and Their Relation, to .; the Diagnosis -and Treatment of Lead, Poisoning (Kehoe, Cholak', Hubbard, Uambach, and McHary -- .j.. Ind. Hyg. Toxicol. 25:71-9 (Feb. ), i s m * Brief (?) resume of-the Kettering human experiments-and resulting practical considerations. ., hxprrim-ratal Studies on the ingestion of Lead Compounds (Kehoe, Cholak, Hubbard, Laabach, licEary, and Story -- J . .Ind. Hyg. Toxicol. 22:38.1-400 (Hov.) , 1940) . ' IJascrjjptlon of stadias on safe limits of lead ingestion in food and beverages . ,'in regard . to the general population (3 'subjsets, >SP.and EB (experimental; Cu . , and.HD (controls). Conclusion: There is a sufficient factor of safety in J relation tq '.the lead content of the general food materials in the United States ^ 0004406 Expariiaental-'Studies on Lead Absorption and Excretion and Their dilation to the Diagnosis and Treatment of Lend Poisoning (iiehos, Cholak, Hubbard, Bambach, and 'ic'dary -- paper presented: at the April, 1942 meeting of the American Industrial Hygiene. Association. 'J. Ind. ilyg. Toxicol. 25, 71:9 (Feb.),1943). Review of the oral lead experiments with human subjects. Conclusion, so far: Within the limits of lead absorption dealt with in these experiments, the. lead metabolism 'is exceedingly stable, so stable, in fact, that it is not important}y influenced by gross changes in the . acid-base equilibrium or by the calcium and phosphorous metabolism of the body. : ' . Experimental Studies on the- Inhalation of Lead by Human Subjects (Kehoe -- Pure hud Applied Chemistry 3:129-44, .1951). Experiments on biological significance .of load which b e gan'in 1927-28; few years later, oral ingestion experiments; 1950, inhalation experiments with human subjects, which are described herein. Tra lead, respiratory chambers are described, a brief description of clinical observations is made on a human subject, the health care taken of an accepted'' 'eject during experimental exposure is given, h-ruy diffraction pattern of . , J chd compound employed in the. expsrimants is shown, and the experimental . results are detailed (1-103, EC) . The most significant result of these expari- . .m e r its is the fact that, no hazard of lead poisoning is associated witn the ir>.natation of air containing a fully respirable and absorbable compound of lead in the concentration of 0 .1 5 . iag/ m ^ , over the period of; nearly two years, . huger j.tnents were carried out under conditions that simulated those of industry expect for their strict, uniformity and their virtually complete elimination. . o f the ingestion of lead i n connection with the da y 's wotk. Prom long exoari- ; once in medical supervision and clinical monitoring of industrial employcos, Is. was found, that man whose regular rata of urinary lead excretion, over a ; '.-.' 'led of many yearn of Kta.b5J.ixed erne cure, in rep-rea,-n-nted bs? a. c-ow:capr:ahio`' p u p o to T.ead- (ICahce -- Occupational 1-Ipdicina 3:156.-71, 1947).'. S u m e r i - of 'j.nroe ra tion /on exposure 'to lead and problems industrial physicians- and : 'industrial hygienists: have to face, as covered in three headings: (1) nig- .,pif-loanee of exposure Of public to land, (2) certain aspects' of industriiti cr.yonur to .lead, (3) problems of diagnosis. Subjects S3,. IP, I-IR, SV7- ' a arre discussed in .relation to lead hi food -and drink, etc.. . f - Prog rep:;.. Report on Project Ho. LC--75, `'human Exposure to Ambient Air Concern ' 'trafciovns of Particulate Lead." 1962-63. .Inhalation experimets - subjects - ; 11 .and S3 - . .... .hsnrf if Progress (as of July 31, 1966). In a n .Investigation of "Human. Exposure ;toypartioulata 'Lead''Compounds.in. the Air under Experir.ental Condirai one ' ',,"7-Aprpjoct Nq .' Lki-75 - of International Lead Zinc -Restorea Organisation. ' pro joe h of ^American Poitroleum Inctituba (as of aprii. 25, '1956) . Project . - .f -P b-9220--01-05 - Public Health;'Service Research. Grant (entitled) `'Tire ; of Inhaled Particulate Lead Compounds." (ICehoe) Includes', it list of references of publications- which give the principal findings of the investi. g a b i o n s v.-j.th human subjects. ---iso includes details of oxppri.rabn'ts'carried , oe'c cinca 1952 (design, of experiment, etc.) 0004407 uprndum of. Prograss Report LII-75. Particulate Load Compounds in the air Under- Experimental Condition::;. (hahoe) day 6, 1966. Subject Kt and ss Report of Progress in an Investigation of "Tae Fate of Inhaled Particulate Lead Compounds." (Kehoa) February 2 , 1967.' (Marked!"luconolete.'} Includes graphs -- Subjects Lb and JS. -* ^Vnasa stars give good .information conte.::pl.ted; publication. n can be used in the writing.-of Or, h;i c e 's FsteiU: yurge rd May 6, 1900 . K % 0:004408