Document dQXokq6XMpy34XQrbN807L21G
AR226-2828
E. I. du Font de Nemours and Company
Haskell Laboratoi-y for Toxicology and Industrial Medicine
HASKELL LABORATORY REPORT NO. 93-71
MR N0.1
Material Tested; Material Submitted by:
Organic Chemicals Department, Jacksci Laboratory
Haskell No.: Other Codes;
6869
ACUTE ORAL TEST
Procedure: The test niaterial, as an aqueous suspension, was administ ered by intragastric intubation ChR-CD male rats in single doses. Survivors were sacrificed 14 days later.
Results:
Suspension (%)
40 40 40 40 40 12 12
Dose
(me/ke)
17,0004:
11,000* 7,500 5,000 3,400 2,250
670
Mortality!
D - 2 d. S - 14 d. S - 14 d. S - 14 d. S - 14 d. S - 14 d. S - 14 d.
Clinical Signs
Lethal Dose: Prostration on day of dosing; incoordination, weak hypothermia, pallor, prostration, and weight loss on day after
dosing
Nonlethal Doses: Pallor and hypothermia on day of dosing and weakness on day after dosing at 7500 ing/kg and above; incoordina on day of dosing at 5000 mg/kg and above; weight loss for L-3 da
+ D - ( ) d. = Found dead ( ) days after dosing; S * Given in divided doses
( ) d.
Sacrificed ( ) days after doeing
Company s^^-o'-"0'"""'"^0
-
2 -
to younige a~o3Silt ChRR--C( D male rats in single dosesB; its Approximate Lethal Dose (ALD) is 17,000 mg/kg of
Report by:.
^^f&UJ^LJ
Laurel S. Wa Oral Toxicology
NB 942, p. 78 LSW:pgh
Date: April 6.
1971
Approved by:
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D4irreeccttor
-^>iol Company Sanit.Ksa.... Oe'2- !ot contain TSCA