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@ AR226-3349 Development of analytical methodology for determination of Telomer B Alcohols, Telomer-derived anionic, nonionic fluorosurfactants and polymers. Bogdan Szostek, Keith B. Prickett, Janet C. Maslanka, and EE EEE 1puPont Haskell Laboratory for Health'and Environmental Sciences, Newark, DE, USA Telomer B Alcohols and Telomer-derived Surfactants and Polymers Telomer alcohols: CF5-(CF,),-CH-CH,-OH n=3,5,7,9,10, 8-2 Telomer B Alcohol: CF,-(CF,),-CHy*CH,-OH A] Polymers: (Ces(CF I Cit Ci OLPOOL?) BTS | TEL CeWCTRI TRG Re cote m Ei f URW = CF3=(CF)CHsS-O;CCHNHy,* Non-ionic Surfactants: | CF3(CFy)aCHy CHyO-(CH,-CH,-0),H ee] environmental fate, and environmental effects studies for these materials, an | Analytical options for 8-2 Telomer B Alcohol Properties Structure: CF=(CF,),-CH,-CH,-OH Water solubility: 150 pg/L NEE =Boiling point: 213C at 760 mm Hg | - Vapor pressure: 3 Paat 21C LR 2. GC. + GEMS! -mostoften used ACE, | Sr CPUS eT 1. GC-FID - ERR =| oq Siwg/mi FETC EER, + | TET 40ug/mi Len odes == S L @ Basics of GE-MS method-- EI spectra DHE THT imam, 24, 24 perfuoradecan-i-ol =| sameusaremmaearns -r =] HHH - oar k Lo @ 8-2 TBA -- GC-MS method issues (SUE Eye BiV Ae - Methanol; IPA IE et " fo Le EN a TTT Time [hrs] ol TT Slump performance TT.= vl | Inj.#7 z 11 = rn ~ - Inj.#85 :z rE ET mm DE Environmental waters -- method validation and sample storage Experiment mw =fe i hf A. | en COa L CREE Results (% recovery t st. dev.) Te tt ST | a R n i e E |Fro| za eRnT |e RT(Nofoil|) Frozen Lud THI 102s | sess eau asad | 100k | 24st se LTH 9822 | otke S7#2 3082 1042 | 261s ETRY ois sexs | sass 2eas 10082 15 I oez2 mors | oasy 2esy sem: smi ah LER: ATe S 52 TBAcar n bo ionized by electroA spray RS arBaEdient bf walbri0msi)hanolis used; aqueous samplesin 60% acetonitrile HL RT am Stduirnesoo|| CC CRAr lT7 E7o o 0 S5% n a= 5t hl| ant | wea Resorts orl (R42) fe (Sur 548) |QtLin QighBccWight 1 AstarsNore: | ES| Ba;| 25-2550 ngimL 8-2 TBA LL ee SatsaraniS)| o so= m acme o === | | sBr e t an e an r anem w C wm S mam a oa) E @ Ethoxylate nonionic fluorosurfactant CF 3(CF)x-CHp-CH-0-(CH,-CH,-0),-H x=35,7911,13,... n= 0-25 Analytical methods: GC-FID eg) a Ethoxylate nonionic fluorosurfactant by GC-FID SE 8 =| | i =| =| 2] wo)iis o [I]t 2 i | | | | | 1a LUA AA . ol - 3.3 mg/mL ethoxylate fluorosurfactant imn ethanol Tis 5 7s Bo Tus 5 ws| m mn an | HASKELL Ethoxylate nonionic fluorosurfactant by LC-MS fCormiadtducits WR BN, in EE 5i+ ch HEN . 6-2 TBA ethoxylates 8-2 TBA ethoxylates 10-2 TBA ethoxylates 12-2 TBA ethoxylates J\ 14-2 TBA ethoxylates aTn Ebenie s @ EOCENE eT cyId Ae CF y-(CF)y-CH,-CH,-0-(CH,~CH,-0),H NH; " L 2d 10 ES o? ~ nett -- | + w $ " =e nets S5 J i" = ws 33 T i ~7 ow i-s eto 5s] r SlI bm ime |7 7nets Alltt a an | miesr ae ] <i & @ Ethoxylate nonionic fluorosurfactant by LC-MS samples a[ nd standar) ds need to contain 50% acetonitrile otherwise are unstable quantitation can be achieved by monitoring peak areas for individual TBA quantitatiE on can alse o be done n by monitoring selected group @fions for each TBA ethoxylates; CCoteset rieosebm 2Rr2a=e03t5213 CabistgeroaariosenetruineeS:ot58o5r0Ca9Sg1a64B00eg5sts2e+V23i80r74040s7 *rx4s116e47r7s on) 1 | | | || M om e ow r ow ome ih ozscout om || 1saBma|1 Rises] 25a] ons: | l 6905 | il 734.5 | 7786 Il 8226 i 866.6 | | | d I| e rr r ww r www Acrylate Telomer-based polymer BcRoepAoelyEmerof vr inylidene chloh rideP , TaloRmor HAcere and saary methacrylate 5000 -- = 4000 - a0 2% 200 1000 . 2000 A E 3 EFIn ag. :3 J/ \d Lei a0C0o0ncentration, m10r0t0.0 14000 Acrylate telomer-based polymer -- method validation and method application Buffertype | (9% recovery Fo 3 a Err) [oEes Te 101212 es 10005 Len [LEAN 10113 LC ILIA ET] 100210 -15000 mglLstd -SeDmay e5,npH40 ~~ [ ,| Rng 7 - |\ | i\ | J 7 \Non | | Ll 1 id =): A iin asca . Summary General remarks - discussed analytical methodology for analysis of 8-2 TBA, nonionic ethoxylate fluorosurfactant, and acrylate polymer; - cach analyte, even though derived from telomer chemistry, required individual and different approach; Is a single method for Ee _ analytical methods for many of the fluorinated compounds Gf interest are being established; rigorous method validation | | demonstrating proper spike recoveries in the matrix of interes | SE RR SS Ele SRC eee) | | O @ Summary Specific recommendations for analytes studied ERIN - can be analyzed either by GC/MS or LC/MS - volatility losses from water are rapid and significant; - aqueous samples should be stored frozen; - GC/MS methods are problematic for trace level analysis in complex matrices; - aqueous samples can be extracted with 60% MeCN for LEMS; ethoxylate fluorosurfactant: R - LC-MS analysis is advantageous: sensitivity and clear | identification of chemical species; | lo EeCE RA (Ee Ea - polymer can be isolated from aqueous matrix after wetting | with the help of fluorosurfactant; | - quantitative method was established based on LC-GPC analysi$: with RI detection; | |