Document dDDbd91Qz7J062ddKwRp2wee6

__ MINUTES OF MEETING CMA EXECUTIVE COMMITTEE Olympic Room,- Hyatt Regency on Capitol Hill Washington, D. C. Monday, November 2, 1981 1. The meeting was called to order at 1:30 p.m. by Chairman Simeral. There were present: William G. Simeral, Chairman Richard c. Ashley Harry W. Buchanan Louis Fernandez Alexander F. Giacco James B. Henderson Richard J. Hughes Richard H, Leet Paul F. Oreffice L. John Polite, Jr. Robert A. Roland George J. Sella, Jr. Konrad M. Weis Bruce M. Barackman, Secretary Edmund B. Frost, General Counsel Gary C. Herrman, Treasurer By Invitation: Jackson B. Browning, Union Carbide Corporation D. Chris Cathcart, CMA Geraldine V. Cox, CMA John E. Dull, E. I. du Pont de Nemours & Company William C. Krumrei, The Procter & Gamble Company Victor H. Peterson, CMA Ernest S. Robson, Jr., SOCMA, Monsanto Company James N. Sites, CMA William M. Stover, CMA Otto Sturzenegger, CIBA-GEIGY Corporation 2. Minutes of the Last Meeting meeting, as distributed, were approved. The minutes of the September 28, 1981 3. Treasurer's Report Mr. Herrman's report is attached as Exhibit A. In addition he advised that the financial statements through September 30, 1981 indicate significant variances only in the revenue area with dues being less than budget. This, however, is offset by greater investment revenue than anticipated. 4. Association Activities a. Report of Special Programs Advisory Committee Following the presentation of his report, Exhibit B, Dr. Sturzenegger recommended reauthorization of the Special Programs Advisory Committee for another year. This was approved. CMA 012746 Fluorocaxbons SFAC approved a limited advocacy role for the Fluorocarbons Program Panel so that the panel could make statements on science. The first was in response to the November 1979 NAS Report, "Stratospheric Ozone Depletion by Halocarbons: Chemistry and Transport." SPAC recommended that the panel continue its limited advocacy charter and appointed two members- to explore appropriate means of coordinating the Alliance, the CMA Fluorocarbons Panel and the CMA Section 4 Testing Task Force of the Chemical Regulations Advisory Committee. Ketones SPAC endorsed the panel's plans to establish an early dialogue with EPA regarding the anticipated TSCA Section 4(a) rule. However, SPAC recommended that the panel's charter be amended to include epidemiologic studies and possible evaluation of the environmental effects of ketone. Phthalate Esters In early 1980 the phthalate Esters panel planned a material handling survey of the manufacturers, distributors and users of phthalates. However, since CMA is a trade association representing manufacturers, SPAC recommended that all action be tabled until the Society of the Plastics Industry could be contacted. In the meantime a study by the National Cancer Institute became available which for the first time raised health effects concerns for phthalate esters. In addition, based upon NCI's findings, EPA requested additional information on PMNs for phthalate esters. The panel was concerned that EPA had taken regulatory action on preliminary information and that EPA might come up with an unreasonable TSCA section 4(a) rule. SPAC recommended that the panel add advocacy to its charter and that they establish a dialogue with EPA on developing a voluntary test standard. This was a valuable recommendation as can be seen by the subsequent accomplishments of this panel (section 7.4 of the attachment). Titanium Dioxide SPAC recommended that In the absence of any significant findings in the long-term inhalation study in progress at dupont, the panel consider disbanding. Vinyl Chloride The Vinyl Chloride Panel hired an independent consultant to review the work performed by Industrial Bio-Test (IBT) under coatract to CMA. This consultant recommended that CMA examine animal tissues still available from the study. The panel did not act upon this recommendation. However, they did ask IBT for a refund of che $130,000 they had already paid under the contract. The panel was waiting for financial resolution with IBT before submitting a final report to government agencies. SPAC recommended chat the panel not wait for resolution before submitting a final and report chat they act upon the consultants recommendation to do additional histopachology. The Panel followed this recommendation. 3 CMA 012747 8.10.Ethylene Dlchloride (EDC) - The Ethylene Dichloride Program Panel was formed in Febru ary, 1975 to evaluate the adequacy of knowledge relating to EDC, The panel initiated a chronic inhalation, a metabolic, and a teratogenic study in experimental animals. The Panel decided to disband, pending the acceptance of all final reports on this research. This decision was reversed when it was learned that EPA was considering proposing a TSCA Section 8(a) rule. 8.11 Ethylene Oxide (EO) A study conducted at Bus'ny-Run labs showed Ethylene Oxide to be carcinogenic in rats. Industry was interested in gathering information on the safe handling of Ethylene Oxide which led to the formation of the Ethylene Oxide Industry Council on July 30, 1981. The Council operates chrough an Executive Committee and four operating committees: Scientific, Regulatory, Finance and Membership, and Communications. The Council is developing information regarding responsible industry programs to: 1) control exposure to ethylene oxide; 2) to develop relevant scientific, technological and economic data; and, 3) to cooperate with other national and international organ izations having similar objectives. The Council will present, this Information and data to any United States federal, state or municipal governmental body considering regulatory controls on ethylene oxide so as to assure that such standards, regulations or policies, are reasonable, scientifically sound, and economi cally and socially effective. The Council developed a response to the petition filed by the Public Citizen Health Research Group and the American Fed eration of State, County and Municipal Employees to lower the exposure standard for ethylene oxide. The petition asked that the eight hour TWA be lowered from 50 ppm to 1 ppm and that a short-term exposure level of 5 ppm be established. Representa tives of the Council met with OSHA officials on September 2 to discuss industry's concern regarding the petition. On September 29 OSHA denied the petition. 8.12 Fluorocarbons (FC) The Fluorocarbon Program was formally organized in the Spring of 1973 with essentially all of the Free World producers of chlorofluorocarbons (CFCs) supporting the effort. The panel's initial purpose was to determine the fate of CFCs in the atmos phere and the effects they may produce on plants or animals. There was no suspicion of their effect on the stratosphere. With the publication of the Ozone Depletion Theory in June, 1974 the Program was expanded and accelerated. To date, over $10,000,000 has been spent on this research. There is no indica tion that the participants intend to curtail this effort in the Immediate future. 12 CMA 012748 eral agencies. The panel also reviewed a draft final report on a styrene pharmacokinetic 3tudy in mice. The latter study indi cated species differences with respect to acute styrene toxicity In rat3 and mice. The panel presently is assessing how these differences relate to man before proceeding further with a research program. The panel incorporated a Regulatory Task Group to address EPA's proposed regulations (NESHAP) for benzene emissions from ethyl benzene/styrene plants comments were submitted to EPA on June 1, 1981. 8.20 Titanium Dioxide (TD) In 1977, Du Pont initiated a review of the literature on titanium dioxide toxicity and concluded that further information was needed to answer possible questions which might be directed at titanium dioxide. The impact of the Toxic Substances Control Act also raised concern as to the adequacy of existing information. The panel has tentatively concluded that a historical mortality study is not justified at this time. The panel plans to terminate program activities if no new evidence of humanhealth effects is reported as a result of the two year inhalation^ studies being conducted by Du Pont. 8.21 Trichloroethylene (TCE) The Trichloroethylene Program Panel was formed on May 12, 1975 in response to an NCI Memorandum of Alert. The panel's primary concern was a long-term inhalation study. A contract was signed in 1975 with Industrial BIO-TEST Laboratories (IBT) to conduct such a study. The testing performed by IBT resulted in a number of grave inadequacies and a final report was not issued. Therefore, the CMA TCE Audit Task Group prepared an audit report. EPA's Cancer Assessment Group has asked the panel to provide validation of chamber concentrations for Che first 12 to 15 months of the IBT study. The panel is monitoring the progress of the NCI bioassay on TCE which involves several strains of mice and rats. Although the panel contemplated an epidemiological study, SOCMA determined chat a study population for an epidemiologic investigation would be too small to yield statistically signif icant results. Therefore, such a study was not conducted. 8.22 Vinyl Chloride (VC) Since 1972, the Program Panel has supported activities related to the accumulation and assessment of health and safety data of vinyl chloride monomer. .13 CMA 012749 After funding several animal studies, the emphasis on research shifted from toxicological investigations to the early diagnosis and clinical management of vinyl chloride-related injuries. The panel is also funding an update of a vinyl chloride epidemiology study of 10,000 workers. The panel has maintained a close liaison with SPI and several European-based companies. The present interest in polyvinyl chloride (PVC) dust control limits in the UK is being closely followed. Several months ago OSHA requested information on PVC dust; however, no notice has been published or other action taken. 8.23 Vinylidene Chloride (VDC) The Vinylidene Chloride Program Panel was formed in May 15, 1974 to investigate the potential toxicologic effects and pharma cokinetics of inhaled and ingested VDC in laboratory animals. Dow Chemical, which was planning research on VDC toxicology, agreed to convert its program into an industry-wide effort. The Two-Year Inhalation Toxicity and Oncogenicity Study of Vinylidene Chloride in Rats is stil in progress. The Work Practices Task Group of the panel prepared a Health and Safety Work Practices Guideline for Vinylidene Chloride to minimize exposure to vuu. rne guidelines were sent Tci the Director of NIOSH and the Project Manager for Criteria Documents at SRI. They received no other distribution. The panel is preparing to respond to a Health Risk Assess ment Criteria document on VDC under preparation by the EPA Cri teria and Health Assessment Group. OSHA does not have a standard for VDC and EPA is unlikely to require any further toxicity testing on VDC under TSCA Section 4. The pharmacokinetics and metabolism research show a species sensitivity of Mouse>Rat>Man. The total data bank Indicates oncogenicity is not observed without recurrent tissue damage and without a cytotoxic dose; a tumorigenic response In man would be an improbable event. 8.24 Zinc Dialkyl Dithlophosphates (ZDDP) The ZDDP Program Panel was chartered in November 1980 to conduct research on this class of oil additives. Aa a first step, gonadal toxicity studies of three ZDDP compounds were initiated In immature and mature rats and rabbits. Obvious species differences were observed between rabbits, and rata with respect to ZDDP toxicity. Consequently, the panel proposes to conduct a comparative in vivo pharmacokinetic study 19 CMA 012750 TABLE 1 BIOMEDICAL AND ENVIRONMENTAL SPECIAL PROGRAMS BUDGET SUMMARY PROGRAM Acrylonitrile Allyl Chloride Arsenic Benzene Butylated Hydroxytoluene Chlorobenzenes Epichlorohydrin Epoxy Resins Ethylene Dibromide Ethylene Dichloride Ethylene Oxide Glycol Ethers Ketones Phosgene Phthalate Esters Polychlorinated Biphenyls Rubber Additives Styrene Titanium Dioxide Trichloroethylene Vinyl Chloride Vinylidene Chloride Zinc Dialkyl Dithiophosphates Subtotal Fluorocarbons RESEARCH AND ADVOCACY COMMITMENT $ 728,484 309,500 10,000 3,048,684 21,944 370,722 315,032 -010,039 288,100 -0313,000 208,880 217,512 186,585 100,434 30,725 708,218 30,725 490,506 1,326,562 729,482 79,857 9,524,991 9,216,650 ADMINISTRATIVE EXPENSES $ 79,172 17,186 8,600 112,262 TOTAL $807,656 326,686 18,600 3,160,946 29,467 37,952 27,432 15,059 43,032 64,449 15,518 15,232 28,977 85,728 132,628 18,869 17,730 66,545 23,969 89,738 119,701 57,440 51,411 408,674 342,464 15,059 53,071 352,549 15,518 328,232 237,857 303,240 319,213 119,303 48,455 774,763 54,694 580,244 1,446,263 786,922 12,207 1,118,893 569,753 92,064 10,643,884 9,786,403 total $18,741,641 4 Fluorocarbons program from start thru May 30, 1981. to September 25, 1981. $1,688,646 $20,430,287 All other program* start to CMA 012751 CMA 0 1 2 7 5 2 `shared Figure I - Bloaedlcal and Fjnvlrooaental Special Proaroaa Division 1' NUMBER PROGRAM NAME 1. Acrylonitrile 2. Allyl Chloride 3. Arsenic 4. Benzene 5. Butyl ^ted^Hydroxytoluene 6. Chlorobenzenes 7. Eplchlorohydrln 8. Epoxy Resins 9. Ethylene D1bromide 10. Ethylene Bichloride 11. - Ethylene Oxide 12. Fluorocarbons 13. Glycol Ethers 14. Ketones 15. Phosgene 16. Phthalate Esters 17. Polychlorinated Biphenols 18. Rubber Additives 19. Styrene 20. Titanium Dioxide 21. Trichloroethylene 22. Vinyl Chloride 23. Vlnylldene Chloride 24. Zinc Dialkyl Dlthiopnosphates CMA 012753 LIST OF SPECIAL PROGRAMS PROGRAM TYPE START DATE Research 06/20/74 Research 08/19/75 Research and Advocacy 01/29/81 Research and Advocacy 02/08/77 Research and Advocacy Research Research Research and Advocacy Research . Research Research and Advocacy Research and Advocacy Research and Advocacy Research and Advocacy Research Research and Advocacy Advocacy Research and Advocacy Research and Advocacy Research Research Research and Advocacy Research 09/19/77 12/16/74 08/19/75 01/18/77 03/22/79 12/17/74 04/16/81 04/09/73 06/26/80 01/23/80 05/18/72 02/24/72 02/11/81 09/10/79 10/24/74 06/13/77 05/12/75 11/16/71 05/15/74 Research and Advocacy !10/02/80 COMPLETION DATE j, 08/31/80 Appendix B Appendix C COMPANIES PARTICIPATING IN SPECIAL PROGRAMS ABBOTT LABS Ethylene Oxide AIR PRODUCTS Vinyl Chloride AKZO CHEMIE BV Fluorocarbons ALLIED CORPORATION Fluorocarbons, Ketones, Phthalate Esters, Phosgene AMAX LEAD & ZINC, INC. Arsenic AMERICAN CYANAMID Acrylonitrile, Phthalate Esters, Rubber Additives AMERICAN HOECHST Styrene AMOCO Benzene, Styrene, Zinc Dialkyl Dithiophosphates ANACONDA COPPER COMPANY Arsenic ARGO CHEMICAL Benzene, Phthalate Esters, Polychlorinated Biphenyls ARCO/POLYMERS Styrene ASAHI-DOW LIMITED Vinylidene Chloride ASAHI GLASS CO., LTD. Fluorocarbons, Vinylidene Chloride ASARCO INC. Arsenic ASHLAND CHEMICAL Benzene ASSOCIATED OCTEL COMPANY Ethylene Dibromide CMA 012754 C-2 AUSTRALIAN- FLUORINE CHEMICALS PARTY, LTD. Fluorocarbons BASF WYANApPTTE Ethylene DicfUori.de, Ethylene-Oxide, Phosgene, Phthalate Esters. 3ECT0N DICKINSON Ethylene oxide BETHLEHEM STEEL Benzene BORDEN CHEMICAL Ethylene Dichloride, Phthalate Esters, Vinyl Chloride BORG-WARNER CHEMICALS Acrylonitrile, Styrene BRISTOL LABS Ethylene Oxide C-I-L, INC. Trichloroethylene CELANESE PLASTICS SPECIALTIES CO. Epoxy Resins, Ethylene Oxide CERTAIN-TEED Vinyl Chloride CHESEBROUGH PONDS Ethylene Oxide CHEVRON Phthalate Esters, Zinc Dialkyl Dithiophosphates CIBA-GEIGY Epoxy Resins CONOCO CHEMICALS Ethylene Dichloride, Ethylene Oxide, Phthalate Esters, Vinyl Chloride COSDEN OIL Benzene, Styrene CRESCENT MANUFACTURING CO Ethylene Oxide DAIKIN KOGYO CO. LTD. Fluorocarbons i CMA 012755 DART INDUSTRIES ButylatedTMdydroxytoluene DIAMOND SHAMROCK Arsenic, Ethylene Dichloride, Polychlorinated Biphenyls, Phthalate Esters, Trichloroethylene, Vinyl Chloride DOW CHEMICAL Acrylonitrile, Allyl Chloride, Benzene, Chlorobenzenes, Epoxy Resins, Ethylene Dibromide, Ethylene Dichloride, Ethylene Oxide, Glycol Ethers, Ketones, Styrene, Trichloroethylene, Vinyl Chloride, Vinylidene Chloride E. I, DU PONT DE NEMOURS & CO. Acrylonitrile, Benzene, Ethylene Dichloride, Fluorocarbons, Phosgene, Phthalate Esters, Polychlorinated Biphenyls, Titanium Dioxide, vinylidene Chloride DU PONT CANADA INC. Fluorocarbons ELCO CORPORATION Zinc Dialkyl Dithiophosphates EL PASO PRODUCTS COMPANY Styrene EASTMAN KODAK Polychlorinated Biphenyls ESSEX CHEMICAL (RACON) Fluorocarbons ETHYL CORPORATION Allyl Chloride, Ethylene Dibromide, Ethylene Dichloride, Phthalate Esters, Trichloroethylene, vinyl Chloride, Zinc Dialkyl Dithiophosphates EXXON Benzene, Ketones, Polychlorinated Biphenyls, Phthalate Esters, vinyl Chloride, Zinc Dialkyl Dithiophosphates FOXMATIC CORP Ethylene Oxide GENERAL ELECTRIC Phosgene, Phthalate Esters, Polychlorinated Biphenyls GENERAL TIRE & RUBBER Phthalate Esters, Vinyl Chloride CMA 012756 C-4 BFGOODRICH Allyl Chloride, Ethylene Dichloride, Rubber Additives, Vinyl Chloride, Vinylidene Chloride GOODYEAR TLRE & RUBBER Rubber Adtfitives, vinyl Chloride W. Ri GRACE Vinyl cnxoride, Vinylidene Chloride GREAT AMERICAN CHEMICAL Vinyl Chloride GREAT LAKES Ethylene Dibromide GULF CHEMICAL CO. Acrylonitrile, Benzene, Ethylene. Dichloride, Styrene, Vinyl Chloride GULF & WESTERN Titanium Dioxide HALCON Ethylene Oxide HOECHST AG/AMERICAN HOECHST Fluorocarbons HOOKER CHEMICAL Polychlorinated Biphenyls, Trichloroethylene, Vinyl Chloride ICI AMERICAS Ethylene Dichloride, Glycol Ethers, Vinyl Chloride IMPERIAL CHEMICAL INDUSTRIES PLC Fluorocarbons, Trichloroethylene INMONT CORPORATION Phthalate Esters ISC CHEMICALS LTD Fluorocarbons JAPAN FLON GAS ASSOC. Fluorocarbons JOHNSON & JOHNSON Ethylene Oxide CMA 012757 05 KAISER ALUMINUM AND CHEMICAL CORP Fluoccarbons, Polychlorinated Biphenyls KALI CHEMIE*~AG Fluorocarbons KENDALL CO Ethylene Oxide KEY50R-CENTURY Vinyl Chloride KOPPERS COMPANY Arsenic, Benzene, Butylated Hydroxytoluene, Phthalate Esters KUREHA CHEMICAL INDUSTRY Vinylidene Chloride LUBRIZOL Zinc Dialkyl Dithiophosphates MALLINCKRODT INC Ethylene Oxide MICRO BIOTROL Ethylene Oxide MITSUI FLUOROCHEMICALS LTD F1uo roc ar bon s ' MOBAY CHEMICAL Phosgene, Rubber Additives MOBIL OIL CORPORATION Benzene, Phthalate Esters MONSANTO COMPANY Acrylonitrile, Benzene, Chlorobenzenes, Ketones, Polychlorinated Biphenyls, Phthalate Esters, Rubber Additives, Styrene, Vinyl Chloride, Vinylidene Chloride MONTEDISON SPA . Fluorocarbons, Phosgene MONTROSE CHEMICAL CORP OF CA Chlorobenzenes MORTON CHEMICAL vinylidene Chloride CMA 012758 NALCO CHEMICAL COMPANY Ethylene Oxide ML INDUSTRIES Titanium-Dioxide OLIN CORPORATION Glycol Et^ersT Polychlorinated Biphenyls, Phosgene, Vinylidene Chloride OSMOSE WOOD PRESERVING COMPANY Arsenic PANTASOTE Phthalate Esters PENNWALT Arsenic, Fluorocarbons, Rubber Additives PHILLIPS PETROLEUM COMPANY Benzene PPG INDUSTRIES Chlorobenzenes, Ethylene Dibromide, Ethylene Dichloride, Ethylene Oxide, Glycol Ethers, Polychlorinated Biphenyls, Phosgene, Trichloroethylene, Vinyl Chloride, Vinylidene Chloride POLYSAR LIMITED Benzene PRODUITS CHIMIQUES UGINE KUHLMANN Fluorocar bo ns REICHHOLD CHEMICALS Epoxy Resins ROHM & HAAS Vinylidene Dichloride RUBICON Phosgene SALSBURY LABS Arsenic SCM CORPORATION Titanium Dioxide SHELL CHEMICAL COMPANY Allyl Chloride, Benzene, Butylated Hydroxytoluene, Epoxy Resins, Ethylene Dichloride, Ethylene Oxide, Glycol Ethers, Ketones, Phthalate Esters, Vinyl Chloride, Styrene, Zinc DialJcyl Dithiophosphates, SHERWIN WILLIAMS Butylated Hydroxytoluene CMA 012759 SHERWOOD MEDICAL Ethylene -Oxide SHOWA DENK(TKK Fluorocarbons STANDARD CHLORINE CHEMICAL CO Chlorobenzenes STANDARD OIL (OHIO) Acrylonitrile, Benzene STANGE COMPANY Ethylene Oxide STAUFFER CHEMICAL Ethylene Dichloride, Phosgene, Phthalate Esters, Polychlorinated Biphenyls, Vinyl Chloride STEPEN CHEMICAL Phthalate Esters SUN PETROLEUM PRODUCTS Styrene SUNSHINE MINING CO Arsenic TECKNOR-APEX Phthalate Esters TENNESSEE EASTMAN Acrylonitrile, Glycol Ethers, Ketones, Phthalate Esters, Vinylidene Chloride TENNECO CHEMICALS Vinyl Chloride TEXACO INC Benzene, Ethylene Oxide, Glycol Ethers, Zinc Dialkyl Dithiophosphates, TIOXIDE CANADA, LTD Titanium Dioxide TOMS RIVER Phosgene TRAVENOL LABS Ethylene Oxide UNION CARBIDE Benzene, Ethylene Dichloride, Ethylene Oxide, Glycol Ethers, Ketones, Polychlorinated Biphenyls, Phosgene, Phthalate Esters, Styrene, Vinyl Chloride 1 CMA 012760 C-8 UNION OIL OF CA Vinylidene Chloride UNIROYAL, rNC. Acrylonitrile, Butylated Hydroxytoluene, Rubber Additives, Vinyl Chloride USS CHEMICALS Benzene, Fnthalate Esters, Styrene UPJOHN COMPANY Phosgene VULCAN MATERIALS Ethylene Dichloride, Polychlorinated Biphenyls WITCO CHEMICALS Phthalate esters WARREN CHEMICAL CO Ethylene Oxide 9/25/81 CMA 012761