Document dD2Xgr9wVDwdEaxk28NbKoRR0

I - % < S EXITROXMEXTAL HEALTH Inailer Than Screen Siiei into Graded tnduiir. Hyg. & Toxicol. 11:245-256 E. B.: Cotorimeiric Determination Metals, Ed. 2, New York, Inter* hen, Inc., 1950 nn, H. }, and Grogan. C. H.: Uni, National Cancer Institute. I Encyclopedia of Organic Chemby E. Joseph}- and F. Radt, New am, Elseiver Press. Inc., Y'ol. 14, t. p- 457. nn, I, and Schoental. R.: The 3,4-Benipyrene in Mice and Rati, Hydroxy and Ouinone Derivativei tion ot Their Biological Significance, 1:145-158 (March) 1943. Falk, H. L.; Lijiruky, W, and - Inhibition ot* Scene Carcinogen! wtially Hydrogenated Derivative*. * (Jan. 20) 1956. . T.: Stangtr. D. W.; Pino, A.; bubik, P, and Wartman, VV. B.t 9,10-Dimethyl-1,2-Beruanthracene *U in Mice by Polycyclic Hydror Re*. 11:892-897 (Nov.) 1951. C jl Asbestosis and Carcinoma of the Lung Case Report and Review of the Literature IONM ANOMMM. IU, Mtf IUNCII A. CM4PA044A. M-ft. to* fmdaao I'ueumonoconiosis and, in particular, asIvsinsis have been the subject of many complete re]rts as to etiology, prevalence, vie.1 However, the coexistence and possible relationship of asbestosit and carcinoma of the lung has beett rejtorted rather infrel|uetltly.,,I In particular, there are only 23 eases of asbestosis and lunf carcinoma with emuplete autopsy re|x>rts that have been documented in the literature: Isselbacher 11 r<-|*irtcd 21 caes, Todd: rc|<orted 1 case, ami Lynch1 re]iorted 1 case. I.vnch re1'iried two cases but only one with autopsy hndings. Doll* rc|*orttd necrupsies on 105 -i-liestus workers, in which 16 had lunc carcinomas, 15 of which were associated with asbe>tosis: coni|ilete autopsy data was mil given. Hare reports, as the one bv Cartier,12 attempt to disprove any relationship be tween the two conditions, but not enough mninnation is presented in this report for ve..|ti;itiiin. Report of Cate -'year-old white man of Italian extraniun dinitied to St. Mary'* Hotpital on May 8. Ilii rliicf complaint* were ihortnet* of ' on exertion and loss n( appetite of tour >e month*' duration. He rlenied nortum.il ea or ankle edema. He admitted, however, to 'time cough for approximately lix month* ti was productive oi yellow mucu*. Tltere alio two bout* of hemoptyiit of minor degree and six month* prior to entry. On each ' 'don they lasted two day* and were intermit- *1 t,T. h'tveived for publication Sept. 17, 1959. '"dttarn Resident in Medicine. Second Medical *'*'**. St. Mary's Iloapital (Dr. Anderson); '^tending Physician, St Mary'* Hospital (Dr. ^'upagaa). There was a JO lb. weight loss over a lix-montli period ami considerable fatigue. He also noted dubbing of his fingers for ''some years." For JO year* the patient lad worked actively as an asbestos insulator, working both inside and out and in new and old buildings. This emailed cutting, molding, and applying asbestos insulation to pipes, boilers, etc. At no time lad he or his associates worn any protective mask. He had worked full-time until one week prior to hos pitalisation. He also had considerable contact with I'ihcrgla*. He had not smoked in the past five tors. I>ut prior to tlat he had smoked three lackagcs of cigarettes daily lor many years. There wa- a moileralely heavy alcohol intake, primarily wine, in the past six months. Family history was negative tor malignancy There was contact 20 years previous with a brother who had lubcrculosil I'lis steal examination revealed an cxtrcmelv vniactaicd and dyspncic white man. appearing chronically ill. The blood pressure was 140,100 in Mb arms, pulse 84 and regular, temperature IU04 rcctally, respiration 24. height - ft 10 in., weight I22b$ lb. There was marked clubbing of the fingers and trws Ixrt no cyanosis. There was lshicr.il arcus senilis. No abnormalities were notesi in ilie neck. The chest showed reduccsl excursion in loth lure fields. Dullness and loth ilecrcased hrrnili >oumU anl ircmitiis were notesi on die right imvlviug tlw entire lower half of the lung field Meiliitm dry rales which did not clear seerc heard anieriorty amt posteriorly in the inferior areas nf loth lungs. The lirart was not enlarged to percussion or palpation, ami no murmurs were present. There was a split first sound at the apex Complete examination otherwise was within normal limits. Laboratory stuslies on entry showed a Itg of IJ gm.; RliC 4.58X10'; WBC 8.850. with poly- mocphonuclears 78, nonsegmenters 7, lymphocytes 10. monocytes 2. and eosinophils 1: FBS 112 mg.; RL'N 16 mg.; serum albumin J.5 cm ; globulin J.l gm.; thymol turbidity, arid phospltatase. direct and indirect bilirubin, amylase, ansi rlrrtrnlyte panel -were normal. The allaline phoaplaiase was 6.5 and 5.9 Boilamky units on two occasions. Urine* shewed pertinent ld--24- albuminuria. I. E.-cell preparation, Kalin and Kolmer, and bloat \ J9/27 SCF-FA-4865 8004 0030 HFM -011691