Document d9Z5bnmYoj7jxv8w9D9ej9X9

A R 226-2880 # C op ies to :1 E X du Pont de Nemours and Company _ Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, Newark, Delaware 19711 Material Tested* m HASKELL LABRATORY REPORT NO. j_24~7.9_ Ha ske11 NO. 12,943 Study Initiated/ other Codes Completed Material Submitted by_____ 3/27-3/30/79 ^ ^ P H H j U C D & P Department, WL Jakson Laboratory. EYE IRRITATION TEST IN RABBITS Procedure: One-tenth milliliter of a 2% and a O. W ^^seconds!' 1 treated eye was int_o the right conjunctiva sac of e a c h f rL t e d waisshheed with tap water for 1 minute. Tnhe treated e v e o f t h e other rabbi_t_ was ey h^!-'md^-slLt *lmp"at t1 and n44othouwrasus,nheuda.nd uOubosceor-vvabtvi*own..s at 1, 2, and ofa a r B / n " ar U 4 a% t r-i r " r a*1 \ S c ^ f c o ; e " erehuaed at s a n a t i o n s afte,- the day of treatment. 3 Results : solution 2% Dose 0 .1 ml liq u id Treatment Not Washed Cornea None 2% 0 .2% 0 .2% 0 . 1 il liq u id Washed 0.1 ml liquid Not Washe|d 0 ,1 mi liquid Washed None None None Iris Ocular Effects Conjunctiva Very slight Moderate 1-4 hrs. injection of None vessels 1-4 hrs. Discharge: Mild at 1 hr.; moderate at 4 hrs. None RednesB: Mild 1-4 hrs. Swellinig: None Discharget Mild 1-4 hrs. None Redness 1 None swelling: None Discharge: None None Redness: None . swelling: None Discharge: None Company Sanitized. Does not contain T SCA CB1 -2 i' I - 12 q4 3 \ wh8U tested as a 2% solution in water caused a very alight injection i r ^ ^ n ^ ^ ^ hHs i a(hn-t1'm2,o94d3e)ravTMt e8nc o n ju n c t iv a l iirrrriitattaitoino^nwwlittnh^ nnoo corneal effects in the unwashed TSn.ient moderate conjun^ ti J t.nt miia conjunctival irritation with no J*gSk\not an S l contact should occur a S S r ^ JS S r S S - it Report by: lI LA (2shf~Uj -- > . - '1 t i- f ( "77 Raj/anhe L. Feren^- U Toxicologist^ Approved by Gerald-la. Kennedy Chief, Acute investigations Section RLF/aph | R ep ort No. 324-"/9 B ")ate Is s u e d i A u gu st 24, 1979 Company Sanitized. Does not contain TSCA CBl