Document bymD95oJQdKXXwmx0Z538ELY1

'IJjL August 26, 1958 Nr. Herbert A. Cohen Research and Development Block Drug Company, Inc. 257 Corheliaon Avenue Jersey City 2, New Jersey Ret "Bake11te" Resins EDBC and EDBM Vinyl Bthyl Ether Resina Dear Nr. Cohen: In reply to your letter of August 12, 1958, we would summarize as follows our toxicity data on vinyl ethyl ether, CH2CH0C2H5. Single oral dose to standard rata 0 (amount which kills one-half of the nlmals tested) 8.16 grams per kilogram body weight. Single skin absorption by rabbits, one-day dam test 20 milliliters per kilogram killed one of four. Thirty day Inhalation by rats A,000 parts per million for eight hours per day had no effect. Primary irritation, rabbit belly vesicant test Undiluted gave no Irritation. Eye injury from fluid to rabbits An excess gave a trace of Injury. Unr 63?33 Nr. 8. A. C hen a- August 26, 1958 Regardlng the toxicity of polyvinyl othyl other room vo have noted the following! Bepeated dose to rata in the diet 28 days at 100 in the diet (10.4 grams per kilogram per day) bad no effect. Primary irritation, rabbit belly vesicant test 20jl solution in ethyl ether gave only traoe of capillary injection. Sye injury to rabbits log solution In deodorized kerosene caused no injury. We hope the above information will be helpful. Zf we may be of further service, do not hesitate to let us know. Very truly yours. Thomas V. Rale, N. D. rsb MEDICAL DIRECTOR ucc 063234 BLOCK DRUG COMPANY nc 57 CORNELISON AVE..JESY CJTY rN,J. August 12, 1958 Dr. Nale Union Carbide Chemicals Company 30 East U2nd Street New York 17, New York Dear Dr. Nale: With reference to our recent telephone conversation concerning the toxicity of the Bakelite Resins EDBC and EDBM (vinyl ethyl ether resins), we would appreciate any data or information on toxicity studies you have performed on these materials. This will enable us to proceed further with our own work on these resins. We understand that your evaluation of these products was not a complete study, but nevertheless it will give us some basis for determining the advisability of doing additional studies. We sincerely appreciate your cooperation and look forward to hearing from you at your earliest convenience. Very truly yours. HAC/amj Herbert A. Cohen Research and Development ucc 063235 AUG 1 3 1953 UPfr'viii. 'Aii.C!#*