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DOW CHEMICAL LAD SOLVENTS / EDC 1 OSHA HAZARD COMMUNICATION MANUAL CFR29 1910.1200 INTERPRETING MATERIAL SAFETY DATA SHEETS The Material Safety Data Sheet (MSDS) is essentially a technical bulletin which contains information about a chemical. The MSDS is prepared by the manufacturer of the chemical and provided to the downstream purchasers and/or users of the chemical. The information in the MSDS is normally divided into sections, such as follows; SECTION I INGREDIENTS Lists the percent of the chemicals that are contained in the product, any trade name, and the Chemical Abstract Service number. SECTION II PHYSICAL DATA Describes the chemical's appearance, odor, and other characteristics. Boiling point, for example, is the temperature at which the chemical begins to boil and turn into a vapor. SECTION III FIRE AND EXPLOSION DATA Describes at what temperature the chemical ignites, called the flash point. Flammable chemicals ignite below 100F while combustible chemicals ignite at 100F or above. This section also lists extinguishing media - what will put the fire out safely - such as water spray, foam, etc.. SECTION IV REACTIVITY DATA Describes whether the chemical reacts with other materials or under specific conditions. Incompatibility lists the materials, such as water or other chemicals, that cause the chemical to bum, explode, or release dangerous gases. Instability lists the environmental conditions, such as heat or direct sunlight, that cause a dangerous reaction. Hazardous decomposition products that evolve when the material is involved in fire are listed, as well as whether or not hazardous polymerization will or will not occur. SECTION V ENVIRONMENTAL, SPILL, LEAK, DISPOSAL PROCEDURES Describes the materials and practices that are to be used to control or clean up accidental spills and releases. This DO A 060498 CONFIDENTIAL DOW CHEMICAL LAD SOLVENTS / EDC 1 OSHA HAZARD COMMUNICATION MANUAL CFR29 1910.1200 INTERPRETING MATERIAL SAFETY DATA SHEETS section also includes information on proper disposal procedures. SECTION VI HEALTH HAZARD DATA Describes symptoms of overexposure, such as skin rash, burn, headache, or dizziness. Also, describes the hazards associated with eye contact, skin contact, ingestion, and inhalation. SECTION VII FIRST AID Describes actions to be taken when harmful contact with the chemical has occurred such as flushing skin that has been exposed with water for 15 minutes. It also may list any medical conditions that can be aggravated or accelerated by exposure to the chemical. Additionally, there may be special directions for doctors or emergency medical technicians involved in treatment of overexposure victims. SECTION VIII HANDLING PRECAUTIONS Describes protective equipment for the eyes, skin, and respiratory tract needed to work safely with the chemical. Also list agency exposure limits such as the OSHA Permissible Exposure Limit. SECTION IX ADDITIONAL INFORMATION Describes regulatory information, such as the SARA Hazard Category, whether it is an immediate or delayed health hazard (or both), and special precautions to be taken for handling or storage. In addition to the above information, there are other resources available to aid in the understanding of the valuable information presented in the MSDS. The Plant Environmental Coordinator, Supervisors, and the Technical Staff may also be contacted in an effort to interpret data pertaining to the chemicals you work with. 2 DO A 060499 CONFTDFNTTAl DOW CHEMICAL LAD SOLVENTS / EDC 1 OSHA HAZARD COMMUNICATION MANUAL CFR29 1910.1200 MATERIAL SAFETY DATA SHEET DEFINITIONS The following is a glossary of terms which may be found in a MSDS. Acute Having the character of being single, of short duration, or of high intensity. As -- a single oral dose; a short single vapor exposure probably lasting no more than 8 hours; a sudden effect. ACGIH American Conference of Governmental Industrial Hygienist, Executive Secretary, P.0. Box 1937, Cincinnati, Ohio, 45201 Adverse Effect Any harmful change from the normal response to a stimulus. Aerosol A suspension of extremely fine solid particles or liquid droplets in gas, usually air. Allergy The acquired state of being sensitized to a specific material. Involves an immunological response to a sensitizing material where reexposure reveals an altered capacity to react. Ames Test A mutagenicity test using bacteria. If a mutation is caused by the test substance, many bacterial will be able to grow in a nutrient deficient media. Antibodies Any of the body globulins that combine specifically with antigens and neutralize toxins. Asphyxiant A substance, usually a gas, that can cause the loss of consciousness or even death as a result of too little oxygen or to much carbon dioxide in the blood. Benign Of a mild character; not malignant; non-cancerous. Bronchial tubes The tubes of the respiratory tract branching from the trachea to the lungs. 3 DO A 060500 C0NFTDFNTTAL DOW CHEMICAL LAD SOLVENTS / EDC 1 OSHA HAZARD COMMUNICATION MANUAL CFR29 1910.1200 MATERIAL SAFETY DATA SHEET DEFINITIONS Bronchitis An inflammation of the mucous lining of the bronchial tubes. Carcinogenic A substance capable of producing carcinoma (cancer). Carcinogenesis The initiation of uncontrolled tissue growth. Cardiac Pertaining to the heart. Ceiling The maximum amount of a material to which any employee can be exposed, even instantaneously, without proper protective equipment. Chloracne A skin disorder that can be induced by chlorinated chemicals, characterized by blackheads. Cholinesterase An enzyme that stops nerves from "firing". Cholinesterase Inhibitor A substance that keeps cholinesterase from working. Chronic Usually comprising the majority of lifetime test animals over 1 to 2 years in rodents. Constant, lasting for a long time; recurring. Cornea The transparent part of the covering of the eyeball. CNS Central Nervous System Dermal The name given to a study in which a substance is repeatedly applied to the skin of an animal for weeks to months to determine whether absorption takes place to a great degree enough to cause toxicity. Dermatitis Inflammation of the skin. 4 DO A 060501 CONFIDENTIAL. DOW CHEMICAL LAD SOLVENTS / EDC 1 OSHA HAZARD COMMUNICATION MANUAL CFR29 1910.1200 MATERIAL SAFETY DATA SHEET DEFINITIONS Dominant Lethal Male rodent exposed to test chemical for 3 months then mated with 2 untreated females, number of live eggs vs. eggs released give indication of mutation causing mortality to fertilized eggs. Dyspnea Difficult or labored respiration. Edema Swelling. Effect Any change from a normal response to some stimulus; it may be desirable or undesirable. Emphysema A pathological accumulation of air in the lungs; the inability to completely exhale. Epidemiology The study of disease as it spreads and involves large groups of people. Epithelium Cellular tissue that covers surfaces, forms glands, and lines most cavities of the body. Erythema Redness. Evaporation Rate The ratio of the time required to evaporate a measured volume of liquid to the time required to evaporate the same volume of a reference liquid (ethyl ether) under ideal test conditions. The higher the ratio, the slower the evaporation rate. Exfoliation Peeling or flaking of the skin. Flash point The minimum temperature at which a liquid will generate sufficient flammable vapors to ignite. Gastrointestinal Stomach plus intestines. 5 00 A 060502 CONFIDENTIAL DOW CHEMICAL LAD SOLVENTS / EDC 1 OSHA HAZARD COMMUNICATION MANUAL CFR29 1910.1200 MATERIAL SAFETY DATA SHEET DEFINITIONS Genetic Related to DNA - chromosomes, genes. Half-life The time required to get rid of half of a given dose of a substance. Hazard The potential for causing harm. For chemicals, hazard equals toxicity times exposure. Hematologic Referring to the blood. Hepatic Referring to the liver. Hyper- Increased over normal. Hyperemia Redness. Hypo- Decreased below normal, i.m. Intramuscular - into the muscle. Inhibition A reduction in the rate of reaction; rate may be reduced to zero. Innocuous Cannot injure or harm; harmless, i.p. Intraperitoneal - within the abdominal cavity but outside the organs. In vitro "In glass" - in a test tube; outside the animal. In vivo Inside the animal. 6 00 A 060503 confidential DOW CHEMICAL LAD SOLVENTS / EDC 1 OSHA HAZARD COMMUNICATION MANUAL CFR29 1910.1200 MATERIAL SAFETY DATA SHEET DEFINITIONS Irreversible Effect One which can be characterized and measured and which persists indefinitely after the stress has been removed. Iris The opaque contractile diaphragm perforated by the pupil and forming the colored portion of the eye. Irritant Any substance, not corrosive, that on immediate, prolonged, or repeated contact with normal living tissue will induce a local inflammatory reaction. i.v. Intravenous - into the veins. Lachrymator A substance that irritates the eyes and produces tears. LC5o Usually used for inhalation tests - that concentration of a vapor in air which causes the death of 50 % of a given population of animals - a statistically derived number stated with a fixed number (i.e. LC50 4 hours). ^50 " Lethal dose for 50 % of a given population of animals - a statistically derived number with any route of exposure. Lesion Any change in the cellular structure of a tissue. Long Term Exposure Term usually connoting exposures measured in months / years. Malignant Designating an abnormal growth that tends to metastasize, mg Milligrams; one thousandth of a gram; 0.000035 ounces. mg/m3 Milligrams per cubic meter - Airborne concentrations of particulate materials or mists expressed as milligrams of particulate per cubic meter of air. 7 DO A 060504 OONF TDFTNT TAL DOW CHEMICAL LAD SOLVENTS / EDC 1 OSHA HAZARD COMMUNICATION MANUAL CFR29 1910.1200 MATERIAL SAFETY DATA SHEET DEFINITIONS Mutagen A substance which causes a sudden variation of the offspring differing from its parents in some well-marked characteristic, due to changes within the chromosomes or genes. Mutation A relatively permanent change in hereditary material. Narcosis A reversible condition characterized by stupor or insensibility; unconsciousness. Necrosis Tissue death or a bum. NEL No-effect-level. That dose causing no adverse effects in chronic or sub-chronic tests. Neuro- Related to the nervous system. NOEL No-observed-effect-level. OSHA U. S. Department of Labor, Occupational Safety and Health Administration, 3rd Street and Constitution Ave., N. W., Washington, D.C. 20210 Parenteral Not intestinal. A route of dosing other than oral. Particulate Composed of fine droplets or particles. Parts per million The concentrations of gases and vapors usually expressed as parts per million parts of air (ppm) on a volumetric basis. Percent Volatile by Volume Refers to the percentage of liquid or solid that evaporates at room temperature. The higher the percentage, the faster the evaporation rate. 8 DO A 060505 CONFIDFNTTAl DOW CHEMICAL LAD SOLVENTS / EDC 1 OSHA HAZARD COMMUNICATION MANUAL CFR29 1910.1200 MATERIAL SAFETY DATA SHEET DEFINITIONS Percutaneous Through the skin. PEL OSHA's Permissable Exposure Limit - that concentration of a substance in the working environment which may be inhaled (encountered) by the majority of individuals, 8 hours/day, 5 days/week, for a working lifetime (35 years) with no adverse effects (same as the ACGIH TLV). Pharmacokinetics Study of the speed of metabolism - helps determine threshold dose (if any). p.o. 'Per Oral" - by mouth. Potentiation Greater than the additive toxicity of 2 substances. Pulmonary Edema Edema of the lungs wherein fluid accumulates in the aveoli (air sacs). Renal Referring to the kidney. Reproduction Test Males and females are dosed, effects on any reproductive parameters or any health effect on parents or young are determined. May take 1 to 3 generations to study. Respirable Capable of being taken in by breathing. Reversible Effects One which can be characterized and measured, but which does not persist after the stress has been removed. S.C. Subcutaneous - under the skin. Sensitivity The magnitude of a normal reaction to a substance - not an allergic response. 9 ^0 a 060506 CONFrOFNT JAi DOW CHEMICAL LAD SOLVENTS / EDC 1 OSHA HAZARD COMMUNICATION MANUAL CFR29 1910.1200 MATERIAL SAFETY DATA SHEET DEFINITIONS Solubility Refers to the percentage by weight which can be dissolved in a media (usually water). Specific Gravity The ratio of the weight of a volume of liquid to the weight of an equal volume of water (water = 1). STEL Short Term Exposure Levels, in relation to Threshold Limit Values. The short term limit of exposure without the aid of respiratory protection. Subacute Intermediate between acute and chronic; a repeated dosing over a period of days or weeks. Sub-chronic Repeated dosing, more than 1 dose to tests lasting up to 1 year. Susceptibility The state of being subjected to the influence of some stimulus or stress. Symptom Any Evidence of a change from the normal which is manifest subjectively. Synergism A more than additive effect of 2 substances which have the same type of effect (i.e. - asbestos and cigarettes). Systemic Effect Remote as opposed to local effect at the site of contact. Target Organ The primary organ affected by dosing with a test substance. Teratogen A substance, form of energy, or disease, imposed at a level which produces a permanent functional or anatomic abnormality in the developing organism "in utero"; causes birth defects. 10 DO A 060507 CONFIDENTIAL DOW CHEMICAL LAD SOLVENTS / EDC 1 OSHA HAZARD COMMUNICATION MANUAL CFR29 1910.1200 MATERIAL SAFETY DATA SHEET DEFINITIONS Threshold dose The amount of a substance which uses up 100 % of the body's primary defense system. Not possible to determine exactly. TLV Threshold Limit Value - that concentration of a substance in the working environment which may be inhaled (encountered) by the majority of individuals, 8 hours/day, 5 days/week, for a working lifetime (35 years) with no adverse effects. Toxic Hazard The probability of toxicity occurring under stated circumstances. Toxicity A property of a substance to produce injury by other than physical means. Tumor An abnormal mass of tissue. May or may not be cancerous. TWA Time Weighted Average - exposure for a normal work day in relation to TLV. Vapor Pressure Pressure exerted by a vapor. The higher the vapor pressure the, the easier a material will evaporate. Vascular Pertaining to the vessels in the body which convey blood or lymph. MB:1291 11 roK A 06S08 confidential