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AR226-1397 (snauw um E. I. d u P o n t de N e m o u r s & C o m p a n y IM COItPOIIATCO W il m in g t o n . D ela w a r e 19898 CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT HASKELL LABORATORY FO TOXICOLOGY AND INDUSTRIAL MEDICINE bcc : C. F. Rexnhardt/B. C. McKusick J. W. Raines - PPD - M-5625 S. G. Hundley/R. W. Hartgrove R. E. Staples H. J. Trochimowicz/J. G. Aftosmis d -?// A* a.8.6 _ /397 March 16, 1982 Dr. Joseph Seifter TS-792 Office of Toxic Substances U. S. Environmental Protection Agency 401 "M" Street, S.W. Washington, D.C. 20460 Dear Dr. Seifter: We have studied the placental transfer of ^4C-perfluorooctanoate (C-8) in the albino rat by orally administering the \ chemical on Gestation Day 19 and following maternal blood and fetal tissue levels of the radiocarbon at 2, 4 , and 8 hours after dosing. Maternal blood and placental levels of 14 c in creased between 2 and 4 hours then decreased between 4 and 8 hours after dosing. The yg equivalents in maternal blood were approximately 1 2 , 20 and 12 yg/ml at 2, 4 , and 8 hours post dosing, respectively. Corresponding fetal levels (whole body assays) were 0 . 7 , 3, and 3 yg/ml. These data demonstrate that 14C-labelled C-8 does transfer across the placenta of the rat. Please call me (302-366-5259) if you have any further questions. Sincerely, GLK:scg & .w t j Q Gerald L. Kennedy, J r . Section Supervisor, Acute Investigations BETTER T H IN G S PO R B E TT ER LIVING . . . THROUGH CHEM ISTRY EID071704 c c c