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AR226-3187 DuPont-4739 TRADE SECRET Study Title H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Volume 4 of 5 Laboratory Project ID: DuPont-4739 TEST GUIDELINES: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100 (1998) AUTHOR: Don A. Delker, Ph.D. STUDY COMPLETED ON: October 23, 2001 PERFORMING LABORATORY: E.I. du Pont de Nemours and Company Haskell Laboratory for Health and Environmental Sciences Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 WORK REQUEST NUMBER: smiji SERVICE CODE NUMBER: UJjjjijjjj^ SPONSOR STUDY NUMBER: ^ ^saWssssa. Does 908 wW^ w^ ^ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 APPENDIX L (CONTINUED) INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS 938 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic Sc Macroscopic Findings 641234 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM. MESENTERIC LYMPH NODE, SALIVARY GLAMDS, MAMDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA. ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAMD (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM. NOSE Histopathology : LIVER : INFLAMMATION, THYROID GLAND : SUBACUTE/CHRONIC, " . minimal. ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal. No Microscopic Abnormality Observed : NOSE 939 Company SSanfteed, Does not contain TSCA Ct H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641237 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS. MAMDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATI ON, THYROID GLAND : SUBACUTE/CHRONIC, min imal. ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. PARATHYROID GLANDS : NOT PRESENT. UTERUS : DILATATION, LUMEN, minimal. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. 641237 Continued on the next page .... 940 cwasw|ySmm^Q^a.DoBs^ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII Animal Ref 1000 mg/kg/day Sex: Females Microscopic & Macroscopic Findings 641237 Continued from previous page Histopathology No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 641256 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS,' HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 641256 Continued on the next page 941 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 nig/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641256 Continued from previous page Hisfcopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : NOSE 641259 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 641259 Continued on the next page .... 942 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641259 Continued from previous page Histopathology : LIVER : INFLAMMATION, FATTY CHANGE, SUBACUTE/CHRONIC, minimal. MEDIAN CLEFT, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE 641264 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS; MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : 641264 LIVER : INFLAMMATION, SUBACUTE/CHRONIC, Continued on the next page .... minimal. 943 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations _DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641264 Continued from previous page Histopathology : THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal. No Microscopic Abnormality Observed : NOSE 641275 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : 641275 LIVER : PATTY CHANGE, MEDIAN CLEFT, Continued on the next page .... minimal. 944 CSemptsnySanitized. Does not cemtefn TS-^5, '?.' H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations _________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641275 Continued from previous page Histopathology : LIVER : INFLAMMATION, LUNGS : SUBACUTE/CHRONIC, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. PARATHYROID GLANDS : NOT PRESENT. UTERUS : DILATATION, LUMEN, mild. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. No Microscopic Abnormality Observed : KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 945 f e'wta'iyi fiy^ y .,,, H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V3[II - 1000 mg/kg/day Sex: Pemclies Animal Ref Microscopic & Macroscopic Findings 641278 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MAMDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAMD, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : NOSE 946 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641279 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, mild. PARATHYROID GLANDS : NOT PRESENT. minimal. 641279 Continued on the next page 947 Company. S a n f f i z e d . H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641279 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, . SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN. MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 641282 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS,- HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, MOSE 641282 Continued on the next page .... 948 Gompanysantecl-^"ote^InTSc^. H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641282 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. No Microscopic Abnormality Observed : NOSE 641299 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : SPLEEN : DISCOLORATION, BROWN. 641299 No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Continued on the next page .... 949 ISssspesy SanKbeed. Does not contain TSC&: . Doe nn ---. - H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex; Females Animal Ref Microscopic & Macroscopic Findings 641299 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR, mild. ALTERATION, COLLOID, minimal. UTERUS : DILATATION, LUMEN, minimal. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 950 .".is iar;fl if H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations . DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641300 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHROWIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. PARATHYROID GLANDS : NOT PRESENT. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild. 641300 Continued on the next page .... 951 Beg T^-fl ecntetr; 7'^C'A CBt Company SanKbeA Does net een?a?n Ti H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641300 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, KIDNEYS, STOMACH, DUODENUM, JEJUNUM, ILEUM, BRAIN, SPINAL CORD. PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 641301 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality LIVER, KIDNEYS, LUNGS, Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORCDO, LOSTNO, MRAECCHT, UMDU, OMDEENSUEMN,TEJREICJUNLUYMMP, H NILOEDUEM, , SPAALNIVCARREYASG, LCAENCDUSM, , MANDIBULAR LYMPH NODE. THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 641301 Continued on the next page .... 952 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641301 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE 641314 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : 641314 LIVER : INFLAMMATION, SUBACUTE/CHRONIC, Continued on the next page .... minimal. 953 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641314 Continued from previous page Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM. COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MAMDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 641326 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : 641326 No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM,. ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, Continued on the next page .... 954 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641326 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. PARATHYROID GLANDS : NOT PRESENT. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH MODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAMD, TRACHEA, ESOPHAGUS, PHARYMX/LARYMX, EYE(S) WITH OPTIC MERVE, SKIN, MAMMARY GLAMD (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, MOSE 955 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations . DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641327 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, FATTY CHANGE, THYROID GLAND : SUBACUTE/CHRONIC, minimal. MEDIAN CLEFT, minimal. ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR. minimal. PARATHYROID GLANDS : NOT PRESENT. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. 641327 Continued on the next page .... 956 S'ompany Sanlfifced. H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 ing/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641327 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 641352 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 641352 Continued on the next page .... 957 Company SanS8Sz@d.Does not conWn TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641352 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE 641356 Found Dead Duration of dosing-days: 121 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID-GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopafchology : BRAIN : MIXED GLIOMA [M]. [B]=BENIGN, [M]=MALIGNANT 641356 Continued on the next page .... 958 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641356 Continued from previous page Histopathology : ILEUM : AUTOLYSIS NECROPSY AND CECUM : AUTOLYSIS NECROPSY AND COLON : AUTOLYSIS NECROPSY AND THYROID GLAND AUTOLYSIS NECROPSY AND EYE(S) WITH OPTIC NERVE : AUTOLYSIS NECROPSY AND SKIN : NOT PRESENT. MAMMARY GLAND (FEMALE) : NOT PRESENT. HISTOLOGY HISTOLOGY HISTOLOGY HISTOLOGY HISTOLOGY PERFORMED. PERFORMED. PERFORMED. PERFORMED. PERFORMED. No Microscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA. SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, PANCREAS, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 959 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ret Microscopic & Macroscopic Findings 641366 Terminal Sacrifice Killed on Day : 123 Exposure Group ; RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS. HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND. PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, NECROSIS, FOCAL, minimal. minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE 960 A. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641377 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN. AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM. COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH MODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, FATTY CHANGE, THYROID GLAND : SUBACUTE/CHRONIC, minimal, MEDIAN CLEFT, minimal. ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. No Microscopic Abnormality Observed : NOSE 961 Company Sanitized. Does not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641380 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : Ho Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE. SALIVARY GLANDS, MAMDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE. PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS. TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : 641380 LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HEART : CARDIOMYOPATHY, minimal. SCIATIC NERVE : NOT PRESENT. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. PARATHYROID GLANDS : NOT PRESENT. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, Continued on the next page .... mild. 962 Company Sanitized. Does nos conWn TSCA! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641380 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 641385 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS,' HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 641385 Continued on the next page .... 963 Company Sanitized. Does not contain TSCA CBi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ret Microscopic & Macroscopic Findings 641385 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAMD : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : NOSE 641387 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, . COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 641387 Continued on the next page .... 964 toflpany Sanitized, Does not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641387 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. No Microscopic Abnormality Observed : NOSE 641390 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM. NOSE 641390 Continued on the next page .... 965 H-24616: Subchronic Toxicity 90-Day Gavage Study inRats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641390 Continued from previous page Histopathology : LIVER : INFLAMMATION. SUBACUTE/CHRONIC, minimal. KIDNEYS : INFLAMMATION. SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, mild. PARATHYROID GLANDS : NOT PRESENT. EYE(S) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 966 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641395 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER. KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM. MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS. TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, FATTY CHANGE, THYROID GLAND : SUBACUTE/CHRONIC, minimal. MEDIAN-CLEFT, mild. ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 967 H-24616: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 ing/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641399 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC MERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE. SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, mild. minimal. No Microscopic Abnormality Observed : NOSE 968 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 APPENDIX M REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHTS OF Pi MALE RATS 969 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________DuPont-4739 REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHTS OF Pi MALE RATS EXPLANATORY NOTES Notes: Test Days 71-85 = Cohabitation period 970 GesBpanySanfIbed. H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OP Pi MALE RATS GROUP: '1-0 DOSE: 0 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 641114 641217 641204 641158 641100 641060 641188 641106 641175 641079 641125 641186 641052 641140 641135 641174 641107 641072 641053 641168 71 78 85 92 100 660 .5 568 .4 500 .1 547 .1 495 .4 651 .9 501 .5 547 .3 528 .5 464 .4 638 .4 521 .5 529 .2 653 .6 494 .6 492 .4 517 .3 495 .1 569 .3 527 .7 668 .9 592 .7 508 .7 562 .3 507 .2 684 .7 510 .9 568 .1 541 .7 484 .6 655 .5 540 .4 535 .1 665 .6 500 .9 508 .8 518 .4 501 .2 584 .3 537 .8 685 .4 597 .2 513 .9 579 .1 518 .6 697 .4 520 .0 574 .7 552 .7 490 .8 671 .2 558 .5 545 .6 686 .7 512 .5 515 .6 534 .1 510 .0 597 .1 552 .6 675 .2 595 .7 520 .3 594 .4 531 .5 719 .1 528 .4 589 .4 561 .5 501 .0 696 .9 572 .9 558 .8 706 .5 535 .1 528 .5 556 .7 512 .7 600 .5 561 .0 681 .6 588 .8 522 .2 614 .3 533 .5 736 .4 532 .6 606 .1 560 .1 502 .9 716 .1 589 .1 563 .0 714 .0 536 .0 534 .2 568 .0 527 .6 633 .6 573 .5 971 ci. Bties not contain TSR& ^ H-24616: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Pi MALE RATS GROUP: III-O DOSE: 50 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 641087 641108 641118 641128 641091 641199 641209 641163 641.129 641138 641103 641181 641171 641111 641062 641156 641173 641121 641074 641191 71 78 85 92 100 555 .4 501 .6 559 .5 572 .0 459 .2 563 .5 482 .5 484 .7 516 .8 534 .7 622 .9 559 .6 598 .6 515 .3 524 .2 576 .3 556 .4 524 .6 582 .5 570 .1 583 .1 451 .6 567 .0 586 .5 464 .5 563 .3 508 .1 497 .9 522 .4 548 .3 616 .3 579 .2 617 .5 522 .0 536 .6 587 .9 563 .9 552 .9 600 .3 569 .2 594 .2 495 .0 577 .3 597 .4 484 .3 564 ,5 513 .9 502 .5 538 .4 554 .7 627 .7 584 .5 622 .4 524 .3 539 .7 607 .9 574 .3 557 .9 610 .3 562 .3 610 .7 520 .3 602 .6 595 .8 498 .3 578 .3 507 .5 497 .6 546 .1 563 .1 647 .1 597 .2 640 .6 532 .1 551 .1 620 .3 592 .7 575 .1 569 .0 568 .7 609 .3 537 .2 604 .2 596 .6 507 .7 591 .1 518 .2 505 .1 560 .3 573 .9 651 .3 598 .4 652 .5 523 .5 560 .3 619 .0 601 .9 592 .2 600 .9 572 .7 972 Sanitized. Ooes not contain TSCA C H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OP Pi MALE RATS GROUP: V-0 DOSE: 250 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 641170 641065 641126 641058 641131 641176 641119 641075 641180 641117 641124 641082 641151 641195 641122 641184 641142 641120 641179 641164 71 78 85 92 100 578 .9 506 .7 495 .0 454 .3 504 .0 531 .1 581 .3 532 .0 528 .0 579 .0 594 .3 486 .3 519 .8 550 .3 538 .9 505 .4 476 .4 603 .5 583 .4 560 .1 600 .0 535 .8 474 .0 459 .6 526 ,7 546 .6 605 .5 546 .3 541 .5 606 .9 601 .6 493 .5 528 .2 565 .6 551 .0 514 .5 478 .6 612 .3 604 .1 576 .5 614.0 543.1 483.9 477.0 524.3 542.4 601.7 565.9 544.2 610.9 618.3 499.8 538.5 576.8 558.7 524.5 476.4 630.1 605.0 593.3 639 .4 558 .6 501 .7 478 .1 531 .9 552 .4 617 .4 566 .3 564 .8 626 .7 636 .2 507 .3 547 ,3 590 .3 553 .5 520 .3 487 .5 641 .7 620 .7 613 .1 641.1 565.1 522.9 483.8 523.5 564.2 612.7 559.4 579.2 643.6 652.6 514.7 562.9 599.6 565.4 517.2 502.6 647.2 648.9 622.3 973 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations , DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Pi MALB RATS GROUP: VII-0 DOSE: 1000 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 641110 641096 641212 641068 641093 641054 641208 641193 641207 641139 641080 641078 641177 641112 641210 641152 641182 641150 641211 641145 71 78 85 92 100 558 .4 449 .6 459 .6 458 .1 445 .9 528 .2 402 .4 519 .9 549 .8 489 .9 498 .2 497 .1 589 .1 510 .7 563 .7 468 .7 447 .7 433 .5 430 .4 494 .7 567 .9 458 .8 476 .0 465 .2 455 .9 536 .3 402 .5 532 .5 557 .9 497 .2 495 .9 521 .1 621 .4 527 .2 579 .0 491 .8 451 .9 442 .4 446 .8 518 .6 556 .4 479 .1 483 .5 462 .6 470 .5 544 .9 408 .4 534 .6 571 .1 503 .1 514 .8 522 .5 639 .1 547 .3 535 .5 500 .4 459 .0 441 .3 455 .2 504 .2 565 .8 489 .6 487 .6 469 .2 491 .6 564 .0 420 .3 550 .3 589 .2 504 .5 522 .7 535 .5 642 .3 554 .9 564 .1 517 .6 474 .9 461 .9 465 .8 519 .7 592 .1 498 .1 501 .5 476 .8 501 .7 557 .8 409 .0 558 .1 592 .2 520 .2 529 .8 524 .9 646 .3 571 .6 583 .7 525 .9 480 .5 463 .1 473 .6 526 .8 974 Company Sanffized. Does na8 conSaIn' H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________DuPont-4739 APPENDIX N REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHT GAINS OF Pi MALE RATS 975 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHT GAINS OF Pi MALE RATS EXPLANATORY NOTES Notes: Test Days 71 - 85 = Cohabitation period 976 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OP Pi MALE RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 641114 641217 641204 641158 641100 641060 641188 641106 641175 641079 641125 641186 641052 641140 641135 641174 641107 641072 641053 641168 71-78 78-85 85-92 92-100 71-100 8 .4 24 .3 8 .6 15 .2 11 .8 32 .8 9 .4 20 .8 13 .2 20 .2 17 .1 18 .9 5 .9 12 .0 6 .3 16 .4 1 .1 6 .1 15 .0 10 .1 16 .5 4 .5 5 .2 16 .8 11 .4 12 .7 9 .1 6 .6 11 .0 6 .2 15 .7 18 .1 10 .5 21 .1 11 .6 6 .8 15 .7 8 .8 12 .8 14 .8 -10 .2 -1 .5 6 .4 15 .3 12 .9 21 .7 8 .4 14 .7 8 .8 10 .2 25 .7 14 .4 13 .2 19 .8 22 .6 12 .9 22 .6 2 .7 3 .4 8 .4 6 .4 -6 .9 1 .9 19 .9 2 .0 17 .3 4 .2 16 .7 -1 .4 1 .9 19 .2 16 .2 4 .2 7 .5 0 .9 5 .7 11 .3 14 .9 33 .1 12 .5 21 .1 20 .4 22 .1 67 .2 38 .1 84 .5 31 .1 58 .8 31 .6 38 .5 77 .7 67 .6 33 .8 60 .4 41 .4 41 .8 50 .7 32 .5 64 .3 45 .8 977 H-24616; Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi MALE RATS GROUP: III-O DOSE: 50 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 641087 641108 641118 641128 641091 641199 641209 641163 641129 641138 641103 641181 641171 641111 641062 641156 641173 641121 641074 641191 71-78 78-85 85-92 92-100 71-100 27 .7 50 .0 7 .5 14 .5 5 .3 -0 .2 25 .6 13 .2 5 .6 13 .6 -6 .6 19 .6 18 .9 6 .7 12 .4 11 .6 7 .5 28 .3 17 .8 -0 .9 11 .1 43 .4 10 .3 10 .9 19 .8 1 .2 5 .8 4 .6 16 .0 6 .4 11 .4 5 .3 4 .9 2 .3 3 .1 20 .0 10 .4 5 .0 10 .0 -6 .9 16 .5 25 .3 25 .3 -1 .6 14 .0 13 .8 -6 .4 -4 .9 7 .7 8 .4 19 .4 12 .7 18 .2 7 .8 11 .4 12 .4 18 .4 17 .2 -41 .3 6 .4 -1 .4 16 .9 1 .6 0 .8 9 .4 12 .8 10 .7 7 .5 14 .2 10 .8 4 .2 1 .2 11 .9 -8 .6 9 .2 -1 .3 9 .2 17 .1 31 .9 4 .0 53 .9 35 .6 44 .7 24 .6 48 .5 27 .6 35 .7 20 .4 43 .5 39 .2 28 .4 38 .8 53 .9 8 .2 36 .1 42 .7 45 .5 67 .6 18 .4 2 .6 978 SanHbed. Does not contain TSCA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi MALE RATS GROUP: V-0 DOSE: 250 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 641170 641065 641126 641058 641131 641176 641119 641075 641180 641117 641124 641082 641151 641195 641122 641184 641142 641120 641179 '641164 71-78 78-85 85-92 92-100 71-100 21 .1 29 .1 21 .0 5 .3 22 .7 15 .5 24 .2 14 .3 13 .5 27 .9 7 .3 7 .2 8 .4 15 .3 12 .1 9 .1 2 .2 8 .8 20 .7 16 .4 14 .0 7 .3 9 .9 17 .4 -2 .4 -4 .2 -3 .8 19 .6 2 .7 4 .0 16 .7 6 .3 10 .3 11 .2 7 .7 10 .0 -2 .2 17 .8 0 .9 16 .8 25 .4 15 .5 17 .8 1 .1 7 .6 10 .0 15 .7 0 .4 20 .6 15 .8 17 .9 7 .5 8 .8 13 .5 -5 .2 -4 .2 11 .1 11 .6 15 .7 19 .8 1 .7 6 .5 21 .2 5 .7 -8 .4 11 .8 -4 .7 -6 .9 14 .4 16 .9 16 .4 7 .4 15 .6 9 .3 11 .9 -3 .1 15 .1 5 .5 28 .2 9 .2 62 .2 58 .4 27 .9 29 .5 19 .5 33 .1 31 .4 27 .4 51 .2 64 .6 58 .3 28 .4 43 .1 49 .3 26 .5 11 .8 26 .2 43 .7 65 .5 62 .2 979 SSwsspmjSanitized. Does noteonSaIn TSCA CB't H-24616: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OP Pi MALE RATS GROUP: VII-0 DOSE: 1000 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 641110 641096 641212 641068 641093 641054 641208 641193 641207 641139 641080 641078 641177 641112 641210 641152 641182 641150 641211 641145 71-78 78-85 85-92 92-100 71-100 9 .5 9 .2 16 .4 7 .1 10 .0 8 .1 0 .1 12 .6 8 .1 7 .3 -2 .3 24 .0 32 .3 16 .5 15 .3 23 .1 4 .2 8 .9 16 .4 23 .9 -11 .5 20 .3 7 .5 -2 .6 14 .6 8 .6 5 .9 2 .1 13 .2 5 .9 18 .9 1 .4 17 .7 20 .1 -43 .5 8 .6 7 .1 -1 .1 8 .4 -14 .4 9 .4 10 .5 4 .1 6 .6 21 .1 19 .1 11 .9 15 .7 18 .1 1 .4 7 .9 13 .0 3 .2 7 .6 28 .6 17 .2 15 .9 20 .6 10 .6 15 .5 26 .3 8 .5 13 .9 7 .6 10 .1 -6 .2 -11 .3 7 .8 3 .0 15 .7 7 .1 -10 .6 4 .0 16 .7 19 .6 8 .3 5 .6 1 .2 7 .8 7 .1 33 .7 48 .5 41 .9 18 .7 55 .8 29 .6 6 .6 38 .2 42 .4 30 .3 31 .6 27 .8 57 .2 60 .9 20 .0 57 .2 32 .8 29 .6 43 .2 32 .1 980 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations __________DuPont-4739 APPENDIX 0 REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHTS OF Pi FEMALE RATS DURING GESTATION 981 Sanltod. Does ^ ^^ ^A CB8 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS DuPont-4739 INDIVIDUAL BODY WEIGHTS OF Pi FEMALE RATS DURING GESTATION EXPLANATORY NOTES Footnotes a Dam delivered prior to collection of day 21 body weight. b No litter was delivered; data were excluded from statistical analysis. c No gestation data were collected since no plug was observed; however, a litter was delivered. d No gestation data were collected since no plug was observed; no litter was delivered. Abbreviations -- = No Data 982 Company SanKSreA Does not contain TSCA CBB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Pi FEMALE RATS DURING GESTATION GROUP: II-O DOSE: 0 MG/KG/DAY GESTATION DAY'S: ANIMAL NUMBER 641345 641236 641337 641328 641310 641324 641371 641332 641358^ 641389^ 641317C 641255 641403 641388 641261 641306 641349G 641346 641308 641289 14 21 277.4 294.9 324.8 325.8 274.0 288.1 322.6 331.2 300.7 297.7 302.8 319.2 354.2 287.5 289.3 32-1-.8- 281.7 300.8 289.9 330.3 356.9 352.1 309.6 318.0 345.4 360.4 309.2 309.9 327.2 362.1 376.0 310.4 329.8 35-9-.8- 306.4 330.4 309.3 366.7 383.8 381.6 331.5 350.2 380.0 405.4 314.4 317.2 347.7 395.8 425.9 339.9 356.1 38-2-.0- 342.6 366.9 ---a 461.3 450.2 455.0 430.1 438.3 484.2 498.0 311.7 314.9 447.4 507.4 ---a 420.6 450.4 47-3-.5- 419.0 441.5 983 Company SanHized. QO&B not conlain TSCA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF PI FEMALE RATS DURING GESTATION GROUP: IV-0 DOSE: 50 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 641378 641263 641297 641304 641274> 641351 641272 641258 641276^ 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 14 21 336 .0 278 .3 311 .4 315 .9 350 .5 276 .4 290 .4 339 .7 376 .6 292 .7 292 .3 310 .4 335 .2 286 .1 283 .6 308 .5 330 .4 298 .0 388 .0 306 .9 372 .8 298 .0 347 .8 347 .7 362 .8 293 .1 317 .5 362 .5 393 .4 306 .8 313 .6 337 .9 350 .7 316 .9 320 .5 322 .9 366 .7 325 .0 422 .7 339 .8 405 .4 326 .3 378 .7 365 .3 363 .2 320 .2 346 .3 393 .1 411 .5 339 .9 331 .8 364 .9 386 .3 342 .3 353 .0 342 .7 405 .1 357 .0 461 .3 368 .8 512 .7 410 .0 483 .9 460 .8 367 .2 421 .4 437 .9 -a - 401 .2 442 .4 390 .8 469 .8 471 .0 429 .6 441 .2 430 .1 517 .5 441 .3 532 .9 457 .4 984 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Pi FEMALE RATS DURING GESTATION GROUP: VI-0 DOSE: 250 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 641271 641280^ 641252^ 641386^' 641277 641233 641238 641235 641392 641360 641381^ 641333d 641239 641228^ 641334 641347 641367^ 641303 641339 641316 14 21 299 .7 282 .6 311 .4 288 .3 318 .8 311 .3 298 .4 253 .8 310 .2 273 .2 334 .3 333 .1 334 .9 285 .0 315 .2 350 .5 286 .2 321 .0 293 .1 319 .4 313 .4 326 .0 315 .8 352 .5 343 .5 312 .7 282 .8 327 .8 297 .8 351 .5 353 .3 361 .6 314 .6 351 .3 340 .1 308 .0 349 .0 319 .2 346 .3 340 .2 320 .1 338 .6 390 .5 386 .4 345 .4 304 .4 364 .3 323 .2 361 .2 386 .0 389 .4 342 .4 394 .3 350 .5 329 .0 378 .0 349 .3 448 .1 334 .2 328 .2 317 .6 489 .0 480 .7 438 .2 362 .1 440 .3 408 .3 363 .3 487 .2 387 .4 431 .7 490 .2 349 .5 417 .4 472 .4 443 .2 985 Company Sanitized. Does not contain TSCA GBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Pi FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 6412421 641284 641230 641273^ 641296 641248 641370 641243 641329 0 7 14 21 298 .6 291 .3 267 .6 264 .9 321 .2 256 .8 281 .2 274 .4 311 .5 348 .6 301 .9 343 .9 304 .4 279 .6 286 .7 279 .5 346 .4 310 .9 312 .0 264 .4 319 .8 312 .0 281 .4 279 .3 333 .2 292 .7 309 .5 297 .6 330 .6 369 .1 340 .9 336 .9 336 .5 297 .2 318 .6 295 .3 373 .1 337 .5 335 .4 281 .6 354 .7 349 .2 302 .5 311 .0 374 .7 328 .7 336 .6 317 .2 362 .1 411 .8 373 .2 346 .8 365 .3 325 .9 329 .4 329 .9 409 .0 370 .3 372 .3 313 .0 451 .3 443 .6 368 .9 390 .5 471 .9 406 .9 437 .4 405 .7 476 .1 522 .0 472 .8 346 .9 485 .1 408 .0 320 .0 421 .7 519 .2 444 .3 470 .0 409 .1 986 ecWHpanySanitized. Does not contain TSCA i H-24616: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 APPENDIX P REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHT GAINS OF Pi FEMALE RATS DURING GESTATION 987 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS OF Pi FEMALE RATS DURING GESTATION EXPLANATORY NOTES Footnotes a Dam delivered prior to collection of day 21 body weight. b No Utter was delivered; data were excluded from statistical analysis. c No gestation data were collected since no plug was observed; however, a litter was delivered. d No gestation data were collected since no plug was observed; no litter was delivered. Abbreviations -- = No Data 988 'Cempsny Sanitized. Does not eorrtain TSCA C^r H-24616: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproductive Evaluations____________DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi FEMALE RATS DURING GESTATION GROUP: II-O DOSE: 0 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 641345 641236 641337 641328 641310 641324 641371 641332 641358^ 641389^ 641317C 641255 641403 641388 641261 641306 641349C 641346 641308 641289 0-7 7-14 14-21 0-21 12.5 35.4 32.1 26.3 35.6 29.9 22.8 29.2 8.5 12.2 24.4 42.9 21.8 22.9 40.5 38.0 24.7 29.6 19.4 36.4 26.9 29.5 21.9 32.2 34.6 45.0 5.2 7.3 20.5 33.7 49.9 29.5 26.3 22.2 36.2 36.5 ___a 94.6 66.4 73.4 98.6 88.1 104.2 92.6 -2.7 -2.3 99.7 111.6 ___a 80.7 94.3 91.5 76.4 74.6 ___a 166.4 125.4 129.2 156.1 150.2 161.6 166.8 11.0 17.2 144.6 188.2 __-a 133.1 161.1 151.7 137.3 140.7 989 1. Doesi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi FEMALE RATS DURING GESTATION GROUP: IV-0 DOSE: 50 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 641378 641263 641297 641304 641274' 641351 641272 641258 641276^ 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 0-7 7-14 14-21 0-21 36 .8 19 .7 36 .4 31 .8 12 .3 16 .7 27 .1 22 .8 16 .8 14 .1 21 .3 27 .5 15 .5 30 .8 36 .9 14 .4 36 .3 27 .0 34 .7 32 .9 32 .6 28 .3 30 .9 17 .6 0 .4 27 .1 28 .8 30 .6 18 .1 33 .1 18 .2 27 .0 35 .6 25 .4 32 .5 19 .8 38 .4 32 .0 38 .6 29 .0 107 .3 83 .7 105 .2 95 .5 4 .0 101 .2 91 .6 - a - -10 .3 102 .5 59 .0 104 .9 84 .7 87 .3 88 .2 87 .4 112 .4 84 .3 71 .6 88 .6 176 .7 131 .7 172 .5 144 .9 16 .7 145 .0 147 .5 - --1 24 .6 149 .7 98 .5 159 .4 135 .8 143 .5 157 .6 121 .6 187 .1 143 .3 144 .9 150 .5 990 'Company SanlSteed. Does not contain TSCA H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi FEMALE RATS DURING GESTATION GROUP: VI-0 DOSE: 250 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 641271 641280-b 641252^' 641386^ 641277 641233 641238 641235 641392 641360 641381^ 641333d 641239 641228^ 641334 641347 641367^ 641303 641339 641316 0-7 19 .7 30 .8 14 .6 27 .5 33 .7 32 .2 14 .3 29 .0 17 .6 24 .6 17 .2 20 .2 26 .7 29 .6 36 .1 10 .4 21 .8 28 .0 26 .1 7-14 14-21 0-21 26 .9 26 .8 -5 .9 22 .8 38 .0 42 .9 32 .7 21 .6 36 .5 25 .4 9 .7 32 .7 27 .8 27 .8 43 .0 10 .4 21 .0 29 .0 30 .1 101 .8 -6 .0 8 .1 -21 .0 98 .5 94 .3 92 .8 57 .7 76 .0 85 .1 2 .1 101 .2 -2 .0 89 .3 95 .9 -1 .0 88 .4 94 .4 93 .9 148 .4 51 .6 16 .8 29 .3 170 .2 169 .4 139 .8 108 .3 130 .1 135 .1 29 .0 154 .1 52 .5 146 .7 175 .0 -1 .0 131 .2 151 .4 150 .1 991 i TSCA 'Compmy Sanffized. Does not contain T! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 641242^ 641284 641230 64127323 641296 641248 641370 641243 641329 0-7 7-14 14-21 0-21 21 .2 20 .7 13 .8 14 .4 12 .0 35 .9 28 .3 23 .2 19 .1 20 .5 39 .0 -7 .0 32 .1 17 .6 31 .9 15 .8 26 .7 26 .6 23 .4 17 .2 34 .9 37 .2 21 .1 31 .7 41 .5 36 .0 27 .1 19 .6 31 .5 42 .7 32 .3 9 .9 28 .8 28 .7 10 .8 34 .6 35 .9 32 .8 36 .9 31 .4 96 .6 94 .4 66 .4 79 .5 97 .2 78 .2 100 .8 88 .5 114 .0 110 .2 99 .6 0 .1 119 .8 82 .1 -9 .4 91 .8 110 .2 74 .0 97 .7 96 .1 152 .7 152 .3 101 .3 125 .6 150 .7 150 .1 156 .2 131 .3 164 .6 173 .4 170 .9 3 .0 180 .7 128 .4 33 .3 142 .2 172 .8 133 .4 158 .0 144 .7 992 , Does not contain TSCA w H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 APPENDIX Q REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHTS OF Pi FEMALE RATS DURING LACTATION 993 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______^______DuPont-4739 REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHTS OF Pi FEMALE RATS DURING LACTATION EXPLANATORY NOTES Footnotes i a No litter was delivered; therefore, no lactation data were collected. b Weighing error. Data excluded from statistical analysis. c Animal was found dead on lactation day 13. All pups were cannibalized before lactation day 7. Animal was excluded from statistical analysis. Abbreviations -- = No Data 994 H-24616; Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Pi FEMALE RATS DURING LACTATION GROUP: II-O DOSE: 0 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 641345 641236 641337 641328 641310 641324 641371 641332 6413583 641389s 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 14 21 295. 3 356. 4 394. 4 369. 9 313. 9 314. 5 367. 4 388. 7 357. 2 342. 1 372. 3 382. 5 333, 1 335. 4 354. 6 358. 3 308. 0 348. 3 292 .2 361 .0 362 .3 367 .0 299 .1 335 .9 354 .4 369 .3 358 .5 342 .9 378 .8 374 .0 339 .9 335 .3 353 .6 362 .2 320 .6 349 .9 315 .7 372 .3 361 .6 380 .7 350 .9 348 .8 344 .9 386 .8 359 .2 359 .3 420 .8 395 .3 346 .3 356 .5 393 .3 365 .3 346 .2 362 .3 293 .4 353 .9 354 .4 374 .2 317 .2 334 .7 334 .8 360 .2 360 .7 346 .8 389 .8 384 .5 335 .2 340 .0 361 .9 357 .6 340 .5 352 .4 995 "Company SanKbed. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Pi FEMALE RATS DURING LACTATION GROUP: IV-0 DOSE: 50 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 641378 641263 641297 641304 6412743 641351 641272 641258 6412763 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 14 21 373 .6 321 .8 376 .7 386 .1 317 .2 312 .4 340 .4 335 .1 312 .4 ----b 372 .7 328 .6 337 .8 328 .8 378 .5 340 .4 442 .6 354 .1 376 .7 328 .5 365 .8 341 .7 312 .9 332 .4 354 .7 328 .1 331 .3 360 .5 343 .0 306 .0 337 .3 321 .4 367 .6 335 .1 419 .9 336 .5 403 .9 345 .7 381 .7 355 .4 338 .5 328 .9 392 .3 356 .8 345 .1 376 .0 360 .4 326 .0 342 .1 340 .5 410 .8 351 .1 404 .5 357 .4 373 .5 323 .1 350 .7 339 .6 329 .3 308 .0 376 .5 335 .5 342 .6 366 .1 340 .7 318 .0 322 .7 340 .5 396 .7 349 .3 397 .1 346 .2 996 Company Sanitized. Does not eontain TSCA CB6 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Pi FEMALE RATS DURING LACTATION GROUP: VI-0 DOSE: 250 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 641271 641280a 6412523 6413863 641277 641233 641238 641235 641392C 641360 64138ia 6413333 641239 6412283 641334 641347 6413673 641303 641339 641316 0 7 14 21 329.0 348.4 355.5 343.1 392.8 361.1 333.4 301.4 342.6 299.7 368.5 301.0 360.8 315.7 353.4 331.1 377.8 351.8 318.1 302.0 329.3 322.8 369.8 321.9 374.2 321.0 381.3 348.1 379.7 374.8 342.6 322.6 338.3 378.4 343.5 385.6 325.6 389.0 341.2 355.4 356.9 324.0 319.1 326.7 388.2 324.0 361.0 318.0 367.5 353.8 997 Company SanHfeed. Boss not certain TCCA CM H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Pi FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 6412423 641284 641230 6412733 641296 641248 641370 641243 641329 0 7 14 21 339 .5 328 .3 297 .5 297 .1 373 .2 290 .3 326 .2 300 .4 376 .0 393 .6 343 .5 358 .9 320 .7 307 .9 401 .4 352 .8 363 .0 292 .6 351 .5 331 .3 300 .2 311 .2 362 .6 284 .7 286 .6 310 .9 364 .0 393 .6 347 .8 358 .9 313 .8 324 .3 390 .2 365 .0 353 .8 322 .7 378 .1 328 .1 312 .8 331 .7 384 .8 335 .4 337 .2 334 .9 379 .6 408 .0 375 .2 386 .0 321 .0 328 .9 391 .9 386 .3 363 .0 330 .2 360 .9 335 .0 300 .0 310 .7 367 .4 302 .3 320 .9 318 .3 349 .5 393 .3 355 .5 357 .6 318 .8 313 .1 355 .3 357 .2 374 .3 315 .3 998 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 APPENDIX R REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHT GAINS OF PI FEMALE RATS DURING LACTATION 999 "Company SanHbed. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHT GAINS OF Pi FEMALE RATS DURING LACTATION EXPLANATORY NOTES Footnotes a No litter was delivered; therefore, no lactation data were collected. b Weighing error. Data excluded from statistical analysis. c Animal was found dead on lactation day 13. All pups were cannibalized before lactation day 7. Animal was excluded from statistical analysis. Abbreviations -- = No Data 1000 , Does not contasn TSCA CB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF PI FEMALE RATS DURING LACTATION GROUP: II-O DOSE: 0 MG/KG/DAY LACTATION DAYS: / ANIMAL NUMBER 641345 641236 641337 641328 641310 641324 641371 641332 6413583 6413893 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 0-7 -3 .1 4 .6 32 .1 -2 .9 14 .8 21 .4 13 .0 19 .4 1.3 0.8 6.5 -8.5 6.8 -0.1 -1.0 3.9 12.6 1.6 7-14 14-21 0-21 23 .5 11 .3 -0 .7 13 .7 51 .8 12 .9 -9 .5 17 .5 0 .7 16 .4 42 .0 21 .3 6 .4 21 .2 39 .7 3 .1 25 .6 12 .4 -22 .3 -18 .4 -7 .2 -6 .5 -33 .7 -14 .1 -10 .1 -26 .6 1 .5 -12 .5 -31 .0 -10 .8 -11 .1 -16 .5 -31 .4 -7 .7 -5 .7 -9 .9 -1 .9 -2 .5 -40 .0 4 .3 3 .3 20 .2 -32 .6 -28 .5 3 .5 4 .7 17 .5 2 .0 2 .1 4 .6 7 .3 -0 .7 32 .5 4 .1 1001 'Company Sanitized. Does net cou:;.aii H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi FEMALE RATS DURING LACTATION GROUP: IV-0 DOSE: 50 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER ' 641378 641263 641297 641304 641274^ 641351 641272 641258 6412762 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 0-7 7-14 14-21 0-21 3.1 6.7 10.9 44.4 -4.3 20.0 14.3 -7.0 18.9 --b 29.7 22.6 -0.5 -7.4 10.9 -5.3 22.7 17.6 27 .2 17 .2 15 .9 13 .7 25 .6 -3 .5 37 .6 28 .7 13 .8 15 .5 17 .4 20 .0 4 .8 19 .1 43 .2 16 .0 -15 .4 20 .9 -30.4 -22.6 -31.0 -15.8 -9.2 -20.9 -15.8 -21.3 -2.5 -9.9 -19.7 -8.0 -19.4 0.0 -14.1 -1.8 -7.4 -11.2 -0.1 1.3 -26.0 -46.5 12.1 -4.4 36.1 0.4 30.2 ---> -32.0 -10.6 -15.1 11.7 18.2 8.9 -45.5 -7.9 1002 Company Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi FEMALE RATS DURING LACTATION GROUP: VI-0 DOSE: 250 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 641271 6412803 6412523 6413863 641277 641233 641238 641235 641392C 641360 6413813 6413333 641239 6412283 641334 641347 6413673 641303 641339 641316 0-7 7-14 14-21 0-21 19.4 --- 15--.0- -9 .3 15 .3 0 .6 13 .3 23 .1 1.3 20--.9- 13.4 --- 5.3 27.9 17.0 7.1 ---1-.9- 23.0 24.5 20.6 - 15.5 8.6 --21.6 11.4 4--.6- 7.7 -6.9 -12.4 --- ---- -24.3 -17.9 -18.6 -3.5 - -11.6 9.8 --- -19.5 -24.6 --- -7.6 -21.5 12.6 14.1 --- --- -37 .4 -4 .2 -9 .4 17 .7 2 - 7 - . - 0 19.7 23--.0- 0.2 --- 2.3 14.1 22.7 1003 CompanySanitized. Does not contain TS" H-24616: Subchronic Toxicity jW-Day Gavage Study in Ratsjvifh One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 6412423 641284 641230 641273^ 641296 641248 641370 641243 641329 0-7 12.0 3.0 2.7 14.1 10.6 -5.6 39.6 10.5 12.0 0.0 4.3 0.0 -6.9 16.4 11.2 12.2 -9.2 30.1 7-14 14-21 0-21 26 .6 -3 .2 12 .6 20 .5 22 .2 50 .7 50 .6 24 .0 15 .6 14 .4 27 .4 27 .1 7 .2 4 .6 1 .7 21 .3 9 .2 7 .5 -17 .2 6 .9 -12 .8 -21 .0 -17 .4 -33 .1 -16 .3 -16 .6 -30 .1 -14 .7 -19 .7 -28 .4 -2 .3 -15 .8 -36 .6 -29 .1 11 .3 -14 .9 21 .4 6 .7 2 .5 13 .6 -5 .8 12 .0 -5 .3 17 .9 -26 .5 -0 .3 12 .0 -1 .3 -2 .0 5 .2 -46 .1 4 .4 11 .3 22 .7 1004 'Company Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX S REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL DAILY FOOD CONSUMPTION BY Pi FEMALE RATS DURING GESTATION 1005 (BoBSpanySanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL DAILY FOOD CONSUMPTION BY Pi FEMALE RATS DURING GESTATION EXPLANATORY NOTES Footnotes a No litter was delivered; data were excluded from statistical analysis. b No gestation data were collected since no plug was observed; however, a litter was delivered. c No gestation data were collected since no plug was observed; no litter was delivered. d Weighing error; data were excluded from statistical analysis. Abbreviations -- = No data 1006 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL DAILY POOD CONSUMPTION (grams) BY Pi FEMALE RATS DURING GESTATION GROUP: II-0 DOSE: 0 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 641345 641236 641337 641328 641310 641324 641371 641332 6413583 6413893 641317^ 641255 641403 641388 641261 641306 641349-b 641346 641308 641289 0-7 7-14 0-14 23.0 26.1 25.6 24.5 23.0 23.3 24.0 30.1 19.7 21.1 24.2 24.7 25.7 22.9 24.8 27.5 25.3 24.0 22.7 29.6 29.9 29.5 24.3 27.2 27.1 33.2 20.3 20.1 25.7 29.8 27.9 25.4 25.0 27.9 26.9 26.4 22.9 27.8 27.8 27.0 23.7 25.3 25.6 31.7 20.0 20.6 24.9 27.3 26.8 24.1 24.9 27.7 26.1 25.2 1007 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL DAILY FOOD CONSUMPTION (grams) BY Pi FEMALE RATS DURING GESTATION GROUP: IV-0 DOSE: 50 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 641378 641263 641297 641304 6412743 641351 641272 641258 6412763 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 0-7 7-14 0-14 28.2 23.9 24.1 26.6 27.2 20.1 25.7 24.8 26.4 19.7 22.0 26.5 24.9 22.3 26.4 22.0 31.1 24.0 31.1 27.0 30.1 26.6 28.2 26.1 24.0 22.0 26.4 29.6 28.7 24.0 22.4 25.8 28.8 24.5 28.1 22.4 33.7 23.6 33.5 28.1 29.2 25.2 26.1 26.4 25.6 21.1 26.0 27.2 27.6 21.9 22.2 26.1 26.8 23.4 27.3 22.2 32.4 23.8 32.3 27.6 1008 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL DAILY FOOD CONSUMPTION (grams) BY Pi FEMALE RATS DURING GESTATION GROUP: VI-0 DOSE: 250 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 641271 6412803 6412523 641386^ 641277 641233 641238 641235 641392 641360 6413813 641333C 641239 6412283 641334 641347 6413673 641303 641339 641316 0-7 7-14 0-14 21.1 24.3 23.9 21.0 24.9 25.5 22.0 21.0 23.4 20.4 27.0 2-4-.7- 23.7 23.0 27.7 20.2 24.1 26.3 25.2 23.2 26.3 22.8 23.8 29.1 29.4 26.8 21.3 25.4 20.9 25.7 --26.8 29.4 ---d 29.6 31.0 24.2 28.1 25.9 22.2 25.3 23.4 22.4 27.0 27.4 24.4 21.1 24.4 20.6 26.4 --- 25.8 26.6 ----d 28.7 25.6 24.2 27.2 25.6 1009 n^og ,,,,,{! ^nwr, re^A <- H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL DAILY FOOD CONSUMPTION (grams) BY Pi FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 6412423 641284 641230 641273s 641296 641248 641370 641243 641329 0-7 7-14 0-14 21.0 25.8 20.3 18.4 22.6 25.0 23.1 20.7 24.9 27.6 24.9 20.6 23.9 20.3 24.7 21.2 27.4 28.0 23.6 21.7 25.3 28.4 20.3 22.2 25.7 25.6 24.3 19.2 26.0 29.2 25.8 22.9 24.8 22.8 25.5 22.0 31.0 25.6 27.2 23.5 23.2 27.1 20.3 20.3 24.1 25.3 23.7 20.0 25.5 28.4 25.4 21.7 24.4 21.5 25.1 21.6 29.2 26.8 25.4 22.6 1010 ompany SamTOreA Does not eonteSn TSCA CBI H-24616: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 APPENDIX T REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL CLINICAL OBSERVATIONS IN Pi MALE RATS 1011 Company Sanitized. Does nn ^^?- H-24616: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN PI MALE RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 641114 641217 641204 641158 641100 641060 641188 641106 641175 641079 641125 641186 641052 641140 641135 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 ALOPECIA LEFT LEG(S) SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 108 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 108 SORE TAIL SACRIFICED BY DESIGN TEST DAY 108 ALOPECIA RIGHT PROMT PAW(S) ALOPECIA RIGHT FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 109 ALOPECIA RIGHT FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 100 107 100 108 78 108 100 108 85 108 107 108 78 109 109 109 1012 s&St ampany SanBSzed. Does net contain TSC" ^ . fcrtiteBl iT.tit fnntiaiw Tier* A H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN PI MALE RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 641174 641107 641072 641053 641168 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 1013 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi MALE RATS GROUP: III-O DOSE: 50 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 641087 641108 641118 641128 641091 641199 641209 641163 641129 641138 641103 641181 641171 641111 641062 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 107 LUNG NOISE SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 ' NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 WO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 78 107 85 85 78 109 1014 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN PI MALE RATS GROUP: III-O DOSE: 50 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 641156 641173 641121 641074 641191 ALOPECIA RIGHT FRONT LEG(S) ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 78 78 85 110 1015 Company Sanitized. Does no? contain TCCA C3? H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN PI MALE RATS GROUP: V-0 DOSE: 250 MG/KG/DAY AMIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 641170 641065 641126 641058 641131 641176 641119 641075 6411.80 641117 641124 641082 641151 641195 641122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 78 100 1016 & Does not contain TSCA CBt H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN PI MALE RATS GROUP: V-0 DOSE: 250 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 641184 641142 641120 641179 641164 ALOPECIA LEFT FRONT LEG(S) SORE LEFT FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 107 110 110 110 1017 Company SanKbed, Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi MALE RATS GROUP: VII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 641110 641096 641212 641068 641093 641054 641208 641193 641207 641139 641080 641078 641177 641112 641210 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 108 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 ALOPECIA LEFT FRONT PAW(S) ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 78 108 78 108 78 78 85 109 1018 IBosnpanySanRfeed. Does nnf e<waw vra ^e^ H-24616: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN PI MALE RATS GROUP: VII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 641152 641182 641150 641211 641145 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 110 85 110 1019 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 APPENDIX U REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING GESTATION 1020 H-24616: Subchronic Toxicity 90-Day Gavage Stady in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING GESTATION EXPLANATORY NOTES Notes This appendix includes only signs from rats that delivered a litter. 1021 Company Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING GESTATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 641345 641236 641337 641328 641310 641324 641371 641332 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA BOTH FRONT LEG(S) NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA ABDOMEN NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 21 21 21 1022 3. Does not contain TSCA i H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN PI FEMALE RATS DURING GESTATION GROUP: IV-0 DOSE: 50 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 641378 641263 641297 641304 641351 641272 641258 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 ALOPECIA RIGHT SIDE(S) ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) NO ABNORMALITIES DETECTED ALOPECIA LEFT FRONT LEG(S) NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA BOTH FRONT LEG(S) ALOPECIA BOTH HIND QUARTERS ALOPECIA BASE TAIL ALOPECIA ABDOMEN NO ABNORMALITIES DETECTED ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) NO ABNORMALITIES DETECTED 7 21 0 14 14 14 0 21 7 21 21 21 0 21 0 21 0 21 21 21 7 21 14 21 1023 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING GESTATION GROUP: VI-0 DOSE: 250 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 641271 641277 641233 641238 641235 641392 641360 641239 641334 641347 641303 641339 641316 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA BOTH FRONT LEG(S) ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED . NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA BOTH FRONT PAW(S) ,, 0 21 0 21 7 21 14 21 0 21 0 21 7 21 1024 Company Sanitized. Does not contain TSCA CBt H-24616: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 641284 641230 641296 641248 641370 641243 641329 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA BOTH FRONT LEG(S) ALOPECIA BOTH FRONT PAW(S) NO ABNORMALITIES DETECTED ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES' DETECTED ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA BOTH FRONT PAW(S) ALOPECIA LEFT FRONT LEG(S) 7 21 14 21 0 21 21 21 7 21 21 21 7 21 14 21 1025 'Company Sanitized. Da@s not contain TSCA CB8 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 APPENDIX V REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION 1026 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION EXPLANATORY NOTES Note This appendix includes signs from lactating rats only. 1027 3. Does not contain H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 641345 641236 641337 641328 641310 641324 641371 641332 641317 641255 641403 641388 641261 641306 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 114 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 116 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 115 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 114 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 116 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 114 ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 117 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 115 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 116 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 117 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 117 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 114 0 21 1028 eompany Sanitized. Does no! contain TSCA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN PI FEMALE RATS DURING LACTATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 641349 641346 641308 641289 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 114 ALOPECIA ABDOMEN ALOPECIA LEFT FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 115 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 116 0 21 14 21 1029 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION GROUP: IV-0 DOSE: 50 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 641378 641263 641297 641304 641351 641272 641258 641350 641376 641315 641286 641231 641338 ALOPECIA RIGHT SIDE(S) SACRIFICED BY DESIGN TEST DAY 114 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 114 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 115 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 115 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 114 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 115 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 126 ALOPECIA LEFT FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES' DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 117 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 115 14 21 21 0 21 0 21 21 1030 Company Sanitized. Does not corstein TSCA CB, H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION GROUP: IV-0 DOSE: 50 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 641373 641365 641348 641323 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 117 ALOPECIA BOTH FRONT LEG(S) ALOPECIA BOTH HIND QUARTERS ALOPECIA BASE TAIL ALOPECIA ABDOMEN SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 115 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 114 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 0 21 0 21 0 21 0 21 21 21 1031 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN PI FEMALE RATS DURING LACTATION GROUP: VI-0 DOSE: 250 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 641271 641277 641233 641238 641235 641392 641360 641239 641334 641347 641303 641339 641316 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 114 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 ALOPECIA BOTH FRONT LEG(S) ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 114 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 114 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 114 FOUND DEAD TEST DAY 107 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST' DAY 117 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 116 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 124 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 116 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 115 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 114 21 21 21 21 13 13 21 21 21 1032 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 641284 641230 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 117 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 115 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 116 ALOPECIA BOTH FRONT LEG(S) ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 115 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 114 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 114 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 115 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 116 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 115 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 114 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 117 21 21 21 21 14 21 1033 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY AMIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 641296 641248 641370 641243 641329 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 114 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 114 ALOPECIA LEFT FRONT LEG(S) MASS 1 3.5 cm RIGHT SIDE(S) MASS 2 2.0 cm LEFT SIDE(S) SACRIFICED BY DESIGN TEST DAY 117 0 21 0 21 0 21 0 21 14 14 14 14 1034 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 APPENDIX W REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION IN Pi FEMALE RATS 1035 CosMpansfSaailteed. Does not contain' H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS DuPont-4739 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION IN Pi FEMALE RATS EXPLANATORY NOTES Footnotes: a No evidence of copulation was found, but animal was pregnant. Data were excluded from statistical analysis since the animal was pregnant during part of the estrous cycle evaluation. b No precoital interval could be calculated since no evidence of copulation was found. c Mean cycle length was not calculable due to insufficient data. Abbreviations: = No Data 1036 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION GROUP II-O: 0 MG/KG/DAY ANIMAL NUMBER NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OP DAYS IN PROESTRUS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (days) 641389 22 641358 22 641332 25 641371 22 641324 23 641310 21 641328 23 641337 23 641236 26 641345 23 641289 25 641308 26 641346 23 6413498 35 641306 22 641261 25 641388 26 641403 24 641255 26 6413173 35 5% 23% 24% 23% 22% 24% 13% 4% 23% 22% 8% 31% 13% 14% 18% 24% 12% 25% 31% 9% 82% 64% 64% 77% 65% 71% 74% 74% 58% 61% 76% 65% 74% 80% 59% 72% 88% 50% 62% 74% 14% 4.50 1 14% 4.00 1 12% 4.00 4 0% 4.00 1 13% 5.00 2 5% 4.00 1 13% 5.33 2 22% 4.67 3 19% 4.75 5 17% 4.50 2 16% 6.67 4 4% 4.20 5 13% 4.00 2 6% 4.50 -jb 23% 5.00 1 4% 4.00 4 0% 10.50 5 25% 4.00 3 8% 4.75 5 17% 4.00 --jb 1037 Does not eonSain TSCA CBJ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION GROUP IV-0: 50 MG/KG/DAY ANIMAL NUMBER NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (days) 641350 25 641276 24 641258 34 641272 22 641351 22 641274 29 641304 22 641297 23 641263 23 641378 21 641323 22 641348 22 641365 23 641373 26 641318 25 641338 23 641231 25 641286 26 641315 28 641376 25 12% 25% 9% 18% 18% 24% 32% 26% 13% 10% 23% 18% 22% 23% 40% 22% 28% 19% 32% 28% 76% 67% 76% 68% 68% 69% 50% 74% 87% 71% 77% 68% 61% 65% 48% 61% 52% 65% 64% 64% 12% 5.00 5 8% 4.75 4 15% 5.40 13 14% 5.00 2 14% 4.00 2 7% 6.67 8 18% 4.00 1 0% 4.00 2 0% 2 --c 19% 1 --c 0% 4.00 1 14% 5.00 1 17% 4.00 2 12% 4.75 5 12% 5.25 4 17-% 5.00 2 20% 4.20 4 15% 5.00 5 4% 4.20 7 8% 5.67 5 1038 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL ESTROUS CYCLE PARArIETERS DURII'IG PREMATING AMD 0 3HABITATIO]N GROUP VI-0: 25C1 MG/KG/DAY ANIMAL NUMBER NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (days) 641360 24 641392 23 641235 23 641238 22 641233 22 641277 22 641386 22 641252 22 641280 22 641271 22 641316 22 641339 23 641303 24 641367 27 641347 25 641334 31 641228 25 641239 24 641333 33 641381 23 21% 26% 22% 32% 23% 18% 27% 23% 27% 14% 23% 26% 21% 19% 28% 35% 4% 13% 15% 26% 54% 61% 52% 50% 68% 73% 68% 64% 55% 68% 68% 70% 54% 70% 48% 61% 68% 75% 79% 61% 25% 4.00 4 13% 4.00 2 26% 4.00 2 18% 4.50 1 9% 4.00 1 9% 4.67 1 5% 4.00 1 14% 4.00 1 18% 4.00 1 18% 5.00 1 9% 4.00 1 4% 4.00 2 25% 4.00 3 11% 4.60 6 24% 4.00 4 3% 5.00 10 28% 7.00 4 13% 6.33 3 6% 4.00 --h 13% 5.67 2 1039 Company Sanitized. Does not contain TSCA CBt H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AMD COHABITATION GROUP VIII-0: 1000 MG/KG/DAY ANIMAL NUMBER NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTROS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (days) 641343 641368 641307 641401 641353 641320 641246 641402 641393 641265 641329 641243 641370 641248 641296 641273 641230 641284 641242 641254 24 13% 75% 13% 5.00 3 23 26% 70% 4% 4.25 2 22 23% 77% 0% 4.25 1 22 27% 64% 9% 4.00 1 22 23% 55% 23% 4.00 1 26 12% 77% 12% 5.67 5 22 27% 50% 23% 3.67 2 22 23% 73% 5% --c 3 23 22% 74% 4% 4.00 2 25 24% 64% 12% 4.00 4 25 24% 72% 4% 4.00 4 22 41% 45% 14% 5.67 1 26 15% 77% 8% 5.00 5 26 27% 54% 19% 5.00 5 21 5% 76% 19% 5.00 1 22 36% 55% 9% 5.33 1 24 29% 50% 21% 4.75 4 22 36% 64% 0% 4.67 1 27 33% 67% 0% 4.60 6 23 22% 52% 26% 4.00 2 1040 1. Does not contain TSCA CBi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 APPENDIX X REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION IN Pi FEMALE RATS 1041 Iggaapany Sanitized. Does not e9*rta?n TS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION IN Pi FEMALE RATS EXPLANATORY NOTES Notes: Refer to footnotes located in Individual Animal Estrous Cycle Parameters During Premating and Cohabitation appendix for individual animal variation. Test Days 50-70 = Test Days 71-85 = Premating Cohabitation period Abbreviations: D ^ Diestrus E = Estrus P = Proestrus X = No sample or stage could not be defined from sample. 1042 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations GROUP II-O: INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING CREMATING AND COHABITATION 0 MG/KG/DAY 1043 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations GROUP IV-0: INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION 50 MG/KG/DAY 1044 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations GROUP VI-0: INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AMD COHABITATION 250 MG/KG/DAY 1045 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations GROUP VIII-0: INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION 1000 MG/KG/DAY 1046 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 APPENDIX Y REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL ANIMAL SPERM MOTILITY DATA IN Pi MALE RATS 1047 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL ANIMAL SPERM MOTILITY DATA IN Pi MALE RATS EXPLANATORY NOTES Footnotes: a No sperm. Data excluded from calculations. 1048 H-24616: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL ANIMAL SPERM MOTILITY DATA IN PI MALE RATS GROUP 1-0 0 MG/KG/DAY Animal Number 641114 641217 641204 641158 641100 641060 641188 641106 641175 641079 Percent Motile 90 97 93 95 96 86 91 92 94 95 GROUP III-0 50 MG/KG/DAY Animal Number 641087 641108 641118 641128 641091 641199 641209 641163 641129 641138 Percent Motile 96 89 87 94 96 90 95 95 92 95 GROUP V-0 250 MG/KG/DAY Animal Number 641170 641065 641126 641058 641131 641176 641119 641075 641180 641117 Percent Motile 92 91 90 93 92 95 91 95 94 91 GROUP VI1-0 1000 MG/KG/DAY Animal Number 641110 641096 641212 641068 641093^ 641054 641208 641193 641207 641139 Percent Motile 95 91 93 92 75 97 92 85 91 1049 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations___________DuPont-4739 APPENDIX Z REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN Pi MALE RATS 1050 Compans?Sanlghed. Does no6 eoiitair H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS DuPont-4739 INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN Pi MALE RATS Footnotes: EXPLANATORY NOTES / a No sperm. Data excluded from calculations. 1051 tempanySaniateed. Does not contai-i TSCA CD) H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN PI MALE RATS GROUP 1-0: 0 MG/KG/DAY Animal Number 641114 641217 641204 641158 641100 641060 641188 641106 641175 641079 Total Normal 199 196 200 194 198 198 196 196 199 195 Tail Abnormal 0 2 0 3 0 1 2 1 1 1 Head Abnormal 1 2 0 3 2 1 2 3 0 4 Tail & Head Abnormal 0 0 0 0 0 0 0 0 0 0 Perciant Nornial 99. 5 98. 0 100 .0 97. 0 99. 0 99. 0 98. 0 98. 0 99. 5 97. 5 0: 50 MG/KG/DAY Animal Number 641087 641108 641118 641128 641091 641199 641209 641163 641129 641138 Total Normal 195 199 193 194 199 194 195 196 198 198 Tail Abnormal 1 0 0 4 1 0 1 1 2 1 Head Abnormal 4 1 7 2 0 6 4 3 0 1 Tail & Head Abnormal 0 0 0 0 0 0 0 0 0 0 Percent Normal 97. 5 99. 5 96. 5 97. 0 99. 5 97. 0 97. 5 98. 0 99. 0 99. 0 1052 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN Pi MALE RATS GROUP V-0: 250 MG/KG/DAY Animal Number 641170 641065 641126 641058 641131 641176 641119 641075 641180 641117 Total Normal 199 199 196 199 197 195 190 194 194 195 Tail Abnormal 1 1 4 0 2 2 2 3 2 3 Head Abnormal 0 0 0 1 1 3 8 3 4 2 Tail & Head Abnormal 0 0 0 0 0 0 0 0 0 0 Percent Normal 99.5 99.5 98.0 99.5 98.5 97.5 95.0 97.0 97.0 97.5 0: 1000 MG/KG/DAY Animal Number 641110 641096 641212 641068 6410933 641054 641208 641193 641207 641139 Total Normal 196 196 198 198 - 195 190 198 195 192 Tail Abnormal 1 1 0 1 1 3 1 3 2 Head Abnormal 4 3 2 1 - 4 7 1 2 6 Tail & Head Abnormal 0 0 0 0 0 0 0 0 0 Percent Normal 98.0 98.0 99.0 99.0 - 97.5 95.0 99.0 97.5 96.0 1053 onspsny Sanitized. Does not contain TSCA CB? H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 APPENDIX AA REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS IN P, MALE RATS 1054 Company SanMsred. Does not contain TSCA C6'( H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS (Millions) IN Pi MALE RATS GROUP 1-0: 0 MG/KG/DAY Animal Number Epididymal Sperm Per cauda Per g cauda 641114 641217 641204 641158 641100 641060 641188 641106 641175 641079 298.1 266.6 302.8 347.2 355.4 301.6 298.1 319.2 322.7 327.3 1226.2 822.1 1252.7 1298.4 1271.5 1040.0 1163.1 812.3 1195.4 1016.2 GROUP III-O-0: 50 MG/KG/DAY Animal Number Epididymal Sperm Per cauda Per g cauda 641087 641108 641118 641128 641091 641199 641209 641163 641129 641138 288.8 370.6 306.3 308.6 334.4 313.3 370.6 336.7 281.7 333.2 1263.7 1468.8 1198.3 1113.7 1263.1 1164.2 1136.0 1190.9 1079.0 950.0 Testicular Spermatids Per testis Per g testis 140.9 119.3 123.4 109.3 147.3 190.6 178.3 190.6 157.8 144.4 93.8 77.2 85.9 77.5 89.5 103.9 107.6 102.9 101.2 98.5 Testicular Spermatids Per testis Per g testis 118.1 137.4 140.3 146.1 151.4 151.4 170.1 157.3 177.7 175.4 79.8 105.5 96.4 80.8 101.7 105.2 112.2 102.9 105.7 102.2 1055 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS (Millions) IN PI MALE RATS GROUP V-0: 250 MG/KG/DAY Animal Number Epididymal Sperm Per cauda Per g cauda 641170 641065 641126 641058 641131 641176 641119 641075 641180 641117 370.6 316.8 286.4 286.4 320.3 242.0 353.1 322.7 376.4 339.0 1281.4 1265.2 1375.0 1218.8 1244.9 1080.8 1029.6 1046.2 1063.6 1144.2 GROUP VI I--00: 1000 MG/KG/DAY Animal Number Epididymal Sperm Per cauda Per g cauda 641110 641096 641212 641068 641093 641054 641208 641193 641207 641139 367.1 300.5 312.1 264.2 272.4 301.6 343.7 316.8 351.9 382.3 1275.9 897.6 1352.4. 1094.9 986.2 990.8 1258.9 1191.9 1052.9 1247.2 Testicular Spermatids Per testis Per g testis 169.5 142.1 138.0 119.3 125.7 100.0 180.0 208.7 172.4 203.4 114.4 101.9 101.6 90.1 82.2 56.9 102.9 128.4 101.3 113.2 Testicular Spermatids Per testis Per g testis 173.6 162.5 139.1 128.6 "107 . 6 155.5 174.2 129.2 190.6 143.8 99.4 100.2 99.1 82.7 91.2 100.8 124.0 96.6 106.2 102.8 1056 Company Sanitized. Does not conSat'n TSCA f H-24616: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproduction Evaluations___________DuPont-4739 APPENDIX BB REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION 1057 H-24616: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION EXPLANATORY NOTES Note Column labeled "Plug Observed" + indicates that a copulatory plug was observed indicates that no copulatory plug was observed Column labeled "Litter Produced" + indicates that a litter was produced indicates that no litter was produced Footnote a Because a copulatory plug was not observed, the start of gestation is unknown and, therefore, gestation length cannot be determined. Abbreviations -- = No Data 1058 H-24616: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 FEMALE ANIMALft 641345 641236 641337 641328 641310 641324 641371 641332 641358 641389 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION GROUPS: 11-0,1-0 DOSE: 0 MG/KG/DAY MALE #1 ANIMAL# 641114 641217 641204 641158 641100 641060 641188 641106 641175 641079 641125 641186 641052 641140 641135 641174 641107 641072 641053 641168 PLUG OBSERVED + + + + + + + + + + - + + + + + - + + + MALE #2 ANIMAL* PLUG OBSERVED LITTER PRODUCED + + + + + + + + - - + + + + + + + + + + GESTATION LENGTH(days) 21 22 22 22 22 23 22 22 -- ---a 22 22 21 22 22 --a 22 22 21 1059 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 FEMALE ANIMAL# 641378 641263 641297 641304 641274 641351 641272 641258 641276 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 INDIVIDUAL MATINCS DATA AND GES1'ATIOM LENGTH: Pi GENERATION GROUPS: IV-0, III-O DOSE : 50 MG/KG/DAY MALE #1 ANIMAL# 641087 641108 641118 641128 641091 641199 641209 641163 641129 641138 641103 641181 641171 641111 641062 641156 641173 641121 641074 641191 PLUG OBSERVED + , + + + + + + + + + + + + + + + + + + + MALE #2 ,, ANIMAL# PLUG . OBSERVED LITTER PRODUCED + + + + + + + - + + + + + + + + + + + GESTATION LENGTH(days) 22 21 22 23 21 22 22 22 22 22 22 22 22 22 22 22 22 21 1060 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 FEMALE ANIMAL* 641271 641280 641252 641386 641277 641233 641238 641235 641392 641360 641381 641333 641239 641228 641334 641347 641367 641303 641339 641316 INDIVIDUAL MATING DATA AND GESTATION LENGTH: PI GENERATION GROUPS: VI-0,V-0 DOSE: 250 MG/KG/DAY MALE #1 ANIMAL* 641170 641065 641126 641058 641131 641176 641119 641075 641180 641117 641124 641082 641151 641195 641122 641184 641142 641120 641179 641164 PLUG OBSERVED + + + + + + + + + + + - + + + + + + + + MALE #2 ANIMAL# PLUG OBSERVED LITTER PRODUCED + - - - + + + + + + - - + - + + - + + + GESTATION LENGTH(days) 22 --2--1 22 22 21 22 22 --22- 2-3- 23 2-2- 22 22 1061 Company Sanitized. Does noE contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 FEMALE ANIMALft 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 641242 641284 641230 641273 641296 641248 641370 641243 641329 INDIVII3UAL MAT:CNG I 3ATA AND GE;STATION LENGTH: Pi GENE]RATION GROUPS: VII 1-0, VII-0 COSE: 1000 M(3/KG/DAY MALE #1 ANIMAL# 641110 641096 641212 641068 641093 641054 641208 641193 641207 641139 641080 641078 641177 641112 641210 641152 641182 641150 641211 641145 PLUG OBSERVED + + + + + + + + + + + + + + + + + + + + MALE #2 ANIMALft PLUG OBSERVED LITTER PRODUCED + + + + + + + + + + + - + + - + + + + + GESTATION LENGTH(days) 22 22 22 22 22 22 21 22 22 22 22 2-2- 22 -2-2 22 22 22 22 1062 Company Sanitized. Does roS contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 APPENDIX CC REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY 1063 Company SaniSIzed. Does not contain TSCA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations _____DuPont-4739 REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY EXPLANATORY NOTES Footnotes a Number of pups bom exceeded the number of implantation sites counted. b No litter was delivered. c No implantation site data recorded; Animal No. 641392 died on lactation day 13. Abbreviations = No data 1064 Company Sanitized. Does not eonSain TSCA CB8 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL IMPLANTATION SITE DATA AMD IMPLANTATION EFFICIENCY GROUPS: II-O DOSE: 0 MG/KG/DAY Animal Number 641345 641236 641337 641328 641310 641324 641371 641332 641358^ 641389^ 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 Number of Implantation Sites 13 17 9 16 17 17 17 16 0 0 6 12 17 16 11 15 19 19 15 17 Implantation Efficiency 100.00 100.00 88.89 68.75 94.12 70.59 ~--_a 93.75 100.00 -__a 100.00 93.75 100.00 100.00 94.74 78.95 93.33 82.35 1065 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY GROUPS: IV-0 DOSE: 50 MG/KG/DAY Animal Number 641378 641263 641297 641304 641274^ 641351 641272 641258 641276^ 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 Number of Implantation Sites 18 13 15 12 0 15 14 16 0 16 9 18 13 16 16 16 17 14 15 15 Implantation Efficiency 94.44 100.00 86.67 50.00 100.00 92.86 100.00 100.00 77.78 100.00 -__a 93.75 81.25 93.75 94.12 92.86 100.00 93.33 1066 Company Saniaired. Does not eonaain TSCA CSi H-24616: Subchronic Toxicity 90-Day Gavage Study inJRatswith One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY GROUPS: VI-0 DOSE: 250 MG/KG/DAY Animal Number 641271 64128027 641252^ 6413861 641277 641233 641238 641235 641392C 641360 641381^ 641333A 641239 641228^ 641334 641347 641367^ 641303 641339 641316 Number of Implantation Sites 15 0 0 0 13 16 17 12 15 0 0 18 0 18 17 0 15 17 15 Implantation Efficiency 100.00 100.00 93.75 76.47 83.33 86.67 88.89 88.89 64.71 93.33 82.35 86.67 1067 Company Sanitized. Does not contain TSCA CB't H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY GROUPS: VIII-0 DOSE: 1000 MG/KG/DAY Animal Number 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 641242^ 641284 641230 641273^ 641296 641248 641370 641243 641329 Number of Implantation Sites 16 16 15 13 17 16 15 15 17 15 20 0 18 14 0 17 13 11 15 15 Implantation Efficiency 75.00 93.75 93.33 92.31 88.24 100.00 100.00 86.67 100.00 __-a 95.00 88.89 100.00 88.24 -__a 100.00 100.00 100.00 1068 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 APPENDIX DD REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL PUP SURVIVAL: Fi GENERATION 1069 'Company Sanitized. Does not contain TSCA C81 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL PUP SURVIVAL: Pi GENERATION EXPLANATORY NOTES DuPont-4739 Footnotes a No litter delivered. b Dam was found dead on lactation day 13 (test day 107). All pups were dead before day 7 of lactation. 1070 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL NUMBER 641345 641236 641337 641328 641310 641324 641371 641332 6413588 641389s 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 BORN 13 17 8 11 16 12 18 15 --- - 6 16 17 15 11 15 18 15 14 14 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY BTOMBEI^ OF PUPS BORN E'RECULLING POSTCULLIISG ALIVE DAY 4 DAY 4 DAY 7 DAY 14 13 13 17 16 8 8 11 10 14 14 12 12 18 18 15 15 - - - 6 6 - - 16 16 17 17 15 14 11 11 13 13 17 17 15 15 14 14 14 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 -- -- -- - --- -6 - 6 6 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 DAY 21 8 8 8 8 8 8 8 8 - - 6 8 8 8 8 8 8 8 8 8 1071 Cwmpiaay ranted. Does rot contain TSCA CB^ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 ANIMAL NUMBER 641345 641236 641337 641328 641310 641324 641371 641332 6413583 6413898 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 BORN 6 6 5 5 9 4 8 10 --3 - 5 9 8 3 9 8 7 8 6 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY NUMBER 0]? MALE PUP;3 BORN ,PRECXJLLING POSTCULLIIMG ALIVE DAY 4 DAY 4 DAY 7 DAY 14 6 6 4 4 4 6 6 4 4 4 5 5 5 5 5 5 5 4 4 4 9 9 4 4 4 4 4 4 4 4 8 8 4 4 4 10 10 4 4 4 - - -- --- - 3 -3 - -3 - - 3 --3 - 5 5 4 4 4 9 9 4 4 4 8 8 3 3 3 3 3 3 3 3 8 8 4 4 4 8 8 4 4 4 7 7 4 4 4 8 8 4 4 4 6 5 4 4 4 DAY 21 4 4 5 4 4 4 4 4 -- 3 4 4 3 3 4 4 4 4 4 1072 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL NUMBER 641345 641236 641337 641328 641310 641324 641371 641332 6413583 6413893 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 BORN 7 11 3 6 7 8 10 5 - - 3 11 8 7 8 6 10 8 6 8 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY NUMBER OF FEMALE PU1?S BORN P RECULLING POSTCULLIIre ALIVE DAY 4 DAY 4 DAY 7 DAY 14 7 7 4 4 4 11 10 4 4 4 3 3 3 3 3 6 5 4 4 4 5 5 4 4 4 8 8 4 4 4 10 10 4 4 4 5 5 4 4 4 -- -- - - -- --- -- 3 3 3 3 3 --11 11 4 4 4 8 8 4 4 4 7 6 5 5 5 8 8 5 5 5 5 5 4 4 4 9 9 4 4 4 8 8 4 4 4 6 6 4 4 4 8 8 4 4 4 DAY 21 4 4 3 4 4 4 4 4 -- 3 4 4 5 5 4 4 4 4 4 1073 Company Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ANIMAL NUMBER 641345 641236 641337 641328 641310 641324 641371 641332 641358s 6413893 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 INDIVIDUAL PUP SURVIVAL: FI GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY NUMBER 0 F PUPS iEX RATI 0 (MALES) 0 .46 0 .35 0 .63 0 .45 0 .56 0 .33 0 .44 0 .67 - -- 0 .50 0 .31 0 .53 0 .53 0 .27 0 .60 0 .44 0 .47 0 .57 0 .43 % BORN A LIVE ()-4 DAY VI.ABILITY 100. 0 100. 0 100. 0 100. 0 87. 5 100. 0 100. 0 100. 0 - - -- - 100. 0 100. 0 100. 0 100. 0 100. 0 86. 7 94. 4 100. 0 100. 0 100. 0 100 .0 94 .1 100 .0 90 .9 100 .0 100 .0 100 .0 100 .0 - -- 1 0 - 0 - . - 0 100 .0 100 .0 93 .3 100 .0 100 .0 100 .0 100 .0 100 .0 92 .9 DuPont-4739 LACTA'noN IND:EX 100 .0 100 .0 100 .0 100 .0 100 .0 100 .0 100 .0 100 .0 - - - - 100 .0 100 .0 100 .0 100 .0 100 .0 100 .0 100 .0 100 .0 100 .0 100 .0 1074 Company Sanitized. Does not contain TSCA CB'I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ANIMAL NUMBER 641345 641236 641337 641328 641310 641324 641371 641332 6413583 641389s 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY MOMBER OF MALE PUPS % BORM ALIVE 0-4 DAY VIABILITY LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 88.9 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 83.3 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-4739 1075 Company Sanitized. Does sot conlam TSCA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ANIMAL NUMBER 641345 641236 641337 641328 641310 641324 641371 641332 6413588 6413893 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY NUMBER OF FEMALE PUPS % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 100.0 100.0 100.0 100.0 71.4 100.0 100.0 100.0 100.0 90.9 100.0 83.3 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 83.3 90.0 100.0 100.0 100.0 100.0 100.0 100.0 85.7 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-4739 1076 Company Sanitized. Does not contain TSCA CBE H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL MOMBER 641378 641263 641297 641304 6412743 641351 641272 641258 6412763 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 BORN 17 13 13 6 - 15 13 16 --16 7 18 14 15 13 15 16 13 15 14 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: IV-0 DOSE: 50 MG/KG/DAY NUMBE3i OF PUPS BORM P RECULLING POSTCULLI11G ALIVE DAY 4 DAY 4 DAY 7 DAY 14 17 17 8 8 8 13 13 8 8 8 13 12 8 8 8 6 6 6 6 6 - - 14 14 8 8 8 13 13 8 8 8 16 16 8 8 8 16-- 15 - 8 --8 - 8 7 7 7 7 7 18 18 8 8 8 14 14 8 8 8 15 14 8 8 8 13 13 8 8 8 15 15 8 8 8 16 14 8 8 8 13 13 8 8 8 15 15 8 8 8 14 14 8 8 8 DAY 21 8 8 8 6 --8 8 8 8 7 8 8 8 8 8 8 8 8 8 1077 Company Sanitized. Does not contain TSCA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL NUMBER 641378 641263 641297 641304 641274s 641351 641272 641258 641276s 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 BORN 9 3 7 1 6 5 6 --8 - 4 9 8 5 4 7 9 10 8 6 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: IV-0 DOSE: 50 MG/KG/DAY NUMBER 01 MALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 9 9 4 4 4 3 3 3 3 3 7 6 4 4 4 1 1 1 1 1 -6 - --6 - -4 - - 4 -4 - 5 5 4 4 4 6 6 4 4 4 -8 - - 8 --4 - 4 - 4 4 4 4 4 4 9 9 4 4 4 8 8 4 4 4 5 4 4 4 4 4 4 4 4 4 7 7 4 4 4 9 8 4 4 4 10 10 5 5 5 8 8 4 4 4 6 6 4 4 4 DAY 21 4 3 4 1 -4 - 4 4 - 4 4 4 4 4 4 4 4 5 4 4 1078 Company Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL NUMBER 641378 641263 641297 641304 6412743 641351 641272 641258 6412763 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 BORN 8 10 6 5 - 9 8 10 -8 - 3 9 6 10 9 8 7 3 7 8 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: IV-0 DOSE: 50 MG/KG/DAY NUMBER OF FEMALE PU]PS BORN P RECULLING POSTCULLII1G ALIVE DAY 4 DAY 4 DAY 7 DAY 14 8 8 10 10 6 6 5 5 - 8 -8 - 8 8 10 10 --8 --7 - 3 3 9 9 6 6 10 10 9 9 8 8 7 6 3 3 7 7 8 8 4 4 4 5 5 5 4 4 4 5 5 5 - 4 - 4 4-- 4 4 4 4 4 4 -4 - --4 - --4 3 3 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 3 3 4 4 4 4 4 4 DAY 21 4 5 4 5 4-- 4 4 --4 - 3 4 4 4 4 4 4 3 4 4 1079 Company Sanitized. Does no! contain TSCA CBJ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ANIMAL NUMBER 641378 641263 641297 641304 641274s 641351 641272 641258 641276s 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: IV-0 DOSE: 50 MG/KG/DAY NUMBER OF PUPS SEX RATIO (MALES) % BORN ALIVE 0-4 DAY VIABILITY 0.53 0.23 0.54 0.17 0.40 0.38 0.38 0.50 0.57 0.50 0.57 0.33 0.31 0.47 0.56 0.77 0.53 0.43 100.0 100.0 100.0 100.0 93.3 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 92.3 100.0 100.0 100.0 100.0 93.8 100.0 100.0 100.0 93.3 100.0 100.0 87.5 100.0 100.0 100.0 DuPont-4739 LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 1080 Company Sanitized. Does not eorta'ni TSCA CSi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ANIMAL NUMBER 641378 641263 641297 641304 6412743 641351 641272 641258 6412763 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: IV-0 DOSE: 50 MG/KG/DAY NUMBER OF MALE PUPS % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 85.7 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 80.0 100.0 100.0 88.9 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-4739 1081 Company Sanitized Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ANIMAL NUMBER 641378 641263 641297 641304 641274s 641351 641272 641258 641276s 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: IV-0 DOSE: 50 MG/KG/DAY NUMBER OF FEMALE PUPS BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 100.0 100.0 100.0 100.0 88.9 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 87.5 100.0 100.0 100.0 100.0 100.0 100.0 85.7 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-4739 1082 SanffeeA Does not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL NUMBER 641271 641280a 641252s 641386a 641277 641233 641238 641235 641392-13 641360 6413813 6413333 641239 641228a 641334 641347 6413678 641303 641339 641316 BORN 15 ---- - 13 15 13 10 13 13 - 16 16 11 - 14 14 13 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: VI-0 DOSE: 250 MG/KG/DAY NQMBEI1 OF PUPS BORN P RECULLING POSTCULLIISTG ALIVE DAY 4 DAY 4 DAY 7 DAY 14 14 13 8 8 8 - 13 13 15 15 12 12 10 10 13 12 13 13 --- -- ----- --- -- 8-- 8 8 8 8 8 8 8 7 8 8 8 -- 8 0 8 8 8 -- -- -- -- --- - - - 16 16 8 8 8 1-6-- 16-- - 8 11 11 8 - - 8 8 8 8 -14-- - 13 14 14 13 13 - - - -8 - ---8 8 8 8 8 8 8 8 DAY 21 8 --- - 8 8 7 8 8 - -8 8 8 --8 8 8 1083 .Company SanBSfcred. Does not eornfaHn r fur's, wl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL NOMBER 641271 641280a 641252s 6413863 641277 641233 641238 641235 641392^ 641360 64138ia 6413333 641239 641228s 641334 641347 641367a 641303 641339 641316 BORN 6 ---- -8 - 9 5 4 8 4 ---- 12 11 7 8 6 6 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: VI-0 DOSE: 250 MG/KG/DAY NOMBER 01? MALE PUP;3 BORN P RECULLING POSTCULLII1G ALIVE DAY 4 DAY 4 DAY 7 DAY 14 6 5 4 4 4 - - -- -- - - --- - - -- - - 8 8 4 4 4 -- 9 9 4 4 4 5 5 4 4 4 4 4 4 4 4 8 4 8 4 4 4 0 4 - .4 - - - - --- - --- - 12 -12-- --4 - --4 - --4 - - -1-1 11-- - 4 - 4 4 7 7 4 4 4 8 -8 - 4 - 4 - 4 6 6 4 4 4 6 6 4 4 4 DAY 21 4 ---- - 4 4 4 4 - 4 --- - 4 --4 - 4 - 4 4 4 1084 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: VI-0 DOSE: 250 MG/KG/DAY AHIMAL NUMBER 641271 641280a 641252a 6413868 641277 641233 641238 641235 64139223 641360 6413818 641333s 641239 641228s 641334 641347 641367s 641303 641339 641316 BORN 9 - --5 - 6 8 6 5 9 -.-- 4 - 5 4 - 6 8 7 NUMBER OF FEMALE PU1PS BORN P'RECULLING POSTCULLI11G ALIVE DAY 4 DAY 4 DAY 7 8 8 - - - -- --- - 5 --5 - 6 6 7 7 6 6 5 4 9 9 -- --- --4 - - 4 -5 - - -5 - 4 4 6-- --5 - 8 8 7 7 4 4 - - - 4 4 4 4 4 4 4 4 4 0 4 4 - - - -- -4 - 4 - - 4 4 4 4 -4 - --4 4 4 4 4 DAY 14 4 --. 4-- 4 3 4 -4 --- 4 -4 - 4 -4 - 4 4 DAY 21 4 --4-4 3 4 -4 - - 4 --4 4 --4 - 4 4 1085 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ANIMAL NUMBER 641271 641280a 641252a 6413863 641277 641233 641238 641235 641392^ 641360 6413813 6413333 641239 6412283 641334 641347 6413673 641303 641339 641316 INDIVIDUAL PUP SURVIVAL: Pi GENERATION GROUP: VI-0 DOSE: 250 MG/KG/DAY NUMBER OF PUPS SEX RATIO (MALES) % BORN ALIVE 0-4 DAY VIABILITY 0.40 93.3 92.9 0.62 0.60 0.38 0.40 0.62 0.31 0.75 0.69 0.64 0.57 0.43 0.46 100.0 100.0 92.3 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 92.3 100.0 100.0 100.0 100.0 92.9 100.0 100.0 __DuPont-4739 LACTATION INDEX 100.0 100.0 100.0 87.5 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 1086 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ANIMAL NUMBER 641271 641280a 641252s 6413868 641277 641233 641238 641235 641392-fa 641360 6413813 6413333 641239 6412288 641334 641347 6413673 641303 641339 641316 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: VI-0 DOSE: 250 MG/KG/DAY NUMBER OF MALE PUPS % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 100.0 83.3 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-4739 1087 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ANIMAL NUMBER 641271 641280s 6412523 641386s 641277 641233 641238 641235 6413921 641360 641381s 641333s 641239 641228s 641334 641347 641367s 641303 641339 641316 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: VI-0 DOSE: 250 MG/KG/DAY NUMBER OF FEMALE PUPS BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 88.9 100.0 100.0 100.0 100.0 87.5 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 80.0 100.0 100.0 100.0 100.0 83.3 100.0 100.0 100.0 100.0 75.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-4739 1088 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL NUMBER 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 6412428 641284 641230 6412738 641296 641248 641370 641243 641329 BORN 12 15 14 12 15 16 15 13 17 18 19 - 16 14 --15 15 11 15 15 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY NOMBE1^ OF PUPS BORN P'RECULLING POSTCULLI1TO ALIVE DAY 4 DAY 4 DAY 7 DAY 14 12 12 8 8 8 14 14 8 8 8 14 14 6 6 6 12 12 8 8 8 15 15 8 8 8 15 15 8 8 8 15 14 8 8 8 13 13 8 8 8 17 17 8 8 8 18 18 8 8 8 19 19 8 8 8 - - - - 16 16 8 8 8 14 14 8 8 8 13 - 13 ..-8 -8 - 8 15 15 8 8 8 11 11 8 8 8 15 14 8 8 8 15 15 8 8 8 DAY 21 8 8 6 8 8 8 8 8 8 8 8 - 8 8 8 8 8 8 8 1089 Gampwy Sanitized. Does not contain TSCA CO! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL NUMBER 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 6412423 641284 641230 641273S 641296 641248 641370 641243 641329 BORN 10 8 2 5 9 9 6 10 9 9 7 - 6 4 --9 - 5 4 6 10 INDIVIDUAL PUP SURVIVAL: FI GENERATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY NUMBER 0]? MALE PUP!3 BORN P RECULLING POSTCULLIlSG ALIVE DAY 4 DAY 4 DAY 7 DAY 14 10 10 7 7 2 2 5 5 9 9 8 8 6 5 10 10 9 9 9 9 7 7 - -6 - - 6 4 4 - - 7 7 5 5 4 4 6 6 10 10 6 6 6 4 4 4 2 2 2 4 4 4 4 4 4 4 4 4 4 4 4 5 5 5 4 4 4 4 4 4 4 4 4 --4 - --4 - 4 4 4 4 --4 - 4 --4 - 4 4 4 4 4 4 4 4 4 4 4 4 DAY 21 6 4 2 4 4 4 4 5 4 4 4 --4 - 4 -4 - 4 4 4 4 1090 1. DOR? -3'1 C'..?-.^;rs "<';: H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL NUMBER 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 6412423 641284 641230 6412733 641296 641248 641370 641243 641329 BORN 2 7 12 7 6 7 9 3 8 9 12 - 10 10 6 10 7 9 5 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY NUMBER OF FEMALE PU1?S BORN P'RECULLIMG POSTCULLII1G ALIVE DAY 4 DAY 4 DAY 7 DAY 14 2 2 2 2 2 7 7 4 4 4 12 12 4 4 4 7 7 4 4 4 6 6 4 4 4 7 7 4 4 4 9 9 4 4 4 3 3 3 3 3 8 8 4 4 4 9 9 4 4 4 12 12 4 4 4 10 1-0- --4 --4 - --4 - 10 10 4 4 4 - - - - 6 6 4 4 4 10 10 4 4 4 7 7 4 4 4 9 8 4 4 4 5 5 4 4 4 DAY 21 2 4 4 4 4 4 4 3 4 4 4 --4 - 4 --4 - 4 4 4 4 1091 H-24616: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproduction Evaluations ANIMAL NUMBER 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 6412428 641284 641230 6412733 641296 641248 641370 641243 641329 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP': VIII-0 DOSE: 1000 MG/KG/DAY NUMBER OF PUPS SEX RATIO (MALES) % BORN ALIVE 0-4 DAY VIABILITY 0.83 0.53 0.14 0.42 0.60 0.56 0.40 0.77 0.53 0.50 0.37 0.38 0.29 0.60 0.33 0.36 0.40 0.67 100.0 93.3 100.0 100.0 100.0 93.8 100.0 100.0 100.0 100.0 100.0 100.0 100.0 86.7 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 93.3 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 93.3 100.0 DuPont-4739 LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 1092 Sanitized. RO contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ANIMAL NUMBER 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 6412423 641284 641230 641273s 641296 641248 641370 641243 641329 INDIVIDUAL PUP SURVIVAL: PI GENERATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY NUMBER OF MALE PUPS % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 100.0 87.5 100.0 100.0 100.0 88.9 100.0 100.0 100.0 100.0 100.0 100.0 100.0 77.8 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 83.3 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-4739 1093 . Does not con-Saw TSCA C"-'1; H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ANIMAL NUMBER 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 6412428 641284 641230 6412738 641296 641248 641370 641243 641329 INDIVIDUAL PUP SURVIVAL: PI GENERATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY NUMBER OF FEMALE PUPS % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 88.9 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-4739 1094 Company Sanitized. Does not contain TSCA OSI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 APPENDIX EE REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL PUP WEIGHTS: Fi GENERATION 1095 .Company Sanitized. Does not contain ^SCA f'Ql H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS DuPont-4739 INDIVIDUAL PUP WEIGHTS: Fi GENERATION EXPLANATORY NOTES Footnotes a No litter delivered. b No live pups on lactation day 7. c Found dead test day 107. d One pup was incorrectly designated as female. Data were excluded from calculations. 1096 Company SanStfzed. Does orrt ewfan f^ffi. c^( H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grains) : Lactation Day 0 FI Generation Group: II-O Dose: 0 mg/kg/day Animal Pup Pup Number Number Sex 1 2 3 4 5 6 7 8 9 641345 641236 641337 641328 641310 641324 641371 641332 S 6.7 7.4 7 .2 7.7 7 .1 7 .4 S 6.1 6.4 6 .9 6.2 6 .4 7 .2 6.8 S 6.8 6.8 7 .0 6.1 6 .8 6 .2 ? 6.1 5.9 6 .0 6.3 6 .1 6 .3 5.9 6.1 6.2 S 8.0 7.3 8 .1 7.8 6 .8 ? 7.6 7.2 6 .9 S 7.6 9.0 7 .7 7.5 8 .2 9 7.1 7.6 7 .7 7.9 6 .8 8 .2 S 6.7 7.1 6 .8 7.3 6 .5 6 .7 5.9 7.0 6.5 9 5.8 6.5 6 .3 6.8 6 .8 S 7.3 6.8 7 .2 7.6 $ 6.4 7.1 7 .5 5.7 7 .2 6 .6 7.2 7.0 S 7.3 6.2 7 .4 6.9 6 .5 6 .4 6.9 6.4 ? 6.4 6.2 6 .2 5.2 5 .7 6 .6 5.5 6.2 6.3 S 6.8 6.9 7 .6 7.2 6 .8 7 .6 7.4 6.6 6.9 9 7 .1 6.8 6 .9 6.9 6 .8 6413583 e 2 641389s S 2 DuPont-4739 10 11 6.8 5.4 6.2 7.2 1097 Company SanRlzed. Does notewtern fwa ^ H-24616: Subchronic Toxicity 90-DayGavage Study in Rats with One-Generation Reproduction Evaluations Animal Number 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 Inciividucil Pup Weight'-s (greUtIS) : Lactation D ay O FI Geiier,at ion Group:: II-() DC)se: () mg/kc?/d,ay Pup PI;ip Numbtsr Sex 1 2, 3 4 5 6 7 8 9 S 7.1 7.9 7.6 9 8.0 7.2 7.0 e 6.8 6.6 7.0 6.5 6.2 $ 6.0 5.4 6.0 6.4 6.3 5.9 6.4 6 .2 5.7 S 7.1 7.0 6.7 6.6 6.5 6.5 6.5 7 .5 6.3 2 6.3 6.6 6.9 6.4 6.6 5.9 6.4 6 .0 S 6.6 7.2 7.5 7.8 7.3 7.2 7.2 7 .4 S 6.7 7.1 6.5 6.8 6.6 6.6 6.6 S 7.8 7.0 7.5 2 5.6 6.9 6.8 7.7 6.8 6.7 6.5 6 .3 S 6.7 6.8 6.7 6.6 6.7 6.8 7.2 6 .3 9 6.1 6.1 6.1 6.7 6.0 S 6.7 4.4 4.8 5.5 5.5 5.7 5.2 5 .8 S 5.0 5.8 5.4 5.3 5.8 5.0 4.2 6 .0 5.2 S 6.2 5.7 6.3 6.4 6.9 6.7 6.1 9 5.5 6.0 5.6 6.1 5.8 6.5 5.9 6 .4 S 7.5 7.1 6.9 5.4 6.1 4.0 6.6 7 .5 9 6.2 6.6 7.5 6.6 6.3 6.3 S 3.5 5.9 6.0 5.6 5.9 5.8 9 5.7 5.2 5.4 5.0 5.3 5.2 5.6 5 .8 DuPont-4739 10 11 6.0 6.1 1098 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number 641378 641263 641297 641304 641274s 641351 641272 641258 641276s 641350 Individual Pup Weights (grams): FI Generation Lactation Day 0 Group: IV-0 Dose: 50 mg/kg/day Pup Pup Number ---------------- Sex 1 2 3 4 5 6 7 8 S 6 .8 7 .0 6 .4 6 .4 6 .1 7 .2 6. 5 6 .7 S 6 .3 6 .3 6 .3 6 .5 7 .4 5 .9 6. 5 6 .2 S 6 .0 5 .6 6 .0 ? 5 .2 5 .6 5 .6 5 .6 5 .4 5 .7 5. 5 5 .6 S 7 .5 7 .6 7 .9 7 .8 8 .1 7 .8 7. 1 $ 7 .2 6 .9 6 .8 7 .2 7 .3 7 .2 S 7 .9 9 7 .3 8 .0 7 .6 7 .5 6 .1 S S S 6 .0 5 .7 6 .1 6 .1 5 .7 5 .9 2 6 .0 5 .8 5 .6 5 .5 6 .1 5 .4 5. 5 5 .7 S 7 .3 7 .3 7 .1 6 .6 6 .7 9 7 .1 6 .5 6 .2 7 .2 6 .8 6 .5 6. 2 6 .3 S 7 .1 7 .5 7 .1 7 .3 6 .9 7 .6 9 7 .2 7 .2 6 .9 7 .2 6 .7 6 .5 6. 5 5 .2 S 9 S 6 .8 7 .0 6 .1 6 .6 6 .7 7 .1 6. 7 7 .3 9 6 .8 6 .5 6 .4 6 .4 6 .3 6 .5 5. 7 6 .7 DuPont-4739 9 10 6 .9 5 .8 5.8 6 .5 6.9 1099 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 Indiv;Idual 1Pup We;i-ghts (grams;>= Lactation Day 0 FI Genercition Gro'up: I V-0 Dose: 50 m .g/kg/day Pup N[umber Pup Sex 1 2 3 4 5 6 7 8 S 7.1 7.3 6.7 6.7 9 6.6 5.8 5.8 S 6.3 6.7 7.0 6.8 6.8 6.4 6.7 5.4 9 5.8 6.1 6.4 5.9 6.3 6.4 5.4 6.1 S 7.6 6.1 6.9 6.9 6.7 7.4 7.1 9 6.7 6.1 6.4 6.6 6.3 6.4 6.5 S 6.4 7.3 6.7 6.9 7.3 $ 6.1 6.9 6.4 6.1 5.9 6.9 6.3 6.2 S 6.5 6.8 6.5 7.0 9 6.2 6.4 6.0 5.7 6.2 6.8 6.1 6.2 S 6.3 6.7 6.0 6.0 6.1 6.5 6.6 9 5.8 6.0 6.3 5.9 5.5 6.0 5.9 5.7 S 7.2 6.9 7.0 7.1 6.7 7.3 6.7 6.7 9 6.8 6.5 6.5 6.8 6.6 6.7 6.7 <S 7.6 7.6 8.0 7.3 7.7 8.0 7.6 7.4 9 7.5 7.6 7.0 S 7.1 6.9 6.4 6.3 6.6 6.7 7.1 6.8 9 6.3 6.5 6.5 6.5 6.3 6.6 6.1 S 6.1 6.0 6.7 6.1 6.3 6.7 9 5.9 6.1 6.3 6.2 5.8 6.0 5.7 5.7 DuPont-4739 9 10 5.7 6.2 6.2 5.0 6.1 7.0 7.8 8.1 1100 Ssmpmy Sairiteed. Does not eonSaIn TSCA CB( H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 Animal Number 641271 641280a 6412523 641386a 641277 641233 641238 641235 641392^,0 641360 Individual Pup Weights (grams): P^ Generation Lactation Day 0 Group: VI-0 Dose: 250 mg/kg/day 7 8 9 Pup Pup Number ---------------- Sex 1 2 3 4 5 6 S 6.9 6 .6 6 .4 6.0 6 .4 6. 6 S 6.6 6 .0 6 .6 6.2 5 .9 5. 8 6.8 5.8 S $ S $ S $ S 6.7 6 .0 5 .9 6.6 6 .0 6. 4 6.0 6.6 S 5.8 6 .0 6 .2 6.1 6 .0 S 5.7 6 .3 6 .7 6.1 6 .5 6. 2 6.5 6.2 6.7 $ 5.9 5 .8 5 .8 5.8 5 .9 5. 7 S 7.5 6 .9 7 .3 7.1 7 .1 ? 7.1 6 .2 5 .4 6.2 6 .2 6. 9 6.6 S 6.2 6 .2 5 .5 6.1 ? 5.5 5 .8 5 .9 5.8 5 .8 5. 5 S 6.7 6 .7 6 .4 6.4 6 .5 5. 7 6.0 5.8 9 6.4 5 .9 6 .2 5.4 6 .4 S 7.4 6 .9 7 .5 6.3 $ 7.3 7 .2 6 .9 6.5 6 .6 7. 3 6.7 7.5 5.8 1101 'Company Sanitized. Does not eonfa'n T^CA CB? H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number 64138ia 6413333 641239 6412283 641334 641347 6413673 641303 641339 641316 Individual Pup Weights (grains) : Lactation Day 0 PI Generation Group: VI-0 Dose: 250 mg/kg/day Pup Pi:lp Muaifc>er Sex 1 2 3 4 5 6 7 8 9 ] -0 S f $ e s s 5 .8 5 .8 6 .1 6 .9 5 .9 6 .6 6 .7 6 .2 5 .8 6 .0 9 6 .2 5 .8 4 .9 5 .8 s ? s 6 .2 7 .2 6 .7 7 .3 6 .9 6 .5 7 .3 6 .4 7 .4 6 .3 ? 5 .6 7 .2 6 .1 6 .4 5 .4 s 8 .3 8 .6 7 .7 8 .4 8 .7 7 .3 8 .1 9 8 .2 7 .8 8 .6 7 .5 s s s 7 .7 6 .9 7 .2 6 .8 7 .1 7 .1 6 .8 7 .1 $ 6 .8 7 .0 6 .4 6 .6 6 .9 7 .3 s 7 .2 7 .1 6 .9 7 .0 7 .3 6 .8 ? 6 .7 6 .6 7 .0 6 .5 6 .5 6 .8 6 .7 6 .5 <? 7 .0 6 .4 6 .7 6 .6 6 .7 6 .9 s 5 .8 6 .3 6 .4 6 .7 6 .0 5 .7 6 .6 DuPont-4739 1:L 1;2 5. 4 5. 8 6. 6 1102 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 Inciividu al PU]? Weig(hts. ('grams)1 : Lac-tat;Lori Day 0 FI GenerationL Group: VIII- 0 Pup Sex 1 2 , 3 4 S 7.0 7.3 7.5 7.1 9 6.5 6.2 6.2 S 6.5 7.0 6.8 5.9 S 6.3 6.2 6.3 6.7 S 5.9 5.8 $ 5.9 6.1 6.1 5.8 S 6.3 6.6 6.7 6.2 9 6.1 5.8 6.2 6.0 S 6.2 6.5 6.7 6.3 ? 6.4 5.7 6.5 6.2 S 7.2 6.6 7.9 7.2 9 6.8 5.5 7.3 6.2 S 6.1 5.7 6.1 6.5 <S 6.5 6.2 5.8 6.0 S 6.0 7.1 5.7 7.3 $ 6.2 5.4 5.9 S 5.7 6.5 6.1 6.7 ? 6.0 5.9 6.3 6.3 S 6.8 6.7 6.6 5.8 5 6.9 6.9 6.5 6.3 Dose: 1 00(3 mg/kg/day Pup N Umbsar 5 6 7 8 9 10 7. 5 7.0 7. 4 7.4 6.0 6. 2 5.7 7. 0 6. 2 6.6 6. 1 6. 1 5.9 5. 6 5.7 6.0 6.0 6. 5 6. 3 5.7 6. 1 6. 5 7.0 6. 5 6.3 6.5 6. 0 6.0 7. 3 6.7 7. 0 6.2 5. 9 5.6 4. 2 6. 1 5.5 6. 0 5.9 5. 9 6.0 5.6 6. 4 6.9 5. 3 6.5 6.0 5.2 6. 4 6.1 5. 9 6.7 6.3 5. 9 5.7 5. 9 6.0 6. 5 7.0 6. 7 6.6 6.9 6. 5 6.8 6. 0 5.2 6.6 DuPont-4739 11 12 6.1 5.7 1103 Company Sanitized. Does not contain TSCA CBi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Inciividu.al PU]? Weisfhts ( grams)1 : Lac tatioli Day 0 FI Gene:ratior.l Gr oup: VIII-O Dose: 10013 mg/k;g/day Animal Pup Pup N umber number Sex 1 2 3 4 5 6 7 8 9 10 641254 641242a 641284 641230 641273s 641296 641248 641370 641243 641329 s 6.2 6.1 4.8 6.5 6.2 6.0 5.6 9 5.8 5.7 5.9 5.3 5.5 5.8 5.7 6.4 5.6 5.5 S $ S 7.8 7.5 7.1 6.8 8.1 7.2 9 6.7 6.6 6.4 5.6 7.4 6.9 6.9 6.7 7.6 7.0 S 6.0 6.4 6.6 6.4 9 6.2 6.2 5.5 5.4 6.0 6.2 5.5 5.9 6.0 5.6 S 9 S 5.5 6.0 6.5 6.5 6.2 6.2 6.3 9 5.1 5.3 5.8 5.9 5.3 5.7 S 7.1 8.4 7.6 7.4 7.6 9 6.7 7.1 6.6 7.0 5.8 6.3 6.0 7.0 6.3 6.2 S 6.8 7.2 7.2 9 6.5 6.6 6.7 6.7 6.3 7.0 6.3 6.3 S 6.2 6.8 7.3 5.9 6.3 6.6 9 6.1 6.0 5.9 6.5 5.6 6.4 6.1 6.5 5.8 S 5.8 6.7 6.2 6.7 6.9 6.3 6.4 6.2 5.9 6.2 9 6.5 6.4 6.7 6.6 6.5 DuPont-4739 11 12 6.4 5.3 1104 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): PI Generation Lactation Day 4 Preculling Group: II-O Dose: 0 mg/kg/day Animal Number 641345 641236 641337 641328 641310 641324 641371 641332 6413583 6413893 Pup Sex l e 12 .1 9 10 .3 s 10 .4 s 9. 5 s 12 .8 2 13 .5 S 14 .6 9 12 .9 S 10 .4 9 11 .2 S 12 .0 ? 13 .6 S 11 .5 ? 9. 6 S 10 .7 9 10 .0 S 9 S S 2 10 .8 11 .0 10 .9 9. 0 13 .2 14 .2 12 .6 13 .7 9. 8 10 .3 12 .5 12 .0 9. 0 9. 8 9. 9 9. 9 3 11 .9 11 .0 11 .1 9. 7 14 .7 14 .2 15 .1 13 .5 10 .5 10 .7 13 .0 9. 5 9. 8 10 .1 9. 4 10 .0 4 11.4 11.4 11.7 9.2 14.8 13.7 13.9 10.9 11.2 13.6 13.3 11.5 9.2 10.5 9.1 Pup Number ---------------- , 7 5l 11 .4 9. 6 6 11 .6 11 .4 10.3 11 .3 10 .1 10 .5 8. 3 10.0 13 .1 13 .3 13 .1 11 .4 11 .6 9.5 11 .2 13 .1 11 .3 8. 1 9. 5 9. 3 12 .7 9. 5 10 .5 11 .1 11.8 11.7 10.3 10.8 8 9.4 11.6 14.2 9.4 10.2 9.3 DuPont-4739 9 10 10.4 10.7 11.6 9.8 10.2 7.9 11.6 1105 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 Ind]Lvidua:L Pup 'Weight S ( greims) : FI Ge:ner.at ion Lacta tion D'ay 4 I 'recul;Ling (Sroup: II-O DC>se: () ing/kig/d,ay Pup Pu1p Number Sex 1 2 3 4 5 6 7 8 9 S 15.0 14.6 12.7 9 13.5 14.3 14.1 S 9.9 10.4 10.4 10.7 10 .7 S 9.9 9.4 9.5 8.8 8. 8 8.5 9.8 8. 6 10.1 S 11.1 11.0 11.6 11.4 11 .4 11.1 11.2 11 .6 10.8 9 9.7 11.4 11.4 11.0 10 .3 12.0 11.2 10 .8 S 11.1 12.4 11.6 12.9 12 .4 12.2 12.1 12 .0 9 11.3 11.4 11.4 11.2 11 .0 11.5 <? 12.5 12.6 11.8 9 10.0 11.0 11.9 11.2 11 .8 10.6 12.6 11 .0 S 10.1 11.5 10.8 11.4 10 .9 10.9 9.7 9. 8 9 9.5 11.0 9.6 9.4 10 .3 S 11.9 8.3 10.2 9.3 10 .8 10.5 9.6 10 .7 9 9.1 11.0 8.6 9.2 10 .4 9.9 9.6 10 .5 S 12.6 11.6 12.7 10.3 11 .7 11.5 11.7 9 11.9 10.5 10.6 11.0 11 .5 11.3 11.1 11 .8 S 11.5 11.5 10.8 12.3 10 .0 11.0 7.5 12 .1 9 11.2 10.8 12.2 12.6 10 .7 10.5 S 9.2 10.1 8.2 10.2 9. 5 9 9.2 8.8 8.1 7.5 8. 1 9.6 9.1 8. 6 DuPont-4739 10 11 8.6 8.4 1106 SanilSased. Does not seomsiatn TSCA CBI H-24616: Subchronic Toxicity jW-DayGavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): FI Generation Lactation Day 4 Preculling GROUP: IV-0 DOSE: 50 MG/KG/DAY DuPont-4739 Animal Number 641378 641263 641297 641304 6412743 641351 641272 641258 6412763 641350 Pup Sex S 9 S 9 S ? S $ S $ S 9 S 9 S 9 S S S 9 1 9. 9 10 .5 9. 6 9. 6 11 .7 11 .2 16 .6 16 .0 9. 4 8. 6 11 .5 12 .6 11 .0 11 .4 12 .0 9. 0 2 '10 .3 10 .5 10 .0 10 .0 12 .6 11 .6 15 .5 9. 8 10 .0 12 .6 11 .2 10 .8 11 .5 10 .0 10 .6 3 10 .5 9. 9 10 .0 9. 5 13 .1 12 .4 15 .5 9. 0 9. 4 11 .4 11 .3 11 .5 8. 5 11 .3 11 .1 4 10 .4 10 .1 9. 1 12 .5 12 .3 12 .7 8. 8 9. 9 12 .2 12 .0 11 .6 12 .0 12 .2 10 .6 PuP N-umbesr 5 6 10 .9 10 .9 11 .6 9. 3 9. 3 12 .4 12 .2 9. 8 13 .0 11 .2 15 .2 10 .2 9. 5 12 .4 11 .4 9. 8 11 .0 9. 2 9. 2 11 .2 11 .6 10 .9 11 .6 10 .9 10 .1 9. 7 7 10 .5 8. 0 9. 2 9. 5 12 .2 11 .1 11 .6 10 .7 8 11 .5 10 .5 9. 9 9. 6 10 .2 9. 1 10 .1 9 i 9. 5 9. 0 10 .3 10 9.7 10.2 1107 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 Indiv iclual I?up WeiLghts (;grams) FI Generaitio'n Lcictatic)n Day 4 Precmil incr Grc3U;p: I V-0 Dose: 53 m g/kg/day Pup Sex 1 ^2 S 12.6 12.3 ? 12.0 10.8 S 10.4 10.6 $ 9.4 10.5 S 10.3 11.2 ? 9.6 10.5 S 12.2 11.7 S 10.9 12.0 S 12.1 11.0 9 11.2 10.3 S 10.1 9.0 S 8.8 9.0 S 9.9 10.7 2 8.1 10.0 S 11.3 12.7 ? 11.9 11.7 S 10.6 11.5 9 10.8 11.3 S 9.5 11.0 9 9.9 10.4 3 11.8 10.0 10.4 11.0 11.4 10.6 12.0 11.5 11.8 11.5 10.0 9.1 10.0 9.4 11.3 12.0 12.2 11.0 9.7 10.0 4 13.0 10.0 9.4 11.3 9.9 12.6 11.3 12.3 9.5 9.8 9.4 10.4 9.5 12.8 12.2 12.1 10.2 9.4 Pup N umbeor 5 6 9.4 10.1 10.0 10.4 12.0 12.0 9.9 11.0 10.3 10.8 12.5 12.4 12.1 9.9 10.0 8. 7 9. 4 11 .1 10 .4 11 .2 10 .7 10 .1 9. 2 11 .0 9. 9 12 .3 12 .5 11 .6 10 .7 9. 1 7 10.7 8.8 11.4 8.9 10.9 9.4 9.7 9.6 11.3 11.0 11.2 9.2 8 9. 9 9. 3 10 .1 11 .7 11 .1 9. 3 10 .3 10 .5 12 .2 10 .2 DuPont-4739 9 10 7.3 9.7 11.5 10.3 11.1 12.1 12.9 1108 Company Samlteed. Does not contain TSCA CBJ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 Animal Number 641271 641280s 641252s 641386s 641277 641233 641238 641235 641392l'c 641360 Individual Pup Weights (grams): FI Generation Lactation Day 4 Preculling Group: VI-0 Dose: 250 ing/kg/day Pup Sex l S 10 .4 ? 9. 7 s ? s ? s 2 S 11 .6 ? 11 .0 6 10 .9 ? 10 .2 S 13 .3 9 12 .3 S 10 .5 $ 10 .1 S 6. 8 ? 6. 3 S 11 .4 9 11 .4 2 1 10 .9 10 .0 11 .8 10 .9 10 .0 9. 6 13 .5 13 .0 10 .7 9. 6 6. 5 7. 2 11 .8 11 .2 3 10 .4 10 .8 12 .1 10 .5 9. 9 10 .3 12 .4 10 .8 10 .5 9. 9 6. 4 6. 4 12 .1 9. 7 1 6 7 8 9 Pup Number ---------------- 4 C 10 .3 10 .7 10 .0 9. 4 9.9 10.1 9.3 10 .4 10 .7 10 .9 9. 7 13 .5 12 .0 9. 7 9. 3 7. 1 6. 3 10 .1 11 .4 10 .1 10 .4 9. 5 9. 5 12 .9 11 .9 9. 5 6. 8 10 .9 11.2 10.1 9.4 12.4 9.6 6.9 10.9 11.1 10.8 12.2 5.9 11.9 10.4 10.2 6.6 11.8 11.1 11.4 1109 SanESized. Does not eonfa'o r^A. <?B8 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 Individual Pup Weights (grams): FI Generation Lactation Day 4 Preculling Group: VI-0 Dose: 250 mg/kg/day Animal Pup PU]p Muinbier Number Sex 1 2 3 4 5 6 ir 6 S l li0 ] .1 12 64138ia 641333a 641239 6412283 641334 641347 6413678 641303 641339 641316 S $ S 9 S 9. 6 9. 6 10 .8 9. 2 9. 1 9. 4 10 .5 9. 0 8. 9 10 .3 9 .3 9.1 ? 9. 0 9. 5 7. 5 10 .1 S 9 S 9. 9 9. 0 9. 6 8. 9 10 .6 8. 4 9. 7 10 .0 10 .7 9. 5 8 .8 S 9. 0 8. 5 10 .2 7. 5 8. 8 S 14 .1 11 .7 14 .7 13 .9 13 .0 14 .2 13 .9 9 14 .1 13 .9 13 .5 11 .8 S 9 S 12 .3 12 .0 11 .8 12 .1 12 .5 11 .4 11 .3 12 .7 S 12 .0 11 .8 11 .7 10 .8 12 .1 S 11 .9 11 .6 11 .3 11 .2 12 .1 11 .5 S 10 .8 10 .3 11 .3 11 .9 10 .3 11 .1 11 .2 11 .3 S 11 .4 11 .4 11 .7 11 .2 11 .0 10 .9 2 11 .0 11 .4 10 .5 11 .8 10 .0 10 .4 10 .6 1110 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 Individual Pup Weights (grams): F] Generation Lactation Day 4 Preculling Group: VIII-0 Dose: 1000 mg/kg/day Pup Sex 1 S 13 .6 $ 11 .6 S 9. 3 S 10 .6 S 8. 7 2 9. 8 S 10 .9 9 10 .5 S 11 .5 9 10 .0 S 10 .4 $ 11 .3 S 8. 2 S 9. 9 S 10 .8 9 10 .4 S 10 .9 9 10 .3 S 10 .7 S 9. 4 2 3 i ^ 12 .6 13 .0 9. 4 10 .6 9. 1 10 .1 10 .6 10 .1 11 .2 10 .3 10 .7 8. 6 9. 1 9. 8 11 .9 11 .0 9. 1 10 .1 12 .1 11 .4 13 .3 11 .3 11 .3 8. 9 10 .9 10 .9 10 .7 9. 3 10 .7 9. 0 9. 7 9. 0 11 .3 9. 2 10 .2 9. 0 12 .3 11 .7 4 12 .9 11 .3 10 .9 9. 3 11 .8 10 .5 10 .9 10 .0 10 .0 9. 0 10 .1 8. 9 11 .5 9. 6 9. 2 11 .5 10 .8 5 1 13 .4 10 .3 10 .3 9. 0 11 .7 10 .6 10 .1 10 .5 11 .1 10 .4 10 .2 9. 1 11 .3 7. 7 8. 3 10 .8 11 .3 Pup Number ---------------- 6 7 12 .7 13 .5 9. 3 11 .1 10 .5 11 .1 7. 3 8. 9 11 .5 10 .1 10 .6 10 .2 7. 1 10 .3 10 .0 10 .5 9. 5 10 .2 10 .3 10 .0 10 .0 10 .6 10 .3 9. 4 11 .9 10 .0 10 .0 11 .6 11 .8 ! 13 .6 8. 9 12 .1 11 .3 9. 5 10 .2 11 .3 9. 3 11 .3 11 .0 9 11.4 8.5 11.6 9.7 10.7 10.1 11.1 10.4 H 0 11 .6 8. 6 9. 6 DuPont-4739 11 12 9.2 8.7 1111 S<T,nfq8^ ve;f*a (-"ql H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number 641254 6412423 641284 641230 641273a 641296 641248 641370 641243 641329 Inciividu.al PU]? Weicfhts (.grams) : FI Gene:ratior.1 Lac<Latiori Day 4 Prec;ulling Group: VIII- 0 Dose: 10013 mg/k:g/day Pup N umber Pup Sex 1 2 3 4 5 6 7 8 9 10 S 8.7 6.8 11.1 7.6 10.3 10.4 9.8 9 8.8 10.3 10.8 8.6 9.9 9.4 9.2 8.4 9.3 7.3 S $ S 10.6 10.7 10.5 12.2 10.6 10.1 2 10.0 8.8 9.8 10.1 10.2 10.8 11.4 10.6 10.9 11.6 S 10.5 10.5 10.1 10.5 9 10.1 10.2 10.3 10.4 10.1 10.5 9.6 9.1 8.3 9.7 S 9 S 9.5 9.8 10.5 10.4 9.6 9.5 10.6 9 8.9 8.6 9.4 10.1 10.0 9.6 S 11.8 12.4 12.1 11.4 12.0 2 10.9 9.8 10.5 11.1 10.6 11.0 10.5 11.3 9.7 9.9 S 12.5 12.2 12.8 12.7 9 11.8 12.3 11.3 12.0 11.8 11.3 12.0 S 10.1 10.0 9.5 9.9 9.3 9.6 9 9.6 9.6 10.1 9.4 8.8 9.1 9.8 10.3 S 10.3 10.0 10.2 9.8 9.7 10.6 10.2 10.7 9.6 10.4 9 10.8 10.8 10.0 10.6 9.9 DuPont-4739 11 12 8.4 9.5 1112 Company Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grains) : FI Generation Lactation Day 4 Postculling GROUP: II-O DOSE: 0 MG/KG/DAY Animal Pup Number Sex l 641345 641236 641337 641328 641310 641324 641371 641332 641358s 641389s S 10 .8 9 11 .0 S 10 .9 ? 9. 0 S 12 .8 2 13 .5 S 14 .6 9 12 .9 S 9. 8 S 11 .2 S 12 .0 9 12 .0 S 11 .5 9 8.,1 S 9..5 9 10 .0 S 9 S S Pup Number ---------------- 2 -3 4 11 .9 11 .4 11 .1 9. 2 13 .2 14 .2 12 .6 13 .5 10 .9 10 .3 12 .5 12 .7 9..8 10 .5 11 .1 9..9 11 .4 11 .4 11 .7 10 .5 14 .7 14 .2 15 .1 13 .9 11 .4 11 .2 13 .0 11 .8 11 .5 10 .3 10 .8 10 .0 11 .6 10 .3 10 .1 10 .7 14 .8 13 .7 13 .1 11 .6 11 .2 13 .6 14 .2 11 .3 9. 8 10 .2 9. 1 5 13.1 DuPont-4739 1113 OampairaySanWzed. Does not eon?an rgRj'4 ^91 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individuial Puip w<siglIts (grams) FI 1Seneration Ladtati on Day 4 I'osbcul:Lingr Groupi: II -0 D ose: 0l ing,/kg/day Animal Number 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 Pup Sex 1 S 15 .0 9. 13 .5 S 9. 9 9 9. 4 S 11 .1 9 11 .0 S 12 .4 S 11 .3 S 12 .5 9 11 .0 S 11 .4 9 11 .0 <? 11 .9 9 9. 1 S 12 .6 9 10 .6 S 11 .5 9 10 .8 S 9. 2 9 8. 8 P up M-umbeir 2 3 4 14 .6 14 .3 10 .4 8. 8 11 .0 10 .3 11 .6 11 .4 12 .6 11 .2 10 .9 9. 6 8. 3 11 .0 12 .7 11 .5 10 .0 12 .6 8. 2 7. 5 12 .7 14 .1 10 .4 9. 8 11 .4 11 .2 12 .4 11 .2 11 .8 11 .8 9. 7 9. 4 10 .2 9. 2 10 .3 11 .3 11 .0 10 .7 10 .2 9. 6 10 .7 8. 6 11 .1 10 .8 12 .1 11 .5 10 .6 9. 8 10 .3 9. 3 10 .5 11 .7 11 .8 7. 5 10 .5 9. 5 9. 1 5 12.6 DuPont-4739 1114 empany Sanlteed. Does not cn"a'r> ^^rA ^ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): F]_ Generation Lactation Day 4 Postculling Group: IV-0 Dose: 50 mg/kg/day Animal Pup Number Sex 1 641378 S 9. 9 641263 9 10 .5 S 9. 6 9 10 .0 641297 641304 S 12 .6 9 11 .6 S 16 .6 2 16 .0 641274s S 9 641351 S 9. 8 9 8. 6 641272 641258 S 12 .6 9 12 .6 S 11 .0 9 8. 5 6412769 S 9 641350 S 10 .0 9 10 .6 P\lp Niunnber 2 3 4 10 .3 10 .1 10 .0 9. 3 13 .1 12 .4 11 .5 10 .9 10 .0 9. 2 12 .5 12 .3 9. 5 8. 0 9. 9 12 .4 11 .2 15 .5 15 .5 12 .7 9. 0 9. 9 11 .4 11 .3 10 .8 12 .0 10 .2 9. 5 12 .2 12 .0 11 .5 11 .1 9. 2 9. 5 12 .4 11 .4 9. 8 9. 1 11 .3 11 .1 12 .2 10 .9 11 .6 9. 7 5 9.0 15.2 DuPont-4739 1115 'Company Sanifeed. Does not contain TSCA CE H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individu al PU]p Weiglits (gr,ams) : PI Gen<sration Lact-ation Day 4 I 'osfccul:Ling Group:; IV-O DC>se: 5i0 mg/kg /day Animal Pup Number Sex 1 641376 . S 12.6 9 12.0 641315 S 10.4 ? 11.0 641286 S 10.3 S 10.5 641231 S 12.2 ? 11.3 641338 S 12.1 ? 11.5 641318 S 9.0 S 8.8 641373 S 9.9 S 10.0 641365 S 12.7 S 11.9 641348 S 10.6 9 10.8 641323 S 11.0 S 10.4 Pi-ip Numbe'r 2 3 4 12.3 10.8 10.6 10.1 11.4 10.6 11.7 11.2 11.0 9.5 10.0 9.0 10.7 9.5 11.3 11.7 12.2 11.3 9.7 10.0 11.8 10.0 9.4 9.4 11.1 9.9 12.0 8.9 11.8 12.0 9.8 9.1 10.3 10.8 12.8 12.0 12.4 11.0 9.9 9.4 13.0 8.7 9.7 11.4 10.4 12.6 11.1 12.3 11.1 9.9 9.7 11.0 9.9 10.5 11.0 12.1 10.7 9.2 5 12.1 DuPont-4739 1116 srstaSn TSCA 1 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grains): FI Generation Lactation Day 4 Postculling Group: VI-0 Dose: 250 mg/kg/day Animal Number 641271 641280a 641252s 641386^ 641277 641233 641238 641235 641392b'<:' 641360 Pup Sex S 9 S 2 S S S 9 S 2 S 9 S ? S 9 S 9 S ? 1 10 .9 9. 7 11 .6 10 .9 10 .9 9. 6 13 .5 13 .0 10 .5 10 .1 6. 8 6. 3 11 .4 11 .4 Piip Nfumber 2 3 10 .4 10 .0 10 .3 10 .8 10 .1 10 .5 9. 5 10 .3 12 .4 12 .0 10 .7 9. 3 6. 5 7. 2 11 .8 11 .2 11 .2 10 .7 10 .8 9. 7 13 .5 11 .9 10 .5 9. 5 6. 4 6. 4 12 .1 11 .4 4 10 .7 9. 3 10 .4 10 .4 10 .2 9. 4 12 .9 12 .4 9. 7 9. 6 6. 9 6. 3 10 .1 11 .4 DuPont-4739 1117 Company Sanitized. Does no! contain T8CA CB1 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): PI Generation Lactation Day 4 Postculling Group: VI-0 Dose: 250 mg/kg/day Animal Pup Number Sex l 641381a 641333s 641239 641228s 641334 641347 641367s 641303 641339 641316 S ? S 9 S 9. 6 ? 9. 0 S ? S 9. 6 2 9. 0 S 14 .7 9 14 .1 S 9 S 12 .1 $ 12 .0 S 11 .9 <S 10 .8 S 11 .4 S 11 .0 Pilp N uniber 2 1 3 9. 2 9. 1 9. 5 7. 5 10 .6 10 .2 13 .0 13 .9 8. 4 7. 5 14 .2 13 .5 12 .5 11 .8 11 .6 11 .9 11 .4 11 .8 11 .4 11 .7 11 .3 10 .3 11 .7 10 .0 4 8. 9 10 .1 9. 7 8. 8 13 .9 11 .8 11 .3 10 .8 11 .2 11 .1 11 .0 10 .4 DuPont-4739 1118 .Company SaniBlzed. Does not comWn rvr-^ cnf H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): FI Generation Lactation Day 4 Postculling Group: VIII-0 Dose: 1000 mg/kg/day Animal Number 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 Pup Sex i S 13 .6 9 11 .6 S 11 .3 ? 10 .6 S 8. 7 S 7. 3 S 10 .9 $ 10 .1 S 11 .2 9 10 .3 S 10 .7 S 8. 6 S 8. 2 2 9. 8 S 11 .9 ? 10 .4 S 9. 1 ? 10 .3 e 10 .7 9 11 .7 2 12 .9 13 .0 11 .3 10 .6 9. 1 8. 9 10 .6 10 .9 10 .7 10 .0 10 .0 9. 0 9. 1 9. 0 11 .5 11 .0 10 .2 10 .1 11 .5 11 .9 Pup Number ---------------- 3 4 13 .4 12 .7 10 .3 10 .9 10 .5 11 .1 8. 5 10 .9 10 .5 10 .9 10 .5 10 .2 9. 0 9. 7 9. 5 11 .3 9. 2 9. 6 8. 3 10 .8 11 .8 9. 2 11 .8 10 .6 12 .1 10 .6 11 .3 9. 5 10 .1 9. 7 10 .2 11 .3 9. 3 11 .6 11 .0 I 13 .5 9 .6 6 11.4 DuPont-4739 1119 Company SanRbed. Does not curtain TISCA cat H-24616: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams) : PI Generation Lactati'on Day 4 Postculling Group: VIII-0 Dose: 1000 nig/kg/day Animal Pup Number Sex 1 641254 S 6.8 S 8.6 6412423 S 2 641284 S 10.5 $ 10.0 641230 S 10.5 9 10.2 6412733 S 9 641296 641248 641370 641243 641329 S 9.5 9 8.9 S 12.4 S 9.8 S 12.5 9 12.3 S 10.1 9 9.6 S 10.6 S 10.8 Pup Ml.iitiber 2 3 7.6 10.3 9.9 9.2 12.2 10.1 10.5 10.3 10.6 10.8 10.1 10.4 10.5 9.4 12.1 10.5 12.2 11.3 10.0 10.1 10.2 10.0 10.4 10.0 11.4 11.3 12.8 11.8 9.5 9.1 9.6 10.6 4 10.4 8.4 10.1 10.6 10.5 10.1 9.6 9.6 12.0 9.7 12.7 11.3 9.3 10.3 10.4 9.9 DuPont-4739 1120 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): FI Generation Lactation Day 7 Group: II-O Dose: 0 mg/kg/day Animal Pup Number Sex 1 641345 ' S 18 .2 9 18 .2 641236 S 17 .8 2 15 .3 641337 S 20 .3 ? 19 .2 641328 S 21 .7 641310 9 20 .4 S 18 .6 641324 9 17 .8 S 22 .3 641371 2 19 .0 S 16 .3 S 18 .2 641332 S 16 .5 S 17 .2 641358s S 9 641389'3 S 9 Pup Number -- ; ! 4 [ 18 .7 16 .6 19 .4 18 .1 19 .5 20 .2 22 .0 20 .3 15 .2 18 .0 21 .5 20 .4 20 .1 15 .0 16 .4 15 .2 17 .5 18 .9 16 .3 14 .5 21 .2 20 .5 18 .8 19 .6 16 .2 16 .7 20 .4 21 .4 19 .8 17 .5 17 .7 16 .6 18 .6 17 .4 14 .2 17 .1 19 .6 20 .0 20 .4 17 .8 17 .6 21 .0 23 .3 17 .9 17 .6 17 .1 15 .5 5 20.5 DuPont-4739 1121 Company SaniHzed. Does not eontafn TSCA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individu.al Pu.p W<aigl-Its (gr<ams) L act-aticm E>ay 7 FI 1Seneration Group': II -0 Animal Number^ 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 Pup Sex 1 S 20 .8 $ 20 .1 S 16 .6 9 14 .6 S 18 .6 S 18 .8 S 20 .0 $ 18 .9 S 19 .0 ? 18 .1 S 15 .7 S? 17 .9 S 16 .5 9 16 .5 S 21 .2 9 18 .2 S 17 .5 2 14 .7 S 16 .0 S 15 .0 D(3se: 0 mg,/kg/day Pilp N1airibe;r ; 3 A1, 5 21 .5 20 .9 16 .2 13 .7 18 .5 17 .1 19 .6 18 .0 19 .6 17 .1 19 .0 14 .6 14 .2 16 .7 20 .3 20 .4 18 .6 16 .0 13 .9 15 .1 18 .9 20 .6 17 .2 15 .4 18 .3 18 .3 19 .6 18 .2 19 .0 18 .8 17 .9 15 .9 16 .5 16 .1 21 .0 20 .2 11 .5 17 .1 14 .7 14 .3 16 .7 16 .6 19 .2 18 .3 18 .8 18 .3 16 .6 17 .1 19 .7 18 .0 17 .7 19 .8 15 .0 17 .3 15 .1 12 .4 18.9 17.8 DuPont-4739 1122 H-24616: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grains) : Lactation Day 7 FI Generation Group: IV-0 Dose: 50 mg/kg/day Animal Pup Number Sex 3 641378 641263 641297 641304 641274s 641351 641272 641258 6412763 641350 S 16 .3 <? 17 .0 S 17 .1 2 16 .2 S 19 .2 9 17 .8 S 25 .5 $ 24 .8 S 9 S 15 .9 9 15 .7 S 17 .3 S 18 .7 S 19 .2 ? 14 .0 S 2 S 19 .4 2 17 .7 Pup Number r [ 3 4 16 .4 17 .1 15 .9 15 .7 18 .4 18 .1 16 .8 13 .8 16 .0 16 .3 18 .2 19 .0 18 .9 13 .6 15 .4 16 .6 19 .0 18 .7 23 .1 24 .7 20 .5 15 .0 16 .3 19 .4 19 .8 18 .4 18 .8 15 .6 13 .8 19 .5 18 .0 16 .9 20 .1 16 .8 15 .2 20 .2 17 .3 19 .2 15 .9 16 .8 17 .6 18 .6 18 .1 19 .3 15 .9 5 23.5 DuPont-4739 1123 'Company an!f?zed. Dees not corrfain TSCA CB\ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): F] Generation Lactation Day 7 Group: IV-0 Dose: 50 mg/kg/day Animal Number 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 Pup Sex S 2 S $ S S S $ S S S 9 S 9 S $ S S S 9 3 18 .8 13 .2 16 .9 16 .7 18 .4 16 .5 18 .5 14 .6 19 .6 19 .8 16 .6 12 .9 16 .0 15 .7 18 .1 18 .7 22 .1 20 .3 16 .8 15 .7 Pup Number 2 > i ^ [ 17 .1 18 .3 15 .1 17 .7 17 .1 16 .4 19 .9 18 .0 19 .4 18 .8 16 .3 13 .7 15 .8 15 .2 18 .3 17 .7 19 .1 18 .8 18 .1 17 .5 18 .6 16 .8 15 .8 16 .7 17 .3 16 .4 18 .8 18 .5 19 .7 16 .1 16 .1 16 .1 14 .8 14 .8 18 .5 18 .7 19 .2 19 .3 17 .1 15 .6 16 .0 17 .5 15 .5 16 .1 17 .5 20 .0 17 .5 18 .2 18 .8 15 .1 14 .6 16 .0 15 .3 21 .5 20 .7 18 .4 16 .6 16 .7 5 18.6 DuPont-4739 1124 'Company Sanitized. Does nn? co"?a^ Tera /lert H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): FI Generation Lactation Day 7 Group: VI-0 Dose: 250 mg/kg/day Animal Number 641271 6412803 6412523 641386a 641277 641233 641238 641235 641392fa'c 641360 Pup Sex 3 S 17 .1 9 14 .9 S 9 S 9 S 9 S 18 .6 9 17 .8 S 16 .0 9 16 .0 S 20 .7 9 18 .9 S 15 .0 9 15 .0 S 9 S 18 .1 9 18 .2 Pilp N umber 2 ) -:1 16 .0 15 .7 17 .0 16 .1 19 .5 17 .3 17 .3 17 .0 21 .3 20 .1 16 .0 14 .7 17 .6 17 .8 16 .9 14 .9 20 .7 20 .5 17 .1 14 .7 19 .1 18 .3 19 .2 18 .1 4 [ 17 .0 17 .0 17 .0 18 .1 16 .4 14 .6 19 .3 18 .9 16 .2 16 .4 17 .1 18 .0 DuPont-4739 1125 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grains) : Lactation Day 7 FI Generation Group: VI-0 Dose: 250 mg/kg/day Animal Number 641381a 6413333 641239 641228s 641334 641347 641367a 641303 641339 641316 Pup Sex S 9 S S S 9 S 9 S ? S 5 S S S ? S S S S 3 L 16 .4 16 .6 16 .2 13 .5 21 .3 18 .6 18 .5 18 .3 17 .8 16 .2 18 .9 17 .8 PU]p 2 N unibe;r ! 16. 5 16. 4 15 .9 17 .6 13. 2 14. 6 20. 0 20. 6 14 .9 12 .5 21 .2 20 .8 19. 0 18. 7 18. 1 17. 5 19. 2 19. 4 19 .6 19 .8 17 .6 18 .2 18 .8 18 .7 4 1 15 .2 13 .1 14 .9 14 .8 20 .1 21 .4 18 .1 17 .7 18 .5 15 .9 18 .5 16 .6 DuPont-4739 1126 Company Sanitized. Does not contain T8CA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Indii/idual Pup Wisights (grams) : Liactaticm Day 7 FI Generation Grou.p: V3CII-0 Dose: 1000 mg/kg/iday Animal Number 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 Pup Sex 1 S 20.7 $ 20.3 S 18.3 S 18.0 S 15.2 ? 15.5 S 18.1 2 16.5 S 19.6 ? 17.1 S 17.8 9 14.8 S 15.3 $ 13.6 S 19.2 9 17.3 S 15.8 S 14.1 (5 18.5 9 20.1 2 20.0 18.4 17.2 18.3 16.3 16.2 18.1 18.0 16.5 17.1 16.2 14.3 14.2 15.1 18.8 14.8 18.1 17.8 17.9 21.5 Pup H Umber 3 4 20.9 21.3 17.9 17.2 19.4 18.3 15.3 19.5 17.8 17.3 15.5 17.8 14.8 14.4 15.5 19.0 17.3 18.0 17.3 19.6 17.5 13.6 17.9 17.5 17.5 17.7 16.9 15.5 13.0 14.5 15.8 16.3 16.0 19.8 18.8 5 17.9 17.0 6 20.1 DuPont-4739 1127 'Company Sanifced. Does not eoRte?n TSCA CM H-24616; Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): FI Generation Lactation Day 7 Group: VIII-0 Dose: 1000 mg/kg/day Animal Number 641254 641242s 641284 641230 641273s 641296 641248 641370 641243 641329 Pup Sex S 9 S ? S ? S 9 S 9 S ? S 5 S S S S S 2 ] 13 .4 16 .5 16 .8 18 .2 17 .0 16 .3 16 .1 15 .8 18 .9 15 .9 20 .5 18 .3 16 .5 15 .0 17 .8 17 .1 Pup Number ---------------- 2 i 18. 3 15. 8 12 .7 14 .7 20. 0 17. 3 16. 4 16. 8 17 .1 15 .7 17 .0 16 .5 16. 4 15. 3 19. 1 18. 6 20. 1 20. 1 16. 9 16. 2 16. 4 17. 1 17 .9 15 .4 18 .2 16 .9 20 .2 18 .8 15 .5 16 .9 17 .3 16 .9 4 1 18 .6 12 .6 16 .9 17 .1 16 .9 16 .8 17 .2 16 .6 19 .0 15 .9 20 .3 19 .1 16 .4 17 .7 16 .7 16 .3 DuPont-4739 1128 Company Sanitized. Dees not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grains) : FI Generation Lactation Day 14 Group: II-O Dose: 0 mg/kg/day Animal Pup Number Sex ] 641345 641236 641337 641328 641310 641324 641371 641332 6413583 6413898 <? 38 .4 ? 38 .2 S 37 .9 $ 32 .3 S 38 .7 9 37 .5 S 43 .7 ? 40 .3 S 38 .2 9 36 .3 S 40 .7 ? 42 .4 S 40 .3 ? 36 .5 a 38 .5 9 36 .1 S $ S 9 Pup Number ---------------- 1 3 4 37 .4 38 .0 38 .7 35 .2 40 .0 36 .7 39 .4 40 .1 35 .9 35 .5 43 .4 42 .8 38 .7 33 .0 37 .4 35 .9 36.3 35.2 37.8 36.1 39.5 38.6 41.9 40.8 36.8 36.6 41.8 40.1 41.0 36.9 34.9 34.0 39.3 35.7 34.0 37.6 37.7 39.1 39.8 32.2 37.1 39.7 38.9 35.4 38.0 35.9 35.5 5 35.9 DuPont-4739 1129 H-24616: Subchronic Toxicity JW-DayGavage Study in Rats with One-Generation Reproduction Evaluations Individuial Pup Weigl-its (gr,ams) Lactcitio n D,ay 3.4 FI Seneration Groupi:' II -0 Animal Number 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 Pup Sex 1 S 37.3 ? 35.7 S 34.5 S 30.7 S 41.7 9 41.4 S 39.9 S 37.7 S 41.4 $ 38.8 S 38.7 9 32.8 S 39.5 9 37.7 S 36.3 9 37.1 S 28.8 9 35.7 6 33.4 ? 32.5 Diose:; 0 mg /kg/day PiJp N umbe;r i S 4 1 5 36 .3 37 .3 35 .0 30 .1 41 .9 41 .3 40 .2 38 .5 43 .1 38 .8 37 .4 38 .5 43 .0 35 .9 40 .6 38 .4 34 .7 35 .2 35 .7 33 .5 33 .6 36 .9 32 .9 34 .0 41 .5 39 .3 40 .0 38 .2 41 .6 38 .6 36 .2 35 .1 33 .8 40 .0 41 .4 38 .3 39 .2 37 .4 32 .5 35 .9 36 .5 32 .1 41 .8 40 .3 38 .2 41 .1 35 .7 35 .8 39 .1 38 .8 41 .6 39 .0 36 .9 38 .3 32 .9 32 .9 37.5 40.7 DuPont-4739 1130 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grains) : FI Generation Lactation Day 14 Group: IV-0 Dose: 50 mg/kg/day Animal Number' 641378 641263 641297 641304 641274S 641351 641272 641258 6412763 641350 Pup Sex 3 S 36 .9 S 36 .6 S 35 .5 2 35 .4 S 38 .1 9 36 .4 S 49 .2 9 46 .1 <5 S S 35 .9 ? 35 .5 S 39 .2 9 37 .2 S 40 .1 9 40 .7 S 2 S 39 .2 9 36 .8 B\jp Mimnber ) 3 4 40 .8 34 .4 36 .8 35 .3 37 .8 35 .6 37 .3 37 .0 36 .4 33 .9 37 .5 37 .6 38. 1 37. 1 34. 4 38. 2 37. 3 47 .3 47 .5 45. 9 35 .0 35 .0 40 .9 38 .6 39 .1 40 .1 33 .6 35 .9 42 .1 40 .7 36 .9 35 .5 37. 3 32. 8 40. 8 37. 8 40. 3 31. 9 40 .9 37 .1 39 .6 36 .2 36. 3 36. 9 5 35.3 42.3 DuPont-4739 1131 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individiial PU]? Weigtits (gr<ams) FI G eneration Lacteition D;ay I'1 Group : IV- 0 DCise: 513 mg/'kg/day Animal Number 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 Pup Sex 1 S 36.0 S 34.5 S 35.5 S 35.4 S 38.1 S 36.0 S 37.7 $ 37.0 e 38.9 ? 34.3 s 33.6 s 34.8 s 35.4 s 33.9 s 38.8 ? 37.1 s 38.6 s 39.2 s 36.2 s 34.9 Piip Kuiriber 2 3 4 33.8 33.4 38.7 38.5 36.0 35.6 38.3 32.3 39.9 40.0 34.7 30.8 36.2 33.7 37.6 37.0 42.3 37.6 36.1 35.6 32. 8 29. 2 40. 9 37. 6 39. 7 35. 8 38. 2 36. 9 38. 2 37. 8 33. 9 30. 7 35. 1 34. 1 38. 5 38. 9 42. 4 37. 9 36. 9 33. 7 35. 3 36. 9 40. 1 34. 7 35. 8 38. 2 35. 2 39. 1 38. 0 32. 1 34. 1 34. 8 34. 0 41. 8 39. 5 39. 9 37. 8 36. 0 5 38.0 DuPont-4739 1132 ampafty Sanitized. Does not eos8a?n TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): FI Generation Lactation Day 14 Group: VI-0 Dose: 250 mg/kg/day Animal Number 641271 641280a 641252a 6413868 641277 641233 641238 641235 641392b'l= 641360 Pup Sex 1 S 35 .6 9 32 .7 S 5 S 2 S 2 S 40 .0 2 36 .9 S 36 .3 2 33 .4 S 42 .3 2 40 .1 S 32 .7 2 35 .1 S 2 S 40 .0 2 38 .2 Pup Number ---------------- v [ 3 32 .3 34 .5 34 .5 34 .3 38 .0 38 .8 37 .6 34 .2 40 .8 39 .9 35 .4 30 .3 38 .3 38 .2 35 .2 34 .7 38 .2 39 .2 37 .2 34 .0 36 .8 38 .4 40 .1 38 .8 4 34. 3 29. 6 40. 1 38. 5 36. 2 35. 7 41. 2 35. 8 32. 7 38. 5 38. 0 DuPont-4739 1133 Sanfiteed. Oo@ not eontah? TSSCA RR H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): FI Generation Lactation Day 14 Group: VI-0 Dose: 250 mg/kg/day Animal Pup Number Sex 641381s 6413333 Pup Number 234 641239 641228a 38.6 37.1 34.5 39.5 36.6 32.9 34.7 26.3 641334 641347 641367s 30.5 30.7 42.3 41.5 34.1 33.7 39.6 36.7 34.4 30.2 42.7 42.1 34.0 34.2 41.5 41.3 641303 641339 641316 38.5 42.2 39.1 39.1 37.7 39.0 38.5 38.2 39.3 38.1 39.2 39.5 39.8 40.7 39.0 36.1 40.1 35.7 40.6 37.8 38.5 35.1 39.3 37.5 DuPont-4739 1134 ompaffl^ Sanitized. Boss not eonte?n TCCA CT't H-24616: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): PI Generation Lactation Day 14 Group: VIII-0 Dose: 1000 mg/kg/day Animal Number 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 Pup Sex ] L .S 44 .3 ? 38 .2 S 37 .5 ? 35 .6 S 33 .0 9 33 .0 S 34 .9 ? 34 .8 S 39 .0 ? 36 .4 S 38 .9 9 35 .9 S 35 .4 9 35 .6 S 38 .3 ? 36 .2 S 36 .1 S 32 .1 S 40 .2 9 39 .7 2 39. 9 43. 1 34. 4 33. 4 34. 3 34. 5 35. 3 34. 9 37. 8 35. 7 38. 3 34. 8 33. 4 32. 8 39. 1 35. 9 31. 0 32. 0 39. 3 39. 4 Pup Number ---------------- i i 1 39 .6 43 .4 35 .2 32 .3 34 .0 34 .9 30 .8 3.5 .3 32 .4 36 .6 35 .4 38 .9 35 .7 32 .2 36 .1 35 .5 32 .3 34 .3 34 .9 40 .3 39 .9 33 .9 36 .5 33 .6 37 .0 36 .6 37 .2 35 .4 36 .5 35 .0 33 .8 34 .9 32 .9 39 .8 37 .3 5 43.3 ( 41 .8 38.6 DuPont-4739 1135 ampsraySanitized. Does notewta'n T^A ^ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grains) : PI Generation Lactation Day 14 Group: VIII-0 Dose: 1000 mg/kg/day Animal Number 641254 641242s 641284 641230 641273s 641296 641248 641370 641243 641329 Pup Sex S ? S ? S 9 S $ S ? S ? S ? S 9 6 S S 9 3 31 . 6 36 .8 38 .0 37 .4 34 .9 34 .1 36 .9 34 .4 40 .6 36 .4 43 .1 39 .9 35 .3 36 .7 36 .6 33 .8 Pup Number ---------------- ; 3 31 .7 36 .6 39.7 31.9 37 .6 35 .6 33 .6 33 .3 38.2 36.4 34.5 33.6 35 .2 33 .0 39 .2 35 .3 42 .0 41 .6 35 .9 34 .1 34 .4 35 .3 34.7 36.1 40.7 39.3 40.4 39.2 33.8 32.9 33.9 37.1 4 40.8 34.3 42.5 37.5 34.0 33.1 34.3 33.7 42.3 35.5 41.9 39.9 36.4 34.8 35.5 33.6 DuPont-4739 1136 'CwmpswySanNteed. 0es not contain TSCA CB8 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): FI Generation Lactation Day 21 Group: II-O Dose: 0 mg/kg/day Anxmal Pup Number Sex 1 641345 641236 641337 641328 641310 641324 641371 641332 641358s S 65 .4 9 61 .5 S 58 .1 9 58 .3 S 59 .4 ? 62 .8 S 65 .0 S 63 .6 S 56 .4 $ 54 .3 S 69 .5 ? 67 .9 S 64 .5 ? 58 .4 S 54 .8 $ 57 .9 S 9 6413893 S 9 Pup Number ---------------- 2 1 1 4 59 .1 59 .9 64 .8 60 .4 59 .8 58 .7 69 .7 63 .9 59 .2 55 .9 70 .4 65 .5 66 .6 58 .4 57 .9 57 .2 60 .1 57 .6 65 .8 55 .9 63 .9 59 .0 68 .7 59 .8 52 .6 65 .8 67 .9 61 .3 63 .1 57 .4 56 .5 53 .2 65. 6 62. 1 59. 3 51. 2 56. 8 60. 8 63. 4 57.4 60. 0 65. 9 66. 1 53. 0 60. 9 54. 9 56. 6 5 60.8 DuPont-4739 1137 , Does not conte^ re*^ <?? H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individu;al PU) Weights (greims) La.cta tioi1 Dciy 2 1 PI cGeneration Group : II--0 Animal Number 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 Pup Sex 3 S 64 .3 9 62 .2 S 53 .6 ? 51 .0 S 67 .0 S 64 .3 S 66 .0 9 61 .1 S 68 .6 9 62 .5 S 57 .4 9 53 .7 S 61 .0 $ 60 .1 <? 67 .7 9 58 .8 6 62 .8 9 46 .1 S 51 .7 ? 54 .6 DC?se: 0 mg/'kg/day Pulp Nlunbe r ) ^ 1 < \ 5 59 .1 62 .0 58 .7 48 .2 66 .9 67 .4 68 .3 59 .8 68 .4 56 .9 61 .5 62 .7 59 .2 55 .6 59 .0 59 .9 57 .5 61 .6 54 .8 50 .7 63 .7 60 .1 50 .5 50 .0 70 .0 63 .0 66 .2 60 .8 64 .7 58 .6 57 .9 55 .4 52 .6 59 .0 65 .0 59 .4 60 .5 57 .1 53 .4 49 .5 52 .5 50 .7 66 .7 63 .7 61 .2 57 .0 56 .8 58 .1 61 .8 60 .9 66 .9 59 .7 60 .9 54 .5 55 .7 51 .9 61.4 63.9 DuPont-4739 1138 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): FI Generation Lactation Day 21 Group: IV-0 Dose: 50 mg/kg/day Animal Number 641378 641263 641297 641304 641274s 641351 641272 641258 6412763 641350 Pup Sex ] S 60 .6 $ 59 .5 S 57 .2 9 54 .2 S 62 .2 $ 60 .0 S 82 .3 9 72 .2 S 9 S 56 .1 $ 53 .7 S 61 .2 9 53 .8 S 60 .2 ? 53 .1 S 9 S 56 .7 ? 57 .1 Pi-ip N umbe'r ^ i t.1 58 .0 56 .0 56 .2 55 .2 62 .3 63 .9 59 .8 57 .5 56 .1 54 .6 61 .5 62 .4 58 .5 52 .7 54 .2 59 .9 59 .6 72 .4 76 .3 73 .9 52 .5 54 .7 60 .1 62 .4 64 .2 67 .0 51 .4 52 .9 59 .6 55 .3 65 .3 57 .0 50 .2 49 .4 60 .3 52 .1 63 .0 66 .3 64 .4 58 .1 61 .5 57 .7 61 .0 52 .5 5 51.0 65.3 DuPont-4739 1139 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): FI Generation Lactation Day 21 Group: IV-0 Dose: 50 mg/kg/day Animal Number 641376 . 641315 641286 641231 641338 641318 641373 641365 641348 641323 Pup Sex 3 6 54 .4 S 57 .5 6 68 .7 ? 63 .2 S 66 .1 ? 59 .1 S 59 .0 ? 54 .3 S 64 .0 S 59 .8 S 51 .9 9 55 .7 S 61 .7 9 58 .7 S 63 .8 S 58 .8 S 70 .3 S 65 .9 S 57 .5 2 55 .1 Pup Number ---------------- 2 > ! / 1 56 .7 46 .1 63 .0 61 .6 62 .3 61 .5 63 .2 51 .8 63 .9 57 .0 57 .2 55 .6 60 .7 57 .1 59 .6 60 .2 72 .9 63 .7 57 .5 52 .1 54 .7 49 .4 69 .0 67 .8 64 .5 63 .3 61 .5 57 .1 62 .4 60 .0 56 .9 51 .5 62 .5 58 .0 62 .5 55 .7 63 .7 58 .9 53 .3 54 .4 55 .0 62 .5 65 .6 57 .6 57 .9 62 .3 56 .8 58 .3 57 .7 59 .0 51 .4 56 .9 56 .3 61 .7 60 .1 63 .0 54 .3 55 .4 5 59.4 DuPont-4739 1140 Company tmiffzed. Does not contarn TSCA ^ro H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): PI Generation Lactation Day 21 Group: VI-0 Dose: 250 mg/kg/day Animal Number 641271 641280a 641252s 641386a 641277 641233 641238 641235 641392^'c 641360 Pup Sex 3 S 57 .8 9 58 .3 S S S S S 9 S 56 .3 S 58 .6 S 56 .0 S 51 .2 S 61 .1 S 61 .8 S 59 .2 $ 48 .0 S S S 65 .9 9 61 .5 El.^P N umber 2 31 52 .5 46 .9 56 .0 53 .2 59 .4 58 .3 60 .3 54 .4 61 .7 63 .4 54 .2 55 .0 59 .6 56 .2 56 .3 52 .6 70 .1 61 .0 57 .4 51 .6 63 .2 62 .6 66 .6 63 .1 < 1 57 .4 52 .7 61 .2 58 .4 58 .0 56 .0 68 .6 53 .4 56 .0 62 .6 64 .8 DuPont-4739 1141 Company Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): FI Generation Lactation Day 21 Group: VI-0 Dose: 250 mg/kg/day Animal Pup Number Sex i 6413813 S 9 641333a S S 641239 6412283 S 57 .8 9 58 .1 S S 641334 S 61 .4 9 57 .3 641347 S 72 .0 $ 67 .3 6413673 S $ 641303 641339 641316 a 62 .5 s 58 .2 s 63 .7 $ 61 .4 s 60 .8 s 59 .2 PLip M Lirobe r > i 59 .7 60 .3 55 .6 52 .7 58 .3 51 .1 62 .3 61 .7 54 .6 55 .5 69 .3 69 .0 62 .2 61 .2 62 .0 59 .3 63 .1 56 .7 63 .2 64 ,7 60 .5 57 .3 63 .3 60 .5 4', 64 .0 41 .5 59 .9 58 .9 68 .7 64 .1 63 .3 56 .4 60 .2 61 .9 63 .5 60 .6 DuPont-4739 1142 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): FI Generation Lactation Day 21 Group: VIII-0 Animal Number 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 Pup Sex 3 S 71 .3 ? 65 .4 S 56 .4 9 52 .4 3 56 .6 9 52 .0 S 56 .3 S 56 .0 S 62 .5 2 58 .2 S 61 .6 ? 56 .5 S 56 .0 9 54 .6 S 55 .6 9 51 .8 S 54 .9 9 56 .8 S 62 .9 ? 64 .9 ; 67 .5 60 .2 54 .8 56 .9 57 .3 52 .2 57 .6 52 .1 58 .8 57 .6 61 .5 53 .4 55 .2 48 .8 62 .3 55 .9 55 .6 58 .3 65 .3 64 .4 Dose: 1000 mg/kg/day Pup Mumber ---------------- ! / \. 68 .5 64 .6 C 64 .0 6 62.2 56 .1 53 .7 59 .1 54 .8 56 .7 56 .7 54 .2 59 .7 56 .0 61 .6 54 .1 53 .7 54 .8 63 .6 56 .2 58 .3 53 .2 65 .7 60 .6 50 .0 53 .8 52 .6 59 .9 54 .6 57 .7 55 .3 50 .1 52 .8 54 .8 53 .0 53 .8 66 .3 64 .2 62 .5 DuPont-4739 1143 Company SanSlfced. Does not contain TSC-A CB! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): FI Generation Lactation Day 21 Group: VIII-0 Dose: 1000 mg/kg/day Animal Number 641254 6412423 641284 641230 641273s 641296 641248 641370 641243 641329 Pup Sex S 9 S S S S S 9 S 9 S 9 S 9 S 9 S 9 S 9 31. 65 .0 51 .9 64 .7 59 .9 55 .7 52 .3 52 .8 50 .8 64 .7 56 .2 62 .0 59 .0 61 .3 54 .7 54 .3 53 .4 Pup Mturiber j 3 53 .6 57 .7 63. 8 56. 3 4 1 53 .0 55 .6 64 .4 62 .7 53 .6 54 .0 62. 4 60. 4 59. 1 54. 4 67 .0 58 .7 55 .7 52 .7 56 .0 50 .0 64 .8 58 .5 69 .0 60 .9 60 .7 55 .1 56 .8 56 .0 56. 2 55. 0 61. 9 58. 3 64. 4 64. 0 57. 3 61. 0 54. 2 50. 4 53 .0 51 .2 63 .4 61 .2 62 .2 56 .9 62 .5 51 .0 55 .0 52 .3 DuPont-4739 1144 Sanitized. Does not eontain TSCA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 APPENDIX FF REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fi GENERATION 1145 Sanitized,. Does i H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ______DuPont-4739 REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fi GENERATION EXPLANATORY NOTES Footnotes a All pups were dead prior to lactation day 7. 1146 Company Sanitized. Does not contain TSCA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL NUMBER INDIVIElUAL LITTER CLINICAL OBSERVATIC)NS: Pi GENERATION GROUP: II-O DOSE: 0 MG /KG/DAY LACTATION DAY SIGN INCIDENCE OBSERVATIONS 641345 641236 641337 641328 641310 641324 641371 641332 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 1147 Sanitized. Does not contain TSCA r'7,'l H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL NUMBER IMDIVI DUAL LITTER CLINICAL OBSERVATIC)NS: Fi GENERATION GROUP: IV-0 DOSE: 50 MGi/KG/DAY LACTATION DAY SIGN INCIDENCE OBSERVATIONS 641378 / NO ABNORMALITIES DETECTED 641263 NO ABNORMALITIES DETECTED 641297 NO ABNORMALITIES DETECTED 641304 NO ABNORMALITIES DETECTED 641351 NO ABNORMALITIES DETECTED 641272 NO ABNORMALITIES DETECTED 641258 NO ABNORMALITIES DETECTED 641350 MO ABNORMALITIES DETECTED 641376 NO ABNORMALITIES DETECTED 641315 NO ABNORMALITIES DETECTED 641286 NO ABNORMALITIES DETECTED 641231 NO ABNORMALITIES DETECTED 641338 NO ABNORMALITIES DETECTED 641318 NO ABNORMALITIES DETECTED 641373 DAY 0 1 OP 16 SWOLLEN HEAD LITTER SUMMARY : 1 SWOLLEN HEAD 641365 NO ABNORMALITIES DETECTED 641348 NO ABNORMALITIES DETECTED 641323 NO ABNORMALITIES DETECTED 1148 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL NUMBER INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fi GENERATION GROUP: VI-0 DOSE: 250 MG/KG/DAY LACTATION DAY SIGN INCIDENCE OBSERVATIONS 641271 641277 641233 641238 641235 6413923 641360 641239 641334 641347 641303 641339 641316 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 1149 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL NUMBER INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fi GENERATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY LACTATION DAY SIGN INCIDENCE OBSERVATIONS 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 DAY 21 1 OF 8 LITTER SUMMARY: I 641284 641230 641296 641248 641370 641243 641329 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED HO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED MO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED CORNEAL OPACITY LEFT EYE(S) CORNEAL OPACITY NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 1150 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______._______DuPont-4739 APPENDIX GG REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHTS; Fi GENERATION 1151 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 REPRODUCTIVB TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHTS: Fi GENERATION EXPLANATORY NOTES Notes Day of weaning = Test Day 1. 1152 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Fi MALE BATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644438 644439 644440 644441 644442 644443 644444 644445 644446 644447 644448 644449 644450 644451 644452 644453 644454 644455 1 8 15 22 29 36 43 65 .6 59 .3 60 .8 60 .8 57 .4 65 .9 53 .0 54 .9 63 .7 52 .5 66 .7 66 .2 64 .7 56 .8 61 .8 66 .9 60 .9 55 .7 106 .7 101 .1 107 .5 112 .8 97 .4 109 .5 98 .4 96 .7 104 .5 95 .5 108 .9 104 .9 110 .3 99 .2 102 .7 110 .9 114 .4 95 .0 172 .5 163 .5 167 .0 184 .0 159 .8 167 .0 157 .7 165 .5 180 .3 153 .8 174 .1 167 .2 174 .0 156 .7 169 .4 183 .4 178 .1 159 .0 227 .0 216 .1 233 ,9 264 .6 207 .5 205 .8 219 .3 234 .0 268 .3 215 .4 230 .5 223 .8 237 .3 211 .7 211 .1 254 .0 240 .8 228 .9 299 .1 280 .0 282 .1 336 .7 271 .3 272 .1 281 .2 295 .6 338 .3 281 .9 326 .2 291 .3 297 .5 267 .7 294 .5 308 .3 306 .3 285 .5 365 .0 332 .9 343 .1 413 .9 326 .4 335 .2 347 .4 362 .0 407 .6 341 .4 395 .3 351 .9 354 .4 330 .7 367 .3 363 .2 372 .2 335 .6 404.8 390.2 387.4 477.2 373.4 388-. 5 398.2 412.6 483.4 389.7 453.8 415.4 398.5 378.2 428.5 401.8 423.0 376.2 1153 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 DAYS ON TEST: ANIMAL NUMBER 644508 644509 644510 644511 644512 644513 644514 644515 644516 644517 644518 644519 644520 644521 644522 644523 644524 644525 INDIVIDUAL BODY WEIGHTS (grams) OP Fi MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY 15 22 29 36 58.5 56.1 59.9 82.3 50.2 60.3 63.0 61.0 55.0 62.5 57.6 62.3 58.3 59.0 56.9 59.4 60.1 54.3 108 .9 100 .6 113 .8 136 .3 87 .8 107 .7 103 .8 112 .2 96 .4 102 .0 102 .7 107 .4 101 .3 102 .6 103 .8 104 .7 97 .2 105 .7 176 .8 167 .3 175 .8 212 .1 148 .3 172 .8 165 .3 181 .3 156 .2 167 .2 167 .9 185 .0 161 .8 170 .8 163 .7 172 .5 161 .9 175 .8 226 .7 230 .1 259 .1 281 .5 205 .2 239 .3 230 .1 238 .9 200 .0 232 .5 233 .6 259 .5 222 .8 235 .7 220 .4 244 .8 223 .5 207 .1 322 .9 295 .1 328 .9 353 .5 277 .0 299 .1 290 .6 288 .5 262 .0 293 .7 293 .7 322 .0 285 .2 299 .7 271 .8 316 .2 290 .6 305 .9 399 .2 362 .8 392 .1 417 .7 345 .1 360 .0 345 .4 341 .5 319 .4 363 .3 366 .6 361 .0 345 .5 361 .7 317 .6 383 .4 370 .6 367 .3 43 468.4 429.1 459.2 481.4 403.8 413.7 398.1 390.5 368.7 421.3 421.4 422.1 409.3 408.8 361.2 434.3 431.8 428.6 1154 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL-BODY WEIGHTS (grams) OF Fi MALE RATS GROUP: V-l DOSE: 250 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644577 644578 644579 644580 644581 644582 644583 644584 644585 644586 644587 644588 1 15 22 29 36 61.2 57.4 58.0 68.6 53.4 62.6 64.0 59.9 68.7 63.3 60.2 63.5 103 .2 99 .4 97 .2 114 .1 87 .6 103 .8 108 .3 104 .0 110 .3 111 .7 107 .5 98 .9 162 .6 168 .7 154 .3 184 .5 143 .2 173 .3 172 .7 168 .9 172 .4 180 .7 170 .9 161 .1 224 .6 223 .9 198 .7 236 .7 192 .6 231 .6 243 .1 232 .1 239 .1 250 .5 225 .3 222 .8 282 .9 300 .1 268 .7 329 .9 232 .1 283 .3 313 .1 293 .2 299 .5 310 .0 307 .0 281 .3 330 .1 374 .5 322 .5 414 .6 276 .9 330 .8 377 .5 356 .2 358 .6 365 .2 372 .0 322 .6 43 382.3 425.1 373.6 465.8 314.5 376.5 431.7 379.4 413.9 405.6 428.3 358.5 1155 Company Sanitized. Does not eontain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Fi MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644625 644626 644627 644628 644629 644630 644631 644632 644633 644634 644635 644636 644637 644638 644639 644640 644641 644642 15 22 29 36 62 .2 59 .1 57 .3 53 .8 59 .9 57 .7 50 .1 62 .5 53 .0 66 .3 53 .0 67 .0 55 .7 53 .0 63 .4 62 .2 62 .5 55 .0 116.2 104.2 96.6 91.6 110.7 97.6 80.9 103.3 94.4 112.9 86.5 109.9 98.6 93.1 110.4 113.2 103.8 90.1 185.8 170.4 155.2 149.1 176.4 151.0 135.0 160.4 154.5 174.5 150.9 179.7 157.2 153.0 179.2 183.7 168.6 146.5 261. 0 229. 1 224. 8 207. 6 240. 7 210. 4 193. 1 223. 9 206. 3 241. 6 218. 9 239. 6 195. 0 212. 2 245. 9 251. 3 230. 9 204. 2 325.6 300.3 287.9 265.6 304.6 268.4 244.0 282.1 295.2 308.1 287.3 319.0 262.0 266.6 306.8 312.8 289.7 248.1 401.7 355.0 345.9 316.9 364.1 320.4 304.0 336.4 361.7 366.9 351.7 398.1 330.2 329.9 367.4 366.7 346.4 297.0 43 457.2 406.2 395.2 366.6 413.2 365.8 344.3 389.9 423.3 414.0 403.9 458.3 382.7 379.9 424.3 413.0 402.4 344.9 1156 Company Sanitteed. Does not conSain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study inRats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL. BODY WEIGHTS (grams) OF Pi FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644698 644699 644700 644701 644702 644703 644704 644705 644706 644707 644708 644709 644710 644711 644712 644713 644714 644715 15 22 29 36 62.1 51.2 59.0 63.4 60.0 66.1 60.9 56.6 60.1 50.7 63.7 61.4 63.9 58.1 60.9 59.7 54.5 51.9 102 .1 93 .4 97 .0 102 .5 98 .0 97 .5 105 .2 95 .7 101 .5 96 .8 98 .4 101 .8 102 .3 97 .0 91 .8 107 .1 92 .7 88 .7 152 .0 136 .9 134 .6 149 .5 149 .0 140 .0 144 .5 148 .9 142 .3 145 .1 146 .3 150 .2 154 .7 146 .1 138 .5 156 .2 137 .0 128 .5 181 .8 161 .3 184 .5 198 .6 182 .0 178 .8 191 .2 190 .3 178 .3 185 .1 191 .6 184 .0 187 .8 179 .5 174 .6 194 .4 169 .6 165 .8 202 .6 189 .9 212 .7 217 .8 202 .4 206 .8 221 .0 219 .3 196 .9 205 .9 227 .3 207 .0 205 .0 208 .0 202 .7 216 .8 194 .2 181 .8 221 .5 209 .9 233 .9 249 .9 223 .5 230 .5 253 .5 246 .5 220 .4 233 .7 245 .2 228 .8 229 .1 225 .5 217 .8 232 .4 212 .3 212 .0 43 238 .0 231 .1 252 .9 278 .4 242 .6 260 .'4 271 .4 256 .9 240 .4 254 .9 270 .7 245 .0 245 .0 231 .3 252 .9 245 .6 230 .6 213 .1 1157 Company Sanitized. Does not contain TCCA CB' H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Pi FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644770 644771 644772 644773 644774 644775 644776 644777 644778 644779 644780 644781 644782 644783 644784 644785 644786 644787 1 - 8 15 22 29 36 43 52 .7 51 .0 59 .6 65 .3 49 .4 52 .1 66 .3 52 .5 49 .4 65 .6 57 .9 56 .8 57 .7 51 .4 56 .3 55 .7 63 .0 55 .4 93 .3 86 .3 91 .8 103 .9 88 .4 85 .9 100 .1 96 .0 85 .4 101 .3 101 .5 101 .1 92 .5 89 .3 102 .7 93 .5 101 .7 99 .4 140 .8 129 .2 136 .8 158 .3 141 .0 127 .5 145 .8 146 .3 124 .0 151 .6 148 .2 155 .0 134 .0 143 .0 149 .1 140 .5 162 .4 154 .3 173 .7 163 .4 170 .6 204 .3 177 .3 165 .3 175 .3 176 .8 157 .2 165 .4 186 .8 193 .4 164 .4 186 .8 174 .4 177 .2 189 .9 198 .4 206 .8 184 .9 201 .1 231 .7 206 .8 190 .2 203 .9 201 .1 184 .3 174 .7 214 .1 217 .2 174 .6 211 .7 213 .4 200 .0 231 .8 225 .8 225 .1 197 .3 223 .8 256 .1 233 .8 205 .5 223 .1 218 .1 207 .5 204 .8 246 .9 238 .6 190 .9 240 .9 228 .1 222 .1 270 .1 259 .2 249.7 225.9 251.0 285.1 249.0 231-.3 241.4 235.2 222.1 216.1 269.1 257.1 206.5 272.6 255.4 235.3 302.8 273.1 1158 Cwaywy SaiiBfaetf. Doess not contain JSCA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Fi FEMALE RATS GROUP: VI-1 DOSE: 250 MG/KG/DAY OBTEST: AMIMAL NUMBER 644842 644843 644844 644845 644846 644847 644848 644849 644850 644851 644852 644853 1 8 15 22 29 36 43 52.7 58.4 56.0 61.0 50.6 64.8 41.5 58.9 64.1 56.4 61.9 60.6 92.5 99.2 91.4 96.1 88.5 103.6 73.2 96.8 113.0 100.4 103.5 93.6 145.7 151.8 139.6 140.1 137.5 158.3 115.1 139.5 166.5 146.4 157.5 139.0 183.9 197.9 175.7 177.5 170.8 204.3 147.4 169.1 206.5 180.6 204.9 170.8 186.3 228.1 200.5 201.3 193.3 227.4 174.6 208.3 235.9 202.0 228.7 186.4 206.2 254.2 228.8 220.2 215.2 257.4 196.2 224.5 275.6 218.0 252.8 198.4 211.4 283.7 251.3 234.9 238.5 285.8 216.3 243.7 312.7 233.5 287.7 215.3 1159 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OP Fi FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644889 644890 644891 644892 644893 644894 644895 644896 644897 644898 644899 644900 644901 644902 644903 644904 644905 644906 15 22 29 36 60 .2 54 .8 50 .0 52 .6 54 .6 55 .3 52 .8 56 .2 53 .8 64 .2 55 .6 58 .7 52 .7 51 .2 61 .2 56 .9 51 .0 52 .3 100 .5 95 .1 88 .0 86 .3 93 .5 87 .7 87 .3 86 .5 89 .4 104 .5 90 .2 97 .9 96 .9 87 .4 97 .8 101 .7 85 .5 89 .4 151 .1 141 .8 129 .3 130 .6 142 .2 122 .6 134 .2 139 .2 135 .1 154 .2 136 .6 153 .0 150 .8 134 .9 138 .0 147 .5 134 .3 136 .5 186 .3 175 .0 177 .7 168 .3 175 .2 154 .1 171 .3 179 .3 176 .9 183 .5 172 .8 187 .9 187 .5 161 .2 174 .8 178 .9 172 .8 161 .6 207 .6 185 .1 206 .2 189 .3 197 .8 172 .7 195 .7 204 .2 202 .0 214 .1 201 .7 214 .4 213 .2 182 .6 198 .4 197 .5 205 .3 174 .2 239 .9 198 .4 227 .7 216 .1 216 .7 188 .0 239 .7 226 .5 229 .8 242 .6 223 .4 243 .7 251 .9 204 .3 222 .1 220 .5 231 .5 211 .4 43 258 .0 203 .9 247 .9 228 .0 228 .6 210 .0 249 .7 248 .5 245 .0 257 .8 241 .6 265 .0 259 .8 229 .4 242 .5 238 .1 248 .5 218 .9 1160 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 APPENDIX HH REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHT GAINS: Fi GENERATION 1161 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHT GAINS: Fi GENERATION EXPLANATORY NOTES Notes Day of weaning == Test Day 1. DuPont-4739 1162 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644438 644439 644440 644441 644442 644443 644444 644445 644446 644447 644448 644449 644450 644451 644452 644453 644454 644455 1-8 41 .1 41 .8 46 .7 52 .0 40 .0 43 .6 45 .4 41 .8 40 .8 43 .0 42 .2 38 .7 45 .6 42 .4 40 .9 44 .0 53 .5 39 .3 8-15 15-22 22-29 29-36 36-43 65 .8 62 .4 59 .5 71 .2 62 .4 57 .5 59 .3 68 .8 75 .8 58 .3 65 .2 62 .3 63 .7 57 .5 66 .7 72 .5 63 .7 64 .0 54 .5 52 .6 66 .9 80 .6 47 .7 38 .8 61 .6 68 .5 88 .0 61 .6 56 .4 56 .6 63 .3 55 .0 41 .7 70 .6 62 .7 69 .9 72 .1 63 .9 48 .2 72 .1 63 .8 66 .3 61 .9 61 .6 70 ,0 66 .5 95 .7 67 .5 60 .2 56 .0 83 .4 54 .3 65 .5 56 .6 65 .9 52 .9 61 .0 77 .2 55 .1 63 .1 66 .2 66 .4 69 .3 59 .5 69 .1 60 .6 56 .9 63 .0 72 .8 54 .9 65 .9 50 .1 39 .8 57 .3 44 .3 63 .3 47 .0 53 .3 50 .8 50 .6 75 .8 48 .3 58 .5 63 .5 44 .1 47 .5 61 .2 38 .6 50 .8 40 .6 1163 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fi MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644508 644509 644510 644511 644512 644513 644514 644515 644516 644517 644518 644519 644520 644521 644522 644523 644524 644525 1-8 50 .4 44 .5 53 .9 54 .0 37 .6 47 .4 40 .8 51 .2 41 .4 39 .5 45 .1 45 .1 43 .0 43 .6 46 .9 45 .3 37 .1 51 .4 8-15 15-22 22-29 29-36 36-43 67 .9 66 .7 62 .0 75 .8 60 .5 65 .1 61 .5 69 .1 59 .8 65 .2 65 .2 77 .6 60 .5 68 .2 59 .9 67 .8 64 .7 70 .1 49 .9 62 .8 83 .3 69 .4 56 .9 66 .5 64 .8 57 .6 43 .8 65 .3 65 .7 74 .5 61 .0 64 .9 56 .7 72 .3 61 .6 31 .3 96 .2 65 .0 69 .8 72 .0 71 .8 59 .8 60 .5 49 .6 62 .0 61 .2 60 .1 62 .5 62 .4 64 .0 51 .4 71 .4 67 .1 98 .8 76 .3 67 .7 63 .2 64 .2 68 .1 60 .9 54 .8 53 .0 57 .4 69 .6 72 .9 39 .0 60 .3 62 .0 45 .8 67 .2 80 .0 61 .4 69 .2 66 .3 67 .1 63 .7 58 .7 53 .7 52 .7 49 .0 49 .3 58 .0 54 .8 61 .1 63 .8 47 .1 43 .6 50 .9 61 .2 61 .3 1164 Company Sanitized. Does not contain TSCA CBE H-24616: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OP Fi MALE RATS GROUP: V-l DOSE: 250 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644577 644578 644579 644580 644581 644582 644583 644584 644585 644586 644587 644588 1-8 8-15 15-22 22-29 29-36 36-43 42.0 42.0 39.2 45.5 34.2 41.2 44.3 44.1 41.6 48.4 47.3 35.4 59.4 69.3 57.1 70.4 55.6 69.5 64.4 64.9 62.1 69.0 63.4 62.2 62.0 55.2 44.4 52.2 49.4 58.3 70.4 63.2 66.7 69.8 54.4 61.7 58.3 76.2 70.0 93.2 39.5 51.7 70.0 61.1 60.4 59.5 81.7 58.5 47.2 74.4 53.8 84.7 44.8 47.5 64.4 63.0 59.1 55.2 65.0 41.3 52.2 50.6 51.1 51.2 37.6 45.7 54.2 23.2 55.3 40.4 56.3 35.9 1165 SfOmpmy Sanitized. Does not contain' H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF F^ MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644625 644626 644627 644628 644629 644630 644631 644632 644633 644634 644635 644636 644637 644638 644639 644640 644641 644642 1-8 54. 0 45. 1 39. 3 37'. 8 50. 8 39. 9 30. 8 40. 8 41. 4 46. 6 33. 5 42. 9 42. 9 40. 1 47. 0 51. 0 41. 3 35. 1 8-15 15-22 22-29 29-36 36-43 69 .6 66 .2 58 .6 57 .5 65 .7 53 .4 54 .1 57 .1 60 .1 61 .6 64 .4 69 .8 58 .6 59 .9 68 .8 70 .5 64 .8 56 .4 75 .2 58 .7 69 .6 58 .5 64 .3 59 .4 58 .1 63 .5 51 .8 67 .1 68 .0 59 .9 37 .8 59 .2 66 .7 67 .6 62 .3 57 .7 64 .6 71 .2 63 .1 58 .0 63 .9 58 .0 50 .9 58 .2 88 .9 66 .5 68 .4 79 .4 67 .0 54 .4 60 .9 61 .5 58 .8 43 .9 76 .1 54 .7 58 .0 51 .3 59 .5 52 .0 60 .0 54 .3 66 .5 58 .8 64 .4 79 .1 68 .2 63 .3 60 .6 53 .9 56 .7 48 .9 55 .5 51 .2 49 .3 49 .7 49 .1 45 .4 40 .3 53 .5 61 .6 47 .1 52 .2 60 .2 52 .5 50 .0 56 .9 46 .3 56 .0 47 .9 1166 Company Sanitized. Does not conSain TSCA CB6 H-24616: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644698 644699 644700 644701 644702 644703 644704 644705 644706 644707 644708 644709 644710 644711 644712 644713 644714 644715 1-8 40 .0 42 .2 38 .0 39 .1 38 .0 31 .4 44 .3 39 .1 41 .4 46 .1 34 .7 40 .4 38 .4 38 .9 30 .9 47 .4 38 .2 36 .8 8-15 15-22 22-29 29-36 36-43 49 .9 43 .5 37 .6 47 .0 51 .0 42 .5 39 .3 53 .2 40 .8 48 .3 47 .9 48 .4 52 .4 49 .1 46 .7 49 .1 44 .3 39 .8 29 .8 24 .4 49 .9 49 .1 33 .0 38 .8 46 .7 41 .4 36 .0 40 .0 45 .3 33 .8 33 .1 33 .4 36 .1 38 .2 32 .6 37 .3 20 .8 28 .6 28 .2 19 .2 20 .4 28 .0 29 .8 29 .0 18 .6 20 .8 35 .7 23 .0 17 .2 28 .5 28 .1 22 .4 24 .6 16 .0 18 .9 20 .0 21 .2 32 .1 21 .1 23 .7 32 .5 27 .2 23 .5 27 .8 17 .9 21 .8 24 .1 17 .5 15 .1 15 .6 18 .1 30 .2 16 .5 21 .2 19 .0 28 .5 19 .1 29 .9 17 .9 10 .4 20 .0 21 .2 25 .5 16 .2 15 .9 5 .8 35 .1 13 .2 18 .3 1 .1 1167 Company Santtized. Does not contain TSCA CE H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fi FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644770 644771 644772 644773 644774 644775 644776 644777 644778 644779 644780 644781 644782 644783 644784 644785 644786 644787 1-t 40 .6 35 .3 32 .2 38 .6 39 .0 33 .8 33 .8 43 .5 36 .0 35 .7 43 .6 44 .3 34 .8 37 .9 46 .4 37 .8 38 .7 44 .0 8-15 15-22 22-29 29-36 36-43 47 .5 42 .9 45 .0 54 .4 52 .6 41 .6 45 .7 50 .3 38 .6 50 .3 46 .7 53 .9 41 .5 53 .7 46 .4 47 .0 60 .7 54 .9 32 .9 34 .2 33 .8 46 .0 36 .3 37 .8 29 .5 30 .5 33 .2 13 .8 38 .6 38 .4 30 .4 43 .8 25 .3 36 .7 27 .5 44 .1 33 .1 21 .5 30 .5 27 .4 29 .5 24 .9 28 .6 24 .3 27 .1 9 .3 27 .3 23 .8 10 .2 24 .9 39 .0 22 .8 41 .9 27 .4 18 .3 12 .4 22 .7 24 .4 27 .0 15 .3 19 .2 17 .0 23 .2 30 .1 32 .8 21 .4 16 .3 29 .2 14 .7 22 .1 38 .3 33 .4 24 .6 28 .6 27 .2 29 .0 15 .2 25 .8 18 .3 17 .1 14 .6 11 .3 22 .2 18 .5 15 .6 31 .7 27 .3 13 .2 32 .7 13 .9 1168 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ____________DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fi FEMALE RATS GROUP: VI-1 DOSE: 250 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644842 644843 644844 644845 644846 644847 644848 644849 644850 644851 644852 644853 1-8 8-15 15-22 22-29 29-36 36-43 39.8 40.8 35.4 35.1 37.9 38.8 31.7 37.9 48.9 44.0 41.6 33.0 53.2 52.6 48.2 44.0 49.0 54.7 41.9 42.7 53.5 46.0 54.0 45.4 38.2 46.1 36.1 37.4 33.3 46.0 32.3 29.6 40.0 34.2 47.4 31.8 2.4 30.2 24.8 23.8 22.5 23.1 27.2 39.2 29.4 21.4 23.8 15.6 19.9 26.1 28.3 18.9 21.9 30.0 21.6 16.2 39.7 16.0 24.1 12.0 5.2 29.5 22.5 14.7 23.3 28.4 20.1 19.2 37.1 15.5 34.9 16.9 1169 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644889 644890 644891 644892 644893 644894 644895 644896 644897 644898 644899 644900 644901 644902 644903 644904 644905 644906 1-8 40 .3 40 .3 38 .0 33 .7 38 .9 32 .4 34 .5 30 .3 35 .6 40 .3 34 .6 39 .2 44 .2 36 .2 36 .6 44 .8 34 .5 37 .1 8-15 15-22 22-29 29-36 36-43 50 .6 46 .7 41 .3 44 .3 48 .7 34 .9 46 .9 52 .7 45 .7 49 .7 46 .4 55 .1 53 .9 47 .5 40 .2 45 .8 48 .8 47 .1 35 .2 33 .2 48 .4 37 .7 33 .0 31 .5 37 .1 40 .1 41 .8 29 .3 36 .2 34 .9 36 .7 26 .3 36 .8 31 .4 38 .5 25 .1 21.3 10.1 28.5 21.0 22.6 18.6 24.4 24.9 25.1 30.6 28.9 26.5 25.7 21.4 23.6 18.6 32.5 12.6 32.3 13.3 21.5 26.8 18.9 15.3 44.0 22.3 27.8 28.5 21.7 29.3 38.7 21.7 23.7 23.0 26.2 37.2 18.1 5.5 20.2 11.9 11.9 22.0 10.0 22.0 15.2 15.2 18.2 21.3 7.9 25.1 20.4 17.6 17.0 7.5 1170 ! noSeontaIn TSCA cm H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______,______DuPont-4739 APPENDIX II REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL FOOD CONSUMPTION; Fi GENERATION 1171 .ompany Saralteed. Does not contain TSCA CB( H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL FOOD CONSUMPTION: Fi GENERATION EXPLANATORY NOTES Notes Day of weaning = Test Day 1. 1172 ecMnpany SanlUzed, Does no8 eontain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fi MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644438 644439 644440 644441 644442 644443 644444 644445 644446 644447 644448 644449 644450 644451 644452 644453 644454 644455 1-8 13 .8 14 .2 14 .6 15 .7 12 .9 14 .5 13 .1 13 .2 13 .4 13 .0 13 .6 14 .4 14 .7 12 .7 13 .4 15 .0 14 .8 12 .7 8-15 15-22 22-29 29-36 36-43 22 .0 21 .9 21 .6 22 .2 20 .4 22 .4 19 .9 20 .5 22 .6 19 .1 21 .1 19 .4 21 .8 20 .6 20 .0 24 .6 22 .1 21 .0 25.8 25.6 25.7 27.9 24.3 19.1 25.3 25.4 28.2 22.9 25.8 23.8 25.4 23.8 22.3 27.2 27.4 25.6 31 .5 28 .3 27 .6 32 .1 27 .2 28 .0 29 .9 29 .2 32 .5 27 .6 34 .1 28 .5 30 .8 29 .0 29 .9 30 .1 32 .9 28 .1 31 .3 30 .3 30 .5 35 .1 32 .0 29 .3 30 .7 32 .3 33 .0 29 .3 36 .0 32 .0 30 .2 31 .4 32 .3 32 .7 33 .9 30 .8 31.6 31.1 31.0 37.1 30.1 29.4 30.7 35.0 39.6 28.7 36.7 35.1 30.4 32.8 34.8 32.0 32.6 29.6 1173 ir^ui^^^^, Of*^o^j H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fi MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644508 644509 644510 644511 644512 644513 644514 644515 644516 644517 644518 644519 644520 644521 644522 644523 644524 644525 1-8 16 .0 12 .9 16 .1 16 .7 11 .9 15 .2 14 .0 15 .7 12 .1 13 .0 13 .2 13 .2 13 .7 12 .8 13 .5 14 .8 12 .5 15 .1 8-15 15-22 22-29 29-36 36-43 24 .7 21 .7 23 .1 25 .7 19 .8 22 .1 20 .7 22 .6 18 .9 20 .0 21 .2 22 .3 20 .9 20 .0 20 .8 23 .1 20 .5 23 .9 27 .5 26 .0 29 .4 28 .2 23 .3 26 .1 27 .8 26 .9 18 .4 25 .8 26 .3 28 .1 24 .5 25 .4 24 .5 27 .1 25 .8 26 .5 36 .3 31 .2 33 .8 32 .5 29 .5 30 .0 29 .4 27 .9 26 .6 28 .3 29 .9 30 .8 28 .8 30 .6 27 .3 31 .9 30 .2 37 .2 37 .7 34 .0 35 .0 34 .5 30 .6 32 .1 31 .2 29 .0 29 .0 30 .3 31 .7 25 .9 31 .6 32 .2 28 .1 34 .0 35 .7 34 .4 40 .6 37 .3 39 .6 35 .9 31 .8 33 .8 31 .2 28 .5 29 .7 33 .1 31 .6 34 .3 34 .2 34 .2 28 .5 33 .8 37 .7 35 .2 1174 H-24616: SubchronicToxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY F]. MALE RATS GROUP: V-l DOSE: 250 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644577 644578 644579 644580 644581 644582 644583 644584 644585 644586 644587 644588 1-8 8-15 15-22 22-29 29-36 36-43 12.0 12.7 12.6 15.8 12.6 13.5 14.8 17.8 13.6 15.2 14.0 15.4 19.1 22.8 19.0 24.0 19.7 18.1 22.8 18.9 22.8 23.6 22.6 21.7 22.3 25.8 22.5 27.3 22.7 23.9 27.0 24.7 26.5 28.3 25.8 26.9 25.8 33.0 28.7 35.1 26.9 27.1 31.3 27.9 28.8 30.6 32.4 29.5 26.8 34.5 29.0 39.0 29.6 27.0 34.7 30.5 31.8 31.6 33.6 29.7 28.4 34.8 29.8 36.8 29.8 28.3 35.0 28.3 31.7 31.3 34.9 28.3 1175 Company ganfHzed. Does not contain TRCA ^| H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ., DuPont-4739 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Pi MALE RATS GROUP: VI I-1 DOSE: 1000 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644625 644626 644627 644628 644629 644630 644631 644632 644633 644634 644635 644636 644637 644638 644639 644640 644641 644642 1-8 14 .8 13 .5 13 .9 11 .7 14 .4 13 .1 10 .9 13 .3 12 .6 16 .0 11 .4 13 .9 13 .1 12 .1 15 .1 14 .2 13 .3 12 .9 8-15 15-22 22-29 29-36 36-43 22.3 21.8 22.7 20.1 22.5 18.7 16.7 21.1 20.8 21.3 20.5 21.5 18.5 18.3 22.9 23.3 19.8 18.2 29.3 26.5 26.4 21.7 27.4 23.5 25.4 24.7 24.8 26.2 25.7 27.7 19.9 21.5 27.7 27.7 23.8 23.4 32 .6 32 .5 30 .1 25 .4 31 .1 28 .3 23 .6 28 .0 32 .5 29 .2 32 .2 32 .6 30 .6 24 .8 31 .7 32 .6 26 .3 24 .6 35 .6 31 .9 31 .7 27 .4 34 .1 27 .9 27 .9 29 .9 34 .0 31 .9 34 .1 34 .3 34 .2 27 .0 33 .9 34 .0 27 .9 27 .3 36 .8 34 .3 32 .5 28 .6 31 .3 29 .2 28 .7 16 .9 37 .4 31 .1 35 .5 35 .8 36 .9 27 .9 33 .4 33 .2 29 .2 29 .2 1176 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Pi FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644698 644699 644700 644701 644702 644703 644704 644705 644706 644707 644708 644709 644710 644711 644712 644713 644714 644715 1-8 13 .8 14 .2 14 .0 13 .0 18 .1 14 .3 9 .1 13 .5 17 .5 13 .5 12 .9 14 .0 12 .9 12 .1 10 .3 14 .4 10 .7 12 .4 8-15 15-22 22-29 29-36 36-43 19 .5 18 .1 18 .9 19 .6 18 .0 18 .2 20 .3 19 .8 17 .7 19 .3 18 .7 18 .8 18 .2 19 .2 16 .8 20 .7 17 .4 17 .3 20 .0 17 .8 18 .5 21 .8 20 .7 19 .5 23 .5 23 .6 18 .5 21 .3 21 .1 19 .9 19 .0 21 .5 20 .0 21 .2 18 .3 19 .4 20 .6 21 .6 22 .5 22 .2 21 .4 21 .5 23 .8 24 .1 19 .1 22 .0 23 .9 20 .8 19 .7 22 .8 20 .7 22 .2 19 .5 19 .9 19 .1 20 .8 22 .2 23 .8 19 .8 22 .5 25 .4 24 .2 19 .7 23 .3 21 .9 20 ,1 20 .6 21 .4 18 .1 21 .1 19 .6 20 .5 19 .4 21 .4 25 .4 24 .9 20 .6 23 .5 26 .5 23 .6 18 .9 22 .6 23 .2 19 .3 20 .2 23 .7 21 .8 19 .9 19 .1 20 .9 1177 Company Sanitized. Does not eontain TSCA CBt H-24616: Subchronic Toxicity 90-pay Gavage Study in Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 INDIVIDUAL POOD CONSUMPTION (grams/day) BY Fi FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644770 644771 644772 644773 644774 644775 644776 644777 644778 644779 644780 644781 644782 644783 644784 644785 644786 644787 1-8 12 .7 12 .5 12 .2 12 .7 11 .6 10 .6 12 .8 11 .7 13 .7 13 .1 13 .7 13 .4 11 .9 11 .5 14 .1 13 .0 13 .6 13 .3 8-15 15-22 22-29 29-36 36-43 19.3 17.3 18.3 21.5 19.9 16.4 16.9 19.2 15.2 19.5 18.9 19.3 17.5 17.5 19.9 19.0 20.9 20.3 22 .9 19 .3 18 .4 23 .3 22 .5 18 .8 18 .3 20 .1 16 .0 18 .0 20 .0 3 .6 19 .3 20 .5 20 .9 20 .4 22 .8 22 .4 24 .1 19 .2 20 .4 23 .5 21 .8 19 .7 20 .4 19 .1 18 .2 17 .2 21 .8 20 .6 18 .1 20 .4 22 .2 21 .6 23 .6 22 .6 23 .0 18 .4 21 .8 24 .5 23 .2 19 .6 20 .7 19 .1 18 .6 19 .8 23 .2 23 .7 19 .2 22 .4 21 .5 21 .0 25 .3 24 .0 24.6 19.6 21.3 26.2 22.6 21.5 22.0 20.8 18.1 18.8 23.6 24.2 18.9 24.2 23.3 20.7 27.9 24.4 1178 H-24616: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fi FEMALE RATS GROUP: VI-1 DOSE: 250 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644842 644843 644844 644845 644846 644847 644848 644849 644850 644851 644852 644853 1-8 8-15 15-22 22-29 29-36 36-43 12.3 12.2 13.2 12.8 12.0 13.1 12.7 13.4 15.1 14.0 13.7 11.8 19.5 18.0 18.6 17.9 17.0 19.0 18.5 16.8 21.3 20.5 20.2 17.7 21.8 21.3 20.3 20.7 19.5 22.1 21.2 19.0 22.7 20.8 23.1 19.1 18.9 22.0 21.1 21.8 19.6 22.3 21.8 20.6 24.4 20.3 24.4 18.2 18.8 21.2 20.6 20.7 19.7 23.9 23.9 20.4 29.6 21.4 23.4 17.3 17.3 24.0 22.2 21.7 20.6 25.3 25.5 22.8 28.9 21.9 23.9 17.5 1179 Company Sanitized. Does 1 H-24616: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fi FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644889 644890 644891 644892 644893 644894 644895 644896 644897 644898 644899 644900 644901 644902 644903 644904 644905 644906 1-8 12 .5 13 .5 13 .0 12 .1 12 .2 12 .4 11 .8 11 .6 13 .1 14 .0 11 .7 14 .0 14 .1 11 .8 13 .2 13 .5 12 .0 11 .9 8-15 15-22 22-29 29-36 36-43 18.0 18.2 17.9 16.6 17.9 16.2 17.0 19.5 17.5 20.1 17.7 20.1 19.4 17.6 17.0 18.2 17.9 17.4 19 .5 18 .8 20 .7 18 .1 18 .9 17 .3 19 .5 23 .9 20 .2 19 .9 19 .8 23 .2 21 .6 18 .6 20 .7 19 .4 20 .8 18 .1 21 .0 18 .8 22 .5 18 .3 19 .6 18 .2 21 .1 19 .5 22 .4 20 .9 21 .9 23 .4 21 .7 19 .9 9 .7 19 .3 24 ,0 17 .8 22.9 18.2 23.2 19.8 19.2 17.8 23.1 24.9 23.0 20.9 21.6 24.4 25.2 19.5 21.2 20.6 23.7 19.5 23 .1 16 .3 22 .2 18 .8 18 .4 18 .3 20 .3 24 .3 22 .8 21 .8 21 .3 24 .1 23 .8 20 .2 21 .2 19 .7 24 .1 18 .9 1180 Company Sanitized. Does not contain TSCAr'"?.'1 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 APPENDIX JJ REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL CLINICAL OBSERVATIONS: Fi GENERATION 1181 Company Sanitized. Does not contain TSCA CB8 H-24616: Subchroiuc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________DuPont-4739 REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL CLINICAL OBSERVATIONS: Fi GENERATION EXPLANATORY NOTES Notes Day of weaning = Test Day 1. 1182 Company Sanitized. Does not contain TSCA CBJ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY AMIMAL NUMBER 644438 644439 644440 644441 644442 OBSERVATION / PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 644443 644444 644445 644446 644447 644448 644449 644450 HEAD CAUGHT IN CAGE AS CLOSING DOOR8 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 FIRST DAY OBSERVED LAST DAY OBSERVED 30 30 28 28 29 29 30 30 25 25 15 15 29 29 33 33 31 31 27 27 27 27 30 30 28 28 30 30 a This clinical observation is not reported in the Summary Data Tables. 1183 Company Sanitized. Does rsotconiam TSCA r-p? H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL NUMBER INDIVIDUAL CLINICAL OBSERVATIONS IN Fi MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 644451 644452 644453 644454 644455 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 28 28 28 28 27 27 31 31 28 28 1184 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL NUMBER INDIVIDUAL CLINICAL OBSERVATIONS IN Fi MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 644508 644509 644510 644511 644512 644513 644514 644515 644516 644517 644518 644519 644520 644521 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 28 28 28 28 27 27 38 38 26 26 28 28 28 28 26 26 27 27 29 29 29 29 28 28 30 30 27 27 1185 a. Does not contain TSCACB^ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 ANIMAL NUMBER INDIVIDUAL CLINICAL OBSERVATIONS IN Fi MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 644522 644523 644524 644525 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 30 30 28 28 32 32 30 30 1186 Gwspssy Sanitized. Does not contain TSCA CBt H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL NUMBER INDIVIDUAL CLINICAL OBSERVATIONS IN Fi MALE RATS GROUP: V-l DOSE: 250 MG/KG/DAY OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 644577 644578 644579 644580 644581 644582 644583 644584 644585 644586 644587 644588 PREPUTIAL SEPARATION INCOMPLE1?E SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 43 43 28 28 28 28 28 28 39 39 28 28 27 27 28 28 29 29 27 27 27 27 29 29 1187 Company Sanitized. Does not contain TSCA' H-24616: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL NUMBER INDIVIDUAL CLINICAL OBSERVATIONS IN Pi MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 644625 644626 644627 644628 644629 644630 644631 644632 644633 644634 644635 644636 644637 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 CORHEAL OPACITY LEFT EYE(S) PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 27 27 30 30 29 29 31 31 29 29 28 28 32 32 29 29 30 30 30 30 1 43 28 28 27 27 33 33 1188 .OffipanySaniteed. Does roe contain TSCA CR< H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________DuPont-4739 ANIMAL NUMBER INDIVIDUAL CLINICAL OBSERVATIONS IN Fi MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 644638 644639 644640 644641 644642 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 27 27 26 26 27 27 28 28 28 28 1189 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL NUMBER INDIVIDUAL CLINICAL OBSERVATIONS IN Fi FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 644698 644699 644700 644701 644702 644703 644704 644705 644706 644707 644708 644709 644710 644711 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 20 20 10 10 14 14 11 11 10 10 10 10 11 11 11 11 13 13 13 13 11 11 20 20 12 12 10 10 1190 Company Sanitized. Does no6 contain TSCA CB1 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL NUMBER INDIVIDUAL CLINICAL OBSERVATIONS IN Fi FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 644712 644713 644714 644715 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 11 11 11 11 15 15 1191 Company Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL NUMBER INDIVIDUAL CLINICAL OBSERVATIONS IM Fi FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 644770 644771 644772 644773 644774 644775 644776 644777 644778 644779 644780 644781 644782 644783 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 11 11 10 10 17 17 15 15 20 20 13 13 13 13 13 13 15 15 11 11 13 13 19 19 15 15 18 18 1192 Company Sanitized. Does not contain TSCA CB! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL NUMBER INDIVIDUAL CLINICAL OBSERVATIONS IN Fi FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 644784 644785 644786 644787 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 21 21 18 18 10 10 10 10 1193 S. Does not eorg3a?n rsCA H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS GROUP: VI~1 DOSE: 250 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 644842 644843 644844 644845 644846 644847 644848 644849 644850 644851 644852 644853 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 11 11 13 13 13 13 13 13 17 17 13 13 21 21 14 14 21 21 10 10 17 17 11 11 1194 Company Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study m Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL NUMBER INDIVIDUAL CLINICAL OBSERVATIONS IN FI FEMALE RATS GROUP: VIII-l DOSE: 1000 MG/KG/DAY OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 644889 644890 644891 644892 644893 644894 644895 644896 644897 644898 644899 644900 644901 644902 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 13 13 12 12 16 16 13 13 13 13 20 20 12 12 13 13 12 12 15 15 11 11 15 15 10 10 1195 Company Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations __ _ ___DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi FEMALE BATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 644903 644904 644905 644906 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 16 16 11 11 11 11 11 11 1196 Company Sanitized. Does not contain TOC.^ ^