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kZtb-f& l'J PERSONAL AND CONFIDENTIAL CC: J. H. Todd G. T. Rosen 1und J. M. Cordrey W. T. Darnell J. F. Doughty D. 'A. E rdman T. A. Foster Dr . Y . L. Power T. L. Schrenk R. N. T aylor P. Thi stleton & J . Zipfel July 14, 1982 TO: FROM: R. J. BURGER J. G. L O S C H IAVO TRENDS IN BLOOD C-8 LEVELS FOR VARIOUS T E FL ON EMPLOYEE GROUPS SUMMARY Comparison of data for sample results obtained up to October, 1981 with corresponding data up to June, 1982 shows; For 40 FEP Operators, blood C-8 levels decreased an average 23%. For 85 Fine Powder and Granular Operators, blood C-8 levels decreased an average 18%. New TEFLON employees are accumulating C-8 at a lower rate than in previ ous years. Fine Powder Zone 6 Operators still have the highest blood C-8 levels. Blood C-8 levels in females transferred out of T E FL ON are continuing to decrease. 0835W-1 000199 EID079049 RJZ009070 2 DISCUSSION The attached Tables contain C-8 in blood data for various employee groups in the TE FL ON Divisions. Blood C-8 data were obtained from the FLAIR program. The FLAIR program has proven itself as a valuable tool in aiding in the analysis of blood C-8 data. All blood samples were analyzed by the C-8 specific method. Data recorded in FLAIR by 6/24/82 are used in this summary. Comparisons are made between the data recorded in FLAIR up to October, 1981 with corresponding data up to June, 1982. The following observations are made: FP Operators are ex pe ri en ci ng an overall drop in blood C-B levels of 23%. The decrease for those Operators with over 700 days of service is statistically significant at the 0.05 level using the paired t-test. Fine Powder Operators are ex pe ri en ci ng an overall drop in blood C-8 levels of 12%. Granular Operators are experiencing a drop of 22%. The decreases for Operators with over 700 days of service is not yet statistically significant. Blood C-8 levels in new T E F L O N employees (those with less than 700 days of service) are increasing. However, their levels are increasing at a slower rate than they were in previous years. The average rate of increase for TEFLON Fine Powder Zone 4 Operators using data collected up to October, 1981 was 0.0019 ppm/day. Using only 1982 data, the average rate of increase has dropped to 0.0004 ppm/day. Fine Powder Zone 6 Operators continue to have the highest blood C-8 levels. They average 8 ppm and range as high as 26 ppm. TEFLON Zone 6 Operators have higher blood C-8 levels than T E F L O N Zone 4 Operators. This is because C-8 accumulates in the body over time. Zone 6 Operators have worked in TE FLON much longer than Zone 4 Operators. Operators from four other Divisions at Washington Works have very low but measurable quantities of C-8 in their blood. Blood C-8 levels in females tr ansferred out of TE F L O N dropped an average 19% over an average 161-day period. This includes only females with 0.1 ppm or more C-8 in their blood. The rate of C-8 elimination in females with less than 0.1 ppm is very slow. It is essentially zero for this group. RJZ009071 0835W-2 000200 EID079050 3 CONCLUSION The diligent efforts on the part of T E F L O N Production and Technical to reduce C-8 air levels are paying off. Significant decreases in employee blood C-8 levels are now being seen. Efforts must be continued in the TE FL ON Divisions to control C-8. Both air and blood sampling programs should continue at their present rates. It is important to prevent overconfidence which could lead to overlooking items and thus minimizing effectiveness of current programs. Attachments JGL/nsw 0835.W- 3 RJZ009072 000201 EID079051 AGE AT LATEST BLOOD Ttsr 33 42 26 27 33 24 35 27 32 28 35 26 30 oo 25 38 o 28 *0 EID079052 27 22 25 , 24 33 IABLE 1 BLOOD C-8 LEVELS IN FEMALcS TRANSFERRED OUT OF TEFLON A. FEMALES WITH BLOOD C-8 LEVELS AT OR ABOVE 0.1 ppm C-8 LEVEL WHEN LEAVING TEFLON (ppm) C-8 LEVEL AFTER LEAVING TEFLON (ppm) NO. OF DAYS SINCE LEAVING TEFLON 0.14 1.9 1.0 0.57 1.3 0.11 0.10 2.4 0.83 0.11 0.14 5.1 0.19 0.13 4.5 2.5 0.086 1.2 0.65 0.39 0.98 0.086 0.080 2.0 0.70 0.093 0.12 4.4 0.17 0.12 4.2 2.6 143 288 282 140 114 107 178 126 113 106 303 112 176 161 125 108 AVERAGE = 161 % CHANGE IN CLEVELS - 38.6 - 36.8 - 35.0 - 31.6 - 24.6 - 21.8 - 20.0 - 16.7 - 15.7 - 15.5 - 14.3 - 13.7 - 10.5 - 7.7 - 6.7 + 4.0* - 19.1 + B. 0.078 0.061 0.045 0.092 0.019 FEMALES WITH BLOOD C-8 LEVELS BELOW 0.1 ppm 0.067 0.053 0.041 0.092 0.019 321 107 96 106 296 AVERAGE * 185 - 14.1 - 13.1 - 8.9 0.0 0.0 - 7.2 + 6.1 * This is probably due to analytical error. JGL/nsw 7/13/82 0835W-4 ao60ozra TABLE 2 SUMMARY OF WASHINGTON WORKS EMPLOYEES' C-8 IN BLOOD LEVELS "____________ GROUP_________________ NO. OF SAMPLES RANGE (ppm)* AVERAGE (ppm) Fine Powder/Dispersion Zone 6 Operators FEP Zone 6 Operators Granular Zone 6 Operators Fine Powder/Dispersion Zone 4 Operators TEFLON Polymers Production Foremen TEFLON Monomer Operators Granular Zone 4 Operators Laboratory** TEFLON Copolymers Production Foremen TEFZEL/Telomer "A" Operators FEP Zone 4 Operators Mechani cs Research (Engineers & Chemists) TEFLON Polymers Technical TEFLON Polymers Maintenance Supervision TEFLON Copolymers Maintenance Supervision TEFLON Copolymers Technical LUCITE Zone 4 Operators DELRIN Zone 6 Operators Filaments Zone 4 Operators ZYTEL Zone 6 Operators 21 15 10 37 23 31 17 67 19 26 25 98 8 29 15 2 16 4 2 3 2 1.3 - 26.0 0.3 - 9.6 0.2 - 9.1 0.02 - 6.9 0.1 - 2.8 0.2 - 6.5 0.01 - 4.3 0.01 - 3.2 0.03 - 2.1 0.02 0.01 - 1.6 0.04 - 1.6 0.09 - 0.6 0.03 - 0.6 0.06 - 0.4 N.D.***- 0.5 0.02 - 0.2 0.02 - 0.1 N.D. - 0.09 0.02 - 0.04 0*--0* 8.0 3.0 2.7 1.9 1.2 1.1 0.6 0.6 0.5 0.5 0.5 0.4 0.3 0.2 0.2 0.2 0.1 '0.08 0.07 0.05 0.03 RJZ009074 * Only ttie most current blood C-8 sample result for each employee was used to determine ranges and averages. ** The Laboratory group includes Trainees Senior Laboratorians, tab Analysts, Research Analysts, and Lab Supervision *** N.D. = None Detected (< 0.007 ppm). JGL/nsw 7/13/82 083SW-S 000203 E1D079053 TABLE 3 TRENDS IN BLOOD C-8 AVERAGES FOR TEFLON ZONE 4 AND ZONE 6 OPERATING GROUPS \ GROUP Fine Powder - Zone 6 FEP - Zone 6 Granular - Zone 6 Fine Powder - Zone 4 Granular - Zone 4 FEP - Zone 4 AVG. C-8 LEVEL USING DATA RECORDED IN FLAIR BY 10/19/81 (ppm) 9.8 4.4 3.3 2.0 0.8 0.6 NO. OF SAMPLES 16 10 9 16 14 10 AVG. C-8 LEVEL USING DATA RECORDED IN FLAIR BY 6/24/82 (ppm) 3.0 2.1 1.9 0.6 0.5 NO. OF SAMPLES 21 15 10 37 17 25 % CHANGE IN C-8 LEVELS -18 -32 -18 -5 -25 -17 oCO 000204 UGL/nsw 7/13/82 0835W-6 s ao-voV4/JO^l ^ooozry 000205 REFERENCE NUMBER JGL/n sw 7/13/82 0835W-7 T '.E 4 TEFLON FINE POWDER SERVICE OPERATORS - ZONE 4 DATE OF FIRST SAMPLE C-8 IN BLOOD (ppm) DAYS IN JOB AT SAMPLE DATE DATE OF SECOND SAMPLE 4/27/81 0.420 0 10/14/81 4/14/81 1.100 317 9/10/81 4/27/81 0.031 2 7/1/81 8/25/81 0.610 121 1/13/82 7/24/81 0.760 73 2/3/82 4/7/81 3.600 462 3/11/82 10/7/81 0.039 3 12/18/81 8/28/81 0.300 124 1/14/82 10/7/81 0.007 3 12/4/81 8/24/81 1.500 601 2/9/82 4/8/81 3.500 738 8/19/81 8/28/81 0.650 124 12/9/81 10/14/81 0.740 531 2/3/82 8/31/81 1.700 1,065 1/19/82 . 4/6/81 4.300 461 8/26/81 5/4/81 b/7/81 3.900 4.800 , 1,310 725 9Z0600ZHI m 3/11/82 o-VoUV/JOi1 12/30/81 C-8 IN BLOOD (ppm) 1.400 1.500 0.200 0.920 1.100 3.900 0.099 0.350 0.021 1.500 3.500 0.640 0.700 1.600 4.000 2.600 3.600 DAYS IN JOB AT SAMPLE DATE 170 466 67 262 267 800 75 263 ,61 770 871 227 643 , 1,206 603 1,621 962 \ WORKED OTHER TEFLON JOB(S) BEFORE THIS JOB (YES/NO) AVG. DAILY RATE OF C-8 DECREASE OR INCREASE (ppm/Day) YES + 0.0058 NO + 0.0027 NO + 0.0026 NO + 0.0022 YES + 0.0018 NO + 0.0009 NO + 0.0008 YES + 0.0004 NO + 0.0002 NO 0.0000 NO 0.0000 YES - 0.0001 NO - 0.0004 NO - 0.0007 NO - 0.0021 NO - 0.0042 NO - 0.0051 REFERENCE NUMBER DATE OF FIRST SAMPLE 8/20/80 4/6/81 8/18/80 7/6/81 ih BLE 5 TEFLON TFE PROCESS OPERATORS - FINE POWDER * ZONE 6 C-8 IN BLOOD (ppm) 24.000 4.300 29.000 32.000 DAYS IN JOB AT SAMPLE DATE 8,846 857 9,726 2,105 DATE OF SECOND SAMPLE 1/14/82 9/1/81 3/19/82 2/18/82 C-8 IN BLOOD (ppm) 26.000 4.400 20.000 24.000 DAYS IN JOB AT SAMPLE DATE 9,358 1,005 10,314 2,332 l WORKED OTHER TEFLON JOB(S) BEFORE THIS JOB (YES/NO) AVG. DAILY RATE OF C-8 DECREASE OR INCREASE (ppm/Day) NO + 0.0039 NO + 0.0007 NO - 0.0153 NO - 0.0352 00020G JGL/n sw 7/13/82 835W-8 4/2y/81 9/22/81 10/7/81 10/13/81 10/13/81 4/21/81 4/30/81 4/7/81 0600201 TABLE 6 TEFLON COPOLYMERS FEP SERVICE OPERATORS - ZONE 4 0.009 0.100 0.021 0.013 0.039 1.250 0.760 1.700 1 295 3 2 2 732 115 827 9/10/81 4/7/82 2/5/82 3/25/82 1/14/82 10/9/81 9/28/81 8/18/81 0.150 0.230 0.053 0.052 0.051 1.200 0.660 1.600 135 492 124 165 95 903 266 960 a o-j VO'*OJ \ CTv .... NO + 0.0011 NO + 0.0007 NO + 0.0003 NO + 0.0002 NO + 0.0001 NO - 0.0003 NO - 0.0007 NO - 0.0008 REFERENCE NUMBER O O ' \ DATE OF FIRST SAMPLE 8/29/80 8/29/80 8/19/80 8/29/80 4/1/81 8/26/80 8/26/80 8/20/81 8/27/81 TABLE 7 TEFLON COPOLYMERS POLYKETTLE FEP OPERATORS - ZONE 6 C-8 IN BLOOD (ppm) 4.000 1.900 7.800 1.500 1.300 6.600 5.500 13.000 5.800 DAYS IN JOB AT SAMPLE DATE 6,846 8,733 7,729 7,760 5,449 7,757 9,112 7,940 9,279 DATE OF SECOND SAMPLE 10/14/81 1/27/82 9/25/81 8/13/81 3/31/82 8/7/81 8/5/81 7/17/81 2/2/82 C-8 DAYS IN IN BLOOD JOB AT (PPm) . SAMPLE DATE 4.500 7,257 1.800 9,249 7.500 8,131 1.200 8,109 0.950 5,813 5.300 8,103 4.200 9,456 9.600 8,271 3.100 9,438 WORKED OTHER TEFLON J0B(S) BEFORE THIS JOB (YES/NO) NO NO YES NO YES NO NO YES NO AVG. DAILY RATE OF C-8 DECREASE OR INCREASE (ppm/Da.y) + 0.0012 - 0.0002 - 0.0007 - 0.0009 - 0.0010 - 0.0038 - 0.0038 - 0.0103 - 0.0170 JGL/n sw 7/13/82 0835W-9 o'O 8Z0600ZTH