Document baz0MvNVgaew5gVBm4z7jGZNy

OFFICIAL FILE COPY *LC AurMl Sr. teand Boohafa Tala Onivarwity School of Madicin* Long A--arch Oaatar 333 Owlar at. Saw Bmo, Prana. 06510 It Jmm 1974 Dau Doctor Bouhoya t Z would ba plaaaad to visit with yon on 1 July 1974 as wa diacnaaad on th telephone the other day. I will ba arriving. by train and Vtid ba there at abont 11:00 A.X. I look forward to seating with yaw aad dtacueelnf tha aabaatoala tody. Slaearaly yours. HAStjd a.A. Sinclairs, x.D. Medical Dlractor a. MJ rf f.-t x-^ojui ?*- T/ rAitk J'(oJt islt' <2> <*T / <rf f0 cSC^d `TJ^sk /W 05710 447480 * jj INTEROFFICE CORRESPONDENCE Mr. P.C. Krist~v\ date 14 June 1974 DECEIVED JUN i 7 1974 P. C. K. Five Refinery Study of Asbestosis I have been trying to interest Cornell University in supervising this study on asbestosis without results, so 1 wrote to Dr. A. Bouhuys at the Yale University Lung Researcn Center. Attached is a copy of his reply. He has invited me to go visit the school and his laboratory to discuss the project before he submitk a formal protocol. I would like to do this on 1 July, if it meets\with your approval. *>5711 447481 cu: ;ity .Vci /-/ft ii. C'l'-'iui 'iri/t 06510 SCHOOL Q[: MEDICINE j j j Ccd.tr S: rent une 5, 1974 YALE UNIVERSITY LUNG RESEARCH CENTER AREND OOUHUVS, Director '' . H.A. Sinclaire dical Director oil Oil Corporation ' East 42nd Street York, New York 10017 $ ?*v:"/ r Dr. Sinclaire: ifc you for your letter of May 30, 1974. I would be very interested in doing : study for your company as veil as for the other oil companies involved in project. respect' to the protocol, our experience has been with medical histories -listered by trained interviewers (not physicians). I have looked into lossibility of self-administered interview questionnaires and have talked a number o people about then. The general experience seems to be that sonably complete history often takes at least 45 minutes or an hour if seif-adminji stered: in contrast, our infwiowpr adm-f5teredquestionr.sire only 10 to 20 minutes depending on the number of symptoms reported. 'er whether a complete physical examination is required. We feel that tation for `.vasal rales is a very important component of a search for osis but, unless there are other compelling reasons to do a complete I feel that a more general physical examination can be omitted. spect to the lung function test, we derive values for vital capacity, as well as additional measurements of maximum flow rates, from a flowcurve recorded with electronic equipment. We have a system that can do -line and which provides a complete report for immediate review as well iter compatible tape for processing: of'group data. We feel that the iuch a system is preferable over the use of the Pulmonor. I would furommend that measurement of single breath diffusing capacity be included persons with an abnormal chest X-ray and/or vital`capacity less than 80% redicted value. I quite agree with your recommendations for X-ray review 1 further recommend that- the UICC Cincinnati classification be used in nces to objectivate the reporting as much as possible. certainly important to include control subjects from refinery offices cr groups. We will also have available control data from community is in three different towns in the U.S., which allow us to determine ues for rural and urban dwellers, blacks and whites, males and females, smokers and non-smokers. Thus, we would be able to make a sophist!- ment as to whether each particular individual's loss of lung function I S.n ri ot > :ing stos 3tOS rkersfeel rther This stup ficult _- .\u plans P would your t leave? ipidemioi