Document barrOJwb6jNZKLJwg8YY7Lvyk

* --a A A, The Cosmetic, Toiletry and Fragrance Association, Inc. 1133 15th STREET, N.W., WASHINGTON, D.C. 20005 202/331-1770 - TELEX 89-2673 .- * James H. Merrill P re s id e n ! Norman F. Estrin, Ph.D, Vico Pre$id#nt-- Science M I N.U T E S CTFA TALC SUBCOMMITTEE A meeting of. the CTFA Talc Subcommittee was held on July 8th, 1976 at the Chemists' Club in New York City. Those in attendance were: George Sandland, Bristol-Myers Company (Chairman) Tryggve Baak ` John Hilovsky, Mennen Company (for Robert Suffis) Ray Kr amines, Whittaker, Clark & Daniels George Lee, Johnson & Johnson Baby Products Company Louis Murino, Cyprus Industrial Fred Roesch, Whittaker, Clark &-Daniels Robert Rolle, Johnson & Johnson Baby Products company -Joseph Simko, Colgate-Palmolive Terry Smith, Faberge, Inc. Compan{ y/ - f - J^S&v Ian Stewart, Walter C. McCrone ' C.S. Thompson, R.T. Vanderbilt- : John Travers, Avon Products, Inc.- Norman F. Estrin, CTFA - / 1 Those absent from this meeting were: Murray Berdick, Chesebrough-Pond's Inc. George Cohen, Bristol-Myers .Company Christopher Costello, Colgate-Palmolive Compari^ Allan Harvey, R.T. Vanderbilt Roderick Mundy, Sterling Drug Company DeWitt Petterson, Johnson & Johnson Baby Products Company John Schelh, Johnson & Johnson Baby Products Company Harold Stanley, Charles Pfizer Robert Suffis, Mennen Company Ronald Yakupcin, Kolmar Laboratories, Inc. Mr. Sandland opened the meeting by distributing a draft of a talc standard prepared.by the Toiletry Preparation Federation and briefed the- Subcommittee on the March 31st, 1976 minutes. 1. Talc Standard The problem in developing a definition of `cosmetic talc con sistent with available safety data wgs the major subject of discussion. The following definition was proposed and adopted * EXHIBIT WCD-391 ` Goodhue WCD 000158 unanimously for inclusion in the CTFA Standard. "Cosmetic talc is an essentially white odor- . less, fine powder ground from naturally oc curring rock ore. It consists typically of . 90% hydrated magnesium aluminum- silicate, having,the ideal formula Mg6 [SigO20J '(h)4 / . with the remainder being naturally associated - minerals such as calcite, chlorite, dolomite, kaolin and magnesite and containing no de tectable asbestos minerals." i2. Animal Studies ' !' - The ultimate importance of the Industry engaging in additional animal, studies, on representative cosmetic talcs was discussed in detail with the Talc. Subcommittee. It was noted that, at the March 31st, 1976 meeting, .it was agreed that Dr, Gressel and Dr. Finkel'stein would coordinate activities in this re gard. (NOTE: The Antiperspirant Task Force is coordinating with a subcommittee of the CTFA Pharmacology & Toxicology Committee to prepare a protocol for a 30-day study which would be the first step towards possible long-term studies. One of the materials that would b.e tested is -an aerosolized talc. The protocol will be sent out for bid within the next few weeks.} Dr. Estrin was asked to investigate how long-term testing of talcs could be financed. Fred Roesch-and George Sandland were asked to prepare a proposal for what composites would-be representative of cosmetic talcs used. That infor mation should be sent to Dr. Estrin for distribution to the Subcommittee' by August 1st. 3. Mt; Sinai Paper Dr.. Estrin noted plans by the Mt. Sinai group to publish an extensive paper on cosmetic talc analysis and CTFA's response previously distributed to the Talc Subcommittee. *' 4 Mt. Sinai Visit It was agreed that CTFA should establish dialogue with the Mt. Sinai group. . A meeting prior to the meeting'with the Mt. Sinai group was agreed upon as .necessary in order to discuss the agenda. Tentative participants in Such a.visit include Tryggve Baak, Bob Rolle, Terry .Smith, Ian Stewart, Dr. Estrin, and possibly someone from FDA. 5. Miscellaneous Panel Presentation Dr. Lee reported on the considerations of the Miscellaneous External Drug Panel. He stated that Johnson & Johnson has provided a transcript of its presentation to the Antiper spirant Panel. The review by the,Miscellaneous External Drug Goodhue WCD 000159 Panel has not been completed and the Panel is presently awaiting a summary1. 6. Nomenclature ' . The Talc Subcommittee is hot, at the present time, consider * ing a request to the CTFA Cosmetic Ingredient.Nomenclature Committee for a change in nomenclature from "Talc" to "Cos metic Talc". , The next Meeting of the CTFA Talc Subcommittee is scheduled for September 9thr 1976 at the Chemists' Club in New York City at 10:30 cl *Ift* There being no further business,, the meeting adjourned. Norman F. Estrin, Ph.D. Vice President - Science July 12th, 1976 NFE: jj. I i \ "i Goodhue WCD 000160