Document bakqp29pzvNgBXqdjLaQ0bbEk

: AR226 _ 1161 cmomgmise SEE, Rl1oo9st)ei5A5ro.7.nB00uc3o0mrr TAFT, STETTINIUS & HOLLISTER LLP 1800 FIRSTAR TOWER 425 WALNUT STREET CINCINNATI, OHIO 45202-3957 FA3X135.318313.8210002808 oonato am April 12,2002 comme ii iesn in n co5 ms soS uoco erce eCor - CERMATLLNI O. 7F 0001I 6700E009D 4961 7412 RETURN RECEIPT REQUESTED IRIS Submission Desk clo ASRC 6Gr3e0e1nbIevlyt,LaMneD, S2u0i7te70300 < on z= 3S3R =E B2a9 = 5 Re: IRIS Submission Inventory for Perfluorooctanoic A-cAmi mond ium Salt IRIS Submission Desk: EnvironOmnenJtaanluParroyte9,ct2i0o0n2A,agennoctyicweaasppseolairceidtiinng tahdediFteidonearlalinRfeogrimsatteirotnhawtitthhereUsnpietcetdtoStaatnes euxppcoosmuiren,gi[nRaIdSdietviaolnutaoticohnrooftnihceexrepfoesruernec.e"d Aclhtehmiocuaglh "UfSorEePffAecrtesqfuersotmedaciuntiteiaalnsdusbumbicshsrioonnic niontviecnetotrhyati"ntfhoermpautbiloinc mbyayMasrucbhmi1t1,in2f0o0r2m,atUiSonEoPnAasntyatcehdeimnictaslJsaunbusatraync9,e2a0t0a2n,yFteidmeer.a"l(R6e7giFsetde.r Reg. 1214 (Jan. 9, 2002).) dofe hNuemmao`nuThrdesruiannnkddienrCgsoiwmganpteaedrniyssuc(plp"alDsiusePscoonwutin"ts)helainmfWomreotsnhtiosVueimrwgphienorifahluaSotvraeotaeoscCstoeaurntroetadtrecil(saaii/nmkg/safa"rgCao-im8n"sc)to.nEtIIanmidnuaPtoinotn connection with that litigation, the undersigned has received, among other things, copiesofthe documents relating to thehealthand environmental effectsofC-8 referenced on the attached plirsotst.ecIttioisn pwoistshibrleesptehcatt tDousPomoenooftrtthhee 3reMfeCreonmcpedandyocummaeyntcsl.aim confidential business information 000005 LE 1755 IRIS Submission Desk April 12,2002 Page2 referencPeldeaasbeocvoentfoarctanthyequunedsetrisoinsgnreedgaardtihnegaadndyreosfst,hteelienpfhoornmeatniuomnbererf,earenndceed-moanilthaedsderelsissts, Thank you. RAB/mdm Attachments: I. 2. 3. 4. Th Robert A. Bilott C-8 Human Health Risk Evaluations; CC--88 AHnuimmaaln/THoexailctiht/yEpSituddeimeiso;laongdy Studies; C-8 Environmental ImpactDistribution Studies. 000008 LE 1756  C-8ANIMAL/TOXICITY STUDIES 1961 * * DuPont, Intemal Memo Re Toxicityof Teflon Dispersing Agents (11/9/61) DuPont Haskell Lab, Acute Oral ToxicityofC-8-APFC/FC-143 Rats (11/8/61) 1962 + DDuoPgosnta,ndSRuamtmsa(r1y9o62f)Toxicity Studies on Fluorocarbon Dispersing Agents in * (DFuCP-o1n4t3,)PianthMoagleeniCcRACctDionRaFtosl(l2o/w9i/n6g2R)epeatedOralAdministration of C3APFC "DuP(oFnC-t14,3)PianthMoagleeniCcRACctDioRnatFsol(l2o/w14i/n6g2)Single Oral Administration of CSAPEC 1965 DuPont, Effect (8/19/65) of Fluorocarbon Dispersing Agents on the LiversofRats and Dogs . C`lEalyoutsoinn,eW(.PJh.a,rmTahceoMloagmymaofliFlaunoTroidxeisc,ol(ForgaynokfA.OrSgmaintihc, CEod.m)p(o1u9n6d6s)Containing 1966 "DuPSocinetnc,esMCoenmcoerRnei:ngBiTooaxsicsiatyyRoefsCu-lts afnrdomTrtihteoPnhDiilsacdhelaprhgieasAtcoaOdheimoyRiovfeNraural (10/18/66) 1968 * + 1976 " * * 1971 DuPont, Haskell Lab, Acute Oral Test of APFO in Male CHRCD Rats (6/13/68) DuPont, Haskell Lab. Acute Inhalation Dust Toxicityof APFO in Rats (6/17/68) Biosearch, Inc., Primary Eye Irritation Study - Rabbits (for 3M) (3/4/76) Biosearch, Inc., Primary Skin Imitation Study - Rabbits (for 3M) (3/4/76) Biosearch, inc. Acute oral Toxicity - Rats (for 3M) (3/4/76) Bionetics/Litton., Ames SalmonellMicrosome Assay (for 3M) (12/20/77) 000007 LE 1757 1978 + + . + 1979 + . . + . + 1980 + + . . . + 3MEnv. Lab, IRDC 137-088; FM-3422/Monkey Tests (8/16/78) E.G. &G. Bionomics, Summary of Histopathological Examinations of Fathead Minnow Exposed to 78:03 (FC-143) for 30 days (for 3M) (9/78) Int'l Res. & Devel. Corp., 90-Day Subacute Rat Toxicity Study; Fluorad FC-143 (for 3M) (11/6/78) IntlRes. & Devel. Corp., 90-Day Subacute Rhesus Monkey Toxicity Study; Fluorad FC-143 (For 3M) (11/10/78) Scheider, P.W., DuPont Haskell Lab. Memo Re: 3M's Fluorad Fluorochemical FC-143 Toxicity Studies (3/5/79) Steiner, C.E., DuPont Memo Re: C-8 Communications Meeting - Outline, Talk & Charts (7/31/80) DuPont Haskell Lab., Inhalation Subacute: APFO (Albino Male Rats) (7/20/79) DuPont Haskell Lab., Skin Irritation Test on Rabbits: FC-143 (10/5/79) DuPont Haskell Lab., Eye Irritation Test in Rabbits: FC-143 (10/5/79) DuPont Haskell Lab., Skin Absorption LDS0-Rabbit and Rat: FC-143 (10/26/79) Ophaug, RH. and Singer, L., MetabolicHandlingofPFOAinRats, 163 Proceedingsof Soc. for Exp. Biol. Medic. 19-23 (1980) Griffith, F.D. and Long, J.E., AnimalToxicityStudieswithAPFQ, 41 Am. Ind. Hyg. Assoc. J. 576-583 (1980) Riker Lab., Absorptionof FC-143 in Rats After A Single Oral Dose (for 3M) (1/17/80) 3M Env. Lab., Aquatic Toxicity Testing: FC-143 (Fathead Minnows) (5/8/80) DuPont Haskell Lab., Skin Absorption LD50-Female Rats: FC-143 (9/22/80) DuPont Haskell Lab., Rat Skin Absorption Subacute Study With FC-143 (Male CHR-CD Rats) (10/10/80) 000008 -2- LE 1758 1981 + + + + + + + + + + + + + + + + 3MEnv. Lab, Daphnid Bioassay: CS-2151 (2/5/81) 3MEnv, Lab, Oral Rangefinder Studyof T-2998COC (APFO) in Pregnant Rats (3/12/81) CUyntiovt.oxoifcMiitnyinn. C(E3nHv P1a0tTho1l/o2gyClLoanba)l,CAenllALsisnaeyofofr CtehlelTeTsrtanCshfeomrimcaatiloTn-a2n9d42 COC (for 3M) (3/4/81) DuPont, Haskell Lab., Subacute Inhalation ToxicityofPentadecafluorooctonoic `Acid, Ammonium Salt in Rats (4/15/81) DuPont, Haskell Lab., Oral LDSO Test in Guinea Pigs (6/1/81) DuPont, Haskell Lab., Oral LDSO Test in Rats (6/1/81) DuPont, Haskell Lab., Oral LDSO Test in Mice (6/17/81) 3MEnv. Lab, Acute Effect ofCS-2151 on Microbial Respiration (8/24/81) DuPont, Haskell Lab., Oral Acute Toxicity Comparison Test in Rats (9/29/81) DuPont, Haskell Lab., Oral LDS0 Test in Rats (9/30/81) DuPont, Haskell Lab, Liver Weight Comparison in Castrated and Ovariectomized Rats vs. Normal Rats (10/7/81) DuPont, Haskell Lab., Mouse Feeding Study - 14 Day (10/26/81) DuPont, Haskell Lab., APFO Blood Levels in the Female Rat (12/7/81) 3M Company, Oral Teratology StudyofT-2998COC (C8/FC-143) in Rats (as amended 12/15/81) DuPont, Haskell Lab., The Effects of Dowex lon Exchange Resin on the Toxicity. ofC-8 in Rats (12/31/81) 3M Env. Lab., Multi-Phase Exposure/Recovery Algal Assay Test Method (FC143) (11/16/81) 000009 .3. LE 1759 1982 + + + + + + + + + + + + + + 1983 + Kennedy, G.L., DuPont Interim Report: Acute ToxicityofPerfluorocarboxylic Acids (1/11/82) Kennedy, G.L., DuPont Interim Report: Evaluationof Sex/Species Differences in Response to C-8 (1/11/82) DuPont Haskell Lab., C-8 Gavage: Embryo-Fetal Toxicity and Teratogenicity Studyinthe Rat (1/14/82) DuPont, Haskell Lab, C-8 Inhalation: Embryo-Fetal Toxicityand Teratogenicity Study in the Rat (1/14/82) DuPont, Haskell Lab, FC-143 Occluded Skin Test on Rabbits (1/28/82) Riker Labs. Oral Teratology Studyof T-3141C0C in Rabbits (for 3M) (2123/82) DuPont Haskell Lab, 14-Day Feeding Study in Male and Female Mice (3/8/82) MeKusick, B.C., DuPont Memo Re: Report of FC-143 Teratogenic Studies to EPA (3/15/82) DuPont, Haskell Lab, Placental Transfer of 14C-Labfilled C-8 in the Rat (5/18/82) DuPont, Haskell Lab., Mouse feeding Study - 21 days (5/25/82) DuPont, Haskell Lab, Effect of Cholestyramine on the Elimination of APFO FromRatsand Mice (9/17/82) DuPont, Haskell Lab, 14-Day Feeding Study in Male and Female Mice (10/1/82) Riker Labs, Acute Oral Toxicity Screen With T-3290C0C in Albino Rats (for 3M) (11/5/82) DuPont, Haskell Lab., Excretion and Disposition of APFO in Male and Female Rats, Mice, Hamsters, and Rabbits (11/12/82) Kennedy, G. L., DuPont Interim Report: Evaluationof Sex/Species Differences in Response to C-8 (1/14/83) 000010 "4 LE 1760 + + . 1984 . . + + 1985 . + . 1986 + 1987 . DuPont Haskell Lab., Acute Oral Toxicity ofFC-143 As A FunctionofAge in Rats (2/1/83) DuPont Haskell Lab, C-8 Liver Weights in Rats and Mice: Oral Administration To Males and Females (5/18/83) Oldon, C.T. and Anderson, M.E., TPheeArcutfelToxuicoityrofooctanoiacnd PTeorxfilcuoolr.oAdpepcla.noPihcaArcmi.ds36i2n-M3a7l2e(R19a8t3s)andEffectsonTissue FattyAcids, 70 Staples, R.E., Burgess, B.A., and Kerns, W.D., TheEmbryo-FetalToxicityand `Tea Potetntio al og fAPe FOn inti heRact, 4 Fd. Appl. Toxicol. 429-440 (1984) EJlimoinahtiJno.nDo.sf,GCioabrsbnoonn,,-S1.4iJ.naRnadtOsbAefrteRr.EA.d,mCinhiosltreasttioynroafmAiPnFeO-EornhPaFFnOecSc,eadl4 Fd. Appl. Toxicol. 972-76 (1984) DuPont Haskell Lab, Acute Oral EffectsofC-8 and Ethanol in the Rat (10/8/84) TDouxPiocnittyoHafskFellulorLoacb.h,emDiactaalsSu(FmCm-a1r4y3)RteopoDratphonniTaesMtasgfnoar A(cWuatteearnFdleCa)hr(o1n1i/1c/84) Ikeda,T., Aiba,K., etal, The InductionofPeroxisomePoliferationinRat Liver byPerfluorinatedFatty Acids,Metabolically InertDerivativesofFattyAcids, 98 J. Biochem. 475-82 (1985). DuPont Haskell Lab., Approximate Lethal Concentration by Inhalation (ALC) of APFO (6/3/85) Kennedy, G.L., DTermoal xicofiAPt FO,y81 Tox. Appl. Pharm. 348-55 (1985) Kennedy, GL. Hall, G.T. etal.InhalationToxicityofAPFO, 24 Fd. Chem. Tox. 1325-29 (1986). Pastoor, T.P., Lee, K.P. et al, BMioco hemr icalpandhologStui diescofa APFlO- In(H d19u8c7e e)d pato andm Pere oxjog mePa rolifl eraty ion, 47 Exp. Molec. Path. 98-109 000011 gs LE 1761 . + + 1988 + + 1989 + . + 199% + 1991 + . + 1992 + Kennedy,G.L.,Increase in MouseLiver WeightFollowingFeeding ofAPFOand Related Fluorochemicals, Tox. Letters 39 (2-3): 295-300 (Dec. 1987) Riker Labs, Two-Year Oral (Diet) Toxicity/Carcinogenicity Study of Fluorochemical FC-143 inRats (for 3M) (8/28/87) Sykes, G. DuPont Memo. Re: ReviewofTwo-Year Toxicity/Carcinogenicity Study of Fluorochemical FC-143 in Rats (10/29/87) Perkins, RG., 3M Memo. Re: Summaryof Reviewofthe FC-143 Two-Year Feeding Study Report to be Presented at 1/7/88 Meeting With DuPont (1/5/88) DuPont Haskell Lab, DuPont Memo Re: Review of APFO According to EQC Guidelines for Control of Carcinogenic and Reproductive Risks (2/29/38) AKiPnEnOe,y,2L7 AFd,. CChhreomm.eyTo,xNi.cCo.l,. and Kennedy, 465-68 (1989) G.L., AIcuntehalaTtoxiicioty onf `YlinEen,xM.o,cfHPaFrnhOiAjeairnuitt,hHei.M,aeltoeal.R, natS, 6t 5 Phiarmmb.y&u OeTsotxl r.ad2ia7o4l-ot 7f7t(i h1e9U8o r9i)nn ary Reinhardt, C.F., DuPont's TSCA 8(E) Letter Re: APFO (9/27/89) Yiinen, M,, Kojo, A. et al, DispositionofPFOA intheRatAferSingleand `Subchronic Administration, 44 Bull. Env. Contam. Tox. 46-53 (1990) Vanden Heuvel, LP., Kuslikis. BI. et al.,TissueDistribution,Metabolism,and EliminationofPFOAinMaleandFemaleRats, 6 J. Biochem. Tox. 83-92 (1991) PAFbOdeAll.ataiPf,erAo.xGi.,soPmreeaPtr,oVl.i,feertatalo.r,,Th11e1MToodxu.laAtpipoln. oPfhRaartm.Li5v3e0r-C3a7rc(i1n9o9g1e)nesis by PNeirlossxoins,oRm.e,PBreoiljief,erBa.,teorts,al7..8OHCnheetmh.pe-MBaeioclth.aonIincstemraoacftrtiohcnes i23n5-2o50g(e199n1)citoyf Kuslikis, BLL, Vanden Heuvel. JP, and Peterson, R E.. LEacvkoif dencFeor FPeePrmfaellueorrRoafdtesc,la7nJou.y]Bo-ioorr cheom. oToc x. t25-a29n(19o92)yl-ACForomaetionnizn Myalmeaend -6- 000012 LE 1762 . VIanndenhHeiEufvfebelc,tioJ.fP.Tt,esDtaoovsitsre,rJoyn.eW,.e7,tJa.l.B,iRoecnhaeml.ExTcorxe.ti3o1n-o36f(P1F9O9A2) inMaleRats: + Goeckkee , CM. Jtahmeett], BM. and Reo, N.V., AotCompbayraPtaievesToxicolNoagical Spectroscopy, 5 Chem. Res. Tox. 512-519 (1992) + GClaaveerlt, HP, SriPnFiOvAasaon,nSH.iA.eta.,EffectsoftShePeroxisomRePrToliferators iRnats4,3 Biochem. Pharm. 1353-59 (1992) + Cook, J.C, Murray, SM,etal.InductionofLevdigCellAdenomasbyAPFO:A Possible Endocrine-RelatedMechanism, 113 Tox. Appl. Pharm. 209-217 (1992) . `Takagi, A, Sai, K., etal., HepatiosanmEarelyBgiomaarklerfyor 'ToxH. Oencpol.a19t5-o49c(1I9an9d2ur)cecdbiyPnerooxigsoemePnroelifseraitosrs, 11(3) J. Env. Path. + Vanden 2Heuvel, J.P, Kuslikis,A B.L, anndthe PeterPlag.son, R E.13,CovalenTtBindingof 52 Chem.-Biol. Interactions 317-328 (1992) . Haughom, B. and Spydevold, O., TheMechanismUnderlyingthe Hypolipemic Ef7f2e(c1t9o92f)PFOA,PFOSAandClofibricAcid, 1128 Biochem. Biophys. Acta., 65- 1993 Hazelton Wisconsin, Inc., 13-Week Dietary Toxicity Study With T-5180 APFO (CAS No. 3825-26-1) in Male Rats (for 3M) (5/17/93) + Cook, J.C, DuPont Memo Re: Potentially Reportable Toxicity Data [TSCA 8(e)] Regarding C-8 (9/23/93) + Zobel, LR. 3M Letter to USEPA Under TSCA 8(c) Re: Supplemental Notice Regarding C-8 (10/11/93) Reinhardt, C.F., DuPont Draft Letter to USEPA Under TSCA 8(e) Re: 2-Year Bioassay in Rats with C-8 (10/13/93) 000013 ER LE 1763 + 1994 . . 1995 . . . . . . . . . Olsesonn, U,, Sundber;g, C., etal, IFurthnerS=tvudieosonlthevemeofSnelentium APcidhanadPrFOAmanadtche okineotfCilofcibraste, 46 Biochem. Pharm. 1805-1810 (1993) Frame, S.R., DuPont Letter to 3M Re: DuPont Review of Pancreases of HighDose Male Rats From 3M's 2-year FC-143 Study (4/21/94) DuPont Haskell Lab., DuPont Memo Re: Available Toxicity Literature for APFO (6/1/94) DuPont Haskell Lab., Static, Acute, 96-Hour LCS0 of H-19704 toBluegill Sunfish (8/26/94) 3M Company, Assessment of the Bioaccummulative Properties ofAPFO: Static Fish Test (5/31/95) T.R. Wilbury Lab., Acute ToxicityofL-13492 to the Fathead Minnow, Pimephales Promelas (for 3M) (7/13/95) T.R. Wilbury Lab., Acute Toxicity ofL-13492 to the Daphnid, Daphnia Magna (for 3M) (7/13/95) 3M Env. Lab. Inhibitory Effect of L-13492 to Microbics' Microtox `Toxicity Analyzer System (7/26/95) 3M Env. Lab, Inhibitory Effects of L-13492 on Activated Sludge Respiration (7126/1950 TF.rRe.shWwialtbeurrAylgLaa,b.S,eGlrenoawstthruamndCaRperpriocdoumcuttiuomn Toxicity (for 3M) T(e8s/3t/w9i5)th L-13492 and the T.R. Wilbury Lab., Acute Toxicity of N2803-3 to the Fathead Minnow, Pimephales Promelas (for 3M) (11/16/95) T.R. Wilbury Lab., Acute Toxicity of N2803-4 to the Fathead Minnow, Pimephales Promelas (for 3M) (11/21/95) T.R. Wilbury Lab., Growth and Reproduction `Toxicity Test With N2803-2 and the Freshwater Alga, Selenastrum Capricomutum (for 3M) (11/28/95) 000014 FR LE 1764 + Biegel, L.B,, Liu, R.C., etal,EffectsofAPFQon LevdigCellFunction:In Vitro,in Vivo,and ex VivoStudies, 134 Tox. Appl. Pharm. 18-25 (1995) Cai. Appelkupisyt, E-L. and DePierre, JW.WY.,,Hepatic OxidataitivveeStresStres sand PeroxisomeProliferators, 10 J. Biochem. Tox. 87-94 (1995) . Fort, F.L., Miyajima,H.,et al., MechanisonforSpecies-SpecificInduction of LeydigCellTumorsinRatsbyLansoprazole, 26 Fd. Appl. Tox. 191-202 (1995) + Filliben, T.A., DuPont Memo Re: Multiple Dose Gavage Summaries (6/21/95) 199 + + + + + + . 1997 . . TR. Wilbury Lab., Growth and Reproduction Toxicity Test with N2803-4 and the Freshwater Alga, Selenastrum Capricomutum (for 3M) (3/7/96) TR. Wilbury Lab, Acute Toxicity ofN2803-2 to the Daphnid,Daphnia Magna (for 3M) (3/25/96) TR. Wilbury Lab, Acute Toxicity of N2803-4 to the Dapnid, Dapnia Magna (for 3M) (3/25/96) 3MEnv. Lab, Internal Memo/Charts Re: BiotransformationofPFOA (11/11/96) DuPont Haskell Lab, DuPont Memo Re: Available Toxicity Literature for APFO (12720196) Goecke-Flora, C.M. and Reo, N.V.. InfluenceofCarbonChainLengthonthe 9 Chem. Res. Tox. 689-95 (1996) LPiroul,ifRe.r,atHoarhson,nCR.a,taLnedyHduirgtC,elM.lEF.u,nTchteioDniirneVcittErfof,ec3t0oFfdH.epApaptli.cPTeoxr.ox1i0s2o-m1e08 (1996) HXyMephoertohtnyrra,ooiKd.bi,sMmioorgnoenstteirn,cR.-, etMal.e, EftfecatsobEfnPozeyrmloexisiisonzmReaPitroTlenisftegirsa,to1r0s4aCnhde/mo.rBiol. Interactions 131-145 (1997) CMlegeg, Ec.D.,haCnodoakR,elJne.vC.a,niectealts.o, HLuemymdainsgsC;el1l1 HRyepperropdl.asToixaiacnold.Ad1e07n-o1m2a1F(o1r9m9a7)tion: 000015 9. LE 1765 . 1998 . + + + + 1999 + + + + + + Obourn, J.D., Frame, S.R., et al., Mecfh orta hePan ncrei atis cOncm oges nic `EffectsofthePeroxisomeProliferatorWyeth-14,643, 145 Tox. Appl. Pharm. 425-36 (1997) Nabberfeld, D., Butenhoff, Eatty AcidAnalogueFrom FJa.,tteyt aAlc.,iD dLaimesrPrpotel oifnasabFyluc Woyreeestchem -n1t4le y,L6a4nb3e,lAtePdFO, PAEnOnSua,lanMedeOttihnegr)KnownPeroxisomeProliferators, (Presented at 1998 SOT Kennedy, GL, Biegel, LB, etal, Draft "Toxicologyof APFO" (Draft of Manuscript dated 8/10/98) Covance Lab, Draft AbstractofFinal Report for 4-Week Capsule Toxicity Study with APFO in Cynomolgus Monkeys (Unaudited Draftof 9/15/98) Pathology Assoc, Intl, Cell Proliferation Results From Covance Study No. 6329230 (9/16/98) Pathology Assoc. Intl, Pathology ReviewofReported Tumorigenesis in Twoyear Studyof FM-3924 in Rats (11/25/98) Kennedy, G.L, DuPont Memo Re: Results of C-8 Monkey Study (224/99) 3MEnv. Lab., 3M Memo Re: Preliminary Results of Wk. 26 and 27 Liverand Sera in TOX026/T-6889.2 (5/14/99) Covance Lab, Pathology Report for 6329-231 (5/19/99) Lieder, P.H., Memo to APME Subcommittee on APFO Re: Preliminary Analytical Results for C-8 Monkey Study (5/19/99) Covance Lab. Memo Re: Hormone Analyses Data for 26-Week APFO Cynomologus Monkey Study (5127/99) OConnor, J.C, E-mail to Kennedy, G.L. Re: Hormone Data From 26-Week APFO Monkey Study (7/16/99) Covance Lab, Internal Memo Re "Troubling" Data From Monkey Study (7127199) Covance lab., Memo Re: Draft Pathology Report for Study 6329-231 (8/25/99) To. 00004% LE 1766 + Thomford, P., Study (9/8/99) Memo to McKee, P. Re: Hormone Summary for C-8 Monkey + Kennedy, GL. Monkey Study Charts from (9/27/99) Internal DuPont Presentation Re: Results of C- * Covance 1017/99) Lab, Revised Draft of Final Report for 26-Week C- Monkey Study + Pinchot, R, (1072219) Intemal DuPont E-mail Re: Results of 26-Week C-8 Monkey Study * oJfepCs-o8n,,PGF.OWS.,, IZnotneymlalFDCuCPoanndt ZEo-nmyalil7R9e5:0S(u11m/m8a/9r9y) Report on Kinetic Analysis * Thomford, P, Letter to Lieder, C8 Monkey Study (11/12/99) P. (at 3M) Re: Cell Proliferation Data for 26-Week + Covance Monkey Lab, Study Statistical Analyses (11/16/99) of Cholecytokinin Data for 26-Week C-8 Reed, KE, 3M Letter on APFO Re: 6-Month to USEPA Under TSCA 8(e) Re: Substantial C-8 Monkey Study Results (11/19/99) Risk Notice . Shabalina, J.G., Panaretakis, T., et al., EffectsoftheRodentPeroxisome PH roli6fee2rCaetp olrlsa,n2d0H(e1p2a)toCcaarrcciniongoegneens,iPsF2O2A37,-o4n6A(pDoecp.tos1i99s9i)nHumanHepatoma SJecprseoenn,inGg.WD.a,taInftoremCahlemDiucPaolntSoSluutmimoanrsyE:ntPerreplriimsienCaorympKoiunentdisc,AInnacllyusdiisnogfC-8 and PFOS (12/14/99) + DuPont Haskell Lab, H-24215: Static, Oncorhynchus Mykiss (12/20/99) Acute, 96-Hour LCS0 to Rainbow Trout, * Habecker, P., Davis-Keller, L.D.,etal, Cattle Team Report (12/23/99) Tennant Farm Herd Health Investigation: + Mehrota, K., Morgenstem, Influence R., etal.. the HyLevel:pophyILasnd/eorcPetsooximsoymei Enziy nRamtTe ests es, 122 Chemico-Biol. Interactions 73-87 (1999) "u- 000017 LE 1767 - + CNTCICCPA Endocrine Research (with abstractsofstudies) Fund Progress Report For 1/4/99 - 3/8/2000 + DElucnodmebee,ReC:.,2T6h-oWuegehktsC-o8nMEonlnakregyedSMtuodnyk)e(y3/L1i4v/e0r0s)(Report From Univ. of Anilytics Inc, Letter to 3M Medical Dept., Re: Primate TSH Analysis (4/5/00) + EFivnallauya,teC,AbJseoprspotni,oGn.a,nedtaPle,rsAibsstternacceto:fDFelvueolroipnamteendtoChfeAmicMaalmsm(a2l0i0a0n) Screen to + BHiansdeedrlMitoedre,lPtMo,DeasncdriJbeepsPoFn,OGA.KWi.n,etAibsctsr(ac2t0:00D)evelopment ofa Biologically + JBelposoodn,KiGn.eWt.i,csHiinndReartlisteFro,llPo.wMi,ngetRaelp,eaAtbsetdraOcrta:l CDoomspianrgi(s2o0n00o)fPFOA and PFOS + Kennedy, G.L., DuPont Letter to PFOA Studies (5/25/00) USEPA Transmitting Summariesof APFO and Weppner, and PFOS W.A., 3MLetterto Studies (5/25/00) USEPA Transmitting Information on 3M PFOA + Butenhoff, J, Draft: Toxicity ofAPFO of Oral Dosing (Draft dated 7/28/00) in Cynomolgus Monkeys After 26 Weeks (BUunritvo.n,ofJHG,uelAphStSutduyodyftChoendEufcfteecdt o8f/2P3F/0O0A- o8n/3R1/u0m0)en (Cattle) Fermentation + BSeellcehcetre,d LPe.sAf,luDouroPaolnktylLaetntderFlRueo:roSaelcktyilonSu7b1(s1t)a(nbc)esNo(t9i/c1e/0-0)The Toxicity of + Pathology Assoc, Intl, Draft Toxicity Study with APFO in Cell Proliferation Report for 26-Week Cynomolgus Monkeys (9/29/00) Capsule + Rurak, D., Endocrine DuPont E-Mail Re: Disruption (11/6/00) University of Guelph Testing of PFOA for + Covance Monkeys lab., Draft 4-Week (Audited Draft of Capsule Toxicity 11/21/00) Study With APFO in Cynomolgus 000018 -12LE 1768 + 2001 . . + . + + + + + + + + + Becher, L.A., DuPont Section 71(1)(b) Notice - The ToxicityofSelected Perfluoroalkyl and Fluoroalkyl Substances (11/30/00) Biegel, L.B., Hurtt, ME, et al.,, ME echx anit smsorf ahep Tuma orInt duci tionc by PeroxisomeProliferatorsinMaleCDRats, 60 Tox. Sciences 44-55 (2001) Kudo, N., Suzuki, E., et al., Comop ftha eElr imini atis onBo etwn een PCehrefml.u-oBriionla.teIdnFtaetrtayctAicoindss20W3i-t2h1D6i(f2f0e0re1n)tCarbonChainLength in Rats, 134 Burton, JH, Preliminary Report of Effect of PFOA-Contaminated Water on. Cattle Rumen (Univ. of Guelph Study Conducted 1/28/01 - 1/28/01) EnO'dCoocnrnionre,-AJ.cCt.,iAvenCAolmtpeomuantdisve,tJoothhnseEHoDpSkTiAnsCSUcnirve.enCienntgeBratftoerrAylfteorrnDaettievecstitnog `Animal Testing Workshop. (12/4/01) Elcombe, C., CharacterizationofAPFO-Induced Liver Growth in Cynomolgus Monkeys (Report From Univ. of Dundee Re: 26-Week C-8 Monkey Study) (2001) Universityof Guelph Notes Summary for 3/2/01 Meeting (3/16/01) Kennedy, G.L. Internal DuPont Chart Re: Mechanistic Studies - APFO: Pancreatic Effects (3/6/01) Burton, JH, Report on Effect of PFOA Contaminated Water on Cattle Rumen Protozoa and Bacteria (Univ. of Guelph Study Conducted 3/8/01 - 3/12/01) Purdy, R., Charts from Presentation on Perfluoroalkanoic Acids (3/26/01) Martin, L.W., Solomon, K.R., etal, Dietary Accumulation and Bioaccumulation ofPerfluorinated Acids in Juvenile Rainbow Trout (Presented at SETAC Meeting 5/01) DuPont, Intemal Charts Re: Toxicology and Descriptive Biology: APFO (5/4/01) Boudreau, T.M,, University of Guelph Charts Re: PFOA and PFOS Acids II `Surfactant Toxicity Towards Aquatic Plants (presented at meeting on 5/01) Ranshotyn, G., APME Letter to DuPont Attaching Copy of Agreement Between APME and DuPont to Develop a Physiological Based Kinetic Model for APFO (6120001) 000019 -13- LE 1769 + Santoro, M.A. 3MLetterto USEPA Re: Additional Information PFOS and Related Compounds (6/28/01) + DuPont, Acute Toxicity Bioassay Report for Washington Works, W. VA. Plant Outfall Into Ohio River (8/1/01) + Butenhoff, J, etal.Draftof Manuscript: Toxicity of APFO in Male Cynomolgus MonkeysAfterChronic Oral Dosing (8/31/01) + Rurak, D., DuPont Letter to USEPA and WVDEP Responding to 7/24/01 Request for Information on C- (8/31/01) + Rurak, D, DuPont Letter to USEPA and WVDEP Responding to 7/24/01 Request for Information on C-8 (9/28/01) + DuPont Haskell lab, Charts Re: StatusofPFOA Kinetics and Protein Binding Projects (9/30/01) Abstracts and Summaries of SETAC North America Perfluorochemicals `Symposium Topics (11/12/01) + Jepson, G.W., Charts Re: APME sponsored PFOA Kinetics Research Project: Interim Technical Progress Update (11/13/01) + McConnell E. E. and Foster, J R., H18636: Slide ReviewofPancreas Lesions From DuPont APFO Study (Reviewed 11/28/01 - 11/29/01) + DuPont Haskell Lab, Protein Binding of PFOA (For APME) (12/01) + C. Wilkinson, LLC, Memorandum to 3M and DuPont Re: Perfluorooctanoate Review (12/8/01) + Product Safety Labs., H-24921: Dermal Sensitization Test - Buehler Method (For DuPont) (12/17/01) + Covance Lab, Final Report: 4-Week Capsule Toxicity Study with APFO in Cynomolgus Monkeys (For APME) (12/18/01) + Covance Lab, Final Report: 26-Week Capsule Toxicity Study With APFO in Cynomolgus Monkeys (For APME) (12/18/01) 000020 "14. LE 1770 + + 2002 + + + + + + + + PeMrofrlouio,rYo.a,lkYaannooi,cHA.c,iedtsa,l,74DeBtulelr.miCnhaetmi.onSoofc.AcJiadpiatny6C6o7n-s6t7a2nt(s2o0f01) DuPont, Overview of APFO Published and Unpublished Toxicity Literature oo) Belcher, L.A., DuPont Letter Re: Section 71(1)(b) Notice - The Toxicity of Selected Perfluoroalkyl and Fluoroalkyl Substances (1/24/02) Cook, J.C. and Corton, C., Draft: Non-Hepatic Tumor TargetSites (Draft Chapter for Book on Peroxisome Proliferators) (Draft dated 1/9/02) Cook, J.C, Draft PFOA Case Study (Draft Chapter for Book on Peroxisome Proliferators) (Draft dated 1/9/02) DuPont, Chants from SPVFMG Meeting with USEPA and ATSDR Re: APFO (130002) Kennedy, G.L. DuPont Charts Re: APFO Toxicology & Environmental Fate and Effects (2/02) DuPont, Response to Interrogatory No. 1 of Plaintiffs' First Set of Interrogatories in Leach, et al. v. E.L duPont de Nemours and Co. et al. (Civil Action No. 01-C-608 Wood Cty. W. Va. Cir. Ct) (2/18/02) Argus Research, Oral (Gavage) Two-Generation (One Litter Per Generation) Reproduction StudyofAPFO in Rats (for 3M) (3/26/02) Sanderson, H., Boudreau, TM, et al, Ecological Impact of PFOA on the Zooplankton Community in Indoor Microcosms (Unpublished article, Draft dated 4102) UNDAT+ ED + + Butenhoff, I, Costa, G., et al., Chart Re: ToxicityofAPFO in Cynomolgus Monkeys after 26 WeeksofOral Dosing Chants Re: Toxicokinetics of PFOA (Pilot ADME Data) Jepson, G.W., Hinderliter, P-M., etal, Charts RE: ComparisonofPFOA and PFOS Blood Kinetics in Rats Following Repeated Oral Dosing 000021 "ise LE 1771 + Nabbefeld, D.J., An Investigationofthe Effects of Fluorocarbons on Liver Fatty `Acid-Binding Protein (Masters Thesis) + Executive SummaryofAssays for Cytotoxicity and Cell Transformation for T-2942 COC Using C3H 10T-172 Cell Cultures in Vitro + Coming Hazelton, Abstract of In Vitro Assay Evaluating Ability of T-6564 to Induce Chromosomal Aberrations in Chinese Hamster Ovary (CHO) Cells With `and Without Metabolic Activation Coming Hazelton, Abstract of In Vitro Assay Evaluating AbilityofT-6342 to Induce Chromosomal Aberrations in Chinese Hamster Ovary (CHO) Cells With and Without Metabolic Activation + Coming Hazelton, Summary of Investigationof T-6564 for Mutagenic Activity in the Salmonella-Escherichia Coli/Mammalian-Microsome Reverse Mutation Assay with a Confirmatory Assay + Coming Hazelton, Summary of InvestigationofT-6342 for Mutagenic Activity in the Salmonella-Escherichia Coli/Mammalian-Microsome Reverse Mutation Assay with a Confirmatory Assay + Coming Hazelton, Summaryof Mutagenicity Test on T6364 in an In Vivo Mouse Micronucleus Assay + Coming Hazelton, Summary of Mutagenicity Test on T-6342 in an In Vivo Mouse Micronucleus Assay + Elcombe, C., Mechanisms of APFO-Induced Pancreatic Acinar Cell Tumours in Rats + Chauhan, S,, Criddle, C., and Tiedje, J. Evidence of Biodegradation of Trifluoroacetic Acid (funded by 3M) CasaC4 Animal Toxicity Suis vod 000022 -16LE 1772 1978 * * * 1981 * * 1984 * 1986 . 1991 * * 3MEnv. Lab, Adsorption and FC-143 on Soil (2/27/78) 3MEnv. Lab, Adsorptionof FC-95 and FC-143 on Soil (2227/78) IMEnv. Lab, Biodegradation Studies of Fluorocarbons-II (7/19/78) 3MEnv. Lab, Biosorption of CS-2151 (CS-2070) (8/25/81) 3MEnv. Lab, Chemical Oxygen Demandof CS-2151 (8531/81) Doughty, (829/84) JF., DuPont Memo Re: Summaryof C-8 Water Sampling Program P2aP9rne3ts-c33h:0e4Tr,r(eD1a.9,t8m6G)erno(stEson,fglUIi.ns,dhuestTtarrlai.naE,slnlWavtaiisrootn)nemWeanttera,lB1e4hAacvtiaorHoyfdFrloucohriimn.atHeyddSruorbfiaoclt,ants oZinpfCe-l8, R(J1.021D/u9P1o)nt Memo Re: Interim Report No.2 of Univ. ofDelaware Study Zifel on C-8 R(1I2./5D/9u1P)ont Memo Re: Interim Report No. 3of Univ. of Delaware Study DuPont, 92) RCRA Verification Investigation Report for DuPont Washington Works 1996 * * NDuePwonIntitEaxtpo.rsS,tSautrifoancLtaanbt,s,AAqdudeiotuivsesPoalnydmeCrhiaziantiTornanPsrfoecresAsgefonrtsFl(u2o/r1o3p/o9l6y)mers: PUFoSrCEkPELAe.)e(C1Mr2eg/et1k3,/B9Ion6c)v,iFnieeSlidteT,rWiapsRheipnogrtto:n,PrWeoliomdinCaoruynAtys,seWsessmtenVtirDgriyniRau(nf/oNr. 000023 LE 1773 + 1997 . . . . . 1998 . 1999 * VMaarcieKtayyO,fDT,ypDieGsuOafrdCoh,emAi,caetlaslU,sE ingTvhea EOTChleMoEnudvsir,aon1m5etnEtnva.i l TFoaxnt.eOCghfe4m, 1627-1637 (1996) (DuOPEoCntD,3E0v1alBu)at(i3o/n11o/ft97h)e Biodegradability of C-8 Using the Modified Sturm Test FFeliuroirngo,mAo.nEo.m,eDrusP(o5n/t22M/9e7m) o Re: Microemulsion Polymerization of QST Env. Inc, Chronic Toxicity of Surface Water Samples From the Dry Run Creek Site With the Fathead Minnow, Pimephales Promelas (for USEPA) 797) 13E.1MI3ED9nuvP7.o)nLatb.d,e RNeesmuoltusrsfraonmdACnoalmypsaensoyfFSaociillitaynidnGPraorukenrdswbautregr, SWaemsptlVeisrgfirnoimathe UWoSoEdPACoEunnvt.y,ReWsepsotnsVierTgienaima (C1e1n/t9e7r), Draft Report: DryRunCreek`Washington, EUfRfoSrtG-rPerienleirmiWnoaroydFwianrdidngCsl,ydDer,yLeRtutnerLtaondUfiSlEl,PWAasRhei:ngStmoanl,l WMeasmtVmiarlgiTnriaapping (12/3/98) `MooGdy,rC. aonIdmpFuiaecltd,nedJb.Ay.dFiDrwe-eFiagthtie tngArceotfimvPrietriyf,lun3o3roEacnavrt .boSxciyi.laToteecshn.in2800-2806 (1999) . 3M Company, The Science of Organic Fluorochemistry(2/5/99) . 3M Company, Fluorochemical Use, Distribution and Release Overview (5/26/99) . DWausPhoinntgCtoornp.WoRrekmse,d.WaGsrhoinugpt,oRn,CRWeAstFaVciirligtiyniIanv(e6s/t3i0g/a9t9i)on Report: DuPont . AKsrseeasmesrm,enGt-L(.6/C3.0/a9n9d)Gannon, J., DuPont Charts Re: C-8 Ecological Risk . ABaltatbealmlea,-BMautltteil-lCeitDyuSxtbuudryy: AFciteilvditRieepso(rftorfo3rMC)le(v7e/9l/a9n9d), Tennessee and Decatur R 000024 E1774 . + 2000 * + + 2001 * . * * . . . . . Berti, W.R., DuPont E-Mail Re: Estimates of C-8 in Ohio River (8/11/99) URS Greiner Woodward Clyde, Memo Re: Results of EvaluationofStaining in Shrew Teeth - Dry Run Landfill, Washington, WestVirginia (10/4/99) D3iMspeCrosmipona,nyFa,tSeualnfdonEaftfeedctPser(f3l/1u/o0r0o)chemicals in the Environment: Sources, DuPont, Adsorption-Desorption Screening Studies ofAPFO (5/00)b DuPont, Modeling Releases ofAPFO Into the Ohio River (5/22/00) Geisy, J.P. and Tech. 1339-42 Kannan, (2001) K.,GDlobialstriob f PuFOStiniWilodlinfe, 35 Env. Sci. ILnut,erJfRac,e,OCtotelwliolild,s RSuHr,facaensdAR:enPnhiyes,iAo.cRh.e,miAcaldEngs'g oo AfspAercPtFsOp1a8t3t t-h8e5i A(i2r0o -0W1a)n ter Hansen, KJ, Clemen, L.A, etal, Compound-Specific. Quantitative ChTaercahc.t7e6r6iz-a7t0i(o2n0o0f1O)rganic Fluorochemicalsin Biological Matrices, 35 Env. Sci. Berti, W., DuPont Chan/Abstract Re: APFO Adsorption/Desorption to Soils and Sediments at Washing (3/15/01) ton Wo rk s and 3M Env. Lab., Hydrolysis Reactions of PFOA (3/30/01) (33M/30E/n0v1.) Lab., Characterization Study of PFOA-Phase: Solubility Determination DPiaxtohnw,ayDs.Af.o,r MFleumroochReem:icFallusoirnocIhnceimniecraaltDieocnoPmrpoocessisteiso(nbPyroWcielslsieasm/DR.egWrieldeaytiEonnv. Molecular Sciences Lab, Pacific Northwest Lab. ) (4/4/01) P3FMOEAnv(.4/L2a0b/.0,1S)creening Studies on the `Aqueaus Photolytic Degredation of (E6n/t0r1ix), Inc., Selected Flurochemicals in the Decatur, Alabama Area (for 3M) .3. 000025 LE1775 + GinelFiisys,hJTPi.ssauneds (Kfaonrn3aMn), K(.6,72A0c/c0u1m)ulation ofPFOS and Related Fluorochemicals * GineiMsayr,iJnPe.MaanmdmKaalnsna(nf,orK3.,M)Ac(c6u/m2u0/l0a1t)ionof PFOS and Related Fluorochemicals + GineiMsiyn,kJ.aP.ndanRdivKearnOntatne,rsK.(,foArc3cMu)mu(l6a/t2i0o/n01o)f|PFOS and RelatedFluorochemicals * `WGaetteayr,BiLrP.dsan(fdorKa3nMn)an(,6/K2.0,/0P1R)OS and Related FluorochemicalsinFish-Eatng + GCreaisssyo,sJtPr.eaaVnidrgKiannicnaa,n,frKo.m, tPhReOGS aunodfRlMeelxaiftecdoFalnudorCohcehseampiecaakles iBnaOyys(tfoerr,3M) (6/20/01) + Centre Anal. Labs, Inc, Analysis of PFOS, FOSA, and PFOA from Various Food Matrices Using HPLCFlectospray/Mass Spectrometry (for 3M)(6121/01) + Geowre Anal Lab, Inc, Alfalfa Summary - FOSE Alcohol, Ethyl FOSE Alcohol, PFOS, PFOA, and PFOSA - 3M Plant - Cordova, Illinois (for 3M) (6/21/01) . S3tMudEynv.WaLtaebr.,, SElxuedcguet,ivSeedSiummemnatr,yP:OETnWviErfofnlmueennttaalndMoLnaintdofrililngLMe-auclhtait-eCiSatmyples (6/25/01) * ESl(ol7iu1sr1,9c/eD0o.1Af).H,alMoagbeunray,teSdAOr,geatnailc,ATchiedmsnoInlTyshiesoEnfvFilruoonrompeonl,v4m1er2sNAastuArePo3t2e1n.t2i4al - . - 2002 . DuPont, Alluvial DuPont Lists of Public Water Systems in West Wells in the Sand Formationofthe Ohio River Virginia and (8/30/01) OhioWith Rurak, D., DuPont for Information on Letter to USEPA C-8 (831/01) and'WVDEP Responding to 7/24/01Request Rurak, D., DuPont Letter to USEPA for Information on C-8(9/28/01) and 'WVDEP Responding to 7/24/01Request DuPont DuPont Corp. Remed. Group., DuPont's Compilation of Historical Washington Works Main Plant and Landfills (1/02) C-8 Data: 4. 000028 LE 1776 . Kenedy, G.L., Draft Report Re: The Occurrenceof PFOA in Environmental Dietary and Human Samples (1/02) - UNDATED . DuPont, Response to Interrogatory No. | of Plaintiffs' First Set of Interrogatories in Leach, etal. v. E.I. duPont de Nemours and Co., et al. (Civil Action No. 01-C-608 Wood Cty. W. Va. Cir. Ct.) (2/18/02) Berti, W.R., DuPont Charts Re: Environmental Fate of APFO: Preliminary Studies Modeling APFOinthe Ohio River and Adsorption to Soils and Sediments Clacton Eavirmenal npcOsmbun Sde vod Se 000027 LE1777 "C4 HUMAN HEALTH RISK EVALUATIONS 1954 + DuPont, Memo Re: Handling ofC-8 (6/9/54) 1987 + aSnmidtCh,omHmAun,iDtuyPDornitnkMiengmoWaRtee:rR(e6/q1u2e/s8t7)for Acceptable Levels of C-8 in Blood 1988 + G(Driashcaums,siRngCA,EDLuaPnodntCHEaGskeflorl CL-a8b)M(2e/m15o/8R8e): AEL Committee Meeting Notes + ARePinFhOar(d2t1,2C9/F8.8)and Culpepper, B.W., DuPont Memo Re: Toxicity Review of + SRmeivtihe,wH(.2A/.2,9/D8u8P)ont Memo Re: APFO (C-8) Hazard Assessmentand AEL + 1Du8P8o8nt)Haskell Lab., DuPont AELICEG Assessment/Basis for APFO (C-8) + Lanyon, R.D., DuPont Memo Re: Employee Communication - APFO (C-8) Hazard Assessment and AEL Review (3/24/38) + Graham, R.C., DuPont Haskell Lab. Memo Re: AEL Committee Notes (Discussing AEL and CEG for C-8) (10/17/88) 1991 + DuPont, Memo Re: Request for CEG for APFO in Drinking Water (4/1/91) + Kennedy, GL. DuPont Chars Re: C-8 AELICEG Calculations (5/791) + Graham, R.C., DuPont Haskell Lab. Memo Re: AEL Committee Notes (Discussing AEL and CEG for C-8) (5/8/91) + (D5u/P1o0/n9t1)Haskell Lab, DuPont AELICEG AssessmenBasis for APFO (C-8) + G(Driashcaums,siRn.gC.A,EDLuPaonndtCHEasGkelfolrLCa-b8.)M(6e/m6/o91R)e: AEL Committee Notes + Berg, AS. DuPont Memo Re: DuPont AELS/CEG (6/11/91) 000428 LE1778 + 1992 + + 1993 + + + 1994 + 1996 + 1997 + 1998 + 1999 + + + Graham, R.C. DuPont Memo Re: CEGs for C-8 in Airand Water (10/24/91) Graham, R.C., DuPont Memo Re: CEG for C-8 inAirand Water (1/22/92) Graham, R.C. DuPont Haskell Lab. Memo Re: AEL Committee Notes (Listing CEG for C-8) (2/7/92) Graham, R.C, DuPont Haskell Lab. Memo Re: AEL Committee Notes (Discussing C-8) (11/4/93) DuPont Haskell Lab, DuPont AEL/CEG AssessmentBasis for APFO (C-8) 2/7193) Graham, R.C., DuPont Haskell Lab. Memo Re: AEL Committee Notes (Discussing C-8) (12/13/93) DuPont, Acceptable Exposure Limits (AEL) ListPreface (6/17/94) Ramirez, B., DuPont Memo Re: Occupational Health Review - Organofluorine Compounds (11/8/96) Biegel, LB. DuPont Hazard Characterization for Human Health C- Exposure 9797) Trochimowicz, H.J. and Kennedy, G.L., DuPont's Carcinogenic and Developmental Toxicity Hazard Determinations: APFO (10/30/98) Westphal, P., Handwritten Notes/Calculations of URS Greiner Woodward Clyde Re: AELS/CEGs for APFO/C-8 (for DuPont) (4/30/99) Kennedy, G.L, DuPont Draft Memo Re: APFO Acceptable Daily Intake Community (5/25/99) DuPont, Draft Proposal to Conduct A General Human Health and Environmental Effects Risk Analysis On C-8 (6/29/99) 000029 oe LE1779 + + + 2000 + . + + + + + + 2001 + + + + + Roy,R., 3M Memo Re: Draft Drinking Water Health Advisory (DWHA) - PFOS 17199) Graham, R.C. DuPont Haskell Lab. Memo Re: AEL Committee Notes (Discussing AELs and CEGs for C-8) (12/14/99) Playtis, A, DuPont Memoto All Employees Re: Results of 1999 C-8 Primate Study (12/16/99) Walton, L.A, W.L. Gor&e Assoc. Inc. Letterto Maryland Dept.ofEnv. Re: Request for Approvalof Fenceline Screening Level For APFO (3/10/00) Playtis, A.J., DuPont Memo Re: A3 TLV for C-8 (6/9/00) Ramsey, H.D, DuPont Memo Re: PFOA AEL/CEG Calculations (7/7/00) DuPont Haskell Lab, DuPont Acceptable Exposure Limits (AL) List/Preface (8/21/00) DuPont Haskell Lab, DuPont AEL/CEG Assessment/Basis for APFO (C-8) (8124/00) Graham, R.C., DuPont Chart Summarizing AEL Committee Actions on APFO (C8) (9/28/00) USEPA, OPPTS, Revised Hazard Assessment and Biomonitoring Data on PFOS (10/23/00) USEPA, OPPTS, Draft Assessment Of PFOS And Its Salts (12/00) DuPont, Exposure Evaluation for New [C-8] Process at Fayetteville Site (8220/01) Rurak,D., DuPont Letter to USEPA and WVDEP Responding to 7/24/01 Request for Information on C-8 (8/31/01) Rurak,D., DuPont Letter to USEPA and WVDEP Responding to 7/24/01 Request for Information on C-8 (9/28/01) Eviron Intl Corp, Draft: A Reviewofthe Toxicology of PFOA (I1/01) DuPont, Chart Re: APFO Exposure Guideline Safety Factors (11/7/01) 3. 000030 LE 1780 2002 + + + + + + + Evi-ron atl Corp, Draft: A Hazard Namative for PFOA (1/02) Eviron Int'l Corp, Final Report: A Hazard Narrative for PFOA (1/24/02) 3M Medical Dept, 3M Lifetime Drinking Water Health Advisory for PFOA (1728/02) DinuPLoeancth,,Reetsaplo.nvs.eEt.oI IdnutPerornotgadteorNyemNoo.ur|soafnPdlaCiont.ifeft'alF.ir(sCtiSveiltoAfcItnitoenrrNoog.atories 01-C-608 Wood Cty. W. Va. Cir. Ct) (2/18/02) USEPA, OPPTS, Draft Hazard Assessment of PFOA and ts Salts (2/20/02) Tewa Tech, Inc. Discussion Points Relating to the Assessmentof Health Risk From Exposure to APFO/PFOA (3/7/02) Ullrich, D.A, USEPA (Region 5) Letter Re: StatusofPFOA Health Assessment (@n102) UNDAT+ ED + + + + + DuPont, Various Pages of Handwritten Notes/Calculations Re: CEGfor C-8 in Drinking Water DuPont, Handwritten Notes/Calculations Re: Contribution of Water to Blood Levels (C-8) DuPont, Chart Re: "Backofthe Envelope" Estimationof C-8 Levels in Blood Following 24 HR Exposure at the CEGa. DuPont, Chart Re: "What Are The Issues Associated With Development of Remediation Screening Levels for C-82" Kennedy, G.L, DuPont Charts Re: APFO (C-8) (Discussing Historyof C-8 AELS/CEGs) DuPont, Chart Re: APFO Exposure Standards H\ClusAcionC-8 Hume Heath Risk Evalution pd -4- 000031 LE 1781 "C8 HUMAN HEALTH/EPIDEMIOLOGY STUDIES 1978 + + + 1979 + + + 1980 + + + + 1981 + Karrh, B.W., DuPont Memo Re: Medical Examinations for Fluorochemical Workers (7/24/78) Power, Y.L, DuPont Memo Re: ReviewofMedical Records of Employees With C8 Exposure (9/20/78) Bower, W.A., DuPont Memo Re: C-8 Exposure Medical Surveillance (9/28/78) Hood, D.B., DuPont Memo Re: APFO (FC-143) Skin Absorption Studies Recommendation For (7/30/79) Fayerweather, W.E., DuPont Memo Re: Status Report on Washington Works Liver Function Survey and Coronary Heart Disease Mortality Study (8/28/79) 3M Company, Analysis of Selected Decatur Employee Serum for Sulfonic and Carboxylic Fluorochemicals (10/4/79) Ubel,FA,Sorenson,S.D.,andRoach,D.E. HealthStatusofPlantWorkers EF x5p84ol-s5e8ud9to (o19r80)ochemiPrceliaminlarysRe-porAt, 41 Am. Ind. Hyg. Assoc. J. Schuman, L.M. and Mandel, 1S., an Epidemiologic Mortality Study of Employeaest the Chemolite Plant (for 3M) (2/80) Brewster, V.A, DuPont Memo Re: 6/4/80 Memo Requesting Comments on the Washington Works Communication Draft "Fluorosurfactants in Blood" (6/9/80) Burger, R.J., DuPont Memo Re: Fluorosurfactants in Blood (6/12/80) Fayerweather, W.E., Draft Liver Study of Washington Works Employees Exposed to C-8: Results of Blood Biochemistry Testing (Draft of 6/16/80) Fayerweather, W.E, Liver Study of Washington Works Employees Exposed to C8: Resultsof Blood Biochemistry Testing (1/15/81) 000032 LE 1782 . + + 1982 . + + + 1983 + + 1989 . 19% 1991 + Fayerweather, W.E., MI and CHD Study at Washington WorksPlant (1/22/81) Kah, Effects Bo.nW,P,reDgunPaontntWaMsehminogtRoen: AWoPrFkOs (FFeCm-a1l4e3s)(C3/-285/C8o1m)pounds - Potential DEumPpolnoty,eeCshaBritrtShusmamnadriPzriegnnganCc-i8esS/aSmtpaltuisng(4R/e8s1u)lts: Washington Works Fayerweather, W.E., 8: Resultsof Blood Liver Study of Washington Works Biochemistry Testing (S/31/81) Employees Exposed to C- DPoruogghrtaym,(J2.1E./,82D)uPont Memo Re: Washington Works: APFO (C-8) Control Power, Y.L, 1682) DuPont Memo Re: C-8 Liver Function Study (with Attached Data) Loshiavo, 1G. Drinking Ohio RDiuvPeornWtatMeerm(o10/R1e9:/8E2s)timate of Human C-8 Exposure From Karth, B.W., DuPont Memo Re: C-8 Exposure at Washington Works (11/23/82) Fayerweather, W.E., Update of 1/28/81 Liver `Works Employees Exposed to C-8 (Draft #1) Function (1/7/83) Study of Washington Fayerweather, W.E, Update of 1/28/81 Liver Function Study of Washington Works Employees Exposed to C-8 (Draft #2) (1/28/83) Power, Y.L, Draft Memo Re: C-8 Liver Function Study (with attached Data) (6/6/83) oHfaTuegftlomotn,VHa.paonrd,H$aeTriedns,skJr..,PNuolr.moLnaaergyefEodreenm.aa58n4d-P8e5ri(c1a9r8d9i)ti(sEAnfgtleirsIhnhalation Translation) Smith, HA. DuPont Memo Re: Review of Washington Works C-8 Data: Personnel Air Monitoring and Blood (4/90) 000033 FAamyoernwgeaWtahsehri,nWg.tEo.n, WDourPkosntEmMpelmoyoeeRes:WCirtohssP-oSteecnttiiaolnaElxSptousduyroeftLoiCv-e8r(E1n0/z4y/m9e1)s -2- LE 1783 + 1992 + + + 1993 . + + + + + 199% + + + Kams, ME. `Washington and Fayerweather, W.E, Works Site (12/31/91) A Case-Control Study of Leukemiaatthe DuPont, Charts Re: Results of Liver StudyofWashington Works Employees (112192) Anderson, WP, DuPont Memo onJanuary 8, 1992 (1/21/92) Re: World-Wide Status Review for APFO (C-8) Gilliland, F.D, Fluorocarbons and Human Health: Studiesinan Occupational Cohort (Thesis Submitted to Univ. ofMinnesota) (10/92) Gilliland, F.D. and Mandel, J.S., MorAt monagEl mpli oveets oy fa PerfluorAociodPcrotducatinonoPlianct, 35. J. Oce. Med. 950-954 (9/93) Power, Y.L, DuPont Memo Re: Review of C-8 [Washington Works Employee Data] and Recommendations (11/3/93) Playtis, AJ. DuPont Memo Re: Work Historiesof Specific Cancer Cases (C-8) (11/15/93) Walrath, J, 11/16/93) DuPont E-Mail Re: Work Histories of Specific Cancer Cases (C-8) Playtis, AJ, DuPont Memo Re: Clarificationof Job Definitions (For 1981 Liver Study Report) (11/22/93) Playis, AJ, DuPont Memo Re: Resultsofthe 1995 Studyof C-8 Blood Levels 13/97) Gilliland, F.D. and Mandel, JS, SerumPFOAandHepaticEnzymes, LiApmo.prJo.tIenidnuss,. aMnedd.Ch5o6le0s-t6e8ro(l1:99A6S)tudyof Occupationally ExposedMen, 329 Walrath, J. Draft DuPont Epidemiology Surveillance Report: Mortality and Cancer Incidence Surveillance at Washington Works (Draftof3/5/96) Playtis, AJ, DuPont Memo to All Employees Re: Mortality and Cancer Incidence Surveillance Updates (6/3/96) 000034 3. LE 1784 . + + + 1997 + + 1998 . + + 1999 + + + + + Walrath, J., Final DuPont Epidemiology Surveillance Report: Mortality and `Cancer Incidence Surveillance at Washington Works (6/30/96) Power, Y.L, DuPont Memo Re: C- Study (Washington Works C-8 Medical Data/Charts) (8/5/96) Zobel, LR. 3M Letter to DuPont Re: 3M PFOA Medical Surveillance Data (9/9/96) Ramirez, B. and Reinhardt, C.F., DuPont Memo Re: Occupational Health Reviews: Orgonofluorine Compounds (11/8/96) DuPont, Summaryofspecial C-8 Sampling Project (9/16/97) Playtis, AJ, DuPont Memo Re: Resultsofthe 1995 Study of C-8 Blood Levels 1397) ReOlpsreond,uGc.tWi.v,eHGiolrlmiloannde,sFi.nD.M,eetnalW.i,tAhnOEcpciudpeamtiioolnoagliEcxIpnovseustriegtaotPioFnOoAf, 40 JOEM. 614-622 (1998) 3M Company, Fluorochemical Exposure Assessment of Decatur Chemical and Film Plant employees (9/3/98) 3M Company, An Epidemiologic Investigation of Plasma Cholecystokinin and Hepatic Function in PFOA Production Workers (9/4/98) Leonard, RC. DuPont Proposal: Surveillance for Exposure, Biopersisteanncde Potential Liver Effects from Workplace Exposure to PFOA (3/25/99) DuPont, C-8 Hazard Communication (5/24/99) Reich, C., 3M letter to USEPA Re: TSCA 8(c) Supplemental Notice Re: Serum Blood Data (5/26/99) Dawson, B.J., DuPont E-Mail Re: C- Medical Surveillance at Chambers Works, N.J. Plant (6/2/99) : Playtis, AJ, Washington Works C- Industrial Hygiene Report (6/30/99) 000035 - LE 1785 + * * . 2000 . + + . . . . * . . Ch9F Oe1lsm9ei9l ns),trGyu WT,eo stBsuirr ns, o JM,cetah l,SeerPurmom dPuFci tOiSonac EnmdplHa oevpeal etisc,a4n1dLJi.p0i.Ed.CM.h7e9m9i-c8a0l6 PDlaawnsto(n9,/2B2/J9,9)DuPont E-Mail Re: C-8 Blood Results for Chambers Works, N.J, ND.aJ.wsPolna,ntB(.9J/,23D/u9P9o)nt Memo Re: C-8 Surveillance Resultsfor Chambers Works, DuPont, Charts Re: C-8 Medical Surveillance Program For Fluoroproducts (1999) COhlosleens,teGr.Wo.l,anBduLriripso,pr.Mo.t,eientsailn.+APCFlaPhsOmPaorodlucteiocn Woyrkserastn,d2oH3epDkartuiigcCEnhnezmiy.meTnosx,. 603-620 (2000) DuPont, Intemal E-Mails Re: Work Histories for Manufacturing Employees at Chambers Works, N.J. Facility With Positive C-8 Results (2/22/00) DuPont, Intemal E-Mails Re: Work Histories for Manufacturing Employees at Chambers Works, N.J. Facility With Positive C-8 Results (2/29/00) Mileti, $.S., DuPont E-Mail Re: Summary C-8 Employee Blood Data (3/21/00) of 3M and DuPont Chambers`Works Playtis, A.J., DuPont E-Mail Re: Works Plant (4/12/00) C-8 Blood `Testing Results for Washington (36M/8/C0o0m)pany, Determination of Serum Half-Livesof Several Fluorochemicals f`oWrepPpFneOrA, Wa.nAd.S,al3tsM(L6e/t8t/e0r0)to USEPA Re: Use and Exposure Information Profile Butenhoff, JM, 3M E-mail to DuPont Re: PFOA Serum Elimination Half.Life Estimate in Humans (6/15/00) IKnefnonremdayt,ioGn.LP.r,ofDiluePfoonrtALPetFtOer(6t/o2U3S/0E0P)A Re: Voluntary Use and Exposure Zobel, L.R., 3MLetterto USEPA Re: TSCA 8(e) Supplemental Data on Half-Life of Perfluorochemicals in Serum (7/13/00) Submission: New 000836 ER LE 1786 + . . . : + 2001 . + . + . . . . Pinchot, RF., DuPont Charts Re: Washington Works Blood Data Summary (7/14/00) Playtis, A.J., DuPont E-Mail Re: C-8 Pensioner BloodData(8/8/00) U.S. Dept.of Health/Human Services, Community Health Status Report: Wood County West Virginia (7/00) Dawson, B.J., DuPont E-Mail Re: Results of C-8 Blood Testing at Chambers Works N.J. Facility (10/19/00) Pinchot, R.F., DuPont Charts Re: Washington Works Blood Data Summary (11/17/00) Reich, C, 3M Letter to USEPA Re: TSCA 8(e) Notice for PFOS-Based Production Process Re: Retrospective Cohort Mortality Study of 3M Decatur Plant (12/15/00) Kennedy, G.L., DuPont Letter to USEPA Re: Supplement to DuPont's 6/23/00 Voluntary Use and Exposure Information Profile for APFO (1/25/01) 3M Medical Dept, Descriptive Summary of Serum Fluorochemical Levels ASumrovenigllEanmcpeloPryoegerPaamrt(i3c/i1p9a/n0t1so)fthe Year 2000 Antwerp Fluorochemical Medical 3M Medical Dept., Descriptive Summary of Serum Fluorochemical Levels Among Employee Participantsof the Year 2000 Decatur Fluorochemical Medical Surveillance Program (3/19/01) 3M Medical Dept, Descriptive SummaryofSerum Fluorochemical Levels Among 236 Building Employees (3/19/01) Jepson, G.W., DuPont Memo Re: Summary of Kinetic AnalysisofPlasma Fluoride for APFO, Zonyl 7950, Zonyl FCC and PFOS (3/21/01) Alexander, B.H., Final Report: Mortality Study of Workers Employed at the 3M Decatur Facility (Univ. of Minn. Study for 3M) (4/26/01) Zobel, L.R., 3M Letter to USEPA Re: TSCA 8(e) Supplemental Notice for Sulfonate-Based and Carboxylic-Based Fluorochemicals (Blood Data) (5/15/01) Kennedy, G.L., DuPont Memo Re: APFO Data Discussed With John Whysner (LIinvcerl,udPes Caharnt Racen:d STreusmtemesa)ra(y5o/fs16H/y,0p1e)rplasia/Neo0p0la0si0a3L7esion Incidence in the -6- LE 1787 . 3M Medical Dept., An Epidemiologic Analysis of Episodes of Care of 3M DecaturChemical and Film Plant Employees, 1993-1998 (5/1 5/01) - CKoenncneendtyr,atGi.oLn.s, RDeufPeornetncLeedttienr1t/o25U/S01EPVoAluRnet:arDyuPUosnet'asnEdntEixrpeoCs-u8reBIlnofoodrmDaattiaon Profile for APFO (5/24/01) + Leonard, RC, DuPont Memo Re: `Works (Summary Data) (6/5/01) Epidemiology Surveillanacte Washington . Adams, G.L., 3M Notice (6/7/01) Letter to USEPA Re: Supplement to 3M's 5/15/01 TSCA 8(c) * U3nMiMteeddiSctaatlesD(e6p/t2,5/d0e1n)ificationofFluorochemicals in Sera ofChildren in the * 3CrMosMseAddiuclatl BDleopotd, DIodneontrisf.(i6c/at2i5o/no0f1F)luorochemicals in Sera ofAmerican Red . Rurak, D., DuPontLetterto USEPAand for Information on C-8(8/31/01) 'WVDEP Responding to 7/24/01Request * NLeowsn)g. "Cancer in Area Above Average" (From 99/01 Edition ofParkersburg . fRourraIkn,foDr.m,atDiuoPnoonnt CLe-t8t(e9r/2to8/U0S1)EPA and 'WVDEP Responding to 7/24/01Request . Hinderliter, P.M. and Jepson, G.W., Draft: A Simple, Conservative `Compartmental Model to Relate APFO Exposure Levels in Humans (Draft Dated 10/10/01) to Estimates of PFO Blood . 3ReMlaMtieodnictaolLiDpeipdt.a,nAd HLeopnagtiitcudCilnianlicAanlalCyhseimsisotfrSyeTreusmt PReFsOulStsanFdroPmFOMaAleLevelsin ESumrpvleoilyleaencPearPtriocigpraanmts(o1f0/t1h1e/0119)94/95, 1997 and 2000 Fluorochemical Medical . 3M Medical Dept., A Cross-Sectional Analysis of Serum PFOS and PFOA in RRDeeeslcuaaltttiusornFFtrloouComlrioMncaihcleaemliaCcnhadelmFiMesemtdarilyc,ealTEhmSypurrlovoieydielHeloanPracmreotPincreio,pgarHntaesmmao(ftt1oh0l/eo1g12/y000a10)ndAnUrtiwnearlpysaisnd 000038 -7- LE 1788 2002 + iDnuPLoenatch,,Reetsaplo.nvs. eE.tIo. IdnutPerornotgadteorNyeNmoo.ur|soafnPdlaCinot.iffest'aF.ir(sCtiSvieltoAfctIinotnerNroo.gatories 01-C-608 Wood Cty. W. Va. Cir. Ct) (2/18/02) UNDAT+ ED + DuPont, DuPont Memo Re: Overview of EpidemiologyStudieson PFOA Done at DuPont (undated - post 1996) DuPont, DuPont Memo Re: C-8 in Blood Monitoring Results in FLPR Dordrecht Facility (undate-d post 2000) HACHsActonC:4 HarmanHeal EpidemicogySidis pd 000039 -3- LE 1789