Document bad8znagv7EEr7xpBZOyvaw1y

TABLE 4 A6E OF POPULATIONS Kean Standard Deviation Exposed (204) , " v Questionable Exposure (51) Not Exposed (163) 56.67 10.58 years. 53.30 10.63 years 46.23 t 12.86 years $ -37- 2377T8 TABLE 5 s EXPOSURE vs. ALCOHOL STATUS* Not Exposed Number Percent Questionable Exposure Number Percent Exposed Number Percent Total Never 27 17.09 Former 47 29.75 8 15.69 18 9.38 53 17 33.33 74 38154 138 p N.S. * For definition, see Appendix X. Present 84 53.16 26 50.98 100 52.08 210 Total 158 51 192 401 237779 -38- TABLE 6 " EXPOSURE & VS. *`- \\ SMOKING STATUS* Not Exposed Number Percent ^ Never 47 28.83 Former 72 44.17 Present 44 26.99 Total 163 Questionable Exposure Number Percent Exposed Number Percent 18 35.29 46 22.66 21 41.18 84 41.38 12 23.53 73 35.96 51 ; 203 Total 111 177 129 ,v *. . K " ` , * *v 4* - **. ***.'. P N.S. * '**' , \ # * For definition, see Appendix V. EXPOSURE vs. PACK YEARS SMOKED* Mean t Standard Deviation Exposed (198)' Not Exposed (162) Questionable Exposure (50) 27.04 28.82 15.73 24.01 19.67 23.97 417 4:. *i f/Vr, * p <0.0001 for comparing Exposed to Not Exposed 2377E0 -39- * i f1 TABU: 7 /v FAMILY HISTORY OF ILLNESS * Family History of Asthma 4 Ml Hayfever Acne Eczema Hives Upper G.I. Ulcer Colitis Heart Attack or Angina before Age 60 Heart Attack or Angina after Age 60 m i High Blood Pressure * Cerebrovascular Accident (CVA) High Cholesterol Diabetes Liver Disease Nervous Disorder ro Inherited Disorder Cancer* Exposed =204) l -% 29 14.22 11 <5.39 21 10.29 16 7.84 18 8.82 34 16.67 22 10.78 | : Not Exposed in=163) " ' % ; 19 | 20 1 20 ;9 ; 22 31 ;U 11.66 12.27 12.27 5.52 13.50 19.02 7.98 53 25.98 64 31.37 i 73 35.78 59 28.92 26 12.75 48 23.53 13 c.y,30 i4.7.v; 10 71 34J P ; 36 1 31 ; 62 '3 9 ! 21 ! 35 ;9 : 28 7 I 45 22.09 19.02 38.04 23.93 12.88 21.47 5.52 17.18 4.29 27.78... * Includes Parents and Siblings of Subjects t Not pxnnserf nrnun hac nalfi2 renlvlnn to this Question.. f- Probability . N.S. 0.03 N.S. N.S. N.S. N.S. N.S. N.-S. ' 0.0097 N.S. N.S. N.S. N.S. N.S. N.S. N.S. N.S. Questionable Exposure-' (n**5T) i 1 7 13,73 3 "5*.88 7 13.53 3 5.88 3 .5.88 12 23.53 4 7.84-- <* 14 13 19 14 9 10 5 9 ,2 19 27.45 1 25.49 37.25 27:45 17.65 19,61 80 17.65 3.92 37.25 TABLE 8 HISTORY OF MEDICAL PROBLEMS; ! p4 History of I : I ' i' M *. * .* y n f Chloracne* Acne Vulgaris2 Folliculitis Skin Cancer Chronic Obstructive Pulmonary Disease (COPDj Hypertension. , , Arteriosclerosis Angina Coronary Artery Disease Cerebrovascular Accident (CVA) Upper G1 Ulcer3 Bladder Cancer Prostatic Disease Kidney Stones Exposed fnSzo*r ;! t 176 06.27 ; 20'. 9.80 ` 1 ' :0.49 ; 8 1 3.92 ` 3. 1 1.47 60 ; * M l 0 0.00 : 3 1.47 j . r. j 'W..W*iL- >20*4.9v80 ;* 6 2.94 42 20.59, 2 : 0,98 ; ; J 24 11.76 No^Exgosed l% 0 0.00 48 29.45 2 1.23 4 2.45 2 1.23 36 22.09 1 0.61 2 1.23 10 6.13 2 1.23 9 5.52 1 0.61 6 3.68 16 9.82 V Questionable Exposure Tt f STI 1 t 0 0.00 10 19.61. 0 0.00 1 1.96 1 1.96 4.i 10 0 2 6 1 6 2 2 5 19.61 0.00 3.9| 11.76 1.96 11.76 3; 92 3.92 9.80 1 p< 0.0001 2 p< 0.001 3 p < 0.005 p values for comparing age-adjusted (on basis of age< 50 ys age 5-50) reported occurrence in exposed vs. not exposed ` TABLE 9 History of HISTORY OF MEDICAL PROBLEMS vs. EXPOSURE STATUS BY AGE t> it Exposed Age < 50 * Not Exposed (n=51) iI i '% **. ' Exposed (ri=nrj i 11 Age : 50 ^ o t Exposed (n*63) L '* Chloracne3 Acne Vulgaris2 *3 FoilIcul1t1s Skin Cancer Chronic Obstructive Pulmonary Disease (COPD) Hypertension* *4 Arteriosclerosis Angina Coronary Artery Disease*3 Cerebrovascular Accident (CVA) Upper GI Ulcer Bladder Cancer Prostatic Disease Kidney Stones ' 0.01 <p <0.05 39 76.47 9 17.65 0 0.00 0 0.00 0 0.00 0; 42 2 1 0 .00 42.00 2.00 1.00 ;0.00 ; 9 17.65 14 14.00 0 0.00 0 ; !o.oo 2 3.92 1 ji.-oo 1 1.96 o ]o.oo 0 0.00 0 . lO.OO 7 13.73 0 0.00 1 5: 15.00 0 0.00 3 5.88 3 ]3.00 7 13.73 7 ,(7.00 ' .r- . 1h l1 :1 3 In expqsLed young y $-. ojd ,`RJ.C p < 0.0001 137 89.54 11 7.19 1 0.65 8 5.23 3 1.96 51 33.33 0 0.00 1 0.65 19 12.42 6 3.92 35 22.88 2 1.31 5 3.27 17 11.11 0 0.00 $ 9.52 0 0.00 3 4.76 2 3.17 22 34.92 1 1.59 1 1.59 10 15.87 ' 2 - 3.17 4 6.35 1 1.59 3 4.76 9 14.29 In not exposed young vs. old ^ 0.05 < p < 0.10 In exposed young vs. old ; 4 0.001 < p < o.oi In not exposed young vs. old TABLE 10 i HISTOlRY OF MEDICAL P1ROBLEMS . VS.I'- .. f HISTORY AND/OR PRESENCE:OF CHLORACNE History of Acne Vulgaris* Folliculitis ' Skin Cancer Chronic Obstructive Pulmonary Disease (COPD) Hypertension^ Arteriosclerosis Angina Coronary Artery Disease Cerebrovascular Accident (CVA) Upper GI Ulcer^ . Bladder Cancer Prostatic Disease Kidney Stones 1 p< 0.0001 2 0.001 < p < 0 . 01 t * History and/or Presence (n176r ^I ; %\ 13 *1 7.39 0.57 7 3.9& 3 1.70 55 31.25 0 o.oo 3 1.70 19 10.80 6 3.41 38 21.59 2 .l.i 4 7 3. 98 <i ",' 19 10.80 i - * No History or Presence : ln=i42)12 vL X 65 26.86 2 0.83 6 2.48 3 * 51 1 4 17 3 19 3 9 1/24 21.07 0.41 1.66 7.02 1.24 7.85 1.24 3.72 26 10.74 TABLE j. HISTORY OF MEDICAL PROBLEMS vs. HISTORY AND/OR PRESENCE OF CHLORAGNE BY AGE -44- 237785 History of Acne Vulgaris* Folliculitis Skin Cancer Chronic Obstructive Pulmonary Disease (COPD) Hypertension^ Arteriosclerosis Angina Coronary Artery D i s e a s e ^ Cerebrovascular Accident (CVA) Upper GI Ulcer Bladder Cancer Prostatic Disease Kidney Stones Age < SO' Chloracne Chloracne Ever : Never (n*39) ,% A .j(nw % 5 #V 12-.82 4 8 36.92 0 0,00 2 1.54 ( 0 0.00 . *1 0.77 0 0,00 o 0.00 t 7 /I7.95 0 ,' 2 $.13 1 2.56 116 * 12.31 ; W .jO.OO |1 `>:0:77 lo 0.00 0 4 M b ; 0 0.00 - 6 i5i Ja - 10 7.69 0 0,00 io 0.00 2 5.13., 5 12.82 [A 3.08 12 9.23 1 O.OOOl < p < 0.001 2 6.05 < p < 0.10 3 p < 0.0001 In chloracne hever, young vs. old In chloracne ever/ young vs. old In chloracne never:, young vs. old Chloracne Ever (ri=137) % Age y SO Chloracne X Nevfe "! .*31 8 5.84 17 . is .'ia 1 0.73 0 0.00 7 5.11 3 2.19 5 4.46 3 2.68 48 35.04 . 0 0.00 1 0.73 18 13.14 6 4.38 32 23.36 2 1.46 5 3.65 14 10.22 35 31.25 1 0.89 3 2.68 17 15.18 3 2.68.. 9 8.08 3 2.68 5 4.46 14 12.50 2377S6 i i TABLE 12 j HISTORY OF MEDICAL PROBLEMS VSi ! CHLORACNE STATUS ;IN EXPOSED ONLY History of Acne Vulgaris Folliculitis Skin Cancer Chronic Obstructive Pulmonary Disease (COPD) Hypertension Arteriosclerosis Angina Coronary Artery Disease Cerebrovascular Accident (CVA) Upper GI Ulcer Bladder Cancer Prostatic Disease ' Kidney Stones i History Only i i i n=69) t : > e 8.70 0 0.00 4 5.80 2 2.90 ; } 21 30.43 0 o.oo . ; 1 1.45 ; 5 7.25 j 2 2.90 j 11 15.94 0 0.00 2 2.90 j 10 14.49 j Current (n=iq7) v ,r 7 6.54 1 0.93 .3 2.80 1 0.93 -A. rv 0 2 14 ,4 * 27 2 .5 9 31.78 0.00 1.87 13.08 3.74 25.23 1.87. 4.67 8.41 I No HItetory r! $20}/ ' 1 (n i* 7 25.00 *0 b '.oo i. 3.57 0 0.00 5 17.86 0 0.00 0 0.00 1 3..57 0 0.00 4 14.29 0 .00 1 3.57 5 17.86 TABLE!13 HISTORY OF MEDICAL PROBLEMS vs. CHLORACNE STATUS IN EXPOSED ONLY BY AGE History of Acne Vulgaris Folliculitis Skin Cancer Chronic Obstructive Pul- monary Disease (COPD) Hypertension* Arteriosclerosis Angina^ Coronary Artery Disease^ Cerebrovascular Accident (CVA) Upper GI Ulcer Bladder Cancer Prostatic Disease Kidney Stones History Only w .1 i Aqe < 50 ; Current w ir r 1 .* *?* .... 3 IB.75 2 8.70 0 0.00 4 0.00 0 0.00 0 0.00; 0 0.00 fi 0.00 4|a. 1 6.25 6 26,09 0 0.00 0 j o.oo 0 0.00 " 2 ; 8.70 1 6.25. 0 o.oo: 0 0.00 ; :*. 0.00 No History (nVl2) i* .4! 33.33 0 0.00 0 0.00 0 0.00 2 6 bi!.4 :? 0 16.67 *0.00 0.00 0.00 0.00 1 6.25 J 5 0 0.00 0 0 0.00 2 2 12.50 3 21.74 0.00 8.70 13.04 'll* 0.33 0 Q.00 k 8.33 2 16.67 V s \V history Only (n=53) a A q e > 50 V Current (n=84) at # ; . T NO : History . {n=16j # 3 5.66 5 5.95 3 18.75 0 0.00 1 1.19 :0 ; o.oo 4 7.55 3 `3.57 ` 1 6.25 2 3.77 1 1.19 0 0.00 20 37.74 28 33.33 0 0.00 0 0.00 1 1.89 0 0,00 4 7.55 14 16.67 2 3.77 4 4.76 3 18.75 0 0.00 0 0.00 1 6.25 * 0 0.00 10 18.87 22 6.19 3 18.75 0 0.00 2 2.38 0 0.00 2 3.77 3 3.57 0.00 8 15.09 6 7.14 3 18.75 -46- 237787 } O.OI< p<0.05 2 0.05< p<0.10 For history only, young vs. old For current, young vs. old 2377E8 Finding Chloracne^ 2 Acne Vulgaris Actlnlq Elastosls'* Actinic Keratoses^ Basal Cell Epithelioma Stasis Dermatitis Peyron1e*s Disease^ Folliculitis Hirsutism MNervousness"/Anx1ety Depression Decreased Libido (H/0)^ Impotence, NOS (H/0) V\ *V V- TABLE 14 Significant Clinical Findings In Relation to Exposure Exposed i tn'204) 1 ` X 1 ; 107 52.45 i" 4 1.96 12f.-<' \ '58; 82 j Il 10.29 , 1 6,86 ; 2 . 0 k~98 ' ' 9 ^ 4 . 4 1 ;j ' 11 5.39 ;* 39 19:12 0 17 a'33 V Not Exisosed ' (n !m r % d 0.00 19 11.66 49 30.06 9 5.52 7 4.29 5 3.07 0 0.00 14 .8.59 3 1.84 19 1 1 .6 6 11 6.75 " 4 2.45 4 \ \ 1 Questionable.1 Exposure (n-51) #X 0 0.00 2 3.92 20 39.22 5 9.80 0 0.00 0 0.00 1 V.96 3 5.88 1 1.96 6 11.76 9 17.65 2 3.92 't **'*-. *'N. ,, * v TABLE 14 COtlTIlUlfD Key to p Values. : ~ '" Jb t*i ; 4 1 p < 0.0001 . 2 0.01 < p < 0.05 3 0 .0 0 0 1 < p < o.d&i 4 o.05 < p < 0.10 Age-adjusted comparison of exposed to not exposed Age-adjusted comparison of'exposed to not exposed Age-adjusted comparison of exposed to not exposed Age-adjusted comparison of exposed to not exposed .--fc -48- 23779 237720 Finding Chloracne Acne Vulgaris^ Actinic E l a s t o s l s ^ Actinic Keratoses^ Basal Cell Epithelioma^ Stasis Dermatitis^ Peyronie's Disease FoilIcul11is^ Hirsutism MNervousness**/Anx1 e t / Depression Decreased Libido ( H / 0 ) ^ Impotence, NOS (H/0)6 *8 TABLE 15 SlgnlflcantClInlcal Findings In Relation to Exposure Status by Age Age < Exposed ~(n=5l) '* I % '. . 50 -N o t txposea (N' lOO) % ! .. 23 45-10 I0 0.00 4 `7.84 18 18.00 19 37.25 18 18.00 2 3.92 ;i 1.00 1 1.96 1 1.96 0 ... o.oo *4 7 v 13.73 .i | 0 V' V0 13 0.00 0.00 0.00 1 13.00 2 3.92 1 1.00 4 "K i 4 7.84 15 '*!!}v l 15.00 1.00 t 1.96 t 0 o.oo N. A9e > 5 0 fi. Exposed Not Exposed (n=153) (n63) #% iX 84 0 101 19 13 ` r 3 2 9 29 54.90 0.00 ' 0 0.00 T 1.59 66.01 12.42 31 49.21 . 8 12.70 8.50 7 11.11 0.65 5 7.94 1.96 0 0.00 1.31 1 1.59. 5.88 2 3.17 18.95- ' .,4:- 6.35 35 22.88' 16 10.46 10 ' 15.87 4 6.35 i>:. , i; , J. 1 \* : j,,|; - TABLE. 15 `C O N T I N U E D Key to p Values *^ . \ *; 1 .0. 00 1 < p < 0 . 0 1 2 0.001 < p < 0.01 3 0.0001 < p <0.001 4 p< 0.0001 5 0.001 < P < 0 . 0 1 . 6 0.01< p< 0.05 7 0.0001 <p <0.001 8 0.05 <p< o.io ' 9 0.01 < p < 0.05 In exposed, young vs. old In not exposed, young vs. old In exposed, young vs. old In not exposed, young vs. old In not exposed, young vs. old In not exposed, young vs. old In not exposed, young vs. old In exposed', young vs. o W - In exposed, young vs. old . ^' 237731 2377S2 \ Finding . Acne Vulgaris ^ Actinic Elastosls ^ ,2 Actinic Keratoses Basal Cell Epithelioma Stasis Dermatitis Peyronie's Disease Folliculitis Hirsutism2 "NervousnessH/Anx1ety Depression Decreased Libido (H/0) Impotence, NOS (H/0) ' 0.01 < p < 0.05 2 0.001 < p < 0.01 i1 ' '_J.5 ' J -V . j ; ^' # - - 1-, 1 \ TABLE 1$: # Significant Cllnfcal Findings In .Relation to Chioracne Status In Exposed Only !t 'J : i . ? History Only !. (na69) i I % 1i j Current (n=l07) 1% 1 32 8 4 1 2 .6 ** i 0 9 1.45 46.38 11.59 : i 5.80 : j- 1.45 2.90 j 8.70 0.00 * 13.04 0 0.00 80 74.77 10 9.35 . 9 8.41 1 0.93 , 1 - 0.93 1 0.93 11 10.28 20 18.69 v 13 18.84 6 8.70 20 18.69 10 9.35 In age < 5 0 j In age ^ 50 J ' -m a m 1 NO History (n=28) # "X 3 10.71 8 28.57 3 10.71 1 3.57 0 0.00 0 0.00 2 . 7.14 0 . 0.00 4 14.29 6 21.43 1 3.57 * Finding Acne Vulgaris Actinic Elastosls Actinic Keratoses Basal Cell Epithelioma Stasis Dermatitis Peyronie's Disease Folliculitis 3 Hirsutism "Kervousness'7Anxiety Depression Decreased Libido (H/0)^ Impotence, NOS (H/0) L 1 0.01 < p .< 0.05 0 0.05 < p < 0.10 ft- TABLE 17 Significant fllnlgal Findings In Relation to Chloracne Status In Exposed Only by Age History only n*lb fX 1 6.25 5 31.25 0 0.00 1 6.25 1 6.25 0 0.00 4 25.00 0 0.00 1 6.25 2 12.50 0 0.00 Current- r I x % - = 0 0.00 13 1 r '4.3S ' 0 0.00 0 0.00 0 .,0.00 1 ; 4.35 2 1*. 8.70 13.04.'' 2 8.70 1 4.35 " Ho History n*l2 f 1C 3 ; 25.00 1 : 8.33 1 8.33 0 0.00 o : 0.00 0; 0.00 2 1 16.67 o; 0.00 0{ 0.00 i- 0 0.00 0; 0.00 . History only n353 #X 0 0.00 27 -50.94 8 15.09 3 5.66 0 0..00 2 3.77 2 3.77 0 0.00 8 - 15.09 ii 20.75 6 11.32 * Current n *84 1% 0 0.00 67 79.76 9 10.71 9 10.71 1 1.19 1 1.19 0 0.00 9 10.71 17 20.24 . No History n-ib`. I% 0 0.00 7 43.75 2 12.50 1 6.25 0 0.00 0 . 0.00 0 0.00 0 0.00 4 25.00 18 21.43 9 10.71 6 37.50 1 6.25 In current chloracne, young vs . old In no history chloracne, young Vs. old 3 0.01 < p < 0.05 0.01 < p < 0.05 In -history only chloracne young vs. old In no history chlorache, young vs. old TABLE 18 DISTRfBUTION AND SEVERITY OF CHLORACNE a i Distribution-of Chloracne and Chloracne Scars rn- ~5? . *4. irf Exposed. Group by Site (n=204) Site Face Neck Extremities Trunk Genitals Face (only) Neck (only) Face and Neck (only) Face and Trunk (only) Face, Trunk and. Genitals (only) Extremities (only) Trunk (only) " " ....... Genitals (only.) S c a n (only) * Residual Chloracne #% 98 48.04 17 ' 8.33 4 1.S6 18 . 8.82 15 7.35 67 32.84 3 1.47 8 3.92 5 2.45 0.98 0 0.00 4 1.96 1 0.49 8 3.92 Chloracne Scars #% 13 6.37 9 4.41 0 0.00 6 2.94 0 0.00 10 4.90 5 ; 2.45 1 0.49 2 0.98 0 , 0.00 0 .0 1 0.49 .0 0.00 0 0.Q & Mild #% 67 62.62 Severity of Chloracne (n=107) , Moderate #% 36 33.96 Severe #% 4 3.77 -53- owpi TABLE 19 lSTRJUiTlOM ANOSEVERITY Of ACTINIC ELASTOS.IS r Distribution of Actinic Elastosis by Site \\ V SITE EXPOSED (n-204) #X NOT EXPOSED (n=163) #X Face 113 55.39 46 28.22 Neck 57 27.94 21 12.88 Arms and Hands 9 4.41 4 2.45 Trunk 1 0.49 0 0.00 Face (only) 62 30.39 27 16.56 Neck (only) 7 3.43 3 1.84 Face and Neck (only) 42 20.59 .15 9.20 Face and Trunk (only) 1 0.49 0 0.00 Arms and Hands (only) 0 0.00 0 0.00 Trunk (only) 0 0.00 0 0.00 --4 11 QUESTIONABLE EXPOSURE in #X 18 35.29 8 15.69 3 5.88 0 0.00 11 21.57 2 3.9*2 4 7.84 0 0.00 0 0.00 0 0.00 -vs. Severity of Actinic Elastosis (n=189) MILD #X 6 7 35.44 MODERATE #X 81 43.09 SEVERE #X 41 21.81 237795 f ii ,} l TABLE 20 fr SEVERITY OF CHLORACNE ITI PRESENCE * OF^A*CTINIC ELASTOSIS fi Actinic Elastosis and Chloracne MILO #% 44 55.00 MODERATE #. % 33 41.25 Chloracne Only 23 85.18 3 11.11 TOTAL - *- --V. - ... 6 7 v J . , .. ..36 SEVERE #% 3 3.75 TOTAL oco 1 3.70 4 27 107 0.01 < p <0.05 237736  ; v- TABLE 21 X V I'.SEVERITY OF ACTIfHC ELASTOSIS IN PRESENCE * W OF CHLORACNE * Actinie Elastosis and Chloracne Actinie Elastosis Only TOTAL , MILD #% 18 22.50 MODERATE #% 35 43.75 SEVERE #% 27 33.75 TOTAL 80 '49 44.95 67 46 42.20 81 14 12.84 41 109 189 p <0.005 237737 / / *1 fc' ' TABLE `22 \f 1\ BLOOD PRESSURE , (Normal <140/90 Tor Subjects ^59, <160/95 for Subjects 60) Exposure Category Systolic Normal Abnormal Diastolic N o r m a l ______Abnormal EXPOSED (n=202) #-. X 145 71.78 57 28.22 153 75.74 49 24.26 QUESTIONABLY EXP0SE0 (n=49) * <v JO 41 83.67 8 16.33 39 79.59 10 20.41 NOT i EXPOSED (n=161) % 122 75.78 39 24.22 132 81.99 29 18.01 -Systolic Pressure:' p = ris for comparison of exposed to not exposed. Diastolic Pressure: p = ns for comparison of e x p o s e d ^ not exposed. 237728 TABLE 23 i. t EXPOSUiRE (: VS. i SERUM LIPIOSji Serum Lipid Cholesterol Triglycerides LDL, estimated HOL Exposed n .#(<Abnormal) 200 15( 7.50) 200 29(14.50) 196 15( 7.65) 200 19( 9.50) Not Exposed ' n #(%Abnorma1) 1*63 17(10.43) 1 163 31(19.02) 159 10( 6.9) 163 17(10.43) i ) CO vl <5 CO iCO 1 .is .t Probability N.S. N.S. N.S. N.S. t Questionable 1 Exposure n i(%AbnormaT) . 49 13(26.53) 49 11(22.45) 47 9(19.15) r* 1 > 49 4( 8.16) 1 \ V TABLE ^24 EXPOSURE vs. *SERUM LIPIDS BY .SMOKING STATUS* Serum Lipid Smoking Status Exposed n i(%)Abr\prmal Cholesterol Ne vr Former Present 45 3( 6.67) 83 7 8.43) 71 5( 7.04) Triglycerides Never Former Present 45 . 8(17.78) 83 11(13.25) 71 10(14.08) LDL, estimated Never Former Present 43 3( 6.98) 83 6( 7.23) 69 6( 8.70) * HDL *0 CO -.1 0.oo0 * Never Former Present 45 4( 8.89 83 8( 9.64 71 9 & 6 ) When pack years were considered there were no . it Not Exposed n:! 7 #(&} Abnormal *,( 4/; 5(10.64) 72< 6( B.33) 44/ 6(13.64) `r 47 8(17.02) 72 14(19.44) 44 9(20.45) V Probability \ '1 Questionable Exposure n #(-%)Abnormal N.S; N.S. N.S. 17 3(17.65) 21 . 7(33.33) 11 3(27 .2 7) N.S. N.S. N.S. 17 3(17.65) 21 7(33.33) 11 1( 9.09) 46 31 6.52) 70 1( 1.43) 43, 6(13.95) N.S. N.S* N.S. 17 3(17.65) 19 4(21.05) 11 2(18.18) 47 5(10.64) 72 5 ( 6.94) 4(1 7(15.91) N.S. N.S. N.S. 17 3(17.65) 21 1( 4.76) 11 0( 0.00) i cant differences in all of the lipid parameters. I * 9, * 237BC1 .1; .I Serum Lipid 0o1\ Cholesterol Triglycerides LL, estimated^ HOL12 1 p < 0.015 2 p < 0.05 TABLE 25 CHLORACNE STATUS IN EXPOSED ONLY vs. ;! SERUM LIPID'S % .i . r History Only n i(X)AbnormaTj 67 67 8(11.94) 5( 7.46) . 66 10(15.15) 67 2( 2.99); > . ,n Current if(%)Abnorma1 105 5( 4.76) ;; i05 -20(19.05) +i : 103 3( 2.91) r 105 15(14.29) ' - ,* * * ? * * * --*.. -4ii4 t No History n i {%)Abnormal 28 2( 7.14) 28 4(14.29) 27 2( 7.41) . 28 ' 2(. 7.1.4) ! 1 .* TABLE Z S CHCORACNE STATUS IN EXPOSED .ONLY vs- j SERUM LIPIDS BY SMOKING STATUS Serum Lipid Smoking Status Cholesterol Never Former Present Triglyceride Never Former 1 Present L0L estimated Never Former . Present 1 HDL Never Former * Present CO 1 0.05 < p < 0.10 3 CaD 2 0.001 < p < 0.01 History Only n --- )Abnormal * 18 - 1 2(11,11) 31 3( 9.68) 18 3(16.67) 18 3(16.67) 31 1( 3.23) 18 1( 5.56) 4f- 18 2(11.11) 31 3( 9.68) 17 5(29.41 j 18 0( 0.00) 31 1( 3.23) 18 1( 5.56) j1 ri T '.f 16 42 47 f ' 16 42 : 47 Current "f(tf)Abormal 0( 0.00), 3( 7.14) 2( 4.26). 2(12.50) 9(21.43) 9(19.15) 15 42 46 T i1 :-l 16 42 47 0( 0.00) 2( 4.76) 1( 2-17) 2(12.50) 7(16.67) 6(12.77) vNo History n (%)Abnormal 11 1( 9.09) 10 1(10.00) 6 0( 0.00) 11 3(27.27) 10 1(10.00) 6 0( 0.00) 10 1(10.00) 10 1(10.00) 6 0( 0.00) 11 2(18.18) 10 o( o.oo) 6 O['0yQO) w. ) Pulmonary `"'Function 1 `(parameter 11 FEV.,1.1, 0ri\1i F v c '1 'f e v .1/f'v c *! : : II 1 . 1 MHEFR '' 1fk| 1 1 ih.i1l>1 1* ;. . r* /i fi.MV * i* ` M (>1 i TABLE 27 1 i"I * ... , e x p o s u r e !: ii vs. j PULMONARY TEST FINDINGS Exposed Ml , ,{n=20ir (X)Abnormal N[o(nt=Ertxj5po)sed" # (X)Abnormal 32 15.76 HI 1! i 11 1l 35 , 17.24 I" 32., 11 11 i 1" a 1 ' ' 15.76 23.15 I'i i 11 :1 i' '( <i i\ ! 11 !{ 8ii l1 1. 18 I 1 i* 4.94 6.79 4.94 11.11 i'i it h n ( <iv li i m *i `I i Probability Questionable Exposure *. -- ~i # ;:.(X|Abnonnal 0.0001 0.0038 5 , 9.80 # %- 11 21.57 0.0013 3, 5.88 0.0038 13 25 49 ftl 237504 l Pulmonary Function Parameter FEVi FVC FEVj/FVC MMFR I TABLE 28; EXPOSURE ys. PULMONARY JEST FINDINGS BY SMOKING STATUS Smoking Status Never Former Present Never Former Present Never Former Present Never Former Present - n 45 84 73 45 84 73 45 84 73 45 84 73 Exposed "f(i)Abnonnal 3( 6.67) 10(11.90) . 19(26.03) Not Exposed n , f(l) Abnormal 47 71 44 3( 6.38) 3( 4.23) 2( 4.55). 3( 6.67) 14(16.67) 113(24.66) 47 6(12.77) 71 : 4( 5.63) .44 1( 2.27) 3( 6.67) 11(13.10 10(24.66) ' 4( 0.89) 17(20.24) 26(35.62) 47 : 1( 2.13) 71 1 4,( 5.63) .j 44 ;. 3( 6.02)r 1 '47 'j 3( 6.38) 71 \ 10(14.08) 44 j 5(11.36) * * i E l Probability N.S. N.S. 0.0044 N.S. 0.0551 0.0015 N.S. N.S. 0.0229 N.S. N.S. 0.0059 v. \ Questionable / Exposure. , n `|j(%)Abnormal 18 0( 0.00) 21 3(14.29) 12 ' 2.(16.67) f 18 2(11.11) 21 6(28.57) 12 3(25.00). . 18 0( 0.00). 21 2( 9.52) 12 1( 8.33) 18 1( 5.56) 21 6(28.57) 12 6(50.00) Finding Normal ECG Negative ECG* Sinus Bradycardia Sinus Tachycardia PVCs PAC* s Atrial Fibrillation Intraventricular Conduction Defect Left Anterior Hemiblock 1st Qegree AV Block Right Bundle Branch Block, complete Left Bundle Branch Block, complete Old Anterior Myocardial Infarct Old Inferior Myocardial Infarct True Posterior Myocardial Infarct Digitalis Effect * Normal or not significant findings TABLE; 29; I EXPOSURE( vs, .jj ECG FINDINGS '. ;T ! t #% : ' 6? 3'3.82 *B 39.22 ;i 5.39 0.98 j 17 8.33 ! S 2.45 j l 0.49 ] 5 2.45 t li 5.39 ) 4 1.96 j 6 2.94 1. 2 0.98 j > 3 1.47 { 7 3.i43 ) * * 2 0.98 ,! 2 0.98 i i a Not Exposed " tn163) l , < 71 43.56 43 26.38 5 .3.07 1 0.61 4 2.45 4 2.45 1 0.61 1 0.61 4 2.45 2 1.23 2 1.23 1 0.61 2 1.23 2 1.23 1 0,61 1 1 0.61 Questionable Exposure CFSI)"" lv t . 14 27.45 15 . 29.41 2 3.92 1 1.96 0 0.00 1 1.96 0 0.00 1 1.96 2 3.92 1 1.96 0 0.00 0 0.00 2 3.92 3 5.88 0 0.00 0 0.00 %>./v -65. 237806 i Finding ------ * M ~?' Left Ventricular Hypertrophy Right Ventricular Hypertrophy' Left Atrial Hypertrophy Non-specific ST-T Wave Changes Low Voltage QRS Abnormal P Wave Left Axis Deviation I TABLE 29 CONTINUED EXPOSURE vs. , ECG FINDINGS . iExposed fnWT TI- ' --* 6' 2.94 1 0.49 0.98 >> 4.41 n Ot.49 9 4.41 1t 0.49 | 11 Not Exposed TnMW],' if X 5 3.07 0 0.00 0 0.00 5 3.07 0 0.00 4 2.45 2 1.23 ! V Questionable Exposure (n^T)~ , --v %\ 1 1.95 0 o.oo' 0 0.00 2 3.92 0 0.00 1 1.96 0 0.00 Finding Normal E C O 1 Negative ECG* 2,1 Sinus Bradycardia Sinus Tachycardia PVC`S 3 PAC's 4 -Artlal Fibrillation Intraventricular Conduction Defect left Anterior Hemlblock Ist Degree AV Block Right Bundle Branch Block, complete Left Bundle Branch Block, complete Old Anterior Myocardial Infarct Old Inferior Myocardial Infarct True Posterior Myocardial Infarct Digitalis Effect * Normal or not significant findings TABLE 30 EXPOSURE ; vs. ECO FINDINGrS BY; AGE . I ! 41 Age i 50 Exposed "{n*5Tf l * l Not ~n rE=xipooosei~d i . # . i - * X 22. 43.14 38 74.51 ir* 57 k 88 57.00 88.00 .. I .4,96 1 1.96 , 1 /, 1.96 i2 -ii 0 jr 1 2.00 0.00 1.00 0 0.00 0 0.00 11 0 r0 0.00 0.00 . 1 1.96 :i` 0 0.00 3 5.68 !' 2 2^00 o 2 3.92 i.. 0 1 1.96 0 0.00 t 1 0 0.00 o.qo ?' . 0 .1! 0 i , 1.96 . ' 0 0 .0.00 } 0 0.00 0.00 LOO 0.00 0.00 .0.00 0.00 .1 t ,I j _ \ Exposed Tn=T5IT 1^ Age >, 50 ' JRdt Exposed ' (n=6 3 K i 47 30.72 86 56.21 10 6.54 i 0.65 16 10.46 14 22.22 32 50.79 '3 4.76 1 1.59 3 4.76 5 . 3.27 1 0.65 4. 2.61 8 5.23 2 1.31 5 3.27 2 1.31 3 1.96 7 4.58 1 0.65 2 1.31 4 6.35 1 1.59 1 , 1.59 2 3.17 2 3.17 2 3.17 0 0.00 2 . * 3.17 2 3.17 1 1.59 1 1.59 1 Finding left Ventricular Hypertrophy Right Ventricular Hypertrophy Left Atrial Hypertrophy Non-Specific ST-T Wave Changes Low Voltage QRS Abnormal P Wave ^ Left Axis Deviation p < 0.0001 0.01 < p < 0.05 0.05 < p < 0.10 0.01 < p < 0.05 TAB*LE 30 CONT*!I1NUED . EXPOSURE ); ECG FINDINGS B(V AGE i. Vi: i } Aqe < 50 Exposed 1 , "tn-5.IT *J i Not Exposed :i - ( n S r o r " }i' # * % o o.oq l 1.00 0 0.00 1 1.96 0 ; fo 0.00 0.00 1 1.96 j V 2 0 0.00 | 2 3.92 i!\ o o.ob 0 o i 2.000.00 0.00 1.00 t1, For not expo^d, young vs. old for exposed, }y*oung vs. old For exposed, jyoung vs. old * *j For not exposed, young vs. old i * _i-ji* * it Age ^50 Exposed (n--l'5TF Not Exposed . m=6S) i% #i 6 3.92 1 0.65 1 0.65 8 5.23 1 0.65 7 4.58 1 0.65 *4',' '4 0 0 3 ... :./fr 4 1 6.35 0.00 0.00 ;'4;76 0.00 6.35 1.59 .iWf. 1V. Finding Normal Chest X-Ray 0 Evidence Old Granulomatous Disease Evidence, Arteriosclerosis Evidence, Degenerative Bone Disease g Cardiomegaly Mass Chronic Obstructive Pulmonary Disease (COPD) Aortic Aneurysm Pulmonary Hypertension Blunted Costophrenlc Angle Acute Parenchymal Olsease Elevated Hemi-diaphragms Pleural Thickening Parenchymal Scarring Possible Mass Aortic Valve Disease Trauma 237809 ! f ! ,,:l'. ` .'!{ '. f, TABLE 31 i EXPOSiURE */ ; vs;.-. CHESTIX-RAT FINDINGSi Exposed Tn*204T ; I % : il 94 4 6 .0 8 1 . 60. 29.41; 23 H i-27 ' 15 7 . 3 5 |` V 8 3.92i 5 2. as! 9 i'4.41-:J ' 1 ,0.49* 0 ( o.odi 20 9.8o; - ,0 j 0.00 5* 2 .4 5 15 ; 7 .3 5 13 6 .3 7 6 ; 2.94 0 1 - 0(? 2 : 0-98. Not Exposed In ^163) * % 110 67.48 23 : M -U 12 > 7 . 3 6 4 2.45 2 1.23 3 1.84 3 ` 1-84 0 * 0 .0 0 1 0.61 9 5.52 1 0.61 . 1 ^ . 0.61 5 3.07 9 5.52 y 1 4.29 1 0.61 3 1.04 i ! Questionable Exposure (n=51) >% 36 7 0 .5 9 9 17.65 1 1.96* 2 3.92 0 0.00 1 1.96 1 1.96 1 1.96 0 0.00 2 3.92 0 0.00 2 3.92 1 1.96 0 *0.00 2 3.92 0 0.00 0 0.00 ' *tv 237819 * Finding - Normal Chest X-Ray Evidence, Old Granulomatous 3 4 Disease Evidence, Arteriosclerosis Evidence, Degenerative Bone 4 5 Disease Cardiomegaly Mass Chronic Obstructive Pulmonary Disease (COPD) Aortic Aneurysm Pulmonary Hypertension Blunted Costophrenic Angle Acute Parenchymal Disease Elevated Hemi-diaphragms Pleural Thickening Parenchymal Scarring ^ Possible Mass Aortic Valve Disease Trauma ^ TABLE.32 ' EXPOSURE i 1 vs> * ** CHEST X-RAY FINDINGS BY AGE Exposed TnSfrr 1X .* Age < 50 \ t *> Not Exposed T- - ' & / ' 42 62.35 6 11.76* 82 V 2 .0 0 9 t 9.00 Age >y 50 Exposed (n=153) * TMX Not Ex V t . "X * 52 33.99 28 44.44* 54 35.29 14 22".22 0 0.00 0 0.00 0 0.00 1 1.96 2 3.92 0 0.00 0 0.00 3 5.88 0 0.00 0 0.00 0 0.00 1 1.96 0 0.00 . 0 0.00 0 0.00 0 | 0.00 0 !\:*0.00 S0 ( 0 .0 0 2 12.00 0 ! 0.00 0 i 0.00 . 0 ; 0.00'* ... 3 !r 3.00 0 0.00 !0 ; o . o o ' 2 : 2.00 2 i 2.00 3 j 3.00 1 i 1.00 i 1,1.00 ij 23 15.03 15 9.80 ' 8 5.23 4 2.61 7 4.58 * 1 0.65 0 0.00 17 1 1 .1 1 0 0.00 5 3.27 15 9.00 12 7.84 6 3.92 0 0.00 2 1.31 1Z * 19.05 4 6.35 2 3.17 1 1.59 3 4.76 0 0.00 1 1.59 6 9.52 1 1.59 1 1.59. 3 4.76 7 11.114 6.35 0 0:00 2 -,,I,-"3.17 7 .# ' X ft "*^ , : Wv - ' '< -- . , * TABLE 32 CONTINUED * Key to p Values. i W. t. * < 5 % vs. ^50 Years . ** J r ii ~ 1 p <0.0001 2 p <0.0001 ^ ^ 0.001 < p <0.01 4 0.01 < p < 0.05 5 0.01 < p < 0.05 For exposed, young vs. old For not exposed, young vs. old For exposed, young vs. old For not exposed, young ys. old Tor exposed, young vs. old 237511 237812 BLOOD Calcium Phosphorus BUN Creatinine Uric Acid Glucose (CS) Total Protein Albumin Globulin Albumin/GlobuHn ratio Total Bilirubin* Direct Bilirubin ^ Transaminase, SGO Transaminase, SGP Alkaline Phosphatase LOH Iron i Vi. TABLE 3I 3 .i f ' ' CLIliitAL LABORATORY FINDINGS '' ! vs.! EXPOSURE TATUS Exposed n TfiAbnormal) ,,> 197 0(0.00) 190 3(1.58) 197 ; 8(4.06) 196 2(1.02) 197 12(6.09) 190 14(7.37) 197 1(0.51) 197 0(0.00) 197 0(0.00) 197 2(1.02) 197 2(1.02) 197 . 9(4.57) 190 8(4.81) 190 8(4.21) 197 4(2.03) 190 12(6.32) . 197 2(1.02) , J \ Not Exposed n f (^Abnormal) 161 0(-0.00) 154 4( 2.60) 161 5( 3.11) 160 1( 0.63) 160 7( 4.38) 154 5( 3.25) 160 1( 0.63) 160 0( 0.00) 160 0( 0.00) I6i 0( 0.00) 161 7( 4.35) 161 18(11.18) 154 3( 1.95) 154 5(3.25) 161 . 3( 1.86) 154 4( 2.60) 161 2( 1.24) Questionable . Exposure n #(%Abnormal) f V 49 46 49 49 49 47 49 49 49 49 48 49 47 46 49 . 47 48 2( 4.08) . 2( 4.35) 1( 2.04) 3( 6.12) . 2( 4.08)-' 3(' 6.38) ' 0( 0.00) 0( 0.00) 0( 0.00>0( *,;00) . 1( 2.08) 6(12.24) 1( 2.13) K' 2.17) . 1( 2.04) . 0( 0.00) - o( o-.poj- 237E 13 -72- tV. Sodium Potassium Chloride G-glutamyl transpeptidase Thyroxine binding globulins CBC VJBC RBC HGB HCT KCHC3 HCH HCV 1 Differential Poly Lymph Mono Eos Baso ; TABLE 33 CONTINUED CLINICAL LABORATORY FINDINGS EXPOSURE STATUS * 4 Exposed !' ! 1Not Exposed n T W b n o r m a l ) ; ;. n #(%Abnormal) 197 2( 1.02) 190 2( 1.05) 197 1( Ov51) 197 8(4.06) 198 51(25.76) 197 7( 3.55) 197 0( 0.00) 197 IS( 7.61) 197 25(12.69) 197 67(34.01) 197 23(11.60) 197 79(40.10) I1 161 : 154 ':! 160 '; 161 , 2( 1.24) 0(0.00) 3( 1.08) 6( 3.73) ; f 161 53(32.92) : *j j 160 7( 4.38) ' :{ 160 1( 0.63) ! 160 10( 6.25) 160 17(10.63) 'V 160 I 160 30(18.75) 13( 0.13) t *J*'<, >60 . 49(30.63) ,1* 197 4( 2.03) ' 1 160 3( 1.88) 197 5( 2.54) i 160 ' 2( 1.25) 197 K . 5 U : 'j; . 159 2{ 1.26) 197 3( 1.52) i 160 3( 1.88) 197 0( 0.00) : i 160 t< *: 1( 0.63) QuestlpnaD)^^^.. Exposure ' \ A\ n ((^Abnormal J 4 9 0( 0.00) 4 47 K `:i3j 49 0( 0.00) ' 49 6(12.24 J ' 49 16(32.65) * 49 49 . 49 49 49 49 1( 2.04) 0( 0.00) 3( 6.12) 11(22.45) 14(28.57) 7(14.29) 20(40.02) 49 1{ 2.0-4).. ... 49 0( 0.00).' 49 of.o) 49 0( 0.00) 49 0( 0.00) <'* ' Urinalysis Acetone Albumin Bacteria Blood U) Epithelial Cells . Glucose White Blood Cells V TABLE 33 CONTINUED CLINICAL LABORATORY FINDINGS I vs.` EXPOSURE STATUS i Exposed n # (Positive) * Not Exposed n #(%Positive) i- 196 o( o;oo) i 159 1( 0.63) 196 2(-1.02) j i 159 0( 0.00) 196 11( 5^:61) , : 159 13( 8.18) 196 2( 1.02) j 159 2(; 1.26) 196 68(3^.69) ' 159 44(27.67) 196 2( 1.02) | ! 159 2( 1.26) 196 3( 1.53) | . 159 4( 2.52) 1 0.05 < p < 0.10 for exposed vs. not exposed * 0.01 <p<0.05 for exposed vs. not exposed ^ 0.001< p <0.01 for exposed vs. not exposed Exposure n ~7(%Posi tive) v 49 0( O.OO) 49 0( 0.00) 49 0( 0.00) 49 0( 0.00) 49 12(24.39) 49 0( 0.00) 49 2( 4.08) T2JLCZ I '" * BLOOD Calcium Phosphorus BUN Creatinine Uric Acid* Glucose (CS) Total Protein Albumin Globulin Albumin/Globulln ratio Total Bilirubin Direct Bilirubin Transaminase, SGO Transaminase, SGP Alkaline Phosphatase LDH Iron Sodium 1 TABLE 34 t r < '' . CL,INICAL LABORATOiRY FINDINGS iVS CHLORACNE STATUS IN EXPOSED. ONLY li History Only n #(%Abnormal) 69 0( 0.00") 69 0( 0.00) 69 , 4( 5.80) 69 U 1.45) 69 K 1.45). 66 6( 9.09) 69 1( 1.45) 69 0( 0.00) 69 0( 0.00) 69 0( 0.0,0).. 69 2( 2.90) 69 4( 5.80) 66 5( '58) ; 66 5( 7.58) 69 . 1( 1.45) 66 - 3( 4.55) 69 & 0( 0.00) 69 0( 0.00)f I I' :j n i 1J "tt, '1 1 Current_ "#(%Ab"normal) 102 0( 0.00) 98 1( 1.02) 102 4( 3.92) toi 1( 0.99) M 2 7( 6.86) 98 7( 7.14) 102 : 0( 0.00) 102 ` 0( 0.00) 102 0( 0.00) w 2( 1.96) 102 0( 0.00) 102 51 4.90) 193. 2( 2.04) } 98 2( 2.04) 102 3( 2.94) \ 98 8( 8.16) 102 21 1.96) h 02 2( 1.96) No History ft tf(XAbnormal) 26 0( 0.00) 26 2( 7.69) -. 26 0( 0.00) 26 0( 0.00) 26 4(15.38) 26 1( 3.85) 26 0{ 0.00). 26 0( 0.00) ' 26 0( 0.00) 26 0( 0.00) 26 0( 0.00) 26 0( 0.00) 26 1 (. 3.85) 26 1( 3.85) 26 0( 0.00) . 26 1( 3.8)' 26 0( 0.00). 26 0( 0.00) ,V t' ; "i -..ft n'. TABLE 34 (ONTl(4UEO :, 'CLINICAL LABOttAflr FINOINQS i,; r ' . v CHLRACNE STATUS 'itfjEXPOSEO ONLY' i.f-rvv L ".' - kyLSfi I-. `V History* Only;* * n ' i(Abnormal Potassium Chloride G-glutamyl transpeptidase Thyroxine binding globulins . 66 it i M t 69( ,,i o( o.oo);' 69 2( 2.90)/ 69 16(23.19) CBC UBC RBC HGB HCT MCHC HCH HCV Differential Poly L>mph Hono Eos Baso r j'.i -v ' ' 69 1( 1.45) 69 0( 0.00) 69... 169 - 10(14.49) . 69 30(43.48) `69 6( 8.70) .* '69 V, 69 27(39.13) . *i., t1' 2( 2.90) 69 4( 5.00) 69 0( 0.00) /. ,V 69. .,,.I 1( l1. ^ ^'S-; J6 9 U 6(0.0^);; ^ffX A bnorm al) o( o.do) U 0.98) . 5( 4.90) ' 27(26.47) ;"JLOI 6( 5.94) 0( 0.00) 7( 6.93) 12(11.88) 32(31.68) w (i3.B 6) 4 5 (4 4 .5 5 ) k' 2( ,1 .9 8 ) 1( 0.99) 1( 0 .9 9 ) 1( 0 .9 9 ) 1;0( 0 .0 0 ) .vri - I ' V , ':-"A>*' 3 vvn ^ -r:t f(X A bnorm al)L.a^fiS 26 26 26 27 27 27 27 27 27 27 27 h ;?.?> : / M f . l(;3 i8 5 f 8(29.63) . .. /* * ,;. ftri : 3^ v J, ; . , rtf , \ ** 'v . 0 ( .O) , ^ . v o( .'o) 3 (1 1 .1 1 ) 3 (llv ll) 5 ( 1 8 '.5 2 ) 3(11.11) UV\ rf'7 (2 5 .9 3 ) .j ' I. V * 27 0 ( 0 .0 0 ) . 27 0 ( 0 .0 0 ) V;. 27 < & > > 27 27 o ( l o . o o ) ' / ; y S TABLE 34 CONTINUED CLINICAL LABORATORY FINDINGS : vs, 1' CHLORACNE STATUS TN EXPOSED ONLY Urinalysis Acetone Albumin Bacteria Blood Epithelial Cells Glucose White Blood Cells History Only n lUPositlve) 'V i 68 0( O.OO) 68 0( 0.00) 68 5( 7.3S) 68 1( 1.47) 68 26(30.24) 68 2( 2.94) 68 1( 1.47) Current n l(3Positive) 101 0( 0.00) 101 1( 0.99) 101 2( 1.90) 101 1( 0.99) 101 36(35.64) 101 0( 0.00) 101 2( 1.90) * 0.01< p<0.05 for history only vs. current vs. no history V No History . n KXPosi tlve) 27 0( 0.00) 27 1( J.70) 27 4(14.81) 27 0 ( 0 . 0 0 ) 27 6 ( 2 2 . 2 2 ) ' / 27 0 ( 0.00} 27 0( 0.00) -76- 237817 i I .TABLE 35 ' %J * ' i -' 0 . i -% 7;* - i *- EXPOSED (n=l97) . URINE COPROPORPHYRIA s Low (<30 mcg/1) Normal *; Man (30-240 itg/l). ' (>240 mcg/l) i '% - # *# % a 6 3*05* 185 *93.91 6 3.05 QUESTIONABLY EXPOSED (n=49) '* 0 0.00 . 48 97.96 1 2.04 NOT EXPOSED (n=161) 1 0.62 154 95.65 6 3.73 p * ns for comparison of exposed to not exposed. . URINE UROPORPHYRINS ... -- -- EXPOSED (n=196) QUESTIONABLY EXPOSED (n=49) NOT EXPOSED (n=161) Low (<15 mcg/1) # m 8 -X 4.08 2 4.08 6 3.73 Normal (IS-fiO-iricg/T) " #X High ~~(>60 mcg/1)" #% 140 71.43 48 24.49 42 85.71. 5 10.20 122 75.78 33 20.50 p * ns for comparison of exposed to not exposed. * The values for coproporphyrin and uroporphyrin were from a single void sampl -77- 237E19 f V NERVE PARAMETER Ulnar IVJ 00 Peroneal Nerve Conduction Velocity Latency Amplitude Ratio Nerve Conduction Velocity Latency Amplitude Ratio Sural r. Nerve Conduction Vel o d t y Latency Ampl 1tude TABLE i36 MEAN NERVE'CONDUCTION PARAMETER VALUES FOR THE THREE EXPOSURE CATEGORIES (Not Adjusted for Age) ! -:| .. . EXPOSED x + s (n) % 1. h' ! I i. 56.90 + 7 , 4 3 (9) 3.30 .1.08 (9) f NOT EXPOSEO ; ' x + s (n) 1 - .) \ 60.07 + 8.44 (10) j 3.07 + 0.68 ( 9) 1.04 + 0 . 1 8 (9) j 1. J !" '* i- 0,91 + 0,19 (10) 41.08 + 5.63 (160) j 1i 4.07 +1.21- (160) j 43.45 + 5 . 9 6 4.12 + 1.04 (134) (134) 0.86 + 0 , 2 3 (160) j i i! ;i !. 0.92 + 0.16 (134) 41.27 + 6.50 (i s o ) j 4.84 + 0.59 (.150)' 1 1.91 + 1 . 0 7 so) ; 42.42 + 4.97 (128) 4.62 + 0 . 6 8 (128) 2.51 +1.31 (128) QUESTIONABLE EXPOSURE .? x + s (n) 'V-., , * .ifv * V v- ' 52.12 + 1 . 5 3 (2) 2.55 +0.11 (2) 1.01 + 0 . 1 2 (2) i / ; 42.55 + 5.16 (42) . 4.31 + 1.18 (42) 0.93 + 0.16 (42) 40.90 + 4.41 (41) 4.63 + 0 . 5 9 (41) 2.07 + 1.06 (41) m. NERVE Ulnar I tIo Peroneal Sural PARAMETER Nerve Conduction Velocity Latency- Amplitude Ratio Nerve Conduction Velocity Latency Amplitude Ratio Nerve Conduction Velocity Latency Ampl1tude . * . -ii TABLE 37 MEAN NERVE CONDUCTION PARAMETER VALUES FOR THE TWO EXPOSURE CATEGORIES (Adjusted:for Age) ** i EXPOSED x + s (n) t i; -0.14 + 0.92 (9)1 ' NOT EXPOSED x + s (n) 0.26 + 1.13 (10) 0.2,0 + 1.18' (9)i -0.13 + 0.94 (9) 0.35 + 0.95; (?)j -0.35 + 1 . 0 5 (10) 1? ti ' i \ '^f -0.06 + 0 . 9 1 (160) 0.04 + 1 . 0 7 (134) -0.09 + 1.05 (160) ' 5f -0.10 + 1.15 (160) 111 . 1i i 0.06 + 1.17 <*?'? s. (150) 0.06 + 0.92 (134) 0.05 + 0.83 (134) -0.04 + 0 . 8 5 (128) 0.11 + 0.95 (150) -0.06 + 1.07 (128) -0.07 + 0.911 (150) 0 . 0 9 + 1 . 0 9 (128) ii ( j 1 10/ * ' t\ ns , ns ns 'j * ` ns ns ns ns ns : ns V NERVE PARAMETER Ulnar NCV Latency Peroneal NCV Latency Sural NCV TABlt 33 EXPOSURE VS. OUT-OF-RANGE NERVE CONDUCTION PAfR.AMETER VALUES (Not Aidjusted for Age) (n) (9) * (9) (160) (160) (150) ip EXPOSED Low Normal (X) (X) 1 (11.11) 0 T (77.78) 6 (66.67) 119 (74,38) 98 (61.25) 41 (25.63) 51 (31.88) 105 35 (70.00) (23.33) High (X) 1 (11.11) ' 3l (33.33) r ) * o 1l' (. 1 11 l1. (6.88) {; I ; 10 i (6.67) (") (10) (9) NOT EXPOSED Low Normal (X) (X) High v < 1 (10.00) 0 7 (70.00) 7 2 (20.00) 2 (77.78) (22.22) (134) 65' (48.51) (134) 78 (5.21) 68 (50.75) 49 (36.57) 1 (0.75) 7 (5.22) (128) 76 . 44 (59,38) (34.38) 8 (6.25) 1r 1... . 't r*i * ' ,^ , * as ns 0.0001 ns * 41S. ' Exposed group has a higher percentage with low Peroneal Nerve Conduction Velocity than the Not Exposed group. This may, however, be an artifact of age, since. NCV slows with age and the Exposed group 'Is older than" the Not Exposed group. *80- 7 # Pregnancies * f Live Births I Dead 1n 4 Weeks Rate (/1000 live births) t *\1 EXPOSURE v i VS.i REPRODUCTIVE! 'FINDINGS Exposed Tn-1897 663 n* |3 Not Exposed (n=155) ti l 429 573 % 1 37} 16 27.92 !i ; 10.767 Probability > N.S. I Miscarriages Rate (/1000 pregnancies) 72 *;. 108.597 # Children with Birth Defects* Rate (/1000 live births) \ V 1 Stillbirths Rate (/1000 Fetuses to term) 23 40.140 14 23.050 51 118.881 t 20 I 53.619 5 13.228 N.S. * N.S. .. * N.S. * These are further detailed in the Summary of Birth Defects which follow Questionably;: * EX si8*^9) 139 128 3 23.4375 7 50.360 6 46.875 - j10 4 30.303 ' 237822 iIi! EXPOSURE CATEGORY: * TAd . '40 SUMMARY OF BIRTH OEFECTS AS REPORTED B;Y SUBJECTS t EXPOSED il i QUESTIONABLY EXPOSED / *' w *,f NOT EXPOSEtT'" TOTAL PREGNANCY BEFORE OR AFTER SUBJECTS' EXPOSURE: LIKELY BIRTH DEFECTS: Before 8a After 6b Unable -to Determiin,e j ii 2e i Before 2d Unable to After Determine 3e -- mwm ** n f 32 POSSIBLE BIRTH DEFECTS:9 (Insufficient data to determine severity or cause) 1 ' .5 . i 1 i ---- 9 17 UNLIKELY BIRTH DEFECTS:** CrliOo 1 1 . r '" \- 1 69 Subjects' descriptions of Birth Defects were reviewed with faculty at the Cincinnati Center for Developmental Disorders and categorized as Likely Birth Defects Possible Birth Defects and Unlikely Birth Defects. includes: ^Includes: includes: ^Includes: e Includes: ^Includes: ^Includes: ^Includes: Congenital cyanotic cardiac anomaly, hydrocoele hernia, undescended testicle, angioma, congenital short leg, club foot, anomaly of sternum. Pectus carlnaturn, obstructive defects of urinary tract, Down's Syndrome, congenital hydrocoele, spina bifida. \' Unspecified cardiac anomaly, pyloric stenosis. Hydrocephalus, congenital anomaly of eye. -j Ventricular-septal defect, atrial-septal defect, club foot. Spina bifida, club foot, Down's Syndrome, obstructive .defects of urinary tract, hernia, antral web, congenital anomalies of eye, absence of finders, cystic hygroma, polycystic k'ldney disease (auto somal dominant with positive family history), congenital dislocation of hips (two of two children in one family; one male, one female). . < Epilepsy, retardation, slow learner, deafness, Incomplete ossification of vertebra. Muscle problems, one eye larger than other,'tongue-tied, speech defect, punctured lungs, Inherited arthritis, blood problem, floating kidney. ; 23782J ACKNOWLEDGEMENT The study which is reported here received support from: THE MONSANTO COMPANY THE NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES, U.S. PUBLIC HEALTH SERVICE THE INSTITUTE OF.ENVIRONMENTAL HEALTH, UNIVERSITY 'OF CINCINNATI........ ~ " ..... . i 237S24 ' x UNIVERSITY OF CINCINNATI DEPARTMENT OF ENVIRONMENTAL HEALTH 2 ,4 ,5-t w o r k e r s ' S t u d y INFORMED CONSENT STATEMENT Before 'agreeing to^pirticipate in this study, it is important.that you understand. the_pdfpbse* of the examination, its benefits and possible. discomforts. The objective of this thorough examination is to determine the health status of the employees and former employees of the Monsanto Industrial Chemical Company in Nitro, West Virginia and to identify health problems which may be related to the occupational environment. The examination will focus on possible health effects over a long period of time of chemicals associated with the making of 2,4,5-T such as dioxin. If __________________________________________________ , agree to participate . in the medical research study conducted by the University of Cincinnati under the direction of Dr. Raymond R. .Suskind. I understand that'l^will be interviewed and asked a series of questions about myself and the health of my family, in addition to a physical examination I shall permit chest X-rays and an EKG to be done; shal1.permit pulmonary function and nerve conduction tests to be performed; shall have blood drawn and furnish urine for laboratory examination. If indicated by the physician's examination, skin biopsies and skin scrapings for laboratory diagnosis will "be" done; -ahe'"di scomfort of -the biopsy wiTl -be -the same, as -with a..ski n_ _ ; x :.. injection.. M The University of Cincinnati Medical Center follows*a policy of making all decisions concerning compensation and medical treatment for injuries occurring during or caused by participation in biomedical or behavioral research on an individual basis. If I believe I have been injured as a result of research, I will contact Dr. Suskind. Any questions- that I may have concerning this study will be answered by Dr. Raymond R. Suskjnd, phone.(513) 872-5701, or his associates. I am free to withdraw froar.this study at any tifne. Subject __ Investigator Witness ____ Date 237S25 'HEALTH STATUS RESEAP.CH PROGRAM - UNIVERSITY OF CINCINNATI LOYES OF THE MONSANTO INDUSTRIAL CHEMICAL COMPANY QUESTIONNAIRE Name: Last * First Address: Street City State . Telephone Number: / area code Social Security Number: / /- (5) Present Status| /__/ Active (1) (check one) \ _ j Retired (2) __/ Terminated(3) '6-10) Current Department: -(11-14) Job Title: (15-17) Clock Number: //// Middle Apt. 4 Zip Code #/ / / / i* ! #/ / j j 237826 t\ r rcnui a i I) 3. Race: /___ / White, not of Hispanic Origin(1) ___/ Black, not of Hispanic Origin (2) /___/ Hispanic (3) L J American Indian or Alaskan Native (4) l ___f Asian or Pacific Islander (5) / 7 Other______________________ ' (6) ) 4. ^Marital Status: /__/ single (1)* /__/ married (2) /__/ divorced (3) . / / aeparated..C4) L . widowed 151, 3b/ 5. Numper of Marriages: /__/ 6-37) 6. Education: Highesi'ffiade completed / / / ' Elementary * 01 - 08 Secondary - 09 - 12 * College =* 13 (1 year) 14 (2 years) 15 (3 years) 16 (4 years) 17 (5 years) 18 (6 years 19 (7 or more years) ArrutuiA i B. OCCUPATI^ItMClSTORY 1. Ar you X ed ^t Monsanto, Nitro? /__ / yes (1) A <i5-5) If do -(Be-of retirement I I I I I I TM mo. day of termination / ./ / I I I mo. day I IJ yr. III yr. /__ / no (2) 2. * If presently~empioyed at Monsanto 1-54) 5-59) What is your job title: Name of department:____ What is your main job or work:(describe)_ code/ I I I code/ f i l l / 60-65) When did you start this job:' I I I 9-80)/ 0 / 1 / mo. I I /III day- yr. 3. Beginning with your first job at Monsanto, give the following information: Department v -O'l* Job Title Dates (fron/to) . ... mq/yr/mo/yr What you did (work description) 7 / / / / / f V 7 i - -- *-30) 21 .- .- - - 7 / J-J-l / . ... -- / / / / l / l l !N 9-55) 3l,. f-J / / L /// (/lf!/ fi-72) 4, -80) 7 2/ / / / /)/l f!/ 1. _ 7 7 7-7 / /. I I _J-7.7 7 / / // /I ! f/ -38) 6.. / / /-/ / / / I 71. /I/// l!/ / / /-/ / ! / _ L _z_ I J / / / J *-B0) )/ 3 / If terminated or retired, list same information above. 237828 a Department 8, y / / !1 7 V2-38) 9. 1 % / ,v ' Jot) H tl e 4/* ^" t- 7. 7 / / * m/(forDo//yam.rt/e-m/s/too-//)>. T/ * 7 / LJLL / 7V**- / /- / n.55) 10. / / /-/ / / / / / / t I ..y / .72) 11. 92!-810)/) , 12. , / / / II / /7 / -33) 13. /_ / / / -/ / / / / / / /-/ / / / / /- / / j .-4 / / y-/ / f / / / / / // / / / *>=-> 14. /_ / /- / / / / / / / / // / / / -72) _15.~....... -- ------ - - --- / / /-7 / L-L. / / / / / / / / -80) What you did(work'descn'otion) " 237629 APPENDIX I ^^ * 4. If retired-o f -terminated, what work have you done since leaving Monsanto? f -3 Employ! SB Jb Title 161 ' j - 2a) \ ------ * / - / ,,>'* J-40) / ____ 1-52) / * 3-64) / Dates (from/to )_ mo/yr/mo/yr . /- /- / / / Work description S.T.C. - / ... / / / / / i- / _ //"/// / ///// / _______ . I t i l i / Itili 5-76) 3-805/0/4/ 5-16) / / 7-28) . / 29-40) / >1-52) / r " ^ - ..... .. ..... / [65-/61 79-80)/ / / - " - / * // / -_/ // // / -._ _ / // // ~ Itili itili U til _ _ Ititi __ f i l l i Ititi tini .... 5-16} # 5. Previous work history^ before Monsanto Employer Job Title Dates(from/to) mo/yr/mo/yr ~/ / t7-2d) 29-40) 11-52) 53-64) 65-76) '*-80)/ o 7 T 7 5-16) 8) / /* / / / / / / / / / / / i Work description S.I.C. / ////./ / fitti / Itili / Ititi / filli / fitti / Itti! / _______ ___ ! ! ! ! ! 237830 Employer /' Job Title -80)/ / / 6) ________________ / - 28) ______________ / Dates (from/to). \ mo/yr/mo/yr ' ^ ^ * t\ Work description i /: /- / /- / // // S.I.C. ///// ///// ///.-// ///// -t i l l ! !!!!! 6. While working at Monsanto were you engaged in other employment? ) a. mechanical work / / yes (1) / / no (2) 1) b. farming /__/ yes (1) / / no (2) ; c. other /__/ yes(l) /__/ no(2) (describe) *] r - 7.-- I n - p r e v i o u s ; , e m p l o y m e n t , e x p o s e d to dust, solvents* pesticides, welding, or sol dering fumes, ferti 1izer, weed "ki 11ers, etc.* f t y es"(1) ` / / no(2) - -... If-yeSr specify.. ^ ___ . . _ .... ___________ '" ~ 237631 c. WORK HYGIENE AT MONSANTO 1. Do iotrofcld you smoke at worksite? /_/ yes(l) _/ nol2) ). 4.) 2. Do w u oraoid you eat at worksite? /_/ yes(lj /_/ no(2) ) or drjfqk feverages such as- coffee or soft drinks at worksite? / J yes(l) / / r 3. Do you or ^tdryoiT'wear any of the following most of the time at work? ') /___ / yes(l) /__ / no(2) Short sleeves ') l ____/ yes(l) /__ / no(2) Long sleeves ) /___ / yes(l) /__/ no(2) Gloves If yes, on what job?______________________________ What kind (cotton, rubber, leather, plastic, lined, etc)? >9 ) /_/ yes(l) /__ / no(2) Protective sleeves If yes bn what job? _____ What kind (cotton, rubber, etc.)?_________________________ _ *0) j _/ yes(l) /__ / no(2) Apron If yes, on what job?_____________________________________ . What kind?________________________________ i , /, / y e s U L / / .no(2) Special Shoes or Boots If yes, do you or did you change out of them before going home? /__/ yes 7 / no 2) /__/ yes(l) /__/ no(2) Respirator "If yes, on what job? --- ----- - - - ` 43) /_/ yes(l) /__ / no(2) Eye Protection Ifyes, on whatjob?___________________________ . A) /__/ yes(l) /__/ no(2) Mask * If yes, on what job?__________________________ . _______ 15) /__/ :yes(l) /__/ no(2) Protective clothing If yes, on what job?______._______________ What kind?<_______________________________;______________________ ` 16) L _/ yes(l) /__ / no(2)v Gther (specify)_________________________________________________ If yes, on what job?___________________________________________ 47) 4. Do you or did you use a 'barrier or protective creams at work? /__ / yes11) /__/ n A8) If yes, /__/ often(l) /__ / occasionally(2) /__/ seldom(3) If yes, what brand?__________________________ 5. Do you or did you change out of your work clothes regularly before going home? i __/ yes(l) /__/ no(2) ) 6. Do you or did you change out of your work shoes regularly before going home? L J yesil) / / no(2) 237832 nrruiuiA t 7. Where 'ouc work clothes laundered? *. 1 LJf * 11 / / comnercial laundry(2) /._/ company(3.) >2) 8. D o % o u did you shower before going home? /__/ yes(l) /__/ no(2) 3) 9. Do |)fq. or^did you use waterless hand cleaner? /__/ yesll) /` / nnf 01 54) 10. Was soap silpp-T'fSff by the company? /__/ yes(l) / J no(2) What type?_________ 15) Was soap supplfed by self? /__/ yes(l) /__/ no(2) What type?_________________ 11. Did you ever develop an illness which you believed to be related to your work at Monsanto? 56) I __/ yes(l) /__/ no(2) If yes, describe briefly_______________________________ 7-61) -651 6M9) \ ,0)- 5/ What job were you engaged in at the time? Department______________________ Code / / / / / / Type of work_______ ;_____________ Code I I t ! Date of onset I I I I I I ' 1 237833 li :9) aaoi)) ;i2) :i3) (14) (15) (16) (17) (18) (19) (20) (21) (22) [23) (24) (27) (28) (29) (30) (31) 132) (33) (34) (35) ) 39) (40) D. NUTRITION . 1. How jmany days a wekL.do.*iy'oii eat; (fill in) Ul* rm- -- f-day. mal V, rerving meal? d ^ d i ^ S g the evening or night? 2. Hov^iparSltimes,,per .week do you eat the following? \\ j * Heat a'nd.Heat.iSifbstitutes (fill-in) a. Bacon ______ b. Tongue ______ , c. Sausage ______ d. Luncheon meat ______ e. Hot dogs ______ f. Liver-chicken ______ g. Liver-other ______ h. Poultry ______ i. Salt pork j_____ w j. Pork or h a m ______ k. Bones, (neck or otner) ______ l. Meat in mixtures (such as stews, casseroles, pies, etc.) m. Beef or veal ______ n. Other meat______ o. F i s h _____ _ . p- Eggs ______ q, Dried beans or pea dishes ______ r. Peanut butter or nuts ... ~ - 3. Do you use*any of the following? (circle) a. vitamin supplement . (1) b. mineral supplement (2) c. both vitamins and mineral supplements (3) d. none of-the above (4) 4. How many times per week do you eat the following? Fruit and'VegetabJles (fill-in) a. b. c. d. e. Other cooked vegetables 5. How'many times per week do you eat the following? a. b. c. d. e. f. g. Wine h. Whiskey, vodka, rum, scotch, gin 237834 A4PPENDIX I 1) 1. Do du present! y^fhoke cigarettes? /__/ yes(l) /__/ no(2) --j* * (48-43) If yes: 'at~wfiat age did you start? I l l (44-45) total years smoking? I l l 146) packs smoked per day? /__/<1(1) /__/1-2(2) I __/2-3(3) /__ />3(4] Z. (47) (48- 49) (50-51) (52) If you do not now smoke cigarettes, have you smoked them in the past? /__! yes(l) i __/ no(2J If yes: at what age did you start? I l l total years smoked? I l l packs smoked a day? /__/<!(!) /__/1-2(2) / /2-3(3) / />3(4) 3. Have you smoked as many as 5 packs-of cigarettes during your life? (53) J yes(l) L J no(2) 237835 f. ; ALCOHflt- COMSUMPTTQ^'' ^ 1. Do^you-^itfFi^^l.cehilic beverages? / -/.yes(l) /__/' no(2j S-. 56-57 J 58-^9 J 60) If n O t ^ j d y p u ever drink alcoholic beverages'? /__/.yes(l) [___f na(2) \ 4ioliol Ser?you* when you gave up drinking? I l l ^ ;> 2. H o w m d were you when you first started drinking? I l l ` " --- ' i 3. About how often do you drink some kind of alcoholic beverage? (check one) /__/ almost every day --^ (1) /___/three or four time a week (2) /___I once or twice a week (3) /___f once or twice a month (4) l ___/less, than once a month (5) When you drink beer, abotit how many cans or bottles of beer do you usually drink 51) 4_/0(l) /._/1-2(2) / /3-4(3) /__/5-6(4) / />6(5) 5. When you drink wine, about how many glasses of wine do you usually drink? " ...41/0(1) / "71-2(2) > 7" /?-4(3) ' _/5-6(4).. [ _ J > 6(5)` * " ` "--- __ 6. When, you drink-highballs, mixed-drinks, or other kinds, of-- liquor., about how rpany drinks do you usually have? --- . Z_/0(1). Z__ ^1-2(2) Z__/3-4(3) l __/5-6(4) Z_/>6(5) M J Have your drinking habits changed over time? /__/ yes(l) /__I no(2) Si-Gflr) If? w I-*f- you reduced y*q'y^r alcohol intake, indicate year? 19/ / / x-* %. V(hen you drank beer, about how many cans or bottles did you usually drink? 471-2(1) /_/3--4(2) * /___/5-6(3) /__/>6(4) 1fh_. When .you.tfrank wine, about how many glasses did you usually drink? m. 4_/l-2(l) /_/3-4 (2) /___/5-6(3) / />6(4J l}j When you drank highballs, mixed drinks, or other kinds of liquor, how many '4?d you usually have? lVl-2(l) Z__/3-4{2) _/5-6(3) /_/>6(4) til/1 237836 APPENDIX I 6. FAMILY S T Have,m t b ^ o u r father; your mother, or any of your brothers or sisters . brothers and half-sisters) had any of the following problems? READ- PB03tEM. ,, CHECK A "YES" OR "NO" RESPONSE.. IF "YES", CHECK : THE WPRCiPMATE REtATIONSHIP(S). IF'"YES" FOR A BROTHER OR SISTER, ASK: How many of your brother(s) or sister(s) have (had) this problem? AND ENTER APPROPRIATE RESPONSE. PROBLEM RESPONSE RELATIONSHIP HOW MANY SIBLINGS HAVE (HAO) THIS PR03LEH (5) (6-9) (10-11) 1. Asthma / / yes L J n /__/ Father /__/ Mother l __f Brother l __/ Sister LJ LJ H 2 ) 2 . Hayfever G - 161 v -18) -- --- * "* / / yes .. . . . . L J -- / / Father /__/ Mother /__/ Brother / / Sister ______LLJ J . .............. . ........... (19) (20-23) (4-25) 3. Acne (pimples) ' / / yes / / no* ___ - (26) 4. Eczema (27-30) (31-32) _ / yes - L J : / / Fattier /__f Mother /__/ Brother /__/ Sister * l __/ Father ^__/ Mother ^__f Brother / / Sister !_ ! LJ ..* LJ LJ (33) 5. Hives <34-37) : (38-39) - l __/ yes L J no / / Father / / Mother /__/ Brother /__^ Sister LJ LJ 237837 AHHtnuiA i PROBLEM H 6. Stomach , ,) PfiP P C 15-46) v| ' 3 RESPONSE y5 . y p y no ' f,. > ;47) 7. Colitis 48-51) [52-53) - . :c - L j y es i _ J no y RELATIONSHIP /__/ Father . 1 __/ Mother . / / Brother / __/ Sister * /__/ Father /__/ Mother /__/ Brother ^__/ Sister '54) 8. Heart attack .55-58) or angina before age 60 (59-60) . /__/ yes /__/ no (61) 9. Heart attack (62-65) or angina after age 60 1. _ 67). V__/ yes /__f no ........ /__/ Father /__/ Mother __/ Brother /__/ Sister /__/ Father /__/ Mother /__/ Brother /__/ Sister (68) 10. (69-72) (73-74) (79-80) /0/8/ (5) 11. (6-9) (10-11) High blood ;..: / / yes pressure ~ L J no. Stroke * L J yes L J no . (12) 12. (13-16) (17-18) ) ,High cholesterol high // i_/ yes no triglycerides. or high blood fat /__! Father __/ Mother __ Brother / __ Sister / / Father / __ Mother _ f Brother _f Sister / __ Father f_ Mother f/ _ Brother /. / Sister HOW MANY SIBLINGS HAVE' (HAD) THIS PROBLEM V *\i *. u u * * i1'1 LJ U LJ LJ LJ - LJ LJ !_] u u V L J. U 23783S PROBLEM--- " RESPONSE' " T- ------- Ft---- ------T -- :----------(6) 14. Liir disease /* / yes (27-30$ Ji/7 (such a$~ _ .^ j J no cirrhosis, --- (31-32) hepatitis, etc.) v RELATIONSHIP l __/ Father i __ / MotherL J Brother i / Sister / ' / Father __/'pother __/ Brother l __/ Sister HOW MANY SIBLINGS HAVE (HAD) THIS PROBl - u // LJ LJ (33) 15. Nervous W-W (3B-39) Srr disorder /__/ yes LJTM /__/ Father L J Mother [___/ Brother L J Sister LJ // V40) - 16. (41-44) (45-46) Inherited disorder or disorders they were born with /__/ yes . L-- ' no /__/ Father l __/ Mother l __/ Brother L J Sister !_! LJ (47) ' 17'. Cancer" /__/ yes ! _ J Father -\ (48-51) (52-53) L J "0 . L .J Mother j___/ Brother // (54-65) ! _ J Sister IF YES TO "CANCER", SPECIFY TYPE AND SITE : LJ . 01= lymphoma 02= hodgkin's disease 03= leukemia 04= throat 05= esophagus 06= stomach 07= rectum 08= bowel 09= kidney 10= brain 11= breast 12= cervix 13= uterus 14= lung 15= skin' TYPE: j _ I / L// L I J! / / / /. 16= prostate 17= bone 18= other cancer (specify) (.66-67) 18. How many brothers or half brothers do you or did you have? I l l (67-68) 19. How many sisters or half sisters do you or did you have? I l l (79-80) imi 237833 nr r Li'^i A * PERSONAL MEDICAL HISTORY ever had any, of the-following? If yes, in what year? was it confirmed or? CONFIRMED BY DOCTOR AREA OF BODY (TYPE)' IF APPROPRIATE (5-3) (9-12) (13-16) ( 17- 20) (21-24) Acne (blackheads j^.cysts)--- L. Skin abscesses ........... 2\ Dermatitis...................3. Liver disorder....... :......4. a. hepatitis___ j .........a. . 19/ . i J _ 1.9/ 7 A 9/ / } fl.9/ / / 19/ / A ~ (25-26) (29-32) b. cirrhosis............. b. c. enlarged liver........ c. 19/ / / 19/ / (33-36) d. other d. 19/ / / (37-40) Muscle pains (area) ......... 5. (41-44) Nerve injury.................6. 19/ / / CL9/ / } (45- 4 6 ) Nervousness........... 7. (46- 52) Stomach ulcer............... 8. (53-56) Bowel trouble or colitis.... 9. ____ 19/ / / . _ 9//1 JW TT~_ (57-60) Kidney trouble (type)..... ,;10. . 19U K ; (61-64) Bladder trouble.............11. (65-68) Thyroid disease.............12. 19/ / / 19/ / k - (69-72) Other hormone problems..... 13. ((57-3-7) 6) 3one problems (type, where) .14. Arthritis (type)(79-8Q)/l/0/l5. 1 9/ / \ ! wri 19/ / / \{9-12). Hyper tens ion .................16. 19/ / / 1 f13-16) Heart attack...... V.r.17'1 (17-20) Angina........ ....."....... 18. (21-24)- Bronchitis.... ............. 19; (25-28) Recurrent infections (type) .20. (29-32) Empnysema......... ,1....____21. 19/ / / 19/ / / 19/-/-/- W TTl .19/ / k *4 -- 1-- __it _sCJJ * (33-36) Bronchial Asthma.'..... ..v ;22. (37-40) Pulmonary edema....,..... ...23. (41-44) Pneumonia.............. 24. 19/,/ A 19/ / i . . .19/ 7 ). - 1 ! - ** - 45-48) Pleurisy............ .25. -`il9/ / / (49-52) Stroke...... ............... 26. 19/ / / 1______1______________ :_________ 27. Have you ever beerwtold by a doctor that you had (or have) any type of cancer?' (53) L J yes Cl) L J no (2) j (54-55) If yes, what kind of cancer? Specify type: I I I I I I (56-57) 01= lymphoma 02= hodgkin's disease 03= leukemia 04= throat 05= esophagus 06= stomach 07= rectum 08= bowel 09= kidney 10= brain 11= breast 12= cervix 13= uterus 14= lung 15= skin 16= prostate 17= bone 18= other cancer (specify) (58-59) In what year were you first told about this (these) condition(s)? 19/ / / 19/__j (60-61) 237840 2) 26. Hav$ you ever beerhfcospitali zed? / / yesll) /__/ not2) it _ _ IF/YES, m &b b v o u h o s p i t a l i z e d ? I n ^ h a ^ e a r were you hospitalized? W h a t w a s 't h e name o f the hospital? Where, is.the".bofpital (in w h a t c i t y and st at e) ? *3-64) 65-66) 67-68) 3-70) /1t 7?) V/ 4) 79-80)/ IV 1/ CUFE'lENTS' 19/ / / 19/ / / 19/ / / 19/ / / * 19/ / ! 19/ / / ........ 237841 Mf'rc.UL/iA * .GASTROINTESTINAL (STOMACHS. INTESTINES) 29'. Hay youSlter TW^Tnore than. 10 pounds without dieting? /__/yes(lj. /__/ 9) *. -17) ) - 22) -24J i) I f L e sj^Bount lost? / / ;/ lbs. over what t'fme period? / ./' weeks ' ' If ]fes,^ve year(s): . 19/ / / 19/ / / 19/ 7 / 19/ / / 30. Have you ever, loai your appetite? /__/ yes(l) /__/ rto(2) .v If yes, when did this happen? I l l v mo. How long did this condition last: I I III yr. I weeks 31. Have you ever had a peculiar taste in your mouth: /__/ yes(l) j __/ no(2) If yes, what kind of tastetspecify)?___________________ :_________________________ 3-33) If yes, give year(s): 19/ / / 19/ / / 19/ / / 19/ / / i) 5-42) 32. Have you experienced nausea frequently? /__/ yes(l) /__/ no(2) If. yes, give year(s): 19/ / / 19/ / / 19/ / / 19/ / / 3) <v / 33. Have you ever had abdominal pains: /__/ yes(l) /__/ no(2) - If yesv Indicate location (check only-one of the-following.) :, .... A y .. /__/ diffuse(l) /__/ epigastric(2) ^__/ periumbilical(3) /__/ other(4) 5J If yes, is/was the pain related to meals? /__f yes(l) /__/ no(2) 6- 53) If yes, give year(s): 19/ / / 19/ / / 19/ / / 19/ / / 34. Have you ever experienced episodes of crampy, abdominal pain associated with S) constipation, lasting several days? / / yes(l) / / no(2) J5) If yes, have there been more than: / / 2 such incidents(l) /__/ 5 incidents(2) 6-63) If yes, give year(s): 19 / 7 / / 19/ / / 19/ / / 19/ / * NEUROLOGICAL1 4) 35. Do you often have headaches: /__/ yes(l) /__/ no(2) $5) >.If yes, how often? /__/ daily(l) /__/ weekly(2) ^__/ less frequently than weekly( 19-80)/1/2/"^7 ^T6. Have you ever had any of the following conditions? WHEN? 5-8) Sleeplessness current /__/ yes(l) /__/ no(2) past ^_/ yes(l) /__/ no(2) 19/ / / ) Nightmares. current /__/ yes(l) /__/ no(2) past /_/ yes(l) /__/ no(2) 19/ / / ... a5) Muscle pain current /__/ yes(l) /__/ no(2) past /_/ yes(1) I __! no(2) 19/ / / 17-20) Joint pain current /__/ yes{1) /__/ no(2) past /_/ yes(l) [ __/ no(2) 19/ / / 237842 APPENDI* I " .-24) i-28) (29-32) Muscle weakness in limbs -current / / yes(l) /__/ no(2J Parrfsth current /__/ yes(l)- /__/ no(2) Dizijnes current /__/ yes(l) /__/ no(2) (33-36) Depr^si current / / yes(l) /__/ no(2) Memorjr ^00?, or change in. (37-4)* memory c u r r e n t /__/ yes(l) / / no(2) (41-44) Always tired, general fatigue current / - / yes(l) / / no(2) (45-48) Nervousness current /__/ yes(l) /__/ no(2) (49-52) Sleepiness current / / yes(l) /__/ no(2) past / _ / yes(l) / / no(2) 19/ J*/ past ? /yes(l) 7 / no(.2) 19/ / past / /yes(l) / / no(2) 19/, / past /::/ yes(l) / / no(2) 19/ / * Past / /yes(l) /_/ M 2 ) 19/ / past past past / /yes(l) /_/ no(2) 19/ / / /yes(l) /_/ M 2 ) 19/ / / /yes(l) /_/ no(2) 19/ / / / z / / / / / SEXUAL HISTORY (53) (54-59) ( >62) (63-65) (66- 68) " (69-71) 37. Have you noticed any change in your sexual life? / / yes(l) / / no(2) If yes, give year(s): 19/ / / 19/ / / 19/ / / If yes, what was the change? < -Decreased sexual-desire? / / yes(l)-~ / . / nc(2)lf yes,..when?....19/ / _/.....,, Increased sexual desire? / / yes(l) / / nc(2)If yes, when? 19/ / / Decreased ability to achieve & maintain erection? /__/ yes(l) /__/ no(2) If yes, when? 19/ / / Increased ability to achieve & maintain erection? / / yes(l) __/ no(2)\ If yes, when? 19/ / / (79-80) /1/3/ '-14). J, REPRODUCTIVE HISTOrV ' How mai^ t i ^ p n a v e ^ & B been-married? /__/__/ Time(s) Pate(s4of ^ H a q e ( s ) : 19/ / / 19/ / 7 19/ / / 19/ / / ASK FOR Xtl, HrVES'fHUSDAHD'S): (Record answers in table below) J. ;Do you have7 (have you had) trouble having a family with your wife (husband) despite a desire to have one? 2, How many children^ born alive, do you have or have you had with your (present, previous, last previous, etc.) wife (husband)? . 3, How many children, born alive, died within 4 weeks of birth? 4, How many miscarriages or spontaneous abortions did your wife (did you) have? -5, How many stillbirths did your wife (did you) have? How many children, born alive, were born with a birth defect? QUESTION PRESENT SPOUSE PREVIOUS SPOUSE ( 17} 1, .- Problems having a family / / yes / ` ' (1).. " / no / (2) .-- / yes I I no .-.(1) , ...(2)- LAST PREVIOUS SPOUSE /_ / yes 1 1 n o ' (1). . . ~ ( 2 ) , _____ 2 , Children born "18-23) alive / / */ children- - / / -/children - / /- / children___ (24-29) Birthdates (mo./day/yr.) k ** 3, Children dead within 4 weeks .* // < /children / / /children / / /children (30-35) 4, Number of miscarriages 5, Number of (36-41) stillbirths /. / j /// //! Lt / L // / // (42-47) ; 6* "Children with birth defects State type of birth defects / / /children / / /children / / /children **3744 APPENDIX I MffilCAJi vcMgfeoularly Jse health aids such as those for constipation, ^i'^Mion, arthritts, or headache (for example aspirin, laxatives, diet pills, e / / no(2) If yes .whatjrffi'd or brand: Do you regularly use salves or liniments suctfryas those for itchy skin,''burns, abrasions, etc.?^ /__/ yes(l) /__/ no(2) If yes, what kind or brand:_________________ Do you have or have you ever had acne? /__/ yes(l) /__f no(2) If yes, how was it treated?_______________________________________ Are you now taking medication(s) prescribed by a doctor? / / yes(l) /__/ no(2) If yes specify the name(s) of the medications and the illness(es) being treated: ______________ Do you have any known allergic reactions3^ drugs? * / / yes(l) * /__/ no("2) IT yes, to what drugs, (be specific)?___________________________________;_______ ^7845 K. REVIEW OF SYSTEMS'.AN0 PHYSICAL EXAMINATION Vltalj'Sig.... tai-54) Nursi lOfli / (55-60) Date I I I I l l / / / ' mo. day yr. * (61-661 BP / f \ l . / p / / /nniHg. (67-69) Pulse I I I /min. (70-71) Resp. / / /mir. (72-73)' Height / / /Inched .w (74-76) Weight./- / / /pounds (79.80) 0/4/ (6} Unusual appearance /__/ yes(l) /__/ no(2) Temp. /_/_/./ /P (77-78) II) If yes, describe_________________________________________ (7-8) Physician_____________________________ Physician ID# I I I Additional History . Review of Systems Physical Examination ~ (Indicate Pro&lems and/or Abnormal Findings) ~ Skin - active or residue of acne, * "'other* skin abnormalities','nails, hair - ........... ... .. -- -- # (9-10) / _ / yes(l) / / no(2) Nose, mouth, throat, mucous membranes 1 / yes(l) ; .f / _ / no(2) (11-12) j _ _ J yes(l) j _ J n o ( Z ) Dental status / / yes(l) / _ / no(2) ... (13-14) / / yes(l) [ __/ no(2) / / yes(l) _ / no(2) 237846 Add i t i o n aV'-fffsfcrry^ -Re-v-i-'-ew?-o-T'-S-ys--t-e-m-s lyes* W4 w / i.. , S' ft. ; ** '' 1 -16) / *f yes (1) Lymph nodes /__/ no(2) ** * \ *t V Physical Examin-at"ion" w >. / . - 4, * ' A ',\ .IT / / yes(i) / / no(2) ' "* -IB) / / yes(l) / / no(2) Thorax,- Pulmonary, Cardiac . j* / / yes (1) /__/ no(2) * *j,. :"zo") / / yes(lj / / no(2)................................ Gastrointestinal / 7 yes(l) / _ / no(2) " ............................. " ".-22) /__/ yes{l) Liver L J no(2) - - 1-24) ^____ / yes(l) / / no(2) / / yes(l) / _ / no(2) /__/ yes(l) / _ / no(2) 237847 Add i History Rev-few of Systems. Sexualj - LiteWS- ****' 'm Vm *i. y [5-26) / / yes(l) it Skeletal. / / no(2) Physical Examination / / yes(l) / / no(2) - .< (27-28) /__/ yes(l) Kidney L J . n(2) *. /__/ yes(l) V / / no(2) (29-30) 1 __/ yes(l) Bladder ' / / no(2) / / yes(l) /__/ no(2) (31-32) /__f yes (1) / / no(2) Genitalia, "including additional reproductive review / / yes(l) /__/ no(2) <33-34) /__/ yes (1 j 1 / _ A no^2) / 7 yes(l) Z__/ no(2) - . - ------------------y*------ -------- 237848 Additional Hi3 terry Review, of-Systems * .4 Yascul|r' ^ El-- lsW --*U*---------- --- vj ft -JS1 t" Physical Examination .* ** ' ', % X*'.p* A * / / yes(1) /__/ no(2) Neuropsychiatrie /__/ yes(l) / / no(2) / / yes(I) Df^.ions /__/ no(2) /__/ yes(l) / / no(2) ------ ~ s * - - -- / / y.es(l) / / no(2) / / yes(l) / _ / "0(2) 237849 AKf'LfiL'iA. 1 Abnormal F * . v F^pm.-4^gary /**/ yes(I) itai /-- /" n(2 ) " .s*' From Physical Examination /__/ yes(l) Retail: /__/ no(2) IJi^gnosis - Impression . . ____________ ___ QBWWtS 237850 i 1) '44) .45) '{46) 47) 1*3) | ,45) (50) .51) (52) 53) (54) 55) I (58) (59) (60)- (51) (52) I [ (53) irI i PULMONARY' FUNCTION RECORD l- , S 1. tai%g*am1nation or visit t o ;the doctor,, have you.experienced following: Yes ; No- c. 'c h ills _ . A d. Muscle ches e. Shortness of breath f. Chest pains,Aching, tighness or burning . g. Wheezing h. Expectoration (phlegm) i. Stuffy nose j. Eyes burning or watering k. Throat sore or burning l. Loss of appetite m. Weight loss' 2 -Do--you smoke ..cigarettes, clgars.,.or_pipe?./_/ y e s (1) /__/ .no(2) 3. Have you had'any of the foTIowing recently?" ... Respiratory infection within two(2) weeks? /__/ yes(l) /__f no(2) Bronchodilator drug within six (6) hours? __/ yes(l) /__/ no(2) Cigarette within one (1) hour? / / yes(l) / / no(2) i Meal within two (2) hours? __/ yes(l) __f no(2) 4. Are you now wearing any tight garments? __/ yes(l) __/ no(2) 5. Have you had this test before? / yes(l) - / no(2) If yes, w h e n ? _ __________________ where?___________________________ under same name? __/ yes(l) /__/ no(2) 237851 APPENDIX 1 PULMONARY FUNCTION- TEST "RECORD _'/ " J" ' ..*>1 . 1 . '' 5) Room Impe C. i"^ 66) (67) TEST MOtlVAflpN-EFFORT: P o o r ______ Fan* V . (1) -- (2) RECORD: Acceptable^" . Not Acceptable (1) (2) REMARKS: _______________ , ___ ,___________ Good O)' Excellent (4). [68-69) TECHNICIAN (79-80) 71/5/ ID#/_/__/ (6-7) Total FVC Time VOLUME IN L. ATPS FEV, . FVC FHF^25*75^ (8-11) (24-27) L/Sec. VOLUME IN L. BTPS FEV/FVC PREDICTED' NORMAL % PREDICTED' (12-15) (28-31) L/Sec. (40-43) (16-17) (18-21) (22-23) (32-33) (34-37) -- (44-47) ------ ------- (38-39) -- -----, ; S.` 237852 .n e r v e Co n d u c t i o n .8-49) i # r* (50-53) (54-56)'-' ^tentiy / / ms Distance / / / mm*. (57-60)' ` N.C.V. / / /./ / m/s (61-63) Stm. Curr. / / / / mA (79-00)71/6/ (5.14) ///.// / / /./ / (15-23) / / /./ / / / /./ / (24-30) / /-/ / / /./ / 2. Peroneal (31-34) (35-37) Latency / / /./ / ms Distance / / / / mn 18-41) ... N;C.V.- -/- / - / . / A -m/s *- (,42-44) (45-54) Stm. Curr. / / / /mA .. ///.// / / /./ / (55-63) ///.// // // / (64-70) (79-80J/1/7/ T. (5-81 (s-n ) (12-15) U6-.18) (19-28) C29-37) (38-44) / A./ / / /./ / Sural / / / /Latency A. ms / / / /Distance mm I I /N.C.V. 1 . 1 m/s / / / /Stm. Curr. mA / / // / / / / . / / / 7 /_/ / / / / . / / / // / /..// / // / /_/ LJ /// LJ // /// z_/ LJ 237853 LABORATORY TESTS Pleas^che|jS[ if done:' (45-47) L J & l l W /_Ano(2J (**8-50) / /.y e 'i u . ) ' / / no(2) (51,53) A / ye$(lj ~ / / no(2) (54-56) / / yes(l) / / n&(2) (57,59) / / yes(l) (60,62) / / yes(l) / / no(2) / / no(2) (63-65) / / yes(l) /_/ no(2) (66,68) /_/ ye$U) (79-80) m OTHER TESTSi /_/ no(2) Urine Sample IOr/ / v Blood Sample 10#/ / / Skin Biopsy ID#/ / / Skin Scrapings ID.?/ / / Culture ID#/ / / Photograph ID#/ / / X-Ray ID#/ / / EKG ID#/ / COMMENTS: 237854  AW.EWJI'X II #I` Stati sticaf'.Procedure w U ... For a discussion of the methods ( x ^ test for independence, age-adjustment) used for contingency^table analysis please see Statistical Methods . for Rates and Proportions (J.L. Fleiss, Wiley Interscience (1973) New York). Fisher's i exact test is presented in Testing Statistical Hypotheses (E.L. Lehmann, John Wiley & Sons (1959) New York). A fine discussion of multiple linear regression analysis and analysis of covariance is contained in Applied Regression Analysis and Other Multivariable Methods (D.G. Kleinbaum and L.L. Kupper, Duxbury Press (1978) North Scituate, Massachusetts)- -. ............... . -- .. -- - . - - 237855 'lSfet' APPENDIX III Clinical Findings OTHERS^ \ ^ -* y Not Exposed: (n=13) Limited Motion H/0 "Nervousness"'' H/0 Depression 1 1 1 Arcus Senilis Cataracts 1 1 Retinal Nicking H/0 Thrombosed Deep Vessels H/0 Angina H/0 Hypertension 1 1 2 Rhonchi Asthma ...... .... . 1 ..... ... .... .i Poor Dental Hygeine ,,1. H/0 Duodenal Ulcer H/0 Stomach Ulcer 1 .H/0 Cholecystectomy - 1 H/O Prostatitis H/U Renal Surgery 1 H/0 Thyroid Disease H/0 Tumors (Breast, Uterus,tJone) 1 Arthritis(Heberden's Nodes) H/U Chloracne Chloracne Actinic Elastosis H/0 Acne Vulgaris Acne Vulgaris Hirsutism Seborrheic Dermatitis 2 4 3 1 'Exposed `(11=5) 1 1 1 1 1 -T... ... . . -- 1 1 1 1 4 3 4 1 237856 Clinical Findings OTHERS "Dishydrotic- Dermatitis" Not Exposed ni=T3T Lichen Planus s Hypopigmentation, post inflammatory 1 Seborrheic Keratoses 1 Actinic Keratoses 1 Dermatophytosis 2 Onychomycosis 1 Baker's Cyst Decreased Growth of Hair -* 1 Nevi 2 Dermatofibroma 1 Exposed TnSfr 1 1 1 .3 1 1 237857 ' APPENDIX IV CLINICAL.FINDINGS i * NOT . (n=163) frv=204) QUESTIONABLE TiT=si} #% #t #X NEUROLOGIC . Clonus Hyporeflexia and Hyperreflexia 5 3.07 1 0.49 5 2.45 - Positive Babinski/Romberg - 2 0.98 - Loss of Vibratory Sensation, Light Touch, and Proprioception Paresthesia-Numbness Resting Tremor Head, Hand Speech' Dysfunction H/0 Multiple Sclerosis H/O Cerebrovascular Accident H/0 Epilepsy ----- PSYCHOSOCIAL -- ----- -------- -- H/0 "Nervousness" H/0 Depression H/0 Anxiety H/0 Decreased Libido H/0 Increased Libido H/0 Impotence, NOS 9 5.52 14 6.86 1 0.61 3 1.84 1 0.61 6 2.94 4 * 1.96 - 1 1 ~z 1 --.6-0.61 4.23 ~ - - Z r 94^_:-- - ....1 0.61 - ------- --- 16 3 - 12 2 4 ------ - ..... - - - - - - 9.82 1.84 7.36 1.23 2.45 - 27 6 -1 38 .17 . 13.24 2.94 0.49 18.63 8.33 5 1 9 2 " - 1.96 - 1.96 9.80 1.96 17.65 - 3.92 EYE Pterygium Macular Degeneration Arcus Senilis' Cataract Diabetic Retinopathy Exotropia, NOS H/0 Cataract Surgery H/0 Glaucoma 2 1.23 4 2.45 2 1.23 1 0.61 1 0.61 2 1 6 3 - 1 0.98 0.49 2.94 1.47 0.49 2 0.98 3 1.47 - - 1 1 1 - 1.96 1.96 1.96 2 3.92 237858 HROAT> Hearing J3|iss ^ H/0.P4 ro Tuinor NOT EXPOSED It T r i m V #X 2 1.23 3 1.4 - EXPOSED. Tn*204T fX 'V 2 0.98 1 0.49 questionable __ETXnP-O'SsUlRE #I 1 1.96 2 3.92 - CARDIOVASCULAR' Retinal Nicking Varicosities * Localized Edema Pitting Edema Venous Stasis Diminished Pulses in Lower Extremities Cardiac Murmur, NOS Diastolic Murmur Systolic Hurmur Bruit ^Hypertension (see B.P. findings) H/0 Aortic "Ahrysn H/0 Arteriosclerosis H/0 Anemia - ---- H/0 Coronary Artery Disease H/0 Raynaud's Phenomenon H/0 Angina H/0 Hypertension PULMONARY ----- Increased AP Diameter, Chest Nasal Polyp Chronic Obstructive Pulmonary Disease (COPD) Rales - Breath Sounds, Vesicular Dullness to Percussion Crepitation Decreased Breath Sounds 6 3.68 10 6.13 1 0.61 1 0.61 5 3.07 0.61 0.61 5 3.07 - 6 2.94 30 14.71 2 0.98 5 2.45 10 4.90 9 4.41 1 0.49 - 1 0.61 - 10 6.13 1 0.61 2 1.23 36 22.09 1-- - i 20 - 0v49 0.49 9.80 3 1.47 60 29.41 - 1 0.61 1 0.61 1 0.61 3 1.84 - - 1 3 0.61 1.84 1 0.49 - 3 1.47 10 4.90 - 1 0.49 9 4.41 2 3.92 2 3.92 1 1.96 1 1.96 1 1.96 1 1.96 1 1.96 1 -.. 1.96 -- - 6 11.76 " 2 3.92 10 19.61 1 1.96 -. " 1 1.96 1 1.96 - \ 237SS9* .\` _T .. . / ; ; . N.\ , .. * itonchi , '` Clubbed Fiifiters^^^^B'Toes H/0 lung. Turrf|r '^ H/0 Bronchiall Asthma .H/0 Black Lung.^Benefits ^ .-fr H/0 Chronic Obstructive Pulmonary Disease (COPD) HOT EXPOSED Tn=WJT 11 4 2.45 2 1.23* EXPOSED tn-2b4j ; QUESTIONABLE EXPOSURE ''"Tri=51} " I .XV- 10 - 1 .. 0 . ** 1 ; 0.49 1 0.49 # 1 1 I 1.96 1.96 3 1.47 1 1.96 ORAL. Leukoplakia Poor Dental Hygiene and Caries Periodontal Disease 1 0.61 - 14 8.59 22 10.78 4 2.45 5 2.45 - 4 7.84 2 3.92 GASTROINTESTINAL H/0 Colitis 2 1.23 1 H/0 Diverticulitis 2 H/0 Colon Tumor 1 H/0 Cecal Tumor 1 H/0 Esophageal Tumor 1 H/0 Colon Cancer 2 H/0 Colostomy 1 H/0 GI Bleeding ;l/Q Upper. 61 Ulcer.----- --- ... ... 5 .9 ___ 5.52 ... .42 Site As Reported: Peptic -- Stomach -- . . .. 3 1.84 4 -- 2.45 9 21 Duodenal 2 1.23 12 Surgical Treatment as Reported: H/0 Gastrectomy H/0 Partial Gastrectomy 3 -1 H/0 Surgical Treatment of Ulcer, NOS r 6 LIVER ANO GALLBLADDER 0.49 0.98 0.49 1 0.49 0.49 0.98 0.49 2.45 ` 20.59... 3 5.88 - - .. 6.. 11.76 4.41 -10i29 -- -- -13--- 1,96 5.83 5.88 2 3.92 -- * .Enlarged Liver Tender Liver 4 2.45 2 . 1.23 8 3.92 2 0.98 1 1.96 - H/0 Hepatitis H/0 Cholecystectomy H/0 Cirrhosis H/0 Factor IX Deficiency -UROGENITAL 1 0.61 1 0.61 2 1.23 1 0.49 5 _ 2.45 - 2 3.92 1 1.96 - Enlarged Prostate Enlarged Testis Testicular Atrophy Inguinal Hernia 3 1.84 - 5 2.45 1 0.49 2 0.98 2 0.98 1 1.96 1 1.96 1 1.96 237860  NOT EXPOSED Tn=1`GT #X HypospaJias 1 0.61 Hydrocplje - S p e r m a t o f e l e r J U l a t e r a l 4> ft. ^ Phimosis V v,, - Balanitis 1 0.61 H/0 Kidney Stones 16 9.82 H/0 Hydronephrosis . H/0 Hematuria 2 1.23 H/0 Nephritis 3 1.84 H/0 Pyelonephritis - H/0 Prostatitis 4 2.45 H/0 Prostatectomy 2 1.23 H/0 Renal Abscess . H/0 Bladder Tumor 1 0.61 H/0 Prostate Cancer ;)H/0 Venereal Disease (Gonorrhea, Syphil - H/0 Infertility - H/0 Bladder Carcinoma 1 0.61 H/0 Renal Surgery LYMPHATIC Enlarged Lymph Nodes 2 1.23 Enlargect/Tonsils 1 0.61 .ENDOCRINE._ ... _ ........ . .... .. . Enlarged Thyroid Gland 1 0.`61 Exophthalmos H/0 Gynecomastia H/0 Diabetes H/0 Thyroid Disease * 1 3 - SKIN Cutis Marmorata Polymorphous Light Eruption - Nodular Elastosis of Favre-Racouchot 1 0.61 Radiation Dermatitis - Comedones, NOS' 14 8.5.9 Miliaria 1 0.61 EXPOSED Tn=2b'4T #% 4 1.96 1 0.49 1 0.49 1 0.49 24 11.76 1 0.49 5 2.45 3 1.47 1 0.49 6 2.94 2 0.93 1 0.49 7 3.43 1 0.49 2 0.98 1 0.49 62 0.98 2.94 2 0.98 0.49 i 0.4.9 9 4.41 3 1.47 1 0.49 1 Q.49 1 0.49 4 1.96 .q u e s t i o n a b l e ~ TEXPOSURE hVs * ..* 'ft 1 1 i95 1 1.96 5 9.80 - 1 1.96 1 1.96 - 2 3.92 - -* - 2 3.92 " 2 3.92 - - 2 3.92 1 1.96 - 1 1.96 8 15.69 237861 NOT EXPOSED TrpTlT . EXPOSED fna20TF a 4X 4% Cysts (irlu Sebaceous arnTKeratin) 8 4.91 `3 1 .A 7 Acne Vul^ri Chloracne^'. * 19 11.66 - 4 107 1.96 52.45 Rosacea - 3 -.1.47 Folliculitis 14 8.59 9 iA.41- Irritant Dermatitis 2 1.23 - Stasis Dermatitis ^ 5 3.07 2 0.98 Nurmiular Dermatitis 2 1.23 1 0.49 "Dishidrotic Dermatitis" 1 0.61 - ID Reaction 1 0.61 - Xerosis - 1 0.49 Lichen Simplex Chronicus - 4 1.96 Prurigo Nodularis - 1 0.49 Intertrigo 1 0.61 1 0.49 Drug Eruption - 1 0.49 Seborrheic Dermatitis Psoriasis". * ' 15 9.20 11 5.39 2 1.23 - 2 ` ^ 0.98 rCoMTM ! Actinic Elastosis 49 30.06 58.82 Xanthoma - 1 0.49 Dystrophic Toenails 2 1.23 5 2.45 Hirsutism Universal Hirsutism 3 1.84 . 11 5.39 1 0.61 - Pigmentation, NOS - 1 0.49 Hypopigmentation, Chemically Induced 1 0.61 1 0.49 Hypopigmentation, Post Inflammatory 1 0.61 3 1.47 Leukoderma and Vitiligo * ' 2 1.23 3 1.47 Hyperpigmentation, NOS - 4 1.96 Hyperpigmentation, Post Inflammatory - 1 0.49 Lentigo, Cafe au Lait Spots, Poikiloderma of Civatte 4 2.45 3 1.47 Hemosiderosis - 3 1.47 Idiopathic Guttate Hypomelanosis - 1 0.49 QUESTIONABLE EXPOSURE Tn=SVJ--- 4 1 2 " - 1 X 1.96 3.92. .V 1.96 3 5.88 - - - - - - 2 3.92 - - - 2 3.92 `3' 5:88 20 39.22 - - 1 1.96 - - - - 1 - 237862 Lihen SqiecodjFet Atrophicus . Hyperrlas^. SjBceous Gland Alopecia, fcircShcribed Keratoses, wOS' Seborrheic Keratoses-^** Actinic Keratoses Acanthoma ^ Keratoses Pilaris Junction, Dermal, and Compound Nevi Elue Nevi Peyronie's Disease Dupuytren`s Contracture Telangiectasis Spider Angiomata Verruca, Verruca Vulgaris, Molluscum Contagiosum .Fibropithlial Polyps.. ... Squamous Cell Carcinoma Bowen's Disease Basal Cell Epithelioma Trichoepithelioma Kel^ng*ra/Inpression Dermatofibroma Lipoma Angiomas Keurofibroma/Multiple Neurofibroma Herpes I NOT EXPOSED TfFlW 4% 1 0.61 - 2 1.23 10 6.13 9 5.52 1 0.67 15 9.20 1 0.61 - - 6 3.63 2 1.23 EXPOSED * =204) 1X 2 0.98 2 0.98 - 1 . . 0.49 ia 8.82 ' 21 10.29 2 0.98 - 13 6.37 -. 3 7.47 1 0.49 7 3.43 1 0.49 QUESTIONADLE EXPOSURE rn=51 ) I% - 7 1.96 7 1.96 7 1.96 6 11.76 5 9.80 - 1 1.96 3 5.88 - 7 1.95 7 1.96 - " 5 3.07 4 . 1.96 7 7.96 . 5 3.07 .. 2 _ 0.98 2 3.92 - 7 0.49 - 'to V 0.49 - - 7 4.29 74 6.86 1 0.61 . 1 - 1 0.67 -- - 2 1.23 2 0.98 - 2 1.23 5 2.45 7 1.96 4 2.45 3 7.47 7 7.96 1 0.61 1 0.61 7 0.49 237863 4> * ' . **at * Dermato^yti^ff' *1* . O n y c h o m y a s v .. \; - . Trichomycfeis fertMaife .Tinea Versicolor.;..: -- '" Dermagraphic Urticaria Ichthyosis Vulgaris V H/0 Dermatitis, NOS H/0 Pilonidal Cyst H/0 Acne Vulgaris H/0 Chloracne H/ Folliculitis H/0 Dishidrotic Dermatitis H/0 Xerosis H/0 Skin Cancer, NOS H/ Skin Tumor, NOS H/O Melanoma, Surgical Excision H/Q, Bas.al Cell Epithelioma INFECTIONS .-H/0. Malaria . H/0 Dengue Fever H/Q Rheumatic Fever __ NOT . EXPOSED Xn=)'6lT EXPOSED 'TnHBiT QUESTIONABLE EXPOSURE "n=5T) # t 45 27.61 16 9.82 " 1 0.61 1 0.61 - 16 9.82 1 0.61 48 29.45 - 2 1.23 1 0.61 1 0.61 4 2.45 1 0.61 1 0.61 - #t #1 62 30.39 " . ,.14 27.45 22 10.78 v 6 11.7$ 1 0.49 - ;i 0.49 - 1 1.96 - 3 1.47 - 11 5.39 1 0.49 20 9.80 176 86.27 1 0.49 - 8 3.92 - - 2 0.98 10 19.61 - 10 19.61 - 1 1.96 - - . 1 . 0.61 1 0.61 ......JL._ . ,0.49 _ ;,, 1 0.49 - - 237864 APPENDIX V Tafiie 20. Plasma Total Cholesterol (mg/d!) * White Males - Vi^t 2, Random Sample. The^SffMVHentfaStudy (North America). . N ' OVERALL . CLINIC R ANGE i) . r Mean S,E.*. Mean S.E. PERCENTILES V\(W 20 *j r w * -- '_ '-- -- -- -- 5-9 - t45 155.2 1.8 151.0 3.4 157.1 2.3 125 131 141 153 168 183 189 10-14 294 s 150.6 - 1.5 152.0 3.3 168.1 4.3 124 131 144 160 173 18a 202 15-19 298 153.0 1.4 150.6 2.6 155.5 2.5 118 123 136 152 168 183 191 20-24 118 162.2 2.5 163.0 5.6 163.5 3.2 118 126 142 159 179 197 212 25*29 253 178.7 2.1 171.3 4.1 187.8 4.7 130 137 154 176 199 223 234 30-34 403 133.1 1.8 185.6 4.6 204.1 5.9 142 152 171 190 213 237 258 35-39 371 200.6 1.9 186.6 4.5 147 157 176 195 222 248 267 214.8 6.6 T!AI(VU_4l4t*__ 383- -205.2- 1.9 -- ,*197:8 4.7-- t 150: T60 179" 204 229 251 260 210.3 5.8 -45-49 -- 326-- -213A 1.9 -- 201.0 3.9 -- 163 171 188 210 235 258 275 237.4 7.1 50-54 340 213.2 1.9 201.4 7.4 225.4 4.4 156 168 189 211 237 263 274 % 55-59 261 215.0 2-2 60-64 131 216.6 3.3 206.8 4.7 227.1 7.2 216.4 7.4 234.9 7.2 161 172 188 214 236 260 280 i 163 170 191 '215 237 262 287 65-69 105 * 221.0 3.8 211.8 6.6 225.7 5.1 166 174 192 213 250 275 288 704-5. 119 210.3 a 3.4 210.4 4.1 210.4 4.1 144 160 185 214 236 253 265 Nofr Mean notgiven ifN <: 25. Sthand 9SlhpercentilesnotgivenifN < 100; 10thand 90th percentiles notgiven ifN < 75. 25th and 75lh percem.'es noigivenifN < 50; 50th pefcenliie^not'givenilN < *0. Ckn*c range indicatestherange among Uod Research Ctmicstinelowest lRC mean value and thehighest LfiC mean value)and its respective SE. * The Lipid Research Clinics Population Studies Book: Volume I: The Prevalence Study, USDHHS, Public Health Service, National Institutes of Health, (1980), 237865 APPENDIX V Tab[-24.plasma Triglyceride (mg/dl) * .WhifeMales -Visit: 2. Random Sample. ' The LRCPreyale^p Study (North America).' 0* H * OVERALL CLINIC R A N G E Mean S.E. M e a n s.t. ii * PERCENTILES. 5 10 25 50 75 90. 95. - T S ---- &9 4S *-- - - -'* * .51.9 2: 1.7 50.2 3.5 53.2 2.1 -- ` *-- `-- ._ i 23 34 39 48 58 70 85 9i 10-14 299 63.4 1.6 53.9 5.2 67.2 4.5 33 37 46 58 74 94 111 15-19 299 7 8 .2 2.4 74.1 4.3 .38 43 53 68 88 125 143 80.1 4.1 20-24 118 89.3 3.7 . 87.9 5.2 98.5 9.4 44 50 61 78 107 146 165 i 25-29 2S3 104.2 4.2 80.2 5.4 45 51 67 88 120 171 204 125.3 14.1 30-34 403 122.1 3.7 95.4 4.6 48 57 76 102 142 214 253 148.0 22.3 35-39 372 140.8 5.5 ' 115.8 12.5 52 .58 80 109 167 250 316 160.8 19.4 4044 385 152.4 6.9 117.5 9.6 . 56 69 89 123 174 252 318 197.3 41.6 4549 327 143.4 5.9 124.4 8.7 56 65 88 119 t65 218 279 184.7 34.1 50-54 340 153.4 5.5 122.8 9.0 63 75 94 128 178 244 313 161.4 12.0 t 55-59 261 134.3 4:2 129.8 10.4 60 70 85 117 t67 210 261 146.9 12.1 60-64 131 130.6 8.7 '125.8 10.1 56 65 84 111 150 193 240 148.4 30.9 65-69 _ 105 . , 133.6 11.1 135.9 16.8 54 61 78 108 164 227 256 144.8 20.5 70+ 119 138: 7-2 130.9 6.9 130.9 8.9 63 7 1 87 115 152 202 239 Not: Mean notgiven if-N< 25: 5m and 95:ftpercentiles not given if N < 100: 10m and 9C:h percentilesnot given itN < 75: 2Stn and 7Slh percent.:esnot given itN < 50; 50thperccnbie not given rlN < *0. Clinicrang* indicates:rte rang rrong Liod Research Cimics (thelowest IRC mean vam and the hignest LRC mean vaiu) and ns respect SE. * The Lipid Research Clinics Population Studies Book: Volume I: The Prevalence Study, USDHHS, Public Health Service, National Institutes' of Health, (1930). \ 237866 APPtHUlA V Table 32. Plasm a LDL-CholesteroI (mg/dl) * \Vhite Males - Visite. R a n d o m Sample. Thetjl / jir BHncet Study (North America). v* N l(vqp OVERALL Mean S.E. 9 * *" 5r9 13f 92.5 s 1.8 CLINIC RANGE Mean S.E. -- 90.9 3.9 92.8 2.1 PERCENTILES 5 10 JL"- 25 50 75 90:??95 -- r iir -- -- -- ' -- 63 69 80 90 103 117 ,129 a' 10*14 284 **96.5 1.4 1^19 298 94.4 1.3 84.8 3.0 101.5 3.8 92.5 3.4 95.5 2.3 64 72 81 94 109 122 132 62 68 80 93 109 123 130 0^4 118 103.3 2.4 101.6 3.0 108.4 5.2 66 73 85 101 118 138 147 25-29 253 116.7 1.9 109.6 3.5 120.6 - 4.7 70 75 96 116 138 157 165\ 30-34 403 126.4 1.6 119.8 4.4 128.7 5.7 78 88 107 124 144 166 185 35-39 371 133.2 i 1.7 118.4 3.9 146.3 5.8 81 92 110 131 154 176 189 .. 4044 385.-- 135.6 , 1.6 ..129.5 x 4.3 146.1 4.5 87., 98 115 1.35. .157, 173 J.86 .. .4543. 325 ..-1.43.9x1,8 . .. 132.9 3.6.. 98. 106 120, 141 163 166 202 . 155.8 - 6.6 30-34 340 142.3 - 1.7 * 137.0 4.2 154.1 4.2 89 102 118 143 162 185 197 35-33 261 145.8 2.1 137.0 5.6 160.5 5.9 88 103 123 145 168 191 203 60-64 131 146.3 - 3.1 148.2 5.1 157.3 7.2 83 106 121 143 165 188 210 6fr69 105 "150.4 = 3.5 146.3 :t 5.5 153.4 5.0 98 104 125 146 170 199 210 7Q-K 119 142.9 s 2*9 141.5 3.5 141.5 3.5 88 100 119 142 164 182 186 Ng* W een not g iv e n rf N <* 2 5 : 5jn an d 95m p e rce n tile s not g iv e n it N < 100: VQJO no 90:n p e rc e n tre s not g iv e n rt N < 75. and 75if> pe rce n t.ie s not g iv e n rt N < 50: Sfljf p e rc e n u e not give n rf N *- *0 . Q}n< range m o c a iM me rang among U o d fta se a rc n Ckruca (me low est L f lC m ea n vatu ftptttne hignest L R C m ean value) and as r0ective SE. * foe H pid Research Clinics Population Studies Book: Volume I: The Prevalence Study, USOHHS, Public Health Service, National Institutes v T H q thTTl 930 j. 237857 Taijle'3*PIasma.HDL-C5io!estero! (mg/dlj* White Males -Njsit 2. Random Sample. T h e ^ -^ l^ to g le o ce Study (North America). m m r e J C t r s . i . - J ' i i n - T i l l i r inm rur wM mm ii n j J i P i u ^ n | -| e N OVERALL . CLINIC RANGE. PERCENTILES l r s ) (tlvoBoUnV4w- WQtCa* U a SH .QF :v A6* - . 5 .10 25 50 75 90 95 r-4-*> 4mm"- ` ; ^\ L -- -- -- -- -- '-- ' ' 5-9L. \ 4 t 55.5 ~ 1.0^ ;54.8 1.8 55.6 1.1 38 42 49 54 63 70 74 10-14 296 ^ 54.9 0.7 53.9 1.0 58.5 2.3 37 40 46 55 61 71 74 15-19 299 46.1 0.6 42.2 1.2 48.6 1.6 30 34 39 46 52 59 63 20-24 118 45:4 1.0 40.0 1.6 46.2 1.8 30 32 38 45 51 57 63 25-29 253 44.7 0.7 39.6 1.8 45.7 1.2 31 32 37 44 50 58 63 30-34 403 45.5 0.6 39.8 1.6 50.2 2.2 28 32 38 45 52 59 63 35-39 371 43.4 0.6 34.6 1.2 48.0 1.8 29 31 36 43 49 58 62 4<M4 383 44.3 0.6 35.5 1.7 27 31 - 36 43 51 60 67 ' 49.9 2.1 " 45-49 325 45.4 0.6 40.2 2.0 30 33 33 45 52 60 64 " 49.3 22. - 50-54- 340 44.1 0.6 36.5 1.3 50.1 2.1 28 31 3' 6 44 51 58 63 55-59 261 47.6 0 3 . 41.2 1.6 51.1 3.0 28 31 38 46 55 64 71 60-64 131 51.5 1.3 44.8 2.2 54.6 2.3 30 34 41 49 61 69 74 65-69-- 105 51.1 1.5 41.2 2.1 56.7 2.1 30 33 39 49 62 74 78 70+ 119 50.5 1.7 53.2 2.1 53.2 2.1 31 33 40 48 56 70 75 0 Note: Mean nof given it N < 2 5: 5th a n d 95in p e r c e n t e s n o t g iv e n if N < 100; 10th an d SOih percen:..es not given il N < 75. 25th a n d 75th percentue* not give n il N < 50; 50th peroentiie riot given it N < 0 . C f i m c range indicates the range am ong L o d R esearch O n e s fine lowest l R C m ean value an d the highest L R C m ea n v a lu e ) a n d rta respective SE. * The lipid Research Clinics Population Studies Book: Volume I: The Prevalence Study, USOHHS, Public Health Service, National Institutes of Health, (1980). 237868 APPENDIX VI Logistic Regression alHnary variable (e.g., FEV-j, noriflal or abnormal) each subject's probability o ^ a pflwtiye response is-modeled as a function of one or more predictor variakles^tin this example, exposure group and pack years smoked) as follows: Prob (FEV-j abnormal) - -j + `exp(-(o + S-j x Pack Years + whore Z - 1 if exposed 0 if not exposed x Z) ) The Newton-Raphsom method is then applied to the entire sample to produce laaximum likelihood estimates of the coefficients of pack years smoked and Z% the exposure variable. More details are given in The Analysis of Binary Data (Q,R* Cox, Chapman an'4 Hall (1970) London). The Paximum likelihood estimates for the exposed vs. not exposed comparison found are as follows; Pulmonary Function Parameter Coefficient FVC FEV-j/FVC MMEFR Intercept -3*54 -3.10 -3.43 -2.64 Pack Tears SKQZ ^ 0.02 0.02 0.03 Exposure t*Q0 0.74 1.06 0.60 23786'S ' ^ *> APPENDIX V U f8 Clinical Laboratory Values Reference Range ;* W C a l c i u m ....................................'. . P h o s p h o r u s ............................... B U N ..................................... C r e a t i n i n ................................ G lu c o se . . . . . . . . . . . . . . . . U n c A c i d ............... T o t a l P r o t e i n ............................ A lb u m in . . . . . . . . . . . . . . . . A l b G l o b R a t i o ................... G lo b u lin . . . . . . . . . . . . . . . . S G O T ............................. S G P T ............................................. L O H ................................................ T o t a l B i l i r u b i n .......................... D i r e c t B i l i r u b i n ................... A ik . P h o s p h a t a s e .................. G G T P ............................................. S o d iu m . . . . . . . . . . . . . . . . . P o t a s s i u m ...................... C h l o r i d e ...................................... T o t a l L i p i d s ............................... T r i g l y c e r i d e s . .......................... C h o lu c lo ro l . . . . . . . . . . . . . I r o n .................................................. 6 . 0 > 10.8 2 . 0 - 4.7 6 25 0 . 5 , . 1.7 65 2 .5 130 - 6.5 6 . 2 - 6.3 3 6 - 5.2 t.O - 23 1 9 3 .7 1 1 90 0 .1 0 10 - 70 - 70 260 - 1.7 0.3 - 50 \1 104; 3 -5 96 (* 40 145 55 110 0 . 3 1.0 60 125 200 300 * 5 200 MG/DL M G /D L M G /O L M G /D L M G /O L M G /D L G M /D L G M /D L G M /D L IU /L IU /L U N IT S M G /D L M G /D L U N IT S /L 1IM IT C 4 ..IMMOLA. A 1M O U L K 1M O U L G M /D L M G /D L M G /D L M C O /O L I * + 1, j :1 !1 3 .i \ ! 1 ! \, * f 1 V THYROXINE-BINDING GLOBULIN (TBG) R eferen ce R an g e; 1 2 - 3 0 ' M C G /M L P ro g n an t w o m o n or women taking the pH: G.T 15 MCG/ML V f U RIN ALYSIS AppOBrance pH S p e c ific G ra v ity A c e to n e A lb u m m G iu u o se B lo o d W liC RUC C asi B.ictona E p ith e lia l C e lls Clear 4 .8 - 7 .5 1 .0 0 1 - 1 .0 3 5 N e g a tiv e N e g a tiv e N e g a tiv e N e g a tiv e 0 -5 /H P F 0 -2 /H P F N e g a tiv e N o g a liv e N e g a tiv e 4t JR'*"' 4 i~! i'r CBC WITH DIFFERENTIAL W BC RBC M a le ; F e m a le : HEMOGLOBIN HEMATOCRIT MOV M CH M CHC PO LY S BANDS LY M PH OCY TES M ONOCYTES E O S IN O P H IL S B A S O P H IL S D iffe re n tia l Absolute Values N E U T R O P H IL S LY M PH OCY TES M ONOCYTES E O S IN O P H IL S B A S O P H IL S M a le ; F o rn a le ; M o la : F e m a le : 4 .0 - n t TtoMy v - 6.2*Million/ i 4 .2 - 5 .4 m o n tM U CU.MM f 1 4 ,0 12 0 42 37 602631 42- 010- 000* 1 8 .0 m i a u e t 1 6 .0 G M /D L ^ V 54 PER C EN T ' 49 PERCEN T 100 U 3 ,-.r k 33 UUG 36 PERCEN T 81 PE R C E N T 5 PERCEN T 47 PER C EN T, 10 PE R C EN T 1 8 PERCEN T 2 PERCEN T Vi 1650- 6330 1049- 3581 61 - 9 29 4 0 - 423 1 0 - 148 C e ils /C .M M C c lls/C U .M M C e lts/ U .M M C ells/C ,U .M M C o lls/C U .M M PO RPH YRIN S, U RIN E, QUANTITATIVE C o p ro p o rp h y rtn 30 2 4 0 M C G / 2 4 hrs. U io p o ip h y n n 1 5 - 6 0 M C G 2 4 h f* . t 7 h i' ` 237870 V APPENDIX VIII Jl . Hutment of Nerve Conduction Velocity Data ,i * ' fcForgfurposes of analysis of the nerve conduction findings, all cases reporting consuming* more than 35 0 2 . of alcohol jgr week were eliminated. Also dropped from the analysis were all subjects giving a history of diabetes. "* To correct for temperature effects a mode temperature was calculated for each limb across all participants in the study. The following data adjustments were then made: Ulnar or Peroneal a) NCV's were corrected to the mode of the midpoint nerve temperatures using DeJesus et al.'s (1973) temperature correction equation, Vs = Ve e0.0419AT where Vs = standardized NCV to standard^ (mode) temperature Ve * measured velocity at the experimental temperature AT = difference in C between- standard and experimental temperatures b) Distal latencies were corrected to the mode of the distal temper atures using DeJesus* temperature correction equation: DLS = bL-.e'`0507iT `-- * DLS s corrected distal latencies to standard temperature DLg s measured distal latency at the experimental temperature AT = as above c) Residual latencies were calculated by subtracting from the latency (derived in b above) the terminal distance divided by the standardized NCV (derived in a above). 237871 d) UlstarTatencies derived in b above'were correct to the mpde of the * ** i nerve terminal distances using the equation below: -Wt ^ -v-,, Ls * * Lc+ ^ where "s Ls1 = latency standardized to standard (mode) distance aft: Le l a t e n c y derived in b above Vs = velocity derived in a above As * difference between standard (mode) and experimental terminal distances e) Ratio of amplitudes (proximal divided by distal) was calculated 5ural The only standardisations performed on the sural nerve consisted of correcting the velocities to the mode.of the midpoint nerve temperatures as in a above. 237872 APPENDIX .IX. Normal Nerve Conduction Velocity and Distai Latency Conduction Velocity Average & Range Meters/sec> Distal Latency msec .peference Peroneal Motor Fibula Head-Ankle ^ Sural Sensory Lateral Malleolus-Calf (Ortho) 56.4 S.D.4.8. 57 .*5(49.5-63.6) 50 S.D.3.5 46.2 t 5 2.&(2.0-3.4). 5 . 1 .S.D.0.5 /.;.1 2 3 1 Trojaborg, W., Electroenceph. Clin. Neurophysiol., 17:314-321 , 1964. Z+ McQuillen, M.P. and Gorin, F.J., J. Neurol. Neurosurg. Psychiat., 32:144-148, 1969. 3* DIBenedetto Temperature effects on nerve conduction velocity: (2 to 2.4) meter per _ second _/C. Meaningful conduction velocity of peripheral nerves can be made onty I f segrnent , size, g, and temperatur are known. ...... ` Typical peak-to^peak amplitudes-using recording electrodes at sites____ referred to in this manual. Ulnar Motor: 10 - 20nV Peroneal Motor: 10 - 20mV Sural Sensory: 20 - 28uV T 2378T3 APPENDIX X. J DEFINITION OF ALCOHOL STATUS ' '3* . IF "Do ou tjWis^dr^iR alcoholic beverages?" AND "If no, did you ever?" i. = NO = NO THEN ALCOHOL STATUS = NEVER IF "Do you now drink?" AND "If no, did you ever?" = NO = YES THEN ALCOHOL STATUS = FORMER IF "Do you now drink?" * YES THEN ALCOHOL STATUS = PRESENT 237874 APPENDIX X s DEFINITION OF SMOKING jF "t^yott^greseat 1^ s m o k e cigarettes?" AND "If not now^-rfid you ever smoke?11 = NO = NO THEN SMOKING STATUS = NEVER IF "Do you smoke now?" AND "If you do not now smoke cigarettes, have you smoked them in the past?" = NO - YES THEN SMOKING STATUS = FORMER IF "Do you smoke now?" * YES THEN SMOKING STATUS * PRESENT 237Q: DEMOGRAPHIC DATA* *t s way Reaction Subjects vs. Not Exposed ** AGE .-Mean j Sfendard Cgviation Exposed (55) Not Exposed (65) 62.73 t 7.92 59.40 8.83 0.01 < p < 0.05 HIGHEST EDUCATION LEVEL TCP Runaway Exposed Percent 0 - 8th Grade 9 - 1 2 ^ Grade > 1 2 ^ Grade Total 7 . 12.73 41 74.55 : 7 12.73 55 b .di < p< Not Exposed 2 45 17 6 t* .oion EMPLOYMENT STATUS 'iF .TCP Runaway Exposed Percent Active Retired Terminated Total 13 32 10 *- 55 23.64 58.18 18.13 " p <0.0001 Not Exposed 42 22 1 65 Percent 3.13 70.31 26.56 Percent 64.62 33.85 1.54 * All subjects white males ** Information not available for one (1) subject l 237876 EXPOSURE vs. SH0KNG STATUS*-* * . TCP Runaway Exposed Percent rer^ Former Present Total m * 13 23.64 24 43.64 18 32.73 55 p N.S. Not Exposed 15 35 15 65 Percent 23.08 53.85 23.08 TCP EXPOSURE vs. PACK YEARS SMOKED* TCP Runaway Exposed (55) Not Exposed (65) Mean t Standard Deviation 36.66 t 36.13 26.01 32.42 * 0.05 < p < 0.10 for comparing TCP Exposed to Not Exposed EXPOSURE vs. ALCOHOL STATUS* TCP Runaway Exposed Percent Never Former Present Total 6 11.54 21 40.38 25 48.08 52 p N.S. Not Exposed 9 24 31 64 Percent 14.06 37.50 48.44 * For definition, see Appendix V 2378-7 FAMILY HISTORY=0F ILLNESS * Family History of Asthma Hayfever Acne Eczema Hives Ulcers Colitis Heart Attack or Angina before Age* 60 Heart Attack or Angina after Age 60 High Blood Pressure Cer.ctrovAscular Accident (OVA) High Chilesterol \ [iabe tel LNHe'tvverous Inher Cancer TCP Runaway Exposed tn=bbT l% 6 10.91 4 7.27 4 7.27 4 7.27 4 7.27 G 14.55 4 7.27 17 30.91 21 38.18 20 36.36 18 32.73 4 7.27 10 10.10 2 3.64 8 14.55 2 3.64 24 *43.64 * Includes Parents.!and Siblings of Subjects O Not Exposed (n=65) 11 8 ;12.31 ;5 . 7.69 2 3.00 3 , 4.62 * 5 7.69 9 13.35 :4 6.15 17 i26.15 17 26.15 23 35.jO t 28 43.086 9.23 15 23.08 5 7.69 ;9 13.05 2 I 3.00 21 32.31 Probability i;.s. N.S. N.S. N.S. N.S. N.S. N.S. N.S. N.S. . N.S w.S. N.S. .N.S. N.S. N.S. N.S. N.S. 237878  237879 . History of . Chloracne* Acne Vulgaris . FoilIcul ftls Skin Cancer ,* - Chronic-Obstructive Pulmonary Disease.(dPD) Hypertension Arteriosclerosis Arigina ^ C o r M r y - Atter^ Disease Cerarvascular Accident (CVA) ProstnFipisea^ Kldnj^StjJSA**^ 1 p< O.OOOl HISTORY OF MEDICAL PROBLEMS VS. : EXPOSURE STATUS TCP Runaway Exposed (n 5b) L1 55 100.00 3 5.45 0 0.00 3 5.45 1 1.82 i ; t ; 20 36.36 i 0 0.00 'c 1 1.82 8 14.55 2 3.64 ' *1 1.82 ' 2 . 3.64 3 5.45 . i i ti j | Not Exposed tnB5 ) #% 0 0.00 6 9.23 0 0.00 3 4.62 Z 3.08 23 35.38 V 1.54 1 l.$4' 10 15.38 2 3.08 1 1.54 3 4.62 9 13.85 Finding Chloracne* Acne Vulgaris Actinic Elastosls2 Actinic Keratosis Alopecia, circumscribed Acanthoma Basal Cell Epithelioma Depigmentation Dermatitis Irritant Nymrtfu 1ar ^ ;Seborirhe1^3 % J / S t aWs 3 f* %^ Dermat<*hytos1s Qnychomlcosls ' J (' Dopuy trdhff^PiWB*acture Peyronie's' Disease^ FolUculitTs Hirsutism Ichthyosis Vulgaris % * Hot jslve CLINICAL FINDINGS* vs. ! EXPOSURE jtp Runaway Exposed (n*i)b ) i% 32 58.18 0 0.00 41 74.55 6 10.91 0 0.00 1 1.02 5 9.09 1 1.82 0 0.00 1 1.82 1 1.82 0 0.00 14 25.45 7 12.73 0 0.00 2 3.64 0 0.00 4 7.27 1 1.02 23780C Not Exposed (nr 65 } K% 0 0.00 1 1.54 32 49.23 8 12.31 0 0.00 0 0.00 7 10.77 1 * 1.54 1 1.54 1 1.54 8 12.31 5 7.69 26 40.00 13 20.00 0 o.qo 0 o.oo 1 1.54 2 3.08 0 0.00 Finding Lichen Simplex Chronicus Lipoma Melanoma, impression Miliaria Neurofibroma, multiple Poikiloderma Psoriasis Rhinophyma/Rosacea Squamous Cell Carcinoma, impression Xeroses m Nerj*ousne*/Anx1ety/ 3 \ Diastolic Decreased libido (H/0) H/0, Impotence, NOS * % Not i 'r ^1c1ve * CLINICAL FINDINGS vs. EXPOSURE TCP Runaway Exposed (n*55 ) #% 1 1.82 2 3.64 0 0.00 0 0.00 1 .....1-82 0 "o.oo 1 1.82 0 0.00 0 ` 0.00 0 ,:o.oo 12 21.82 7 12.73 0 0.00 13 23.64 9 16.36 2378S1 Not Exposed [n65T" 1% 0 0.00 1 1.54 1 1.54 1 1.54 0 0.00 0 0.00 1 1.54 0 t 0.00 0 0,00 0 0.00 5 7.69 4 6.15 1 1.54 10 15.38 4 6.15 p'^f'OOOl for comparing TCP vs. Not Exposed i^ -,* OiOOl' < p < (^pl^for comparing TCP vs. Not Exposed 0.05<p<0.10 for comparing TCP vs. Not Exposed 237862 .. Serum Lipid Cholesterol Triglycerides LDL, estimated HDL i* EXPOSURE VS. SERUM LIPID; FINDINGS TCP Runaway Exposed n TOAbnormal) 54 5( 9.ZG) 54 8(14.81) 54 5( 9.Z6) 54 9(16.67) Not Exposed n #l%Abnormal) 65 8(12.31) 65 16(Z4.62) 63 4( 6.35) 65 6( 9.23) Probability N.S. N.S. N.S. N.S. <I f ) Pulmonary Function Parameter FEVi FVC FEVj/FVC , MMEFR EXPOSURE vs. PULMONARY TEST FINDINGS TCP Runaway Exposed (n* 55 ) ' (X)Abnormal ! Not Exposed ln= 641 (X)rtbnormal 11 20.00 6 9.38 12 21.82 7 ; 10.94 j 15 27.27 5 7.81 17 30.91 11 17.19 Probability N.S. N.S. 0.0092 N.S. ; if !t 237884 J 9. i EXPOSURE' ys. | SERUM LIPID FINDINGS BY:SMOKING STATES.. v ,y .* .Serum Lipid Smoking Status Cholesterol - Never ' Former Present Triglycerides * * , 4* * \i\ .V .; / ' LDLy .estimated Never Former Present Never Former . Present , '/ < ,* ' . > Never Former Present TCP Runaway Exposed n 0(%)Abnormal t i f Not Exposed n #(%)Abnorma1 12 1( 8.33) . 15 2(13.33) 24 2( 8.33) 35 1 3( 8.57)' 18 2(11.11) 15 3(20.00) 12 1( 8.33) 24 4(16.67) 18 3(16.67) 12 1( 8.33) 24 2( 8.33) 18 2(11.11) r 12 1( 8.33) 24 4(16:67) 18 4(22.22) 15 5(33.33) .35 6(17.14) 15 5(33.33) % ! :*15 ! 1( 6.67) 33 1( 3.03) 15 2(13.33) 15 . 2(13.33) 35 , 3 8.57 : 15 ! 1{ 6.67) Probability N.S. N.S. N.S. N.S. N.S. N.S. N.S. i N.S. . N.S. i N.S. N.S. N.S. i U W i '4 Pulmonary Function Parameter FEV1 * FVC .* FEVj/FVC ' FWEFR EXPOSURE vs* PULMONARY TEST FINDINGS TCP Runaway Exposed (nc 55 J IX)Abnormal Not Exposed ; (X)bnormal 11 20.00 !6 9.38 i 12 21.82 ;7 10.94 15 27.27 5 7.81 17 30.91 11 17.19 Probability N.S. N.S. 0.0092 N.S. 237866 i 237887 Pulmonary Function Parameter FEV, FVC FEVj/FVC MMEFR .* EXPOSURE VS. ! PULMONARY TEST FINDINGS BY SMOKING STATUS Smoking Status TCP Runaway Exposed Never Former Present ... 13 24 18 Never Former Present Never Former Present 13 24 18 13 24 18 Nev,er Fofaer Presect 13 24 ' 18 .P 1( 7.69) 4(16.67) 6(33.33) 1( 7.69) 6(25.00) 5(27.78) 2(15.30) 5(20.03) 8(44.44) 2(15.38) 6(25.00) 9(50.00) NotL Etxposceda F( Abnormal 15 34 ; 15 15 34 15 15 ' 34 : 15 . 15 34 15 2(13.33) 3( 8.82) 1( 6.67) 3(20.00) 3( 8.82) K 6.67) j 1( 6.67) 4(11.76) 0( 0.00.) 1( 6.67) , 8(23.53) 2(13.33) Probability N.S. N.S. N.S. N.S. N.S. N.S. N.S. N.S. 0.0063 N.S. N.S. i 0.0599 I i* EXPOSURE vs.' ECG FINDINGS Finding TCP Runaway Exposed (n= 55) l% Normal ECG Negatlve'ECG* Sinus Bradycardia Sinus Tachycardia PVC'sl PAC's .Atrial Fibrillation Intraventricular Conduction Oefect Left Anterior Hemiblock 1st Degree AV Block?i Rig|rff B u ^ H e Branch i^ck, complete 9 16.36 25 45.45 7 12.73 *t.0 0.00 10 18.18 1 1.82 1 1.82 2 3.64 5 9.09 0 y 0.00 ; l '!* 1.82 Lett BurtRe Branch 1llo6k, complete Olid Antefcor MyocardiaJ'/Infarct Old I n f taV Infarct True Posterior Mybcardial Infarct D i g i t a l ^ - G # * 8^ l .1.82 l .1.82 3 5.45 0 0.00 2 .3.64 * 1- 0.01 < p<0.05 for comparing TCP vs. Not Exposed. * Normal or not significant findings ) 237883 i I Not Exposed tn "65) #% 15 23.08 33 50.77 3 4.62 1 1.54 3 4.62 4 6.15 1 1.54 1 1.54 2 3.08 2 3.00 2 3.08 0 0.00 2 3.08 2 3.08 1 1.54 1 1.54 Finding Left Ventricular Hypertrophy Right Ventricular Hypertrophy Left Atrial Hypertrophy Non-specific ST-T Wave Changes Low Voltage QRS Abnormal P Wave Left Axis Deviation EXPOSURE vs. ECG FINDINGS TCP Runaway Exposed Wl>57 t* i 3 5.45] 0 0.00 0 0.00: 2 3.64 1 1.82 2 3.64 0 0.00 1 237889 Not Exposed (- 65) #% 5 7.69 0 0.00 0 0.00 3 4.62 0 0.00 4 6.15 1 1.54 I EXPOSURE vs. PULMONARY TEST FINDINGS BY SMOKING STATUS Pulmonary Function Parameter t- Smoking Status TCP Runaway Exposed (^Abnormal FEVi Never Former Present 13 24 18 FVC Never 13 Former 24 Present 18 FEVj/FVC Never Former Present 13 24 18 MMEFPi ' <*r> ' * Never Former Preijsrt. 13 24 \ 18 1 f \ ii L r \ - n> .. f;; \ t W B B R I P * 1 J>' *? 1( 7.69) 4(16.67) 6(33.33) 1( 7.69) 6(25.00) 5(27.78) 2(15.38) 5(20.03) 8(44.44) 2(15.38) ' 6(25.00) 9(50.00) Not Exposed n Tf?)Abnormal 15 34 15 1 15 1 34 . 15 : 2(13.33) 3( 8.82) 1( 6.67) 3(20.00) 3 8.82 i( ct:g 7) 15 i 34 ! 15 15 34 15 i( 6.67) 4(11.1$) 0( 0.00%) 1( 6.67) 8(23.53) 2(13.33) Probability N.S. N.S. N.S. N.S. N.S. N.S. N.S. N.S. 0.0063 N.S. N.S. 0.0599 \ 237820 EXPOSURE vs. CHEST X-RAY FINDINGS Finding Normal Chest X-Ray * Evidence, Old Granulomatous Disease* Evidence, Arteriosclerosis Evidence, Degenerative Bone Disease Cardiomegaly Mass Chronic Obstructive Pulmonary Disease (COPD) Aortic Aneurysm Pulmonary Hypertension Blunted Costophrenic Angle Acute Parenchymal Disease A Elevated Hemi-diaphragms Pleural Thickening p a r e n c h y m a l Scarring p o s s i b l e Mass G&ortic Valve Disease &rauma TCP Runaway Exposed fn=55TMT #% 14 25.45 23 41.02 11 20.00 a 14.55 5 9.09 2 3.54 2 3.64 0 0.00 0 0.00 6 10.91 :$' 0 0.00 4 7.27 6 10.91 6 10.91 1 1.02 0 0.00 2 3.64 * O.Ol < p < 0.05 for comparing TCP vs. Not Exposed Not Exposed ~W 65T~ l* ,29 44.62 14 21.54 12 18.46 4 6.15 2 3.00 1 1.54 3 4.62 0 0.00 1 1.54 6 9.23 1 1.54 1 1.54 3 4.62 8 12.31 4 6.15 0 0.00 2 3.08 BLOOD Calcium Phosphorus BUN Creatinine Uric Acid Glucose (CS) Total Protein Albumin Globulin Albumin/Globulin ratio Total Bilirubin Direct Bilirubin Transaminase, SGO Transaminase, SGP Alkaline Phosphatase DH ,ron CLINICAL LABORATORY FINDINGS vs. I EXPOSURJ STATUS; TCP Runaway Exposed n i(%Abnormai) Not Exposed , n tf(%Abnormal) ! 53 0(0.'00) 52 0(0.00) 53 5(9.43) 52 1(1.92) 53 3(5.66) 52 3(5.77) 53 1(1.69) 53 0(0.00) 53 0(0.00) 53 lUvjH) 53 0(0.'00) 53 3(5.66) 52 2(3.85) 52 2(3.85) 53 2(3.77) 52 3(5,77) 53 1(1.89) 63 62 63 63. .62 ; o2 62 62 '62 62 63 63 62 6263 6263 0(0.00) 3(4.84) 4(6.35) 0(0.00) 2(3.23) 5(8.GS) 1(1.61) 0(0.00) 0(0.00) 0(0.00) 0(0.00) 4(6.35) 1(1.61) 1(1.61) 2(3.17) 2(3.23) 0(0.00) \ !*i - .AT CGSafg.. i Sodium Potassium Chloride G-glutamyl transpeptidase Thyroxine binding globulins CBC WBC ROC HGB HCT HCIIC1 HCH MCV fferential Poly Lymph Mono Eos Basa CLINICAL LABORATORY FINDINGS VS. * . ; EXPOSURE STATUS' TCP Runaway Exposed n i t ^Abnormal) 53" 52 53 53 53 2( 3.77) 0( 0.00) 1( 1.89) 4( 7.55) 12(22.64) Not Exposed n f(%Abnormal) ; 63 0( 0.00) : 62 0 ( o.opj : 62 2( 3.23) 63 K 1.59) 63 16(25.40) 53 3( 5.66) . 63 3( 4.76) 53 0( 0.00) : 63 i( 1.59) 53 6(11.32) i 63 6( 9.52) 53 7(13.21) : 63 8(12.70) 53 20(37.74) 53 6(11.32) : 63 63 13(20.63) 8(12.70) 53 28(52.83) 63 27(42.86) 53 1( 1.89) 53 2( 3.77) 53 1( 1.89) 53 0( 0.00) 53 0( 0.00) : 63 63 62 63 ^ 63 1( 1.59) 1( 1.59) 0( 0.00) 1( 1.59) 1{ 1.59) 237894 CLINICAL LABORATORY FINDINGS vs. ' * EXPOSURE STATUS . Urinalysis Acetone Albumin Bacteria Blood Glucose White Blood Cells TCP Runaway E>cposed r n *7fPositive) V Not Exposed n f(XPositlve) A. 52 0(0.00) ' 63 0( 0.00) 52 1(1.92) 63 0( 0.00) 52 2(3.85) 63 7(11.11) 52 0(0.00) 63 1( 1.59) 52 0(0.00) ; 63 1( 1.59) 52 1(1.92) 63 3( 4.76) 1 0.05 <p< 0.10 for comparing TCP Exposed to Not. Exposed \ 4 i % DEMOGRAPHIC DATA* / Reaction vs: Other Exposed AGE 0* Exposed (55) Other Exposed (77) Hean t Standard Deviation 62.73 1 7.92 63.06 + 5.59 P N.S. HIGHEST EDUCATION LEVEL TCP Runaway. Exposed Percent 0 - 8th Grade 9 - 12th Grade 7 41 12.73 74.55 > 1 2 ^ Grade _7 12.73 Total 55 P N.S. Other Exposed 12 54 10 76** EMPLOYMENT STATUS . TCP - Runaway ' Exposed Percent Active Retired Terminated Total 13 32 10 `Sa 55 23.64 58.18 18.18 0-01 <p< 0-05 Other Exposed 35 37 _5 77 Percent 15.79 71.05 13.16 Percent 45,45 48.05 6.49 * All subjects white males ** Information not available for one (1) subject 237895 EXPOSUjSvs. SMOKING STATUS* -- -- "M Ir * 1 3 IR * ^V-"v RunTCaPway ^Exposed Never Former Present Total 13 24 y 18 55 Percent 23.64 43.64 32.73 p N. S. Other Exposed 15 36 25 76 Percent 19.74 47.37 32.89 TCP EXPOSURE vs. PACK YEARS SMOKED* TCP Runaway Exposed (55) Other Exposed (73) Mean t Standard Deviation 36.66 t 36.13 27.13 t 26.01 * 0.05 < p <0.10 for comparing TCP Exposed to Other Exposed EXPOSURE vs.,ALCOHOL STATUS* TCP Runaway Exposed Percent Never...... Former Present Total 6 21 " 25 *52 11.54 40.38 48.08 P N.S. t ,-- ........ .... - * For definition, see Appendix V Other Exposed 7 33 30 70 Percent 10.00 47.14 42.86 237896 237897. r FAMILY HISTORY OF ILLNESS * Family History of Asthma Hayfever Acne Eczema Hives Ulcers Col 1tis Heart Attack or Angina before Age 60 Heart Attack or Angina after Age 60 High Blood Pressure Cerebrovascular Accident {CVA) High Cholesterol Diabetes Liver Disease Nervous Disorder Inherited Disorder Cancer TCP Runaway Exposed fn=55T Ii .f 6 4 10.91 7.27 4 7,27 4 7.27 4 7.27 8 14.55 4 7.27 17 30.91 21 38.18 20 36.36 18 32.73 4 7.27 10 18.18 2 3.64 8 14.55 2 3.64 24 43.64 * Includes Parents and Siblings of Subjects Other Exposed "Tn='771 l1 12 15.58 3 : 3.90 | 9 11.69 6 7.79 8 10.39 12 15.58 7 9.09 19 24.68 26 - 23 25 i 6 18 7 12 5 31 33.77 % 29.87 32.47 7.79 23.38 9.09 15.58 6.49 40.26 Probability NS .NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS ( HISTORY OF MEDICAL PROBLEMS VS. EXPOSURE STATUS History of Chloracne* Acne Vulgaris Foiliculitis Skin Cancer Chronic Obstructive Pulmonary Disease (COPD) Hypertension Arteriosclerosis Angina Coronary Artery Disease Cerebrovascular Accident (CVA) Bladder Cancer Prostatic Disease Kidney Stones TCP Runaway Exposed 1 (h" 55) L t% 55 100.00 3 5.45 0 0.00 3 5.45 1 1.82 20 36.36 0 0.00 1 1.82 8 14.55 2 3.64 1 1.82 2 3.64 3 5.45 , i *0.001 < p < 0.01 for comparing TCP to Other Exposed; Other Exposed ~Tn^ 1 1 T ~ i% 64 83.12 5 6.49 0 0.00 5 6.49' 2 2.60 25 32.47 0 0.00 0 0.00 10 12.99 4 5.19 1 1.30 3 3.90 7 9.09 237898 DOO^L6 Finding Chloracne Acne Vulgaris Actinic Elastosis Actinic Keratosis Alopecia, circumscribed Acanthoma Basal Cell Epithelioma Depigmentation Dermatitis Irritant Nunmu 1ar Seborrheic Stasis Dermatophytosis Onychomycosis Dupuytren's Contracture Peyronie's Disease Folliculitis Hirsutism Ichthyosis Vulgaris * Hot inclusive \ CLINICAL FINDINGS* VS. EXPOSURE TCP Runaway Exposed In* 55) iX 32 50.18 0 0.00 41 74.55 6 10.91 0 0.00 1 1.82 5 9.09 1 1.82 0 1 1, 0 14 7 0 2 0 4 1 0.00 1.82 1.82 0.00 25.45 12.73 0.00 3.64 0.00 i7.27 1.82 .Other Exposed ~wrrr l% 43 55.84 0 0 . 0 0 :1 i ii 52 67.53 l 12 1 5 . 5 8 > . i . 0 0 . 0 0 i i** 1 . . 1 . 3 0 M mi 6 7 . 7 9 i, VI 0 0 . 0 0 i i ii * 0 o'. 00 1/ 0 . 0 . 0 0 u hii 5 1 6.49 ' 1.30 I . i 24 ' 31.17 1 i > 13 1 6 . 8 8 *i r< i 1 Ml 0 0.00 i Mil 0 ` 0.00 j i n 1 1.30 5 6.49 1 1.30 ,r ' ' i V' : j , ...\ CO a o c Finding Lichen Simplex Chronicus Lipoma Melanoma, impression Mi 1laria Neurofibroma, multiple Poikiloderma Psoriasis Rhinophyma/Rosacea Squamous Cell Carcinoma, impression Xerosis Nervousness/Anxiety/ Depression Systolic murmur ** Diastolic murmur Decreased libido (H/0) H/0 Impotence, NOS CLINIj4?E'L FINDINGS VS^ > EXPOSURE .i i` TCP Runaway Exposed (n= 55) % * / 1 1.82 ; ! 2 ' 3.64 0 0.00 0 0.00 1 1.82 0 0.00 1 1.82 0 0.00 0 0.00 - 0 0.00* \ 12 21.82' 7 12.73 . 0 0.0013 23.64. 9 16.36 * Not inclusive ** 0.01 < p < 0.05 for comparing TCP to Other Exposed Other Exposed (n=> l T V ~ #% " 3 3.90 1 , 1.30. 0 0.00 0 ;0.00 0 0.00, 0, 0.00. 0, 0.00, 4. 5.19. 1 1.30 % 1 1.30 1 13* 16.88 ' 4 1 1.30 ft: 0.00 i* 24.68 7 1 9 09 i . . I# I I I'I f'' >v , A Lr * ** r ^06>>2 Serum Lipid Cholesterol Triglycerides LDL, estimated HDL EXPOSURE vs. SERUM LIPID FINDINGS TCP Runaway Exposed , n #(%Abnormal) 54 5 ( 9.26) 54 8 (14.81) 54 5 ( 9.26) 54 9 (16.67) Other Exposed n H (^Abnormal) 75 3 ` ( .4.00) 75 10 (13.33) 75 4 ( 5.33) 75 6 ( 8.00) \ Probability NS NS NS NS ) { Serum Lipid Cholesterol Triglycerides LDL, estimated HOL Smoking Status Never Former Present Never Former Present fftr..' EXPOSURE vs. SERUM LIPID FINDINGS BY SMOKIfjG STATUS TCP Runaway Exposed n ,l #(%)Abnomtal 12 1( 8:33) 24 2( 8.33) 18 2(11.11) 12 1( 8.33) 24 4(16.67) 18 3(16.67) Other^Exposed n f(X)Abnormal 15 0( 0.00) 35 1 3( 8.57) 24, 0( 0.00) i 15 2(13.33) 35 , 6(17.14) 24 2( 8.33) 1*11.1 *1111i>, Probability ii N.S. II N.S. N.S. n N.S. ... N.S. N.S. Never Former Present 12 % 24 18 1( 8.33) 2( 8.33) 2(11.11) 15 0( 0.00) 35 3( 8.57) 24 K 4.17) N.S. N.S. N.S. Never Former Present 12 1( 8.33) 24 4(16.67) 18 4(22.22) 15 2(13.33) 35 2( 5.71) 24 2( 8.33) N.S. N.S. N.S. 2i Pulmonary Function Parameter FEV1 FVC FEV1/FVC MMEFR EXPOSURE vs. PULMONARY TEST FINDINGS TCP Runaway Exposed (n= bb ) I (%)Abnorma1 < Other Exnosed (n= 76) I (X)Abnormal Probability i . .i' 'if . 11 20.00 . 18 i ' 23.68 N.S. 12 21.82 20 26.32 j 15 27.27 14 18.42 it N.S. ii I. N.S. 17 1 30.91 22 i . 28.95 H li N.S. h \ I >I ii u II * V. Pulmonary Function Parameter FEV1 FVC FEVj/FVC MMEFR L Smoking Status Never Former Present Never Former Present Never Former Present Never Former Present EXPOSURE vs. PULMONARY TEST FINQ1NGS BY SMOKING.STATUS TCP Runaway Exposed n /"HiJAbnormal ,v l i l(:&.69) 24 4(*.67) 18 6(33.33) 13 1( 7.69) 24 6(25.00) 18 5(27.78) 13 2(15.30) 24 5(20.83) 18 8(44.44) *. 13 2(15.38) 24 6(25.00) 9(50.00) . *; Other Exposed n If((Abnormal 14 36 -y i `M 36 25 < 2(14.29) 6(16.67) 10(40.00) 2(14.29) 7(19.44) 11(44.00) 14 1( 7.14) 36 6(16.67) 25 7(28.00) 14 2(14.29) 36 9(25.00) <25 .11(44.00) / Probability N.S. N.S. N.S. N.S. N.S. N.S. N.S. N.S. N.S. N.S. N.S. N.S. * ro CO o3. a o EXPOSURE i: ca vs. \ ECG FINDINGS' . i < in Finding , rt' ' >i Normal ECG* Negative ECG* Sinus Bradycardia Sinus Tachycardia PVC`s2 PACs Atrial Fibrillation Intraventricular Conduction Defect Left Anterior Hemlblock 1st Degree AV Block Right Bundle Branch Block, complete' Left Bundle Branch Block, complete Old Anterior Myocardial Infarct Old Inferior Myocardial Infarct True Posterior Myocardial Infarct Digitalis Effect * : TCP Runaway Exposed (n=55 ) .% 9 16.36 1Other Exposed Cn-77 ) # :i % | * 30 38.96 25 45.45 ' i 46 -i 59.74 7 12.73 0 0.00 3,:. 3.90 1 1.30 1 18.18 1 .rCoO ; 5 . , 6.49 4 11 5.19 1 1.82 2 3.64 ; 0 , 0.00 1 - " 1.30 1 5 '` .9.09 , 3 ' 3,90 0 0.00 1 1.30 i ' 1.82 ; f1 1 1.82 . i1 } ., ,'i 5-19 1 1.30 1 1.82 1 1.30 3 5.45 : 3 3.90 0 0.00 ` 1 1.30 2 3.64 : 0 0.00 * Normal or not significant findings i> 0.001< rt.05 * p <0.01 for comparing TCP to Other Exposed ; 0.,n for -- par'-- TCP *" Qtu"r Exp^'^d Finding Left Ventricular Hypertrophy #-* ^ Right Ventricular Hypertrophy Left Atrial Hypertrophy Non-specific ST-T Have Changes Low Voltage QRS Abnormal P Wave Left Axis Deviation EXPOSURE vs. ECG FINDINGS TCP Runaway Exposed 1 '3 0 0 2 1 2 0 * 5.45 0.00 0.00 3.64 1.82 3.64 0.00 \ Other Exposed W lT ) l* 3 3.90 0 0.00 1 1.30 4 5.19 0 0.00 5 6.49 1 1.30 t V v1* 237907 (f EXPOSURE ;; vs. j :, CHEST X-RAY FINDINGS^ Finding Normal Chest X-Ray Evidence, Old Granulomatous Disease Evidence, Arteriosclerosis Evidence, Degenerative Bone Disease Cardlomegaly Mass Chronic Obstructive Pulmonary Disease (COPD) Aortic Aneurysm Pulmonary Hypertension Blunted Costophrenic Angle Acute Parenchymal Disease % Elevated Hemi-diaphragms Pleural Thickening Parenchymal Scarring Possible Mass Aortic Valve Disease Trauma Runaway Exposed In 55) lX * 14 25.45 : 23 41.82 11 20.00 ' 8 14.55 : 5 9.09 ; 2 $.64 2 3.64 ; 0 0.00 ; 0 0.00 6 10.91 0 0.00 4 7.27 6 10.91 ; 6 10.91 i 1 1.82 ` 0 0.00 2 3.64 Other Exposed In*'>7) lX 28 36.36 26 33.77 12 15.58 ;6 7.79 3 3.90 1 1.30 5 6.49' 1 . 1.30 0 0.00 9 11.69 0 0.00 1 1.30 7 9.09 4 5.19 4 5.19 0 . 0.00 0 0.00 CLINICAL LABORATORY'FINDINGS vs. . exposure: status BLOOD Calcium Phosphorus BUN* Creatinine Uric Acid Glucose (CS) Total Protein Albumin Globulin Albumin/Globulin ratio Total Bilirubin Direct Bilirubin Transaminase, SGO Transaminase, SGP Alkaline Phosphatase M om olron to TCP Runaway Exposed n "itiAbnormal) V,' .53 52 53 52 53 52 53 . 53 53 53 53 53 52 52 53 52 53 0(0.00) 0(0.00) 5(9.43) 1(1.92) 3(5.66) 3(5.77) 1(1.09) 0(0.00) 0(0.00) 1(1.09) 0(0.00) 3(5.66) 2(3.05) 2(3.85) 2(3.77) 3(5.77) 1(1.89) > 8064JC2 0.05 <p< 0.10 for comparing TCP to Other Exposed Other Exposed n 0(%Abnorma1) 73 0( 0.00) 70 1( 1.43) 73 1( 1.37) 73 1( 1.37) 73 3( 4.11) 70 8(11.43) 73 0( 0.00) 73 0( 0.00) 73 0( 0.00) 73 1( 1.37) 73 0( 0.00) 73 2( 2.74) 70 1( 1.43) 70 0( 0.00) 73 0( 0.00) 70 5( 7.14) 73 0( 0.00) I ,a'J ;-i to - ** V 237903 1 S CLINICAL LABORATORY FINDINGS vs. EXPOSURE STATUS ' Sodium Potassium Chloride G-glutamyl transpeptidase Thyroxine binding globulins CBC VIBC RBC HG8 HCT MCHC MCH MCV N Differential Poly io Co^Ph S0 Mono Eos , Baso Runaway Exposed n ; T(3bhormal ) li,F >#3* 2( 3.77) 52 0( 0.00) 53 1{ 1.89) 53 4( 7.55) 53 12(22.64)' i 53 3( 5.66) 53 0( 0.00) 53 6(11.32) 53 7(13.21) 53 20(37.74) 53 6(11.32) 53 28(52.83) 53 1( 1.89) 53 2( 3.77) 53 1( 1.89) 53 0( 0.00) 53 0( 0,00) Other Exposed n f(^Abnormal) 73 0( 0.00) 70 2( 2.86) 73 0( 0.00) 73 1( 1.37) :74 16(21.62) 73 2( 2.74) 73 0( 0.00) 73 7( 9.59) 73 9(12.33) 173 28(38.36) 73 n d ^ . s i ) 73 30(41.10) 7 3 3( 4.11) 73 3( 4.11) 73 0( 0.00) 73 2( 2.74) 73 0( 0.00) l*