Document baQnng798dZJka8pZ9m7kpmDO
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Feces3MMPerMothtoEocdDoDIlCfeoAvreLSlotDpumEdyPeAnNtRoM.TTeMt-Da6Eb3eNo1ril6Tvis.a,1mtC7iv,OSeTtsRu-.6Pd2yO9fSRo.A2r1PT,eETrf-Tl7uO1o3Xr2oI.o3C;cOtSaLTnOe-4sG1ulYfonatc
SFfTetlhcuuieodssrysimtnuOeedbtAyajebniscoatlldiyivteteesi:ciaganlnaCelydhsetiosm. gisetnryerTaeteamspteociumseenfsofrodretvheelo3pMmEenntvairnodnmvaelindtaatliLonabaomraetothioyd of
Research O ient: 33SMMainCSt pPeenacuteilar,l,MtyBNuCihl5de5imn1gi4c42a3ls6Division
Sponsor:
33SMMainCSt pPeenacuteilar,l,tMyBNuCihl5de5imn1gi4c42a3ls6Division
Study Location: 33SMMainCSt tPernaautteelrg,,iMcBNTuiol5dx5iinc1go4l42o7g0y-L3Sab-0o6rartooorym SB314
Study Director:
PAT33SMhMaoni.xdn: iMCrt6ceP5oewena1ldou-tMieg5clr,y7a.,Ml5BSSD-p3Neueae1ilpcc56dtai51i.atn1,l/igF4sPCAt42ho2XDr0p:-.o26rE5a1-t0e-72T3o3x-1ic7o7l3ogy
Study Toxicologist. PDA33SMhMaed:iavnn6MCatn5nPeea1cnade-Lut7ideclu3r,aR,e7MlbBe-D1ksNue3eeiarlp75d,rt45ci.Mnh1F/g4SACT42Xoo2xr:0pi-6co2o5rEl1ao-t-g0e7i23Ts3to-x1i7c7o3logy
ProposeIInnd--SLLtuiiffdeeyESTtnaidmrtDeDlainateete:::WMeodnndeasdyaNyoNvoevmebmebr e2r22,149, 919999
RTpTroheogxitsiuocslcotaoultoldogayrynywdLCilcaollbabmsGespipLlfieiaPerndfPocarreoms:gaerda"mCinlaPtshrsoeBc3eMdSuturSedt.yra"teagsiecxTploaxiniceodloingyTLOaXboSrOatPoi0y9u5n0d, eSrtraadteegfiinced
000146
T-6316.17;T-6295.2I; T-7132.3; ST-41
DfuTarennsitHsMhaeIkaddeteehsr,nigiPtahilrf'-o.iNpcduaaurtmicitotyenR:N:e-sEptoFnOsiSbEili,tyPFLOiaSisoannd3PMFOChSeAmtiocatlhseDSivtriasitoegn,ichTasopxriecvoiloougsylyLab.
2NPp7eF-r9EOf5ltSuF-3o:O9rPoS-e3oErcf:ltuaNnoaerrosruoolcwftoanRnaeamnSgiudelofNoen-tEhicathnAyoclli,dF, MPo-t3a9s2si3u.m Salt; CAS #
PFOSA: Perfluorooctanesulfonamide
Molecular Formula: N-EtFOSE. C8F17S02N(CH2CH3)CH2CH20H PPFFOOSSA: C: CFgjFtOi7SS0O2jN^H2
Lot Number: Non-eEtsFaOmSplEe.: Lots 30035, 30037,30039 mixed and analyzed as PPFFOOSSA: L: Lot-1#0201079
Purity:
PNPanFFdEOOtDSFSSAO:C:S>tE9e9:c%h9n8iaq%sudeaesst(ed1rme).teinrmedinbeyd1b9Fy-GNCM,RG(C2/)M. S, 19F-NMR, ^-N M R
A99n%alypsuisreby(3G).CMS determined that the staring material was over
tbmfc(QhIrhrsouoaaaomnntaipnlcotirh)thtmo,hae)1pteeiac8ytvsnho.le7idymnb%algr0pnbal.oeCdnr2asc8tFqinrh%ti3ucia)o(ah,lCn(n)3`C,tHFw.1i5tF21aa%/)^s.tsx2ik-v6-%CNCCe5x^F.cM(8FCoC(%2CmFRFxF3pC^+3c)o-l2Fr)sS-o-CCi3(tOsC(iFFsoC^--F(ni(FCNn2aC2lt)FHeFy)r3gxe2-^S)r-s)-aStux0S-t0l-B2i0tSo2s-2unN0-t-Nth2NayH-anHiNH2tab2wlH2(ryIa(se2n(NnirAtsceeohlrrrpdeXnmhvea4raeali)alv.leedd
iHpc9CCmop69hPnmpMFL%cui9CeroiSn(S/tf5Mi0tPer)2Oa.sFSN,tOitojHchNSnhe2,sHa,pr61o*au,,fc16r1sti00ete,y002rvi0ezpop0rappfatmmptilhopoenomothPfofeFCoCfrO7tf*haFCFSme18iA56PiFSdHFiOse5SOasH2m0.NS22BSpAHNa0l2eHs2s,ewaN25dm,o1H2opu024nlledp,a0tpnhrb0emdee0vlseaopouappwfmlpmeerdoorox9ffi,tm6h0ea0tely
000147
2
T-6316.17; T-6295.21; T-7132.3; ST-41
tICSTShntetehfoasoabtrtrearmimaslgitcaaetytmtteieC:orraniDiotasenltooridiwcncaiusltismli:wylonbeniltneslht:besatsetoiioskrenemdpwetttiiohlglnohbdtfelsiyl,eksc.eeopamtleopdnoasfititlireoo.nomortoemthperercahtuarrea.cteristics that define AnimatIWNASSSsd:optguereeueamnicrgitacinibehfte:esit:GGGGic:rnaaRRRRaitttniOOOOiioandUUUUntiits:SRHPPPoPieaupnaxa342t1nrtri::.:a:oloiaqgPPNcfnnuuoFFt-eernoEOOe1ttftaar2DSStoitFrAl,mmaleO,nwma,ae=nSntllan=ee3m=rEys3tk3:,enn=t:3 a9p-1p1rowxiemekastely 200-250g H usbanDHdiroeyut/sWintHTAaghal:earltlloeokrrlwnluaaagndtfsh,oTowMreuciklatolldtalbhlidseeeocLisntniMt,oudWndi-v4yoiI8.d,f5uauanMrlildnyotehuaaospneuw/dsReafadettecirenSswtw.eirliilrleibzebabopltretooDvmiidemet,desttuaopbapolllliiesrmdatbscyaagHdealsirbltaiotnum
EnviroEnmnveirnotn: mental controls for the animal room will be set to maintain a toefmropoemratauirrepoefr7h2our3anFd, ahu1m2ihdoituyrolifg3h0t/-d7a0r%k ,cyacmlei.nimum of 10 exchanges
Dose anMdeDthoosdimuvsreaA1neoaso0goslcgilcll0iniefu/hPndrmgimamagsvrsdtLolaeawesgemcm)/a1wioek1lai5pldfs0gnin-llibu05dilemndserbgmmiotPelsprelssteFalgeid:edstOdr/4riskofoooa0ouSgswfsn0reeiPm(d/ndn2mgDFog-e%rvuOsgiodisenp/a;suSkdwoe2isAogenpi0frprt.dePa.thrmhnolFeUe5sgsRgOpienaos/saemSivytnofr-raorsaoLfa/igurntNnkm)ikesgodewpg-eosnEesrinbfuanl:otlootssdfFsbrpditaoOeeihydynnnoepSwzsgsorEtieieeironf,sropinPgosgruasua.hFrpoettoeOs.fd4gfStiRNrhniwineanag-in2Eldtsrlsdo%ettruirueNFndcppTOy-geeEw3irSsuvotteEswFeeuielOnipna(lbg8lS2es8%raEife0nwoc;grei8elliel0ve
000148
3
T-6316.17; T-6295.21; T-7132.3; ST-41
gbrTPfAaeoycaFwcrevsOmpeetianoiueSgvignmnneAelegep8t,2o(ai05%2n2n.%rg%maeTttml;hTsw/2euwiek0nleesegmgmineobrnngu8oo/l08udmisn0piyao.L2nnw1)%dRtoewhei1ngrTi-lowshldwuutabislegydelpehorzenpesnterche8erseeopi0oioavsfotnreoyveforaedtaihfnhmbfPegiicyneFilsxaetOdiutlmiwudSscrmsyioAelo.lnelobsvTdcfoeeiiwnal1niatg%odetdrlsiaomynatwfibciaontieechlniltfeseoobottneorreferaenep1/ted2dse%,o%rwvtsfhoiiinaelrlgnmo.readl ObservaFCBtrloieoidnqnyiucoeWaEfnEOirlfomAeiebcOananminyscmcdegbehhiaimhraenscivndaeangtoseanniirsdnna:dvilitwmmtsg.areN:otliaaayliullllnomapbwwinmnresiibidllao:rllelerosbbrcnteewoooeworfidlePbAleueFsbindtegOhe.irhamvSsAeneaAdaaddclsridsrimdia:iafati.timciolweynedidafllilooabfrntieenmdldysaoiaynprctgrr2aiisl-ofipiwtrcyoetiolsdaltnbtodrdeenomarsdetemoac.yroebrn1iddtepiatdoynsadatsndtdohseneyo.taaArbellel Specim MeneCthoolldtwEfrUoAtwasaawna5eererennlnecafaomoinimirmapadcqldtlnctizilifltlnharmopuhoseiyecotbbSrneefewnorvnsaepaeeesupirteauantlsersaoit&eesradnnwrn.ertyrtecreliadudwspl,linciaAlidaEo.flriomboensfliutbqewTnlaheastlrdlbgeu,ceoocmctdaehelbeeionahoeesedddlebdfepnyltsddudoilloCllnssndteiseoweasopveri(faiceouegsoett*orowelitdhr:.ltucadldirrolhlvloe6liimyeflonwgTaebaocnlopccmnateteolhiattrwrulacnlihfi-looetlzlcommlhpo7.)iepeteb2olinpr0nAlwcndyaeewe0l:abatlnitlb0iieotaberiCeseiloilacpeml0nbaymxlfntttelbeocubufderxaCaroteavlidresilmiulisv.Oinogolrtecnwbesfisidlsm2dordpectuefeioaolereulsmoaacewlnlmodrennnttfrwabrfeiacieddeuioll1debtenymlidogen5tgoawosbtwhdefoocwirtlt(eoseouioohavatvt2uinurrsesapegimeli3thsbnaapnahiacan0eadbenlreeentonindohetdeqaamarytawtxlehc.dlwuniebycciririeeoTddmanoeloseoildbttimulohnpasfhsia1b.dtrs,ett.gst.eaeorhom55eytuDislirzTemlfi-nrlaympvu1eearaacihniennegci0ntfa3nlelsrrgooeyrtgamiffm.ogrwnrroleearefdBorierrlbeatimadcomermldlciodmlrer1ondoeaoyeredbb1co,sitsifddnehal0oidtu)towca.hedo0ngfaweyosDemleiene.axaszdairiduslsmiegtlocgwOihucrddhabnipebinnfetlelelloellseegssrs.
blsiaqecusriitdfoircneeidtdroaogtne-7dn0afyoCr2f-fbpotorusbrteiodbcoihsoeecmhweiicmllailbcaeanleaaxlnycasisliyse.sdiK,s.wideniegyhsedfroamndafnlaimshaflsrozen in
000149
4
T-6316.17; T-6295.21; T-7132.3; ST-41
SpecimAtaeennlmlalHupyrosaiirnnsae,drtialhliynnedsgset:foesrcaeemds paaltned-s7wt0hielCl sbeienruptmhaecakSnetddraiitinevgedirrcyfoTircoemxaiecntodalbosoghlyiiptLepaeabdnoatlroya:stoisryw.illFboer
TK39SM3ter.5liesPEpBaHnhuuavolsn,inhrsMoeeAnnNNmv,oeP5e.n:nh5ut61eDa35l.31T--37e3c7h381n-6o0lo8g1y,
and Safety Services Facsimile No.: 651-778-6176.
tAhlel kSitdranteeygiscpeTcoimxiecnosloagnydltahbefroermbaioincdheemr oicfaslearunmalyasnisd. liTvheersweisllpbeecimkeepntsin will be stored at -70C.
Tfohlleownusm: ber, type, and date of specimens to be generated for analysis are as
TABLE 1 -Sped m ensfo r EnvironmentalLab
S pecim en
CoDecti o n d a te
Day 1 post dose Day 2 post dose
Environm ental Lab Specim ens
Urine Feces
12 12
10 10
Sera 2
10
Liver 2
10
SSptreactiemgiecnTs ax. Lab
Sera Liver
2 2
10 10
Kidneys
10
Total 22 22 12 12 12 12 10
Data Analysis: All results will be provided for inclusion in the final report.
R esDtpciosoeslnaluensecinbtsaiinplLigetciuieinemsb-:lekifneesrsfaponerdcaiAmnaneldynrssei,sw.peSrfeoarcmatinwgiltlhbeenreecsrpoopnssieibsleanfdorcdoollseicntgintgheanadnismenaldsi,ng ArenvdierwewbeSfeoarceaat wfinilalldrreapftoartfiisnaislsrueepdo.rt and ensure the report receives appropriate 3M
000150
5
Signatures:
DSSetru.ndiAoyrnDdRriereeswecatSorcrehacTaot xicologist
Aj)u-wn.aL.
ADStdeuavdnaynnTaceoJd.xLTicuooexlobicgkoieslrto, gMisSt
T-63I6.17; T-3295.21; T-7132.3; ST-41
Date
) i gV/75
Date
000151
6
T-6316.17; T-6295.21; T-7132.3; ST-41
References: 1. PayfT8e1wr6,o,R6Y./C2e3ah/ra9Fr7ae.cet3deMirnizgSaStMiotuDndyoL.faFbSMMB-uD3d9dA2in3ng,alM2y3tii6xca-tu2lrBRe-eo1qf1u.Lesotts#5320408395., 3A0n0a3l7yt&ica3l0R0e3p9ofrotr# 2. KesLStnpaeberc,otTrrao.tsoFcrloyupo/yrSoRcMheMeqmuDeisc-ta2l#3I65s-o32m0B3e-01r.1D3, iMDsterSicbepumetciboiaenlrtby1y,A11d99Fh9-e7Ns.iMveRs &SpCehctermosiccoalpsyA. nalytical 3. Payf5e9r4, 2R6..GRCe/pMorSt 9an/2a4ly/9si9s.o3fMPFSOAS&AC(LL-a1b0B00u9d)d.inSgA2&36C-2ABn-a1l1y.tical Request No. 4. LKSapebestcontrreaort,socTroy.p/CSyhMRemeMqiucDae-ls2tC3#h6a5-r29a4Bc2t-e61r.1iz3,aMStieopSntpeoemcfiPbaFeltrOy2SA5A,d1h,9eL9s-9i1v.0e0s0&9,Cbhyem1HicaalnsdA1n9aFly-NticMalR.
5. CDC15hoe8rRro4po.mooRraasettoFqeg.uArCeansphtahal#yryatAiGcct-aer1olr5iuTz1pae2.tc5iho4nn.ooRlofegPpyFoCOrteSn1At0e/Sr7,a/9Bm9up,dlaednsin,dgTL-2e70t1t1e3-r21a--1d2d9(e,LnC-d1Au0mT0C0t9o-)raenpdoTrtN1-0A/1-4/99.
000152
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