Document baQjVx0y2rgkRJgQq8Dg82086

rcoo 000218 HToaxsikceollloLgaybaonrdatIonrdyufsotrrial Medicine 1090 Elfctan Road Newark,DE 19714 Date: To: Cc: Subject: Septem ber 23,1999 Barbara Dawson C-8 Surveillance From: Robin C.Leonard Epidemiology Prog I have iooked at the results o f the first sam ple of measurements from the C -8 surveillance project at Cham bers W orks, A s would be expected for base-line sam ples, there is very little analysis that can be done at this point It is possible, however, to note a few things about the distributions of the measurements. Most of the sam ples had no detectable levels of fluoride ion. I think this indicates that we can assum e a baseline of zero for fluoride ion in this group. The sam ple measurements for C-8 ranged from below the limit of detection to 61 ppb. There is essential^ no difference in the average measurement of C-8 for the operators, m echanics, and lab tech s. The standard deviation for these groups, as well as the group a s a whole, is very d o se to the average value. This indicates! that there m aybe fairly large variation both between members of the group, and between sam ples from each individual. This underlines the importance of obtaining several sam ples from each of the study participants so that we have a better chance of understanding the sources of the variation in these m easurem ents. This will be very important as we try to follow the disposition of these compounds throughout the cyde of cam paign--non-cam paign periods. it is very important that we not overinterpret what is essentially baseline data. The design of the study requires that we wait for the the longitudinal (over time) m easurements, both from tire workers and from tire environmental assays before we try to reach any condusions about exposure compliance issues. I hope this is helpful. P lease call if you have any questions. c m w j r t W l > n* , * ' SC* C a 000219