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: DEPARTMENTOFHEALTM ANDHUMAN SERVICES
= AR 486 13 ee "
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andHoan
4C878oColcuOmbHh4P6a2er2k8w1as0y s
July 31,2001
HETA20010235
PACE Intemational Union 3340 PerimHielltDreivre
Nashville, Tennessee 37211
Hee als th(NIOSH)SfoornaHeea1ltYhHuaezrarsd tEvalutahteiNo eon!attsfor OscrpatioaStymd
TtCapponi acd(PFOA) eo 3MCorporationin Cottage
perfhoroocna(neHHsIu)l.fYoonuer(rPeqFuOeSstmcaomnceegrnm edexe posc ureto
bloodflucridelevels. pro
$10heGarltohveef,feMcitnsnweseortean.o`tTehde.rTeqhueesrtesqtuaetsetdptphearteeamtplloyees
hadelevated
tegeems regain recent sittin of cgineringcoro
y smdfn
and hy spe
=
rea pa
2uipment(PPE)amongemployees | conducted teephone iceviews
inthe w
lorochemicldepen
In
responseto
paroment the loa ion presides,mdtheDiirtehctteo oSfufOyoDcpiatonosEeomeepcee
.
ein.This lets summries the finding ofmy eval
`addressingyour concerns,
sndghee ce
ion
Background
.
3M.CotGrot ve,aMirg mesoeta
.
MSepateia alsMayrkietns GCroonugp(rGervoivoeubsoysksneossweveral divisions,an fics heSpecialy
Operions ar
onepar ofthe
Specialty
n a theChemialDo, MaterialsMarkets Group.
`The fluorochemical
rove Grovein
sempefrocanosc (APFO), yh fi
.
1947,APFO
dissociates
rapidlyinaqueous
salution
to
cs, pai Cotnge PFOA.APFOis a white
Pe om wdee m r prol s ducecdeoblnylvsearenteeddletcotsroschtecmaikcea,lwprhociecssi,sdItiisetshednipsoalcaltegdeatnde conver rtedtg o asatshury,
S peci kagir ng oe fAPFbOvsetip ll oich ctuhresir pnrtohde ecCioorn tnaogfei GArPoFvc Oepsla(nntF.lOOotSnhgPesrsfmluionrogchm micalsmp anufactured
similarto that describedfor bodyto PFOS,Fri
PFOA.
Thesecompoundsare
4 ress
transformed afterabsorption
naeyproduction of FOScompoundshasbeen
at
3Mflies
in
in the Ameer
000080)
. "idiggs 3MCottageGrove. HETA 20010235
Page2
Beoplegraituimona.ndTheDreecfaotruer,, pAulbalbiasmhaed,liwtietrahtpurreodruecgtairodninin
Cottage h
Grove
beinag
much
smaller
produectdiownowrokrekresrfsoams wAelwl.eFPo idDeca, butshgouealldtbheefa fecp ts oa fPFtoOSCohmapveepriemanrilysr
bowthhPaOSmF anodpAPFOproductioSn aPrperboeduicntgipohnawsaesdroeuctebntyly3Mt,opTpheedreiatrheecDuercreanttulry city ang
20 workersinbuilednineg2r5s,winhbiiclhdtihnegPO1S,wFphriodcucsttihoenmaariesn.APFO production ing an 101
`wwoorrkkers.possaicciapltmirovneilelsainncthaesmbedeiecaplersutrovmeieldlabianial ice he 1970s on focrochemen
i pe vitalsigns.
rmaisseroumfftcmerdicalleveelssw os,prnocespero,gr
ring he 15008me So chmiony pe,were
becameavailable
to
analyzeserumforspeecriefmiecalsnuorreodchetmilctahley arly
19900whanaps, t
.
: Trl.
no od mati
elsinCong gmt
GofrLoLwpepmmploy19e9s3r,agoemdf0o1 m08pas pe
illon (pywith
FL een of 1.3 ppm in
of 12pm a 1995, ndfom 0.1.81 1997.2 emPROSlevels inw
pms, wi1t4h.a1ppperwfily4peeess aereg
175poyes eng fom 012.8pp (omrekmer2s.i19no3Mm'sAnt1w9e9r5ps, dBeOlg5cn5,p ande Doe me:
1.o75rpopmle)vienls1i9n97t.h>e evaeel ]ipn o3Mpelmiplnoyreserseipnocrotredp1orarteenogfeifeosmav0 era.ged130.05 pron Sern
Health Effects of PFOA
aondnislnostumeitasbodleimzeodn.suttiestehliamtiPnFatOeAdpiriambasroirlbytedhrby ingestion, inhalatiion, anddermal exposure .
estimated half-life of 18-24 monthsin humans andLeydigcell adenomasin lab a
PFOAouignhcrteheasuersitneheainndcfiodceunsc.ePoFfOliAvhera,psaanenress,
elevationsincholecystokinin.PFOniAmaallss
levels in rats?
ed mark
1i2nTchreeapsaencersetraatdiicoaldleevneolmsaasnmdadyecbreeadsueedttoesmtiolssdr
pecross,
changesin
lipidmetaebdolhiecpa,tincdefreodtuciendalneivmelaslo,f
ching ida'
vercampeon
one er
positive associationsbetweenserum fluorine levelsand estado)prolactin,andthyroid Ffaeciilnitywuthielinziincglboigeaineisalumeidsicbalvsubrveecillacnocnedducutteyd
on C
PFOAworkers
he Cong Grove
reatdto serum
PFOA
levels,
otelevateda3seen
holecystokininlevelswereinversely in anime)sadist`Whileonestudyfound
emaling re apm
hormone(TSH),and the idno id
negative relations significant elut
beens owsaes
.
tchheolseesbtoerromlo,nheisg.h!deJnisliitaynldiptopnrdoMtaeinnd(eHlreportedthatiinnsuhniadbjuesteednansaplyasmesP,trotdvpel,s and
oloasnsansamiamnitnee(SOP).grams DgL)a,ly owdaennssittiysleip(opGroTteion(rLsDLo)r,ssep rumsglutamic
found no evidenceosfad(vSeGrOseT)eweprioeftoccotrserleliedw0itextpolssewe porp e tc.
000031
3MCottageGrove. HETA 20010235
Pages
opAertreitsordoso1preacl9tli-vc4eacuso8ewhmoao-rsrttpa1emlrif9tooy,r7rmcae8ndtsc?teruTa-dhsypiolescfiiCnfihiccelmtmuodirecaydalbloDtihviAsPiFonOwaonrdkePrOseSmFpalorypeaddurTihnegtrheewatsimneo
boa oftn1s0ye,arPs OTAh1is1wr9a8s3beavseednoend 4 pcrocstasteocfapnirctoeyrs,doearctahnsayioestthheoerecxrapuolsseoerdffneagtbss,AnAufpudrattheer
oloowree aa s doosresrSespioanlsyekorseolrapotugohs?19Mn9orseaveletsyintse0eserfxtocreaoslvpsaoivsnstienscdoefcormen is"gh
rthan expectedinthegeneralpopulation.
ay arp
HealthEffectsofPFOS
a
deeesctrisemaastoeeeddhesaetlrfrulaimtfceehionilsneetstrheuermloilovleferv1e0ld0sis0-so1de5mx0ec0rtdeaatbeyodsliiicnwbhaoustmthathneswiEnxepoasndurfeoiensan?iPmFaOlsSrBesiultasin en
poppasnentotserenvealPaEiOsStliecvaellys Teo 26Pm, hereon it was
gitaannt6pcnha.ngeViiynngfh?weAcstmtpusdleyoyoymfeosPsF,p ObS pros odunctriyonatters
ot possibl o draw conclusions epingepson
D1pe9o91iitahlntacatmoesrtaeuldiytyorfwilooerwskeeswrefsroreasplalltcoiasytiecraislnytshe Agbnnllowdhinyhe
ped ern
1961.
:
Sgpreenoenrcahluppsoo,punladtitoornnac.gh1esr1,9oh9mo8yw,eeavvenesdr,t,teislelcevastimonowraaslncootmrbeisnewdestaicrlyuetslislvigniigfniciaotnerts.sCosbonrotmeohreteialgi,t,y
stabtiseticdalltyosiSguniofrioccahnteliycealleveatxedphreoart,eew.Tbeheetachurctechedooerpasdttaohtsnefldtohxamtpbliotawsdad,seuronccamlnecaaegrr,ifrtehietseicnagsnesncanbe
Exposure Criteria
eel
weVhiageluhAetme(edTraLivVcear)nagfCeoorn(fATeWrPeAnF)c.ieO2osfT0hG.e0o1rveemrinism0le0nltNaiIlOgpSIenrHdruRacsutmrbiisaclmeHtygeireonfisatirs((mAgC/Gw'I)Has)aTnh8r-ehsohuorltdiLrimmei-t
B`eEpxpaosseunreenLtiomiftL(aPbEoL,)OfcocruApPaFtiOo.naTlhSeafeextpyossuordeHleiamlietthfAodcrmPsOioSoFrsamEetxtipbomoynsu(3erMoeisLnitm0i.d1tp(mRgeEo/Lm)d,oer 0.5,
t23o0ph0o0s.e9snioppeotaiwnsiOcdlepofgiinaecdalasfthdeBbiehslattgeesptraetseeitno,VfeaveleeveGlLoYf)a chemicalsubsPtEaOn
i taco ct
epeeaporsotfo,rorroocuotrirneels2auter4vvie1tlh0a,n0acsei,gtbniefircantmriesdkioafladvvereslenhienasltechvehfrofyunctsm,`eoWsnoiir,kweocruslowdimptthsserocuxmpPrcFiOsdA
itarlowed rain nhwerkses one
2
000012
.
3MCottage Grove. HETA 20010235
Paged
deconl subisen queent testing. `monitored.
Workers with level>s 10 ppm areremovedfromtheareaand
3M receatly undertookanindustrialhygiene assessmentofthe fluorochemical
i
epxoptoesmuordeisfaibeodvseotthheatTtLhVeyfwoerrAePrFeOm,ovLendrfersopmontsheetportohceessefirnedaisngas,processoperator'sjob tasks isolated controlroom.Entryintotheprocessareas nowrequires PPndEsctoantsiiosnteidnpgroifmualrl.yfaicea otrhrerrsoupubigbrheuroa,dsde(ecepoietnnhtedarimsniugpnopalnitehdeaaereoar),initprirlyegilnovge,sd,eapnednrduibnbgeor botohtesar,Aecs)c,ecosvsetroaltlhse p(reotcheesrsTayraeaeskis TLV for APFO wereidtenitoinfrieodo,m.sndAalcatrigoenntuakmebner9orfetdasukcsewxiptohspuorteeinntcialluedxipnogseuxrtesaanbtovethe
`heenvironmental sirsamplesin non-process reas ofthe building, ichudin the cou mere
aorveuaes.olsandPPE sinlar to thoseaddedinthe APFO areaare utlizedinthePOSF prodiion
ConclusionsandRecommendations
-
foluiohraoscahenmiecxatlewnosirvkeemresdsitctahlesCuortvteaigleanGcreoavnedfiancidluisttyr.i`aWlhoyrgkiaerneeamsohnaivtoering programfor
rendguicneeecxipnogscuornettroolfsl,upoerroscohneamlipcraotlesc.t3ivMeheaqsuicpomnednutc,taend
administrative
acombination of controls in plac to
-
hfuumeraonchbeeamlitchaelfmfienctisfsatcuudrieisnrgeplraotceedtssoefslautorCoocthieamgiecGarleodxvopeorassruprobene.sMioonregsdatncutimmvpeeoryroptuahnsataslnyei,mtoahvlesaend
`witphosaudrveers1e0hePaFltOhAeafnfedctPsF.AOSnaetptihdeemlieovellosgeinccsotuundtyeorefdPsOtS3FMwofrackielirtseshhasaivenotbeen asociaed
remloartailointsyhsitpbdiectswmcanyoucncduepraetsitoinmaalteextphoesiunrceitdoenPcOeoSfFabnaddbladdercancer,
dentified 8possible Itshouldbenotedthat
Conversely,otherlteratureonthehalt carcinogen. Giventhe sbove, noconcl
fectsof
dercance since POSFhes motindicate
i i oftensey tht 1 1 pip
exposuresto
POSF
and
usion
bladdercancer.
canbedrawn
attis
time
concerning
oosupatonsl
F1ro ecommecnodmthpaltetSMe icnoonrtdienruteocmuroernetcmleedsilcyalascseurrtvaeiinlatnhoeepeotveenntiafer the phase-out ofthese
emPpFlOoAyaeensd.PF3OMSs.hIounladdcdliotsieonl,yf3olMlsohwoauvladilcaobnlteienue
to
alhealtheffetof expose updatecohort mortality snuciesofthese
to
regardingthepotential risk ofbladdercancerinwpoirdkeemrisoelxopgoisceadntdocPliOnSicEa,l`iInnffoorrmmaattiioonn
on thefuturemayhelpdetermine emplwoouly d be euse efusl. -
if
screeningforbladder
cance
amongexpensd
wads
.
000v33
3MCottageGrove.HETA20010235. *
Pages
o1hompeepthoisseinofforfmoartimoinnigsfhelcpfulteomypoluo.yTehsi,scloetpteersferivesstwecplosesthhoeflidlbeofoprrtheisdproject, For
Youhaveanayfuprrtohmeirnqeunetstpiloancse,psleesasseiclaellmtehatc(a5p1l3)o8y4e1s4f3o86.peiod of 30 me os.17
.
Sincerelyyours,
Ei- n7 e Last
. ElenaHPage,MD,MPH
CL H4 lGoFH Haeos ind Tecigk.
eo DivisionofSurveillance, Hazard
`EvaluationsandFieldStudies
-
" gpoo1a
References: TpriermfinloolroOogWoic:ctiGanivnaelcsltiignatEiDon,oBfurrepireowdMucMti,veBhuorrmso7nMe,sMiannmdeenlwJiS,thMaocncdueplatJiHon(a1l9o9n8)s.orAans :to
ciidc. JOccupEavironMed. 400614632. rwoprokepcrese.nnD GzyWm,er asBnu,rcdrhCiouhslIeesmMti,g ecrBoaullr,aiTodxiMlcioMploo,pgrMyo.atne2di3en(il4nyJa:6m0[m32o0.n0300i].u.mPpleasrofaucorhooocmlmcntyspsoisletkveeilrsnssoad heM3p.eadOt.lisc4ea1n(n9Gd)Wl:i7,p9iB9d-u8crl0ii6ns.iIcMal,chMeamnidsterlyJtHe,sZtsoibneliLvoRr[oc1h9e9m9m]i,caSleprroudmupcetriofnivworaoorcttasmeJsuOlcfcounsptEenavnirdon SSuub2mi0t0ed010t,heDUrnaiftseidStialteasssEensvsimreonntmreenpteanlt:PpreortfeuctoiroonocAtgarnsaysu.lfonic aci:dandfsfas. Eo; SrecuyorocbeTmAi.caSlosre-upsroenlSiDm,inRaroyarcehpDorEt.[A1m98I0]n.dHHeyagtAhssstaotucs o4f1p.l5a84twsoprkers exposed SSm 6p8g.protia n,FsDo,dMcan honldeestleIroSd l:19a9s6tu}d.ySoefroucmcuppateiornalilyvexpoosreadocmiedosa.ncAhtepnaationctdcyo)mrieyse,Shes.
BooBomooaapntsJsMe:isMdnemaFcroDedtei[lo19n19,52,U]M.anFnidelvl IueHorfo1M9si9rn8nia)eons.toAhtcnyau.meapaLiand:ceOhmleibsloeltnoo:gGsinWcai,tnvsGieisstilinglaaatnidooFcncDou,fpnBateieoyn!rpsarsbe.s.
40(7):614-622.enwithoupational exposetoperioroociasocile. 3Oaentperiod .
Bogan
producti
FD,ManJSd[1e993l].
Mortalityamongemployees
ofa
,
perforoocanciiod
U9n.ivAerlsietoynoxpflaaMBnitnHn.nd[eJ2sO0eoc0t1cra]u,MSpocErhntovaoillroioftnyPMusebtlduid.cyHo3ef5a(wl9ot)rh:,k9e5r0s-9e5m4p.loyeda 3M CottageGrove cl.
se1l0s.e.MSe,unbdmeil1tJ3Se,dMJ0[ot20h0eh0]U.naRiDAtse[rd1S9aot9a5ftne]s.tMEosorveaislosinmtmeyennstttaurldeypPoorrfpte:cpmceptflohonuyogereeoseotaa:n3eM fplanstinDeca,
U1n1i.veArsliteyovfMaiBzHnaeds20oe0t1ar]S.cMhooroalloiftPyubsltiudyHeoaflwto,rkers employedat 3M Decaturfcily.
Haytg EaOsTe Hygienists.
(a2g0e01n1..
C2i0n0c1iTnaLasV,
OaH:dABmeEriIc:anthCroensfhroelndciemoifGvoavserfmoreentipnuesusbsances
.
13: 3M(2000). Documeonfatnoacctupaitioonnalbiologiclimitvalueforperorsocascati 0.0
