Document baM8ky9KpeO0dZ8D0dRG02Oe3

02/13/2003 THU 10:45 FAX 312 996 1899 UIC LHS CHICAGO @006 130 BONHEH BT AL. Vol 95 TABLE 3 Eespouse or Species to Administration op Dyestcfk Ipjtjcumediatbs SpKies Cbenls&l Tumor Man Dog Cat Ferret Mouse Rat Rabbit 2 Naphthylamine Benzidine 2-N aphthylamlne Bessitline 2-Naph.thyIamine Benzidine 2-Naphthylamine Benzidine 2-Naphthylamine Benzidine 2-N aphthylomi ne Benzidine 2-Naphlhylaminc Benzidine Bladder carcinoma Bladder carcinoma Not known Not known Hepatoma Bladder papilloma Hepatoma, acoustic carcinoma, intestina carcinoma Bladder papilloma Not known metabolites was approximately 200:1. In addition, the dog was found to have a high level of urinary sulfatase, which would aid in the liberation of free 2amino-l-naphtiiol from the conjugates. A consideration of these factors has led to the hypothesis that aromatic amines and azo-compounds produce their carcinogenic effects at distant sites along the routes of excretion because they undergo metabolic changes in the animal body, which, coupled with certain favorable local factors, determines their site of action (Clayson, 1953)." OCCUPATIONAL CANCEH OF THE LUNG Two aspects only will be considered: its occurrence in (I) asbestos textile workers; and (2) hematite miners. The series of cases presented here are, ss yet, unpublished. For published series the reader is referred to Hueper's thorough survey (1952) in which he cites 60 cases of cancer associated with asbestosia, 33 of which were reported in Britain. Hueper also refers to 8 cases with coexistence of sideresis and cancer of the lung. 1. Cancer cf the Lung in Asbestos Textile Workers In 1928, or a little earlier, one of the present authors (MJS) began to collect information and material from the workers in 2 factories, and it will be remem bered that he was early in the field in describing the peculiar hndies and the significance of their occurrence, especially in dumps, in the sputum (Stewart, 1928;" Stewart and Haddow, 1020;*" Stewart, Taltersall and Kaddow, 1932*). Stewart's series consists of postmortem material from 80 perouus who had worked in the 2 factories, and were thus likely to inhale asbestos fibers. In 8 persons no pulmonary asbestosis could be demonstrated, though mnull numbers of bodies were usually present. The effective number for consideration is thus 72,46 males Feb. 1955 Incidence q: Number at ca Incidence of) Average age i Average age I Average peril Total Prior to 19! In cases en * One man f Vigores wob uvailablt and 26 fern: cancer are present in! higher inch before the culosis. Th of exposun asbestosis: in the dye cancer. It cancer tha A fair u Taking in applied tc malignant factory ui factory ft access to developed Two in of the 13 Four wer iicleristic in the pei lymph at these we possibly Raeburn