Document baLaoGRL5G0w6nMexa2kkOm81

AR226~ 3305 487 DuPont Haskell Laboratory for Health ~-- and Environmental Sciences AR246 -- 3305 ofc FROM: J.C. Muslanka iOctober 30, 2003 EQualityMyletArsosetsrtance EST E B: ~ HHMaaessdkkieecllalllRNSeuusmmepbalerercNh(uPArmnobaljeyertc:itcaNlumRebfeerr:ence): `AAnnaallyyttiiccaallRTeepstorCtodNeu:mber: Notebook References: (m2 l| DurGR3-13708 --) TAtotaacahlesdo bietuhseeadnafloyrtoictahlereppuorpt s.sais protosl requirments fo studies with H-24521 but ~ Company Sanltized-Doesnot conJtainTSCACS! TESTSUBSTANCE STABILITYOFH-24921 VS pettles Prn jst Number: fE-mr] . eerolAfa 4921 va dieersd Avg v2a1m,2n0t,esrds sdSab"meoerit4. 20 -- ACKNOWLEGMENTS `Sample preperation by J. C. Maslanka (Senior Staff Chemist) and sampleanalysisby T. Ryan (Staff Chemist). SIGNATURES reponty: BtEuCCoHkdW,es 5-0m Duc lssued: __0-B- aoes a aE DuPont-13708 page 20f3 --~ METHODS pAonalpyseistoaf H-24921 was byonhsigh-epseorifonremsaneccietoleisqhpueirdacehromeatographryshheacsnndogemttmoasls.y lissocaatsodd vai0neorgemandS.anfdorr.agfmonei mnonti Jj SAMPLEPREPARATION & ANALYSIS e E Aliquots (0.e 0233,s 0i.02a70ot,staonedlm0s.o0yw2n5ec2esgaraeabctmoossn)ndosofovH9-233e4592h110o5w,eraraespdi1sor0s1oolpdvoepmd.ionTNhsaensoeopfwuriee CHROMATOGRAPHIC CONDITIONS fp LpCarameters owl Packard el 100HPLC Column: ZorbaxRX-CS, 2.1 mm x 150mm, rsonwi:ena:e: 3HSSppe0mssain ~ CSopon Sk:eren ssteActiAconite ofeorin) A5sceonile aot %2: % : MpmSJaraarmeeneoetseerts o vre De f Biceons i Quatro Mm icroToanmdem iS 41=0 CO 43 rea 0c3oime6nge9r, (daught ermine oeER] oso 8 in pies ~~ -- FE i onc DuPont-13708 pag3e of3 CALIBRATION & QUANTITATION A stock solution of the H-24921 (separate sample used as analytical reference) was `madein Nanopuwrateer. Appropriatealiquots ofthestockwere diluted`with Nanopure si`nawtamtepemlratelosomlauktieocnaslibrationstandardLayssthatbvrearcekbertoeudgthhtettouasrvgaedtdecodo.ncael ntarpaptru ioopnorifmattheeade mioluunt,teod f Analysisof2492M1S/wMSs)b.y hNeiggaht-ipveer-fioornmaenlceectlriousipdrcayhrisomuastedogtsosgpehnyer/attaenndeegmatmiavsesly charged ounsisn.g Mon, Bhidhaffornasgamreentseoloectisedmwointihthe Coliigally digeoc used 2s 0 isnotleurtniaolnsstwaenrdearmda.dTeriapnldicpaetaeiknjaercetaisownerofetchaelculated lectrofonniscaanldy.calibrat "TFheca2libraa4ntiothn2ceuinrtve)ernwaalssgteanndearradt.edDbaytarfeogrreesssitosnoalnuatliyosnisswuesriencgtohmeppaeraekdaorehareactailoibfrraotmiotnhe curves to evalua the concentrationsofthe F-24521. RESULTS H`a2p4pr9o2x1imaetleultyed4.f9rommintuhteeHsPfoLrCthceonleugamtisveaiorne.soTlhveedsppeoanksowritrheaporrteetednatipounrittiymeofof hen the sample was submited. _ Table1. The pert of a. ntheH-24p9o7m)sEam2p0le21anayed SeptePmebcearn4,2003. 1" TOoogemesd Moesgsied No9%minal 23 oOoomi oooom %964s4 Standascd ecagePeDrecveinattNioonminal [Cotficientof Variation 292661 2% -- Company Senitized. Docs not contain TSCA C31