Document ba7rB3znQz0mXKqYRJqEDJVGg

DDeecceemmbbeerr5,, 22001111 PPrroobbaabbllee LLiinnkk EEvvaalluuaattiioonn ooff PPrreeggnnaannccyy IInndduucceedd HHyyppeerrtteennssiioonn and and Preeclampsia, Preeclampsia `CPCaoonnneccli,luusswiioeonn;c: oOnOcnnuttdhheee tbbhaaassliistshooefrf eeeppiisiddaeepmmriooioblloaogbgilicce aainnnddk oobttehhteewrresseccniieenentxitipffiioccsuddaratetaataaovvPaaiFillaOabbAllee(ttCooE)tthhaeendCC.88 Science Science pPprraeenggennl,aanwncceyy--ciionnnddcuulccueeddde hypertension that there is a hypertension. probable link between exposure to PFOA (C8) and Introduction - C8 Science Panel and the Probable Link reports Introduction - C8 Science Panel and the Probable Link reports I`InnAgFFreeebberrmuueaanrrtyy i22na000055l,,awttshhueeitWWaeebssottutVViirrrgegilinneiiaaaseCCsiiorrccfuuiaitt CcCohoueurmrtitcaaapplppkrroonvvoeewddnaaasccllaCa8ss,ssoaarccttPiioFonnOASS,eefttftlleoemmmeenDntutPont's AWhWaagasdrsehshieeinmnvggeetrtnooatnlninpWWaoraotrsrlk.aksswsffauacitiiliatlybollouoctcaaretteeleddaiisnneWWsooooof dda CcCohoueunmnttyiyc,,alWWkeenssottwVVniirrgagisinniiCaa.8. ,TTohhreePSSFeeOtttAtlei, mmfreoenmntt ADgurPeoemnet'nst. Agreement had several parts. `One part of the eOpnideempiaorltoogif sthtse, SSoeettttclleoemnmedennuttlwwraaesssettahhreechccrrieenaatttiihooenncoooff maaSmScucinieeinnccieen PoParandneeelrl,,0ccoeonvsanilssutaiintgesowofthftiethhtrnrheeegeer there s a epipeprrodoidbebefaamibbnllieeeodliolinnngkkistbtbhseee,ttwStwoeeetecetonninaPPmdeFFuncOOttAAAregeesrxxeeppaeoormscseuhurnreeitn aatthonneddmceaaonanmyynhmhtuhuumamntaiatgnynidvindieisnsoeetradahseseeera..tvoAAaie""avppbarrlloouebbaaastebcbilleewenthiliiennfktikhc""eeiirnvnittthdhheeissnrecsseeei,sttttaitininggs iammsnooddrreaeefilnlipikeakeerdlltyyiincttuhhtlahaanern hnnSouoettmttttalhehnaamttdeaainsmmteozoAsnngegg.reccellamassessnmmt eteommbmbeeerarssn a connection exists between PFOA exposure. that given the available scientific evidence, it a connection exists between PFOA exposure is and a particular human disease. AACnlnoaotsthsheeMrreppmaabrrtet rooffstththeherSSoeuetgttthlleqemumeeesnntttieeosnstntaaabbilrliisesshheaeddndtthhbeelCoCo88d HHteeesaatlilttnhhg.PPrTroohjjeeecsctet,, dwwahhtiiacchhreccopolrllleeecsctteeenddatddpaaottraatiffroronommof wwbChehlaatastwtsetthehMeneeSSPmccFbiiOeeenrAnscceeathnPPrdoaaunhnegeulhlmeeaqvvnuaaelldsuuitaasiotteeenaddsnteato.oiraeEansvnsisawdwneedenrrcbettlhhoeceoodqqmuuteeeesssstttiifinooignnoo.moTffShwcwehihseeeetnthchdeeaertrPaaaarneppreproorerbbeasasbebelnleaetrlalcinnhpkkoteehrxtaxiitoissnthtssaosf bbeeetwnepeunblPiFshOeAd aanswdelhluamsanScdiiseenacseeP. aEnveildernecseeacrochmtehsatfrohmas SnoctieynectebPeaenneplurbelsieshaerdc.h that has been published as well as Science Panel research that has not yet been published. tIinno pCpelerarffsoosrrmMmieinnmggbetthrhiisss,wwoobrurkkt,,ettxhhaeemSSicncieieednnccaleel sPPacaneneneltl fwwiaacssalnnoorteliliemmviiattneetdddttaootcacooinnnsscilidduederirnaagtt,iioonbnuootffnddoaatttaiatrreeelladattiintnogg, oodnanltlyya rhtroeeullaCmattaliiannnsggsettoxoMpPPeomsFFuOObreAAerseed,xaxtbppauoo,stsutueorrxgeeaemaathmmineooernndwggiahwlwloosrrreckklieeeernvrssat,i,nfitacaammalnoloyinnmrggaellppeaeevanoapdpnllteetdoxiiannitcaooottlihhnoeegcrirlucccadoolinmmdgmamu,tanub.inuttTiitiheneseos,t,SlaaicmnniddietenoodcttehhtoeeP,rradnaelta hthhhaauessmdddaerrntaaaweiwlxnnepdooonnesvueeirvvediiedddneaecntneacc,eeutsottehhgdaaetttbhhhyeaatrsshwbebieetPheeannnreeoolleppevtenanlnliyytnfapponuuribbmmlliastsshlheaecdndodnbbcytylouoxostitcihhooeenlrrosgiinsnicvvaeeaslsvtatdiiigaglaataattboo.lrreTss,h,foewwhohStiihccceihhersnmm.ceeeaaPnnsasnttehhlaatt the detailed evidence used by the Panel to inform its conclusions is available to others. oCCfrriirtteeerpriioaartuuessdeeddasttsoooceeivvaaatliluuoaantstee, ttehhveeideeevvniidcdeeennoccfeeaffodorrosaaepp-rrrooebbsaapbbollneeselliinnrkkeliianntccilolunudsdheeiddp,tthhteehessttprreoetnneggnttthhiaaalnnfddorccoonnssiisstteennccyy. oaaasfnsssdroeocppciloiaaarutttsieioiodbnnislsaistttoysoooboccacicascuetuirodrnaaosssn, aaeevxrreiepdsseeuurlnlittcmooeeffnocctfhhsaaainnndccoleeas,,beoaa-rrddaeeetsqoqpruuoyaanccasynyeoimofrafeclclosao.ntnitotnoTroslhlheffoiopor,dbbtdhiisaeassrpeeasosttoeaannnwdtdaiasoolttfthhoheererr pccraaiuumssaeerssy,, aCmmnoeedmaapsspauulrarreueedsooibftfioalaisttsyshsoeobccariiisaasettkiidoonnnonttthhheeaatxtupwwneeeerximeepxxoeaasnmmetisdinneineodrd.la.lboTTowhh-raeeextopooroddysddeassdn.rrimaatiTaioolhseii.ss anaTuhlmmleaavkoarkedleudrreosof~rfahitthnioedeiwcfraiasstkskintiignhneneeoxxppprioomssaeerddy caaisonsscmsorocpeciaaiaasrteteiidodonnitosbbketehtvtewiwteerhieesnnkinieecnxxrtpephaooessseuuudrrneeeexxaappnnooddssuooeruuedt.tcocoroVmmlaoeelwu----eesiixsspf11oo..s00me. d0VV..aa0Tlluu0heeess0.naaubbllaoorvvveaeeleu11ve..i00-deaainrrneecdeieecvvoafiitdiddneeegnncccnreeoeaoofsfed risk wwoinificttthhrheeiiannssccetrraedteaiarsssitseeikcddawleexixptphrpoeoscinsuiucrsrrieeeo.a.nsoW Wefdeetheaaexllpsosooodsdeeusxxraearamm.tiiioVnnseea. ddlu9e99s555%%f%roCccmIoonng0fef.iin0ddeeetronnacct0eee.9iiannattrereearrvvneaaglvlessido((ef99n5p5c%l%eauCoCsIfiI))bdlaaeesscvraaeaalmmuseeeeasdassuruirsreek taking of the taking chance into account statistical precision of chance into account. the odds ratios. 95% CI generate a range of plausible values EExxhhiibbiitt 1 22334433 State of Minnesota v. 3M Co., Court File No. 27-CV-10-28862 IM_MNO2585047 3M MN02586047 22334433..00000011 RReveiewvooffEiEvivdeideenncwcee: PrcPeornegsgninadanenrcceyyd-iinnddbuuecceesddighhnyyippfeiercrttaeennntsseiioloennviaistdeddeeff(inisyeesddtoaalsiscaa>nn1e4el0leevvmaamttiioHonnginnorbbldloioaoosddtopplrirecess5ss0uu0rreemrrmeeaarcc)hhiinntgghallteevvbeeellgssins papcaprifofrteeotneeeeesrcicithdlnlhaeeaemirmnep22ptds00osi~ittaaoh,wwebeiiesseueerddkiksiniiaegaoo.gfngfnnippfoBoirrcsoeseaetgegnnhddntalaywpnwnrchhecyeeely.senn.cvlattAAahthsmeeesppdepsleceie(liesacvfyviafiasaitcctntioiodffoloinncorpmmrii>nne1ogobb4fnfll0oaopponormrddceemyggpp-nnHrriaaeegnnnssdccssouyyuurc-r-rediieendniaddifshsuuytcacaopeeccleiddcccroothh>memyy9npppp0seaaeirnmonrtitneiemeennwddsHisitigobbohnyy)no,t,ullheteccaaaaaptklkrlallboaeegetgddeegeiinnoofsf iapinnreotththereeoinuiutriinninnteeeolyatahrmreeeonucctoroionmmermm.eedoBnndoupptrhrrieenpgggrnnepaaernncecclagyymnccapoonmsmcpiaylpiliacicnanatodtirioodpnnersers.g,tnoaaanndnddectbybecl-loitonoodadduncppderrmeedsassshnuuyarrpgeeeeraatnentddnhesppsiorreonotctewoainnnidthiiitnoiuotthtnhseep.rurortiieninen TTabihrheteehssroeeuPcctrioonenneeddclyilitiaimoomnnopsssniiaataorr.ereeiaadnsspsdsaouorcrctiiiinaacgultelepaddrr.ewwgicitnahhanrnrceecaddyuuuisccneeeoddsrdeffereltoralultosgrrdhooeewatewlthclhtaaapnnnrdddoaabmnnleaicmnnrscaergfeaerassttheeheddesermriiosscktkohooneffdrppitarrioeennttdeser.trmhme fboirltuhs. thParteceacnlabmopaslilae,viinatpeadrtiocnuylarb,ycadenicvearuisneg he fous serious health problems for the mother and the fetus that can be alleviated only by delivering the fetus. 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TTioothaasscsseeersstisscttahhteeesaa,cccwcuuerraaeccxyyamoofifnttheheed iitnnhffoeorrpmmaatatttiieoornnnowweerooebpbtotaaritinneeedpddrddeigrienacatcnlycfryrooimmndttuhhceeedmmohotythhpeeerrrssenaasnniddorfnrooammndtthhee appbsrrireetsheeoccccllaeiamramtiptpfiscisiaioaaftneoiisrsnn,krrweenlleaoatwteionoxnnaimttsookinkkfennadcootwwothrnnse:ppprreaerditditseickctrtwnoorarsoss.f. mreWWaproeokrewwtdeeeldrryeepirrreneecgaarnsseassaunusrrceeeyddd-iinntoodsfursesceteeewdpwreheelygllpan-eeasnrsttcteaainbbesllsiissorhhnleeaaddtnvde to associations for known risk factors: risk was markedly Snounb-ssemqoukeenrts.pregnancies and risk was reduced among subsequent pregnancies and risk was reduced among women who increased in women who were Smokers relalve fo first pregnancies relative were smokers relative to to non-smokers. ThTyhhpeeereetveivndseiinocnedcttoooeemveenavslaculufarateoteem ttfhhoeeurppsrrtooubbdaaibbellsee llirnnekkebboeefttwwweeheenniPPacFFrhOOeAASceeixxappnoocsseuurrPeeanaaennlddsppturrdeeigegsnn:aanncc1)yy--ZinnIdPduuCccoeeddde- b2bh0aay1sps0eee)drdtePP2n)FFsOEiOosAAntiecemxoxapmptooeessdsuusrrfreeeormaaunnmddfoPuppFrrreeOsggtAunndaaaninenccsdyy,p--rtiihnenrdgdeunuecaceenoddcf ywhh.hyypipdceehurrtctaeeernnedssiiSohocnynipeffernrooctmmeenPbbsiiairttnohhnelccbeseartrustfidefiidicceaasott:eness1bi)((rNNZtohoIlPlaannCoteadtlea.-l., ac2clee0rr1tt20iff0)iic;1ca12atb)ee,EcreusotncirmoderdadrstserdffeoovrrsieeOOrwnuh)mioo3)aaPnnEFddsOtW WAiemesaasntttdeVVdipirrsrggeeiingrninuaaamnccPoocyFuu-nnOinltAideesusacnwwediidthhphrleyeelpegvenveraatlnteeecnddys-iPPoinFFndOObuAAacseeeedxxdpphoyoospnseuurbrrteierathn((SsSiaaovniitzz eett b4ab)laa.,ssPee2rdd0o1sooplnnbe,cbbiiiurtvtnhhedcecseetrrurrttdeiifyviccieoaafwtteeP)ss;F3ofOo)rArECCas88tnimdHHpeaerataeleldtgthhnsaPPenrrrcouojymjeeccitPtnFdppauOarcrtAteiicdcaiipnphadaynnptptessrret((gSeSnnaasavivnitoicznyee-btitnaaadsl.lue.,dc22e00od11nh1lbbbyi,,prteuuhrnntceddoenerrsfriirorceenavvtiieeewws)):; 4piinnr) obbPibirrratotbhhslsspesesiiicnnntcikcveeebttehshtteeuwdCeCye88noHHfPeePFaaFOltOlhAAPPerarxoonpjjdoeecsctputrr((ememgaanannanuundssccprcyrir-iieppnettdcnuiincapepmrdpreespphiaaaryarptaceitoriootmnen)en.)s.siTTofhnhoeembeeatvvswiiedoddeeSnnocccnieeebnttiorcoteheevvPcaaaellnruuteaaifltitceeattthehese pSspatrucrotdbiiiaeceibsp;lea1n1)tl)isnMMke(eSabtaesestiuuwnroreeefeddnssPeeal.rrF2uuO0mm0A9PP)e:FFxOOp2)oAAsEauasnrnteddmsaasnleldelfd-rpreerspepooeorrcruttleamedmdPpppFsrrOeieaeeAcccllaoaanmmmdpespsssaiifiaaroaaemmpmotoorwninogedSCCcE8pierHHneeeceaecalllttPahhmapPPnsreroioljajeecctt amongCB Healih Project particpanis (Savz participants (Stein et al., 2009); 2) Estimated among C8 Health Project participants (Savitz et a.serum et al., 20112, PFOA 201 la, i press) and self-reported in press). preeclampsia 2 M_NNo25e5048 3M MN02586048 22334433..00000022 Eoidemiologic Studies on Mid-Ohio Valley Populations Epidemiolo,qic Studies on Mid-Ohio Valley Populations W rWeeleatcciooonnnsssihiddieeprrbeeeddtffwooeuuerrnsstwtuuaddtiieeersssooeffrvppirrceeeggnnaaarnencacyya--niinndddupucrceeedgdnhhayynppceyer-rttieennnsdsiuioocnen.d. hTTyhpheerfftiirerssnttsssittouunddyyfoerexxOaahmmiioinnbeeiddrttthhshee (cr(neen=lr=at11ti,i,o5c5na44ts88eh))ipiiinnnbfaaoerstswmmmaaelaleilllonnppwaawraratttesoorffuttsshheeeerdvaaictfffoefeedcacettreteededarrrmaeeinggndiieoonpnPrffeFrrgoOonmAman22ec0x0yp00-o33ins--d2u2u0r0ce00e55bdy((NNhZooyIlplPaaennCrteoeeltdnasael.il.oo,nf22r00fo1e10sr0)i.O)d.ehniBBociirerbtthihartnhds to tciidhdeeeernnttiLftiiiicftytyaetpperrHeeionggcfnnkoaairnmnnccgayyt-W-ioiiannntddeuwurccaeeAsddssuhhosycyepipdeaerttroitteoednnnesssitieeoorrnnmvi((icnnne==ea11Pr55eF77a)O.).tAoTTedhhexiifspsionsssettuuuedrdleyyevbuuayssteeZedddIPZZeIxICPPpooCdCseoouddroeeefssraenoosvdvitederherllneaacppfeippniiandninggndgwwsit.iotthh wtwphereerergeeLnitllaitimlnemciitytHee-dodicnbbkdyyiunttcghheeeW dqqhauuyateaplireliltrAyytseoosnffoseeicxxoiappntooioassnnuudrrseeZeIaravPssisscCiiegognndammreeesenatnt.ttho.atdTTwehhefeeirnrreeee wweexalaecssvluannstooeivdaaeslseyssxoopoccroiiasaptautirirotoeninaalbblneeydftswutewhereeevenenfidndbiyngs pregnancy-induced hypertension ALsisolciHaotcokni.ng Water Association Little Hocking Water Association as compared to and ZIP Codes as compared to ZIPthat ZIP codes nit served were exclusively codes not served by Litle Hocking or partially served by Little Hocking Wbayter Water Association. "TiTnhhdeeuscseeedccoohnnyddpessrtttuueddnyysioooffnppwrreeaggsnnaaindneccnyty-i-fiinineddduufccreeoddmhhbyyippretehrrttreeenncssoiiroodnns wwfaraossmaa1SS9c9ci0iee-nn2cc0ee06PPaafnonerelflissvtteuudcdyoy.u.ntPPirreeesggninnaanOnccyoy-- taainhnndeddutcWWieemedsesthotfyVVpipirrerggreiitngenininaaasni((oScSnyaavvwwiiteazzrsoeetitdbaaealln.,s,tief22ide0011don1lfbbro,t,hmuuennabddimeertrorhurrnreeetvvciieooefwrwd)P)s.FfTTOrohhAmeerhhe1iil9sset9tooa0rrsi-iec2cdaa0ll0fss5reeofrrmouurmtmhfievPPeDFFucOOPoAAounneettssiettpisimamniaanttt,eeOsshiaaott twwcheiirenntdditifmippcaaeattttteoeefrr(nnpSsshr.,eingrrinivevaetenralcff.llyoo2www0,,1eg1greraroo,buuannbs)dd.ewwdaaTtotheenerrrtffhelloeowwwaa,,msaanonndduonttathhseoesforrcPeeissFaiiOtddieeAnontntirieaballeletaaawddsededredreenfssressosmlltiisisttmteheadedteooDdnnusPtthehoerenutbbmiiprttPlhahFntO, A ahcaennedrdtnifppicrrweaeegtgennraa(eSnnscthcryiyni--ciitnenedtdduautclc.h,eeedd2a0nhh1ayyllppayees,rrittbsee)n.ntsosTiiotohhnneer((6enn8==w22%2a24so4)f.)n.porHHaeoogswwnseaoevncveciearirt,e,iowswnewebhooeebtbrswseeeereervvxneepddoessaautirmssemmawataelaldlsaassesesssrotoucicmimiaaattPtiioeFodnnOA IbwbaahPsseeenCddowodoennereeaexxvsaeatcrrcitactgtsseertsdre.eetehtteUaasaddinddnragreelyesssxssriasacratttothhsettehrrreetteh6htaa6ann%ddiinnorccefllsupusdrdeiipngnrggnoatvthnihodocsesieseesawwwiimtthhohereereexxppaeoocxsscpuuuorrrseeauleereesstetwiismmtaaaistmteeaeddtsetbibmoaafsasseeteedddroounnm cZPPaIFFPtOeOgCAAooreedyxx,eppvaooisvsteuuhrrraaeedgjfferurosso.mtmeUdddrsroiiinnndkgkdiinsneggxraawwtacaittoetessr.trfr.eoreTTtthhhiaiessd3dss%mmr,eaasl4llsl ,aapssarsosnovocdicidai5eat7stiiooqanuniwmnwatoiaslrseesilaimmocifcitt1ueerd1dattt(eoo8tte5hhs%eetimhhCIiiaggt=hheee0sos7ttf-ees1exx6ppr)uoo,mssuu1r.ree0 (@5% CI = 0.6-16), and category, with adjusted (95% CI = 0.6-1.6), and 1.3 (95% CI = odds ratios for 1.3 (95% CI = 0.82.1), compared to the 1 and the 3r~, 4th, and 5th quintiles of 1.1 0.8-2.1), compared to the Ist and 2 quintiles combine (95% CI = 0.7-1.6), 1.0 2nd quintiles combined. "TSTchhieeettnhhciierrddPssattnuueddlyysootffuppdyrreeiggnnhkaaenndccyyb--iiintnhdduurcceeecddorhhdysyppfeerrrottemenn1ss9iio8on0n-ii2ss0aa05ccoofmmrpopamarn1ii3oonncottuoonttthhieeessseeinccooOnhndidossttauundddyy..WeTTshhtiiss VVSrieicrvrigigeeiinnwn)ciia.aettPooTahppinrrseeelsggtsnnutaaudnndyccyiiaeellisssnokrreeeedppxooabrrmttireietdhnderbbdeyycpwwororoedmmgsenefanrnonmicinnytt-1hhn9eed9uCC0c-882e0dHH0eeh5aaylplftrtehormtPPrerono1js3jeeicccottno(u((SSnnaat=vivei2istt5zz0in)eettOaaaslh.l.ir,oe22pa00on11rd11t5ebW,d, eouusnnntddteeherr. bhrbeiiirrsvttthiheorwccyee)r.rrttefiTficicchoaairtstdee.es.dtuPPidnFFytOOahAAelsoCeex8xeppxoHoasesmuaurlirnete,he, dPhhroopowwrjeeeevgcvetnerarr,,natcwwhyaea-rsisntdeehussatctniimejmduaastthteeyddtpheuuesrstpiiennonggistttihohienen-cc(tnooi=mmm2ppr5rre0eeh)shieaednsnesnsritieivvpaeelorrraetedessddiirddeoeennsntstitiahalel lhhliiisisssttetteooddrryyoonngreettcnhhoeeerrdabbetiirdtethhdinccIeettrhrtetefifiisCccuaa8tptepe.Ho. reAAtannlaftaholrlyyPsasirnissojaeoosfcfsteeocsrsaittitaimhtmeiaaorttenethddwaissnteehjrruupusmrmtetghPPreFFaOnOpcoAAyin-bbtia-anissndee-utddicmeoodenn hrtteyhhpseeidrfftueulelnllntsriraeielossniiadd.deendntrAtieisaasllsan achaahilstleeitrorbnnrrayaatttigiivvoeenentemmoreaetttthhheeooddd2lo0itof0tlfee5es-sts2uit0ipmm0ap6atotimrintneggfaossrsueearrrnueumadmslPsPeovFFecOlOisaAA.tiolleTnohvviweeslissthaaalpttttrtehehmegeatniitiavmmneeecoeyosf-tifnippdmrraueetcggiennoadannnchmcyyey,pt,ehwwroteeednuusssstioeerneddn. gtAhsenaend tttchhhaeeelib3aarssasstoioc4oci7nai,attitaoioonntndh,,e5bb2uut0qt 0utthi5hnee-t2rreie0e0wws6aawssmeaaernnaes1iiu.rer0reeg(gud9ul5llaea%rvr eddClosoIs.s=eeT--0rrh.eei7ss-sp1pa.ool4tnn)es.srene1a.ppt6aiavt(ttetee9rer6nns.%.timCTTIahh=teeio1aan.dd1jm.juu2ess.1ttteh)e,doddaoonddsdtddrsse1n2rrgaattt(hiio8oess5nf%feoodrr CI=08-117), compared to the 1" and 2 quintiles combined. the 3r~, 4th, and 5th quintiles were 1.0 (95% CI = 0.7-1.4), 1.5 (95% CI = 0.8-1.7), compared to the 1,t and 2nd quintiles combined. CI = 1.1-2.1), and 1.2 (95% "tTThhhaeet offocouucrruttrhhressdttuudfdryyooomff2pp0rr0ea5gg-nn2aa0nn1c0cy,y--iianfndtdueurcceeenddrhohlyylppmeeerrnttetennissniiotohnneaaGdd8ddrrHeeessassleetddh Ppprrroeejggecnntaa.nncciTieehssisttooCoCCmllaamssussniMMteeymmbbeerrss S`tChCeoaorhhtuooormrcttcPffuooFrlllrOoleowAdw--mufurepopamsssttuu2urd0deyy0d5ee-ssi2ntt0iim21m00aa0,tte5ead-df2tses0eer0rre8uunmfmroorPPlltmFFhOeeOnAAetslliteneivvmtehaeletsleaCadt8dtthehHeceeitatnimlmetheeaPfootrffeorppjerrrceeetggm. nnoTvaaannhlccisyyoCfbboyyPmFccoomOrrArrueenccfitttryiinonmgg smrmeeuupnrunoircmictiieppPdaalFlbOwwyaAapttaeemrrrteissacuuispppupaprlneliitedesssoinf((mm2taha0nen0uu5Css-co2rcm0irmip0put6tniifinnotrppyrrteheCpepoaarhearoastrittitiomonSn)at.)t.ueddTTyhhditiessocOsslihttnuuieddoyyaaflltnienidnrkkeWreeddemsbbotiirvttVhahislsrog((ifnnn==Pi1a1F,,Ob55i86At44h)f)rom crcSeeeerprrttoiuffriimtccePaadFtteebOryrAeepccaooarrrntdddicssippffrraroenomgtmsna22on00f0c0t5yh5--e-2i20n0C1d1o0u0.mc.emdTTuhhhneeyirptryeeerCwwtaoaenhsssoeeirvtoviniSdd(teeunnnd=ccy1ee0to6oof)fOaabhnnaiosaaessadssnoodoccinW iaatttehiioesonntcVobbnieertgttwiiwnneeiuaeeonnubseeirstsehttxiimpmoaasttueerdde serum PFOA and pregnancy-induced hypertension (n=106) based on the continuous exposure 3 3M_MN02585040 3M MN02586049 22334433..00000033 ipinnddeiiccaarttoorcr.. eoTTnhhfeeetxaapdidojjsuueussrttseee.dd oodTddhdsse rraaadttjiiouoswwtaeadss o11d..2d25s5 ((r9a95t5i%o%sfCCo1I ==h00e,.99277%--,11..36622,))4ccoo,mmappnaardrii5nngg qttuhhieent77i55lte"hswttoeortthehee222255t"h (ap(9s8e55rc%c%oeCmnCIptIiale==rse11.do0.:0f5.t-e15)o,x.t1ph)oe,s22u1..r"89eq.((u9iT5n6h%teeC.5CaIld=T%j=uhs1et.es13de-6.eo.l4d3e)d,vs2.a2tr6.6ea6(dti(o6.9os55d4%%dfoCs)rCIrthIa,=te=io21s1n..d22i,.n-65d3.ir.9~9c),a),,4tateahn,anddamna22dr.88k5et((hd9ql95yu%5inCh%tiCi1glIehs==e1rw21r6.ei2s.r-ek69.)24,.)2, as compared to the 1st quintile. These elevated odds ratios indicate a qaubiontvieletsheof1expquoisnutriel.e of exposure, although there is no gradient in isk above the l't quintile of exposure, although there is no gradient in risk across the 2 through markedly higher risk across the 2nd through 55th quintiles of exposure. "TpTrhheeeefcfiiirsrastmsspttsuuiddayyaoomffoppnrregeeeCcci8laammHpepassliiataheePxxraaommjieincnteeddpamrmteeiacasispuuarrneetdds fssreeorrmuum2m0PP00FF-OO2AA00aa6nndd(Sssteeeillfnf-ereetppoaor.rtt2ee0dd09). The ChCpe8r8eaetHHcheelaaaitmlnthhtpesrPPivrariooejajewemccattonwwndagabssCloaa8ossdHuuecrrovavleelteyhyctooPiffrooCCnljleatacosstssmpeMMaaerestmimcubirbpeeearrnsPstsFccOfoornAnoddmuluecc2vite0eel0dds0iai-n2n022d000c600i55n(--Si22ct0e0a0i0n6h6eettahtlhaatahtl.,iimnn2acc0rlluk0ued9dre)es.dd. TaahTehe a0ahnneaaawllloytyhssmiieissnntwweaawrvsshieorrweeshstaatrrndiicdctIteevbddelodttoooidnlivvcteeohellbbeisicrrtatthihomssne((ntwno=a=1t1m.e,5e5r88ai59ss))utrttehihaacPtt rFooOoccccmAuurrlperrreeveddeglsiinnnaattnhnhcedeyffctiivlhvieneriocyyuaeeglaahrhrssseeapprlrrtihuioomrrmttPoaoFreekOnenrArrosol.lllmmTeehnnett tmamopeepawlasiosucmurarebeelmnmeenwe(t0nh.tot.hheTTahhtdiimssleirvreeeossdfttrrpiiincrctettiigohonnenanhshceaeylml.ppeeeddMweeeanantesssuruurrrdeeeisdththraisactett rttfhrhuoeemm22P00pF00rOe55g--A22n0w0a00an66scyssweteehrraruukomlmuygmmhaeenasadsesruruurermeegmmuPeleFnanOtrtyAwwaass aaapessprsspcooleicccnitiaaaibttleleeedd(twowiimttthhheepptrriemedoeeefccileloaaxfmampppporsnsesiiguaan)r(a(envn==(c11oy55d.6d6)s.)Mr. aeTTathhsoeeurrr=eeed1ww3sa,aessr9uaa6mnn%eePlCleFlevvOa=aAtt0ee.wdd9a1rr.siis9sk)wk.ffeooarrTkwwhlyoiosmameeneldnneviraaartbebeoogdvvueelrairtsthlkhyeeab55o00vt"e tt=phh'eee1r.cmm0ee:end2dti3iliea)annm(mowwreaaedssiatddnhrraii)vnveoenfannebbxiyypnoaacsnnrueiiarnensccer(rdeoeadarsidssesekddrianrritistisokhke=iin715tth37he.e, 95950050"7%t".-p77eC5r5Ic~"e=nppte0eir.rl9cce-ee1n(n.to9tiidl)eed. s((Toorhddaiddsisser=rleaatvt1iiao2ot,e==d9115.r.55i%,s,k99GaI55b%%=ov0CCe.II7- 2.1) o abothve 5e0" percent (odds rato = 0.9, 95% CI = 0.51.5). = 1.0-2.3) more than an increased risk in the 75t~-90~h percentile (odds 2.1) or above the 90t" percentile (odds ratio = 0.9, 95% CI = 0.5-1.8). ratio = 1.2, 95% CI = 0.7- TTpahhreetissceiepccaoonnntdsd fssrttuoudmdyy1oo9ff90ppr-ree2ee0cc0ll5aamm(pSpsasiviaaizeexxetaammal.iinnee2dd01ee1ssatt.iimmianattpeerddessss)ea.rruumTmhPPeFFSOOcAiAeanacmmeoonPnaggneCCl88 gHHeeenaaelrlttahhtPePrdrootjjeheectt shpHtiiaussrdtttyoio.crriicipcaaTalhnieetssssttfsiirmtomumaadttyee1ssi9noo9cff0lssu-2dee0errud0um5am (lPPSaFFargOvOeiAAtrznaaeummtmoaoblnn.e,ggr2GC0olf1laa1pssarss,egMMinneeapmmnrbcebeiseersrs)ss.(((vTSS=hhh1iei0nn.S1eect8ti5eaal).nl.,cae22n00dP11gal1rnaaee.,altb)ge)reuuntsseieermddaetieisnndpthahthnsise ttsbhthauaasdnney'dt.hhoeeTnhssitttsuhudedsyytaubbmdaaoyssuieennddtcluooodnfnePmmdeFeaaOasAsluaurrrrgeeeedldressaneseuerrmudumbfmerrPPoFmoFOfOtAphA.er.eDgTTunhhPaeeonnchhtiieissspttool(rraniic,c=aa1llw0ssi,e1enr8rdu9ump)mataPPtneFFdrOOngsAAr,eeeaissvtetetirmrmfataillmtoeewess.swwpeearrnee g2gb0rra1oos1uueannd,ddwowban)a.ttteehrTrehfflaleoomwwr,o,esuaaunnnlttddsottffhhoPersFrerOeelssfAiidrdereeenpntloetiiraaatlsl eehhddiisspfttrroooerrmyeycooitffhaCeCmpB8DsiHHuaePeaao(llnnith=th7pPP3lra0roon)jjtee,sccwtht iopnpadawrreitpiaccdaiitpptmeaaornnntdtssse,s((rStSivhhaeiisnrnsfeoelotctwiaaa,l.t.,ion wwc2io0ittn1hhtliaeenss,uttoibimu)m.saattTeeexhddpeossrseeeurrsuruumemltsiPPnfdFFoiOOrcasAAteoaalrft-twrttehahpeesottr1itmie.m1dee3 poo(frf8epp5err%ceelggaCnnmIaanp=ncscy1iya...0(0nTT-=1hh.7ee238aa0)dd).jjusuchssottomeewpddaeroddiddandsgsmtrrohaadettieoo7sffto5oarrt"sttohsheoetcheiat2io5n pIcpeoer=nrccteienn1ntu.ito0illue1e5sss)eoo,fxf pee1xox1ppsouo(srsueurreien.8C.dIicTT=ahh5te0eo8raa-wdd1%jaj4uus)ss.tt1ee.d1da3nooddd(9dd15.2ss%rra8Cati5oIss%=ffo1oCrr.10tt0=hh-ee110.332-r1%~8),,),44c~c.,omaaonnpddar55min{"gqqputuhitinenottiati7lle5he~ssehrw1wtoeertraeheene11d2.2d252t~((9855%% qqqCuuuIiiinnn=tttiii1llle.ee0sss-1cocf.oo5mme)b,xbip1inon.e1sedud.r(9.e5.TT%hhseeCssIeea=noo0dda.ddl9ess-r1irn.a4aot)li,oisvsaendddmooe1nni.oo2hlto(ssd9hh5ooo%fwweCsaaiI ggm=raraal1ddi.i0inee-gnn1tt.s6iien)n,rrruciisomskkmPaapFccarrOrooeAssdsslttheohveetihs33e~a1tsthtthrharoenoudutggh2hm~55tohf qpMpreureetingghtnniolaaednnsccsyoyt,f,reewwnxeegptouuhssseueenrddeed.ccaatAfhlisebbrraaaasnttsiiooaocnnlitaetttoroinottahnht,eeive22wi00mt00h55e-a-th22do0j0ud00s66toefmmdeeesaoatsdismduusrareetaiddnlglloeessvveeelarlssuc..mroTTsPhhsiFisstOhaaeAlet3elmer,vnaea4tltsvi,veeaatneetsdhstetii7mmtiamatteiioononf qQcmuuoieinmntthpitiolaleedrsseosdotfrfte11n..gi22hth((e9e951n5"%e%danCCtidhI e==2"a11s,.q00s--ou11c.i5i5a)t),t,ios11n..,3c3ow((m9i8bt5hi5%n%aeddCC.jiuI s==tTe11hd..e11o-1a1d.s.d7s7)so).,criaaaatnntioddiso11na..44cbre((ot99sw5s6e%%ethnCCeieI=3s=rtdi,11m4..a1{1"t-1,1e1a.d)7n,)sd,e5rtu" m cPpPorFFemOOgpAnAaarnaaecnndiddetsopprr(teeh2ee0ecc0ll01aa-'m~2m0app0nss5dii)aa,2wwndwaaiqsstuhaainllasstdiooljeustsstrrtceeeonndmggottbhhdineesenndeca.ddlTwwohhsheeennnatswwhseeeocrruieeapsspttiteorriirncctatebeudeditntwththeieeeesaannnraeaalslnyytgsismiiisnsagtttoeordmomomsorerere1u.rmr3eetccoeenntt ispregnancies (2000-2005), with adjusted odds ratios in the upper quintiles ranging from 1.3 to 1.5. EEpidiemidolo,eqicSmStutuddiiieessooonnOlOththeoerr PPgooppuulilaattiicoonnss TTprooeooguunrar nkkcnnyoo-wwillneeddduggceee,,dtthhhyeeprreeertaaerrneesinnooon.aotthheer eeppiiddeemmiioollooggiicc ssttuuddiieess tthhaatt aaddddrreessss PPFFOOAA aanndd aannyy ttyyppee ooff pregnancy-induced hypertension. 4 22334433..00000044 IM_MN02585050 3M MN02586050 MMecehancistihcaannadd TTnooxxciiocololosgqiicctEEvviiiddeenncccee TtThhheeepttoootxexinictcoioallologgoyyreliPtreaFratOtuuArree(aeenxxdaaommtiihnneiinrnggpeeerfflffeueccotrtssinooaffthheiidgghchoddmoopssoeeussndiinnsrr)oodtdoeennhttammvoeoddaedelvlsserclsleeeaaerrlfyyfeddcootsccuuommneennttss fdtdheeetevavelepldloooetppeammntetheniatn(l,tW,foosslrppfePeceiFctfiOfaiiccA,aall(2llay0yn0rr7dee.dodutSuhcuceenedr peffteeettraaafll,luggo2rrr0oion1wwa1tt)thhe,d((dWWceoololamlffypeeetotduaaldn.l.e,dvs22e)00l00too77p;;mheYaYnavathehaiilaaadmoevittelaarelsl.s.e,t2o2en00fe1f1es00c))(t,,sWiiononnccrereteaaass.eedd 2pf2e00ut0a0d7l7i))d,h,eeaaadnnthddb(yiinWncLcorareluefaeaesstteeaaddll.,iri(ss22kk000oo07ff4;nn,eSeo2uon0hna0ate7taat)llasddl.ue,eama2tt0mhh1a1((rW)Wi,oozdalleef leeatrtyaaaetl,lhd.,erd22e00s0vu07eb7:sl;otYpYaamnahtheiiinaaataebetlt ama.l.oio,le22s00te1od10sn0)ee.)a.syrR(RcWehevvoitilefhewrewotssuagl.h, chtphlueeebarlmmi,siihwcde-i-2d2h00b00ay00tessLraaauhnneddealtfftianihldn.,dett(hf2hia0cati0ttt4hsh,ee(2iee0nvvc0ili7dud)edeinsnncucgeemmffomoorrrataraailznnleyaa)dadvvlrieeakrretsshlyeeerteeosffffubeebeccstttooapnnnrtffioaeedtltaaublclotaadannytddpoepofasorstsetntsnaeiatataarplclahgrgtrrtohoowrfowttuhhhgeiihss: clear, with later health deficits (including mortality) likely to be a product, at least in part, of the rnetdhueceodffgsrporwitnhgo. fMeoxsptossetuddimeesrfisnd.no effect of PFOA on structural maformations (bith defects) reduced growth. Most studies find no effect of PFOA on structural malformations (birth defects) in the offspring of exposed mothers. `AsAsessssmeenstoosfEEmvvieiddeennncctee IIinnndoouuucrreoodppihinnyiipooenn,r,tttehhneesieeovvniiddiesennscucfeefiffcooirrenaatnntaoasscssooonccciialatutiidooenntbbhaeetttwwPeeFeeOnnAPPhFFaOOsAAaeepxxrppooobssauubrrleee aalnnnddk {pp0rreethggirnsaadnniccsyye--ase caianlmmdeoauorncneggedvccilhldaayesspnssecemmrteeeomnfmbsiebinorecnsrrs.ei.sassWWiuhnhgfifililcreeiiesffkneewtwwitoloohffcittohnhnececrliieunnadddsieiivvniitdghduuaeaatxllpPmmoFeseOauaAsrsueuhrraaeecsssroaoosffpsaarostsshbsoeaocbcuiilalaettiirloionannnkgaateorreeothfssitlsProoFdnniOggsAeooarrsssehhooww `cepelrxexoppaboorassubeurlvreeei,d,ienttnhkh.cee1erre)eoAaafsrrisneeocsscreeievaavetesriiranaolgnl srrreweisaaekssroowennitsshowbwishnhecyyrrevwwaeeesdiiniinmngteeserrepxpvrpreeoretasitluhereaenppaaaalcttyrttseoeersnrss ooothffferrdeiefusfsuellurltressanntaagssseesstuousppfpopPoforFrtOtiinAngg a a pppinrrrdoeeibggcannaabatonlnerccsiileieansskn:daamm1h)oeoAannisggtshowwocoouimamtteceioonnnmseiinnsw,ttheheeereaCCcoBh8bswHHeeiearhavllettshhdpePPinrcrooijsjeceecvcts.ett.rraeTTlnhhageetnsshaseelyasaanenndasallmyoysasfeetdssiifofuuenssrseee.nddtddsWiiefhfftfeisrrleeoennftnt deevxxippdooussuaurlerle:y ottifnhhfedeiicnooadbbtissoneergrsrsvvaeecnddoduaalhssdsesobaocelctihiaaetxtoiipouolntnacssionccmeoodeuublsldyd, ehhaaaascvveheeriwaaelsiltttheoerfmnsapahtetyiivcvpeieofitceehxxsepptslrliaeaznnnaegatdttihioobsinnassas,,nesdit.iilsism2uu)intnaTiltikhkioeeenllyyso.dtthdhWasathtrtiahhlteeifoifunsudlwlievppiraadettutteaerllnry osS(bitfrorfeitennhndggbitntehhgfeeosnnreeceddoauffnoloddrr tbtahhfeeeteerppxrrpCeel5aggninnHaaenendccaiibeleyssPattrhhosaajettercwwieteesrerneeovfocchllloiyosmspeeeonsstttht)eninswilthziimeemdnee btetooixapttshoheesesu.mmreee2a)aassTsuuhsrreieegddondssmdeeesrrnuurtmamstioPPlsiFFkOeOwlAyAeroevvaabllueueess most (both most accurate. before and accurate. after C8 Health Project enrollment) when exposure assignment is likely to be 5 22334433..00000055 M_MNo2585051 3M MN02586051 RReeffeerreenncceess LmLoaanuuitCCo,,rAAinnngiittaoonleldKKt.,oxHHiocoodleodsgCiCc,ea,LlLsafaiiindDDi,n,gPPs.flahaTloehxsli-cHeoulstcS-ehiHen2u0sl0AA7,c,.S9hSe9ee(e2ndd)s:JJ3..66PP-ee9r4rfflluuoorrooaallkkyyll aacciiddss:: aa rreevviieewwooff monitoring and toxicological findings. Toxicol Sci 2007;99(2):366-94. GLLeaaruuivCCa,i, vBBeusut.teennhThoooxffitfcJJoI.l, ARRpoopggleerPrsshaJJrMMm..acoTTlhhee20dd0ee4vv;ee1llo9o8ppmm2e3en1nt-taa4l1l ttoxicoityooxffppeercrifuluotororoaalyklkyyl aacciiddss aanndd tthheeiirr derivatives. Toxicol Appl Pharmacol 2004;198:231-41. cNNooomllpaalnnicLLaAAt,i, oNNnosol,laamnnaJtJMMe,r,naSSlhhaorfifeesrkr fFFaSSc,,toRRrosoddawwnadayythNNeVVi.,reEElmmatmmieotenttsthEEiApA.w.itCChoonnpgegernefinltiutaaolrloaaonncootmamanlaoiiliecessa,,cilladabb(ooPrr/FiddOeeAlli)vv-eerryy contaminatedpublic inkingwater. complications, maternal risk factors contaminated public drinking water. Reproductive Toxicology2010.28(2): 148-65. and their relationship with perfluorooctanoic acid Reproductive Toxicology 2010;29(2): 146-55. (PFOA)- SaSacavivdiitzezxDDpAoA,s,uSSrtteeeiiannnCCdRRp,rBeBagrantrateenlllcSySMMo,u,EtElcslsottmooennBiB.n,aGGhooinnghgglyJJ,,eSSxhphioinnseHH-d-MMc,o, WmWemluelnlleientniyiuu.ssGEGpAAi..dePPmeierorffliluougocyrroo2oo0cct1taa1nnacoii(ccin press) acid exposure press) and pregnancy outcome in a highly exposed community. Epidemiology 201 la (in SSRaoavlvaiittzziDoDnAsA,h,iSSpttoeefiinnpeCCrRiRu, oEErllossottocotnnaBnB,a,iWWceelalclleiednnieuuxsspGGoAsA,u,rBBeaar{r0tteeplllreSSMgM,n,anSSchhiyinnoHHu-t-MMc,o,VmVieeieibriraaasVVeMdM,,onFFllbeeitctthhcehrreTecrT.o.rds in the Mid-Ohio Valley. Environmental Health Perspectives 20115 (submited) Relationship of perfluorooctanoic acid exposure to pregnancy outcome based the Mid-Ohio Valley. Environmental Health Perspectives 201 lb (submitted). on birth records in SSFhahitinne HaHMnM,d,VTVireiaeinirrsaapoVVrMMt,,MoRRydyaeanlniPnPBgB,f, rDDeePettwrwfillieureoRrRr,o,oSScatanannddoeeirrcss8A,Bci, dSSttEeemeientnliaiendadnfKrdK.o,BmBartathreetelWlllaSSsMMh..iEnEngnvoviinrrooWnnommrekensnt.taall FFaactieliatyndin TWreasntspVoirrgtinMiao.deElninvgirfoonr SPceirlT:leucohronoolcta20n1o1ica,Acid Emitted from the Washington Works Facility in West Virginia. Environ Sci Technol 201 la. SShhiinn HHMM,, predicted VvVieieeriisrruaasVVMoM,b,s eRRryyvaaennd PPsBBe,r, uSSmtteepeeennrllfaalnnuddorKKo,,acBBatarartnteeilllcl SSaMcM.i.d RRceoetntrcrooessnptperecactttiiivvoeenseexfxopproopssauurrrteeiceeissptatiinmmtasattiiiononnt haaenndd ChCp8ir8epHdHedicaetxlaetldthdhoviPPerrr0oosjrujeqecs/ct1,to.0b.EEs1nne2vvr8ivi9rreo/odnenhmmspeeenr1ntu1tama0ll37pHH2eee5ara,lflltuthho2r0PPo1eeo1rrc5sst.ppaeenccoitiiicvveeassc,,ideeppcuuobbncentrations for participants in the http://dx.doi.orq/10.1289/ehp. 1103729, 2011 b. sSStuteleifinnonCCaRtR,e, aSSnaavdviitptzzreDDgAAn,,anDDcooyuuogugatnacMonMm..e.SSeeArrmuuemmrillecevavenelssJooouffrppnaeelrrfllourfooEroopcoitdceatamnnioooiliccogaaycciid2d0aa09nn,dd17pp0ee(rr7ff)lul:oorr6oo3oo7cc-tt4aa6nn.ee sulfonate and pregnancy outcome. American Journal of Epidemiology 2009; 170(7): 637-46. SfSauumhhilCCyHHh,,orCCmhhooonNNeKK,a,nLLdeefeeetCCaKlK.g,ereottwaat.lh.. rPPeeterarfrfllduauotoriroooonoccitntaanmniocaiecc.aaccMiidodl--iinCndedululcceeEdnddoiincnhrfiiibnbiotilioo.nn2oo0ff1pp1llaaAccpeenrntt3aa0ll:pp3rr3oo7ll(aa1cct-tiinn.- 27-1. family hormone 2):7-15. and fetal growth retardation in mice. Mol Cell Endocrinol. 2011 Apr 30;337(1- YYeaxahphioiaasuODr,,eEEtloI--NpNraaessgssneearrnMMtAAm,,icAAebbeeoddneelrI--eLpLraaottdiffuMcMt.,iooentt.aall..J EETfofffseeicccttossl ooSffcippee2rr0lfl1uu0oo;rr3oo5oo(cc4tt)aann5o2oi7icc-3aa3cc.iidd ((PPFFOOAA)) exposure to pregnant mice on reproduction. J Toxicol Sci 2010;35(4):527-33. 6 22334433..00000066 3M_MN02585052 3M MN02586052