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POLYMER PROOUCTSDEPARTMENT EXPERIMENTAL st a tio n
PERSONAL AND CONFIDENTIAL
c c : A. J , Dahl B. W. Karr h L. J. Papa Frai file I .C.
- 353 - N1UC0
- 269
May 14, 1981
TO: DR. Y. L. POWER - PPD, Washington Works
FROM: S. S. STAFFORD
ANALYSIS OF BLOOD SAMPLES FOR PERFLDOROOCTANOATE (Job No. 810-190; PRAL Nos. 81-1420-81-1467; Notebook Nos. E22514.E26238)
As requested in your letter of 4/8/81 to L. J. Papa, the 48 blood samples submitted then have been analyzed for perfluorooctanoate (Cg). Results and sample identification are given in the attached cable.
As noted there, the analysis was done using a gas chromatographic method specific for C* (Lab Method Number ES-567) but results have been reported as ppm ? for comparison with total organic fluorine analyses. Precision is 10% relative standard deviation over most of the concentration range, somewhat less at the lowest values. The lower limit for quantitation is 0.007 ppm F (0.01 ppm perfluorooctanoic acid), with a detection limit of a. 0.004 ppm which can be distinguished from the reagent background but not well quantitated.
Please contact me (772-4440) or L. J. Papa: (772-2745) if you have any questions regarding the analyses. General questions on blood sampling can be directed to J. W. Raines or L. F. Percival.
Attachment jah
Keywords: Parfluorooctanoic Acid P exflootooctanoate Blood Analysis GC
There's a world of things we're doing something about
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TABLE I CON'OSNTaAT'rON OF ?H:R.-LCOROCCT/Q.,Oa T2 IN SLOOP (l )
Sample PRAL No.
81-- 1420
Date Sampled 4/1/81
81-1421 ~ . 81-1422 81-1423 81-1424 81-1425 81-1426 81-1427 81-1428 81-1429 81-1430 81-1431 81-1432 81-1433 81-1434 81-2435 81-1436 81-1437 81-1438 81-1439 81-1440 81-1441 81-1442 81-1443 81-1444 81-1445 81-1446 81-1447 81-1448 81-1449 81-1450 81-1451
4/1/81 4/2/81 4/2/81 4/3/81 4/3/81 4/6/81 4/6/81 4/6/81 4/6/81 4/6/81 4/6/81 4/6/81 4/6/81 4/6/81 4/6/81 4/6/81 4/6/81 4/6/81 4/6/81 4/6/81 4/6/81 4/6/81 4/6/81 4/6/81 4/6/81 4/6/81 4/6/81 4/6/81 4/6/81 4/6/81 4/6/81
P.R.No.
Name
REDACTED
REDACTED
GC Analysis late Analyzed
4/11/81 4/15/81 4/11/81 4/11/81 4/11/81 4/11/81 4/13/81 4/13/81 4/13/81 4/13/81 4/13/81 4/13/81 4/13/81 4/14/81 4/15/81 4/13/81 4/14/81 4/14/81 4/14/81 4/13/81 4/14/81 4/14/81 4/15/81 4/24/81 4/14/81 4/15/81 4/15/81 4/16/81 4/16/81 4/16/81 4/16/81 4/18/81 4/16/81
[Cg], ?/g
0.078 0.074 1.5 0.013 0.048 0.62 0.13 0.072 0.051 0.11 0-061 0.19 1.0 5.1 0.44 0.052 0.23 0.11 0.17 0.31 0.054 0.077 0.31 4.3 0.64 1.3 0.14 0.57 0.18 0.15 0.83 3.8 0.22 (c)
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TA3L I (CONT"D) CONCENTS riON OF ?XPL" CF.QOCTAN'OATE IN 31000 (a)
Sample PRAL NO. Dace Sampled
ai-1452
4/6/81
81-1453
4/6/81
81-1454 ~ _ 4/6/81
81-1455
4/6/81
81-1456
4/6/81
81-1457
4/6/81
81-1458
4/7/81
81-1459
4/7/81
81-1460
4/7/81
81-1461
4/7/81
81-1462
4/7/81
81-1463
4/7/81
81-1464
4/7/81
81-1465
4/7/81 '
81-1466
4/7/81
81-1467
4/7/81
P.R.No.
Name
R E l )'"JuPT11cun
X
\ '-
R E' TTED
GC Analysis Date Analyzed [Cp ], pg ? % bloo'i^
4/16/81
0.019
4/18/81
0.11
4/18/ai
0.14
4/18/81
2.1
4/18/81
0.19
s 4/18/81
4.3
4/20/81
4.5
4/20/81
0.81
4/23/81
1.7
4/20 & 4/24/81 4.5
4/20/81
1.9
4/23/81
2.4
4/20/81
0.10
4/20/81
0.47
4/24/81
3.6
4/20/81
0.092
(a) Analysis as described in Lab Method ES-567 ("Determination of Perfluorooctanoic Acid in Blood, Gas Chromatographic Method" , S. Stafford, 4/3/81), using the packed column GC analysis with perfluoro-n-octanoic acid as calibration standard.
(b) Although the analysis is specifically for perfluorooctanoate (acid or salts), concentrations are given in ppm fluorine for comparison with the results of total organic fluorine analyses, (ppm F 0-688 x ppm perfluorooctanoic acid) Estimated uncertainty is + 10X relative standard deviation. The lower limit for quantitation is 0.007 ygF/g. The detection limit is 0.004 WgF/g, but concentrations In that range cannot be veil quantitated and are reported as < 0.007. "None detected" is reported for samples with (Cg] < 0.004 ppm, which cannot be distinguished from reagent background.
(c) In GC analysis of this sample one unusual large peak was observed in the region of interest, but no interference with the Cg peak was apparent.
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