Document bRQMDLLjgwQkoDJKDd58Dv9D
AR RAG -- 1348
Telomer Research Program AGC pe
= Clariant PIER ------------------------------
Report Titles Jn ivo Rat Micronucleus Assay Author(s): Gregory L. Erexson, Ph.D Contractor: Covance Laboratories, Inc. Vienna, Virginia Study DIantiteisa:tion; October 18,2001
CInomLpilfeestioOnc:tobJearnu2a3r,y22050,1-300N2ovember 19, 2001 tShteudmiytoOtbijcecatppiavrea:tuTsobeyvaelxuaamtieni8-n2gAblocnoehomlarfrorowinpvoilvycclharsotmoagieinciecryactthirvoictyyteasndi/normadliesruption of
CRL:CD(SD)IGS BR rats for micronuclei.
dMoasteeorifailstahned0 M(evethhiocdlse:0.G5r%ouapqsuoeofumsamleethryatlsc(eSl/lgurloosuep)),w0er.e a1d0m0i0n,iosrte2r0e0d0amsging8l-e2oArlalcoghaovalgkee bcyocdlyopwheoisgphh.amiAdeproksgi.tiveAtcobnottrhol2g4raonudp o4f8rhaotusrrse,cSeirvaetds farsoimngelaecohraglroduopsewoefre60samcrgificed and bone mPaCrEmoNwCEwas(peoxltyrcahcrtoemdatfiocmertyhtehrioicay.tesS)li(dneosrwmeorcehrproempaatrcedearnydtshcroroecdyfctoeerl)mircartoinouwcaleslcaonudnttehde t(hsecocrreidteartialefaostrathpeosfiitsitveS0re0seproyntsherobceyitnegstohne cdeatcehctsiloindeo)faAsssaasytiaccaclelpytasnicgneifcriictaenrtiaiwncarsezmseetinwith smipcornosneu.cleated PCE's for at least 1 dose level anda saisticaly significantdose elated oFrin2d0i0n0gsm:glNkog.let3h-a2liAtylcoorhsoilgndsidofnoctliinincdaulcetoaxiscaittystwiecraelyscsiegniinfitchaentraitsncgrievaesne iinn emiitchreorn5u0c0l,ea1t0e0d0. PreCsEponsaet daenmyoonfstrahtidnosgethleevseelnssitetsitveidt.y oTfhtehepoessittisvyestceomn.trol material showed the expected (Data table follows.)
Does not contain TSCA CBI
1
TRP 23-Apr-03
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Conclusion: 8-2 Alcohol is considered negative in the at bone marrow micronucleus assay. under the conditionsofthis assay. Publications / Presentations: A) Covance Study 22900-0-454 OECD, 1/25/02. 8)Resulscited in: Kennedy, G. L. Jung, R., Iwai, H., Shin-Ya, S., Murphy. S., Drow, N., Finlay. C.. Donner, M., Erexson, G, and Stankowski, L., Jr, "Genetic Toxicologyof-2 "Telomer B Alcohol". Toxicol. Sci. 72(5-1):209:2003.
Does not contain TSCA CBI
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