Document bR7k9yQewQobog47yXeE8beZ

Kovember 3, 1975 Dr. Harry Slnolalr 150 lut 42nd Strbet Hew York, H.Y. 10017 ,. < < , < ' . ' ' ' r' ' re s POBa Daar Dr. Slnolalri Dr. Oeorge Roush dlseussad tha raeant oonvaraatlon with you regarding Morksrs handling POBa (AJKXJLOM). Va have conduotad lifetime feeding atudlaa In rata with 3 or thasa aatarlals, AROCLORS 1242, 1254 and 1260. Dm original reports ara quite volualnoua. Should you daslrt to saa copies of than, we shall ba plaaaad to make than available to you upon your request. In tha Interin, I aa enclosing copies of 3 summary reports dealing with tha liver pathology of rata fad thasa coapounda, Thase unwary reports Include histopathologic observations on new sections from all rat livers which ware in these studies. This reaasessasnt of the findings was prompted by Dr. Klstorough's findings of carcinomas In tha livers of Sherman strain rats fad AXOCLOX 1260 for approximately 21 months. Tha pathologists who reviewed tha liver sections from the Charles River strain of rats used for the 3 AX00L0X8 In the Monsanto study reached the same conclusion that had been drawn earlier. That la, while there was severe Hear damage at high exposure levels, there was no Indication of carcinoma In the livers. Should you desire to dlscuse these findings further, or If you would like to see the original reports, please feel free to oontaot aw directly. Sincerely, Oeorge J. Levlnakas, PhD Mgr., Environmental Assessment and Toxloology Akp eno. 001 Dr. Oeorge Roush, Jr. MGN5 095004