Document bOv686Bobybvp8Z6xX6n5pdYo
Toxicological Summary
PFOS
Dietary Chronic Pilot Reproductive Study: Northern Bobwhite Test Substance: Perfluorooctancsulfonate (PFOS)
Structure: Test Remarks: METHODS
h1e-pOtcatdaenceasfullufoornoi-cpaoctiads,si1u,m1,s2a,lt2,,3C34A.S4,H5,257.96,56-,319,-73,8.8.88Tw6ha.es9s%tteobtryesdLubuMsntdSaenr,caem"ibHsi-eaNnMwthRci,otneadnipdtoiewoldnesemraenn(td3aplMuraLnioatlyty#wsiass21td7e)ec,thenriTmqhiuenesedsatmopplee
Method: ASTM Standard E1062-86and `Type: Dietary Reproduction
FIFRA
Subdivision
E.,Section
71-4.
`Year: 2000 in-life Species: Norther
phase, 2000-2001 Bobwhite (Colinus
analytical phase, virginianus)
2003
for
final
report.
nEoxmpienrailmecnotnaclentdreastiigonn:s Concurrently, a control
oAfdu1l8t, group
wb6a.os2b,wmhoariint1te7a.iq6nueapdiplmo,nwewareentonew-extiprgoehastteeddfofrteoead.PpeFrAOifSotderionsfisxtihxewewdeeikeetsksoa.tf
r0`exspgporesocustrsiev,eneqecuxrapoiolpssfuyr.roemTrthehgeeimc1eo.ns8taruonntldila6n.W2depe1pk7.m620tp,rpeaamttmwtehrnietcagthrmetoniutmpesgrtwoheeurypesaelwusteohraweneimrzaeeidenutatanhidannesiduzbeojdnecattnheded
eenvveaaclltuuoaapttsieiodendwoe(feTkatlhbyel.edaB1t)ea.cawEuafssfeedctothsneeotniwnoatdlwulootwesherepadatroahst,eesbaowndealryyesweetsei.rgmhTitnhaaetnefddirfsateteasdniaxcloywsneisesukmesvp,atslituoaatntisewtdiecarallel
`daetxaamicnoeldledcattead furpomtthhreocuognhtrWoleeankd 617.f6orppalml ttrreeaattmmeennttgrgoruopupss.fromTWheeek`ssc6con(0d 2a0,nalysis
dpAohdsouitlnotgs.tqiumaAuillastuwibeosnre.te obCfrooenusggeghqstuceoinnlttlloeyc,treeidpnridotudirauticintoginvWeofepeehkgasgsel1apayrinindogr6b1eo0gfatthnehduotrnesisetntgwetorhfeetfahienrsatsltwyuzedeaydkfboyo.fr
`cPeoFnlOdlpSeoc.itnetds,E,giginnscclulubadaiitdnegdd,uergiganngpdraodrudecpatriyoodnu,pceterimivboedryesotnadvrpiioanbiignltiostyn, wthehaertecsheacbcivoalnltduya,dteahdye.alotfh,WRaeenepdrkosduruvcwitveiarvlee,
gawrpeoprurepo.xeivmaLalituveaeltreydw1e2iingwhtehteiskss.weegrgNeeccorrheoocrpotsr.ideesdOfwffeosrrperailplnegnrefwcoetrromepesdmiaeodinnqtouafaiiflns.epdriInongnadfndroiontmtirocne,aactsheadtmrpfeelaeetdsmefonoftr
Fliavberri,cibursains,akmipdlneesy, examination
wgeornead,colplreocvteendtrifcurloums,
agdaulllt
blanadd.dero,ffasdpirpionsge
ffoirssuhe,istaonpdatBhuolrosgaicoafl
1
2004
ttAhitemet1hoe8feannneddcorfo6W.p2seyp,eoklmiv6et,rrsbealwtoemoredentsaalgmsrpooluceposlslwaeecnrtdeedwceoforlrleeccththeeemdnifceraulotmhaananallilyzsseiudsr.vainvdinngecardouplstiebidr.dsAtfrtohme
also collected cuthanasia and
from adult birds necropsy at the
in the control and beginning of Week
17.6 ppm treatmBelnotogdrosuapmspleprsiowrertoe 20. At necropsy, liver samples were
Abadlldsoiootdcioolnslaealclmtype,ldetfsirsosuwmeesardefulrtocmobilrl1de0sctfoeofdrfscpfhrreiomnimgcawle1r0aelyocsfoiflssl.percitPnergdiofrfrrtooomeutehaacnhasiatorefattmheeonftfsgprroiunpg.,
haneamlaycsyitse./plAaltlelbeltofordactcioolnlse.cted
from
adult
and
offspring
m was
sceapcahrattreedatimnetnotsgerrouump
for and
Table 1. Experimental Norther bobwhites.
design
for
the
dietary
chronic
pilot
reproductive
study
with
Treament Expose
(pm)
Period
Endpoms Bamined
(week)
Control
20
15 ) 62
6
Health, body morphology and
weight, feed histopathology
ocfonbsoudmpytioorng,ans,greogsgs
6 production, embryo viability, hatchability, off
176
2
health and `membrane,
syuorlvki,vaall,buPmFinO,Sancodncbelnotordatsieornusm
spring ionflaivdeuri,t eagngd.
offspring quails
`Test Bird Age: Adult quail (approximately 30 weeks old at exposure initiation)
Number of Replicates: Five replicates (pens) per treatment group
Quail per Replicate: One male andfemaleper pen
Feed study basis,
and Water: to both adult once a week.
Food quail
and and
owfaftperrinwge.reFpereodvicdoendsuamdptliiobnitwuamsdumreiansguraeldpohnasespeorfptehne
dAneatleyrtmiicnaeld bMyonrietvoerrsien-gp:haPseFOHSPLcConacenndtrmaatsisonsspeicntrfoemeedt,ry.liver and serum samples were
mpSuetlarttfiiosprtlmieceacdlomMtpeoatrheivosadolsun:atpUerpoocsiengdnucirofemicpwalnaettsidouinsfoefdfertetonhcecetosemstpb,aeartneweatenhanelyttsrrieesoaatftmmveeannrttieagfnfrceoceutp(s.ANODVunAn)etwta'ss
The only
student's Ttest was used to the control and the 17.6 ppm
tmraekatemesnttatgisrtoicuaplscwoemrpearciosmopnasreidn.those
s with control. instances where
Average Daily Intake (AD)of PFOS for each treatment group was estimated using data
2 C2005
bbfeortdowymeeweneaictghhhetpmeadnalteian atwnhedarteftermaeaavtlemereanpgtaeidgrreooduvpew,ritwhtiihtnehoaduutpreatnta.ikoinnFgooiofndtotchaoecncssoutumundptytpioaotnnednatintadhle addAiufDlfIterqewunaaciesls calculated as follows:
ADi(mghday=Av= ersgeA= FveeerdsmgCeoBnosuudmyptnwioeniQ g (fegciddb)iR rd day) )on, pny
(Equaiont)
`Test used
fDoiretwePerkelpyarparteipoanra:tiToenstofdtihetes
fwienarledpirte.pared
by
mixing
PFOS
into
a
premix
that
was
RESULTS
IMnetaesmautrieodnalDiLeidt.. tCoonccoenfnitrrmatPiFonOsS: coCnhceemnitcraatlionasnailnystehse (LOQ) was equivalent to 0.879 ppm, wet weight during
diweetrs.e Week
Tchoendluicmtitedof bqyuanWtiiltdatiiiofne 1ofthe study) while for
caWocenrtoerskosl6rdeiptelhtiescaLstehOosQwaemwdpalesnso)1p.fr41resoepmnpcmte.heotfTesththeedipteeetsrstcersnautnbsgrteeadcnocfveerrooimres9ot7oh.fe0rmtacotor-1ic1xl3u%stip.nigkeAcsnoam(lpayovseuernsadgsoe.df
`hSTaahdmepmmleeeaassnucormleeldaescvtuaerldeufdeosPtFvheaOrtSifricaconangtceieodnnotfrfraotdmiioe9nts5PftFoorO1dSi1ec1tos%nucosefentdtrhaientintoohnmesisnftarulodmyPwtFehOreeS:trceoantcmeennttragtrioounpss
<LOQ, 1.8, 6.0 and 17.6 ppm in feed
afAonnrdal7y17sd.ia6syspopfamvdeidrtiaegtseatdmrpe1al0tem0se%n,ctosl1,l0erc3ets%epdeacftnirdvoe9ml8yE.%codefrtshaeftWreebekin1g, Dhealyd 0atvaamlbuiesenftortetmhpeer1.a8t,ur6e.s3
fgMeroaortuthpaerldiultoresissn,gatnthhedeseCsltsiuindgyin.csalwWOehbriseleercovsnaestviiedoreanrlse:dquNa1oi0lbaweduelrttheemnororettsaeulldittwioieftshpoehcnecuawrderaeodrr iafnonodatlnoylrestpireoennastmmaaentndet `angogrrmeaslsiionnaptphaetaroacnccuerraendddbuerhianvgiotrh.e courseof the test. All other quail were found to be.
2bA)ds. uelrItvneBmdaoldienys,fWetemhiaeglrehestw:farsAotmabasonatythosft6tcaahlneldyt2rs0eiagwnteimefeikncsta,ngtrno(opupa<sdv0we.hr0se5en)ercfeofdemucpctastriooennd ibtnoodbcyoondwtyeroiwlgeshitg(Thwatebrliene mIttahleweas1s,7.a6copNnpocmluOtdbresedearttvmhaeabntltetghriAsoduvrpeerdasutecWteiEoefnfke:citn6 CabononddcyaetnwtWereiatgeihkotn2w0(aN(s8O.tAr8Ee%aCtr)meednwutac.tsrioodlnaettfeedrr.omminFceoondrtrtaoodlubsle)t. td6he2atnepropmrimenqePudaFltOoStboea1n71d.76.t6phpeppmLmoPwFPeOFsSOt,S.ObsTehrevaNblOeAAEdCverfosre fEefmfaelcets Cwoanscednettraetrimoinne(dLtOo AbEeCg)reawtaeer
3
C2606
rFee8deucdatnCidoonn6ss2uinmppfptomiooduncc:aotnNmsoeunmttprtegiartomoneunpatts-trahetelsaWeteeeedxkepfof6s.eucrtesWsh,ointlhefeostoehderrceeodnuwcseturimeopntsstiawotenisrtweiecnraloeltyncosoitngesndiifdiinecratenhdte trareplepaaattrimeveennltty.rrleeadlruagtceetdiiondcnrueeaatsteoWetihneekfleae6cdkactoontfasheusdmeopstteiw-oronesdipnoosntehssee cmroeanlytartoihloanvsgheriopbu.epeTantheathsicsiogntnsiiemfiqecuaiennnctceeerovafoltfhaye Mrcoeoramctpomaverenertd,gtfroeoetudhpastcoownbasssuemrpsvitegidnoianftiacWatenctelkiynsrP5eoFdruOc7Se.dtrfTehrautomsme,nttthhagetrfioenuepdtshceaotncoWsnuetmerpoktli6ognrwoerurapeteagitrneWaaletlecrPktEhG6a,Sn bSfooenbesdwihctioetnnestuqmaupnatdiliosinantrstaithceeas l1ml7ey.a6ssiupgrnpeimdfiacPtaFnWtOeS(epkt<re0af.to0mr5e)nthtreeadssuacmcteoiomtnpraeirantemfdeenettdo gcqrouonauipslsu.miptTithhoeenrecaowmntaortneg)a. [gteorcnedatbtoimlrendat-ndadaty,1W7er.ee6skpepscpt2im,ve3lt,yr.e4a,tmB6e,anst8e,sdaanotndWre1Se.esukltTs2h0efrwaoevmreertaheg2e8W8efeeegkd fc6eoensdtsabutiimrsptdit-cidaolanyanraaanltdyessi2si4,m4tthee 2N.OAEC and LOAEC for feed consumption was 6.2 and 17.6 ppm, respectively (Table
eTxapbolsee2d.
tAovPeFraOgSe
daily in the
exposure, diet. A
feed
consumption,bodyand
liver
weightof
adult
quail
Treatment Gpm)
ADI (mgkgbody
FC (gfeed
weightday _foirdiday
Sex
Body Weight (g) Week6 Week20
Liver weight
Control <LoQ 82M 203%7 21657 340220446
18
017% 0.007
2042 MFo232142%:1142 232421 37.650415%01521945
Fo2l1e36
63232 1.668
62 176
059% 0.066
23*3 M 207:11 Foose
53.6628344400.560856
20005 23042 M1966 197027 2.527% 0359
sacrificCoemaodte W1ee7kpo066..2Ae4l9slmvaeluness awreergeisveneae3 mdea3nsWFaen_ddk2s3t30an1dwa%rhd1d4eBviatFi2on2s4.0%3S3 T6r85e11n88e0n
* `1A7c.v6oenprsapugmmeptiDgoarniolutpysr,IoungkheW(eAeDIk;6mfgorPthFeOS1.8 Kg3bdody6.2wpeimghgrpoeuepsdaanydotfrPouOgSh Wweaeskba3s0edforanshaevceroangteolfoosd
AstFeoroidskcoinndsiucmatpetsionstbatistaicoalnWdsiefefekre6ncddeaftaom thecontol rcatment at p< 0.05,
WWLieevecekkr 26W0,e.iigtOhwnta:lsySnitonhtceepcooandstuslritobllqeuaantiodl cf1o7rm.o6pmaprtpheemt1ht.er8seeaatnmtdewno6t.s2trwpeepartmemetsnrtteatagitsrmtoeinucatplsslywteoervtaehluetaetcreomdni.tnraotMlesadlaaett
twbreoeibagwthhmtietnwcthgqeurnaoiuclpoimwnpeatrhreeend1o7tt.o6stcapotnpitsmrtiocvlaselal(ytTmsaeibnglnteifh2i)a.cdanatIlnsytfadetiimfsaftleiercesan,ltlylfisrvieogrmniwcfeoiincgtarhnottlssr.iendTuhtchutesi,o1nf7o.ir6n mpiavplemes
NQuOaAiEtChewLaOsAgEreCatebrastehadnoonr edqeucarlea0s.e1d7.li6veprpmwe.ight was 17.6 ppm, while in females, the
4
12607
pu6`.oGatrwolrhseislwlaePetareteqdhu0aosilulbotjgrieeynca:tttemAhdedenuttcl.ootngIqtrnurocaosiilsldaeninennccdretoohp1esf7ys..16"m.8aplapAnlmdl 6tf.ri2enadptipnmgemsnttswreevraetermeecnostnassmiwipeelrreeeddsaa1tc0rWitfeieecepdr3an0t.Weocehxk
the 17.6 ppm treatment group
testes was note uring the ross necropsy
qsTuaeamnipl,ljuetvdheinsainlldeossosufbpwjraescitnegcdon(tsaoipdrperorosexsdimn(aoetcerbloeypsiy1n.2ciwdWeehniktlasel frequency of loss was quivlent across eat
ofalendad)thuefnrrroTomonstsceadwcahtsotrorebasetesmreevnentdtgirnsoujhpoovweemrene
ment levels. No other ndings ee
considered to be treatment related in theoffspring.
t{oHheviesasrtrteeyod,wpoeabrtrrheaioinnnl,aoodgtuoyrlr:tebabTuimrhresednasrtecfowaelblleraeeitccetudnesdoleflisneoisomiqnousnatsiholebisncoetforhfnvesteporidlvieinarng,ntdahktei1da7nn.ey6y,pofpprotvheeenatPrtFicOeuSnlu.sc,ogTarnllaoblndadecder.r,
ssoierzmjeiunviinefnemiraloleuesbsotbfuufbwuohlmietetd.hieam1He7to.ew6re.pveprWm,hittrlheeearteamewdnaets,craaennadsintihcnirsetawessaatsedisnicpstooismhzeleaiisntscesicdudoeennwssciieos.tnteoe5nfstdsoewspeisthceknrnpasoeen1r.ss
tsirhineincpsciredooedbtnushcceeetrrievovaefwtiadposehncasarseersaemrslaeaelgtdlirvetseseassm0itposlnPaesFiOszSinez.oerrwemoalafsalbtgiperrhdedyassetieaeostlctotghiiinscahtlreepaht1em7ne6ontmpe(onNom~nS,)e.chatemhoefnrs,ei.qguneinHcfoyineoesreeorf
cSopmerpmaarteodgetnoccsoinstodildmnaoltesa.ppear to be adversely tafsfeccatend miontthbee 1d7e.t6epnmpimneedanteen scheeres
vepRfreafopedscrautocsdsttouianoctnitesitwmvihbceaerlnylRyoecssouvimilgantpbisaif:lriiectTaydn,httheo(artthc<ewhaec0bro.ni0et5lr)yno,rolehgdarPutoFccutOhpil.Soi-nntgInnehtaeaadelddtiht,icofanfn,cdtthsseurroevniwvaebbroielbiwnthoy.iPteEWOiqueaiilqeuoegssg sg1ri8ogunpip.fpicmanWtthrdeeianftmferrneetpn,rcotedhuiwscetrwiveaesobeasndecproovniesndetaqsumewonencrgeeaoenfxypforfeetwsehshreeedePgnaFgussOmbSpbeeeerrcnaeogtnfmvtseaiegnatebtslsT,oerwnshotmbiesaayspkeaosrmsdpteamnrteecrynhe v0tioacb6oinl2tirtoyplwsp.amsWnPoFhtOioSb,stehterhrvieesdweaifnsfetcahts1iw7ag.6shprnpeodtmuccttoirnoesnaitdimneerneetbdrdyoovevirabeillaitteyd aSmioncneg dusalesdxunigne trHeaattcmhelnitngelaantdedOeffffsecptrsinogn Rtehseulbtosd:yInweicgohmtpaorfiseotnhetro hcaotncthoiln,g tohrerJeuvewneirlee bnoabPuFnOeS ftQourraeiaoltfmf(esTnpatrbsilnewgh3e)en.ndpcIonionmatdpsdaiwtraieosn,gortehcaoteneetrrwhoealrneloinveoreeqvfuafaleulcets1s.0o1n7B.6ajusvepednpiolne tlihveesrewreeigchot,fosroean1y 1PFsOS
s r2608
TableTr3e.aMtemeanntliver and body weighBtoodfyofWfepirgihntg(gb)obwhite quail. A Juvenile Liver
"Control 1.8 ppm.
Hatchling 61205 5605
Juvenile 175%10 1751
Weight (8) 37460339
1672.6ppppmm
650720056
17945
375640453 4.985% 1367
1738
3.429%0.495
"BodyTaEndrievseerewdigahtmefaonsjuevdenisleasnwedredmeessarend pproximately12 wks posehach. 04%
Blood and Liver POS Analysis:
R1esuPletsflofuoctuhteancthseumi(carlfaOnaSl(ysis of blood and liver `accumulated PFOS in a dose dependent manner (Table 4).
showed
that
the
adult
quail
dTuraibnlg4eth.eSpuilmomtaPrFyOoSfarneaplryotdiuccatliornessutlutdsy.fo*r adult quail liver and serum samples collected
Treatment (ppm) Control
Exposure duration
(week) Sex
20
M
Tiver Cone. gg)
018820093
Serum Conc, g/mL)
1.80
6
MF 035<2L200Q268
7302449 11683735.10178
620
6
MF 011290.3400.018899 7373322147030
176
20
F M
0.142006 290291
3224097 199583
T"T Lihevterweaingdhtesbearrsuims.ocoTnhaeenLirrOaQisofnosr lewivererreewdaavser0.a0ge1edtlnfgoFrrnsdadcafornr isdetr1uedm3e6Swa+emapr1l0.se601(1vR3nT p
445475 Se
Smfnaereloamimnbgrieaahntdeodnccsosrnttotaarsnnosddlaaarrtnddc,edcae0iav.mi0eianttitohmnaedfnovtat.lhuiesBgorboheulpeo,wptithcheaevcaaslmuleiynt0it.cha0rl0e0el0oi5umtuiooqfgfue(vnotnleihvaaeisfoosn)afm(aphnleLdeOsGvta)FhleouneroTsoafemsmpeleeesrppweerese
all serasampleswere rep0o0r1tedugsb/oLv)e wthaesLuOsGe.d for values eported a< LOG. Al other vssomessay
wcAoennarcleeyntttiyrcpaailtciarolenlssyulbt2esttswoheoe9wn4emdtailtmeheastangtdrheefarteeemrwaaltsehabanobmtwahhratikteoedbsqdueiariflvf.eerdeInincnemfaielnemsali,lveelsrivawenirtdchoisnnecretunhtmeraPstFaimoOenS.s Cbtoornebcawethnmitetrneattqiguoranoisulpsho.basdeTrshveeerdusmainPmeFfOewSmaascloensocbessneatrmrvpaetldieodfnosrftrshoaemtruwtmehreceons4caetmnoet2ra4ttriteoianmtsemseonftgrPegaFrtOoeSurp..thaMnaTtlhheee trreelaattimoennsthigprobupest.weeSnerluimver(0alnidverserartuimos croanncgeendtrfartoimon0s.1w1asto v2a6r2iaibnlemaalneds dainfdfefrreodma3c.r2ostso
6
C2609
b1o5b0whiintefeqmuaaliels.wereT:he serum to liver relationships for PFOS concentrations in adult
Mak: Female:
SSeerruumm PPFFOOSS ((ungg//mmLL))== 1951..665338 ((LLiivveerrPPFFOOSS,, uugg/gg))-+4.58.4543575
Ri 0.5997 Ri=0,3200
TaTnohdeesaxenaramluyimtniPecaFltOhdSeatcraoenlacaletsniootnrisanhtdiiipcoanbtseebdtuwttehtaehtnatthPteFhreeOsSewadesaxtaapowdseoursreee sdaeenxpdesnptdeiecsinsftuiecinacconrndecaehsieghilnybvoatrhialbilvee,r
sesetriummatceodncaevnetrraagteiodnasilcyolilnetcatkeed (fArDoIm)eoafchPFweOaStmbenyt.adulAtnquAaiDlIwwaasscoumsepdarienntdrtathitosiloainnvsae,rlyatsnhiesd
tbheecaeunsveirtohnimsepnatr.amTehteerriessuusletsd oafs tahemeraesgurersesoifoenxapnoaslyusries concentrations and ADIare given below:
that for
adult both
sbeirrdusmmaanyd
elnicvoerunPteFrOSin
Male:
LSievreurmPPFFOOSS(u(gg//g)mL=)1=.296042.9(4A8D(IA,DmIg,/mkgg/bkogdbyowdeyiwgehitgdhatyi)da+y)
+ 9.344 03118
Ri= 0.8964 R%= 03233
Female:
LSievreurmPPFFOOSS(u(gu/gg/)m=L)0.=712439.1(4A8DI(,ADmIg,/mkgg/bkogdbyowdeyigwheti'gdhatyd)a-y0).~0923.5198
R= 0.4080 R=03871
tThhaetsmealreegsraescsciuomnulmaotdeedlsgraearteerincoangcreenetmreantitonwsitohf tPhFeOsSeriunm:botlihvetrheraltiivoerdaantda in comparison (0 female bobwhite quail. However, the time-depe
that showed blood serum
PFOS serum
by males and liver
PaFndOSfecmoanlceesntrisatuinoknsnocwonu,ldannodt
the be
impact
of
egg
ndent accumulation of production on female
determined from this study. Without
additional depuration liver PFOS
cpohualrdmancootkibneectoicndudcattae,d aat concentrations should be
tmhiosretimea.ccuOrvaetrealle,vailt uwaatsiocnonocfluPdFedOSthatupstearkuem evaluatedon a sex-specific basis.
and and
1 Pe dlu Chemical
aoncaultysaenstdouf(r1a2r--wSeeckusol)od(juvenile
quail
serum
and
liver
PROS concentrations persist in juvenile quail (Table 5). Juvenile
samples
indicate
that
{0 Lo
PFOS post-hateh, contributions into
rtahteheergtghefirrosmeraudumltanfdemliavleer
PFOS quails.
concentratqiuoanisl wweerree ennottierxlpyodsueed These concentrations represent.
cthoantcewnhtircathiornesmaairenendotinretphreesjeunvteantiilvee qoufaitlhsatafftoeurnd12inwequeakisloifmgmredoiwatthelaynpdosdtep-uhraattciho.n, The
7 [aaitsXs)
Tjaubvelneil5e.quCaoinlcentrations of PFOS in the liver and serum of 12-week old
Treatment (Copnptmro)l
Tver Cone <Le0leQ)
Segru/mmCLo)ne. <L0Q
6128 176
001<8L2500Q0156 0.0593 +0.0417
00.2030234+00.00813988 0413 0.1140
ThRweTetcLwoiOngQehnftroarbtaloisvne.rswiasr0.0e1 gsgeaannmdefsoderssweiuh
sndird devon it was 0.01 ug,
Des
goers
caTnoanolcyesanistssreaistnsicolnutsdheeadnadqlulacngtthgietyadotalitvkae,ciornnecclleauntdtiironangtsihcoianptsa,bteahtartweewgeranesssjaiuobvnoenvainlatelhyeslilisivmeiwrtasoafncddoentdseuecctrtiueomdn.(PLTFOoODi)Sg
bauvteralegsesctghganyotlhkeaLndOj,uvefnirloemseearcuhm PanFdOSlivterrePaFtmOeSntcognrcouepn.tratTihones raerlea:tionship beamees
SLievreurmPPFROOSS((ugu/gg/)mi=)0.=0001.0(0E7g(Eygoelkyo,lkg, /ugm/m))-0..000040364 RR==0909806072
Tcohnucse,ntjruavteinoinlse liver and serum PFOS concentrations ar highly correlated with egg yolk
TJthuheveegnsrieelaretuelmsitvteorcolanincvdeernstrereraluattimiooPnnsFshObieSpisncwoganscm:eenatsruarteiodnsininqcuraeilasefdroimnathdeos1e7.d6eppepnmdenditetmapnensertweirth Serum PFOS (ug/ml) = 4.3533(liver PFOS, ug/g) + 00720 R= 0.6041
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Yolk (g/mL) = 24.696 (ADI, mg/kg body weight/day) + 8.4986 R= 0.7748
Yolk (ng/mL) = 6.012 (In Serum, pg/mL) + 28.342 Yolk (ug/mL) = 5.4416 (In Liver, ug/g) + 49.920
R= 0.6637 R=0.8207
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------
10
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Rinabalcehr7o.nMiceapsiluortesmteundty ewnidtphobiontbswhaintdeqausasoicliaantdedtdhiecitraorfyfsNpOriAngE.C and LOAEC values for PFOS
Endpoint A
Dictary NOAEC
Dietary LOAEC
ADULT
MoBrotdayliwetiyght
Fema=le1s72617.6 FemalNeost=apNpolticaapbpllei:cable.
LFieveedrcwoenisguhtmption
Males =6.2 Female6s2> 17.6,
Mal= e17s.6 Females = N1o7t6applicable:
HiGsrtoospsaptahtohloolgoygy
Males =6.2 Femal2e1s7>6 17.6.
NMotalapep=slic1a7.b6l.e Females = Not applicable
OReFpFrSodPuRcItiNvGe
Mal2e1s7=66.2
NMoatlaepspl=ic1ab7l.e6:
H1a4t-cdhalyinsgujrvuivveanbiilleitbyody weight
22117766
Juvenile liver weight
NNoott aapppplliiccaabbllee::
owneetko]exapnosu1r7e..6AplmcEosnsca ebasrneedpootrnterd2o0naeswctektiewxepioogsh1urtnbe7,o6sWyH.E 13 67 ppm eNlost applbiecnatbloer TE
LOreAsuEltCs for miss om sisal infant reduce in body weigh, crweght disputes
n
Coca
Tinaabclhr8eo.nNicOpAilEoLt satnuddyLwOitAhEPLFOvSa,luesi various matrices in adult and offspring bobwhite quail
Measuresof PFOS ADULT MALES
Exposure
A
NOAEL
LOAEL
ADoDsIe((ppppmm/d)ay) Serum (ug/ml)
62 0.579
176 200
Liver (ppm) ADULT FEMALES
73 129
199 290
ADoDsIe((pppmpvmi)day)
17.6
LiSveerru(mu(gu/gg/)mi)
200 445
OFFSPRING
137
YLoivlekr((uugg/mgl))
331
pASleecrtounmcaenndta1t7i.(uog/mnl)smrgepPorRteOdSon
ssuwlettwseribghatsbeadsoisw
0.059 Weck0304,1w3he
5
PPTellae
based
on
Week
6
SNLroOeA1ErneLdpoLvrltoeuwdcsafsfomceamsvaaullreuesedsbtafisosersdudeioenvaalbunoedds,yADweTaigrh,eivperiweigaa. dietary concentrations.
dai Serumand liver effect values
Yolk PROS concentration taken rom week .
ht and histopathology results.
DATA QUALITY
Reliability: Kiimish ranking = 1
REFERENCES:
sGtauldlyagwhietrh, tSh.eP.N,orVtahnerHoBvoebnw,hitReL.. Report Lab Request No, U2723.
WiBledalviefres,Int1e.r5nat(i2o0n0a3l),.LtPdF,OSP:rojAectpNiloo.t
4r5e4p-r1o0du4c;t3ivhe
Gallagher, Amana Analytical
S.P. quai
(2001). live for
aEnxatlryascitsiounsionfg
Laboratories, Inc. Study No.
pHoPtLasCs-iEumlePcertlrluoosrpoMoracatcayeneSspuelcftornoamteetrfyr.omCeqnuatirle
023-041
(`GCmaeelnmltabrgerhaAennrea,,lyaStl.iPbc.uaml(eL2na0,b0o1ar)na.dtoyroiEelxskt,rfaIocnrtc.iaonnSatlyuosfisPoustiansgsiHuPmLCP-eErlfelcuotrroooscptraanyes/uMlafsosnastpeectfrroommeteryg.g
dy No. 023-065,
OTHER Last changed: 05/05/04
2 "2015
