Document bOoyKYvmnr58g819gb55E9Rg

WIN FerR-0704-00373 September 17,2004 Our sa arr En hon, 70 Boo oem, Newark, E 19714.0080 33 Via FederalExpress 3 EHR -q0- 372 * Document Processing Center (Mail Code 7407M) Room 6428 Attention: 8(e) Coordinator Office of Pollution Prevention and Toxics 33S2.01 ECnovnisrtiotnumteinotnaAlvPer.o,tNecWtion Agency, ICC Building. To {7 ~WashingDtC2o0n46,0 en a ~9 cal ) 7 Dear 8(e) Coordinator: a 2 Ammonium Perfluorooctanoate SEHQ-0381-0394 "This leter is submitted "For Your Information" to supplement the leter of September 7, 2004 `submitted by Mr. Edward E. Shea, representing MIC Specialty Chemicals, Inc. (Attachment I). tOhveermalele,titnhge eleltdteratantdheaIcncnoamtpaMonnyticnhgatnriipnrVeiplolratgearoenaAnuagcucsutra2t0e-2r1ef,l2ec0t0i4o.n Oofurthceonpcrloucseieodnisngfsroomf the meeting are summarized as follows: 1. No effects were observed on the general health of the workers at the Miteni plant. 2. `Naoppacrheantngselsighitn aclltienriactailonchoefmsisetrruym plairpiadmelteevrelss wtehartecoorbrseelravteedd wwiitthh etxhpeoseuxrcee.ptTihoneocfauasne _B_= 3. A`alntdhboiuoglohgitchael soibgsneirfviceadncceohafngtheiss oabpspeeravratitoonbies ucnocrlreealrataendd rweiquhireesxpfousrutrhee,r demonstrate a causal association with exposure o these substances. aintaldysoiess. not "= --o 4. AfvoerraocgceuspeartiuomnlaelveelxspoosfurPeF,OaAndwesriegnhifiigchaenrtliynthhiegMhietretnhianwolrekveerlss trheapnorhtaevdeibnetehnergeepnoerrtseld ""===== population. = For the sakeof completeness, we are submitting with this leter a copyofthe data slides that "= 3suMmmaacrtiuzaellyDulPodntt'hse pirenlailminaanraylyasniaslysoifs tohfethMeisneirumdaltiapidindcaltuadi(nAgtttahcehm3e7ntbIl)o.odWepanroatmeettehrast ""=== : DmeunPtoinotnesdubisneDqru.enCtolsytau'nsdetritporoekpoarnt.iAnfdeepresnedeeinntgtsthaetisptrieclalimainnaalryysiasnaolfystihseosfetrhuemselirpuidm dliapaidodnaltys,, ~=~= raenfderpernecseedntiendMro.urShperae'lsimIitnearrywaenanloytseisthatftohlelowAiunggu:st 20-21 meeting. With respect to the data 1. rtIhenevTeaapbllleadentt1hwietosprhrkoeeusdledncwbeietohnfotbPeoFdtOhtShapte(rpafenlraufloylrsuieonsraotooefcdttnhceooimsceprosauuonlffdtosnh.aeteT".PhFeDOr.As-vCeeoxrssptgoaesecosdne"frgiurrmomuePpdFatOlhsaAot caovnecreangterawtaison-- w0.a5sp~pm16wiptpham rwaintgheo&fr0a.n0g6e.3o3f p0p.0m4.-9I2sphopumldabnednfootredsethrautmnoPFanOaSlystehse for these same perfluorinated compounds was undertaken for the sera of workers in the non-PFOA/non-PFOS area ("Non-PFOATM group). 2 tm wten , 279325 2. There are a number of caveats that are germane to the interpretation of the data in Teno `addition to the fact that workers were exposed to both PFOA and PFOS; notably: + TTaherE e. ng liV n sdvsenI PPFFOOAendd7E05CSoE ttss TTohtoo,rvwee family history, diet, and lifestyle; data on these factors were not available for dependent variables: total perfluorinated compound (the sum of PFOA + PFOS), PFOA 4. The data have been analyzed in terms of a linear model; however, other models may fit As indicated in Mr. Shea's letter, DuPont has additional ongoing studies that may enable a study, "Ammonium Perfluorooctanoate: Cross-Sectional Surveillance of Clinical Measures of General Health Status Related to a Serum Biomarker of Exposure and Retrospective Cohort Works plant, Currently we are analyzing the data and expect to issue a final report by year's end. various nuclear receptors, e.g., PPAR in an effort to better understand the biological activity of coyote retention of PFOA eps fo in the serum, thus accounting fDut ss or the observed ilo bth correlations. `Agency when available. Oletacedago SAIL. cromen ts JR (302) 366-5260 (II) "DuPont Statistical Analysis of Serum Lipid Data of Miteni Workers" 2