Document bDbXgYXwEXzG0keGe280zEa6

ST08520S2 THE JOURNAL OF INDUSTRIAL HYGIENE AND TOXICOLOGY V M A< ri1 VOLUME 31 JANUARY, 1949--NOVEMBER, 1949 / PUBLISHED BY THE WILLIAMS & WILKINS COMPANY Baltimore, Md. S T 0 8 52063 CONTENTS OF VOLUME 31 JANUARY, 1949. NUMBER 1 Tb* Toxic Properties op Xylldine and Monoethyianiline. I. Joseph P. Treon, William B. Deichmann, Howard E. Sigmon, Howard Wright, Sylvan 0. Wiihcrup, Francis F. Heyroth, Karl V. Kiiimiller and Clara Keenan.................................................................................................... . .Toxicity and Potential Dangers op Cyclotrimethylenetrinitraiqnz (RDX). W F von Qettingen, D. D. Donahue, H. Yagoda, A. R. Monaco and M. R. Harris................................... Experimental Studies on the Action op Silica Gel Catalyst Administered to Guinea Pigs by Inhalation. C. U. Demehl, Carl A. Nau, T. M. Frank and H. W. Neidhardt..................... .Pneumoconiosis prom Fuller's Earth: Report op a Case with Autopsy Findings. Henrik 0 Tanning.......................................................................................................................................... Intervertebral Disc Injury: An Analysis op One Hundred and Thirteen Industrial Cases. Henry C. Marble and William A. Bishop...................................................................................... Maximum Allowable Concentrations op Atmospheric Impurities. Philip Drinker and Warren A. Cook.......................................................................................................................................... . .Penetration op Air-Borne Particulates Through the Human Nose. TI. H D Landahl and T, Tracewell.................................................................................................................................. . , ., .Rangb-pinding Toxicity Data, List HI. Henry F Smyth Jr Charles P Carpenter and Carrol S. Weil........................................................................................................................................... Book Reviews...................................................................................................................................... 1 21 32 41 46 51#-- 55 60'"' 63 MARCH, 1949. NUMBER 2 . .Absorption and Elimination op Carbon Disulfide in Man. J Teisinger and B Soucek............. 67 , . .Physiological Response op Man to Ammonia in Low Concentrations. Leslie Silverman J L Whittenberger and Jan Muller....................................................................................................... 74'"' .Short-term Toxicity Tests on the Mono and Di Methyl Ethers op Hydroquinone. Harold C Hodge, James H. Sterner, Elliott A. Maynard and Joan Thomas................................................. 79^- . . , .On the Theory and Pathology op Carbon Disulpide Poisoning. R H DcMeio H Brieger and M. H. F. Friedman........................................................................................................................ 93 .An Improved Animal Dusting Apparatus. Frank Princi,'Franklin Church and William McGilvray 106 . .Comparative Toxicity op Methacrylonitrile and Acrylonitrile. W A McOmie................. 113.-- .Observations on the Acute and Chronic Toxicity op Toxaphene in the Dog. Robert W Lackey............................................................................................................................................ 117*" Book Reviews..................................................................................................................................... 121 MAY, 1949. NUMBER 3 Acute Pneumonitis in Workers Exposed to Beryllium Oxide and Beryllium Metal. Joseph C. Aub and Robert S. Grier................................................................................................................................ 123 The Absorption and Excretion op Fluorides. III. Further Observations on the Metabolism op Fluorides at High Levels op Intake. Edward J. Largent and Fronds F. Heyroth............... 134 Benign Pneumoconiosis in a Tin Oxide Recovery Plant. Harold C. Cutter, William W. Faller, Joseph B. Stocklen and William L. Wilson................................................................................................... 139 The Physiological Response op Animals to Respiratory Exposure to the Vapors op Di isopropylamine. Joseph F. Treon, Howard Sigmon, Karl V. KitzmiUer and Frands F. Heyroth.. 142*"^ Local and Systemic Eppects Following Skin Contact with Phenol. A Review op the Lit erature. William B. Ddchman..................................................................................................................... 146 Observations on the Percutaneous Absorption op Toxaphene. in the Rabbit and the Dog. II. Robert W. Lackey.'........................................................................................................................................ 155 Toxicity of Thioacetamide in Rats. Anthony M. Ambrose, FloydDcEds, and Leland J. Rather___ 158 iii ST0852Q61* IV JOURNAL OF INDUSTRIAL HYGIENE AND TOXICOLOGY The Hazards Associated with the Use or Lead Arsenate in Apple Orchards. Lloyd M. Farner, C. D. Yqffe, N. Scott and F. E. Adley................................................................................. 16^ Dust Particles and Aqueous Aerosols............................................................................................ It Boor Reviews............................................................................................................................................ 17^ JULY, 1949. NUMBER 4 ( Nutritional Factors Affecting the Toxicity op Some Aromatic Hydrocarbons with Special Reference to Benzene and Nitrobenzene Compounds; A Review. Maurice E. Skils and Leonard J. Goldwater......................................................................................................... 175 Occupational Poisoning by Alkyl Mercury Compounds. KarUDavid Lundgrm and Ake Swcnsson............................................................................................................................................ 190] Human Problems in Industrial Machine Design. Theodore F. Hatch........................................ 201; Effect of Para-Amtnobenzoic Acid on the In Vivo Oxidation of Hemoglobin. Samuel S. Spicer 204 Heinz Body Formation In Vivo a Property of Methylene Blue. Samuel S. Spicer and E. C. Thompson........................................................................................................................................... 206 Physiologic Response of Animals Exposed to Airborne Ketene. Joseph F. Treon and Howard E. Sigmon, Karl V. Kitmiller, Francis F. Heyroth, Waldo J. Younker and Jacob Cholak........ 209 Cutaneous Cleansing for Industrial Workers. C. Guy Lane....................................................... 220 Medical Control of Beryllium Poisoning. Irving R. Tabershow, Cyril Dustan and Leonard J. Goldwater...................................................... ...................................................................................'. 227 SEPTEMBER, 1949. NUMBER 5 The Physiological Response of Animals to Trichloroacetonitrile Administered Orally, Applied on the Skin or Inhaled as a Vapor in Air. Joseph F. Treon, Karl V. Kitmiller, , Howard Sigmon, Frank Dutro and Waldo Younker................................................................ 23j The Industrial Physician and Workmen' Compensation--Current Trends in Compen- ] satton Legislation. Theodore C. Waters.................................................................................... 251 Range-Finding Toxicity Tests on Propylene Glycol in the Rat. Joan F. Thomas, Raymond Kcsel and Harold C. Hodge.......................................................................................................... 256 Carbon Monoxide-Hemoglobin Levels of Workers Employed in Airplane Engine Repair Shops. Herman I. Chinn.................................................................................................................................. 258 Incidence of Diabetes Mellitus among Applicants for Employment at an Industrial Plant. Gordon M. Hemmett.......................................................................................................... 261 A New Method of Evaluating Disability in Silicosis and in Other Conditions of the Lungs and in Circulation. Pfemysl Pelndf...................................................................................... 264' The Industrial Physician and Health Insurance--Retirement, Group Life and NonCompensable Disability Insurance. Gilbert W. Fitchugh...................................................... 277 Non-Occupational Berylliosis. Merril Eisenbud, R. C. Wanla, Cyril Dustan, L. T. Steadman, W. B. Harris and B. S. Wolf............................................. .............................................................. 282 Burns of the Skin Produced by Trichloroethylene Vapors at Room Temperature. Clarence C. Maloof.................................................................................................................................... 295 .Dermatological Injuries by Ethylene Oxide. Richard J. Sexton and Edward V Henson......... 297 The Effect of Bal on Experimental Lead, Tungsten, Vanadium, Uranium, Copper and .Copper-Arsenic Poisoning. Lehman M. Lusky, Herbert A Braun and Edward P. Lang......... 301 Book Reviews.................................................................................................................................... 306 NOVEMBER, 1949. NUMBER 6 Subacute Vapor Toxicity and Range-Finding Data for Ethyl Acrylate. Urbano C. Posxani, Carrol S. Weil and Charles P. Carpenter.......................................................................................... The Toxicity of Methyl and Ethyl Acrylate. Joseph F. Treon, Howard Sigmon, Howard Wright and Karl V. Kitmiller.......................................................................................................... ..Solubility of Lead Compounds in Human Pleural Fluid and Blood Serum. Gordon C. Harrold 327 i ST08520S5 , CONTENTS Qgjtcsxs Head Injuries and Litigants. George H. Byslop............................................................... v 336 Tb* Assay or Acute Vapor Toxicity, and the Grading and Interpretation op Resuits on 96 Chemical Compounds. Charles P. Carpenter, ffenry F. Smyth, Jr. and Urhano C. Pouani. 343 Heaith op Woreers Exposed to Gaiena. E. A. Bdden and L. F. Garber............................................ 347 FaiAUTY and Hxness Caused by Ethylene Chloshydrin in an Agricultural Occupation. Albert F. Bush, Herbert K. Abrams and Harold V. Brown.......................................................... 332 AJSnnnr op Workers Exposed to Talc and Other Dusting Compounds in the Rubber In dustry. Warren L. Hogue, Jr. and Frederick S. MaBette............................................................. 359 High Concentration--Short Time Exposures and Toxicity. Barry Griffith King................ 365 Boor Review:........................................................................................................................................................... '.375 : ST0852066 maximum allowable concentrations of atmospheric impurities* Philip Drinker1 and Warren A. Cook* NE OF the most effective proponents of Othe prevention of industrial disease was Sir Thomas Legge, former Senior Medical oxide typify the comparatively few that give what might be called a measurable reaction when breathed by man. Inspector of Factories in Great Britain. He laid Obviously maximum allowable concentrations down four axioms of which two can well be (MAC's) for such substances are the easiest to considered as engineering rules of guidance in determine. Reactions are acute and well defined. our problems of today (1): On the other hand,' substances like silica, radium "If you can bring an influence to bear external or benzol can be breathed for months or even to the workman (i.e. one over which he can years with the victim entirely unaware of the risk. exercise no control) you will be successful; if Obviously again, such substances involve you can not or do not, you will never be wholly appreciable difficulties in defining their MAC's successful. and any values require much long-range correlation `Tractically all industrial lead poisoning is between exposure and pathological effects. Their due to the inhalation of dust and fumes; and interpretation definitely falls into the practice of if you stop their inhalation you will stop the industrial hygiene and is an art rather than a poisoning." Legge (1) believed that 2 mgs. per diem was about the maximum safe dosage for man and if he breathed 10 cubic meters in a day then his safe concentration in air was 0.2 mgs./cu.m. science. It would be a serious mistake to consider any of these MAC's as precise. Their correctness varies pretty much with the toxicity of the substance in question--they are reliable for acute exposures to In the United States, Dr. Alice Hamilton (2) substances such as CO and HS and they are continually and effectively has pled for clean air no more than approximations in the case of chronic as the most important method of preventing exposures to slow acting dusts like granite. industrial disease. J. S. Haldane, a physiologist, had the unique distinction of serving as a president of the Mining Institution of Great Britain, an honor any engineer would welcome. He set the pace for preventing carbon monoxide poisoning by defining the relationship of exposure and activity (3). Later work by Henderson and Haggard (4) at Yale University established very clearly the fact that safe concentrations of such a gas as CO could be defined accurately. K. B. Lehmann (5) in Germany showed the relationship of zinc oxide fume concentration to the febrile response of healthy humans. With a background of Leh mann's original work, Drinker, Thomson and Finn (6) defined exposures to ZnO and human responses in much the same fashion as had been done previously for CO. Substances such as carbon monoxide and zinc Duration of Exposure In the application of MAC's to the evaluation of an occupational disease exposure and to the control of a health hazard, the duration of exposure must be included. Most of the values presented today contemplate continued subjection to the atmospheric contaminant over the entire work week without injury to health. If the work week is longer than normal the concentration should be kept at a level lower than the accepted MAC, roughly in inverse proportion to the increase in time. However, if the exposure is for a period shorter than a normal week, great caution should be observed before permitting concentrations to be propor tionally greater. The extent to which the MAC can be exceeded, * Received for publication September 18, 1948. A paper presented at the Ninth International Congress on Industrial Medicine, London, September 14-16, 1948. 1 Professor of Industrial Hygiene, Harvard School of Public Health, Boston, Massachusetts. 1 Director, Division of Industrial Hygiene and Engineering Research, Zurich Insurance Companies, Chicago, Illinois. if at all, for short, repeated exposures depends upon the characteristics of the substance. Where the physiological effect of the contaminant is largely irritative as with such a gas as sulfur dioxide, the tolerable concentration for brief exposure is very little higher than that for pro- 51 ST 0852067 52 JOURNAL OF INDUSTRIAL HYGIENE AND TOXICOLOGY [vol. 31, no. l longed exposure. Although an MAC of 10 parts of sulfur dioxide by volume per million parts of air is considered without effect for an indefinite period, a concentration of only twice this value would cause coughing in a short time. Even with substances which exert systemic effects on the body, experience has demonstrated that it is dangerous to permit concentrations to rise too high even for compratively brief periods. Only two hours exposure to a concentration of 300 parts per million ethylene chlorhydrine caused fatal poisoning although it is probable that continued exposure to 5 parts per million would be borne without injury. Exposure to the silicosis-producing dusts can be greater than the accepted MAC's for short periods without injury to the lungs but greatly excessive concentrations even of such a contaminant are to be avoided as noted by Mavrogordato (7) as early as 1923. Where the exposure varies, the concentrations can be averaged within limits and again depending upon the characteristics of the contaminant. One can not average high and low concentrations for severe poisons like CO because a single acute exposure may be disabling or even lethal. But it is not unreasonable to average chronic exposures to substances like quartz or even radium. Thus four hours exposure to dust concentrations of 60 million particles per cubic foot and four hours to 20 might be considered equivalent to eight hours at 40 million particles. That sort of averaging has been used in estimating silicosis risks and now is being used in gauging exposures to radioactive fission products. MAC's for Siliceous Dusts The concentration of dusts which can be inhaled without injury depends not only on the duration of exposure but also on the free silica content. With in limits the higher the free silica percentage, the lower the MAC. New York State has developed a very effective series of codes governing work with siliceous rock. Their codes for rock drilling and rock crushing (8) have accomplished a vast amount of good and have set a pattern for preventing silicosis. New York permits dust counts of 100 million particles per cubic foot for dust from rock con taining less than 10 per cent free silica and counts up to 10 million for rock containing more than 10 per cent free silica. The significant item is the fact that free silica is estimated in the parent rock and not in the air-floated dust. Estimation of silica in the parent rock is routine in mineralogy while such estimates in air-floated dust are difficult and time consuming. In certain operations such as shaking out castings in the foundry, the air-floated dust may be significantly different in quartz content from that of the parent material. In such a case, it is of course essential to be informed on the quartz content of the atmospheric dust. Sensory Reaction vs. Poisoning We have heard some acrimonious discussions on whether MAC's should indicate sensory reactions or definite toxic manifestations. For instance, acetone vapors are perceptible at around 200 p.p.m. and somewhat annoying to the uninitiated at about 500 p.p.m. We know of very convincing data that frequent and long exposures to values above 2000 p.pjn. are completely without measur able effect upon man. Such concentrations are substantially below those which cause mild anesthesia but are approaching those of possible inflammability. Carbon tetrachloride, an ex tremely useful and important solvent, often induces nausea and vomiting in concentrations well below those which cause chronic poisoning. It is submitted that a nauseating atmosphere is hardly a fit place in which to work. Hence a demand is sometimes made that concentrations of carbon tetrachloride vapors be kept substantially below the level set by the usual criteria for selecting MAC's. Zones of Toxicity In a recent paper Schrenk (9) reviewed the development of procedures used in establishment of maximum allowable concentrations and the criteria on which they are based. A list of MAC's of some 140 common substances together with basic references in support of the values is given by Cook (10). An effort was made in this latter paper to indicate that the values are not precise by listing them only as round figures. In a series of papers on the response of guinea pigs to various solvent vapor concentrations, Sayers, Yant, Schrenk and others (11) plot on double log paper exposure time versus concentra tions. They show several zones, the first which causes death within 24 hours, the second which elicits a serious response, and the third which is ST0852068 ST08520 BOOK REVIEWS lynonCAL AMS SCIENTIFIC DEVELOPMENTS BELATED 10 1BX ASBESTOS DTOUSTBY IN QEEKANY. Board of II Trade. German Industry. F.I.A.T. Final Report ' Ho. 1070 (March 23), 1947. London: H. M. r. Stationery Office. 4s. 6d. This report is a description of the machinery and jgftaUatiaa of the German asbestos industry which is andiemi to be of interest to American industry, and jg * supplement to previous reports especially Fiat final Report 460 and Bios Final Report 404, Item 22. The main problem for the German asbestos industry is regarded at present as one of lack of material, in which the British Zone is not so badly off as the Ameri can. The report consists broadly of three sections, cne dealing with industrial plant, another with prob lems of dust control and a third with some experiments rpii by German scientists during the war to prepare a synthetic asbestos. The present position with re gard to the plant and installation is solely an engineer ing problem. The preparation of a synthetic product has been held up by the collapse of German industry, and not a great deal appears to be known about it, but the basic idea seems to have been "gelling" of sodium silicate with hydrochloric add, washing out of the gel to remove NaCl by liquefying it under steam pressure, evaporating the solution to 14 per cent SiO, with the addition of 5-10 per cent sugar, introducing a pawing process and finally ageing the fibre, washing the sugar residue and drying. The section on dust control has a direct bearing on general industrial hy giene. For many years before the war, insurance against the risks of dust and accidents was compulsory. The use of respirators was recommended only in extreme cases, reliance being chiefly placed on an effident dust control organization. The report gives a translation of the regulation for Dust Prevention in Asbestos Processing Plants issued by the German Government in 1940. This lays down general engineering precautions for dust control, with detailed instructions as to the protection of machines and the provirion of exhaust equipment [Many of these are already in use in Britain, but the details are too technical for abstraction.] An official center for advising on dust prevention, especially in the case of the installation of new plant, was provided by the Government Children under the age of 18 were not considered suitable for dusty occupations [no details are given, however, as to the regulations for their exdusion]. It was forbidden to eat, or to remain, h dust-endangered rooms during rest periods. Out door clothes were not to be kept in workrooms and work clothes had to be cleaned at regular intervals [time not stated). The writer of the report also interviewed Dr. Luise Holzapfel who had had charge of an organization in Berlin for the investigation of rilicosb problems, be fore the collapse of Germany. She stated that the and her staff had been engaged for some time on the isola tion of organic silicon compounds. Two important ones had been discovered, but their chemical compo sition had not been completely determined when the war ended. One was a silicon compound of the lipoid group obtained from the longs of patients suffering from rilicosb accompanied by tuberculosb, the other was a Si-N compound present in normal blood. The isola tion of these compounds had been extremely tedious, taking from 2 to 3 years and when the Russians took over that section of Berlin they had ordered the de struction of all material on the ground of risk of infec tion. Dr. Holzapfel considered that there was no risk of tuberculosb provided that silica metabolism in the body was normal, and she regarded disturbed fat me tabolism in undernourished workers as a predisposing cause of tuberculosis. She was of the opinion that the compound isolated from healthy blood might have some therapeutic value both in tuberculosb and tuberculosilicotic patients. The striking resemblance be tween the tissue of a silicotic lung and vulcanized rubber suggested to her the presence of long-chain organic silicon oxygen compounds, probably formed when the fresh surface of quartz grains reacted with some unknown constituent of the blood. The pres ence of oxygen was necessary, she believed, for that reaction to take place and she further expressed the view that "a compound in which the silicon atoms are completely surrounded by organic radic&b probably cannot cause rilicosb because such a compound will be insoluble and unreactive". Dr. Holzapfel had tried to cultivate the tubercle bacillus on SiO, gel containing various nutrient substances, but without success. The writer of the report states that further informa tion on the two substances mentioned can be obtained from the Kaiser-Wilhelm Institut fur Silikat Forschung in Berlin-Dahlem. The substance formed in normal blood had 1.3 per cent SiOj, 6.5 per cent N, but no iron or cholesterol; it was water-soluble, strongly al kaline, with a melting point over 250 [presumably Centigrade] and had been isolated from the lecithin fraction in the blood. The second was a water-in soluble substance from the lung tissue, and could be concentrated in the ester fractions. The lecithin com pound, on the other hand, was almost completely absent from lung tissue. In rilicosb the melting point of the extracted mixture of ester-free fat was found to increase in relation to the severity of the disease. Early cases of rilicosb yielded a mixture of melting at 45 whibt the material extracted from more advanced cases melted at 72-81. Extraction of silicotic lungs 171 ST 0852069 ,172 JOURNAL OF INDUSTRIAL HYGIENE AND TOXICOLOGY M. 31 no. gave a higher proportion of lipoid* (esters, free fatty acids and phosphatides) than was obtained from hesilthy lung tissue.--S. Roodkouse Gloyne, Bull, of Hygiene. The PXAcncE or industrial medicine. By R. A. Lloyd Davies, M.D., M.R.C.P., with a chapter on the hazards of coal mining by G. P. Keaiinge, M.D., D.IM. Reviewed in Chemistry and Industry, February 5, 1949. The principles and practices or modern cosmetics. Volume n. Cosmetic materials: their origin, char acteristics, uses and dermatological action. By Ralph G. Harry, Leonard Hill, Ltd. 17 Stratford Place, London, W.l, 1948, 479 pp. This book presents in alphabetical arrangement a list of materials commonly used in cosmetics or for cosmetic manufacture. Included are discussions onthe origin, characteristics, uses and dermatologic ac tion of cosmetic materials. Thus one may pass from "abracols" to zinc sulfate and find information on formula, molecular weight, occurrence or manufacture, physical and chemical properties, B.P. standard, use in toilet preparations and dermatologic action. The appendixes include discussions of methods of U. S. Toilet Goods Association for testing for certain sub stances and a list of the coal tar colors certified by the Food and Drug Administration. Although the book is written in England, it, unlike many others, has equal usefulness for those who reside outside the United Kingdom. Thus, this volume should be of consider able usefulness to those in the United States who are interested in the preparation or identification of cosmetics and cosmetic ingredients. It is not intended for the practitioner, but it will be found practical for the pharmacist, chemist, teacher and others who have interest in the details of cosmetology.--J. A. M. A. Detoxication mechanisms. By R. Tecwyn WilliamsJohn Wiley & Sons, Inc., New York, 1947. 288 pages. Price 85.50. This is an excellent review of the literature on the metabolic fate of many organic compounds that are of interest to the industrial toxicologist. This book should be in the library of everyone interested in toxi cology.--Albert 0. Seder. Nuclear radiation physics. By R. E. Lapp and H. L. Andrews. Prentice-Hall, Inc., New York, 1948. 487 pages. Price $6.00. This book is the outgrowth of an elementary manual on radiological safety. In its present form, however, the majority of the text is on fundamental nuclear physics. There are 5 chapters of the 18 in the book of specific interest to industrial hygienists and health phyticj,^ These chapters cover nuclear radiations, ionization chamber instruments, Geiger-Muller counters, radio, don measurement technique and health physics. ^ The book presents the basic principles of the iriw^ underlying atomic structure and nuclear fission. I is a useful book for reviewing fundamentals for peopfe with technical backgrounds entering the field of nnJ dear energy production and protection. The chapter on health physics describes the biologi. cal effects of radiation, permissible radiation, radiation standards, safety requirements and monitoring tech.'' nique. The appendices also present useful data on isotopes and safety rules now used by the U. S. Atomic Energy Commission. Manufacturers of radiation instruments' are presented in the last appendix but this is the type of informadon which will require frequent revision sis will the description of such instruments. Industrial hygiene personnel will find this book a useful addition to their libraries.--Leslie Silverman. History or tactory and mine hygiene. By Ludwig' Teleky, MJD. Columbia University Press, New York, 1948. 342 pages. Price $4.50. This historical treatise, while retaining a well- balanced perspective of occupational hygiene throughout the world from the Paleolithic Age to present times, indudes much of the strong, stimulating personality of its author. The major developments in the field have occurred since the turn of the century, and throughout the book are evidences of Teleky5* active participation over this period, injecting warmth and readability into its pages. We tend to lose sight of the stem pioneering which proceeded the state of responsive management attitude to industrial hygiene existing today until we read of Teleky5* experiences of not so long ago. By 1906, regulations in the large cities of Austria had driven the white phosphorus match industry into the small villages. An example of this industry's hostility to investigation of its occupational disease situation in those days is the treatment accorded Dr. and Mrs. Teleky. After a long day of walking through the hamlets of the Bohemian forest in search of cases of phosphorus poisoning, they reached the village inn owned by the match manufacturer only to be turned away because of the purpose of their presence in the area. Teleky does not leave us with any impression that the need for striving for improved working con ditions is past or that we should rest on the gains made to date. He stings any who may fed that everything is as it should be with the reminder that there is no statistical evidence to support any contention that great progress has been made, and he points to the still existent need for "laws and regulations thoroughly worked out and enforced by well trained inspectors." After a foreword by Dr. Alice Hamilton, itself a ST0852070 (VOLUME 31. INDEX TO TEXT AND BOOK REVIEWS (Asterisk denotes book reviews) Herbert K. see Bush, Albert F. , Assay of Acute Vapor Toxicity (Carpenter, et al.).................................................... 343 ^-finding toxicity data. List HI (Smyth, faL)............................................................... 60 Idol, op. cii................................................... 60 ye meld. Assay of Acute Vapor Toxidty (Carpenter, C. P., etaL)................................. 343 ; anhydride, op. eit.................................... 343 itrlle, op. cit.............................................. 343 acetone, op. cit.................................... 343 , op. cit............................................... . 343 ___ , methyl and ethyl, the toxidty of Fffteon, Sigmon, Wright and Kitzmiller).... 317 jhacnte vapor toxidty and range-finding data flat ethyl (Pozzani, Weil and Carpenter)........311 rfanltrlle. Assay of Acute Vapor Toxidty (Carpenter, C. P., et al.)................................. 343 .rionltrlle, metnscrylonitrile, comparative : toxicity of (McOmie)..................................... 113 f, F. E. set Famer, Lloyd M. .sola, aqueous, dust partides and (A review ' md reply) (Davies and Dautrebande)........... 169 ' ate, John N., BeU, G. H., Boddle, G. F., Bowler, R. G,, Buckell, Monamy, Cheese* man, B- A., Douglas, T. H. J., Druett, H. An Garrad,Jessie, Hunter, Donald, Perry, K. M. A., Richardson, J. D., and Weir, J. B. de V.: Industrial fluorosis, a study of the hazard to ynen and animals near Fort Wiliam, Scotland........................................................... 306 [cultural occupation, fatality and illness caused by ethylene cnlorhydnn in an (Bush, Abrams, and Brown)........... ....................... 352 Ur-borne particulates, penetration of through the human nose (Landahl and TraceweH).... 55 Jiilr hygiene, studies in (BourdiUon, Lidwell, Lovelock, with Caw*ton, Colebrook, Ellis, ,. Van Den Ende, Glover, MacFarlan, Miles, ... Raymond, Schusterand Thomas)................... 308 Airplane engine repair shops, carbon monoxidehemoglobin levels of workers employed in ~ (Chinn)........................................................... 258 a'Alden, John L.: Design of industrial ezhaust gS systems. Second edition............ .............. 121 fjAtkyl mercury compounds, occupational poison- mg by (Lundgren and Swensson)........... . . 190 .vinyl acetate, Assay of Acute Vapor Toxicity jZi (Carpenter, C. P., et al.)............................... 343 L Range-finding toxicity data, List III (Smyth :t aL).................................................................... 60 Allyl alcohol. Assay of Acute Vapor Toxicity r l (Carpenter, C. P., et a!.)................................ 343 ARyl chloride, op. cit....................................... 343 Allyl ether of propylene glycol, Range-finding toxicity data, List HI (Smyth,et aL).............. 60 ylidene dlacetate. Assay of Acute Vapor ri. Toxidty (Carpenter, C. P.,et al.)................... 343 [Ambrose, Anthony M., DeEds, Floyd, and Rather, Leland J.: Toxidty of thioacet- amideinrats.................................................... 158 nonia, Assay of Acute Vapor Toxidty (Carpenter, C. P., et al.)............................. 343 nonia, physiological response of man to, in low concentrations (Silverman, Whittenberger and Muller).................................................... 74 Amyl mercaptan, Assay of Acute Vapor Toxidty (Carpenter, C. P., et aL)................................. 343 Amyl tnehlorosllane, op. cit............................... 343 * Andrew!, H. L. see Lapp, R. B. Aniline, Assay of Acute Vapor Toxidty (Carpen ter, C. P., et al.).............................................. 343 'Annual report of the Chief Inspector of Factories (Great Britain) for the Year 1947. January 1949. PubL by H. M. Stationery Office........................................................... 306 'Asbestos industry in Germany, technical and identific developments related to the (German Industry. Boaro of Tfcade).............................. 171 Atmopsheric . impurities, maximum allowable concentrations of (Drinker and Cook)........... 51 Aub, Joseph C. and Grier, Robert S.: Acute pneumonitis in workers exposed to beryllium oxide and beryllium metal.............................. 123 BAL, the effect of, on experimental lead, tungsten, vanadium, uranium, copper and copperarsenic poisoning (Lusky, Braun and Lang)... 301 * Basic pnnaples of ventilation and heating (Bedford)........................................................ 63 'Bedford, Thomas: Basic prindples of venti lation and heating.......................................... 63 Belden, E. A. and Garber, L. F.: Health of workers exposed to galena.............................. 347 * BeU, G. H. see Agate, John N. Benzene, Assay of Acute Vapor Toxidty (Carpenter, C. P., et al)................................ 343 Benzene and nitrobenzene compounds, nutritional factors affecting the toxidty of some aromatic hydrocarbons with special reference to (Shils and Goldwater)...................................... 175 Benzyl alcohol. Assay of Acute Vapor Tox idty (Carpenter, C. P., et al.)......................... 343 Berylliosis, non-occupational (Eisenbud, Wanta, Dustan, Steadman, Harris and Wolf).............. 282 Beryllium oxide and beryllium metal, acute pneumonitis in workers exposed to (Aub end Grier).............................................................. 123 Beryllium poisoning, medical control of (Tabershaw, Dustan and Goldwater).............. 227 Bishop, William A. see Marble, Henry C. Blood serum, solubility of lead compounds in human pleural fluid and (Harrold).................. 327 * Boddle, G. F. see Agate, John N. * Bourdiilon, R. B., Lidwell, O. M., Lovelock, J. E., with Cawston, W. C., Colebrook, L., Ellis, F. P., Van Den Ende, M,, Glover, R. E., MacFarlan, A. M., MUes, A. A., Raymond, W. F., Schuster, E., and Thomas, j. C.: Studies in air hygiene......... 308 B wler, R. G. see Agate, John N. Br.vun, Herbert A. see Lusky, Lehman M. Briefrr, H. see DeMelo, R. H. Brown, Harold V. see Bush, Albert F. * Buckell, Monamy see Agate, John N. Bums of the skin produced by trichloroethylene vapors at room temperature (Maloof)............. 295 Bush, Albert F., Abrams, Herbert K., and Brown, Harold V.: Fatality and illness caused by ethylene chlorhydrin in an agri cultural occupation........................................ 352 377 ST 0852011 378 JOURNAL OF INDUSTRIAL HYGIENE AND TOXICOLOGY n-Butylamlne, Assay of Acute Vapor Toxicity * Davies, R. A. Lloyd: The practice of Industrial (Carpenter, C. P., et al.).................................. 343 medicine.............................................. ............... * Davis, Russell D.: Pilot error.......................... Carbon disulfide, absorption and elimination of in man (Teisinger and SouSek).................... 67 poisoning, on the theory and pathology of (DeMeio, Brieger and Friedman).................... 93 Carbon monoxide-hemoglobin levels of workers employed in airplane engine repair shops (Chinn).................................................... 258 Carbon tetrachloride. Assay of Acute Vapor Toxicity (Carpenter, C. P., et aL).................. 343 Carpenter, Charles P., Smyth, Henry F., and Poxxant, Urbano C.: The may of acute vapor toxicity, and the grading ana interpretation of results on 96 chemical compounds............ 343 see Pozzanl, U. C.; set Smvth, H. F., Jr. * Cawston, W. C. see Bouxdulon R. B. "Cellosolve", Assay of Acute Vapor Toxicity (Carpenter, C. P., et aL).................................... 343 "Celloeoive" acetate, op. ctt....................................343 * Cheeseman, B. A. >w Agate, John IT. Chinn, Herman I.: Carbon monoxide-hemo globin levels of workers employed in air plane engine repair shops.................................. 258 Cbloroacetyi chloride, Assay of Acute Vapor Toxidty (Carpenter, C. P., et al.).....................343 Chloroallylldene dlaeetate, op. cit.......................... 343 1 -Chloro-1,1-dlfluorethane, of. cii........................343 2-Chloroethyl vinyl ether, op. cit............................ 343 Range-finding toxicity data, List HI (Smyth, et al.)................................................................... 60 1 -Chloropropane-2,3-dlol. Assay of Acute Vapor Toxicity (Carpenter, C. P., et aL)........ 343 1- Cbloro propene-2, op. cit................................ 343 2- Chloro-l, 1-3-trlethoxy propane, op. cit..... 343 Chlorotrlfluoroethylene, op. cit............................ 343 Cholak, Jacob su Treon, Joseph, F. Church, Franklin su Prind, Frank * Cole, Lewis Gregory: Lung dust lesions (pneumoconiosis) versus tuberculosis............ 122 * Colebrook, L. su Bourdillon, R. B. Compensation legislation, current trends in-- the industrial physician and workmen's compensation (Waters).................................... 251 Cook, warren A. su Drinker, Philip Copper and copper arsenic poisoning, the effect of BAL on experimental lead, tungsten, vanadium, uranium, (Lusky, Braun ana Lang)................................................................... 301 * Cosmetics, the principles and practices of modem (Harry)................................................. 172 * Currie, J. R.: Hygiene (Manual of Public Health). Third Edition........................... Cutaneous cleansing for industrial workers (Lane).................................................................. 220 Cutter, Harold C., Faller, William W., Stocklen, Joseph B., and Wilson, William L.: Benign pneumoconiosis in a tin oxide recovery plant..................................................... 139 Cyanomethyl acetate. Assay oi Acute Vapor Toxicity (Carpenter, C. P., et al.).......................343 Cyclohexanone, op. cit........................................... 343 Cyclotrlmethylenetrlnltramlne (RDX), DeBda, Floyd su Ambrose, Anthony M. Deichman, William B.: Local and systemic effects following skin contact with phenol A review of the literature................................. ... ik Treon, Joseph F. DeMeio, R. H., Briefer, H. and Friedman, M. H. F.: On the theory and pathology of carbon disulfide poisoning............................... Dermatological injuries by ethylene oxide (Sexton and Henson)..........................................297 Demehl, C. U., ITau, Carl A., Frank, T. M., and Nddhardt, H. W.: Experimental studies on the action of silica gel catalyst administered to guinea pin by inhalation___ 3j . * Detoxication mechanisms (WUliams)................172 V*! Diabetes melhtus. Incidence of, among appli- /' cants for employment at an industrial plant '** (Hemmett)........................................................261 -i Dlallyl ether, Range-finding toxidty data, List HI (Smyth, et aL)..................................... & Dlallyl maleate, op. cit........................................... <so Dibutyl phosphite, op. cit..................................... $o 1, l-Dichloro-2,2-difluoro ethylene, Assay of Arute Vapor Toxidty (Carpenter, C. P., t.aL)................................................................... 343 1.1- Dlcfaloroethane, op. cit.................................. 343 l,2JHchloroethane, op. cit..................................... 343 1.2-Dlehloroethyl acetate, op. cit.......................343 1,1 -Dlchloroethylene, op. cit............................... 343 2,2'-dlchloroethyl ether, op. cii.............................343 Dl-2-chloroethyl formal, op. cit..............................343 l ,2-Dichloro propane; op. cit.................................. 343 1.2- IHchloropropanol-3, op. cit........................ 343 2.3- Dichloro propionaldehyde, op. cit............343 XH(2-cyanoetnyl) amine. Range-finding toxidty data. list HI (Smyth, et al).............. 60 Dl(2-cyanoethyl) sulfide, op. cit........................... 60 Dlethoxychlorosllane, Assay of Acute Vapor Toxidty (Carpenter, C. P., et al.).................... 343 Range-finding toxidty data, list HI (Smyth et al)................................................................... 60 1.1- Diethoxyethane, Assay of Acute Vapor Toxidty (Carpenter. C. P., et aL).................... 343 Diethyl "Cellosolve", op. cit....................................343 Diethylene trlamlne, Range-finding toxidty data, List HI (Smyth, et al)............................ 60 Dl(2-ethylhexyl) amine, op. cit........................... 60 D1 (2-etbylhexyl) maleate, op. cit......................... 60 Diethyl maleate, op. cit......................................... 60 Diethyl sulfate. Assay of Acute Vapor Toxidty 12R1 a(nCgaer-pfienndtienrg, C. P., et al.)...................................... toxidty data, list HI (Smyth, 343 et al)................................................................... 60 1.1- Dlfluoroethylene, Assay of Acute Vapor Toxicity (Carpenter, C. P., et al.)...................... 343 1.1- Dlfluoroethane, op. cit...................................343 Dilsobutyl carblnol. Range-finding toxidty data, List HI (Smyth, et aL)...................................... 60 Dilsobutyl ketone. Assay of Acute Vapor Toxidty (Carpenter, C. P., et al).................... 343 Ran^e-finding toxidty data, List HI (Smyth, et ^ toxicity and potential dangers of (von Oettingen, Donahue, Yagoda, Monaco and Harris)................................................................. 21 Dilsopropvlamlne, the physiological response of animals to respiratory exposure to the vapors of (Treon, Sigmon, Kitznuller and Heyroth).. 142 1.1- Dlmethory. ethane. Assay of Acute Vapor D&utrebande, L. su Davies, C. IT. Toxidty ((Carpenter, C. P., et al).................... 343 Davies, C. N. and Dautrebande, L.: Dust Dimethyl acetal, op. dt............................................343 particles and aqueous aerosols (A review Range-finding toxicity data, List IH (Smyth, et and reply)........................................................... 169 al.)....................................................................... 60 ?Dj > -f' $ S T 0 8 52072 INDEX TO TEXT AND BOOK REVIEWS 379 _ ethyl-1 ,4-Dioxane, Assay of Acute Vapor Toxicity (Carpenter, C. P., et al.)........343 1----- ethyl furane, op. dt.................................. 343 ethyl heptanol-4, Range-finding ty data. List m (Smyth, et aL)............. 60 l tetrahydrophthalate, op. til............. 60 ,yl tetrahydropyrone, op. dt................... 60 nethyl tetrahydro-1,4-pyrone, Assay Acute Vapor Toxidty (Carpenter, C. P., aL).................................. 343 iyl sulfate, op. cit....................................... 343 op. dt..................................................... 343 _ ling toxicity data, List m (Smyth, etaL)................................................................. 60 a, D. D. too Ton Oettingen, W. F. T. H. J. tee Agate, John N. _ Philip and Cook, Warren A.: Maximum allowable concentrations of at- beric Impurities......................... 31 . H, A. see Agate, John N. Cyril sot Blsenbud, Merrll i Taberthaw, Irving R. J partidee and aqueous aerosols (A review jand reply) (Davies and Dautrebande)............ 169 sting apparatus, an improved animal (Prind, E> Chords and McGQvray).................................. 106 (Methyl styryl phenyl ketone), ^o-unding toxidty data, List HI (Smyth, ^ thud, Merril, Wants, R. C., Dustan, Cyril, 8teadman, L. T., Harris, W. B,, / and Wolf, B. 8.: Non-occupational berylliosis 232 pUa, F, P. sot BourdlUon, R. B. dilorhydrin. Assay of Acute Vapor Toxidty (Carpenter, C. P., et aL)...................................343 myethyl ether of propylene glycol, Range- finding toxidty data, List m (Smyth, et aL).. 60 thoxy prioplonaldehyde, Assay of Acute Vapor Toxidty (Carpenter, C. P., et al.)........343 Ethyl acetoacetate. Range-finding toxidty ' r data. List HI (Smyth, et aL)........................... 60 gXthyl acrylate, and methyl, the toxidty of S'-. (Treon, Sigmon, Wright and Kitzmiller)........317 subacute vapor toxidty and range-finding data jj for (Pozzam, Weil and Carpenter)..................... 311 Stbyl butyl ketone. Range-finding toxidty data, Lut HI (Smyth, et aL)........................... 60 Bthylene chlorhydrin, Assay of Acute Vapor Toxidty (Carpenter, C. P., et al.)................... 343 fatality and illness caused by, in an agricultural occupation (Bush, Abrams and Brown)..........352 ji Bthylene dlchloride. Assay of Acute Vapor i' Toxidty (Carpenter, C. P., et al.)................. 343 ? Bthylene glycol diethyl ether, op. dt-- ........343 & Bthylene glycol ethylether acetate, op. tit..... 343 / Bthylene glycol methyl ether acetate, op. cit... 343 * Bthylene glycol monoethyl ether, op. cit........... 343 A Bthylene glycol monoisopropyl ether, op. c..i.t............................................................... 343 lr Bthylene glycol monomethyl ether, of. dt-- 343 r Bthylene glycol mono-n-propyl ether, op. dt............................................................... 343 . Bthylene Imlne, op. cit.......................................343 . Bthylene oxide, op. dt.........................................343 dermatological injuries by (Sexton and Henson). 343 Ethyl butyl ketone. Assay of Acute Vapor Toxidty (Carpenter, C. P., et al.)................... 343 jlBthyl fluoride, op. dt........................ 343 2-Bthyl hexene-1, op. cit................................... 343 Range-finding toxidty data, List IH (Smyth, et al.)................................................................. 60 2-BthyIhexyl amine. Assay of Acute Vapor Toxidty (Carpenter, C. P., et al.)......................343 Range finding toxidty data, List III (Smyth, et aL)..................................................................... 60 2-Bthylhexyl-6-chloride, Assay of Acute Vapor Toxidty (Carpenter, C. P., et al.).................. 343 BthyUdene acetone, op. dt...................................... 343 BthyUdene dlchloride, op. dt................................ 343 Bthyl orthoformate, op. dt................................... 343 Bthyl trlchloroailane, op. dt...................................343 Range-finding toxidty data. List HI (Smyth, et .. )........................................................ Ethoxy triethoxy sUane,<>y.ctt............................ 60 * Exhaust systems, design of industrial. Second edition (Alden)................................................ 121 Exposures, high concentration-short time, and. toxidty (King).................................................. 365 * Factories (Great Britain), annual report of the Chief Inspector of, for the year 1947. January 1949. PubL by H. M. Stationery Office.................................................................. 306 * Factory and mine hygiene, history of (Tricky).. 172 Ftiler, William W. set Cutter, Harold C. Farmer, Lloyd M,, Taffe, C. D., Scott, N,, and Adley, F. B.: The hazards associated with the use of lead anenate in apple orchards........ 162 Fltzhugh, Gilbert W.: The industrial physician ana health insurance--retirement, group life and non-compensable disability insurance___ 277 Fluorides, the absorption and excretion of. HI. Futher observations on the metabolism of fluorides at high levels of intake (Largent and Heyroth)..................................................... 134 * Fluoroaia, industrial; a study of the hazard to man and animals near Fort William, Scotland (Agate, Bell, Boddie, Bowler, Buckell, Cheeseman, Douglas, Druett, Garrad, Hunter, Perry, Richardson and Weir)...........................306 Formaldehyde, Assay of Acute Vapor Toxicity (Carpenter, C. P., et al.)...................................343 Frank, T. M. see Deraehl, C. U. Friedman, M. H. F. see DeMelo, E. H. Fuller's earth, pneumoconiosis from: Report of a case with autopsy findings (Tonning)___ 41 Galena, health of workers exposed to (Belden and Garber)...................................................... 347 Garber, L. F. see Belden, B. A. * German Industry. Board of Trade.: Technical and scientific developments related to the asbestos industry in Germany......................... 171 Glyoxal tetrabutyl acetal. Range finding toxicity data, list HI (Smyth, et aL)........................... 60 * Garrad, Jessie su Agate, John N. * Glover, R. E. see BourdlUon, R. B. Goldwater, Leonard J. see Shlls, Maurice E. su Tabershaw, Irving R. Grier, Robert S. su Aub, Joseph C. Harris, M. R. su von Oettingen, W. F. Harris, W. B. su Eisenbud, Merrll * Harry, Ralph G.: The principles and practices of modem cosmetics. Volume II...................... 172 Hsrrold, Gordon C.: Solubility of lead com pounds in human pleural fluid and blood serum.................................................................. 327 Hatch, Theodore F.: Human problems in in dustrial machine design...................................... 201 *Hazlett, T. Lyle: Introduction to Industrial Medicine............................................................ 376 Head injuries and litigants, seizures (Hyslop)........ 336 ST0852073 380 JOURNAL OF INDUSTRIAL HYGIENE AND TOXICOLOGY Health insurance, the industrial physician and-- Lackey, Robert W.: Observations on the acute retirement, group life and non-compensable and chronic toxidty of toxaphene in the dog.. disability insurance (Fitzhugh)....................... 277 Observations on the percutaneous absorption of H of workers exposed to galena (Belden and Garber).............................................................. 347 Heinz body formation in vivo, A property of hene in the rabbit and the dog............. S H. D. and Tracewell, T.: Penetration of air-borne particulates through the human -t methylene blue (Spicer and Thompson).......... 206 Hemmett, Gordon M.: Incidence of diabetes Lane, C. Guy: Cutaneous deansing for industrial ** mellitus among applicants for employment workers............................................................... jj* by an industrial plant...................................... 261 Lapp, R. E. and Andrews, H. L.: Nuclear Hemoglobin, effect of para-aminobenzoic add radiation physics............................................... on the in vivo oxidation of (Spicer)................ 204 Largent, Edward J. and Heyroth, Francis F.: * Henson, Edward V. see Saxton, Richard J. Hexanedlone-2,5, Assay of Acute Vapor Toxidty The absorption and excretion of fluorides. III. Further observations on the metabolism (Carpenter, C. P., et aL)................................... 343 of fluorides at high levels of intake......................jj, Heyroth, Francis F. tu Largent, Edward J. Lang, Edward P. su Luaky, Lehman M. see Treon, Joseph F. Lead arsenate, the hazards associated with the Hodge, Harold C,, Sterner, James H., use of, in apple orchards (Famer, Yaffe, Scott Maynard, Elliott A. and Thomas, Joan: and Adley)........................................................ ' Short-term toxidty tests of the mono and di compounds in human pleural fluid and blood methyl ethers of hydroquinone......................... 79 serum, solubility of (Hamid)........................... 327 see Thomas, Joan X. tungsten, vanadium, uranium, copper and Hogue, Warren L., and Mallatte, Frederick copper-arsenic poisoning, the effect of BAL S.: A study of workers exposed to talc and on experimental (Lusky, Braun, and Lang)... 301 other dusting compounds u the rubber in * LIdwell, O. M. su Bourdffion, R. B. dustry................................................................. 359 Litigants, seizures, head injuries and (Hyslop) ...236 Human problems in industrial machine design Lovelock, J. E. su Bourdillon, R. B. (Hatch).............................................................. 201 Lundgren, Kart-David and Swensson, Ake: * Hunter, Donald see Agate, John N. Occupational poisoning by alkyl mercury Hydrocarbons, aromatic, nutritional factors compounds......................................................... 190 affecting the toxidty of some, with special Lungs and circulation, a new method of evaluating reference to benzene and nitrobenzene com disability in silicosis and in other conditions pounds (Shils and Goldwater)......................... 175 of the (Pelnar)................................................ . 264 Hydroquinone, short-term toxidty tests on the Lusky, Lehman M,, Braun, Herbert A., and mono and di methyl ethers of (Hodge, Lang, Edward P.: The effect of BAL on Sterner, Maynard ana Thomas)..................... 79 experimental lead, tungsten, vanadium( ura N-Hydroxyethyl ethylene lmlne. Range-finding nium, copper and copper-arsenic poisoning... 301 toxidty data, List HI (Smyth, et aL).............. 60 N-Hydroxyethyl propylene diamine, op. di___ 60 * Hygiene (Manual of Public Health). Third Edition (Currie).......... ................................. 121 history of factory and mine (Teleky).................. 172 industrial and toxicology. Volume I. (Patty)... 121 Hyslop, George H.: Seizures, head injuries and litigants.............................................................. 336 MacFarlan, A. M. su Bourdillon, R. B. Machine design, industrial, human problems in (Hatch).............................................................. 201 Mallette, Frederick S. su Hogue, Warren L. Maloof, Clarence C.: Bums of the skin produced by trichloroethylene vapors at room tempera ture..................................................................... 295 Marble, Henry C. and Bishop, William A.: Industrial physician, the, and health insurance Intervertebral disc injury: an analysis of one --retirement, group life, and non-compensa hundred and thirteenindustrial cases............ 46 ble disability insurance (Fitzhugh).................. 277 Marsh, Arnold: Smoke: the problem of coal and the, and workmen's compensation--current the atmosphere.................................................. 64 trends in compensation legislation (Waters).. 251 Maximum allowable concentrations of atmos Intervertebral disc injury: an analysis of one pheric impurities (Drinker and Cook)........... 51 hundred and thirteen industrial cases (Marble Maynard, Elliott A. su Hodge, Harold C. and Bishop)...................................................... 46 McGilvray, William su Prlnd, Frank Introduction to Industrial Medicine (Hazlett)... 376 McOmie, W. A.: Comparative toxicity of mefha- Isopropanol, Assay of Acute Vapor Toxicity crylonitrile and acrylonitrile........................... 113 (Carpenter, C. P., et al.)................................... 343 Medical control of beryllium poisoning (Taber- Isopropenyl acetate, Range-finding toxidty data, shaw, Dustan and Goldwater)........................... 227 List III (Smyth, et aL)..................................... 60 Medicine, introduction to industrial (Hazlett).. 296 Isopropyl "Cellosolve", Assay of Acute Vapor the practice of industrial (Davies).................... 172 Toxidty (Carpenter, C. P., et al.)......................343 Mesityl oxide, Assay of Acute Vapor Toxicity (Carpenter, C. P., et al).................................. 343 Keenan, Clara su Treon, Joseph F. Metabolism of fluorides at high levels of intake, Kesel, Raymond su Thomas, Joan T. further observations on. III. The absorption Ketene, airborne, physiologic response of animals and excretion of fluorides (Largent and Hey exposed to (Treon, Sigmon, Kitzmiller, roth).................................................................... 134 Heyroth, Younker and Cholak)..................... 209 Meth&ciylaldehyde, Assay of Acute Vapor King, Barry Griffith: High concentration-short Toxicity (Carpenter, C. P., et al.).....................343 time exposures and toxidty............................. 365 Methacryl aldehyde, Range-finding toxicity Kitzmiller, Karl V. su Treon, Joseph F. data, List III (Smyth et al.)............................ 60 i'll fv V r l J INDEX TO TEXT AND BOOK REVIEWS ST 0852014 381 rlonltrlle, acrylonitrile, comparative ity ol (McOmie)........................................ 113 i acrolein. Assay of Acute Vapor Toxic{Carpenter, C. P., et al.)............................343 1 acrylate, op. cit.......................................... 343 1 amyl alcohol, op. cit................................ 343 L and ethyl acrylate, the toxicity of (Trcon, son, Wright and Kitzmiller)........................317 "Cellosolve", Assay of Acute Vapor ty (Carpenter, C. P., et aL).................. 343 ^elloeolve" Acetate, op. cit................... 343 dloxolane, Range-finding toxicity data, : HI (Smyth, et aL)..................................... 60 1-1,3-dloxolane. Assay of Acute Vapor dty (Carpenter, C. P., et al.)................. 343 , ethyl ketone, op. cit................................. 343 sfl morpholine. Range-finding toxicity , List III (Smyth, et aD........................... 60 -- blue, Heinz body formation in vivo, erty of (Spicer and Thompson)..........206 ripentanol-2, Assay of Acute Vapor iaty (Carpenter, C. P., et al.)................. 343 l vinyl ketone, op. cit................................ 343 , A. A. su Bourdlllon, R. B. 9, A. R. su von Oettlngen, W. F. methyl and di methyl ethers of hydroquinone, short-term toxidty tests of the ` je, Sterner, Maynard and Thomas)....... 79 Jrlanlllne, xylidine, the toxic properties of (Troon, Deichmann, Sigmon, Wright, Witherup, Heyroth, Kitzmiller and Keenan). 1 Aaopropanolamlne, Range-finding toxidty sta. List m (Smyth, et al.)........................... 60 fuller, Jan su Silverman, Leslie tn, Carl A. su Demehl, C. U. isidhardt, H. W. su Demehl, C. U. lose, human, penetration of air-borne parti- ' ml.twi through the (Landahl and Tracewell) 55 ifadear Radiation Physics (Lapp and An drews)..................... 172 )ccupatlonal marks and other physical signs: a guide to personal` identification (Ronchese) 64 " poisoning by alkyl mercury compounds (Lundgren and Swensson)........................................... 190 Oiathiane, Assay of Acute Vapor Toxidty (Car: penter, C. P., et al.)..........................................343 \V ^ Para-amlnobenzolc add, effect of, on the in vivo oxidation of hemoglobin (Spicer).................... 204 % *Patty, Frank A.: Industrial hygiene and toxiool11 ogy. Volume 1...................................................... 121 * Particulates, air-bome, penetration of, through the human nose (Landahl and Tracewell)___ 55 - Pelnif, Pfemysl: A new method of evaluating disability in silicosis and in other conditions ^ of the lungs and circulation.............................. 264 Percutaneous absorption of toxaphene in the rabbit and the dog, observations on the (Lackey)............................................................. 155 ky Pentanedlone-2,4, Assay of Acute Vapor Toxic ity (Carpenter, C.P., et al.)............................ 343 3-Pentene-2-one, op. cit......................................... 343 Perry, K. M. A. su Agate, John N. /Phelps, Earl B.: Public health engineering. Volume 1............................................................. 64 t Phenol, local and systemic effects following skin contact with. A review of the literature (Deichman)........................................................ 145 P * Phenoxy propylene oxide, Range-finding toxidty data, List HI (Smyth, et al)........................... 60 Physics, nudear radiation (Lapp and Andrews). 172 Physiologic response of exposed to air- bome ketene (Troon. Sigmon, Kitzmiller, Heyroth, Younker, and Cholak)..................... 209 animals to respiratory exposure to the vapors of diisopropylamine (Troon, Sigmon, Kitzmiller ' and Heyroth)...................................................... 142 animals to Trichloroacetonitrile administered orally, applied upon the skin or inhaled as a vapor in air (Troon, Sigmon, Wright and Kitzmiller)............................................................235 man to ammonia in low concentrations (Silver- man, Whittenbeiger and Muller)...................... 74 Pilot error (Davis).................................................. 65 Pleural fluid and blood serum, solubility of lead compounds in human (Harrold).......................327 Pneumoconiosis, benign, in a tin oxide recovery plant (Cutter, Faller, Stocklen and Wilson).. 139 from Fuller'searth: Reportofacasewithautopsy findings (Tonning).............................................. 41 (lung dust lesions) versus tuberculosis (Cole). 122 Pneumonitis, scute, in workers exposed to beryl lium oxide and beryllium metal (Aub and Grier).................................................................. 132 Poisoning, beryllium, medical control of (Taber- shaw, Dustan ana Goldwater)......................... 227 occupational, by alkyl mercury compounds (Lundgron and Swensson)................................ 190 Pozxanl, Urbano C., Well, Carrol S., and Carpenter, Charles P.: Subacute vapor toxicity and range-finding data for ethyl acrylate.............................................................. 311 su Carpenter, Charles P. Priiiei, Frank, Church, Franklin, and Me* Gllvray, William: An improved animal dusting apparatus.............................................. 106 1 -Propene-2-chloro-3-dIol-dlacetate, Assay of Acute Vapor Toxidty (Carpenter, C. P., etal.)................................................................... 343 1-Propene-l ,3-dlol dlacetate, of. cit................... 343 Range finding toxidty data, List IH (Smyth, et aL).................................................................. 60 l-Propene-3-diol dlacetate. Assay of Acute Vapor Toxidty (Carpenter, C. P., etal.)____343 Propyl "Cellosolve," op. cit.................................... 343 Propylene dlchlorlde, op. cit.................................. 343 Propylene fluorohydrln, op. cit............................. 343 Range-finding toxidty data, List HI (Smyth, etal.).................................................................. 60 Propylene glycol in the rat, range-finding toxic ity tests on (Thomas, Keitel and Hodge)........ 256 Propylene Imlne, Assay of Acute Vapor Toxidty (Carpenter. C. P., et al).................................... 343 Public Healtn engineering. Volume I(Phelps). 64 Range-finding data for ethyl acrylate, subacute vapor toxidty and (Pozzani, Weil and Car penter)................................................................. 311 toxidty data, list III (Smyth, Carpenter and Weil)................................................................... 60 toxidty tests on propylene glycol in the rat (Thomas, Kesel and; Hodge).............................. 256 Rather, Leland J. su Ambrose, Anthony M. Raymond, W. F. su Bourdlllon, R. B. RDX su Cydotrlmethylenetrinltramlne Respiratory exposure to the vapors of diisopropyl amine, the physiological response of animals to (Troon, Sigmon, Kitzmiller and Heyroth). 142 ST0852075 382 JOURNAL OF INDUSTRIAL HYGIENE AND TOXICOLOGY Richardson, T. D. su Agate, John N. Ronchese, Francesco, MJj.: Occupational marks and other physics! signs: a guide to personal identification...................................... 64 Rubber industry, the, a study of workers exposed to talc and other dusting compounds in (Hogue and Mellette).......................................... 359 Schuster, B. set Bourdlllon, S. B. Scott, K. su Femer, Lloyd M. Seizures, head injuries and litigants (Hyilop) 336 Sexton, Richard T. and Henson, Edward V.: Dermatological injuries by ethylene oxide... 297 Shila, Maurice B. and Goldwater, Leonard J.: Nutritional factors affecting the toxicity of some aromatic hydrocarbons with special reference to benzene and nitrobenzene com pounds............................................................... 175 Sigmon, Howard B. su Troon, Joseph F. Silica gel catalyst, experimental studies on the action of administered to guinea nin bv inhalation (Deraehl, Nan, Frank anaNdahardt)................................................................. 32 Silicon tetrachloride, Asaey of Acute Vapor Toxicity (Carpenter, C.P., et aL)....................343 Silicon tetrafluonde, op. til................................. 343 Sillcoals, a new method of evaluating disability in, and in other conditions of the lungs and circulation (Pelnif)....... ................................... 264 Silverman, Leslie, Whlttenberger, J. L. and Muller, Jan: Physiological response of man to ammonia in lowconcentrations................... 74 Skin contact with phenol, Vocal and systemic effects following. A review of the literature (Detehman)....................................................... 146 * handbook of diseases of tbe(Sutton)..................307 Smog, the problem in Los Angeles county. An interim report on smog research--"-June 2, 1947-June 2, 1948 (Stanford Research Insti tute).................................................................... 121 Smoke: the problem of coal and the atmosphere (Marsh).............................................................. 64 Smyth, Henry F. su Carpenter, Charles P. Smyth, Henry F,, Jr., Carpenter, Charles P., and Well, Carrol S.: Range-finding toxicity data, list HI...................................................... 60 Souiek, B. see Teislnger, J. Spicer, Samuel S.: Effect of para-aminobenzoic add on the in vivo oxidation of hemoglobin.. 204 and Thompson, B. C.: Heinz body formation in vivo, A property of methylene blue...........206 Stanford Research Institute: The smog prob lem in Los Angeles county. An interim report on smog research--June 2, 1947-June 2, 1948.................................................................. 121 Steadman, L. T. su Blsenbud, Merril Sterner, James H. see Hodge, Harold C. Stocklen, Joseph B. see Cutter, Harold C. Sulfoacetlc acid. Range-finding toxicity data, List HI (Smyth, et aL)..................................... 60 Sutton, Richard: Handbook of diseases of the skin..................................................................... 307 Swensson, Ake see Lundgren, Karl-David Tabershaw, Irving R., Duston, Cyril and Goldwater, Leonard J.: Medical control of beryl lium poisoning................................................... 227 Talc and other dusting compounds, a study of workers exposed to, in the rubber industry (Hogue ana Mallette)........................................ 359 Technical and scientific developments related to the asbestos industry in Germany (German Industry. Board of Trade)................................ 171 Teislnger, J. and Souiek, B.: Absorption and elimination of carbon disulfide in man....... Teleky, Ludwig: History of factoiy and hygiene........................................................... Tetracnloroethylene, Assay of Acute Vap Toxidty (Carpenter, C. P., et aL)............. 1,1,2,2-Tetrachloroethane, op. tit................ Tetrachloro tetrafiuoro propane (mixed iao. mon), op. til................................................ yg Tetraethoxy silane (ethyl silicate), Range-findixi k toxicity data, List IH (Smyth, et aL).. 7777* n Tetraethylene pentamine, op. tit..................... ` 2 Tetraethyl orthoallicate. Assay of Acute Vapor Toxiaty (Carpenter, C. P.. et al.)..................34. Thioaeetamlde in rats, toxicity of (Ambrose, - DeEds, and Rather)......................................... p-Thioxane, Assay of Acute Vapor Toxicity (Carpente^ C. r., et aL)....................................341 Thomas, J. C. see Bourdlllon, R. B. Thomas, Joan T., Head, Raymond, and Hodge, Harold C.: Range-finding toxidty teats on propylene glycol in the rat............... 256^ su Hodgt, Harold C. Thompson, B. C. su Spicer, Samuel S. Toluene, Assay of Acute Vapor Toxidty (Carpen ter, C. P., et al.)................................................. 343 o-Toluldlno ethanol (o-Tolyl ethanolamine), Range-finding toxidty data, List IH (Smyth, etaL).................................................................. 60 Tonnlng, Henrik O.: Pneumoconiosis from Fuller's earth: Report of a case with autopsy findings.............................................................. 41 Toxaphenein the rabbit and the dog, observations on the percutaneous absorption of (Lackey). 155 observations on the acute and chronic toxidty of in the dog I. (Lackey)....................................117 Toxidty and potential dangers of cyclotrimethyl ene-trinitramine (RDX) (von Oettingen, Donahue, Yagoda, Monaco and Harris)........ 21 comparative, of acrylonitrile and methacrylonitrile (McOmie)............................................ 113 data, range-finding, list HI (Smyth, Carpenter and Weil)........................................................... 60 high-concentration-short time exposures and (Xing)................................................................ 365 of some aromatic hydrocarbons with sped&I reference to benzene and nitrobenzene com pounds, nutritional factors affecting the (Shils and Goldwater)...................................... 175 of thioacetamide in rats (Ambrose, DeEds, and Rather).............................................................. 158 subacute vapor, and range-finding data for ethyl acrylate (Pozzani, Weil, and Carpenter)........311 tests on propylene glycol in the rat, range-finding (Thomas, Kesel and Hodge)............................ 256 the assay of acute vapor, and the grading and interpretation of results on 96 chemical com pounds (Carpenter, Smyth and Pozzani)....... 343 the, of methyl and ethyl acrylate (Treon, Sig mon, Wrignt and Kitzmiller)......................... 317 Toxicology, industrial hygiene and. Volume I. (Patty)............................................................... 121 Tracewell, T. su LandahL H. D. Treon, Joseph F,, Deichmann, William B., Sigmon, Howard B-, Wright, Howard, Wltherup, Sylvan O., Heyroth, Francis F,, Kitzmiller, Karl V., and Keenan, Clara: The toxic properties of Xylidine and Monoethylaniline.............................................. 1 Younker, Waldo J., and Cholak, Jacob: Physiologic response of animals exposed to airborne ketene................................................. 209 ,,fln Va i *V V ' ST0852076 INDEX TO TEXT AND BOOK REVIEWS 383 "Joseph F.: The physiological responie of hnali to respiratory exposure to the vapors pBisopropylamine......................................... 142 l.physiological response of animals to Trir oacetonitrile administered orally, applied i the akin or inhaled as a vapor in air___ 235 ridty of methyl and ethyl aoylate......... 317 aacetonitrile administered orally, ap- upon the skin or inhaled as a vapor in the physiological response of animals to Hieon. Sigmon, Wright, and Kitzmiller)___ 235 j.Trlcnloroethane, Assay of Acute Vapor Taxidty (Carpenter, C. P., et aL)....................343 thyleae, op.cit.................................... 343 at room temperature, burns of the skin duced by (Maloof)..................................... 295 roallane. Assay of Acute Vapor Toxicity {Carpenter, C. P.. et al)................................ 343 ?nffe-finding toxicity data, List HI (Smyth, jaL)............................................................... <S0 -Triethoxy propene-l, Assay of Acute (Tapor Toxicity (Carpenter, C. P.. etaL)___343 _thyl*M tetramlne, Range-finding toxicity [(data. List III (Smyth, et al).......................... 60 jS-Trimethytcydobexanol-1, op. dt.......... 60 jji|TritntliylnanaiiQiie, op.cit...................... 60 , hing dust lesions (pneumoconiosis) Jftytrsus (Cole).................................................... 122 vanadium, uranium, copper and copj,per-arsenic poisoning,' the effect of BAL on ; experimental lead (Lusky, Braun and Lang). 301 ilum, copper and copper-arsenic poisoning, Ithe effect of BAL on experimental lead, j tungsten, vanadium (Lusky, Braun and Lang)................................................................ 301 [asadlum, uranium, copper and copper-arsenic poisoning, the effect ot BAL on experimental lead, tungsten (Lusky. Braun andLang)____301 an Den Bade, M. see Bourdtllon, R. B. entilatlon and heating, basic prindples of (Bedford)................ 63 Vinyl acetate. Assay of Acute Vapor Toxicity (Carpenter, C. P., et al)................................. 343 Vinyl etnyl ether. Assay of Acute Vapor Toxiaty (Carpenter. C. P., et al.)................................. 343 Vlnylldene chloride, op. cil.................................. 343 Vlnylldenefluoride, op.cit................................... 343 Vinyl trlchlorosllane, op. cit................................ 343 Vivo, A property of methylene blue, Heinz body formation in (Spicer and Thompson)........... 206 oxidation of hemoglobin, effect of para-amino- benzoic add on the (Spicer)............................ 204 von Oettlngen, W. 7., Donahue, D. D,, Yagoda, H., Monaco, A. R., and Harris, M. R.: Toxiaty and potential dangers of Cyclotrimethylenetrinitramine (RDX).......... 21 Wants, R. C. see Elaenbud, Merril Waters, Theodore C.: The Industrial physician and workmen's compensation--current trends in compensation legislation.............................. 251 Well, Carrol S. tu Pozxanl, Urbano C. set Smyth, Henry F., Jr. *Welr, J. B. do V. see Agate, John N. Whltteaberger, J. L, set Silverman, Leslie Williams, R. Tecwyn: Detoxication mecha nisms................................................................. 172 Wilson, William L. see Cutter, Harold C. Witherup, Sylvan O. see Treon, Joseph F. Wolf, B. S. see Blaenbud, Merril Workmen's compensation, the industrial phy sician and--current treads in compensation legislation (Waters).......................................... 251 Workers, a study of, exposed to talc and other dusting compounds In the rubber industry (Hogue and Mellette)...................................... 359 Wright, Howard see Treon, Joseph F. XyUdine and Monoethylaniline, the toxic proper ties of (Treon, Deichmann, Sigmon, Wright, Witherup, Heyroth, Kitzmiller and Keenan).. 1 Yaffe, C. D. see Famer, Lloyd M. Yagoda, H. see von Oettlngen, W. F. Younker, Waldo J. see Treon, Joseph F.