Document bBrDGVELK50JBmxjyd9oRKzk1

April y, 1968 fir. Janes Arr.mtroAg iicicer Aluminum 4s Choinlcal Jo.-.pcny Trentwood Works ..pokene, Vmjhingtori 99213 Dear Hr. Arnotrong 1 Mr. Pogue of our Seattle office has asked me to forward toxicity and safe handling Information relative to our fireresistant hydraulic fluids, Pydraul 312 nnd Pydraul A-200. The oral toxiolty of Pydraul 312 chows an LDra to rota of GiiO0 mg/kg and it la claaeiflod aa practically non-toxic" from tho acute oral point of view. When applied to the skin undiluted and allowed to remain overnight, a barely percept!', lo redness occurred, giving 0 maximum score of 1.3/8.0, which was classed as a slight Irritant. The material proved capable of Leing absorbed through the sir In In high doses when allowed to remain on the rabbit under a cuff. The minimum lethal dose was somewhere over 5000 and under jioo mg/kg. This would fall into the slightly toxlo ' ranee. The material la a alight eya Irritant when applied undiluted to the rabbits' eyes and thore waa mild discomfort end slight redness. The maximum score wee 13/11) and the eye had returned to normal within three daya. fiats ourvlvod six-hour Inhalation exposure to the vapore evolved ;.t ambient temperatures following the passage of air through tho material. No systemic effects were noted. Animal toxiolty studies with Pydraul A-500 have Indicated that the oral lethal dooe (LD50) to rats is 10,590 milligrams per kilogram. Tlie lethal dose when the material was applied undiluted to the untroicen skin of rabbits la approximately 1550 milligrams per kilogram. The skin and eyo Irritation r.nd vapor Inhalation tests results wore comparable to the data for Pydroul 312. Mi'. Jar.ioa Armstrong -2- April 9, 1963 ,.e conclude from Uio above tfu>t accidental Ingestion on the part oi' humans 1.-. not a particular hazard In view of the high oral lethal dose In rats, Similarly, single massive ultln exposures should not be linnodlately hazardous. The lethal dose obtainod In skin penetration studies Is auoh, howover, that prolonged and repeated skin contact should be avoided because or possible systemic effects. In addition, prolonged and repeated skin uontaot may lead to skin Irritation. Vs also feel that vapor inhalation should be avoided when the fluid Is heatod to slevated temperatures. fluoh exposure again relates to prolonged or repeated exposures rather than short-term massive or acute exposures, in the cose of the latter, workmen would not voluntarily expose themselves to concentrations that ora hazardous because of Irritation of tho respiratory tract. I have enoloeed a copy of a sununary of our Interpretation of tho data for Fydraul 312. The Information applies similarly to Fydraul A-200. If Z con ba of any further help, please let me know. Sincerely, JUSKicJS CCi D. R. Pogue - Seattle BCC: N. T. Johnson Enclosure A. Smraet Kelly, M.C. Medical Director MONS 091179