Document bBLK9ojgnjw686z49XrZMGo6D
CONFIDENTIAL
World Register of Cases of
ANGIOSARCOMA OF THE LIVER (ASL)
due to VCM
REVIEW DATE
1st JANUARY 1989
*********
Collated by:
\
Dr Brian Bennett
Occupational Health
ICI Chemicals and Polymers Ltd
Hillhouse Site
PO Box 4
Thornton-Cleveleys
(Telephone
Blackpool FY5 400
(Telex
England
(Facsimile
0253 861632 J 67483ICIPLHG)
0253 861861 J
y
GENC 008324
fv_
LIVER ANGIOSARCOMA CASES CIRCULATION OF REGISTER
CONFIDENTIAL
FEBRUARY 1989
APPLETON B BAGSHAW Dr I M M BAND Dr P R BARON Dr C BARRAT Dr G BAXTER Dr Peter BAYLAC Dr BELLEC Dr BENECH Dr M BENNETT Dr B BERTAZZI Dr P BERTUZZI M BEYNON D W S' BISHOP Dr C BORRELLI F E BRAUN Dr C L J BREWER Dr M D BRYSON Dr D D BYREN Dr David CARTER Dr J T CATANZARITI A CELLA C CHANCE M CLARKE Dr E A CLAYTON H CONTASSOT Dr J C DAVIES J G DE JONG Dr G DELORME Dr F DEPLAN Dr F DIETZ Dr H W DOLL Prof Sir Richard DOMBROWSKI S L S DRUMWRIGHT Dr J R DUPONT G EMMINGER H ERNST Dr W EVANS Dr A E J FALK, Dr H FAVRE Dr
FIELDING Miss C FILLINGER J FINCHAM Ms Shirley FOA Prof V FORMAN Dr D FRASE R W FREIESLEBEN Dr W FRIEDEL Dr H P GAFFEY Dr W GOTTESMAN R T GROISMAN D HILLMAN Dr D W HOWARD Dr J K HUMPHRY Dr N F
ICI Runcorn, UK
Hydro Polymers Ltd, Newton Aycliffe, UK
Cancer Control Agency of British Columbia, Vancouver, Canada
ICI Runcorn, UK AECRP, Commentry, France
University of Cambridge, UK
Atochem, Chauny, France
Rhone Poulenc, Aubervillers, France
Naphtachimie, Lavera, France
ICI Hillhouse, UK
Inst of Occupational Health, Milan University, Italy
EVC, Brussels, Belgium
ICI Runcorn, UK
EMAS, Cardiff, UK
Georgia Gulf, Delaware City, USA
Akzo, Arnhem, The Netherlands
Imperial Oil, Sarnia, Ontario, Canada
ICI Wilton, UK Nobel Industrier, Sundsvall, Sweden
EMAS, London, UK
EVC, Brussels, Belgium
EVC, Brussels, Belgium
ICI Runcorn, UK Ontario Cancer Foundation, Toronto, Canada
Norsk Hydro, Newton Aycliffe, UK
Atochem, Saint-Fons, France
EVC, Brussels, Belgium
Shell, An Den Haag, Holland
Quebec, Canada Atochem, Jarrie, France
B F Goodrich, Akron, Ohio, USA
Imperial Cancer Research Fund, Oxford University, UK
Dow Chemical, Midland, Michigan, USA
Vista Chemical, Houston, Texas, USA
APME, Brussels, Belgium
VKE, Frankfurt, Germany Berufsgenossenschaft der Chemlschen Industries, Nurnberg, Germany
Lever Bros, Warrington, UK
Centres for Disease Control, Atlanta, Georgia, USA
Atochem, Montluel, France
ICI Millbank, London, UK
'
Solvay, Brussels, Belgium
Alberta Cancer Board, Edmonton, Canada
Inst Industrial Medicine, Milan, Italy
Imperial Cancer Research Fund, Oxford University, UK
DiversiTech General, Akron, Ohio, USA
ECVM, Brussels, Belgium Berufsgenossenschaft der Chemlschen Industries, Heidelberg, Germany
Monsanto Co, St Louis, Missouri, USA The Vinyl Institute, Wayne, NJ, USA
Electrochemical Industries, Acre, Israel
Diamond Shamrock Corp, Dallas, Texas, USA University of Otago School of Medicine, Wellington, New Zealand
ICI Australia, Melbourne, Australia
WPX/ASL - ASL ADDRESS,!
CORPOKAft SArEF(
FEB 9 1989
GENC 008325
*
JOHNSON Dr C A JOHNSON Roy N KAIPERT Dr J H KLEIN Dr H LAGAST Dr H LANHAM Dr John LANOU2IERE Dr Claudine LAWRENCE-JONES Sir C LEE Dr F I LELBACH Prof Dr WK LEVEQUE Dr G LEVISON Prof Dr D A LEWIS Dr P LIGO Dr R N LO MARTIRE Prof N LUSS R D LUSSATO Dr Josette MALTONI Prof C MATTIUSSI Dr R MELTON B MIDDLETON D MOKKA Mr MONTESANO Dr R MOTTI Dr A A MUNOZ MOUTON Dr M MacSWEEN Prof RNM NAKAMURA Dr S OSMAN Dr J PADDLE Dr G M PAGLIALUNGA Dr S PAQUET Dr Christiane PATERSON Dr J C FIRASTU Dr Roberta POSSBERG Dr J PUECH Dr A M PURDHAM Dr J RAMBAUD Dr J RICHARD Dr A ROBSON Mrs D RODRIGUES Dr MJF RUTY Dr J
SALG Dr Joyce A SCHIPPER Dr H SCHUCKMANN Dr F SERONNE Dr D SHAH Dr Has SIGRIST Dr J SIMONATO Dr L SMITH Prof Allan H SMITH J S SMITH Dr P M SPIRTAS Dr R STAFFORD Dr J STAHNECKER Dr E SULAIMAN Dr
2- -
Goodyear Tire & Rubber, Akron, Ohio, USA GenCorp, Fairlawn, Ohio, USA Dow Chemical Europe, Horgen, Switzerland Dynamit Nobel, Troisdorf, Germany Solvay, Brussels, Belgium Dow Chemical, Midland, Michigan, USA Solvay, Tavaux, France Chief Medical Officer, ICI, London, UK Victoria Hospital, Blackpool, Lancs, UK University of Bonn, West Germany CDF Chimie, AZF, Bully-les-Mines, France Guy's Hospital, London, UK Chemical Industries Association, London, UK Dupont, Wilmington, Delaware, USA EniChem, Milan, Italy Occidental Chemical, Pottstown, Pennsylvania, USA Atochem, Port de Bouc, France Institute di Oncologia, Bologna, Italy Montedison, Milan, Italy Formosa Plastics, Delaware City, USA Hydro Polymers Ltd, Newton Aycliffe, UK Neste Oy, Espoo, Finland IARC, Lyon, France Duperial SAIC, Buenos Aires, Argentina Rio Rodano, Madrid, Spain Western Infirmary, Glasgow, Scotland Japanese PVC Association, Tokyo Health & Safety Executive, Bootle, UK ICI Central Medical Group, Alderley Park, UK Montedison, Novara, Italy Atochem, Serquigny, France ICI Runcorn, UK Istituto Superiore di Sanita, Rome, Italy Wacker-Chemie, Munich, Germany Atochem, Brignoud, France University of Toronto, Ontario, Canada RP Recherches, Antony, France Rhone Poulenc, Roussillon, France Saskatchewan Cancer Foundation, Regina, Canada ICI, Sao Paulo, Brazil Atochem, St Auban, France NIOSH, Cincinnati, Ohio, USA University of Manitoba, Winnipeg, Canada Hoechst, Frankfurt, Germany Diamond Shamrock, Dallas, USA CMA, Washington DC, USA
Shell Chimie, Berre L'Etang, France IARC, Lyon, France University of California, Berkeley, USA ICI Hillhouse, UK Llandough Hospital, Penarth, UK NCI/NIH, Bethesda, Maryland, USA Somerset, UK BASF, Ludwigshafen, Germany Arabian Petrochemical Co, Saudi Arabia
WPX/ASL - ASL ADDRESS,2
GEMC 008326
-3-
TACHECI Dr H TAMBURRO Prof CH ten BERGE Dr W F TENKHOFF Dr N TEPPER Dr L B TERWIESCH Dr B THERIAULT Dr Gilles THIIS-EVENSEN Dr E THOMSON Dr D H TONER H P VAN DER MERWE Dr H J WALLACE J R WALTEMATE H
WEJDLING S 0 WILLIAMS Dr DMJ WILSON Prof R YORK J YOUNG A E ZOBER Dr M A
Hoechst AG, Frankfurt, Germany University of Louisville, Kentucky, USA DSM, Geleen, The Netherlands Huls AG, Marl, Germany Air Products, Allentown, Pennsylvania, USA Huls AG, Marl, Germany McGill University, Montreal, Canada Norsk Hydro, Porsgrunn, Norway Cancer Treatment & Research Foundation, Halifax, NS, Canada Society of the Plastics Industry, Washington DC, USA AECI, Sasolburg, South Africa Esso, Sarnia, Ontario, Canada BF Goodrich, Cleveland, Ohio, USA Norsk Hydro, Stenungsund, Sweden BP Chemicals International, Barry, UK Harvard University, Cambridge, Massachusetts, USA
EVC, Brussels, Belgium EVC, Brussels, Belgium BASF, Ludwigshafen, Germany
From: Dr B Bennett, Occupational Health Department, ICI Chemicals & Polymers., Hillhouse Site, PO Box 4, Thornton-Cleveleys, Blackpool FY5 4QD, England
WPX/ASL - ASL ADDRESS,3
GENC 008327
TTo nfidential
REGISTER OF CASES OF ANGIOSARCOMA OF THE LIVER DUE TO EXPOSURE TO VINYL CHLORIDE - REVIEW DATE 1 JANUARY 1989
PREFACE : ACKNOWLEDGMENTS, SIGNIFICANT CHANGES, COMMENTS AND REQUESTS
1 The 7 new cases in the Register are the following: Canada 13; France 23, 24 and 25; Italy 07; UK 15 and 16.
2 There are amendments from the previous Register against the following cases: Canada 11 and 12, UK 14 and US 4l.
3 I would like to thank the following for information about new cases: Dr Dietz, Dr Contassot, Dr Lagast,Dr Benetta, Dr Williams, Dr Smith, Dr Lee.
4 For additional information about other cases I thank also Dr Delorme, Monsieur Bibeau, Dr C A Johnson, Mr Roy N Johnson and Professor Lelbach.
5 So far as I know the following people are still alive: cases France 15, 22, 23 and 24; Germany 31 and 32; US 33 and 36. Is this correct? This is important information for the industry world-wide and I would appreciate news, especially regarding the cases in Germany, please.
6 Tables 4g and 4H have been enlarged by the addition of the factories at Tavaux (France) and Hillhouse (UK), as each of these has now had 4 cases.
7 I should be glad if all recipients of this Register would continue to keep me fully informed of any new cases, or give the name and address of someone who can send me the necessary details. I have again attached a blank sheet at the back of the Register so that information can be supplied under the appropriate headings, so far as possible. Please also send any other relevant information about earlier cases, or about factory changes.
8 RESEARCH: (a) May I again ask that all individuals involved in relevant research keep me informed and if possible send me reports. Perhaps recipients of this Register would pass on my request.
(b) Co-factors - I have recently met Professor Carlo Tamburro at the University of Louisville, USA, to assess the data which many of you kindly sent in response to my questionnaire about possible co-factors with Vinyl Chloride. We found there was no correlation within Europe but among the North American cases there was a suggestion of a co-factor effect on latency. In plants where Di-Ethyl Maleate had been used, the latency period seemed to have been shortened.
9 There was an excellent response to the circular I sent in June 1988 about the Register mailing list. Thank you. Please continue to keep me up to date with news of retirements, movements and changes of address.
FROM:
Dr Brian Bennett, Occupational Health, ICI Chemicals 6 Polymers Limited Hillhouse Site, P 0 Box 4, Thornton-Cleveleys, Blackpool, FY5 ^D, England
February 1989 BB/BGS
Index
Table Sequence
Belgium
Canada
Czechoslovakia
France
Germany
Italy
Japan
Norway
Sweden
UK
USA
Yugoslavia
Incidence of Cases per annum (Table i)
Distribution of Cases
by Country
(Table 2)
Pattern of Cases by
Factory
(Table 3)
Latency Periods (Table 4A)
Distribution of Latency Periods (Tables 4B-4H)
Annual Geographical Incidence (Table 5)
ICI CALS & POLYMERS
WPX/ASO - LANG
LIVER ANGIOSARCOMA CASES (REVIEW DATE - 1 JANUARY 1989)
Page
1
1
1 1
1 ! ASL Case Numbers by year of Death
1 (Table 6)
2-3 1
1 ASL Case Numbers by year of first exposure
41
(Table 7)
1
5-9 1 Western Europe PVC Producers - Start-up Dates vs ASL Cases
1 (Table 8)
10-15
1
1 USA PVC Producers - Start-up Dates vs ASL Cases
16-17
i
(Table 9)
1
18 1 Canadian PVC Producers - Start-up Dates vs ASL Cases
1 (Table 10)
19 1
1 East European PVC Producers - Start-up Dates vs ASL Cases
20 1 1
(Table 11)
21-24 ! Japanese PVC Producers - Start-up Dates vs ASL Cases
1 (Table 12)
25-32
1
1 South & Central American PVC Producers - Start-Up Dates
33 I
(Table 13)
l 34 1 Australasian PVC Producers - Start-up Dates
1 (Table 14)
1 35 1 Middle Eastern PVC Producers - Start-up Dates
1 (Table 15)
1 36 1 Blank form for notifying new cases
1
1
37 1
38-44
1 1
1
1 45 1
1
i
ES, 4
.
Page 46 47 48-49 50-51 52 53 54 55 56 57
-
f*
Page I BELCIUM
COUNTRY AND REFERENCE HO
SAKE OR INITIALS
DATE OF BIRTH
01 } 12.01.11 l Solvay
129 09 40 1 Solvay
1CI CflbHfLALS A POLYMERS LIVER Angiosarcona Cases - (Review Dace : t January 1989)
VPX/ASL - LANC10CASES,6_
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
Jeaeppe I 00.07*58 | 00*05*76
Jeaeppe 1 20 OB 62 | 00*10.79
8 ACE AT DIAGNOSIS
39
YEARS OF EXPOSURE TO
DIAGNOSIS
10 11
YEARS OF EXPOSURE
DATE OF DEATH
129*06.76
HlSTOLOClCAL CONFIRMATION
11
13 1
14 |
15
1
>6
11
1
1 ESTIMATED |
1 |
EXPOSURE | OCCUPATION |
OTHER CAREER
l | OTHER
| COMMENTS
LEVEL |
1 HIGHLIGHTS 1
11
1
1I
1
11
l
High
11
1
lAutocleaner IDrlller In a |Hepatic tests
114 yra
(foundry
(in Oct 1974
1958-1968 t
|(2 yr)
exposed toj Polyworker | Farmer
[were normal. |Retired
200 ppa I 3 yr
l<15 yr)
|Feb 1975
for 6 hra |
|Vork in glass |Hospitaliaed
per day 1
find. 4 chemi- {May 1976
and |
|cal industry 1
certainly |
under
}
500 ppa I
In 6 to I
9a3 I
autoclaveal
1968-1972 (
exposed to|
50-200 ppa)
8 hra per \
day In
|
25.5
|
autoclaveal
1 1 1 ) 1 1 i 1 1 1 l 1 1
I Complete iCllnicsl and Icareer detal la (are given in a (paper by IHublet et al |in Arch. Belg. {Med. Soc., |Hyg. Med. (Trav. Hed. |Leg. |1977 pages 1601-622
1972-HH 1
i
1
exposed to|
1
1
50-200 ppa|
t
1
in auto- 1
1
t
clave room}
l
1
1974-100 I
1
(
PP" t
1
1
1975- 50 |
i
1
PP 1
l
1
RETIRED S
l
1
\ Feb 19751
l
l
li
1
11 08.62-03. |Autocleaner | Fireman since | 1st s Ign July
63 01.67 |5 yrs 5 laths 110 71.
|79: Thoracic
-10.71 * {Operator
|
Ipaln 07.79.
200 ppm Bh/day 04.63-12. 66 * 200 ppm
I 3 yrs 9nths.| |1 |1 t1 |1 11 11 1f 11 i1
\I \1
(Hepatic tests (altered 10.79 | PositIve (echography 111.79. HepaItectomy 02.80 iCIiemot her . | Inf ormat Lon Igiven in |]et te r J 2 Nnv
j1984 1 rom Hi (He Slrwivci.
1%, GENC 008330
5
FRANCE Shee t J
I Cl CHEMICALS & POLYMERS LIVER Angiosarcoma Casey - (Review Date; I Jan 89)
WPX/ASL - LANGIOCASESJO
J
L
12
131
1
1 COUNTRY AND \ NAME OX ) DATE OF 1
REFERENCE | INITIALS | BIRTH
NO
FRANCE
1
4 COMPANY
l J5
1 1 J | FACTORY
1 1 1 1
01 |H 02 | S IN 03 | NAV 04 (HOSE 05 |B
|15.04.24 RP i i
{03.06,1J PCUK
{06.02.20 RP i i
127.01.27 i PCUK i
129.01.38 PCUK
1
j RousaI lllon
1 1 J r 1 |Brlgnoud
t 1 1 r 1 1 1 1 |St Fona
1 i 1 1 1 1 1 |Brlgnoud
1 i i 2 l 1 1 1 | Br ignood
J 1 1 1 i 1 1 1 S 1 1 1 1
6 FIRST VC EXPOSURE 00.01.46 06.07.59
00.00,46
19.10.49
18.01.65
7 DATE OF DIACNOSLS 18.02.67 15.01.75
15.02.75
16.01.76
13.05.76
8 9 10 1 11
ACE AT DIAGNOSIS
YEARS OP EXPOSURE TO
DIAGNOSIS
YEARS OP | DATE OF EXPOSURE 1 DEATH
43 21 J 19 |19.02.67
63 16 12 124.01.75
55 29 29 129.06.75 49 26 26 104.01.76
38 11 J J 113.05,76 {
i
12 HISTOLOCICAL CONFIRMATION
Yes
Yea (NIOSH no
coaaent)
Yes
Yes
Yea
! 14 13 1
}
1
estimated 1
1
EXPOSURE | OCCUPATION 1
LEVEL 1
I
15
OTHtS CAREER HIGHLIGHTS
f
{ |
16
OTHER COMMENTS
J J
f
High High
{Autoclave {worker and |cleaner {19 yrs
i i t |2 yrs on laonoaer |10 yrs on Ipolyaerflsatlon |
f 1
1 | 1 |
|
* |Italian lorlgin 1 1 | 1
1
|Ref, Ravier ei {al Arch. Ha 1. 1 Prof. 1 30 n' 1 3 Nov 7 5 Ip 171-177
Ref. |C Bonneton et jal "Nouvelle |presse faedlcale" 15 Nov 1977 Jp 735 1
High High High
|Polyworker 1VCH production|Ref * Rety et
110 yrs as 116 yrs
{al Arch. Ha 1.
{autoclave 1 Italian POW {Prof. 1 37 n'
{cleaner
{Shepherd.
{6 June 7?
(Compounding | Sawyer, Ha a on Ip 551-555
|3 yra
1
t
1 |Monoaer
1
(production |
{worker
l
18 yrs PVC {flit ration
1
1 |
)18 yrs
11
1{ | Po lyworker ll)Thocacoto*y |Ref. P Coudere
1JI yrs
|9th Feb 1976 {et al "Sematne
1
{costal
{des hosplLaux
I {angiosarcoma | 10 Septembre
1 |2)Scfntlgraphy | 1976
|
|found A5L
{Previously had
I | 3)Haetorrhage Jbone
l
| f roa ASL
{angiosarcoma"
|
|4)Rlghc
| Also
1 {Hepatectony {Pill cliowskl et
||
|al "La Nouve 1 It?
|r i
Ii
{ Presse Med 1 t a ! t? l?th July I'm |Pdge 2485
Page 6
FRANCE Sheet 2
COUNTRY AND REFERENCE NO
NAME OR INITIALS
DATE OF BIRTH
06 | 14.04,34 l PCUK
126.04.27 | RP OB 101.04.34 | Solvay 09 100 *10*14 | RP
1CI CHEMICALS A POLYMERS LIVER Angiosarcoma Cases - (Review Date: l Jan 1909)
WPXMSL - LANG IOCASKS , I I
FACTORY
FIRST VC EXPOSURE
(Brlgnoud |01.03*58
(St Auban | 01.07.50 23.05.57 10.01.46
7 DATE OF DIAGNOSIS
12.08*76
After death HIOSH aaya 00*07.76 03*12.75
26.04.76
t 8 1 9 1 io
12
1
1
AGE At i YEARS OF | YEARS OF | DATE OF
DIAGNOSIS | EXPOSURE TO l EXPOSURE | DEATH
| DIAGNOSIS
1
HISTOLOGICAL CONFIRMATION
1
1
1
42 1
18
1 i n 1li.09,76
|(HIOSH
Yea
Jaaya
112.09.76)
1
1
1
1
t
i
49 1 26
t
1
| 22 102.07.76
Yes
1 (NIOSH no
1 ccwent)
1
1
42 l 19
1 1 I 19 130.01,77
Yes
l
1
1 I
1
1
63 i 28
t l 28 itS.12.77
Yes
1
1
1
1
1
1
1
1
1
I
1
1
1
1
1
t
1
1 1
1 n 1 14 I (5 1 36
ESTIMATED
|
EXPOSURE i OCCUPATION |
LEVEL
|
OTHER CAREER HIGHLIGHTS
i 1 | |
i
OTHER COMMENTS
1
1
1
Moderate
1(1958-1960) 12 yr. | filtration
1 |Thls man ha |A0L prior t
|AS. Ann. de
110--11 yra |polyworker
(Hal. Prof. IJuly *77
land works |lab7
|p 645 6 6. |AQL was fou
| in 1971 fiv
lyre before
| ASL
______________
High
(Plant fore- 11972-6 adaln
|aan In
(section In
(polymer-
|St Auban
1 1 (Died of tsept Icaerois | Small 11 vet
11 nation
1 lesion four
(after autoc
11 Moderate |6 yra packerl
1
1 IHad been
(6 autoclave |c lnr 114 yrs (autoclave |worker
(tunnel wort |previously
1 1 1 1
Very High |Polymer-
|10 yrs In
1 (Operated 4
1948-1966 Leaser Exposure 1966-1976
1laatlon
laulphurlc
loperator, lacld factory.
(autocleaner, (storekeeper 6
lautoclave Igeneral
(maintenance J services
(for renova Itunour fro (liver and (died after |second
j surglca1
foperat ion Ibtlto
Ibronchlai
|f1stula | Pa per by
[Dr Rety ei
|ln Archive |Ha lades
| Profess 1 oct |Vol 40 No
JI979 pages
[741-j.
1
'awduai
Wit1 iia'NHi
....... .
*
6EHC 008335
Page 7
FRANCE Sheet 3
JC1 CHEMICALS & LIVER Angiosarcoma Cases - (Review Date: 1 Jan 1989)
VPX/ASL -
iASES,12
12 n 14
16
COUNTRY AND REFERENCE NO
NAME OR INITIALS
DATE OF BIRTH
FACTORY
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
AGE AT, DIAGNOSIS
YEARS OF EXPOSURE TO
DIAGNOSIS
YEARS OF EXPOSURE
DATE OF DEATH
HISTOLOGICAL CONFIRMATION
ESTIMATED EXPOSURE
LEVEL
OCCUPATION
OTHER CAREER HIGHLIGHTS
|
|
\
I I
OTHER COMMENTS
24.05,19 15.02.12
00.12.56 10.01.78
58
St Fons
00.01.41 12.08.Y8~
21 37
10.01.78 31 13.11.78
High High
Autoclave cleaner
LO yrs In mechanical engineering
industry 1946-1956
1941-1946 polymer isation general purpose worker 1946-19*2 VCH synthesis (HC1 6 Acetylene) Foreman (agent de maltrlse)
im-----------
retired
IDled of (pulmonary )embolism 5
Idays after (surgery
I ___ _
13 1 ( |
1
16.08.14 PCUK
Brlgnoud 09.02.49 00.05.79
65
30
119.0) 31 | Solvay
(Tavaux [ 23.09.63 { 26.06.74
40 1
16
|l
l
i
l
f
||
1
i
1
|
|1
r
i
(
|1
i
i
|
|1
i
i
(
1\
i
i
[i
(
\i
t
|t
i
j
1
i1
11
i
i
1
05-04-24
St Fons
1943
Chimle
(Formerly
RP)
27 23,06.79
1 13 122.08 )9 1
i l1 t t1 1 i( ) if 1 l( 11 l i| I i|
1 lI 1 l1
Yea
High
Monomer productlon and polymer* isatIon
1 1AutocLeaner |2 yrs as eyele (Cigarette
i
|2 yrs.
lmechanic.
1 smoker until
1
|Auto-
|10 yrs as
11974. Ill all
1
loperator
lenameller In |of 1977 due tu
1
|9 yrs .
Isanltary ware lOesophagea1
1 1 Copolymers (manufacture (varices.
1
| 4 yrs
1
| Surgical
11
1
11ntervene Ion
11
1
(25.05.79
11
I
((right
11
1
Ihepatectomy)
1943-1975 ALJ types of ma Intenance
and
Jobs on
work
Internal 11- manufacture
ent 1 y
& nalntenanc
1975-1979 in VCM Poly
| Process
SENC 008336
Page
FFIANCE Sheet 4
ICI CHtHICALS & LIVER Angiosarcoma Cases - (Review Dace: l Jan 1989)
WPX/ASL - LANCIOCASRS, L3
14 15
16
COUNTRY AND REFERENCE NO
NAME OR INITIALS
DATE OF BIRTH
COMPANY
France
03*01.37
Chloe Chlmle (formerly
RP)
FIRST VC EXPOSURE
DATE OP DIAGNOSIS
ACE AT DIAGNOSIS
YEARS OF YEARS OF EXPOSURE TO EXPOSURE
DIAGNOSIS
DATE OP DEATH
HISTOLOGICAt CONFIRMATION
ESTIMATED J
EXPOSURE ) OCCUPATION LEVEL J
___ ____ J
07*07.55 28.09*82
45
27
High-20 yr Moderate 7 yrs
t
|Autoclave |cleaner I 1955-1962 | autoclave loperator
* 1962-1982
OTHER CAREER HIGHLIGHTS
OTHER COMMENTS
Left Hepatectony 1983
J C Contassot Letters of 5 10 1983 and 29 7 88.
t 16 1CIH
1 1 1 1 1
1i 113,07 22 | Chloe
t |SC Fon.
1
I Chimle
|
* | (Formerly I
1
1 RP)
1
11
1
11
(
11 1 17.10.41 1 05.01.83 11 li 1i J1 t1
1 1 i 1 1 1 1
61
1 1 41 1 1 1
1
1l 1 38 103.04.83
t1 11 11 11 11
11
t
Yes |Hlgh-33 yrsjPolyerisat-|
|Moderate- lion Process |
]Low - 5 yrs|Han
J
11
t
| |Maintenance |
1
(Worker
|
1 J Retired
|Jan 1979. |J C Contassot |Letters of 15 10 1983 and |25 7 84.
1 1
1- 1 17 |NAR
1 i 1 1 1 1 1 1 1
t1
1
11
1
11
1
11 |22 02.23 | Chloe
f | St Forts
i
f Chlmle
i
l l (Formerly I
1
1 RP)
1
11
1
11
1
11
1
i1
1
11
1
11
1
11
i
11
1
J 1 J___
t1
1
1 17.06.46 | 03.04.83 1
j1
1
ii
1
11
1
11
11
1
11
11
11
1
60
14.07*42 Solvay
09.09.63 21.03.84
42
1 1 1 t 1 34 1 i
1
21
1i
11
1 1___________
I*
I
1 28 |03 04.83 |
11
1
1i
1
1i
I1
1
11
1
11
1
11
1
11
11
1
27.12,84
1
1 Health &
1
t ISafety Agent|
$ 1
11
1
1
11
1
J
Yes
fHigh -
|Autoclave lOther sectors |Retired
123 yr.
fCleaner
|of St Fons
101*01*79
1 11948-1971 |Factory 1971- |J C Contassot
1|
11978
|Letter of
11
I
|S 10 1983
1(
f
i
1 lI
t1
1
I
1 1i
1 11
21*03,84 HLgh-J 2 yra|Autoclave Low - 9 yrs|Cleaner
09.03.84 Right Hepatectomy 05.05.8424.09.84 chemotherapy for lungmetastasis ;
art tai remission. 08.84 - 1 iver recurrence. 10.84 - lung: evolutlon of the disease
- 1,.IT,.-
"Ti"lfflMWrHWji
6ENC 008337
Page 9a
FRANCE^ Sheet 5
iLl UlbHI^^S 6 PULYMEKb
LIVER Angiosarcoma Cases
Dace: 1 Jan 1989)
JO
12 13
15
COUNTRY AND REFERENCE NO
NAME OR INITIALS
DATE OF BIRTH
19 15.J2.32
02,03.23
0J.JO.4O
22 I AL 113.08.28 | Atochem
( 11
J 11
1 1t
1 11
1 23
i ______ _ i 07.02.27
24 i DO 108.12 26 | Atochem
1 11
1 11
1 11
1 11
1 11
( 25
11 02.03.30 Solvay
FIRST VC EXPOSURE
DATE OP DIAGNOSIS
AGE AT DIAGNOSIS
Brlgnoud 07.04,59
52
Brignoud
f
195J
27.J2.85
SEP Hontlucon
1959
03.06.86
45
| St Auban l 01.09.58 ( 05.11.87 1
11
J
1
11
1
1
1t
1
1
1J
1
1
1 i ,!
J_
1944
1988
59 63
i
) Brlgnoud
i 1 1 1 1 1
1 1 1 1 1 1 1
1943 1962
1988
62
i
i
1988
58
YEARS OF EXPOSURE TO
DIAGNOSIS
34
27
29 1 1 1 1 1
44 i
45 J 1 1 1 1 1 1
26
YEARS OF EXPOSURE
DATE OF DEATH
HISTOLOGICAL CONFIRMATION
ESTIMATED EXPOSURE
LEVEL
OCCUPATION
OTHER CAREER HIGHLIGHTS
OTHER COMMENTS
25 22 26.L2.85
28.06:86
26 |Alive 1 1J 1i 1i 1i
Yes
i _j___
35 JAlive J
11 11 11 11 1J it 23 07.05.88
Yea
\
|Hyocardlal
AutocIave
I infarction
operator and
| 1980.Corona n
High
cleaner
Ibypass 1981.
{Letter from
I Dr Contassot
J 5.4,88________
j Portal
High
Autoclave
other parts 1 f ibros Is f:oi
operator and
factory
| 26.04.74. Tl
cleaner
nee 1946
(Illness was
(diagnosed at.
(presumably
|work related
(on 20.04.74.
{Letter from
|Dr Contassot
(05.04.86
High
Autoe leaner aintenance IHepatlc test
4 years
arker
|May 84 normal
IHepatlc test
|Hay 86 showee
(abnona 1 it ies
|Letter from
| Dr Bar rat
| t8.07.B6.
1 High
| 12 years
|
ILetters from
J 1958-70 |Autoclave J
|Dr Contassot,
t
| worker.
|
1 Low
1
(
| 1970-84 J J4 years In t
|Atochem f2.12.87 and |29 7 88.
i JControl Roonl High
1
Cleaner 6
| transplant
all PVC
| May 1988.
production
| InformatIon 1
jobs
I Dr J C Conta;
| Atochem, I98f
High JPVC Production
|Partiai
|- 2 years |
|Hepatectomy,
|HCV Detection |- 3 years |
(88, Chemothur
f(Information
1 |PVC Production (maintenance |
|Dr Contassot,
J Atochem . 1 98f
t |- 30 years (
1
High)
12 years) Lou )
- 5 years Polyfloor - 6 years Control Room - 12 years
|Tumnr Metasla I Lung, brain, |bone, spleen, | kidney.
|J nfnrmjt
| Dr II Lag, bt ,
| Solvay, f Novcmlv1 r
QEMC 08338
FRANCE Sheet 5
LIVER Angi osar com Cases
w Date
Jan 1989)
J COUNTRY AND
REFERENCE NO
FRANCE 19
20
t 21
22
23
24
25
2 |31
| 1 NAME OR | DATE OF INITIALS | BIRTH i t ii
4 COMPANY
1
MAZ |IS.12.32 Atochea
i
BA 102.03.23 Atochea
i i
Pa |01.10*40 RP
i ii AL |13.08.28 i Atochea
i
HA 107.02.27 Atochea
DO |08.12.26 Atochea
BB | 02*03.30 1 Solvay
1
1
i i i
15
1 1 1 [ FACTORY
1
! i 1 1 [Brlgnoud
1 1
i I \ Brlgnoud
1 1 1 i t 1 1 1
i | SEP |Hont Iticonj
1 i 1 1 1 1 I St Auban
1 1 1 1
i I St Fona
r i i i f |Brlgnoud
1 1 1 1 1 1 ITavaux
1 1 i i 1 1 i i
6 PIRST VC EXPOSURE
07,04,59
1951
1959
01.09.58
F5T5
1943
1
t |
1962
1
I
1 i ] i
7 DATE OF DIAGNOSIS
26.10.84 i
27,12.85
i 03.06.86
i i
i 05.11.87 t
i
1988
i
1988 L988
i l l i i i i l t l i I I i I i i I I
81
ACE AT DIAGNOSIS
52
63
i 45
i
i 59
i 63 1
1 1 1
J
1 62 1
1 1 1 1 1 1 58 1 1 i 1 1 1 1 1 i i
9 YEARS OF EXPOSURE TO DIAGNOSIS
25
34
i 27
i 29
i 44
45
26
10 1 it 1
YEARS OF | DATE OF EXPOSURE l DEATH
25 106.11.85 22 [26.12.85
4 128.06.86
26 |Alive 28 | Alive 35 1 Alive
23 I07.0S.B8
12 HISTOLOGICAL CONFIRMATION
Yea Yea
Yes
Yes Yes Yes
Yes
13 | 14
15 1
16
t1
1 ESTIMATED |
1 | OTHER
t ( OTHER
EXPOSURE | OCCUPATION 1
CAREER
| COMMENTS
LEVEL
|
1 i |An toe lave
| HIGHLIGHTS
1 i |
|
IKyocardlal |Infarction
(operator and|
J1980.Coronary
High | cleaner
|
Ibypass 1981.
High
[ i
i 1 lAutoclave
1 | Letter from
i |Dr Contassot
i 15.4.86 l J Port al [In other parts|flbrosIs from
(operator and|of factory
126.04.74. The
leleaner
[since 1946
| illoess was
High
1l 11 1t ii ri ii it JAutocleaner (Maintenance
Idlagnosed as |presumably |work related |on 20.04.74. JLetter from fDr Contassot 105.04.86 JHepstlc test
|4 years
|worker
{Kay 84 normal.
11
(Hepatic test
High
1 1 1 l i 112 years
1 l 1 i I |
|Hay 86 showed labnoma! 11 tes . |Letter from (Dr Bar rat 118.07.86. ILetters from
1958-70 (Autoclave |
|Dr Contassot,
1 worker.
|
| At ocher*
Low 1
1
1970-84 | 14 years In |
12.12.87 and |29 7 88.
High
|Control Roomf lAutoclave J
f |Liver
|Cleaner & |
11 ranaplant
lall PVC
j
{May 1988.
(production |
jInformat ion f r<
| jobs
|
|Dr J C Cent ay Si
High
11 |PVC Production
lAtochem, 1988 |Partial
1- 2 years
| Hepatectorey , Af
tHCV Detection
|88, Cheraothera;
l- 3 years [
| Informat ion fn
1PVC Production
|Dr Contassot ,
(maintenance f
lAtochem, 1988
1- 30 years 11 years) | Polycleaner
1 |Primary Liver
High) |- 5 years
|Tumor Ketastase
| Poly Moor |- 6 years
| 1 ling, bral n ,
Ibone, spleen.
12 years) Low )
{Control Room] t- 12 years
1
ii ti (|
[kidney.
f j [nformat i mi tru |Dr H Lagjst, |SoIvay, | Novcrrtlw | SHHH
.1 iV.i.
008337u~. -
.....................
bhNL
--*
Page
CERKANY Sheet 1
IC1 CHEMICALS & POLYMERS LIVER Angiosarcoma Cases - (Review Date: I Jan 1989)
UPX/ASL - LANGiUCASES,I 5
COUNTRY AND REFERENCE NO
NAKE OR INITIALS
DATE OF BIRTH
01 00.00.30
02 00.00.31
COUPA NY
I
| FIRST VC FACTORY | EXPOSURE
I ... I________
A | 01.10.56 \___________
1A.10.S7
DATE OF DIAGNOSIS
19.09.88 2S.09.70
ACE AT DIAGNOSIS
38 39
YEARS OF EXPOSURE TO
DIAGNOSIS
13
YEARS OF EXPOSURE
I
DATE OF I HISTOLOGICAL DEATH i CONFIRMATION
f
I 12 2S.01.69 |Yes (N10SH)
I
14.12.71 |Yes (NIOSH)
ESTIMATED EXPOSURE
LEVEL
OCCUPATION
Polyworker Polyworker
OTHER CAREER HIGHLIGHTS
1 | |
OTHER COMMENTS
1 03 l
1 1 1 1 1 1 1 1 1 1 { E f 1 1 1 1
04
11
11
1
1
1
100.00.30 1
12
1 12
| 09.06.S2 | 00.03.73 i
43
1
2L
11
11
1
1
11
11
1
1
1
11
1t
1
1
1j
11
1
i
11
11
1
1
11
11
1
t
1t
11
1
1
1t
11
f
1
11
1I
1
1
11
if
1
1
11
il
1
1
(1
11
1
1
11
(1
1
1
11
11
1
1
11
11
1
J
11
11
1
1
I1
11
1
1
00.00.30
\ 16.04.S7 26.11.74
17
11
1
1
16
j10.10.73 1Y.a (NIOSH)
1
1 1 Filling
1 |
(Reported undei
1 11
\ (pesticide |
|non polymer-
1 1J 1 1|
1 laerosol canal
1
|with VC
|
| LsatIon (workers in
\ tI
11
1
INIOSH 11st of
1 11
11
1
131.3*77.
1 1t
11
i
|Thls of courst
* 1(
1{
i
(is strictly
! 1i
11
l
Icorrect.
1 11
1l
1
(However I
1 11
11
i
| wonder
1 11
11
1
Iwhether this
1 J1
11
1
|nan had high
1 11
f!
1
fexposure to
1 11
t1
1
|VCM in hU
11
((
1
(can filling
*1
11
1
foperatIon?
1 J1
11
1
I
25.11.74 |Yes (NIOSH)
200-500 ppn Polyworker A 1958 was
I Clinlcal
J
but high
temporary
autocieaner {details 1
during L yr autocleaaer for 1 yr
{paper by
autocleaner
jCokel et al
i |Virchows Arc!
I |A Path 1976
|372 p 195-20
Page
CkKMANY Sheet 2
COUNTRY AND REFERENCE NO
NAME OR INITIALS
DATE OF BIRTH
(NIOSH gives as Case 06)
100*00.36
(NIOSH gives as Case 05)
00*00.32 00.00.26
08 00.00.17
1CI CHEMICALS 6 POLYMERS LIVER Angiosarcoma Cantu - (Review Date: 1 Jan 1969)
WPX/ASL - LANCIOCASES, 16
12 14 15
FACTORY
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
ACE AT DIAGNOSIS
YEARS OF EXPOSURE TO
DIAGNOSIS
YEARS OF EXPOSURE
DATE OF DEATH
HISTOLOGICAL CONFIRMATION
ESTIMATED EXPOSURE
LEVEL
OCCUPATION
OTHER CAREER HIGHLIGHTS
OTHER COMMENTS
02*04*60 f 10.12*73
35
13 05 16*12.74 )Yea (NIOSH)
16.12*62 | 00.00.75
'"15.04.54 | 12.11.75
49
12 09.01.75
21 (NIOSH
saya 12)
13.11.75
19.07.54 | 06.04.75
20 20 25.12.75
BG Chetale says "chemistry laboratorlant In the Technological Research Department" (NIOSH Bays assistant factory chemist which may be| wrong t ranslatIon]
PVC - Kamifacture Shift Leader
PVC Kamifacture and all work lncl autocleaning 12 yra ( 1954-66) Foreman Tech| Dev 8 yra (1967-1975)
Polyworker
?
fConf1 rued
(Reported under | non-polymer| Lsatlon (workers In |NIOSH list of 131.3.77 and 11.78. 1 don't Ithink this la |a correct fclassiflcation |by NIOSH. The Jaan may have |been Involved | In VCM (polymerisation (In pilot plant |or In main |plant.
1 1 1 1 t 1 1 1 1 1 1 1 1 1 1 j 1 1 1 1 1
GENC 008341
''K*
GERMANY Sheet 2
II
COUNTRY AND REFERENCE NO
NAME OS INITIALS
DATE OF BIRTH
COMPANY
GERMANY
(NIOSH gives as Case 06)
00.00.36
06
(NIOSH gives as Case 05)
00.00.32 00.00*26
08 00.00.17
tci CHEMICALS i POLYMERS LIVER AngloBArcou Cases - (Review Date: I Jan 1989)
WPX/ASL - LANC1DCASES,16
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
02*04.60 10.12*73
16.12.62 00.00.75
ACE AT DIAGNOSIS
38
YEARS OF EXPOSURE TO
DIAGNOSIS
13
YEARS OF EXPOSURE
DATE OF DEATH
t2
HISTOLOGICAL CONFIRMATION
n
I I
ESTIMATED |
EXPOSURE | OCCUPATION
LEVEL |
_________ I__________
16
f
OTHER
| OTHER
CAREER
( COMMENTS
HIGHLIGHTS |
___________ 1___________
05 16.12.74 Yes (NIOSH) 09.01*75
|0G Cheale Isays f"cheatscry |laboratorian |In the iTechno| logics! |Research | Department" | (NIOSH says (assistant | factory Ichealst (which aay be J wrong (translation)
1
I
|PVC - Kanu|facture |Shift Leader
|Conf1raed
I
|Reported under
laon-poiyaer| lsatlon |workers in j NIOSH list of 131.3.7? and
J l 78. 1 don't
I think this is (a correct |c lasslflea tion |by NIOSH. The faan aay have (been Involved (In VCM
| polymerisation fin pilot plant |or in aaln (plant.
15*04.54 12.11.75
49
21 2 \ 13.11.75 (NIOSH says 12)
J 9.07,54 06.04.75
58
20 25.12.75
J________________
|PVC Hanu| Facture and Jail work lincl autoJc leaning J12 yrs ((1954-66) (Foreman Tech |Dev 8 yrs f(1967-1975)
I
|Polyworker i
GENC 008342
P.ge
COUNTRY AND REFERENCE NO
NAME OR INITIALS
DATE OF BIRTH
COMPANY
GERMANY
00.00.34
10 (NIOSH gives
as Case 11)
00.00.36
(N10SH gives as Case 10)
00.00.29 00.00.38
ICI CHEHICj
LYHERS
LIVER Anglosarcooa Cases - (Review Date; ) Jan 1989)
UPXMSL -
(JCASES, I )
10 12 13
15
FIRST VC EXPOSURE
DATE OP DIAGNOSIS
ACE AT DIAGNOSIS
YEARS OP EXPOSURE TO
DIAGNOSIS
YEARS OP EXPOSURE
DATE OP DEATH
HISTOLOGICAL CONPtRMATION
ESTIMATED EXPOSURE
LEVEL
OCCUPATION
OTHER CAREER HICHL1CHTS
OTHER COMMENTS
20.02.61 16.06.76
41
15
24.03.78
01.01.61 00.01.77
40
07.03.77
10.10.55 28.06.77
47
22 28.06.77
00.00.61 00.10.77
16 07.10.77
High peaks
12 yrs poly worker Incl 172 auto clave cleaning Control room 1 yr
High peaks
10 yrs polyworker lncl (7X auto clave cleaning
High
3 yrs auto clave cleaner 19 yra filter operator
PVC Manu facture Autoclave worker Cor 6 yrs
10/78 Conf 1 rtaed Average exposure first 9 yrs J 50 ppo, occ 1000 ppo. Next 3 yrs avr 75 ppo. Last. yr av 35 ppo
Average exposure first 9 yrs 1 50 ppo > occ 1000 ppo. Last yr av 75 ppo. CWH letter of 21.04.78
GENC 008343
J.
Page
GERMANY Sheet 4
1t
COUNTRY AND REFERENCE NO
2
NAME OR INITIALS
3l |
DATE OF | BERTH |
4 COMPANY
I
GERMANY 13
00.00*14 1
7
14
15 (NIOSH gives| this as Case 13)
16
00.00.29 |
8
00.00,23 l
4
TCI CHEHICA1
POLYMERS
LIVER Anglosarcoaa Cases - (Review Dace: l Jan 1989)
WPX/ASL - LANCIOCASES, 18
516
------------?-----------
1 | FIRST VC
DATE OF
FACTORY | EXPOSURE DIAGNOSIS
1
1 i
i
1 7 { 00.00.60 08.04.76
i
i 1
i
J
t
1
1 *
1 1
1
i t 1
1 1
i
8 AGE AT DIAGNOSIS
63
1 1 1 1 i i A 1 lA.10.S3 09.10.78
1 1 1 1 r i i 1 4 1 10.01.55 07.08.78 1 (Leibach 1 suspected 1 ASL st 1 Feb 1975 1 laparotoay) 1 1
1 1 1 1
1
i 1 1
44 55
9 YEARS OF EXPOSURE TO DIAGNOSIS
18
a
23
10
YEARS OF EXPOSURE
u
DATE OF DEATH
12
HISTOLOGICAL CONFIRMATION
13 i 14
ESTIMATED EXPOSURE 1 OCCUPATION
LEVEL
15
OTHER CAREER HIGHLIGHTS
1 1 1 l 1
i
16
OTHER COMMENTS
14 19.05.7&
Yes
Not sn Anglossrcou In his letter of 21 12 81, Hr Friedel said this was a "Platteneplthelkarrlnoa Der Spelserohre4* (a carclnoaa of the oesophagus) not attribute able to VCH A not recognised as an lndustrial disease
14 13:i07J4
Yes
!
? I Autoclave (cleaner and |worker. |Drier (operator. (Later shift 1 leader
20 07.08.78
Yes
High (Autoclave
ASL and
jworker till
flepatocellular
1J 964.
Carclnoaa
JLeader and
inaster
|F W Seat lletter of 130t h June 196 (enclosing dat | from (Mr H P Frtede | o f BC Chen 1 e IF U Best lletter of |30th June 198 (enclosing dat | f ron |H P Friedel o | BC Chenle (withdrawing 11 his case
J |
E | |
i | |
1
(Anglosarcona Iconf lmed 109/79. Some (detail of this f& also cases 19. 13. 15, 16 |& 17 given In (NRW Report foi 1 1978 | Anglosarc o<aa Iconf 1 raed , iful1 details |of illness Islnce March 1 1973 given in j NRU Med 1nsp |Rep for 1978. |Dl f f erent (details given (in "VC (Associated JDUeafie" liy [Leibach and JMa rst e 1 le r |(19HI) P7I.
V SEMC 008344
Psge
GERMANY Sheet 5
2
COUNTRY AND REFERENCE NO
NAME OR INITIALS
DATE OF BIRTH
GERMANY
17 (NIOSH gives as Case 15)
00.00*17
18 1 1 1
19 1 1 1 1 i
20 1 1 I t 1 1
21 1 1 \ 1 1 1
22 1
1 1 i
100.00*13
1 1 100.00.15
1 I 1 1 100*00.15
( 1 1 1 1 100.00.13
1 J 1 1 1 100*00*21
1 1 1
ICI CHEMICA^W^ POLYMERS LIVER Angiosarcoma Cases - (Review Date: J Jan 1989}
WFX/ASL - LANGIOCA5ES,l9
12 13
15 If:
FACTORY
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
ACE AT DIAGNOSIS
YEARS OF EXPOSURE TO
DIAGNOSIS
YEARS OF EXPOSURE
DATE OF DEATH
HISTOLOGICAL CONFIRMATION
ESTIMATED EXPOSURE
LEVEL
OCCUPATION
OTHER CAREER HIGHLIGHTS
OTHER COMMENTS
01.LI.61 14*08.78
41
5 1 5 1 00.00.55 t 25.12.79 I 66
24
11 1 1
11 1 i
4 1 4 1 10.10.54 | 00.08.79 | 54
25
11
1
1
11
1
1
11
1
1
11
I
1
4 * 4 f 14.02*61 | 00.04.80 I 65
19
if
1
1
11
1
11 i f
l1
i
1
1
fi r 1
4
4 | 01.01.62 | 00*09*79 1 66
1
18
1 (pronounced |
*
1 (clinical I
1
1
(liver
I
1
1 Isymptoos) |
11
1
J
f
4
4 | 15.10.61 f 26*08.80 t 59
1
19
l1
1
1
1J
1
1
11
1
t
28.08.78
1 21 125.12.>9 1
Yes
11
l1
1 16 |22.0i.80 j
Yea
1 1 (Metastaslng f 1 |ASL
11
11
i 13 119*10.60 1
Yes
i 1 IHaesangio
i 1 | Endothelioma
i J (of liver with
i f IHetastaees
j1
i li 119.06.80 t
Yes
I ( (Haemangio
i 1 |Ecidot he Ilona
( 1 |of liver with
i 1 (Metastaaea
i\
iJ
106.12.81 J
Yes
1 IMetaataslng
1 | ASL
f
High
Autoclave worker
Ang 1 osarcotia
confirmed. Annual report of the North Rhine Westphalia Medical Inspectorate Cor 1978 pages 347-377 gives full detalla. Vinyl chloride disease d Lagnosed 02-02-73. Oesophageal varices. Radiologica11/ confirmed aero
High High High High
(Autoclave I Worker
| |
1 1 Autoclave
1 Worker
1 1
1
1 1 1 |Autoclave IWorker
1 1 1 1 |
11
11 11
1 |Autoclave
1 |
IWorker and (
|worked In | Idrylng shop |
11
11 |Autoclave |Chargehandf
IWorker 1 |
|subsequently
|Foreman
|
1 1 1 |Dr Besche lletter of |J 3-04--a2 to jDr W C F Adams
1 | Dr Besche lletter of 113-04-82 to JDr W G F Adams
1 1 |Dr Besche lletter of 113-04-82 to f Dr U C F Ad anis
1 1 |Dr Besche fleeter ot |13-04-82 in | Dr W C F Adam*
GENC 008345
GERMANY Sheet 6
ICI CHEHICA
OLYMKftS
LIVER Angiosarcoma Cases ( Rev Date: I Jan 1989)
WPX/ASL - LANCLOCASES.2U
COUNTRY AND REFERENCE NO
NAME OR INITIALS
DATE OF BIRTH
GERMANY 23
00.00.27
24
25
26
27
28 1 1 1 1 l 1 1 1 1 1 ( 1 1
32
00.00.28
00.00.23
00.00.22
06.00.28
121 ii.iTi 1i 1) 1* 1l ti 1* 1l 1l Il ii 1i 1l
00.00.22
J00.00.17
00.00.23
00.00.30
10
12 13
14
FIRST VC FACTORY EXPOSURE
DATE OF DIAGNOSIS
AGE AT DIAGNOSIS
YEARS OF EXPOSURE TO
DIAGNOSIS
YEARS OF EXPOSURE
DATE OF DEATH
HISTO LOGICAL CONFIRM ATION
l ESTIMATED | EXPOSURE | OCCUPATION
LEVEL |
15
OTHER CAREER HIGHLIGHTS
I 1 |
| !
J6 OTHER COMMENTS
1955
26.03.79
21 29.09.81
i High |Chenlstry {*300 pp) (Worker
1964
TiTTOT
54
1960
2i.o4.Sl
T55T
li.06.1t
1T 12 28.05.63
IT 14.01.83
22 22 i2.ll.82
High {Autoclave (*300 ppn) |Cleaner
High|Polyclave (Worker and I Autoclave ICleaner
_____ |________
High |Polyworker
15T
18.01.43
55
26
T~ 1 1 1 1 1 ( J ( 1 1 1 1 l
T 1 01.10.80 1 11.08.85
11
11
f1
11
11
t
11
11
f1
1i
11
t1
1962
15.02.83
i 1 1 1 1 1 1 1 f l 1 1 i
il 61
1951
o?Toi.eo
62
1953
30.06.85
1955
00.04.85
55
i
1 1
15
TT
02.03.84
1 25 II5.08.8S 1 Yea 1
1
11
1
1 (li
1 11f
1 1ri
!1
i
1 11I
l 1t 1
1
11
1
J t1l
( 11I
1 11
( i11
5.02.84
25 25.05.83
20 Alive?
21 Alive?
High
1 |Autoe lave |Cleaner till j 1972
High High
(Process
|
(worker 1947--|
|84 (01.10.60)
1-31.03.84 )
(PVC product-1
|lon,
|
(agitator 1 rea).
| |
1|
11
1|
I|
i (Chenlstry
r
(worker
High
(Polyworker |Shift leader
(Autoclave leleaner I f Po lyworker (Autoclave |c I eancr
\
|Primary hepatoceltar Icarctnona; {proliferation of the (slnuslodal cells with lalnusotdal ectasia. IFrlectel letter 23. 12.86.
1 Prof Eder fHunlch) ll.tter 22.08.83. (Frledel letter 19.04.85.
IProf Selnalr (Munich) {letter 22.08.83. IFriedel letter 19.04,85
t
I_____________________ |Chronic hepatitis, (anglonatoeis, einusolda l lectasla. Frledel letter ) 23. 1 2.86.
JLelbach. IFriedel letter |19.04.85
{Annual VCM screening 124.04.85: no coaplaint , (no abnormality detected. 11970 two-thirds (gastrectomy for ulcers. (1971 Coronary thrombosis |1983 Feaoral |lnplantation 11984 Pulnonary embolism (and pleuropneumonia. |Landers letters 18.09.85 land 04.02.87. 1 |Haenang1osa rkona, |Frtedel letter 23,12.86. t |Haenanglosarkoma, (Frtedel letter 23.12.86, i |Haemanglosarkona, | Frledel letter 23.(2.86.
i jHaernangf osarkoma. (Frledel letter 23.12.86. I 1
GENC 008346
i*
ft
Page
ITALY Sheet I
16
ICJ CKtiHIC.
POLYHEKS
. LIVER Angiosarcoma Casas - (Review Date: 1 Jan 1989)
UPX/ASL - LANCIOCASKS.2
*7
1 |3
11
11 COUNTRY AND | HAKE OR | DATE OF
REFERENCE | INITIALS | BIRTH
NO 1
1
4 COMPANY
1t |516 i 7
1t
1
1 FIRST VC
DATE OF
1 FACTORY i EXPOSURE DIAGNOSIS
1
e
ACE AT DIAGNOSIS
9
YEARS OF EXPOSURE TO
DIAGNOSIS
1 10 1 H
1 1 YEARS OF 1 DATE OF EXPOSURE t DEATH
i
12
HISTOLOGICAL CONFIRMATION
i 13 i
j 1
ESTIMATED 1 EXPOSURE 1 OCCUPATION
LEVEL 1
15 1
16
OTHER CAREER HIGHLIGHTS
| |
OTHER COMMENTS
ITALY
t 1
1 1
1 1
j 11 i 11
1
01 |LC
|15.06.34 PANSAC
|Mlra
1 00.00*65 19.04.71 t
36
06
03 |16.04.71
?Yes
(On NIOSK 1
1t
|Venice i
i
supple-
1
1
i
1
sentary
1
1
1
1
list)
1
1
1
1
I1
1
I
11
1
1
1PVC Bag lextruder
i i 1 1 1
|Primary tunou |*ay have been |pericardium.
|Not homoIgeneous with (other cases. 1* * *
11
1
1
11
1
1
02 |SE
|13.11.29 Montedison 1 Porto
1 00.00.57 13.12.72
43
15
06 127.12.72
Yea
1
1 | Polyworker
l 1*
t1
IMarghera
1 1 J"
1 1 03 | VC
1 1 1 1 1 1 04 jFB
1 l 1 1 1 1 I 1 1 1
1 1i
1 1
|14.03*20 i Solvay
| Ferrara 1 00.0t.53 10.07*75
55
22
ii
i
i
t 1i
11
11
i 1 120.07*37
AHIC
1 !i
ii
I
1 Ravenna i 00.04.59 i 00.01.B1 I
43
21
t 1t
1
11
1 1i
11
i 1I
11 1 ri i
11
11
1 1 21 |10.07.75
1i 1 1 1
i 1 21 130.03.81 1i 1i 1 1 ii 1i
i 1 1
Yea Yea
High
12 yra Very High
5 yra Medium
4 yrs Low
1
1 |Autocleaner
] 1972-5 did
|8 yrs (1953- a variety of|
|61) Autoclave Jobs
loperator
including
1 1
**
112 yra (1961 - PVC packing . 1
172)
1
1*
|l yr -
Never cleaned
| Monomer
autoclaves. 1
[operator
See paper by 1
**
1 |20 yrs -
CH1APPINO et | Non-smoker. al Med Lavoro |Consumed
|Autoelave
Vol 6 1982) 11ittle
loperator 6 pp 555-563
lalcohol. No
lother duties
f A0L.
|in suspens-
1
lion polyaer-
\
|isatIon.
\
11
1i
1
11
1
11
1
11
I
1i
l
05
|G Daneain I 19.03.37 PANSAC
| til ra
S 00.00,67 07.03,83
11
|Venice
11
1
11
l
11
l
1t
l
46
j
1 |Area Foreman
1 |ln sane Dept
J |slnce 1975.
11
11
11
16
8 106.04,83 1
Yea
|Medium-? j Bag ext ruder
11
1 High
1 1967-1975
11
LCommercial
11
IDept 1976-
1 11
1 1983
1 11
l
1 \
) | S Pagl la 1 ung. | telex of
| 2 Aug 1 98 J
|
i
* See HaLtoni Med dl Lavoro 65 p445, 1974. further details in letter Iron Dr Montesano of 1ARC on April 1st 1982.
** Also see Maltonl and Rondlnella In Acta Oncologies Vol 1 I960 pages 35 - 49.
* i &.
GENC 008347
9~
Page I J
ITALY Sheet 2
1C I CHEMICALS & POLYMERS LIVER Aagtosarcona Case6 - (Review Date: ] Jan 1989)
WPX/ASL - LANCIOCASKS,22
COUNTRY AND REFERENCE NO
ITALY
1 12
I
11
| INAKE OR |
I INITIALS)
1 l 1
3
DATE OF BIRTH
1 1 J 1 1 |
1 1 1
4 COMPANY
1 ii
1i
11 1 1
1 5 16
| 7 1 8 19
1 io 1 ) 1
1
17
1 13 | 14
| 15 1
1 11 1 I1
|YEARS OF
1 11
11 i1
11 11
1 | FIRST VC IDATE OF |AGE AT |EXPOSURE |YEARS OF| DATE OF (HISTOLOGICAL!ESTIMATED]
|OTHER
!
| FACTORY |EXPOSURE |DIAGNOSIS |DIAGNOSIS|TO
fEXPOSURE! DEATH I CONFIRMATION|EXPOSURE OCCUPATION (CAREER
1
1 |1 11
ID1ACNOSISI 1*
1 I
I
(LEVEL l
| 1
|HIGHLIGHTS! 1!
1 it
t1
11
11
16 OTHER COMMENTS
06
1 cz
121,06.36 j Montedison 3 Porto
|01.10.60 |06.12*85 |
49 1
25 1 25 |13.02.96 | Yes
1 High
| PVC
|
1 Letters iron Dr Chlozzlnl, Venice,
1
1
IKarghera |
1
1|
11960-71 |aanufacture|
1 22,09.87 and 11.01.83
1
1
iVenlce |
1
J3
| Medina | J1 years as|
1
1 l 1|1 I 1 I11
J3 11
11971-74 |Autoclave |
| Low
Icleaner
|
1 1
11
|1
1 1 1 |1
11 1I
11975-35 11960-71. | 1 114 years in|
1 1
3 1 1 |1
) l 1 3 11
1 11
1
1 1 1 I 1j
1I
11
1 1
!
1
|Cont:ol
|
i
|Rooa
|
I
11971-85
|
i J1
1 1 1 1
11
t1
1
I1
1J
07
| AP
109.02.25 (Hoplefan |Terni
| 19S6 I2L.01.86 |
60 |
23 | 22 105.04.86 1 Yea
|1958-74 (Maintained |
i Inforaatlon fron La aedlclna del
1 1 1|1
I|
1 High |VC Machinery
1 Lavoro, Italy, Vol 79 No.1
1 I 1|1
1i
1
Knot
|
1 Jan-Feb 33, and Dr Renetta,
1 1 1|1
* 1 1|1
/ 1 1 1|1
|j
1
|
1 J
1|1 1j1
1 i1
1
*1
Ji
I1
iI
11
11
1
1
1
|1974-80
1 Medina
i
loperating |
|or cleaning!
lautoclavea)|
|VC levels |
(reduced fro*
1 1973/74
1
1 EnlCheta. 1 1 1 1 1
ii III
111
j
| | |1 1
1 11
1 1
i J!
II
1 IJ
III
|
|
|1
I
11
1
II
II
III
III
|j
1
1
1
11
1
11
1
|
|
11
1
11
J
| | J 1 1 11 J
II II 1J
II II II
III
1 1 1 1 t 11 i
1J
II
III
1
1
11
1
1t
I
II
11
?
III
1
I
11
1
1f
1
II
II
III
|
I
|1
1
11
1
II
II
III
l I 1 l l 11 (
II
II
|1
j
I I 1 1 1 11 1
II
II
III
1
I
11
1
11
1
II
II
t
I4
I1
4J tt
*l I*
i t *
i
11
003348
F
Page JAPAN
ICI CHEMICALS A POLYMERS LIVER Angiosarcoma Cases - (Review Date: ) Jan 1989)
WPX/ASL - LANCI0CA5ES,2 3
COUNTRY AND REFERENCE NO
NAME OR INITIALS
DATE OF BIRTH
01
Toaoji
01.08.22 Mitsui
Nagoya
Marl
Toateu
02.08.39 Kanegafuchl Osaka Chemical
1 03 | YS
1 1 1 i i
11 101 09.30 (Mitsui 1 iToatau 11 11
11
11
i 1Nagoy*
1 1 1 1 1
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
AGE At DIAGNOSIS
00.04.33 24.10.75
53
00.11.56 10.08.76
11 < 00.07 65 | 26.06*85
11 11 11 i1 il
1 1 1 1 1 1 (
54
10 11
YEARS OF EXPOSURE TO
DIAGNOSIS
YEARS OF EXPOSURE
DATE OF DEATH
HISTOLOCICAL CONFIRMATION
ESTIMATED | EXPOSURE | OCCUPATION
LEVEL | ______________ I_______________
OTHER CAREER HIGHLIGHTS
i |
j j
OTHER COMMENTS
24.10.75
1 PVC Aaaoc |13 yrs auto
says not (clave
known*
(cleaner
l
* Japan
I 1964 -
J
Times
lasslgned to (
indicated (different j
on 25.10*75(work since |
exposures (bad 111
]
often at Jhealth
|
3000 ppm upl
1
to 1974 |
*
10.08.76
I (In polymer-
|ieatloa work (including
(autoclave
Icleanlng
I
1 11
11
1
20
J 5 | 14.09.85 1 Yea
| High (5 years
f
1 11
1 |Autoclave J
1 11
1
| cleaner
|
1 11
11
i
1 11
1J
i
1 11
1\
t
I
|Japan Tines (25.JO.75 6 IJapanese PVC |Aaaoc letters (of 31.03.78 tr 130.11.87
J
|Japanese PVC | Assocl at ion lletters of (31.03.78 6 |30*J J.87 J
ILetter from |Dr Nakaaura, (Japanese PVC | Aaaoc la t ion |30.11.87 1
SENC 00634?
T
Page
19
NORWAY
COUNTRY AND REFERENCE NO
NAME OR INITIALS
DATE OF BIRTH
[Cl CHHlWi^4 POLYMERS LIVER Angiosarcoma Cases - (Review Date: 1 Jan 1969}
WPX/AS1^^ANCI0CASES,24
12 13 J4
15
FACTORY
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
AGE AT DIAGNOSIS
YEARS OF EXPOSURE TO
DIAGNOSIS
YEARS OF EXPOSURE
DATE OF DEATH
HISTOLOGICAL CONFIRMATION
ESTIMATED EXPOSURE
LEVEL
OCCUPATION
OTHER CAREER HIGHLIGHTS
OTHER COMMENTS
01
23.12.15 Norsk
jHeroya
00.03.50 } 21.12.71
Hydro
22 21 (04.01.72
High
Foreman 4 Autoclave supervisor
| | \
1 1 1 1 1 1 1 1 I 1 i l
(Confirmed by |Dr Thlis-
(Evansen of N | At APME Mtg |9 June 1978 [Hr P Rangneti | stated that (had been a Inember of a (start-up tea | VCM t, PVC we Jaade In sane Ibullding. 1 |VCH was mad* (frco acetyl*
GENC 008350
Page SWEDEN
20
COUNTRY AMD REFERENCE NO
NAME OR INITIALS
DATE OF BIRTH
COMPANY
ICI CHEMICALS & POLYMERS LIVER Angiosarcoma Cases - {Review Date: 1 Jan 1939)
UPX/ASL - LANGI0CA5ES,25
n 15
FIRST VC EX POSITRE
DATE OF DIAGNOSIS
ACE AT DIAGNOSIS
YEARS OF EXPOSURE TO
DIAGNOSIS
YEARS OF EXPOSURE
DATE OF DEATH
HISTOLOGICAL CONFIRMATION
ESTIMATED EXPOSURE
LEVEL
OCCUPATION
OTHER CAREER HIGHLIGHTS
OTHER COMMENTS
01
23.06.27 Keaano rd
J4.08.5l 20.10.70
20.10.70
27.11.11
Sundsvall 00.01.45 00.06.72
61
27
27 16.06.72
Polyworker
High
VCM production
Mr Sj oe H nT s letter of 28 March 197J confirms BL was a monomei worker who vc heavlly exposed, probably evei more so than a normal reactor cleaner
03
10.06.10 Kemaaord Sundsval1 00.05.47 18.03.76
65
29
21 19.03.76
L6.H.14 Rena no rd
12.05.77
31 12.05.77
High
Polyworker
High
1946-1956 polymer isation wo rker (12 yrs) t 19581977 foreman C19 yrs)
In f i rsc L 2 yrs of employment h, been heavily exposed. In J974, liver abnormal 1ty and necros 1 a diagnosed. Data confirm? Jin Dr D Byrei letter 18.8.7 to CEF1C
05
12.03.19 Kemanord
11.05.64 22.11.80
16
16 22.11.60
Yes
High -
1964-1970
6 Years
centrifuge
Low -
operator
10 Years 1970-J980
drier
operator
Letter of 2nd Nov 198! from Dr David Byrt
* In his Letter of 1st April 1982, Dr Hontesano of IARC says in Sweden's National Board of OS Health gives 20-02-70 as date of diagnosis for Case 0| and 15-05-72 for Case 02.
GENC 003351
Page 21
UK Sheet I
REFERENCE NO
UK 01
1 t2 1
1 13 1
it l SAME Oil 1 DATE OF
1 INITIALS 1 BIRTH
11
|1
1
t1
i1 |UJ 120.04.01
l1 |
11
I|
1 1 1
1 1 1 03 | BJtf
1 1 1
|
1 1 1 102.06.37
1 1 l 04 | JSR |
i i
i 123.06.20 |
||
||
||
11 lt
11 11 11
f1 1
11
11 11
4 COMPANY
1 |5
1 1 1 | FACTORY
1 1 1 1
6
first VC EXPOSURE
ICI /Hlllhouse 04.04.44 1 I
1
1
1
1
1
|
|
J
1
i
BP
l*.rry
00.02.66
|
1
1
1 ICI iHlllhouse 26.04.54
t
| | | |
1
1
1 * | |
1
I
1
1
1
1
1
1 1
1
1
1
ICI CHEMICALS A POLYMERS LIVER Angiosarcoaa Cases - (Review Date: l Jan 1989}
1
78
9 | 10 1 U
12
DATE OF DIAGNOSIS
AGE AT DIAGNOSIS
YEARS OF | YEARS OF | DATE OF EXPOSURE TO | EXPOSURE I DEATH
DIAGNOSIS
HISTOLOGICAL CONFIRMATION
03.12.72 (Fox 6 Collier
paper says 23.12.72)
71
28 | 22 103.12.72 |(Fox 6 |Collier
Yes
|paper
| ssya
123.12.72)
00.12.74
37
00.06.79
59
09
1 3.5
124.12.74
j 25 J 18 112.10.79
Yes Yes
UPX/ASL - LANCIOCASES,2 b
1
n 1 14 1
1
1
EST LMATED 1
|
EXPOSURE 1 OCCUPATION j
LEVEL 1
|
1
t
i
15
OTHER CAREER HIGHLIGHTS
500 ppa
High Med Ilmhigh
11944-7 VCH
11947-8 Drlerl
11948-61
|Autoclave
loperator
|1961-66
(Drler
1
1
1
1
1
t
1 (Autoclave
Jc leaner
1
1
1 154-5
|Pre-war fish
I Bagging
|packer
(Plant
I 1939-45 arny
155-6
/vehicle
|Drter Plant laalntenance
156-58
|Autoclave |worker
11945-54 /fish packer
158-61
(Chargehand
/Drier
|Plant
f
161-72
|Foteaan
1C 2/3 Plant
11
1
1
1
1
1
1
1
1
t 16
1 | OTHER | COMMENTS
1 1 1 1 \ |Lee and Harry (Lancet |29-06-74 /pages 1316-8
S 1 1 1 1 |Dubious 1fabrLcation |csse
1 1 |Exposure (Halted to 12.66 - 9.69
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
1 f 1
1 1
1
003352
genc
Page 22
UK Sheet 2
L 1 2 -------- i---------5---------
11 COUNTRY AND 1 NAME OR | DATE OP
REFERENCE 1 INITIALS 1 BIRTH
NO 1
i
UK 05
1 |JK
1 130.03.14
4 COMPANY BP
|5 | FACTORY | Barry
ICI CHEMICALS & POLYMERS
WPX/ASL - LANG10CASES,27
LIVER Angiosarcoma Cases - (Review Date: 1 Jan 1989)
5 --n------------- ,-----------
6 ----------- -----------
i
L0
12
li
14 |
15
FIRST VC EXPOSURE
08.01.51
DATE OF DIAGNOSIS
00.L0.79
AGE AT DIAGNOSIS
YEARS OF
YEARS OF DATE OF
EXPOSURE TO EXPOSURE
DEATH
DIAGNOSIS ________ ______
HISTOLOGICAL CONFIRMATION
ESTIMATED EXPOSURE
LEVEL
OCCUPATION |
OTHER CAREER HIGHLIGHTS
65 2B t I I | | l I I
j
I i
| J
21 19.11.79 III III III III III III III III III I II III
III III
1951-52 I |Polycleaner II1952-55 I |Late* I 11955-60 I |Polyfloor I 11960-64 I I Poly I iChargehand
I |1964-70
I |Charging I loperator
I |1970-72 I JDrler
operator
I | | | t 1 | I | f | | I f
16
OTHER COMMENTS
06 "oT
1931 26.04.20
Barry
1962
09.01.80
98/9
18
TT
09.01.80
Barry
tsst"
00.00.80
~5o"
TT
XT 177505"
7 yra Poly Floor Operator 5 yrs Greaser on Poly Floor Po lyc leaner 1963-5 Recovery 1965-1971
08
08.05.24
Barry
i9.09.5d' 27.11.81
IT
TT
TT 25.12.81
)
1 1
I
{
1950-1958 500 ppm 1968-1974 200 ppa
1 1950-5!
11938-1948
|Autoclave (Motor Mechanic
|operator
1 1948-1950
| 1951-1957 [Operator on
IChargeaan [Acetylene
(autoclave | Production
(building
[Plant
|1957-1974 iShift supervlsor
1 1
autocLave
building -
Never
c leaned
autoclaves
but
supervisor's
job entailed
enter Lng
autoc Laves
to Inspect
then
GENC 008353
Page
23
UK
Sheet 3
COUNTRY AND REFERENCE NO
UK 09
HAKE OR INITIALS
DATE OF BIRTH
07.05.25
04.04.47 08.05.28
JT 24.01.37
Barry Barry
IC1 CHEMICALS A POLYMERS
UPX/ASL - LANCIOCASES ,28
FIRST VC EXPOSURE
15.02.50
LIVER Anglosarcona Cases - (Review Date: 1 Jan 1989)
T 10 11
DATE OF DIAGNOSIS
ACE AT DIAGNOSIS
YEARS OF EXPOSURE TO
DIAGNOSIS
YEARS OF EXPOSURE
DATE OP DEATH
02.03.83
58
33
29 24.02.83
12
HISTOLOGICAL CONFIRMATION
13 14
J5
ESTIMATED EXPOSURE
LEVEL
OCCUPATION
OTHER CAREER HIGHLIGHTS
Med lua
Polyworker
2 years on Acrylonitrile Realn Plant. Also prior to 1950. 4 years RAF Maintenance. 3 years notor car paiatshop.
2 years In Graving Dock.
OTHER COMMENTS
27.04.66 01 05 B4
18 4.2 16.05.84
High - It Polycleaner
onths (500 1966-67.
ppa). Low- Spray-drier
18 aontha <50 ppa).
.bagger 1967-
68
Medlua -
Blow-down
21 aontha atripper
(200 ppa) operator
1968-70.
Heavy goods
lnforaat Lon
vehicle driver given In
until final
letter
lllnes.
18.06.84 from
Or D H J
Ui LlLaas
19.12.65 02.06.85
57
19 16 02.06.85
16.09.57 03.06.85
48
28 06.L2.85
High 1965 -69 Med 69-79 Low 79-82
Polycleaner 1965-68. Service operator 68-69. Poly Operator 69-79. Leading Hand 79-82.
Low 1957-59 Spare nan. High 59-74 bagging Low 74-85 floor
1957-59. Autoclave Operator 1959-85
Letter of 04.06.85 Dr Paul Smith and letter of 04.06.85 Dr D H D Evan: Oesophagea L haeaorrhage due to oesophagea L varices due Angiosarcoma of liver
Letter 26,06.85 Dr F 1 Lee
GENC 008354
Page
UK Sheet 4
COUNTRY ANO (NAME OR DATE OF REFERENCE 11N1TIALSI BIRTH
NO
UK (MJ |02.03,48 IBP
ni
1
1
1i
1
t1
l
1I
1
1l
1
I1
l
1!
1
*1
1
11
1
u JGS | 15.06.42 |BP
ii
i
11
1
tI
1
1I
1
l1
1
1(
1
lI
1
i1
1
i1
1
11
1
15
(BCP
123.03.21 IBP
11
1
ii
i
i1
1
11
1
11
1
11
1
11
1
16 | RT 125.05.22 | ICI
11
!
t1
1
11
1
II
1
i1
1
ICI CHEMICALS 6 POLYMERS
WPX/ASL2 - LANG 1OCASES,8
LIVER Angiosarcoma Caeca - (Review Date : J January 1989)
12
(FIRST VC FACTORY |EXPOSURE
YEARS Or
DATE OF AGE AT l EXPOSURE YEARS OE(
DIAGNOSIS! DIAGNOSIS [TO
EXPOSUREl
DIAGNOSIS)
DATE OF DEATH
IHISTO-
(LOGICAL ESTIMATED!
J CONFIRM-) EXPOSURE
I ATION
LEVEL
OCCUPATION
IS
OTHER CAREER HIGHLIGHTS
OTHER COMMENTS
1 Barry
| 1968 | Jan 86 1 37
IS 1 3
(02.06,86 ( Yea 1 High | Polyc leaner
| Moved to
|Regained well, working
t
1I
11
1l
11968-69
| Acrylonitrile (actively, until Jan 1986
1
11
11
1 | Low |Central IPlant until
1 11
l1
I1
(Depot
(left BP 1983.
i
1(
11
11
11969-70
(Manager of
l
11
11
l
1 High 1 Polyfloor
|1C 6 SS Ltd at
l 11
1i
i1
|1970-1971
(Cardiff Airport/
1 1i
11
l1
11983-86
i 1 i 1( 1 1
l
11
1y
i1
(
|Barry
(07.07.66 (27.08.37 1 45
21 1 1L
101.12.88 | Yea |10 monthelPolycleaner
(Letters from Dr DUD Evans,
1
ii
1i
t
(High
|1966-67
(Pathologist. Penarth, Wales
i
it
li
i (10 year. |Polyfloor
land Dc DHJ Williams, BP, Barry
1 1 i i 1 i i Iconstant Jworker at tinea|
l
i1
1i
t 1Medium (between
1 1 i i i i i |but OD |1968-L982
1
ii
1i
i (inter*-
1 1 1 i i i i Imlttent
l
(1
1
i I Jobe
1 1 ( li i 1
1 I Berry
11956
1 11988
i i 66
1 32 1 16
11 I 01.05.881 Yea
1 (9 years (Poly cleaner 6 )
(Information froa
1
11
1i
i
1 High (Operator
^Exposure
| Dr D M J Williams, BP, and
1
11
ii
i
|5 yeara (Blow 6 Recovery 7 periods
(Dr Paul Smith, Pathologist 1981
I i1
1i
i
| Medium |Operator
'intermittent
1 1 i i i 1 1 12 yeara (Utility
1 1t
1
1
1 Low
|Operator
1
11
11
11
l
11
1l
11
|H1llhouse 1 1963
J1988
1 66
25 12 1 12.11.861 Yea 11 year > |Packer
(Hepatic fibrosis 1974
1
11
\1
1 1 Low )
!
11
11
1 J9 years)
|Oesophageal varices |Porta-caval shunt 1975
i
1t
1i
1 1 High ) (Autoclave
1
11
li
i |2 yeara) (Operator
1
11
11
1 1 Low )
(Information from Dr B Bennett, |ICI, and Dr F 1 Lee, Blackpool {Victoria Hospital 1988.
^ jk
T
GENC 008-
A
Page
USA Sheet 1
25
ICl CHEHICALS A POLYMERS LIVER Angiosarcoma Cases - (Review Deter I Jan 1989)
10
UK system of dates DAY - MONTH - YEAR
12 13
VPX/ASL - LANO1OCASLs ;29 15 16
COUNTRY AND REFERENCE NO
NAME OR INITIALS
DATE OF BIRTH
USA 01
02
03 04 05 06
1 1 \ |Earl
i 1 1 117.10.23
BFG
]Parks
|
]1
I1 ||
ii
ii
11 | 119.08.33 BFG
i i1 I1
ii
ii
1 1 Edward
1 125.05.15
(Dinwiddle 1
8FC
11
ii
11 | | 15.01.24 BFG
it ii 11 | 125.01.(2 BFG
ii
ii
i |Ray
i 123.11.26
BFG
Austin Jones?
FACTORY
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
ACE AT DIAGNOSIS
YEARS OF EXPOSURE TO
DIAGNOSIS
YEARS OF EXPOSURE
DATE OF DEATH
HISTOLOGICAL CONFIRMATION
ESTIMATED EXPOSURE
LEVEL
OCCUPATION
OTHER CAREER HIGHLIGHTS
OTHER COMMENTS
1 1 |LoutsI vllle
l t 1 1 1 S (Louis| vllle
1 1 l 1 1 Louis| vllle
( ( 1 (Louis| vllle
1 1 (Louis( vllle
1 1 (Louis-
1 09.12.48 1 03.03.73 1
1 | 15.11.55 1 00.05.70
( 28*11.45 19.12.73
( 06.07.52 19.08.67
| 19.06.44 09.04.64 1
| 17.01.02 1 00.02.74
( i i 1 1 1
1 1 ! i
1 1 1 1 1 1 1 1 1 l 1 1 ( 1 1 1 1 1 1
49
37 58 43 52 45
i t
24
14 28 15 20 12
1 11
1 11 1 21 103.03.73 |
1 11 i 11
1 1 1 1 r 1 -13
i i i
ti
11
11
11
11
127.09.71 (
| (N10SH 1
Isays
|
128.09.71)1
( 11
j 11 | 28 (19.12.73 1
1 ii 1 1t
i ii
1 l1 1 13 (07.01.68 |
1 ii t ii 1 11 1 20 (09.04.64 |
1 ii 1 ii
1 ii 1 12 120.07.75 |
Yes
Yes Yes res Yes Yes
1 1 |
1 1 1 1 1 1 1 (
1 i 1 l 1 |
1 1 i 1 |
1 1 1 |
1 1 1 |
1 IHlscory given | Sol Hng Stem |ln Annals NY (Art (Pot Cleaner |ACAD SCIENCES | Ref l NY Ac a
KBlock Jams (Vol 329 (1979) |of Sc Syrep 1 1974) p 53 j page 190 In 1 1974
1
|Paper by
(Also Block
1 |B R CottIne ol | Jama 1.7.74
1
JOSH A
Ip 53
( i I Pot Cleaner l(Cf Block)
( t
|Ref 1 | Also Block (JAMA 1.7.74
IP 53
1
1 (Pot Cleaner |Louisville
1 (Cf Block) (Courier l | Journal 1 (02-09-80
(Ref 1 | Also Block
1 | Pot Cleaner KCf Block)
(Ref ( (Also Block
1 1 (Pot Cleaner ((Cf Block)
|Ref I |Also Block
1
1 | US Air Force
(Ref L +
Pot Cleaner (Cf Slock)
Loulev tile Times 23.7 . Retired Apr 1974 Also block
07
Diaries
03.05.22 UCC
T Smart
S Charle 27.08.44 ston
00.00.68
06.05.20 Goodyear Niagara
07.10.46 00.08.61
45
23.03.68 15 29.08.61
GENC 008356
Paj?e
USA Sheet L
ICl CKEH
b POLYHERS
LIVER Angl OHarroma Caiu-H - (Review Date: 1 Jan 19ft 9)
10
UK system of dates DAY - MONTH - YEAR
12 13
- LANGiOCAStS,l 15
COUNTRY AND REFERENCE NO
NAME OR INITIALS
DATE OF SIXTH
COMPANY
FACTORY
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
ACE AT DIAGNOSIS
YEARS OF EXPOSURE TO
DIAGNOSIS
YEARS OF EXPOSURE
DATE OF DEATH
HISTOLOGICAL CONFIRMATION
ESTIMATED EXPOSURE
LEVEL
OCCUPATION
OTHER CAREER HIGHLIGHTS
OTHER COMMENTS
Raymond GettleFi nger?
06.il.31
Louis ville
26.05.45 01.03.74
29 24 II.03.75
16.08.13
Goodyear Niagara
JL
12.06.51 00.05.68
55
17 10.05.68
11
27.05.09 Goodyear Ni agara
14.10.46 00.03.70
23 23 16.03.70
12 Francis A 17.11.18 Bactman
Pottstown 13.07.49 02.05.69
50
20
19 02.05.69
Pa
13
Richard
01.12.21 UCC
S Charle 11.12.42 00.05.74
52
32
26 07.04.74
Edward
ston
Clendenln
14
15
2000 ppa
Ref 1 has wrong figui re first exposure. Louisville Tines 29.10.74, 12.3.75. 10.3.76
Ref
High
10 yrs
10 yrs as
Utility 6
reactor op. Service op.
(not cleaner Bagger
- separate Dryer op.
crew cleaned Stripping op.
autoclaves) 3 yrs prior
service In
tyre plant
Ref 1 + 1ei of 26 Aprl J 9 78 from Russell A J to J T Seat of MCA
2000 ppn
Charleston Dally Hail 21.7.75
Never dlag nosed as a iosarcoma . liver. Inf * at Ion givei lettec 22 f 1984 from J A Salg.
Accountant ASL - No l"
denoe of V<
e xptis u re.
GENC 008357
Page
USA Sheet 3
ICt CHEMCa
POLYMERS
LIVER Angiosarcoma Canes - (Review Date: 1 Jan 1989)
10
UK System of dates DAY - MONTH - YEAR
UPX/A
LANCIOCASES,2
12 14
J6
COUNTRY AND REFERENCE NO
NAME OR INITIALS
DATE OF BIRTH
COMPANY
FACTORY
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
ACE AT DIAGNOSIS
YEARS OF EXPOSURE TO
DIAGNOSIS
YEARS OF EXPOSURE
DATE OF DEATH
HISTOLOGICAL CONFIRMATION
ESTIMATED EXPOSURE
LEVEL
OCCUPATION
OTHER CAREER HIGHLIGHTS
| | |
OTHER COMMENTS
James Hova rd
04.11.27
Lou la ville
08*05.50 00.00.69
41
19
27.03.69
Yes
1951-4 VCH polymerlsatlon
I
Froa 1954
t ITable 4 In
onwards in |Wagoner
Aray and otherfTestlaony to
service.
(US Senate
46-50 Army ^Confirmed In
|H N Johnson
111r 07.08.7e
17 Peerenboom 06.05.31
Louis ville
23.06.55 11.10.74
Yea 19 19 16.10.80 on 11.10.74
but no poat-aortea 16.10.80
I IDr H N Johns (letter of 124.2.61 con|firmed deatl
(6 years aft< (diagnosis
Charile Arthur
22.04.28 BFG
Avon Lake 15.09.54 00.00.75
46
21
(3 02.11.75
19
Virgil
00.00.15
Christian
S Charle 00,00.43 19.06.75
60
32
32 06.04.76
ston '''
13 yrs
Navy
autocleaner
6 yra on
Estol
Tyre Store
piastlclser
& Carboeet
operation
2000 ppa
| Continued l' |M N Johnson Utr 07.08.7: lAlso Rolling (Stone nag. I I 5.01.76
I______________ t (Wi11laras por (Sun Gazette (21 June 197 (Charleston |Dally Hall (21.7.75
20
31.06.17 Goodyear Niagara
00.00.55 30.01.76
21
Chester
02,09.09
Hinkle
S Charle 00.12.46 ston
Early 77
67
2) 18 30.01.76 30 22 02.01.77
I IN10SH lette lof 25.10.79 I___________
|28 yrs with (UCC at SC |RetIred (News releat 123.2.77 I
GEHC 008353
Page
USA Sheet 4
28
1C1 CHEMICALS 6 POLYMERS LIVER Angiosarcoma Cases - (Review Date: L Jan 1969)
UK system of dates DAY - MONTH - YEAR
WFX/ASL_2 - LANCIOCASES, 3
1 1
1
l
COUNTRY AND 1
REFERENCE (
NO 1
1
USA
1
1
21
name or
INITIALS
I 1 l
|
1
1
t
i 31
1 1 DATE OF 1 BIRTH | 1
[
4 COMPANY
i 1i
1 3| 6
i
7
1
8t
9
i 1i
if
FIRST VC t DATE OF | AGE AT
YEARS OF
i FACTORY | EXPOSURE i DIAGNOSIS 1 DIAGNOSIS i EXPOSURE TO
i1
DIAGNOSIS
ti
i
)
i 1i
10 1 JJ
)
12
1 13 ( 14 1 J5 f
1
YEARS OF | DATE OF 1 HISTOLOGICAL | ESTIMATED
|
EXPOSURE 1 DEATH | CONFIRMATION | EXPOSURE | OCCUPATION 1
J LEVEL
|
i
OTHER CAREER HIGHLIGHTS
1 (
(6
OTHER COMMENTS
22
23 24
(25)
\ \ i 1 i i i 1 1 J 1 i I I I I i i I i i
i
i !
|Charles | Edva rd
IMoore
i
i 1 i i i 1
1 i ) i 1
i i i 1 \
J
1 1
|02.10.23 ( BFC
1i i|
|Lou Is(vllle
| 11.07.47 00.01.76
fi
1 i i
52
i i
ii
ii
1i
ii
i1
i(
1i i|
ii l
1i
iii
i| i|
i1 ii
11
1
1i
)
1|
t|
1J i1 1| iJ
|i t
100.00.23 Great
1 | American 1 | Chemical
( Company
i |117.05.1? UCC 1i
i
i
i
| tFitchburg) 06.09.58 i 06.04.73
|Kaes.
|
i
i
|S Chariest
| aton J
F5T5
i i 27.05.77
i
i 1 t 1 i 1
)i
i i
i I
t
50 60
i i i
i i i
1t
1|
i11 ii1
1i J|
ii1 i
1i 1| 1|
1|
ii 1
ii i ii
1i
i ti
1i
t|
r|
e1 i1 ii1
i| i|
i1i ri1
ii
i it
ii
i ii
ii
i ii
i|
1i
i|
11
| Removal from reg ister confi nned In R Kaminski letter of 5 November
ij
i|I
j j_______________
i. j_______________
29
15 38
1980
28 104.12.76 |
Yes
14 106.04.73 1
Yes
| LouLsvi 1 le |Times 26.1.76 |aald he was (the 10th AS |vlctlm at IBells Lane of |whom 8 had Idled by (26.1.76 (In his letter |of 16.09.81 (Or H N Johnson (confirms this |is the lease described |by Dannaher ITamburro 6 Yam jin Feb I960 |Am J Medicine
|Vol 70 p280
24? (N10SH (says 26)
i
i,
12?.05.77
i|Cholangio| sarcoma
|(R Kaminski
| Medium to
|hlgh for )24 yrB
t, | 1941-65 non- 11937-39 was
Isolvent
|off and on
|Jvinyi reeln labourer
|N N Wheeler
(letter of
| *8.8.77 to
1 26/2/79)
(unit and
|1939-4l may (J Stafford
(dispersion |have been
Iglves detal1s
(vinyl resins |exposed as
|Rose Kaminski
(unit first (reactor
lletter of
(aa fitter Icleaner
126/2/79
Ihelper, then (1943 became |R Kaminski
| shift
Ishift fitter J(5 Nov 1980)
lutillty man J1946 became (suggests that
lahlft utility SHIOSH will
Jman
Iretafn on
(26.04.65
(register since
(employment was|this neoplasm
|termlnated
(may be assocl-
|ated with ASL.
| R N Wheel er
lletter of
120/2/79 and
(Rose Kaminski
(letters of
J_______ J___________ j_______________
t i
(26/2/79 and 15/li/HO
i
Page
29
USA Sheet 5
JCI CHEMICALS 4 POLYMERS LIVER Angiosarcoma Cases - (Review Date; l Jan 1989)
UK system of dates DAY - MONTH - YEAR
WPX/ASL_2 - LANG10CASES,4 *
i
12
t3 i
i
COUNTRY AND | HAKE OR | DATE OF i
REFERENCE | INITIALS t BIRTH i
NO i
USA
i
4 COMPANY
ii
1
15t6 t 7
11
1
1 1 FIRST VC 1 DATE OF
| FACTORY 1 EXPOSURE 1 DIAGNOSIS
ii ii
1 1
26 |John Berry 107.07.23 i BFC i
i i i
i
i
i
27 1J L
i 111,05.16 i UCC
|Forrest
i
i
i i
1 1 Louis-
1 | 03.10.97
00.00,77
jvllle
i i i
|
i i t
1 (up to 2 years
1 after 1 death)
ii
1
ii
1
ii
1
11
J
11
1
it
1
ii
1
ii
1
ii
1
ii
1
IS Ctiarle-| 01.07.91 1 30.11.78
I ston |
1
ii
1
11
11
ii
1
ii
1
i
it
1
28
111.09.17 i UCC
|S C3iarle-1 00.OB.9) 1 03.11.78
i
| aton |
1
29 '
112.10.07
i t UCC
i
t
ii
1
| S C2iacle-l 00.05.42 1 00.01.80
| aton |
ii
30 | WVN
ii
1
122.07.22 i Tenneco 1 Flemington 11.06.69 1 30.12.80
Chemicals i
i
1
t
1!
I
i 1t
11
i
11
1
11
1t
1
31
108.11.23 i UCC
|S Charle-t 12.05.96 1 01.08.81
i
J ston |
1
i
ti
1
t
it
1
i ii
i
ii
1
i
ii
1
i
ii
1
ti
1
i
ii
1
i
ii
1
1
i
ii
1
i
ii
1
i
ii
(
8
ACE AT DIAGNOSIS
1 9 t 10 ( 11
YEARS OF
1 | YEARS OF | DATE OF
EXPOSURE TO j EXPOSURE | DEATH
DIAGNOSIS t
1
52 (death)
62 61 72 58 57
)
26 (death)
37
34 36 17
35
1 18 111.02.75 1 1 1 t t 1 1 1 1 i t i 1
i I 20 125.11.78 HNIOSH |aays 27 land C |Dally Hail | 125)
1
( | 33 103.11.78
1
i 1 18 101.03.00 1 1 i 1 15 130.12.80 i i l 1 J i
i 1 13 102.09.82
i i t i J i i 1 i J 1
i i
i
ii 12 1 S3 1 19 i
1 HISTOLOGICAL ! ESTIMATED |
1
CONFIRMATION | EXPOSURE | OCCUPATION
| LEVEL {
[(
i
15
OTHER CAREER HIGHLIGHTS
16
OTHER COMMENTS
Yes
Yea Yes Yea Yea Yes
{Exposed in (Various jobs|
R Kaminski
(some degreefln PVC
|
letter of
|to 22
Jplants from
26/2/79 and
|chemicals Icold room to|
Prof. Tambuj
|but main Ipaste
letter of
(exposure |recovery to
9/1/79
|vas to VCM 1 PVC charging
(probably (operator to
Ihlgh
(paste
1 1 charging. | 1 |111 August
I
11965.
1
1 (Terminated
1 (employment
1 |Jan 1966
1
High |Operator to (Exposure In
R N Wheeler
1
|10.10.76
|bulk and
ltr of 4 Jar
||
|diaperslon PVCf J979 and
1| |1 11
11
(manufacture
ti 1t |1 |1
1J |t
i 1
11
1
1t
i
{6 - Unknown IHalntenance |
Charleston Dally Hal 1 30,11*78 and k Kaminski 26/2/79 R Kaminski letter of 6/9/79 R Kaminski Letters of 19th June 19 4 5th Nov t9
|9 - Minimal (Mechanic
|
|
16 yrs
|
i |Elsewhere |
i
lit yrs
|
i |Boiler house|
|
(Operator
|
i 19 yrs IHlgh (But (Chemical
| |From 1959 to
Dr Dacey
|not as high (Operator In (1976 Aliphatic letter
|as reactor Icharge
(Chemicals
16.10.81 and
(cleaner
I reactor
(operator and R N Wheeler
|would
|
(from July 1976 letter of
(experience) | (Worked as |
|to date (Foreman
9.11.81. Also Dr Dace}
| labourer |
(Aliphatic
tecter of
1f root
|
|June 1941 f
(Chemical (Operation
07.03.83 re date of deatl
|to May 1946 1
land may
1
|have
!
(cleaned
(
|reactors In 1
1 1 1 1 1
6663ifi
60)'-
Page
USA Sheet 6
30
ICl CHEMICALS & POLYMERS LIVER Angiosarcoma Cases - (Review Dace: 1 Jan 1989)
UK ayscetn of daces DAY - MONTH - YEAR
VPX/ASL_2 - LANCIOCASES '5
COUNTRY AND REFERENCE NO
NAME OR INITIALS
DATE OF | BIRTH | COMPANY
FACTORY
FIRST VC | DATE OF EXPOSURE I DIAGNOSIS
8
ACE AT DIACNOSIS
9
YEARS OF EXPOSURE TO
DIAGNOSIS
1 10 1 Ji
1 1 YEARS OF ( EXPOSURE |
DATE OF DEATH
t
12 i n t 14 i i
HISTOLOGICAL I ESTIMATED CONFIRMATION | EXPOSURE | OCCUPATION
j LEVEL
15 |
E6
OTHER CAREER HIGHLIGHTS
| |
OTIIKH COMMENTS
l 32 C W Giroux 22-02-06 | Monsanto Springfield 15-10-51 | 00-07-79
I Hass I
I I t
33 S Ferguson 08-10-27 J BFC
Jnr
I
LouLsvlile 09-09-54 11-05-82
71 26 1
1 1 1 1 1
1 1 1 1 1 1 (
1 1 1 54 1 28
1
34 Hr Byrun 29-01-34 | BFG 1
Louisville 1955
I ( 03-11-82
I
!
48 1 27 1 1
1
1
I X1
I1 1
35
09-03-12 | UCC
S Charle 23-07-44 | 18-07-83 |
71
1
39
( ston
II
1
I1 1
____________ 1
1
I(
36
27-06-32 |The General Ashtabula 11-06-56 121-08-83
50 1
27
JTire and
11
|Rubber Co
1
1
11
I i1 t1
1
f
1
1
1
1
14 117-05-80 An autopsy |The death (1940-1951
| Information
(in PVC t
vas done and certificate!Various Jobs|
Igiven In
autoclave I
immediate
Igave
(in polyner
lletter of 2
are*)
1
cause of
1 Hr Giroux1 (manufacture
|February H
death given juaual
|BUTVAR
(from Dr
1 as (occupation | LtlSTREX
lUalter C
1 "Angiosarcoma* ( as "kettle)1951-1964
|Barnes of
1
(operator* |Various .joba|
|Monsanto
1
|ln (in and
|Spring!lc
1
("chealcals |around PVC
|Dr A Mum
1 | ''
|industry". lautoclavea i 11964-1973
IHonaanto |Europe.
1 i |Varloua
1 i |cLerlcal
1 1 fjoba In PVC
1 | 1 polymerisation
1 i Ifacility/
1 i |Retlred
1 i 101-03-73.
1 28 |Alive
Yes
|
fHult(pie
(Prof Tar
i
i | Jobs
lletter <
i
1 |Including
|J 2 Aug
1
| | Poly
|Dr H N Johr
1
| (Operator +
lletter of
i
i f Polycleaner.
|28 Feb 1983
|1
10 104.08.83 | Yes
| Poly
|1965 left BFG | Dr M N Johr
1 | |Operator + ) to become a (letter of
1
i
| Autoclave |Clergyman.
|3 Nov 1982,
i
i iClesner
|28 Feb 1982
i 11955-65.
land 9 Aug
ii
11984.
i
1
14 |18-07-83 Yes
(High from
|Dr Dacey
1 1|
(1944 to (1955.
lletter of |5 Sept L93
1 |Medium fron|
i 11955-1958
1
27 fAlive
Yes
(Moderate 11956-56
|R W Laundrl
i
J Jlabourer
(letter of
t
( 11956-57
| 12 Sept L9fe
\ 11
i Iprod helper 1 11957-70
Ispotted at Imedlca1
i
(operator
|May 1983.
i
| 1970-75
|Tes t Ing
1
|e lect ric tan
|commenced
1
| 1975-present
J May 1983
f |operat or
1
6ENC 008361
Page
USA Sheet 7
Cl CHEMICALS A POLYMERS LIVER Anglosarcoma Cases - (Review Date: l January 1989)
WPX/ASL2 - LANG lUCASKS ,*
UK system of dates DAY - MONTH - YEAR
l
COUNTRY AND REFERENCE NO
USA
37
38
39
1i
12
1
11
|J
INAME OR ]
|INITIALS 1
i 31
1
DATE OF| BIRTH |
4 COMPANY
1 1
l (Mr J |Payton
| |
ii ii ii (29.08.29)
)t | t
8FG
1 1 | l
1 1 1 (JWB
1 I |
ii ii ii ii ii ii ii 128.08.221Air | (Products
11 ||
1 11 11 t1 1l 1 ii 1 11 | 11 11|
1 ii 111 11 |l | J Metnlce I 27.06.181 Pantasote |)
|I
1)
||
||
||
(1 (| ||
||
(I fj (i
||
||
|| |1 || ||
|
11
1ii
1 l5
1 1 i ( FACTORY
i i i |Louis-. Ivllle
1 1
i i J t 1 1 1 |Calvert ICity
1 1 1 1 J 1 1 1 1 1 1 1 1 1 |Passaic
1 1 1 | I I
i 1 |
(
) 1 I ) ) I I 1
| |
i i
1 16 1 t (FIRST VC |EXPOSURE
i i t 1 1953
1 | 1 1 1 1 1 1 1 I (00.02.63
t 1 1 1 1 1 i 1 1 i t i 1
( | 1960 1 i I ( I I
i i 1 l i i
j I I i i i i 1
i i
i |7
1 8 19
i 10 1 Ll
1 1
1 13 1 14
f 15 1
16
1
i (DATS OF
(AGE AT
1 |YEARS OF
|EXPOSURE
11
1 IHISTOYEARS 0F| DATE OF |LOGICAL (ESTIMATED!
|OTHER
(DIAGNOSIS! DIAGNOSIS(TO
|EXPOSURE) DEATH 1CONFIRM- |EXPOSURE 1 OCCUPATION |CAREER
|
OTHER COMMENTS
i
|DIAGNOSIS)
1
|ATION (LEVEL
|HIGHLIGHTS!
i 1 11 1
11
i 106.08.84
1 ( 1 1 1 t 1 1
i 34 1 31
1 1 1 1 1 1 1 1
11
22 106.08.64 | Yes I High IWorked
11
|regularly
11
| In PVC area|
1i
|In the
11
learly days
i1
|vas a
11
| reactor
11
Icleaner
11
| 1953-73.
(Information given In letter 09.08.84 |from Dr H N Johnson
1 1 (19.01.84
1 1 6 L | 20
11
11 20 |28.10.83 ( Yes 1 High |Nornal
IThrombo cytopenla and leukopenia since Islnce 1976. Gold treatment for arthrltl
i
1
1 1 11963-1982iprogressIon |
11976. Under Dr's care about 6 months
i
1
i1
(fro* helper!
Ibefore death, had passed standard physic
1
1
11
(to senior
(examination 3 months earlier. J Barr
l
1
11
(operator .
llecters of 22.(0.84 and 23.OJ.65.
1 1 1 1 |cleaned
t i 1 1 |reactors,
t i i 1 (stripping
) 1 1 1 (and
1 1 1 1 (recovery
( i 1 1 (areas as
i i 1 1 |well as
) 1 i i Icharglng
i i 1 i loperator.
1 (March ) 1984
i I I 1 ( i 1 1 1 i i i 1 1 1 1 1 1
|
1
i
i 1 63 1 24 1 i 1 1 1 1 i i 1 i i i 1 1 1 1 1 1 i
!
i i
1j i1 23 (29.06.84 I Yea | Low (29.09.60 - |Worked
|Never In hospital for any chronic or |acute medical problems. Death certlflcai
1i
(May 66
|before
latates cause of death cardlo-pulmonary
ii
|Vinyl
11960
larrest secondary to angiosarcoma of
1i
]Fabrication (with US |1Iver.
1J
]Plant
| Air
(Letter of 15.07.86 from John E Ertel
1
1
1 High (May 66 - |Force,
(of Pantasote with letter of 24.02.86
11
(Aug 70
|United
(from Dr Auerbach, Pathologist.
1J
(Utility
|Wool
11 11
(Resin (Operator
I Dyers land
1i
|(Inc Jul 66 |Okanite
11
1- Sep 67
11
| Reactor
i1
(Operator) (
l 1 | Low (Sep 70-82
ft
| Monomer
!1
|0perator
f 1 | Low | 1982-83
\1
(Mi 11
i1
11
(Operator,
|Calendar
i1
(Shop, until
11
j(
f ret 1rement
t
*
Page
32
USA Sheet 0
ICI CHEMICALS 6 POLYMERS LIVER Angiosarcoma Cases - (Review Date: 1 January 1989}
WPX/ASL2 - LANClOCASt-
UK system of daces DAY - MONTH - YEAR
l
COUNTRY AND REFERENCE NO
USA
40
41
1 12 I
31
4
|NAME OR | INITIALS
1 1
1 |P P |Gilmer
DATE 0F| BIRTH |
26.10. 1M
COMPANY BFG
1 \
iii IR Buckley 2.02.131 Goodyear
1 1
I 15
1 1
i 1 FACTORY
i i 1 |LouisIvLile | | 1
i ( 1 |Niagara (Falls ( 1 f | | | |
1 1
i 16
1 | |FIRST VC 1 EXPOSURE
1
1 1 122.05.42
i 1 | 1
i i 1 | 1949 I 1 l I I I | |
1 1
11 | 7 1 8 19
I 1 JO
LL
111 1 |YEARS OF
IDATE OP 1 ACE AT (EXPOSURE
IDIACNOS1S|D1AGMOSISITO
i i |YEARS OF (EXPOSURE
DATE OF DEATH
t |DIAGNOSISI
)11
i1 1
I 1967 i 72
1
45 1 34
03.01.87
1i1
ii1
lIi
11 i
i1 1
i1 1
11 1 1 1987 1 72 l 36 1 27 20.08.87
1ii
t11
11(
11 )
11 1
1( 1
1( 1
Ii1
(tl
1 i1
1i
1
1
1 13 1 14
1 15 1
16
11 1HIST0- 1
1
(LOGICAL JESTIMATED!
(OTHER
|CONFIRM- (EXPOSURE (OCCUPATION |CAREER
t
OTHER COMMENTS
IATION |LEVEL
i
|HIGHLICHTS|
11
i
11
* | Yes 1 High | Chemical
|Letter from Dr Diets, BFG,
1 |1942-1974SWorkec
ii
(1942-45
i | Low |
1 |1975-19761 Foreman
i(
(1945-76
110.3.87
i 1 J__________
t | Yes
i1 High 11949-65
| Retired |Letters from Prof Tamburro
i1
|Chemical Op/ 1977
/University of Louisville, J 967
1|
|Shift Sup/ 1 (Age 62) land Dr C A Johnson, Coodyear, 1988
1|
(Foreman,
1
l'
(PVC Resin
i|
|Production
t | Med Um |(965-77
(i
|NF Plant
1 |[Left PVC area for 6 months
( I In 19651
J J_________ !__________
genc 003363
Page 33 YUGOSLAVIA
ICl CHEMICALS 6 POLYMERS LIVER Angiosarcoma Cases - (Review Date: l Jan 1989)
UTPX/ASL - LANCLOCAStS , 33
J
1 2 | 3i
4 I 5 | 6 | 7 1 8 1 9,
10 I n
1 12
1 13
| 14
1 13 1
r i
1 i
_IL
COUNTRY AMD (NAME OR J DATE OF|
t !1
1 . ...
1
1 I1 1
i i |1 1
(YEARS OF
1 JHISTO-
|
| | |j FIRST VCJDATE OP AGE AT |EXPOSURE YEARS OF) DATE OF )LOGICAL ESTIMATED)
1 1
|OTHER
1 1 |
REFERENCE
i | (|INITIALS! BIRTH
COMPANY | FACTORY EXPOSUREj DIAGNOSIS!DI AGNOS IS TO
EXPOSURE) DEATH 1C0NFIRM-IEXPOSURE (OCCUPATION (CAREER
(
i i i |HO i i i
ii
lDIAGNOSIS!
ATION 1LEVEL j
|HIGHLIGHTS)
JL
i
i
L._...................1_!
JL
i
11
f
J1
16 OTHER COMMENTS
YUGOSLAVIA
05.04.14 Jugo VlnlL
Spilt
00.00.53 08.04.73
59
20 20 08.04.73
SARIC et al paper Env Health Perspective VoL L7. pp 189-192 J 9 76
02
15.11.31 Jugo
Split
00.00.50 12.07.73
23 18 12.07.73
Vinll
VCM Production
*ln his letter of 3 Oct 1978, Dr Splrtaa of NIOSK changed the status of Case 02 to VCM production employee. Dr Splrtaa also notified a new Case 03 also a VCM production worker.
03
21.12.31 Jugo
Split
04.06.54 1.Ot.76
45
22 22 11.01.76
Vinll
VCM Production
04
11.06.30 Jugo
Split
15.12.58 03.09.78
Vlnil
JS 03.09.78
Rose Kaminski letter of J9 June 1980 and tARC letter of l April 1982
f l
SBC 00 8364
_____ 1
Page
34
Incidence of ASL Cases Per Annum
TABLE
1
(Review Date - 1 Jan 1989)
By date of death
1955 ................................................................................................ 1 60
7 ................................................................................................ 1
8 ............................................................................. 0
90 1960 ................................................................................................ 0
1 ................................................................................................ 1
21
3 ................................................................................................ 0 4 ................................................................................................ 2
5 ................................................................................................ 0
6 ............................................................................. 0
7 ................................................................................................ 1
8 ................................................................................................ 5
9 ................................................................................................ 3
1970 ................................................................................................ 2 1 ................................................................................................ 3
2 ................................................................................................ 5
3 ................................................................................................ 8 4 ................................................................................................ 5
5 ................................................................................................. 11
6 ............................................................. ... ........................................................................... 11
7 ................................................................................................ 9
8 ............................... .............................................10
95
1980 ................................................................................................. 10
1 ................................................................................................ 5
2 ................................................................................................ 3
3 ................................................................................................. 10
4 ................................................................................................ 7
5 ................................................................................................ 6
6 ................................................................................................ 5 7 ................................................................................................ 3
8 ......................................................................................................................................... jJ*
Total
137
N.B. 1 Does not include Italian 01 but does include German 03.
2 The 1977 total includes US case 24 which is a Cholangiosarcoma.
3 Does not include the following who are still alive, so far as known: Frl5, 22, 23 & 24, G31 & 32, US33
QENC 008365
Page
35
Distribution of ASL Cases by Country
TABLE2
review uate - i jan
USA W Germany France UK Canada Sweden Italy Yugoslavia Japan Czechoslovakia Belgium Norway
38 ** * 31 ** *** 25 *** 15 13
5 **** 6* 4 ***** 3
2
2 1
Total
145
* Omit ItOl - atypical case of PVC bag extruder. ** Includes G03 aerosol can filler.
*** Includes case US 24 which was diagnosed as Cholangiosarcoma; & Frl5, 22, 23 & 24, G31 & 32, US33 & 36, who are still alive, so far as known.
**** Includes one monomer worker. ***** Includes two monomer workers.
Western Europe North America Rest of World
85 51
9
Total 145
WPX/ASL2 - LANGIOCASES,10
GENC 003366
Page 36
Pattern of ASL Cases by Factory
TABLE 3
(Review Date - 1 Jan 1989)
(a) W Europe
Of the 85 cases in W Europe, 73 have occurred in clusters at 12 factories. Of the 31 German
cases, 28 have occurred in clusters at 4 factories.
ASL Cases
Dynamit, Troisdorf, Germany BP, Barry, UK Wacker, Burghausen, Germany Atochem (formerly Chloe Chimie, formerly RP), St Fons, France Atochem (formerly PCUK) Brignoud, France Kemanord, Sundsvall, Sweden CWH, Marl, Germany ICI, Hillhouse, UK Solvay, Tavaux, France Lonza, Waldshut, Germany Solvay, Jemeppe, Belgium Atochem, St Auban, France
12 11
9 9 8 5 4 4 4 3 2 _2 73
NB: There are 32 pre 1962 PVC plants in W Europe; 19 of these have had ASL cases (Ref Table 8)
(b) N America Of the 51 cases in N America, 42 have occurred at four factories out of a total of 55 factories. Tin N America 42 plants have not had ASL cases. ASL Cases
BFG, Louisville, US BFG, Shawinigan, Canada UCC, S Charleston, US Goodyear, Niagara Falls, US
15 12
10 _5 42
NB: There are 29 pre 1962 PVC plants in N America; 13 of these have had ASL cases (Ref Tables 9 & 10)
(c) Rest of World The 9 ASL cases are believed to be in one cluster of 4 and two clusters of 2 cases.
WPX/ASL2 - LANGIOCASES,11
GENC 00836?
^^'age 3 7
TABLE 4A
(Review Date - 1 Jan 1989)
Latency Periods (Years from first Exposure to Diagnosis)
W Europe
Count ry Belgium
No of Cases 2
Total Years 35
Average 17.5
France
25 689 27.56 *
N America
Germany Italy Norway Sweden UK
31 632 20.38 *
6 127 21.16
1 22 22
5 122 24.5 15 350 23.33 * 85 1977 23.25 W Europe Average
Rest of World
US Canada
38 993 26.13 *
13 314 24.15 * 5_L 1307 25.62 N America Average
Summary
Czechoslovakia s~`
Japan
Yugoslavia
2
3
4 9
30 15.0
59 19.66
85 21.2 174 19.33 Rest of World Average
W Europe
85 1977 23.25
N America
51
1307
25.62
Rest of World
9 145
174 3458
19.33 23.84 * World Average
* Of the countries with * 10 cases, France, USA & Canada have an average latency period above world average* Germany & U!
below world average,
'
T TT> V / a rvr o
t
GENC 003368
ge 38 DISTRIBUTION OF LATENCY PERIODS TABLE___ 4B
(Review Date - 1 Jan 1989)
i! i 1 1 1 11
11 i 1 ! f 1 1
1 0-9 yrs I 10- 14 yrs | 15-19 yrs | 20-24 yrs | 25-29 yrs ] 30-34 yrs I 35+ yrs |
11 f 1 1 1 11
11 1 1 1 1 11
11 1 1 I I 1 1
| Belgium j Canada
1 1
1 1 2i 1 1 1 1
1
1
f
1
i
11
11
I 3I 11
1
5|
2I
11
2I
1 1 5 1 11
| Czechoslovakia 1
1 1| 11
i
1
11
1 1 1 1 1 11
| France
1
I
1|
41
31
9i
31
5|
| Germany
1
)
-1 1
1 5|
1 9I
10*
1 )
i 5|
1 2. 1
i F 11 )i Il )1
1 i f
F
| Italy
i 1 21 21 2I 1 1 11 11 1 1 I J 1
| Japan
1i
1 1 1 2i
i
t!
1 ii 11 1 i I 1 1
| Norway
1
i
!
1 1|
1
11
11 I1 j
1 11
J Sweden | UK
1i
tl 1 1i
1 21
i 2I 1 1
111I1
1 5f
1|
5I
31
!
1I 1
1
S USA
1i 1 1 I 1 11
1
i
2I
71
91
8 I
5i
7|
1i
1
1
i
i
tI
I
| Yugoslavia
1
i
1
1 4I
i
1i
1i 1 1 I i 1i
| TOTAL
1i 11i
1
12 |
1 33 1
1
37 |
i 33 I
1i 15 1 14 |
1i 1 1
1 1t
Total
2 13
2 25 31
6
3 1 5 15 38 4
145
11 I Average | I Latency ! | Period | |(Table 4A)|
Ii
1 17.5 1 11
1 24.15 I
11
1 15.0 t tI 1 1 1 27*56 I
1i 1 20*38 f Ii
1 21.16 I 1j
1 19.66 l !|
1 22
1
! |
1 24.5 I if 11
i 23.33 I
11
1
!
1 26.13 t
li
i 21.2 I
11 11 1 23.84 |
11
* Includes G 03 aerosol can filler
WPX/ASL2 - LANGIOCASES,13
6EHC 00836?
Page 39 (Review date 1 January 1989)
TABLE 4C
LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE
px POSSIBLE |
YEAR OF . 1 LATENCY PERIOD
| ARITHMETIC MEAN
1
KTENCY PERIOD | FIRST EXPOSURE 1 (NO OF YEARS)
| OF LATENCY PERIODS 1
11
11
I 49 1 48 l 47
I 46
r 45
1 1939 | 1940 |1 12 13 14
1 38*
|
11
1 37,21,37,41
|
1 32,38,45
|
i 38,14,32,42,45***
|
1 28,11,24,20,24,34,39,1
1 289 = 36.12 1
81
1 1 886 = 28.58 1
1
1 44***
| 31
1
1 5 1 27,22,28,29,37 |
1
1 6 1 21,29,31,26,28,15,23,1
1
1
1 30,35
|
1
41 | 7 1 29,24,29,28 40 1 8 1 28,24,34
1 9 1 30,26,20,38
|1
|I | 559 = 25.41 1
| 1950
1 26,22,31,19,23,14,33 |
22
1
|
1
1 19,28,17,28,34,29
|
1
36 1 2 1 21**,15
|
1
35 1 3 1 25,22,23,22,20,31,22,1
1
1
1 32***
|
1
1 4 1 21,21,25,25,21,28***,!
1
1 1 22
| 849 = 22.94 1
1
5
I 22,23,24,14,19,21,27 |
37
1
iI
I 27*** 24,28,30***
|
1
1 6 1 21,12,27***,32 I
1
31 | 7 1 19,17,15,13,16,28,30 |
1
30 1 8 1 18,18,15,17,20,29***28
1
1 9 1 16,21,25,27
I 598 = 19.29 I
J
| 1960
1 13,18,21,25,24,25
|
31
i
1 | 1 1 15,16,16,16,19,19,12 |
1
26 1 2 1 13,18,17,12,18,21,26 I
1
25 1 3 1 16,17,20,21,25 I
1
1 4 1 16,17
| 246 1= 17.57 1
| 5 1 11,19,20
I 14
1
1 6 1 9,18,21
|
I
21 1 7 1 16
1
1
20 I 8 1 18
1 9 1 13
I 1970
1
|1
| 31 S= 15.5 1
12
1 VIOLA
|1\
11
16 1 2 1
15 1 3 1
14 | TOTAL
1 1 145 CASES
11
1 1 MALTONI 1 1 GOODRICH | 3458 =S 23.84 1
11
1 145
1
* Cholangiosarcoma ** Aerosol can filler fc** The following are still alive, so far as known Frl5, 22, 23 & 24, G31 and 32,
US33 and 36
GENC 008370
TABLE 4D
Page 40 (Review date 1 January 1989)
LATENCY PERIODS OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL
LOCATION
'
~ MAX POSSIBLE I
YEAR OF
|
LATENCY PERIOD 1 FIRST EXPOSURE |
LATENCY PERIODS IN
WESTERN EUROPE |
NORTH AMERICA
11
49 1 48 I 47 1
1939 1940
1
1 1
1 37,41
| 38* 1 21,37
46 1 45 1
1
1
1
21
3 | 38,45*** 4 | 28,44*** 5 1 27 6 | 21,29,31,33
| 32,38,45 | 14,32,42 | 11,24,20,24,34,39 | 22,28,29,37 | 26,28,15,23,30,35
41 1
7 | 29
| 24,29,28'
40 1
1
8 | 28,34 9 | 30,26
1 24 | 20,38
1
1950
| 26,22,31
1 19
1
1 | 19,28,34,29,
| 17,28
36 1 35 1
1
1
1
2 | 21**
1 13
3 | 25,22,22,32***
| 23,31
4 | 21,21,25,25
| 21,28***
5 | 22,23,24,27***24,28 | 14,19,21,27 1 30***
1 6 | 21,12,32 1 27***
31 1 30 1
1
1
7
8
9 1960
I 19,17,15,13,28 | 18,18,29***28 | 16,21,25,27, | 13,18,21,25,25
1 30 1 15
| 24
1
26 1 25 1
1
1
1 | 15,16,16,16,19,19 1 12
2 | 13,18,17,18,21,26 1 12
3 | 16,17,21,25
| 20
4 1 16
1 17
5 1 11,19
21 20
1 1 1 1
6 1 9,18,21 7 1 16 8 1 18 9 I 13
1 VIOLA 1970
11
1 1
:^
1 21
1 MALTONI 3
1
1 TOTAL CASES
1 85
1 51
1 ROW
1 1 1 1 1 1 1 1 1 1 1 1
1 23,14
1 1 1 22,20 1 22 1 1 1
1 16 1 17,20
1 1 1 1 1 1 1 20 1 1 1 1 1 1 1 1
19
* Cholangiosarcoma ** Aerosol can filler *** The following are still alive, so far as known Frl5 22, 23 & 24, G31 and 32,
US33 and 36
WPX/ASL2 - LANGIOCASES,15
GENC 0GS371
TABLE 4E
Page 41 (Review date 1 January 1989)
PLANT
1
| START | UP I DATE
1
Blouisville USA
1
| 1940? I
troisdorf
mv GERMANY
1
| 1954 i
shawinigan CANADA
1
1 1943 1(1941?)
1
BARRY
| 1948
UK
i
1
S CHARLESTON 1 1939?
USA
i
i
LATENCY PERIODS OF ASL CASES IN SPECIFIC PLANTS (10 OR MORE CASES)
12 ,14,15,19,19,20,24,27,28,28,28,29,29 31 ,45 12 ,13,16,16,18,19,19,21,23,25,28,29
11 ,12,14,21,22,23,24,24,26,28,42,37
9, 17,18,28,31,33,18,19,18,21,32
24 ,30,32,32,34,35,37,38,38,39,
1
NO OF |
AVERAGE
CASES | LATENCY PERIOD
1
| |
1
1
15 |
1
24.53 years|
1
12 |
1
19.91
|
1
12 |
1
23.66
|
I
11
1 1
22.18
|
1
10 |
1
33.99
|
1
h
X/ASL2 - LANGIOCASES,16
GNC 00837
Page 42
TABLE 4F
(Review date 1 January 1989)
LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OP FIRST EXPOSURE AND SPECIFIC PLANT (10 OR MORE CASES)
YEAR OF FIRST | LOUISVILLE |
EXPOSURE
| USA
|
1939
1
1
1940
1
1
TROISDORF W GERMANY
1 SHAWINIGAN |
I CANADA
1
I1
11
BARRY UK
11 21
1 1
1 21 1
1 1
31
1
4 I 20
1
5 1 28,29,27 1
61
1
7
I 29,28
1
8 | 24
i
1 14,42 1 11,24 1 22,37 I 26,28 1 24
1
1 1 1
I
1 1
9 1950
1
1
1 19
1
i i I 29
1 1 1
1
1 31,33 | 28
2 1 15
1
11
3 1 31 4 | 28
1
1 21,25
1 23
1
1 1
5
1 14,19
I 23,28
61
1 12
71
81
1 13
1
91
1
1 1
!
1 1
| 32
1 1 1
1960
1
1
11
11
I 16,16,19,19, I 12
1
2 1 12
31 41
1 18
1
1
I
1
1
1 18 1 17
1
51
61
71
81 91
1 1 1 1 1
1 I 19 1 1 9,18,21
11
1 | 18
11
1970
1
!
1
1 1
11 11
21
1
1
| S CHARLESTON | USA | 38
1
1 37 I 32,38 | 32 I 24,34,39
1
I 30,35
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
f
WPX/ASL2 - LANGIOCASES,17
GEHC 008373
Page 43 (Review date 1 January 1989)
TABLE 4G
START-UP DATE |LATENCY PERIOD OF ASL CASES |IN SPECIFIC PLANTS(4-9 CASES)
1933
! | 17,21,22,25,24,13,21,32,30
1
1939
1
| 21,28,29,37,38,27,41,34,44
1
1
1950
| 11,16,18,26,30,25,34,45
1
NO OF CASES
9
9
8
AVERAGE PERIOD 22.77 years 33.22 25.62
1945
t 16,19,27,29,31
5 24.4
1947 1950 1948 1953 1940
1
| 15,17,21,23,38
1 1
| 20,20,22,23
1 1
| 15,16,22,21
1
1
| 19,16,21,26 I
1
| 28,25,28,25
5 22.8 4 21.25 4 18.5 4 20.5 4 26.5
WPX/ASL2 - LANGIOCASES,18
GENC 008374
Page
TABLE 4H
LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (4-9 CASES)
YEAR OF
BURGHAUSEN
FIRST EXPOSURE W GERMANY
1939 1940
1
2
3 4 5
6
7
I I I I I i 1
1
I
1
I 1
1
| |
1
I
1
ST FONS FRANCE
37,41
38 44
29
28,34
1 1 1 1
1 1 1 1 1
BRIGNOUD FRANCE
1
1
1
{ 45 1
1
1 i 1
SUNDSVALL SWEDEN
27* 31 29
!
1
1 1
1
1
| 1 |
NIAGARA FALLS USA
1
1
1
!
1
1
1
15,23 |
1
SPLIT
MARL
YUGO W GERMANY
SLAVIA
11
1I
11
1
11
f1
11
11
1I
TAVAUX FRANCE
HILLHOUSE UK
1 1
!
1 1
1 28
1 1 1
25,32 21 22,24,30
17
23*
19
22 21
25
19 28 20
21
16 11
26 16,21
25
13
*Monomer worker
GENC 008375
TABLE 5
Annual Incidence of ASL Cases (Date of Death) by Geographical Area
1955 7
1961
2
4 7
8
9 1970
1
2
3 4 5
6
7
8
9 1980
1
2
1983 1984 1985 1986 1987 1988 TOTAL
11
| Western Europe 1 North America
1i
1 11
1 11
1 11
1 11
1 11
|1
1
1 15
|1
12
|1
11
|1
12
14 |1
11
14
13
16
16 16
|7
12
14 13 13
12
|5
1-
16
|5
14
0
|1
2
|7
13
|5
12
|5
1
14
11
1 t3
14
!
|
79* **
1
49**
Rest of World | Annual Total
|1 |1 |1 |1 1I2 |1 |` 5
13
12
13
|5
318 -| 5
1 1 11
2 1 11
I9
1 1 10
-|5
- f io
-|
5
13 1 io !7
116
|5
13
14 9 | 137
| Cumulative 1
| Total
| Key Events
11
I1
1
12
13
1 1
14
1
16
|7
1 1
1 12
1 15 1 17 ! 20
1 1
| Viola
1
i 25 I 33 1 38 | 49
1
| Maltoni | Goodrich
1
| 60
1
I 69 1 79 I 84
!
1
1
| 94
1
1 99 | 102
1 1
1 112
I 119
t
1
| 125 | 130
1 1
| 133
1
| 137
1
11
* Includes G03 aerosol can filler but omits It 01 bag extruder
** Does not include the following who are still alive, so far as known: Frl5 22, 23 & 24, G31 & 32, US33 & 36
6E!* 003
Page 46
TABLE 6
(Review date 1 January 1989)
ASL CASE NUMBERS BY YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING 11.0 1)
|_ KEY
1
| EVENTS 1
| WESTERN EUROPE
i
I NORTH AMERICA
11
| REST OF WORLD|
I 1 11
1
1 1955
I 1 Cl
11 11
1
17
1
| C2
1| 11
i8
i 11
19 1 1960
11 12
i
i
1 US8 | C3
11 i1 11
13 14 15
1
I US5
1
1
I Cz2
1
1
|
1
16
1 11
|Viola
17 I8 19 1 1970
11 12
1 El
1 G1 | Swl | G2 | Nl,Sw2,UKl,It2
1
| C4,C5,US4,US7,US10 | US12,US16
1 usu
1 C6,US2 1 C7
1 1 1 1 1 1
1 1 1 1 1 1
|Maltoni 1
3 | G3**
| C8,US1,US3,US23
| Yl,Y2,Czl
|Goodrich 1
4 | G4.G5.UK3
| C9.US13
1
1 5 | F2,F3,G6,G7,G8,It3
I US6,US9,US18,US26
1 Japl
1 6 | Bl,F4,F5,F6,F7,Sw3
I US19,US20,US22,
1 Jap2,Y3
1 7 I F8,F9,G10,Gll,G12,Sw4 1 8 | F10,F11,G9,G13,G15
| C10,US21,US24* I US27.US28
1
1 Y4
! I G16,G17
I
1
1 9 | F12,F13,UK4,UK5,G18
1
1
1 1980 | UK6, UK7,G19,Sw5,G20,G21US | US17, US29, US30.US32 1
1 1 1 It4,F14,UK8,G22,G23
I
1
1 2 | G26
| US31.C12
1
1 3 | UK09,It5,F17,B2,G24,G25,G30| US35, US34, US38
1
1 4 I UK10, F16, F18, G27,G29 | US37.US39
1
1 5 | UK11, UK12,F19,F20,G28
1 Jap3
1 6 | F21,UK13,It6,It7
| CU ''
1
17
| US40,US4I,C13
1
1 8 | F25,UK14,UK15,UK16 1 Total j 79***
1 1 49***
I
19
|
1
| t I |
I 1 1 1 1 1 1
|
1 1 1
|
1 1 11
* Cholangiosarcoma ** Aerosol can filler *** Does not include the following who are still alive, so far as known:
Frl5, 22, 23 & 24, G31 & 32, US33 & 36
Page 4 7
(Review date 1 January 1989) TABLE 7
ASL CASE NUMBERS BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION (EXCLUDING It.01)
KEY |
1
1
1
EVENTS |
| WESTERN EUROPE
1 NORTH AMERICA
| REST OF WORLD |
11
1
1
11
1
1
1 1939 1
1 US24*
1
1 40 1
1
1
I 1 |Fr11 ,Fr16
1 21
1 C3.US27 I US13, US29.US40
1 1
1 3 |Fr14,Fr24***
1 C2,US19.C11
1
1 4 IUK1,Fr23*** 1 5 | Sw2
I Cl ,C5,US5,US7,US28,US35 1
I C4,US3,US9,C12
1
1 6 |Fr1,Fr3,Sw4 I 7 | Sw3 1 8 |Fr9, Frl7
I C7,C9,US8,US11,US21,US31 1
| C6,US22,US26
1
1 US1
1
1 9 |Frl2,Fr4
I US12.US41
1
1 50 |Fr7,N1,UK8,UK9 1 1 |Swl,UK5,Fr20,G30
1 US16 1 US10, US32
|Y2, Cz2
1
1 2 | G3**
1 US4
1
1 3 |G15,It3,G26,G31*** 1 CIO, US37
1 4 |G7,G8,UK4,G19
| US18,US33***
1 5 I Gil,G16,G18, Fr15*** I US2,US17,US20,US34
I Japl,Y1 |Y3
1
1 |G23,G28,G32***
1
1
1 6 |FR10.G1,UK15
| US36***
1
1 7 |Fr8,G4,It2,G2,UK12 | C13
| Cz 1
1 8 |Fr6,Bl,Fr22***,It7 1 US23
|Jap2,Y4
1 9 |Fr2,It4,Frl9,Fr21
1
1
1 60 |G5,G13,G25,G28,It6
I US39
1
1 1 |G9,G10,G12,G17,G20,G22 1 C8 1 2 |G6,UK6,G21,B2,G29,Fr25 | US6
1 1
1 3 IFrl3, UK7,Frl8,UK16 1 US38
1
1 4 I Sw5
1 US30
1
1 5 |Fr5,UK11 1 6 |UK3, UK10.UK14
1
I Jap3
1
1 7 | It5
1 ^' 1
1 8 IUK13
1
1
Viola
1
|
9 | G24 70 1
1 1
1 1
1 11
1
1
Maltoni 1
2I 31
|1
| Total 185
1 1 1
1 51
1 1 1
19
11
1
* Cholangiosarcoma (US24) ** Aerosol can filler (G3)
*** Frl5, 22, 23 & 24, G31 & 32, US33 & 36 are still alive, so far as known
WpX/ASL2 - LANGIOCASES.22
GENC 003378
Page 48
WPX/ASL2 - LAN3IOCASES,23
(Review date L January 1989)
TABLE 8 WESTERN EUROPE FVC PRODUCERS - START-UP DATES vs ASL CASES (OMITTING 003 & It.01)
ISTART-UPI COUNTRY NAME | OCMPANY NAME
| YEAR 1
1
| 1931 |West Germany |BASF
| LOCATION
1
ILudwigshafen
| ASL CASE NUMBER | 1|
11
YEAR OF 1st Exposure
I I
1
| 1933 ]West Germany |Wacker
|Burghausen
11
I
| 1938 |Italy
IMontecatini |Acna
| 1939 |France
|Rhone-Poulenc/ | St Fons
1 IChloe/Atochem 1
|04,07,11,15,23,24|57,54,55,53,55,69,60,531
125,31,32
155
(
11
1
103,09,10,11,14 115,16,17,23
146,48,56,41,43, 155,41,48,44
I
1
| 194Q |United Kingdom|ICI/EVC
IRunoom (Closed 1948)
1
1
|United KingdomlICI/EVC
|Hillhouse
101,04,12,16
144,54,57,63
1
| 1945 (Sweden
(Kemamrd/Nobel (Sundsvall(Stockvik)(01,02,03,04,05 151,45,47,46,64
1
| 1946 |France
|Rhone-Poulenc (Roussillon
| 1948 |United Kingdom|BP Chem/ICI/EVC|Barry
101 146 |03,05,06,07,08,09|66,51,62,63,50,50
!
1
II |West Germany |CWH/Hu1s
1
|Marl
110,11,13,14,15 166,65,68,66,56
109,10,26,29
161,61,53,62
1 1
| 1949 |Belgium
|Solvay
IJemeppe
|01,02
158,62
1
| 1950 | France
(PCUK/Atochem IBrignoud
(02,04,05,06,12, 19|59,49,65,58,49,59,
1
11
1
120,24
151,43
1
| France
|Rhone-Poulenc/ | St Auban
107,22
150,58
1
1 |Chloe/Atochem 1
11
1
|Holland
| Shell
lEtemis, Rotterdam 1
1
1
|Norway
| Norsk
IHeroya, Porsgrunn 101
150
1
I 1951 (Switzerland I 1952 | Italy
ILonza/ICI/EVC (Sins | Montedison/ ITemi
1
107
1
158
1 1
1
IMoplefan
1
11
1
|Italy
|Montedison/EVC |Fbrto Marghera
102,06
157,60
1
I 1953 I Austria
IHalvic/Solvay IHallein
1
1
1
|France
|Solvay
ITavaux
108,13,18,25
157,63,63,62
1
I Italy
(Solvay
| Ferrara
103
153
1
|Spain
|Rio Rodano
IHemani
1
1
1
|United Kingdom|BXL/BIP/NORSK lAycliffe
I West Germany (Hoechst
IGendorf
I 118
1
155
1 1
I 1954 |West Germany IDynamit
| Troisdorf
11
1
1 1955 (Spain
| Monsanto Iberia|Monzon
1 1956 |Spain
ICaiqsa
ISabinanigo
101,02,08,12,16, 17156,57,54,61,55,61, |19,20,2iV22,27, 30154,61,62,61,55,51
11
11
1
1
I
1
I |Hispavic/Solvay|Torrelavega
1 1958 I West Germany |Solvay
|Rheinbetg
1 1
1 1
1 1
1 1960 |Italy
|S C Raverma/EVCI Ravenna
|04
159
1
I West Germany ILonza/ICI/EVC IWaldshut
106,13,28
,162 60,60
1
1 1961 (Italy
| Mootedison/EVC |Brindisi
1
1
1
1. 1962 I Portugal
(Cires
| Oporto
1
1
1
1 1965 |France I Italy
|Rhone-POulenc IMontlucon
IPozzi
|Ferrandina
121 1
|59
1
!
1
|Italy
IRensac
|Mira, Venice
105
167
1
(West Germany IWacker
IGologne
i
1
1
1 1966 IWfest Germany | Hoechst
1 1967 (France
(Atochem
(Khapsack(Frankfurt) 105*
IBalan
1
160
1
1 1
|Spain |Greece 1 1968 |Belgium
|Rio Rodano |Esso Pappas IBadiphil
| Miranda de Ebro IDiavata Salonika I Antwerp
1 1 1
I
1
1
1 1 1
1 1969 |United Kingdom |Vinatex/Norsk (Staveley
I
1
I Italy
(Rumanica/EVC 1 Cagliari Sardina 1
1
SENC 00S3??
Page 49
Table 8 - Continued WESTERN EUROPE PVC PRODUCERS - START UP DATES vs ASL CASES (CMHTPC 003 & It.01)
|START-UP| ODUNTEY NAME | OCMPANY NAME |
LOCATION
| YEAR 1 1 1970 I Italy
1
|SIR
1
|Porto Torres Sar
| United Kingdom|ICI/EVC
|Runcorn
I 1971 | Spain
| Hispavic/ Solvay | Hartorell
I Sweden
|Kemanord/Norsk |Stenungsund
| United Kingdom 1 BP Chon
IBaglan Bay
1 1972 | Finland
I Pekerta
| Svartback
| Holland
|DSM
|Beek Limburg
I 1976 IFrance
|Soc Art D'vinyl | Maziqgarbe
1
|(CDF)
|
1 1977 |Spain
| Monsanto Iberia| Tarragona
| 1982 IWfest Germany |ICI/EVC
jvoslapp
1 | | Wilhelmshaven
1 ASL CASE NUMBER | 1!
11 11 11 11
I1
11 11
1I
11 11 11 11
YEAR OF 1st Exposure
* Laboratory worker in Research Department
v^
WPX/ASL2 - LA1GI0CASES,24
GENC 008380
Page 50
TABLE 9
(Review date 1 January 1989)
USA PVC PRODUCERS - START-UP DATES vs ASL CASES
|START-UP I COMPANY NAME
1 LOCATION
| ASL CASE I YEAR OF
|
YEAR 1939?
1
|*UCC
1
| Dow
1
I S Charleston
1
1 Midland (made
I NUMBER
| 1st EXPOSURE
107,13,19,21,24, 144,42,43 ,46,39,
127,28,29,31,35 141,44,42 ,46,44
|1
| | I
1
I 1940? | *BFG
1 Saran copolymer) |
1
1
I Louisville
101,02,03,04,05, 148,55,45 ,52,44, |
1 1 106,09,16,17,22, 162,45,50 ,55,47, |
1
19.46 |*UCC/Dow
! 126,33,34,37,40 147,54,55 ,53,42 |
1 Texas City (Partially closed 1977) 1
1
1947 1948
| Goodyear | Firestone/ | Occidental
1 Niagara Falls 1 Pottstown
1
108,10,11,20,41 |46,51,46 ,55,49 |12 | 49
11
1 1 1
| Uniroyal
1 Painesville
|
1
1
1
1950 | Monsanto
! (closed 1975) 1 Springfield
| |32
1
151
1 1
I 1952 | Dow
1 (Closed 1975
|
1 Midland (No PVC since c 1975)
1 1
1 1
| BFG 1953 | Diamond/BFG
1 Avon Lake 1 Deer Park
|18 |
154
1
1 1
1954 | General Tire/ ** 1 Ashtabula
|36
156
1
| DiversiTech
1 (Closed 1984. Reopened 1986 by Vygen)
1
1956 | Air Products
1 Pensacola (Pace) |
1
1
| Atlantic Refining 1 Brooklyn(Closed late 1960s)
| Borden
1 Leominster (Closed 1984)
I
1
1 1
| Conoco
1 Hebronville (Closed 1975)
1
1
| BFG
1 Niagara
|
1
1
| Great American
1 Fitchburg
J 23
158
1
| Plastics | Hooker
1 (Closed 1983)
|
1 Hicksville (Closed 1980-81)
I
1
1 1
| Pantasote 1957 | Atlantic Tubing
1 Passaic(Closed 1984) 39 1 Cranston (Closed 1967)
160
1
1 1
| Tenneco/
1 Flemington NJ
|30
|59
1
| Occidental
1 (Closed 1985)
|
1
1
1958 | Keysor Century
1 Saugus, Cal
|
1
1
| Air Products
1 Calvert City(Paducah) 38
163
1
1
1 (Closed March 1982 Re-o'pened October 1983)
1
1960 | BFG
1 Long Beach, Cal (No PVC now.
1
1
1
1 Formerly shown as Watson)
1
1
| Borden
I Illiopolis
1962 | Tenneco/Occidental! Burlington NJ
| |
1 1
1 1
1963 | Conoco/Vista
1 Aberdeen, Miss
(
1
1
| Stauffer
1 Long Beach, Cal (Closed 1982)
1
1
1965 | Conoco/Olin
1 Assonet, Mass (Closed by Olin 1975)
1
1 Ethyl
1 Baton Rouge (Closed 1984)
1
1
1966 | Diamond/Georgia 1 Delaware City
|
1
1
| Gulf
1
1
|Gen Tire/Pantasote 1 Mt Pleasant W Va |(Closed 1982)
I
1
1 1
1967
| BFG
1 Henry,111
|
I
| Stauffer/Formosa 1 Delaware City (Sold to Formosa 1981)
1 Allied/Robintech/ 1 Painesville, 0. (No PVC made by Robintech.
1 1 1
I Georgia Pacific
1 GP converted to polystyrene)
1
1
| Hooker/Occidental 1 Burlington NJ
|
1
1968 IFirestone/Occidental Perryville (Closed 1982)
1
GENC
WPX/ASL2 - LANGIOCASES,25
Continued
TABLE 9 (Continued)
USA PVC PRODUCERS - START-UP DATES vs ASL CASES
|START-UP| I YEAR 1 | 1969 1
I I 1971 1 I 1972 1 | 1973 1
1974" 1
I
1
| 1975 1
1
1
1
| 1979 1
1
| 1983 1 I 1986 1
COMPANY NAME
BFG
Goodyear/BFG
Conoco/Vista
Nat Starch
Borden
Atlantic Tubing/
Tallyrand
Shintech
Certain-teed
Georgia Pacific/
Georgia Gulf
Tenneco/Occidental
Firestone/
Occidental
Formosa
Vygen
**
LOCATION Pedricktown NJ
1 ASL CASE 1 NUMBER
1
Plaquemine
1
Oklahoma City Meredosia, 111
1 1
Springfield
1
Cranston RI (Closed 1982)
1
Freeport, Tex
1
Lake Charles Plaquemine, La
1 1
1
Pasadena, Tex
1
Addis (formerly shown as
Plaquemine)
1
Point Comfort, Tex|
Ashtabula, Ohio 1
| YEAR OF I 1st EXPOSURE
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
* My databank has no information on UCC before 1946 or BEG before 1950 ** Refer to same plant at Ashtabula, bought by Vygen from DiversiTech.
NB Some of the plants in this list were closed down, some have changed ownership over the years, some have changed their product.
WPX/ASL2 - LANGIOCASES,26
GENC GQ83S2
(Review date 1 January 1989)
TABLE 10
CANADIAN PVC PRODUCERS - START-UP DATES vs ASL CASES
|START-UP| `| YEAR |
COMPANY NAME
I LOCATION
1
I ASL CASE | NUMBER
| YEAR OF | 1st EXPOSURE
11
| 1943 1 Goodrich
| Shawinigan
|(1941?) 1 (Formerly Gulf)
|
1 (Formerly Shawinigan Chemicals)
1 (Formerly Canadian Resins & Chemicals)
11
101,02,03,04,05 144,43,41,45,44,
106,07,08,09,10, 147,46,61,46,53
|11,12
I 43,45
11
1 1 11
1 1 11
j 1951 1 Monsanto
| La Salle (Closed 1975)
1
1 1 11
1 1 11
| 1957 1 Goodrich
| Welland (Niagara) 1 13
157
1 1 11
1 1 11
| 1966 1 Esso (Imperial Oil) | Sarnia
1
1
1 1 11
1 11
| 1979 1 Diamond Shamrock Alb/| Fort Saskatchewan 1
1 BF Goodrich
|
1
I
1
1
Page 53
(Review date 1 January 1989)
TABLE 11
EASTERN BLOC PVC FACTORIES - START-UP DATES vs ASL CASES
START-UP | COUNTRY NAME I COMPANY NAME
' YEAR 1
1
Pre 1939 I East Germany (State Company
1941 |Russia
| State Comps
1950 |Yugoslavia
IJugo Vinil
1951 | Czechoslovakia |State Comps
1955 |East Germany |State Comps
1956 |Rumania
(State Comps
1957 |Poland
|State Comps
|Rumania
(State Comps
11
1958 |Rumania 1959 |Hungary 1961 |Ruma nia 1963 I Yugoslavia 1965 |Bulgaria 1 1967 |Poland
\ 1969 IRussia 1970 (Rumania
|Russia 1 1972 iYugoslavia
(State Comps (State Comps | State Comps | Ohis |State Comps |State Comps |State Comps |State Comps | State Comps IVinilplastika
1975 |Czechoslovakia,| State Comps
|Russia
| State Comps
1 1976 (Yugoslavia
1 Hip
1 1977 |Rumania
|State Comps
I LOCATION
1
|Schopau I Vladimir et al |Split |Novaky (Bitterfeldt (Icechim (Osweicim (Dwory) |Tirnaveni |Turda |Risnov IBerente Borsod |Borzesti 1 Skopje |Varna |Tarnow I Dj erjinsk (Rimnicu Vilcea |Volgograd |Zadar |Neratovice IKalush Area (Pancevo IRimnicu Vilcea
| ASL CASE I NUMBER
1 1
101,02,03,04
101,02 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
I
( YEAR OF 1 1st Exposure
1 1
(53,50,54,58 157,50
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
GENC 008384
Page 54
TABLE 12
(Review date 1 January 1989)
JAPANESE PVC PRODUCERS - START-UP DATES vs ASL CASES
|START-UP | YEAR 1 1950 1
1
1
1951 1952
1 1
COMPANY NAME
Chisso Corp Kanegafuchi Kag Tekkosha Mitsui Toatsu Mitsubishi Mon
1951
1955 1956
1 Sumitomo Kag 1 Denki Kagaku I Nippon Zeon 1 Toa Gosei 1 Ryo-Nichi 1 Nippon Zeon 1 Nisshin Kagaku
1957 1 Kureha Kasei
1960
1964 1966 1967
1 Shinetsu Kag 1 Denki Kagaku 1 Kanegafuchi Kag 1 Chisso Corp 1 Tokuyama Seksui 1 San Arrow Kagak
1968 1970
1 Sumitomo Kag 1 Ryo-Nichi 1 Shinetsu Kag 1 Chisso Corp 1 Denki Kagaku
1971 1973 1974
I Kanegafuchi Kag 1 Kawasaki Yuki 1 Mitsui Toatsu 1 Nissan Kagaku 1 Shinetsu Kag 1 Tekkosha 1 Asahi Glass 1 Toyo Soda
1
1975 1977
1 Central Kagaku 1 Toyo Soda 1 Unknown
| LOCATION
1
| Minamata | Osaka | Sakata | Nagoya | Yokkaichi | Kikumoto | Shibukawa | Kambara | Tckushima | Uozu | Takoaka | Takeo | Nishiki | Naoetsu | Ohmi | Takasago | Chiba | Tokuyama | Tokuyama | Chiba | Mizushima | Tokuyama | Mizushima | Goi (Chiba) | Kashima | Kawasaki 1 Sakai | Chiba | Kashima | Yokkaichi | Hayatsuki | Sakata | Yokkaishi | Kawasaki | Yokkaichi | Kashima
| ASL CASE | NUMBER
1
| 02
1
1 01, 03
1 1 1 1 1 1 1 1 1
I
1 1 1 1 1 1 1 1 1 1 1
!
1 1
I
1
!
1 1 1 1
1 YEAR OF 1 1st EXPOSURE
1
1 58
1
1 53, 65
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
I
1
!
1 1 1 1 1 1 1 1
G'ENC 008385
Page 55
(Review date 1 January 1989)
TABLE 13
SOUTH AND CENTRAL AMERICAN PVC PRODUCERS
START-UP|
YEAR 1953 1954
1 1 1
1955 1
1956 1
1960 1
1
1961 _ 1965
1 1
1966 1
1967 1
1
1968 1970
1 1
1
1971 1975 1976 1977
I I
1
1
1978 1
I
1
1979 1
COMPANY NAME
Monsanto Mexica Policyd Geon Do Brazil Elchlor/Solvay Electrochlor Viplastic Indupa PET Columbiana Carburo De Col Plasticos Omega SOC Paramonga Primex Policasa Petro Dow Polimeros Mex Rico Chemicals Petroplas Indust Resistoc Huls Brasil Polychem Policyd PET Camacari
| LOCATION
I
1|
| Lecheria (Mexico)
1
| Mexico City (Mexico)
1
| Sao Paulo (Brazil)
1
| Sao Caetano (Brazil)
1
ICapitan Bermudez(Argentina) 1
| Mendoz (Argentina)
1
| Cinco Saltos (Argentina) 1
| Cartagena (Colombia) | Medellin (Colombia)
!
1
| Mexico
1
| Paramonga (Peru)
1
| Puebla (Mexico)
1
| Managua (Nicaragua) | Conception (Chile)
!
1
| St Martin Puebla (Mexico) 1
| Guyanilla (Puerto Rico)
1
| EL Tablazo (Venezuela)
1
I Tlazcala (Mexico)
1
| Cubato (Brazil)
1
| El Salvador
1
| Coatzacoalcos (Mexico)
1
| Camacari Bahia (Brazil)
!
ASL CASE NUMBER
1 YEAR OF
[
1 1st EXPOSURE |
1
1
1
1
1
1
1
!
1
1
1
I
1
1
1
1
1
1
1
1
1
1
WPX/ASL2 - LANGIOCASES,30
GENC 008386
Page 56
(Review date 1 January 1989)
TABLE 14 AUSTRALASIAN PVC PRODUCERS
START-UP DATES
START-UP |COMPANY NAME
YEAR
I
I
Mid 1950s |
I
1960s |
I
(Late 1970s|
ICI Australia B F Goodrich ICI Australia
LOCATION
Botany, Sydney Melbourne Laverton Melbourne
ASL CASE NUMBER
YEAR OF 1st EXPOSURE
WPX/ASL2 - LANGIOCASES,31
GENC 008387
Page 57
(Review date 1 January 1989)
TABLE 15 MIDDLE EASTERN PVC PRODUCERS
START-UP DATES
START-UP 1 COUNTRY NAME
DATE
1
1
Sept 1986 1 Saudi Arabia
1
1
I
1
1
1
1 COMPANY NAME 1
11
LOCATION
11
| National Plastic |Arabian Petrochemical Company
| Company
|Madiant
I (Ibn Hayan)
IAl-Jubail
1 |Al-Sinahyah
11
11
11
WPX/ASL2 LANGIOCASES,32
GENC 008388
Mini
ICl CHEMICALS & POLYMERS LIVER Ari|j; J ounrcoBJi Luauti
1 12
J
COUNTRY AND |NAME OR
REFERENCE NO
|INITIALS
J
3i i i
GATE OF i
BIRTH 1
i
4 COMPANY
_L
i5 i i
i
6 FIRST VC
7 DATE OF
18
1 1 |ACE AT
t9
|YEARS OF |EXPOSURE
10 |
1
i
YEARS OF]
11 DATE OF
12 i n i i li
ii
H1ST0L0GICALIESTIHATEDI
u
1 13 1 1 (OTHER
\ 1 1 |
i FACTORY EXPOSURE DIAGNOSIS!DIACNOSISITO
EXPOSURE! DEATH
i
i
(DIAGNOSIS!
i
CONFIRMATION!EXPOSURE (OCCUPATION |CAREER
|
(LEVEL
|
|HIGHLIGHTS!
i
_L _L_________i
JL
L
1!
11
*
It OTHER COHMENTS
1 I I l i
l i
ill
ill
il
i
ill
III
Ilf
III
III
III
II
I
III
III
111
111
i
i ili ll i i i. i i j lI l t I III II I I II I i II I I II I I
I III II I I II I I II I I
ii i i
i ii l
i ii I
i ii i
i li l
III
I
I IJ I
I II I
I II I
I II I
I III
I II I
I II I
l II I
i ii i
ii ti ij it If || #I II II
I| || If II
ai
T19
GENC
v
J3S9
