Document bBK9dDwa4krNk8oE19V2Kk4y3

February 13, 1963 TOXICITY AND SAFE HAHPLINO OF FYERAUL A-200 Animal toxicity atudlaa with thla produot have indicated that tha oral lethal doae (LDc0) to rata la 10,300 milligrams per kilogram. The lethal dote when the material waa applied un diluted to the unbroken akin of rabblta la approximately 1230 mllllsrama per kilogram. ' We oonolude from the above that aooldental Ingestion on the part of humana la not a particular hazard in view of the high oral lethal doae In rata. Similarly, alngle massive akin exposure* should not be Immediately hazardous. The lethal doat obtalnad In skin penetration atudlee la aueh, however, that prolonged and repeated akin contact should be avoided beoauae of possible systemic effects, in addition, prolonged and repeated akin contact may lead to akin irritation. We also feel that vapor Inhalation should be avoided when the fluid la heated to elevated temperatures, suoh exposure again relates to prolonged or repeated exposures rather than short term massive or acute exposures. In the case of the latter, worlasen would not voluntarily expose themselves to concentra tions that are hazardous beoauae of Irritation of the respira tory tract. Tha use of Pydraul A-200 In industrial hydraulio fluid appli cations should not present toxicity hazards during the transfer of the fluid frcn original containers to the hydraulic system. Obviously when the fluid le within the hydraulio ayatam, there should be no exposure and consequently, no hazard, in the event of rupture of hydraulio lines and subsequent splashing or spraying of the fluid on the heated surfaces, vapors of the fluid and possible decomposition produots (depending on the temperature of the heated surface) may be Irritating If Inhaled to the degree that workmen will not voluntarily expose them selves to toxic concentrations. No hazardous exposure should result during the Interval required to shut down the system and obtain suitable respiratory proteotlve devices during repairs to the system. The material in this report is to be used in development ol the product and may be given to reaponsihle sales contacts, but it is not to be used by Ihem in advertising copy. The source of this material ib not to be divulged until it appears in formal publications. No exceptions to tha established rule ^^5 may be. made without the approval of the Medical Depart, ment in St Louis.Customers' inquiries regarding matters of toxicitv are to be referred ns before to tire Medical Depart' ment in St Louis lor reply. ' -- Monsanto Chem- 1.1 ' ni'ov ' 071307