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19th Oct. 1981 Judith A.Zack M.P.H., Monsanto Co 800 N.Lindbergh Blvd St Louis MO 63166 Thank you very much for the reprint of y e u r paper" The morta lity experience of workers exposed to tetrechlorodibenzedioxin in a trichlerephenol process accident". The mechnism of the accident seems to be very similar to that from Seveso. I would be interested, how much the building was contaminated er the environment of the plant. Possibly because the accident was in 1949, it was not ascertained. May I ask you to do me a great favour and tel me, what was the fate of the building, how it was decontaminated/ if it was decontaminated / and if you could post to me copies of the literature that are in referencies under number 3.,4.,5,6.,?. I could send you all papers about cur accident. any thanks for your kindness and kind regards Sincerely your? : ' : :: a L . SUBJECT TO PROTECTIVE ORDER. f is*7&nfet than that of any previous study, and the follow up is complete. Therefore, although the cohort is small, it represents the best opportunity so far to study the long term effects of TCDD on mortality. By augmenting these data with the results of comparable mortality studies, the long-term effects of TCDD may be more definitely evaluated. The authors wish to thank Mrs Janet Yung. Mr Randy Picolet. and Mrs Phyllis Korte for their assistance with the data collection References 1 International Agency for Research on Cancer IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man Vol 15 Some Fumigants, the Herbicides 2,4-D and 2.4.5-T. Chlorinated Dibenzodioxins and Miscellaneous Industrial Chemicals Lyon IARC. 1977. 2 Kimmig J and Schulz KH Occupational acne (so-called chloracne) due to the chlorinated aromatic cyclic esters Derm ilologica 115:540-546, 1957 V3, Ashe WF and Suskind RR Reports on chloracne cases. Monsanto Chem ical Company. Nitro. West Virginia Reports of the Kettering Laboratory. December 1949 and April 1950 (4. Suskind RR: A clinical and environmental survey. Monsanto Chemical Company, Nitro. West Virginia. Report of the Kettering Laboratory. July 1953 (_5. Suskind RR Chloracne and associated problems Report to the Conference of the National Institute of Environmental Health Sciences on Chlorinated Dibenzodioxins and Dibenzofurans, April 3, 1973 [ b j Suskind RR Chloracne and associated health problems in the manufacture of 2.4,5-T Report to the Joint Conference. National In stitute of Environmental Health Sciences. International Agency for Research on Cancer. Lyon, France, January 11. 1978 7 Young AL, Calcagni JA. Thalken CE. et al The toxicology, en vironmental fate, and human risk associated with herbicide orange and its associated dioxin U S Air Force Occupational and En vironmental Health Laboratory Report OEHL TR-78-92. Brooks Air Force Base. Texas, 1978 8 International Agency for Research on Cancer Long-term hazards of polychlorinated dibenzodioxins and polychlorinated diben zofurans IARC Internal Technical Report No 78/001. Lyon. 1978 9 Jirasek L. Kalensky J, and Kubec K Acne chlorma and porphyria cutanea tarda during the manufacture of herbicides Cesk Dermatol 48 306-317. 1973 10 Jirasek L. Kalensky J. Kubec K. et al Acne chlorina. porphyria cutanea tarda, and other manifestations of general poisoning during the manufacture of herbicides II Cesk Dermatol 49-145-157. 1974 11 Pazderova J. Lukas E. Nemcova M. et al Chronic poisoning by chlorinated hydrocarbons formed in the production of sodium 2.4,5-tnchlorophenoxyacetate Prac Lek 26 332-339, 1974 12 Kociba RJ. Keyes DC. Beyer JE, et al Results of a two-year chronic toxicity and oncogenicity study of 2,3,7.8-tetrachlorodibenzop-dioxin in rats. Toxicol Appl Pharmacol 46 279-303, 1978 13 Van Miller JP, Lalich |J. and Allen JR Increased incidence of neoplasms in rats exposed to low levels of 2.3.7.8-tetrachlorodibenzop-dioxin. Chemosphere 6 537-544, 1977 14 Monson RR Analysis of relative survival and proportional mor tality Comput Biomed Res 7 325-332. 1974 15 Eigth Revision. International Classification of Diseases. Adapted for Use in the United States U S Department of Health. Education and Welfare. Public Health Service. PHS Publication No 1693. Washington U S Government Printing Office. 1977 Future Risk In the industrial countries we have grown rich during the age of hierarchical business corporations, in which each executive arranges what the man below him will do with his hands, all the way down to the man turning a screw on the assembly line Now, two rather fundamental things have happened. First, we have begun to realize that workers in rich countries don't like working in such places. Secondly, the rich countries are moving out of the postmanufacturing age, but they still have great hierarchical cor porations in which executives sit behind their desks trying to arrange what the man below will do with his imagination This no longer works. New forms of business organization will have to be found, probably changing big corporations into confedera tions of entrepreneurs The firms and countries that will go bust in these circumstances are those that try to replace hierarchical corporations by even more ossified forms of hierarchy -- say, by deciding that you mustn't have a boss trying to arrange what free men do with their imaginations, but can have a trade union committee doing so in stead -- From "United States Can Keep Crowing -- And Lead -- If It Wishes" by Norman Macrae. in Smithsonian. Inly 197b 14 Mortality Experience of Workers Exposed to Tetrachlorodibenzodioxin/Zack and Suskind