Document bBDyMg6L0bBXE3b1pvLRXBay6

YY) m SODFEEFPHAAERRATTLMMTEEHNNTT OF HEALTH Health Risk Assessment UnHHie,eaalElitnhhvBiBaoasnsemeeddnGGtauulidHaienacdletfahfoorDrniWW vaictsaieteoernr Health Risk Assessment Unit, Environmental H6e5a1l.th20D1i.v4is8io9n0 651-201-4899 W Weebb PPuubblliiccaattiioonn DDaattee:: MMaayy 22001177 TCTAooSx:xiicc1oo7l6l3oo-g2g3i-icc1aaalclidSS)uummmmaarryy ffoorr:: PPeerrfflluuoorrooooccttaannee SSuullffoonnaattee CAS: 272109972060283851-12---3155-4661---989(a(((cadaimidme)mmtohoannniiouulmmamssiaanllett))salt) 7222709792945255.5-733--9197-4-233-85((pp((doloiitteatathsshissuaiimunumosmallastsm)aallittn))e salt) `Synonym[N2Nso9:to4et5e:P7:F-pp7Oee2Srr-,fu5ludP(orleriortoohfociicututmoaarnnocosoaaactlttteea)naaensniuioolnnfoddnooieecssacnnioodtt hhaavvee aa ssppeecciiffiicc CCAASS nnuum mbbeerr,]] Synonyms: PFOS, Perfluorooctane sulfonic acid MaMnDDdHHkcceooynnsddtuuuccdtyteeidddeaantffoiofcciuucssateeiddonrreoc--oeonvvtaalaluuiaantteiidoonnw,,itwwhhihiniccthhherreeEltiPieeAdd hhHeeeaaavlvitilhlyyEuufppfeoocnntsEEPSPAuA'p'pssohhraatzzDaarorddcauasmssseeensstssmfmoerenntt aPPtheneerdrfftlkluouexooyirrcosoootolucocdgttaiyancniaeedleSSlnuiutltlieffforiocannataautttrioeeenw((PaPcFFsoOOnnSSto)a)tinrrceeeolldeneadwasusicetehtddeiniidnn.thMMeaayyEP22A0011H66e((aEElPtPhAA 2016a). Effects 2016a). A complete evaluation Support Document for A complete evaluation ooff the toxicological literature was not conducted. SShhoorrtt-tteermm,, SSuubbcchhrroonniicc aanndd CChhrroonniicc* -~ NNoonn-CCaanncceerr HHeeaalltthh BBaasseedd VVaalluuee ((n1HHBBVV)) == 00..002277 ppggl/LL*** a*"DrDeuueethtteoo mtthohesethhiaiggphhpllryyopbbriioioaaatcecccudumomsuuellaamtietvteerinncaatatuunrreetoohffePPsFFtOaOnSSdaaarnndddehhquuuammlaainnonhhoaallfd-lelifreeivooefftnnheeeaaHrrlyBlyV5.4w5.6ayyseeaanrrsos,l, sasepeprrruuommpriccaootnenc.ceenSnthtroraartttii-oonnss tb{aeeerreremmntheeerxxeppmcoooosssmuutrmreeaesspnpdhhreaaovdvpeerfiaotthrtheeesdhppooooserteentinemitianael,ltrt{ois0cussabitnacadhyyotiirhnniettchhs.eetaabbnnooddddayycrdhffrooeorrnqaaiunncadteeiuoxxrnttaeetntnioddoendesdde.rppivTeeehrriietoohd2de0oo1Hffm7BtiemVH.eBw.VaTTswhheaenrsoreetfdfaooeprrreepiavrasoeipdsnriniugasgtlieleen.gHHSahBBoVVrt-hhaass ttbpooerxxeeiiscnceoonkrkeitinnceeedottmiibcceml((oeTTwnKK.)d) emmdoodfdoeerllsddheeovvreet-lltoeopprmeedd, by MDH with input fom subchronic, and chronic by MDH with input from an extemal peer review panel. durations. The 2017 HBV was an external peer review panel. Model details derived using Model details aaarree presented below. "*n*RaRteileoalnatatilivveGeeSSnoeoruuarrlcceepoCCpoounnlrtairiibbouunttsiioo0nn ((rRReSSpCCr)e:):sebbnaassneeoddn-oownnatcceuurrrrreeexnnpttobbsiiuoormmeoson,nitiatoonrriiRnnggSCsseeorruufmm 0.cc5 oo(nn5cc0ee%nn)ttrrwaaattisoinossnelfferrocomtmedlloofccraallwaaanntdder ingestion. national general ingestion. populations to represent non-water exposures, an RSC of 0.5 (50%) was selected for water oIInrnttauakpkepeeRRraatpteee:r:cIIennnkkteeieeeppbiirnneggaswwtiimtthihlMMk ODinHHta'sskepprrraaalcceitisicce(,,Ta99b55lthe pp1ee5r-rcc1,eennUttiiSleeEwwPaAattee2r0r1ii1nn)tfaakkweeerrraaetteeussse((dTT.aabbBllreeea33s--1i1maialnnkdd c33o.-n33,c, eUUnSStaEEtPPiAAon22s00w11e11r)e). cbocararleluccauplslpataetftereedddpebbirnyycfeammnnatutlillteteipxplpblyyoriisennuaggrsettthmheseiclkemmnaiaantrttieeaorrk,neaalalrasspteeeerrrsuiumo(mTdoaccfbooelnnexccce1eln5ntu-trs1raai,tvtiiUeooSnnbErbbePyyaAsaat2fPP0eFF1eOd1Oi)SSnwgbberfrreoeeraaossuintsmmeeiyidlkke. tatBrrraarnewnsaasfsefsetrmrfuaiflsacktecocdtoroarnosocfefrne11pt.3r3ra%%e.tsi.oeFnnFotsorartwihtehvereee ofa reasonable maximum breast-fed infant exposure of a reasonable maximum exposure scenario, exposure scenaric a period of scenario. exclusive breastfeeding for one year was used as representative ASAisgsiniimmfpipclaeneteqqduiaugitati.tioonHnowiissetvtyyeppriic,caalilhllyy usfsoxecidcootokincceaalllicccuullmaaotteedeHHlBBuVVsSsedaattothhdeeerppiaavrrtet pptherer bbHiiBlllioVlnnfollerevvPeelFl wOwiiSthhsrrheeossuwulelttsds rtoohuuantnddsaeeddruttomo one one sc2coio0gnn1nc7ciefeniHcntaBtrrnaaVtttiidcooiongnnssitt.awwiHeenorrsewoteiiwmvmoeppdraai,cgctitthteese.ddtobbxyyicccohhkaainnnggeeetissc in water concentrations a the par model used to derive the HBV for in water concentrations at the part pr ilo level. Asa esul, PFOS showed that serum per trillion level. As a result, tthhee 2017 HBV contains two digits. RReeffeerreennccee DDoossee//CConocnecnetnrtartaitioonn:: (HHECEDHD/CT/DTo(ottSaalDl )UUIFFG=S= 00V..A00F0000R55a1t1s//)11.0000[T==h0e0..0c0o00r00r0e00s55p11onmmdgig/n/kgkggs--eddrum c`c(CcooonnrncIc:ceCeennDntttr(rraSaattDtiiio)ooInnnGifsSss i66Vn..Aa22pF66p/r/1Ro10ap00trsi==)a.t00[eT..00ht66oe33ucsmmogegrf/r/oLeLr.s. piNNonoodneitde:vii:ndttguhhaiisslsessrueemrruumm Source of toxicity value: acaDoesssntseecesressmnmistrnameetnediotn.nb*ty*i]*sM] inDaHppinro2p0ri1a7te to use for individual Source of toxicity value: Determined by MDH in 2017 PFPFOOSS-PPaaggee 11ooff1111 Exhibit aire 33775522..00000011 SSTTAATTEE 0077553344002277 PPooiinntt ooff DDeeppaarrttuurree ((PPOODD):): SfrvoemraLguesbsreerrumetcaon3ce0n0t5r5a)tion fo 72 generation, NOAEL DDoossee AAddjjuussttmmeenntt FFaaccttoorr ((DDAAFF):): Homan Equivalent Dose (MOH, 2017): P(SOpnDeclxiDfCAlF,ea=rd3aany5cee)mR=at0e.g2x=3VLoi0.ug0m0x0e0081o.f6LDi9igs3ir1di0sauy71ti=doan0y.(s0)k0a0=5)1x Human Equivalent Dose (MDH, 2017): maga TToottaall uunncceerrttaaiinnttyy ffaaccttoorr ((UUFF):): UUnncceertrtaaiinnttyy ffaaccttoorr aallllooccaattiioonn:: Crtca ofc): wDI{aneanrcdaaranseoipansesadcel)edstpvuupaeabsboidrtyeygwaearindgdihntg fIomrmduantcaobxaiscehuyncaerretainty Critical effect(s): CCoo-c-cririttiiccaall eeffffeecctt((ss)):: Adcitity endpoints): mGwTIiDneenoohicvvatgreerioholltnoootasppaecmamndeniedniniNim,cyKaaellndc,:loedllHclieravdapeereaacrctsiwryeceed,ia(gsgihdlevteudeccrcnor)haseabseaniysutgseaotedtleseimsro,aapncnl,Icceemdoe.menmcupiarnannecnedariessetaeydhsdsyetbmdleyuemvs,els Additivity endpoint(s): 66..2266 mmgg//LL sseerruumm ccoonncceennttrraattiioonn ((EEPPAA 22001166aa pprreeddiicctteedd average serum concentration for F2 generation. NOAEL from Luebker et al 2005b) 00..000000008811;; TTooxxiiccookkiinneettiicc AAddjjuussttmmeenntt bbaasseedd oonn CChheemmicicaall-- Specific Clearance Rate = Volume of Distribution (L/kg) x 0.000081 Likg-day (US EPA 20162) (Ln2/Half-life, days) = 0.23 L/kg x (0.693/1971 days) = 0.000081 L/kg-day (US EPA 2016a) POD x DAF = 6.26 mg/L x 0.000081 L/kg/day = 0.00051 mg/kg-day 110000 33foforr iinntteerrssppeecciieess ddiifffefererenncceess ((ffoorr ttooxxiiccooddyynnaammicics)s,), 1100 ffoorr intraspecies variability and 3 for database uncertainty (additional studies regarding immunotoxicity are warranted) Decreased pup body weight IInn ooffffsspprriinngg eexxppoosseedd dduurriinngg ddeevveellooppmmenetn:t: ddeellaayyeedd eeyyee `ooppeenniinngg,, iinnccrreeaasseedd sstteerrnnaall ddeeffeeccttss,, cchhaannggeess iinn lluunngg development, decreased glucose tolerance, increased oomffottthhoyyrrroaoxxciitninveeity((TT4a4)n,),daadnneddcrddeeeaccsrreeedaassheeaddbisstuuurarvvitiivovaanl.l,. decreased levels In adult animals: liver weight changes accompanied by cchhaannggeess iinn cchhoolleesstteerrooll lleevveellss aanndd hhiissttoollooggyy;; ddeeccrreeaasseedd lleevveellss ooff tthhyyrrooxxiinnee ((TT44));; ddeeccrreeaasseedd SSRRBBCC rreessppoonnssee,, increased NK cell activity, decreased spleen and thymus weight and cellularity Developmental, Hepatic (Liver) system, Immune system, Thyroid (E) = Sau concetaon's afhor frding pul sth ol and tet sted iposues. Th aes *** Serum concentration is useful for informing public health policy and interpreting population-based exposures. This value is JO Lop me fore aoeA based on population-based parameters and should not be used for clinical assessment or for interpreting serum levels in Tene individuals. 1) Caer rte Lo) Toxicokinetc Model Description STTSheoeirxrsuiucmamockccitnooinencotciecennntMwtrraoaatdstiieooulnnsDsseedccsaabcnnryipbbEteeiPoAccn,aa:llctcuoullcaaatetrdeulffarotomamhtthehee HddEooDsseSe arannoddmcctlleheaearraPanOnccDee rsaaettreuuumssicinnoggncthehneetrffoaoltlloioowwniisnngg equation. equation. This equation was used by EPA, to calculate the HEDs from the POD serum concentrations. ~ Dose m(1g Serum Concentration ("2) = ligt) Wher Where: Dose (nda) =Wate or Beast tae (Uda) Leven Wao tBreosr (ng) Dose (mg/kg-day) = Water or Breastmilk Intake (L/kg-day) x Level in Water or Breastmilk (mg/L) wnand CClleeaarraannccee ((LL//kkgg--dd)) == VVoolluummeeooffddisisttrriibbuuttiioonn ((LL/Akgg)) xX ((LLnn 22//hhaailff--liiffee ((ddaayyss))) TE -- Two exposure scenarios were examined: 1) an infant fed with formula reconstituted with contaminated wwaatteerr ssttaarrttiinngg aatt bbiirrtthh aanndd ccoonnttiinnuuiinngg i ingn estg ione ooffsccoontnttaaimmiino naattneedd wwaatteerr tthhrroouugghh lliiffee;; aanndd 22)) aann iinnffaanntt Pros Pago 201 11 PFOS- Page 2 of 11 33775522..00000022 SSTTAATTEE_0077553344002288 eexxcclluussiivveellyy bbrreeaasstt--ffeedd ffoorr 1122 mmoonnththss,, ffoolllolwoweedd bbyy ddrriinnkkiinngg ccoonnttaammiinnaatteedd wwaatteerr.. IInn bbootthh sscceennaarriiooss tthhee imuiated indiduats began fe vith pre-xisting body burden through placental ansfer of PFOS simulated individuals began life with a pre-existing body burden through placental transfer of PFOS (maternal serum concentration x 46%) based on average cord to maternal serum concentration alos (maternal serum concentration x 46%) based on average cord to maternal serum concentration ratios reported in he terature. The serum concentration of he mother at deivery was assumed 1 56 a reported in the literature. The serum concentration of the mother at delivery was assumed to be at `sstteeaaddyy--ssttaattee.. CCoonnssiisstteenntt wwiitthh MMDDHH mmeetthhooddoollooggyy,, 9955tTMh ppeerrcceenntitillee wwaatteerr iinnttaakkee aanndd uuppppeerr ppeerrcceennttiillee bbrreeaassttmmililkk iinnttaakkee rates were salto Simuiatae reasonable mau exposed didi) A PFOS breasimik ransfer rates were used to simulate a reasonable maximum exposed individual. A PFOS breastmilk transfer factor of 1.3%, based on average brastmik (0 maternal serum concentration ras reported in the factor of 1.3%, based on average breastmilk to maternal serum concentration ratios reported in the erature, was used to caloulats raastmik concentration: According to he 2016 Sreasteeding Report literature, was used to calculate breastmilk concentration. According to the 2016 Breastfeeding Report CCaarrdd ((CCDDCC,, 22001166)),, nneeaarrllyy6656 ppeerrcceennttooff mmootthheerrss iinn MMiinnnneessoottaa rreeppoorrtt bbrreeaassttffeeeeddiinngg aatt ssiixx mmoonntthhss,, wwiitthh 31.4 percent exclusively breastfeeding. The percent breasieeding Cropped (041% ai twelve mons 31.4 percent exclusively breastfeeding. The percent breastfeeding dropped to 41% at twelve months. MOH selecied an exclisive breasieeding curation of one year for 1h breasted nant scenario MDH selected an exclusive breastfeeding duration of one year for the breast-fed infant scenario. Dalypostelimination serum concentration was calculated as: Daily post-elimination serum concentration was calculated as: Serum Cone.o(m5,2) = prev. day serum cone, (m3;2) 4 Tooddaey'sstIentkakoem(omyl] va (i) x wks) TTfooanmmtaai5innttawaieinnllmm2aa5ssssexbbcaarlelaatnnicocene,,reddpaarlileyysmemnaattteeedrrnabalyl issneeerruuCmmeaccrooannnccceeenntrtrraaattetii,oonwnsesraaennddcaflocosusssa--tooeff-d-cchheemmiiccaall iavia transfer transfer to to the the infant as well as excretion represented by the clearance rate, were calculated. fae amma `Summary of Model Parameters Summary of Model Parameters Model Parameter Model Parameter Half-life Volume of distribution (Ve) Volume of distribution (Vd) Vd Age Adusiment Factor Vd Age Adjustment Factor Value Used Value Used 1971 days (US EPA 2016c) | 0.23 Ukg (US EPA 20160) 0.23 L/kg (US EPA 2016c) | 2a2f..1t1eraaggaeege11--133000 yddeaaayyrsss dd(eerccirrseeHaasasiinnnsggettnoo1.211.9207aa)ggee 5-10years 5-10 years and and 1.0 1.0 after age 10 years (Friis-Hansen 1961) CClleeaarraannccee RRaattee ((CCRR)) 00..000000008811 LLk/kgg-d-d,, ccaallccuullaatteedd ffrroomm VVdd xx ((LLnn 22//hhaalflf--lliiffee)) PPllaacceennttaall ttrraannssffeerr ffaaccttoorr ((%%ooff mmaatteerrnnaall sseerruumm lleevveell)) [---- Breastmilk transfer factor (5sof maternal serum ev) (% ofmaternal serum level) Water take Rate (Lkg-d) Water Intake Rate (L/kg-d) 4466%% ((MMDDHH 22001177bb)) 1.39% (MDH 20175) 1.3% (MDH 2017b) | 95 percentile consumers oly (defuit values, MDH 2008) 95~ percentile consumers only (default values, MDH 2008) ((TTaabbllee 33--11 && 33--33,, UUSSEEPPAA 22001111)) BBrreeaassttmmililkk IInnttaakkee RRaattee ((LL--kkgg--dd)) | UUppppeerr ppeerrcceenntitillee eexxcclluussiivveellyy bbrreeaasstt--ffeedd iinnffaannttss ((TTaabbllee 1155--11,, UUSS EEPPAA 22001111)) PrOS-P3a0g11e1 PFOS- Page 3 of 11 33775522..00000033 STSATTAETE_0077553344002299 MMooddeell PPaarraammeetteerr VVaalluuee UUsseedd BBooddyy wweeiigghhtt ((kkgo)) CCaallccuullaatteedd ffrroomm wwaatteerr iinnttaakkee aanndd bbrreeaassttmmiillkk iinnttaakkee rraattee ttaabblleess AA`gruereildalaattniivcveee vssaooluuurrecceetoccaoocnntctroriiubbnuutttiiofononr ffnaaoccntto-orwra((tRReSSrCCe))xpsisosiinuncrceoosrrp.poorMraaDtteeHdd uiinntttioozttehhseetddheeerriiEvvxaapttiiooosnnuroofef aaDehhceeiaasllitthohn-vbbTaarsseeeeddpwwraaotcteeerrss gpprerurfeeildsseaecetnnntctreeeelddavtiianinlvueUUepSSotorEEtPPaicoAAnc2so20u0o0nf00t0wtfaototoreddrneeoarrniniv-vdweeanaatopepnprp-rrewooapxptrprieoiaarsttuereroeRRustSS.eCCssMos.fD. eHMMxDpDuoHHtsiliuzrrreeeellsii.eetddhTeuuhppeEooxvnnpaotlthshueeuesrppoeeefrDrccteeehcnneitstadiaouggnreeaTtmmireoeetnethhsooppddreocicttofoeiscs ddrmeeeaffgflaaenuuciltltttruRRedlSSeaCtCiovssfec((o0p0n.o55t,rr,tiio00b.n.u22ts,,iooaanfnnwddofa00.t2t.eh2reffsaooenrrdcssthhnhooeorrrtnt.--ettwexerarpmmtoe,,srussrruuoebbusccthehtrsrhooanotnificoce,c,xcaapunnorddsduccurhrherir.oonnTgnihicct,eh, evrreearsseluppleeeecvsctatinoivvtfeeltelhyyxe))paoadrsrueeurarbbetaaiossuneerddastpooiennocnittfhhicee em((MlMiaDmDgiHHnniat22ut00id0o0e8n8)o.)h.aflcHHto-ooIwnwfetere,vibveseururt,,icohiinnntotthhhafetethacceaaspsseeeerosoootffhnePP'srFFeOOsxSeSp,r,ouaasmpupprpcleoliisncccaatethtiniaootntnroaootcfficoaaunnnr adRRtuSSariCCnnygnngetehieeveddessrnettaloeogvaaeaccniccstooenuuonxnttptooffnosolruryrttehtheehdrlulooernansggutilotnof his or her current or elimination half-life, his or her current or recent exposures within the such that a person's serum recent exposures within the duration of concern, concentration at any duration of concern, but also from exposure from years given age is not only the result of but also from exposure from years ppaasst.t. SSReIerDruuimmn tcchooenncDceeencntitrsraaittoiinoonnTssreaaerreeprtthohceeesbbsee.ssttBmmieoeamaossnuuirtreeorooiffngccuurmmeuulsaluatstiivvfeeroeemxxppnooesswuurrreeesaainndddencctaasnnwhbbeeo uuwsseeerdde iinnnotppllahaiccseetooorfifcttahhleley (eeRNxxfeDpploosiossnnee.tddhe2tto0oD1cc6eoo)cnn.itstaTaiommhnieinnTsaarteteeereddupmwwraoactcoteeenrcrsesiinnn. tttBrhhaieeotmiEEoaoansnssttitioMMnreiettnthrgrooerscecaasrunnelstbbsieedferuunostsmseeddwnee1tor0werrereseppisrrmieedisseaeernnnttistnnnwmooahnng-o-wnwwaiatteteuerredr eeenxxtopoptoothsshuisuortsreoesers.icfoarlltyhe. Cgg(Neheneenemlesriroaacnlla,lpp2usub0bl(1liiC6cc)D.rrCeeTpph2oo0err1tt7ese)ded.ruiinMnmDtthhcHeeonmmsoceoeslsenttctrtrraeeetcdcioeeannnntst NNRinaaStttiChiooennosafaell5RRr0eee%sppiodofreortrtnotoesnnxwpHHoeusuruemmraasennimfrEEiloxaxmpproowinssauutmrereeargttiononigtEEuensndvtveiiirrotonoonnbtmmhaeoesnsnetetdaalfloonr the + Ahi Chemicals g(hC-DenCd,20c1o7n)s. eMrvDaHtivseeleesctteimdataen RSC of 50% for exposure of background, non-water from water exposures ingestion based on: representedby the 95 + ATppeherhreccigeeUhnnS-tteiEilneePdssA, eecrDroueunmcmsiesccrioovonnanccteiTevnrnetetrreeaatstRiitoiomSnnCafftooecrreionnlfeeinbwwgaocEEfkaa8sgstr0toMM%uenettdtror,ooennrroesenssu-iirdwdeeeannattetssmr ae((0r0xg..p0i0o22n1so1ufmmregsgs/a/fLLreelsspyeerrretuuosmmea)n)c,,tceaaodnunnddbty the for 95th possible unknown sourcesofexposure The USEPA Decision Tree RSC ceiling possible unknown sources of exposure of 80% to ensure a margin of safety to account for wAAissthmmceeonnntttiioaonmneiedndaaatbbeoodvvweea,,tttewwroosteeaxxrpptoionssguurarete bssiccretehnnaaarnriidoosscowwneetrrieenueeixxnaagmmiinningeeedsd:t:io11)n) aaofnnciionnnffaatnnattmffieenddatffoeordrmmwuualltaaerrreetcchoornnsostutigitthuuttIefeedd: awaienni.tddh 2) an infant exclusively breast-fed for 12 contaminated water starting at birth and 2) an infant exclusively breast-fed for 12 months, followed by continuing ingestion months, followed by drinking contaminated of contaminated water drinking contaminated water through through life; water through life. cFFooonrrcttehhneetrffaiirtrssittossncceaentnatarrriiiboou,,tathbhelee fftooorrmdmruuillnaak--iffneegddwiianntffaaennrtt,,btethhleeowwwaaatnteerRr cScooCnnccoeefnnt5trr0aa%ttiiootnnhrttohhuaagtthmmoauaitinntitfaaeiinniss 0aa.ss0e6er0ruumpmL. ciBBoneecnccrcaaeeuuansssteeeraiootnfifotttnhhheeeawtlltoaronitnbeggurthhacaboalnlfe-fclieft,eon,tdrttarhhitneeikossinneegrr(u0uwm.ma08ccte1oornngcbceLeenlnt)otrwraartataiiionosnneRsccSuutCrhrveveoesfieis5sr0vvu%eemrryycthoffrnllaoacttueanagtnnhrddoauteetivvoleeinfnneaaaibsoss0vmm.e0aa6ltll0hiienInJc5cgr0r/eLem.pmeeernncttent threshold for nearly 9 years. increase in the water concentration threshold for nearly 9 years. (0.061 IJg/L) raises the serum concentration above the 50 percent PFPFOOSS--PPaaggee 44ooff 1111 33775522..00000044 STSTAATTEE 0077553344003300 508 serum Concentration, Formula edScar, 95pecan Inkl ae, water on 0080 4g. PFOS Serum Ccncentration, Formula Fed Scenario, 95th percentile intake rate, water conc. 0.060 I~giL 0,035 om R$~ 50% ~ o.o~5 3 0,005 retry 0,000 0 10 2.0 30 40 50 Age (years) AAppppllyyiinngg tthhiiss wwaatteerr ccoonncceennttrraattiioonn ooff 00..006600 pjgi/.L iinn tthhee ccoonntteexxtt ooff a bbrreeaasstt--ffeedd iinnffaanntt rreessuulltteedd iinn nnoott oonnllyy taahnnaeenxxoccneeeeeddyeaaannrcc.eeIonoffottrhheede55t0r0o%%maRRiSSntCCaittnhhrraeessshheoorllddu,,mbbcuuottncoofefnttthhreeateeinnottinirreaetrroeerffeebrreeenlncocewe sasenerruRumSmCccooonnfcce5en0nt%trraafttoiioronnbrffoeoarrsmmtoforereed: infants, the water than one year. In infants, the water concentration shold not exceed 0.027 poll. order to maintain a serum concentration at or concentration should not exceed 0.027 pg/L. below an RSC of 50% for breast-fed ested Serta (Upper Kole) POS Serum Concentrations at Water Cocentt0.o02n Brea_~t fed Scenario (Upper %tile IR) #FOS Serum Cor~entration.< at Water C:or~centratio~ 0,027 Yom fom %Jou Fees DiDnuufeaentttooeccxhhprrooosnnuiirccebbsiiocoeaanccaccruuimmouulsalatttiihooennmiionnsttthheemimmlooitnthhgeerSr caaennnddarssiuuobbissneetqqeuureemnnstt otrfraawnnasstffeeerrrttcooonbbcrreeenaatsrstatmmtiilioklkn,,s.tthheTeobbrreeenaasssuttr--ffeeedd protection of all infant exposure protection of all segments of the population, scenario is the most limiting segments of the population, the fina health-based value for PFOS is set at 0.027 scenario in terms of water concentrations. To ensure the final health-based value for PFOS is set at 0.027 pL.Iag/L. `CCaanncceerrHHeeaalltthh BBaasseedd VVaalluuee ((ccHHBBVV)) == NNoott AApppplliiccaabbllee (CCaanncceerr ccllaassssiiffiiccaattiioonn:: `SSllooppee ffaaccttoorr ((SSFF)):: `SSoouurrccee ooff ccaanncceerr ssllooppee ffaaccttoorr ((SSFF)):: 20166) SSuuggggeessttiivvee EEvviiddeenncceeooffCCaracrciinnooggeenniicc PPootteennttiiaall ((EEPPAA 2016b) NNoott AApppplliiccaabbllee NNoott AApppplliiccaabbllee PPRFOOSS-PPaaggee 55 ooff 1111 33775522..00000055 STATE 07634031 STATE 07534031 Volatile: No TTuummoorr ssiittee((ss)):: LLiivveerr aanndd tthhyyrrooiidd ttuummoorrss wweerree iiddeennttiiffiieedd iinn bbootthh ccoonnttrrooll aanndd exposed animals at levels that did not show a direct relationship to dose. S`Suummmmaarryyooff GGuuiiddaannccee VVaalluuee HHiissttoorryy:: A chronic nHBV of 1 IJg/L was first derived in 2002. A revised chronic nHBV of 0.3 IJg/L was derived in 22000077 aanndd pprroommuullggaatteedd aass aann nnHHRRLL iinn 22000099.. IInn 22001166,, EEPPAA rreelleeaasseedd aa HHeeaalltthh AAddvviissoorryyooff 00..0077 uIJgg//LL ffoorr PFOS. MDH conducted a re-evaluation and derived a revised nHBV (applicable to all durations) of 0.027 IJg/L in 2017. The 2017 nHBV is lower than the previous value as the result of: 1) incorporating the most recent toxicological information and 2) chemical-specific exposure concerns from breastmilk. to iio rs i Summary of toxicity testing for health effects identified in the Health Standards Statute (144.0751): Even if testing for a specific health effect was not conducted for this chemical, information about that effect might be available Ten[omumme [ovenron[vam] from studies conducted for other purposes. MDH has considered the following information in developing health protective guidance. Endocrine Immunotoxicity Development Reproductive Neurotoxicity Tested for sSpoeecificeetftfeecctt?s Yes Yes or ne Effects observed? Yes1 Yes2 Comments on extent of testing or effects: Yes Yes3 Yes Yes4 Yes Yes5 [Note: MDH conducted a focused re-evaluation which relied upon EPA's hazard assessment and key study identification (EPA 2016a). A complete evaluation of the toxicological literature was not conducted.] 1 NNuummeerroouuss hhuummaann eeppiiddeemmioiollooggiiccaall ssttuuddiieess hhaavvee eevvaalluuaatteedd tthhyyrrooiidd hhoorrmmoonnee lleevveellss aanndd//oorr tthhyyrrooiidd disease in association with serum PFOS. Results from these studies have provided limited support for an association. Stronger associations were found in populations at risk for iodine deficiency or positive aannttii-T-TPPOO aannttiibbooddiieess ((aa mmaarrkkeerr ffoorr aauuttooimimmmuunnee tthhyyrrooiidd ddiisseeaassee)).. `SSttuuddiieess iinn llaabboorraattoorryy aanniimmaallss hhaavvee rreeppoorrtteedd ddeeccrreeaasseedd sseerruumm tthhyyrrooiidd lleevveellss,, iinn ppaarrttiiccuullaarr,, tthhyyrrooxxiinn ((TT44)) in offspring and adult animals at exposure levels similar in magnitude to the critical effect. Decreased T4 has been identified as a co-critical effect and Thyroid has been identified as an Additivity Endpoint. 2 AA ffeeww huummaan eppiiddeemmiioollooggyy sttuuddiieess havee eevaalluuaatteedd assssoocciiaattiioonnss bettwweeeenn iimmmmuunnoossuupppprreessssiioonn measures and serum PFOS. However, no clear associations were reported between serum PFOS and rates of infectious disease. Studies in laboratory animals have shown that PFOS exposure alters several immunologic measures (e.g., suppression of SRBC response, and/or increased natural killer cell activity). Some of these effects occur at exposure levels similar to the POD. As a result the immune system has been identified as an Additivity Endpoint and a database uncertainty factor has been incorporated into the derivation of the RfD. PFOS- Page 6 of 11 33775522..00000066 STATE 07534032 a=3 nHHduummloaawnnereepbpiiirddteehmmwieiooilgloohggt,yy hsstotuuwddeiiveeessr,hhaatvvheeisssauusggsggoeceissattteeiddonaannhaaasssssnooocctiiabatteiioeonnn bbcoeenttswwieseteeennntpp.rreennaattaall PPFFOOSS sseerruumm lleevveellss and lower birth weight, however, this association has not been consistent. `SDSettucuddriieeeassscceoodnnpdduuucpcbtteeodddiiynnwlleaaibbgoohrraatttooarrpyypeaaannriimsmaatllossbhheaavaveemoiiddneegnntttiiffhiieeeddmossseevtveesrreaanllsissteeinnvsseiitteiivfvfeeecddteesvveaelnlodo,ppmmienenpntataratl,l feefofffreemccsttsst.he sbbDtaaeusscdiiirsseeooasffshtetahhdveeepRRueaeplffseeborroeerdnneypccoeewretDDeiogodshsceet haaaapnnnpddgeeaccsoorsrrirrnteeosmspabpoleonneaddrmiinenopggnrossgdeeutrrhcuuetmmimvcceooodnsnectcevseneentlntrorsaapitttmiiivoeoennnteoofffafecnccoodntnscccehaeranrnnnd..g, eAAinsllpiiimanmiirettte,nededfrognnrymuu.mmsbbteherer ooff esmmftefuetedtcaaitbebsos,ollihiisnasmcmvleu((deea.i.glgns.g.o, iggrnellcupurccoeooratsseseeeddllecepvvheuealplnss,,gdeeiliapspitiddhin,mmmeweteatarlaebeboorloelibipsssrmmeo)r)dvuffeocodlltliolvaowetwiinhdnigeggvheeeexxlrpopopoesmxsuuperorneestuddaruunerrdiinlnegcgvhedldaseen.vvgeeellsooppimnmeeentnn.et.rgAAdydddititiioonnaall effects, including increased pup death, were observed at higher exposure levels. "4 AA ssmmaalll nnuummbbeerr ooff hhuummaann eeppiiddeemmiioollooggyy ssttuuddiieess hhaavvee rreeppoorrtteedd aann aassssoocciiaattiioonn bbeettwweeeenn pprreeccoonncceeppttiioonn ssseeorrmuuemmePPFFvOOSSiaaonndfddaggseeesssotnctaaittaiicootnniaaoelnl sddiiababebeetttweeessenaannsdderppurreemggPnnaaFnnOccSyy--aiinnnddduucdceeedcdrhheyyappseeerrtdteefnnesrsitioointn.y., TThhhoewerereevehhraa,sscaaollnsscooebbreenesennhave been raised over the possibilty some evidence of associations been raised over the possibility that this between that this is due 10 reverse causation. serum PFOS and decreased is due to reverse causation. fertility, however, concerns have SSrtetuupdrdioiedeussciitnnivllaeabbooorrrgaaattonorrsyywaaenniigimmhatasll,ss dddeoocnnrooettasiinnedddiicceaapttieedttihhdaayttmaffeelrrttsiilpitteyyriisms aacossueertnn,ssiitaivvneed eeenvndidpdpoeoinninctte,, owwfiittdhhisddreeuccprtreieoaansseeosfs tiinhnemmaallee arbbebiloopovooreodd)d--.ttueecssTtttihveeeessr--eobbfraaogrrrarieinee,rsrtoowhcceeccuiRugrrIhrrDtiinsn,wggodaauettlceedrxexbpapeososespudurroreeeteplclieedtvviiedevlelyssmohfhaiitglghhsheepesrererttmhehafafncneocttuhthsnootss,eeanccadauuessivinnidggedndeceveveeolloof ppdmmiseernuntptaatlilottnooxxoiifcctitthyye((sseeee above). Therefore, the RfD would be protective of these effects. a5nDDiemeavvleesl.looppImmnecenrntetaaalsl enndaeumurorootttooorrxiicacciitttiyyviaatnnyddanaaddduuldlttecnnreeueurarosotetoodxxihciciaitbtyyitssuttauutddiiioeenssohhfaamvvaeelebbeeoeefnnfspccrooinnnddguuwccatteesddriiennpollarabtbeoodrraafttooolrrlyyowing gcagreneististmitcaaaattlilisooe.nfnfaaIenllcctaasrnen. ddaTsalheacedctstaamettiioeooftnnofaarellcateecsxxtippavoroitsesyuuearrnenecdaaottdmellpeecavvrseeelslassesssdeiidmmbiyihllaaatrrbhtteiotouDtatehhtvieeoencclrroioittpificmcmaeallnateelefafffleoeccfAfttdsiaaptnnriiddnvgihhtaawyvvaEeensdbbpreeeoeeipnnnotr.iitnencdcRlluefusdoduelelloddtwsaainssfgrccooom-sacsdtrtuiuutliddctiiaeselssheuaufsfvseiiencngtgysi.wweaTlatdhteeeedrrsemimnaeaczozffneeescitttesesststetassnrteffoorerrenseleucalaortrmnsniiponnraggsesaafefnnedddctbmmsyeaemttmhoheorirgDyyheeiinvrn eaadlnonoipismmmeaalellsesnvteeealxxsl .ppAoodssdeeidtdivddituuyrriiEnnnggdddpeeovivneetl.olpRomepsemunelttonsortfrroaamss adults have yielded inconsistent results or effects at higher dose levels. RReessoouurrcceess CCoonnssuulltteedd DDuurriinngg RReevviieeww:: [[sNNtouotdteey::iMMdeDDntHHifciccooanntdidouuncc(tteEeddPAaa 2ffo0oc1cu6u)ss.eeddArreec--oeemvvpaallluueaattteiiooennvawwlhhuiaiccthhiorrneelloiiefteddhuuepptooonnxiEEcPPoAl'Aosg'sihchaaalzzlaairtrdedraaastsusrseeesswssammseenrnotttaanndd kkeeyy conducted] study identification (EPA 2016a). A complete evaluation of the toxicological fiterature was not conducted.] AAPeSSrTfTlSSuWoWrMiMnOOate((d2200C11h55)e.)m.iAAcssasslooscci(iaaPttFiiCoosnn):ooffPSSettraafttleeuoaarnnoddocTTteearrnrrciititoocrryAycSSodollii(ddPWWFaOasAst)tee&MMPaaennraafggleoemrmoeeonnctttaOOfnffefiiccSiiaaullfss.o.nate (PFOS) Information Paper. Perfluorinated Chemicals Information Paper. (PFCs): Perfluorooctanoic Acid (PFOA) & Perfluorooctane Sulfonate (PFOS) AAPeTTrSSfDlDuRRo.r.oa((l22k00y11l55s)..)." ""ARgAeetrngiceyefvefoodnrrTATcouoxgxyiuiccstSSu1u5bb,sst2taa0nn1cc5,eessfraaonnmdd iDDtipis:see/aawsvsieew.RRaeeigigssdistrrt.ryy.c.iDDcrragafoftutlTToooxxxpiirccoooflliooeggisic/ca1al5l2PP0r0roo.fpfiildleef.ffoorr Perfluoroalkyls." Retrieved August 15, 2015, from http://www.atsdr.cdc.gov/toxprofiles/tp200.pdf. AAnuauststitrornaaallliiaagnnuHiHedeaaalnlttchhePPorrnoottheeucctmtiioaonnn PPhreriiannlcctiihppaarlleCfCeoormmemnimctetitetveeae.l.ueeensntHfioeeraalpltethr..-((a220n011d66)p).o.l""ye-efnnlHeuoearaioltathlhkySSlttaasttueebmmseetnantnt:ceIInnstteferorirmimuse in snisiiatteteitonnnvvaeevslstgtiiuggiahadtetaiiaonolnntcsshe iinonnsnwAA.uhusgustomrtravaallianiaau..he""neffvarroiltomrhmornemfeenretnfcaecivsahlueeetss/foDropceurm-eanntdsppfoalys--filunofreoraml:khyelaslutbh-svtaanlcueess:faohroupssepdifn. http://www.hea~th.nsw.q~v.au/envir~nment/factsheets/D~cuments/pfas-interim-hea~th-va~ues-ahppc.pdf. CBBhiijaalannngdd,,, DSS.J.,, EPPhCCvNNesRRmeaennns,seeJnn,L, BEEuJJtePPneihetotfeefrr,mmaaHnnI,, GAACCPEErinMMcaaesnss,s,,(2JJ0WW11)vv.aann"PddeeerrrfuHHoooroooarn,l,kyMMiJJSuvviaafnnonEEarrtkke,,sKKCWWavuvasanen ADDkiijykk,l, SSCC Chain Length-Dependent Chang, DJ Ehresman, JL Chain Length-Dependent Hepatic Steatosis and Hypolipidemia Mainly by Impairing Lipoprotein Butenhoff, HMG Princen, (2011). "Perfluoroalkyl Sulfonates Cause Alkyl Hepatic Steatosis and Hypolipidemia Mainly by Impairing Lipoprotein PPrroodduuccttiioonn iinn AAPPOOEE"3*3--LLeeiiddeenn CCEETTPP MMiiccee.."" TTooxxiiccoolloogqiiccaallSScciieenncceess 112233((11)):: 229900--330033.. PPRFOOSS--PPaaggee 770o1f1111 33775522..00000077 STSTAATTEE0705753344003333 sBButututedenynhhwoioftfffh,, pJJo.,,tSSasCCsiCCuhhmaannpgeg,r,fGGiuWWoroOOolIcssteeannn,,ePPsJJulTTfhhoonomamftoeforidrnd,,Sp((22r00a11g22)u.)e. ""DCCahhwrrlooennyiiccraddtiisee.tt"aaTrryyoxttioocxxioiccliiottygyyaa2nn9dd3:ccaa1rr-cc1ii5nn.ooggeenniciciittyy study with potassium perfluorooctane sulfonate in Sprague Dawley rats." Toxicoloqy 293: 1-15. JCCa-arPriiAoonuut,,iRRg.,n.,acBB, VVBeeyyLrreaannBdid,z,ecAA. YY(aa2m0m1a5ad)d.aa,,"PAAerBBfelerurroreerbobia,i,lkDDylZZaaacklikodo,,(SSPFDDAuuArr)aannlded,v,eClCs PPaoonlldlloopnnrooo,,fiPPleMMsaiarnrccbhhraaenandsdt,, mJJi--lCCk,LLeebbllaanncc,, maternal and J-P Antignac, maternal and chord serum of French women and their newborns." Environment International 84: B Le Bizec, (2015). "Perfluoroalkyl acid (PFAA) levels and profiles in breast milk, chord serum of French women and their newborns." Environment International 84: 7711.-6811.. CCODCC ((22001166).). CCeenntteerrss ffoorr DDiisseeaassee CCoonnttrrooll aanndd PPrreevveenntitioonn.. BBrreeaassttifeeeeddiinngg RReeppoorrtt CCaarrdd.. CCExODpCCos((u22r001e177)t.)o. ECCnevenintrteeorrnssmeffonortraDDliissCeehaeamssieecCCaolonsnt.trrooUllpaadnnaddtePPdrreeTvavebenlntetiisoo,nnJ((aCCnDDuCaC)r.)y. 2FFo0ou1ur7rt,thhVNNoaalttuiioomnneaalOl nRRee:eppoorrtt oonn HHuummaann Exposure to Environmental Chemicals. Updated Tables, January 2017, Volume One. CC(2hh0a1an6n)gg.,, "SS..,E, BBvCCaAAlllllueennoa,,ftsKKeLiLrAAounnmnddrrelesisp,,idDDtJJhyEErothivrdee,ssmamnaandn,,heRRpaFFtaaillcvvooc,,inAAicPPalrroocvvheeennmccihhseterrr,i, eGGsWWin aOOslIsssoeecnni,,aJJtiLLonBBuuwtiteetnnhhhosofefffr,,um T(pp2oeex0rri1ficl6uuoo)ol.roroo"gEoioccvctaataallunnSeaecstsiiuouelnlnffocoonenfsaastteee(rSu((uPmPbFFmOilOiptSSti)de),diintnmhacycnryyounnisodocm,mroaiolnplggtduusshemmpoaontnikckeecyylissniaacfafttleercr hooreraamll iddsotorssieiinnsgginwwiaittshhsppooocttiaaatssiossiniuumwmitPPhFFsOOeSSr.u."m" Toxicoloqical Sciences (Submitted manuscript). iCCnhhdeeunnc,,esTT,.o, xLLidZZahhtaiavnnegg,s,tJJr--eqqssYYuauene,,d2Za--pqqopLLtyvo,,sWWisXXiiinaa,t,hYYe4-lj uW Wnaganno,,f YYra--tyyoLLfiif,, sSSp--rqqinXXguu.*, R((e22p00r112o2)d)..uc`"tPPirrveeennaaTttoaaxlliPPcoFFlOOoSSgyee3xx3:ppoo5ss3uu8rr-ee 545.induces 545. oxidative stress and apoptosis in the lung of rat off-spring." Reproductive Toxicoloqly 33: 538- EDDvaaannliiussahhtiMMoininnioissfttrrhyyeaoolffttthhheheaEEznanvrvidirrsoonanmnmedennpttro((2p200o11s5a5)l). oPPfeearrffhllueuaoolrrtoohaallbkkayylslaaettdeeddqussauulbibstsyttaaCnnrciceteessr:i: oPnPFFfoOOrAAd,,riPPnkFFiOOngSSwaaatnneddr,PPFFsOoOSlSAaA.n. d `ground water. Environmental Evaluation of health hazards ground water. Environmental project No. 1665, and proposal of a project No. 1665, 2015. health 2015. based quality criterion for drinking water, soil and pDDeoornnfggl,u, oGGr.c.--oHHc.,t,aYYne--HsHuiZZfhhoaannnagtg,e, eLLxZZphhoeesnnuggr,,eWWonLLiiiuum,,muYYn--HoHtJoJiixnn,i,cQQt-y-CCinHHeae,d,ul((t2200m00a99)l.)e. ""CCC5hh7rrBooLnniIiccS eemfifcffeee.cc"ttssAotofcf hives of Toxicology 83: 805-815. perfluorooctanesulfonate Toxicoloq 83: 805-815. exposure on immunotoxicity in adult male C57BL/5 mice." Archives of pDDeoornnfggl,,uoGGr..c,,oMMctMManeLLsiiuuu,,ifDDonW Waataneng(g,P, FLLOZZShh)eenongng,,tZhZeFFbLLaiilaaannngg,c,eYYoHHf tJJiyinnp,,e((221002111n1)d.).t""ySSpueubb2--ccchhyrrtooonnkiiiccneeeffiffneeccatdtuoolfft CS7BL6 mice" Archivesof Toxicology 86. 1235-1244. perfiuorooctanesulfonate (PFOS) on the Archives of Toxicology 85: 1235-1244. balance of type 1 and type 2 cytokine in adult C57BL6 mice." aEEcFFiSSdAA(P((F220O00A088)).).anEEduurrtoohppeieeraasnnaltFFsoo.ooSddciSSeanaftfeiefttiyycAAOuupthtihonroiirotitnyyo..fPPeterhrfeflluPuoaornrooeoolccottanannCeeossnuutllaffomoninanatateent((sPPFFiOnOStS)h),e, Fppeoerorffdlluuoccrhrooaoiocncttaannooicic. (Question No EFSA-Q-2004-163). acid (PFOA) and their salts. Scientific (Question No EFSA-Q-2004-163). Opinion of the Panel on Contaminants in the Food chain. sEEugglefeoggnhhaytye:PPPPAaacnnoddmpMMarLLioosrrobbneerrof((22e00s11t11)i.)m.at""AeAdnn iaansstssaeekesssswmmiteehnntvtaoolffuttehhseeieenfxxepproorsseudurrfeerooofmf AANmmHeeArriNiccEaaSnnssdattootapp.e"errJffloluuuorornroaooloccottafannee Exposure sulfonate: Exposure Science and Environmental A comparison of estimated Science and Environmental Epidemiology. 21: intake with values Epidemioloqy. 21: 150-168. inferred from 150-168. NHANES data." Journal of `FFCrrhiiisas-n-HHgaaennsssieennnB,,oBdB..y((1C19o98m61p1)o.)s.iBBtoiooddnyy.W WaPaetdteeirartCCrioocmmsp,pa2ar8rt(tm2m)ee,nnt1ts6s9ii-nn1CC8h1hililddrreenn:: CChhaannggeess DDuurriinngg GGrroowwithh aanndd RReellaatteedd Changes in Body Composition. Pediatrics, 28(2), 169-181. `FFGrreoonmmzmemele-,,BoHHr..o,CvCiczMMeoonsysc,chh,B, MMKolMMeotorzrokovovi,ittzWz, |IVAAolllobkaea-l-A,All(ee2jj0aa1nn0d)dr.ree,",PSSreBB-ooaeenhhdmmePreo,rs,tMMnatKKaiilrraaEnnoxogglpuluo,,sFFeFFtaaobbePere,rr,f|IluHHoaarnninnniabibtaaeldl,, OO Compounds (PFC) * GenzeI-Boroviczeny, Compounds (PFCs)." Emironmental Science & Technology 44: 7123-7129. B Koletzko, W Volkel, (2010). "Pre- and Postnatal Exposure Environmental Science & Technology 44: 7123-7129. to Perfluorinated GGHoeecrrhmmsaaaunnerMMlianinniisdstktrrryyeioosff.HHeSeatalalttthhem((22e00n00t66)b.).yAAtshsseseeDssrssimmnkeeinnntgt ooWffatPPeFFrOOcAAoiminnmttihhseesiddofriinnnkk(iiTnnrggiwnwakatwteaersrsooeffrttkhhoeemmGGieesrsrmmioaannn) of the Hochsauerlandkreis. Statement by the Drinking Water commission (Trinkwasserkommission) of the P PFOSF--PPaagOgee 88oSoff1111 33775522..00000088 STSTAATTEE 0077553344003344 `GPGreoervrmimsaainnonMMailirnEiivssattrlyyuaootffiHHoeneoaalfltthhPFaattTtthihnee DFFreeiddnekeriranalgl WEEanntvvieirrroonwnmimteehnntttAhAeggeGeunniccdyyeJJSuuunnbeest22a11,n,c22e00s00BP6ie/rrreefvvliiossreeoddacJJtuulalyyno11i33,c, a22c00i00d66.. (PFOA) and Perfluorooctane Sulfonate (PFOS) as Examples. Provisional Evaluation of PFT in Drinking Water with the Guide (PFOA) and Perfluorooctane Sulfonate (PFOS) as Examples. Substances Perfluorooctanoic acid HHeeaalltthh CCaannaaddaa ((22001100).). DDrriinnkkiinngg WWaatteerr GGuuiiddaannccee VVaalluuee PPeerrfflluuoorrooooccttaannee ssuullffoonnaattee ((PPFFOOSS)).. SHHueeabalslttthhanCCcaaennsaadd(aaP.F.A((S22)00.11"66aa).)R.et""HrHieeeaavlletthdh CMCaaannyaad2da7a,''ss20DD1rr6iin,nkkfiinnoggmW Waatteerr SSccrreeeenniinngg VVaalluueess ffoorr PPeerrffluuoorrooaallkkyyllaatteedd Shiutbps:/tasn3cdeoscu(PmFeAnStl).o"udRoergtr/iedvoecdumMeanyts272,725061366,6frHoemalth-Canada- PEASScreening-ValuFeasct.: Sheet pdt. http://s3.documentcloud.orq/documents/2756386/Health-Canada- PFAS-Screening-Values- Fact- Sheet.pdf. `HHCeeoaanlslttuhhlaCCfaainonanaddDaao..cu((2m200e11n66t)b".),. *"fPPreeormrfflhuuicotrrooo/oohccettaaanlnteehSSyueuialffnooanndaaittaeens((PPaFFcOOcSSa))lhiinneaDDlrrtiin-nkksiiynnsggteWWma.atsetery.rs.trDemaraet:ft ffoorr PPuubblliicc saCnotneslcuolantsiounltaDtoicounms epnert.f"l, uforormoochttatnpe:/:/shuefaolnthaytcealndaodcuiamnesn.tq-ce.cnag/.hpehapl.th-system-systeme- sante/consultations/perfluorooctane-sulfonate/document-encj.php. "KKEaaxrrprmmoasanun,r,eAoA..f, P|I eEErrrfiiccussooornni,,naBBtevvdaannChBBeaamvvieelcl,a, lPPsOOrDDoaaurrngneehrruuLdda,c,tMMatiAAounu:nneeL,,eAvAeGlGslloyyfnnnM, aSStcLLhiiggenndeellHl,,uGGmaLLniinndMdisslttrkrooammn,,d((2S200e00r77u))m. and a Temporal Trend, 1996-2004, in Sweden." Environmental Health Perspectives 115: 226-230 "Exposure of Perfluorinated Chemicals through Lactation: Levels of Matched Human Milk and Serum and a Temporal Trend, 1996-2004, in Sweden." Environmental Health Perspectives 115: 226-230. YKKiSimm,,ShS$i-n.K-,.K,J.,HKKLTTeeLL,eeee(,,20CC11SS).KKaa"nnDgig,s,tLLioTTuaatoio,o,nKoKfKKpaaennrnnfaalnnu,,roKKcRRheKKmiiimmc,,aClCsKKbKKeiitmmw,eJJeSnS sLLeeeere,a, aPPnSSdPPmaairrklk,k, fYYrWWomYYt0oh0eo,,sJJaYYmeHHaa,, mothers and YS Shin, JH mothers and impications Lee, (2011). implications for prenatal and postnatal exposures." Environmental "Distribution of perfluorochemicals between sera and for prenatal and postnatal exposures." Environmental Pollution milk from Pollution t11h559e9::sa116m699e--117744,. (LL2aa0uu0,,3)CC...,,"JJERRxpTTohhsiiubbrooeddeteoaaupuxe,r, fRRluGGorHHoaoancnstsaoonnne,, sJJuMMlfoRRnooaggteeerrsds,,iBBnEEg GGprrreeeyyg,,nMManEEcySStitaannnfttaootnna,,nJJdLLmBBouuuttseeenn.hhooIff:f,,pLoLsAAtnSSattteeavvleennssoonn,, v(2a0lu0a3t).io"nE.x"pToosxuirceoltoogipcearlfluSocrioeonccteasne74:su3lf8o2n-a3te92during pregnancy in rat and mouse. I1: postnatal evaluation." Toxicological Sciences 74: 382-392. `LLieiuux,,poJJs..,uJrJeLLoi,,f YYpeLLriiluu,u, oHHriMMnaCCthehadannc,,oYYmpZZohhuaaono,d, sZZfCCoarai,in, eYYwbWWourun,,s((.22"0011E11n)v.)i. r""oCCnoommmepnpatarIriinsstooenrnnaootnnioggneeasslttaa3t7t:iioonn12aa0nn6dd-1ll2aa1cc2tta.attiioonn exposure of perfluorinated compounds for newborns." Environment International 37: 1206-1212. rLLeoocppeeepzzt--oDDrosvoavclaa,lnS, .Sb,.e, RRmoSdSiaaflliggeaadddoob,,yAApeLLraafffluuueeonnrttoeeo,,ct((2a2n001e166)s.)u.lf""ToTnhhaeeteeexx(ppPrrFeeOssSss)iiooninnooaffdussleetvveemrraaalllerreeatppsrr.o"odduuCccthtiievvmeeohhsooprrhmmeoornneee155: 4re88c.e4p9t7o.rs can be modified by perfluorooctane sulfonate (PFOS) in adult male rats." Chemosphere 155: 488-497. LrLeuupeertbokkdeeurrc,,tiDD.o.,n, MManTTdCCcaarsosese,s,-RfRoGGstYeYroortrkku,, dJJeAAsMMooooforpreee,r, lKKuJJorHHoaoancnstseaennne,,sJJuLlLfBBounutateetnenhh(ooPfffF,,O((S22)0000i55nbb)r.)a.ts""TT"wwTooo-x-gigecenoneleroragatyti2ioo1nn5: 126- 148.reproduction 148. and cross-foster studies of perfluorooctanesulfonate (PFOS) in rats." Toxicolocjy 215: 126- `LLeuuxeepbbokkseeurrr,,e DD1.0.,, pRReGGrflYYuooorrrkko,,ocKKtJJanHHsaasnnuslsefenon,n,aJJteAA (MMPooFooOrrSee,), JJiLnLSBBpuurttaeengnhuhaeof-fffD,,a((w22i000e05y52a)ra.)t.s:""NNdeoeosonena-atrtaaellspmmooorntrsataeliliattyyndffrrobomimociinhneuumttieecrraool and pharmacokinetic parameters." Toslcology exposure to perfluorooctanesulfonate (PFOS) and pharmacokinetic parameters." Toxicolocjy 215: 149-169. in Sprague-Dawley 215: 149-169. rats:dose-response and biochemical "LLvGv.,lu2Zc.,oGsGe Lia,i,ndYY LLLiii,p,iCGd YHYioinnmgge,,oJsJtCCahhseeinns,,iTTn ACCdhhuelentn,,RaJJtW WeIeisi,,iYmpLLaiiinn,r,eYd bJJiiyaannEgga,r, yYY-LW WiafaennggE.x, p8BosSSuhhru,e, tBBoXXPuue,r,fSiuXXouru,o,oc((2t20a0n11e33.)). `Sulfonate * Environmental Toxicology 26: "Glucose and Lipid Homeostasis in Adult Sulfonate." Environmental Toxicolocjy 28: 532-542. Rat Is Impaired 532-542. by Early-Life Exposure to Perfluorooctane tMMheDDMHHat((22e00r0088o)f.).PMMrioinnpnnoeessseoodttaaRuDDleeesppaaRrretmltametnientnogotfftoHHeHeaelaatltlhh.t.hSSRttiaastketmeLimenneittnosotofffNNGeereeoddunaadnnwddatRReerea.assNoonTnaPabbl(l2ee0nn1ee6s4s)ss.((SNSOaOtNNioAAnRRa)l) iinn TtTPhoeoevrxiliMccuoooaccrttoooelolroocgogiyyfanPPPcrrirooocpggoArraascmmed.d. (RDDPrurFaaleOfttsASS)RyysoestltaeePtmmienaragtftilitccuooRRrHeoeevovaicieltethwawnRoeoffisSIIkumnfmLmouimnnuaonitttsoeotroo(ifxPciGcFiitOrtoyySu)AAn.ssdsswoocacitieaartt.eeNddTwwPiitth(h20EEX1xp6poaos)s.uurNreeatttiooonal Perfluorooctanoic Acid (PFOA) or Perfluorooctane Sulfonate (PFOS). PPFFOOSS--PPaaggee 990o1f 1111 33775522..00000099 STSATTAETE0705753344003355 MMInDDcoHHrp((oMVriainntnneeeHssouottmaaaDDneeEppqaaurrittvmmaelenentnttooffDoHHeseaelatltChh)a).l.c((u22l00a1t17i72oa)n.)s. "i"MnMfoDDHHDeHHreieavalaltththiRoRoifinsskkOrAAasslsseeRsesfssemmreeennnttceMMeeDttohhsooeddsss(ttoMoay 2011, rInecvoisrpedor2a0te17H)u.mfaonmEiqutivaolen:t DhoesaelCastlcautleatmionnuss/idnitovsD/eehri/viastkio/nquoifdOanrcael hReedrfeerfeqnuciede.Dopsoe.s (May 2011, revised 2017)." from http://www, health, state, mn. us/divs/eh/risk/cjuidance/hedrefquide, pdf. MMPFODOHHS((22a00n11d770Pb).)F.O((MAMiiannnnneedssIoottstaaUDDseeeppianarrttmhtemeDneetonnotfvfaHHteieaoalnltthho))f BBHauaccmkkaggnrrooHuuennaddltDDhoo-ccbuuammseeednntWt:aTTtooexxriiccGooukkiiidnneaetntiiccceMMVooadldeuelelsff.oorr PFOS and PFOA and Its Use in the Derivation of Human Health-based Water Guidance Values. pNNreeoljlsseoocnnt,,dJJa..t(a(220b01a16s6).e).d""oPPneerrJssuoonnneaall9,CCo2om0mm1mu5nuiMnceieactatitiinoognn ArregegegaanrrdddaiinnaggnMMdDDMHHateMMrNNia((sEEfaaossrtttMMheeettArrdoov))iPPsoFFrCCy bbPiiaoonmmeolonnittiotootrrhiinengg hpEEinrnovtvjieiwrrcootnnidmmaeetnanthtaeablalalstHHeheedasaltlottahnhteTTJrumraannccekkuii9snn,/ggd2iaa0vsnn1/dd5pedBBMriiaeoocemkmitioonngnng/iiptoaArnrigsinnleggndPParrooaggn2rrda0amm1M.5.uanteermiaalsteforrithaesAodtv.i"sory Panel to the http://www.hea~th.state.mn.us/divs/hpcd/trackincj/pane~/2~15Junemateria~s.pdf.'' ENNxTTpPPos((SuSreeeppttteoemmPbbeererfrl22u00o1r16o6)o.)c. tNNaanatotiiioocnnAaaclliTTdooxoxiriccPooeccrooillouogogryyoPPorcrootggarrnaeammSuMMlofoonnnooagtgrer.aapphh -- II mmmmunuontootxoixciciittyy AAssssoocciiaatteedd wwiitthh Exposure to Perfluorooctanoic Acid or Perfluorooctane Sulfonate. QQIsiiuua,, PLLo.t,XeXntZiZahhlaanTngag,r,gXXetZZfhhoaarnnPgge,,rfYYluZZohhraaonnoggc,t, aJJneGGuuS,u, lMMfoCCnhaheteenn-,,InZZdZuZchhaeandngg,R,epXXrWoWaduancngtg,i,vSSe--LLD.,ysW Wfauannngcg,t,io((2n200i11n33)M.).al""SSeeerMrtitooclelii.CC"eellll TIsosaicPoolotegnictiaall TScairgenect efosr1P35e(r1f)lu:or2o2o9-c2ta4n0.e Sulfonate-lnduced Reproductive Dysfunction in Male Mice." Toxicoloclical Sciences 135(1): 229-240. PRRFIIVOVMSM... NNAaatptiirooonnpaaollsIIannlsstftiiotturuttweeaftfooerrrPPquuubabllliiicctyHHseetaaallntthhdaaarnnddds tithnheeacEEcnnovvriidrroaonnnmcmeeennwtitt((h2200t11h0e0).)W.aEEtnnevvriirrFoornnammmeeenntwtaoalrl krriissDkkirlmeimcittiitvsse.ffoorr Report PFOS. Report 6017141312010. A proposal for water 601714013/2010. quality standards in accordance with the Water Framework Directive. SScchheerr,, DD.. PPeerrssoonnaall CCoommmumnuincaictaitoionn.. ((22001166).). PPFFCCss iinn FFDOLL SSttuuddyy.. `SStSeueadacicaeast,, oAAn..,pPPeJrJfTTlhuhooormmofoofocrtrdda,,neKKsJJulHHfaoannnassteeenn,p,oGGtaWWssOOilulssmeenns,a,lMMt TiTn CCcayasnseoe,m, oJJlLLgBBuusuttemenonhnhokoleffyf,s,.(("220T00o02x2)i)..co""SlSouugbbiccchharolonnSiicccitteoonxxciicecisltyy 68: 249.254. studies on perfluorooctanesulfonate 68: 249-264. potassium salt in cynomolgus monkeys." Toxicoloclical Sciences `*SSSeeuaabcc-aact,h,rAAo..n,iPPcJJdiTTehhtoaomrmyfoftororxddi,c,iKtKyJoJ fHHaapnnostseeansn,s, iLLuAAm CCpleleermmfleeunno,,roSSoRRctaEEnlldedrsriiuddlggfeeo,,naCCtRRe nEEllrccaootmsm.ob"eeT,,oJJcLLolBBuoutgteeynnhh1oo8f3ff:,, ((122100700-313)3).1.. "Sub-chronic dietary toxicity of potassium perfluorooctanesulfonate in rats." Toxicolocjy 183:117-131. TTPrCCoEEtQeQ.ct. i((v22e001C16o6)n.).ce""nTTteerxxaaatssioCCnooLmmeivmseilsssisio(oCnnLoso)nn.EEnnvvfiirrrooonmnmmeennttaall QQuuaaltliyty.. TTeexxaass RRiisskk RReedduuccttiioonn PPrrooggrraamm ((TTRRRRPP))-tPrpostec/twivwewCconecdentetxraasti.ognoLvierveemlsed(PiaCiLosn)p.", pfromp. hr, https://www.tceq.texas.gov/remediation/trrp/trrppcls.html. T`TShhtiiebbvooeddneseaoaunux,x,,C JJ.,L,aRRu,GG(2HH0aa0n3ns)s.oonn",,EJJxMpMosRRuoorggeeetrrsos,,pBBerEElGGurorereyoy,o, cBBtDDanBBeaasrrubbleefeeo,,naJJtHHe dRRuiirccihhnaagrrddpssr,,eJJgLLnaBBnuucttyeennihnhoofafftf,, aLLnAAd mouse. I maternal and prnatal evaluations." Stevenson, C Lau, (2003). "Exposure I: maternal and prenatal evaluations." Toxicological Sciences 74: 369-381 to perfluorooctane sulfonate during pregnancy Toxicoloc~ical Sciences 74: 369-381. in rat and mouse. TTPhehorofmmlfuofoorrrddo,,ocPPt..a(n(22e000S02u2)l.)f.on11i00c44A--WcWieedeePkkoDDtiaieesttsaairryuymCChShrarlootnni(iccPFTToOoxSxi;icciiTtty-y6aa2nn9dd5)CCanarrccRiainntoosg.geenFniicinciaitltyyRSSetptuourddtyy.wwViitothhlumes IX. Covance Study Perfluorooctane Covance Study No. 6320-183. Sulfonic Acid No. 6329-183. Potassium Salt (PFOS; T-6295) in Rats. Final Report. Volumes I-IX. URUnenigituteelddatKKiioinnnggsdd2oom0m.0.0/DD0rr1iinnkskpiinencggifWWiacattteeorrPIIFnnssOppSeecc(ttpooerrraaftteleu((o22r00o0o07c7)t.)a. nGGsuusiiuddlaapnnhccoeenaootnne)tthhaeendWWaPatFteeOrrASSuu(ppppeplrlyyfl((uWWoaraottoeecrrtQQaunuoaaiicltityay)c)id) concentrations in drinking water. Regulations 2000/01 specific to PFOS concentrations in drinking water. (perfluorooctane sulphonate) and PFOA (perfluorooctanoic acid) AUUmSSbiEEePPnAAt W((22a00t00e00)r.).QuUUaSSlitEEynnvCvirirriotoennrmmieaenfntotarallthPPerrooPttreeoccttteiiocotnnioAAnggeoefnnccHyyum((EEaPPnAA)H.).eaOOlftffhfii.cceeEoPofAf -WW8ata2e2ter-.r8.-MM0e0et-th0ho0o4dd.oollooOggcytyoffbooerrrDDe2er0ri0ivv0ii.nngg Ambient Water Quality Criteria for the Protection of Human Health. EPA-822-B-00-004. October 2000. PFPFOOSS -PPaaggee 11000off 1111 33775522..00001100 STSATTAETE 0077553344003386 RUUeSSseEEaPPrAAch((22a00n111d1).)D.eUvUeSSloEEpnmnvevniitrro.o"nnmmeefnrntotaamll hPPirrioopttsee:cc/ttciiofononuAAbg.geeepnnaccgyyo""vEEixnxcppeooassluurrrieeskFF/aarccettcooorrrssdiHHsaapnnlddabyb.oocooikkm.?dOOfsffifiidcc=ee23oo6ff252. Research and Development." from https://cfpub.epa.gov/ncea/risk/recordisplay.cfm?deid=236252. DUUSSocEEPuPAAm..e((n22f0o0t1r1660P)ce.)r.f""lUuUoSSroEEonncvvtiiarrnooennmmSeuelnnfttoaanllatPPreroo(ttPeecFctOtiiSoo)nn.A"AggeeRnnecctyryi--evOOefffdfiicMceeaoyoff 1WW9a,taet2er0r.1.6HH,eeafalrlttohhm EEffffeeccttss SSuuppppoorrtt hDiotcpsu:m/iewnwtwf.oerpaP,egrfoluvsoirotoesc/tapnreodSucutlfioonnaftlee(sP/F20O1S6-).0"5/dRoecturimeevnetdsiMhaesyd1_9p,fo2s01f6i,nafr-opmlain.odt, https://www.epa.gov/sites/production/files/2016-05/documents/hesd pros final-plain.pdf. AUUdSSviEEsPPoArA.y. f((o22r001P16e64rd)f.)l.u""oUUrSoSocEEtnnavvniierrooSnnummlefenontntaaaltlePP(rrooPttFeeOcctStii)oon"n AAgRgeeetnnrcciyyev--eOOdffMffiiacceye oo1ff5,W Wa2at0et1er6r.., DDfrrriionnmkkiinngg WWaatteerr HHeeaalltthh Ahhitdttpvpssis:ow/!rwwywwfow.r.eePppeaa,r.f,lgquooovvrio/ssoiitcteteass/n/peprorSodduuulcfcottinoianot/nefiflel(Pess/F2/O0210S16)6.-"O-055R//ddeootcrciueummveeendnttsMsi/aopyffoo1ss9,hh2eea0al1ltt6hh, faardodvmviissoorryy ffiinnaall--ppllaaiinn.ppddff.. WSWiapamembs,baauMugghMha,,rtJJi..n,,,RRKWWDSSaeset,tzzeJerCr,, DAAeMMWitPPtiit,trruuMzzzzSeetllirlooy,n, aJJr,LLiiRuv,,JDDudMMsoRRneei,fif,,KANNCCHoKKuilceekiin,nsstCtrreeLuuaeeurr,,, (NN20CC1h3h)ii.nngg,",DYYosW Wiamaenntgrg,i,cNN T`Saaoninxpcciehhcsooo,rlriioMnngggiMcooaafflriitnSinnc,vviiiKevvnooDcaaeannssdd, 1Jii3nn6C:vviDitt3rre0ooW 8-ssi3tttu2tu,7dd.MiieessSfftoroyrrnppaeerr,rfflRluuoJoruroodoosccottanan,nooKaaAtteeHaaonnuddckpp,eerCrfflluLuoaourro,ooo(cc2tt0aa1nn3ee)ss.uul"lDffooonnsaaitmtee.e.""tric Toxicoloqical Sciences 136: 308-327. WWmaeatnnaggb,,olLL.i.,,sYYm WdWiasantngug,r,baYncLLeiiaasnniggn,, BJJAULL,iB, /YYCLLmiiuui,,cJJe ZZthhharanonuggg,,hAAinZZhhihbaainntgigo,,noJJfFFulu,o, wGGdJJeiniaasnniggt,y, ((l22i00p1o14p4)r).o.t"e"PiPnFFsOOeSSxcriinentddiuuocnce.e"dd lliippiidd `SmScceiieteanntbtioiffiilcicsmRReepdpoiosrrttutssrb44;a: n44c55e88s22..in BALB/c mice through inhibition of low density lipoproteins excretion." 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